Five Upcoming Trends Within Cardiovascular

Research

Over the past several years, many changes took place in the
treatment of cardiovascular (CV) disease, which resulted in
marked decline in rates of morbidity and mortality.

In this article we write about 5 emerging trends within drug

research sector are highlighted each reinforces the need for
therapeutically centric, methodologically strenuous, and highly
efficient project teams for product assessment and
commercialization. These trends are:
 To recognise pleiotropic drug effects

Initiation of personalized/precision medicine

Effect of epigenetic and miRNA antisense oligonucleotide

therapeutics

Development of innovative trial methods for innovative

Interventions;

Academic, CRO, and pharma collaboration

1) CV Research in Pleiotropic Age

Drugs treating metabolic faults like dyslipidemias and type 2

diabetes mellitus are on the current scenario of treatments which
defined multiple effects assumed under the concept of pleiotropy.
The impact of type II diabetic therapy on the CV system prompts
concern and look after. The most recent target is the enzyme
dipeptidyl peptidase 4 (DPP-4).

2) Personalized Treatment

Personalized medicine gained success in oncology, but it faces

various challenges in CV disease where complex genetics,
environment and patient lifestyle comes together to create a unique
clinical presentation for each patient. It is more than a simple
genotype, but interplay of environmental factors with patient risk
factors that directs therapeutic decisions, and hence factors which
either confound or mediate beneficial therapeutic effects. The
several interplay of genes and environmental says that novel
therapies might work extremely well, but only in a few.

3) Epigenetics and MiRNA Antisense Oligonucleotide

Therapeutics

The amount of basic science research involving epigenetic effects

on RNA biology has expanded with knowledge of their role in
progress and prevention of disease. Scientific discoveries with
epigenetic changes in DNA methylation, histone modification, and
RNA biology affects the CV system and is creating the potential for
new therapeutic avenues.

4) Innovative Trial Methods

There is an emphasis about the necessity of re-evaluating

traditional trial designs and methods of execution. Even if trials
might not differ in treatment intervention, eligibility criteria, or
imaging assessments, it is commonly observed that patient
response in different geographical regions could exhibit marked
variation.

5) A natural extension of the science

Basic research, drug discovery and drug development are too often
viewed as being at different ends of a research and development
process. But the fact is that they are complementary and
enmeshed. CRO serves as a mediator of the process should
exemplify an ability to manage, facilitate, and support the interests
of various stakeholders and thus transforms the way clinical
research can be conducted.

We conclude the discussion here. Stay connected with us this space

for more discussions.

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