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About the
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determine the sequences of the 3 billion chemical base pairs that make up
human DNA,
address the ethical, legal, and social issues (ELSI) that may arise from the
project.
What is it?
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To help achieve these goals, researchers also studied the genetic makeup of
several nonhuman organisms. These include the common human gut
bacterium Escherichia coli, the fruit fly, and the laboratory mouse.
A unique aspect of the U.S. Human Genome Project is that it was the first large
scientific undertaking to address potential ELSI implications arising from project
Ethical, Legal, data.
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Another important feature of the project was the federal government's longstanding dedication to the transfer of technology to the private sector. By
licensing technologies to private companies and awarding grants for innovative
research, the project catalyzed the multibillion-dollar U.S. biotechnology industry
and fostered the development of new medical applications.
Landmark papers detailing sequence and analysis of the human genome were
published in February 2001 and April 2003 issues of Nature and Science. See
an index of these papers and learn more about the insights gained from them.
For more background information on the U.S. Human Genome Project, see the
following
Videos
Chromosome
Poster
Presentations
Genetics 101
Gentica
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Espaol
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A genome is all the DNA in an organism, including its genes. Genes carry
information for making all the proteins required by all organisms. These
proteins determine, among other things, how the organism looks, how
well its body metabolizes food or fights infection, and sometimes even
how it behaves.
The particular order of As, Ts, Cs, and Gs is extremely important. The
order underlies all of life's diversity, even dictating whether an organism is
human or another species such as yeast, rice, or fruit fly, all of which have
their own genomes and are themselves the focus of genome projects.
Because all organisms are related through similarities in DNA sequences,
insights gained from nonhuman genomes often lead to new knowledge
about human biology.
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What are some of the ethical, legal, and social challenges presented
by genetic information, and what is being done to address these
issues?
The Department of Energy and the National Institutes of Health Genome
Programs set aside 3% to 5% of their respective annual HGP budgets for the
study of the project's ethical, legal, and social issues (ELSI). Nearly $1 million
was spent on HGP ELSI research.
For an in-depth look at the ELSI surrounding the project, see our suite of ELSI
pages.
Where can I learn more about the U.S. Human Genome Project?
Explore the links in the left-hand column including
Publications
Glossary