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1. Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

By Kusmierz, Edyta; Siwek, Agata; Kosikowska, Urszula; Malm, Anna; Plech, Tomasz; Wrobel, Andrzej; Wujec,
Monika
From Phosphorus, Sulfur and Silicon and the Related Elements (2014), 189(10), 1539-1545. Language: English,
Database: CAPLUS, DOI:10.1080/10426507.2014.902831
Two series of thiosemicarbazide derivs. and three series of s-triazole derivs. have been synthesized. All of these
compds. were tested for their in vitro antibacterial activity against Gram-pos. and Gram-neg. bacterial strains. Among
tested thiosemicarbazide derivs., the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl
substitution (MICs range between 31.25 and 250 g/mL). All tested s-triazole derivs. exhibited lower antibacterial activity
than their acyclic precursors.
~1 Citing
Copyright 2016 American Chemical Society (ACS). All Rights Reserved.

2. Antibacterial characterization of 1-benzoyl-4-arylthiosemicarbazides and the study of their structure-activity

relationship
By Kusmierz, Edyta; Siwek, Agata; Kosikowska, Urszula; Malm, Anna; Wujec, Monika
From Letters in Drug Design & Discovery (2012), 9(9), 828-832. Language: English, Database: CAPLUS,
DOI:10.2174/157018012803307914
Series of 1-benzoyl-4-arylthiosemicarbazides were efficiently synthesized and evaluated for their antibacterial activities.
The results indicated that most of the compds. possessed activity against the Gram-pos. bacterial species. Some
structural and electronic parameters have been detd. to explore the correlation between the biol. activity and structure.
The mol. study suggests that inhibitory action of studied thiosemicarbazides towards Gram-pos. bacterial species is
connected with electronic parameters rather than the geometry of the mol.
~2 Citings

Copyright 2016 American Chemical Society (ACS). All Rights Reserved.