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A 65-year-old woman presented herself at the hospital with symptoms such as loss of
appetite, cramps, constipation, stains of blood in the stool, and change in the bowel habits. This
necessitated further diagnosis to determine the particulate cause of the patients condition
although the first disease that rang the mind of a medical practitioner was colon cancer.
Colon cancer affects the large intestine, lower parts of the digestive system and at times it
may advance to the rectum to cause what is referred to as colorectal cancer ("Overview - Colon
Cancer - Mayo Clinic," n.d.). Colon cancer is a type of cancer that is inherited from FAP
(familial adenomatous polyposis) through mutated genes in APC (adenomas of the colon) as
Approximately 5-10% of individuals who develop colorectal cancer normally inherit the
gene defects that are responsible for the family cancer syndrome. The most popular inherited
syndrome affiliated with the colon cancer is the familial adenomatous polyposis (FAP) and the
Lynch syndrome although it has been noted that other rare syndromes can also increase chances
of contracting the disease. FAP is caused by mutations that occur in the APC gene as already
mentioned and this contributes to about 1% of colon cancer. The lynch syndrome, on the other
hand, accounts for approximately 2-4% of the colon cancers. This is caused by an inherited
A major critical step into understanding and finding the correct therapy for a disease is by
performing an accurate diagnosis of the disease. This would involve an understanding of the risk
factors and determining an effective treatment plan. Since colon cancer is hereditary, it is worth
looking at it from the perspectives of molecular genetics. Obtaining some knowledge about
polyp history is important in the pursuit of determining the malignant potential. Most colon
cancers arise from adenomas and patients with FAP stand a higher chance of contracting colon
cancer if colectomy is not performed. To understand about colon cancer, it is important to look at
sporadic cancer that causes genetic mutations contributing to disordered local DNA replication.
With progressive mutations in the genes, a transition from normal mucosa to benign adenoma
Conclusion
Since colon cancer has its roots from mutation leading inheritance of the disease, it is
important to understand the autonomy of this disease at cellular level as discussed by Dr. Terry
Buttaro in the Introduction to Advanced Pathophysiology presentation (2012). This would permit
the medical practitioners to gain a deeper understanding of the patients condition. If a medical
practitioner assumed any symptom and just went ahead to perform a diagnosis without thorough
examination, then the patient could stand a risk of experiencing other dire repercussions. As an
inheritable disease, becoming well acquainted with the genetics of this disease particularly the
sporadic part of it and understanding the cellular changes leading to signs and symptoms would
assist in advancing the nurses practice in providing the best therapy for the patients.
References
American Cancer Society, (2016). Colorectal cancer risk factors. Cancer.org. Retrieved 1
http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-
risk-factors
http://dx.doi.org/10.1016/j.gtc.2007.12.002
Huether, S. & McCance, K. (2012). Understanding Pathophysiology (1st ed.). St. Louis, Mo:
Elsevier.
Overview - Colon Cancer - Mayo Clinic. Mayoclinic.org. Retrieved 1 December 2016, from
http://www.mayoclinic.org/diseases-conditions/colon-cancer/home/ovc-20188216