Lansoprazole Drug Study

Lansoprazole
Brand Name: Prevacid
Pregnancy Category B
Drug classes: Antisecretory agent, Proton pump inhibitor

Therapeutic actions
Gastric acid-pump inhibitor: suppresses gastric acid secretion by specific
inhibition of the hydrogen/potassium ATPase enzyme system at the secretory
surface of the gastric parietal cells; blocks the final step of acid production.

Indications
Short-term treatment of active duodenal ulcer (<>
Short-term treatment of gastroesophageal reflux disease: severe erosive
esophagitis; poorly responsive symptomatic gastroesophageal reflux disease
(<>
Treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison
syndrome, multiple adenomas, systemic mastocytosis)--long-term therapy
Maintenance therapy for healing of erosive esophagitis, duodenal ulcers
Eradication of Helicobacter pylori infection in patients with active or
recurrent duodenal ulcers in combination with clarithromycin and amoxicillin
Short-term treatment of symptomatic gastroesophageal reflux disease and
erosive esophagitis in children 111 yr

Contraindications
Contraindicated with hypersensitivity to lansoprazole or any of its
components.

Adverse effects
Headache, dizziness, asthenia, vertigo, insomnia, anxiety, paresthesias,
dream abnormalities, Rash, inflammation, urticaria, pruritus, alopecia, dry
skin, acne,
Diarrhea, abdominal pain, nausea, vomiting, constipation, dry mouth, URI
symptoms, cough, epistaxis, Gastric cancer in preclinical studies, back pain,
fever

Drug Interactions:
Decreased serum levels if taken concurrently with sucralfate
Decreased serum levels of ketoconazole, theophylline when taken with
lansoprazole

Nursing considerations
Administer before meals. Caution patient to swallow capsules whole, not to
open, chew, or crush. If patient has difficulty swallowing, open capsule and
sprinkle granules on apple sauce, Ensure, yogurt, cottage cheese, or strained
pears; for NG tube, mix granules from capsule with 40 mL apple juice and
inject through tube, flush tube with additional apple juice; or granules for oral
suspension can be added to 30 mL water, stir well, and have patient drink
immediately.
Arrange for further evaluation of patient after 4 wk of therapy for acute
gastroreflux disorders if symptomatic improvement does not rule out gastric
cancer, which did occur in preclinical studies.