Dr.

Rajagopal

Annexure I

List of publications

1 Inhibition of RhoA-Dependent pathway and Contraction by Endogenous Hydrogen

Sulfide in Rabbit Gastric Smooth Muscle Cells (2015) Ancy D. Nalli, Senthilkumar
Rajagopal, Sunila Mahavadi, John R Grider, Karnam S Murthy American Journal of
Physiology; Cell Physiology 308:C485-C495

2 Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of

Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle
Relaxation (2015) Senthilkumar Rajagopal, Ancy D. Nalli, Divya P. Kumar, Sayak
Bhattacharya, Wehui hu, Sunila Mahavadi, John R Grider, Karnam S Murthy.
Journal of Pharmacology and Experimental Therapeutics 352(3):509-518

3 Chrysin enhances antioxidants and oxidative stress in L-NAME-induced

hypertensive rats (2015) Rm.Veerppan, *Senthilkumar Rajagopal. International
Journal of Nutrition, Pharmacology Neurological diseases 5(1):20-27

4 Release of GLP-1 and PYY in response to the activation of G-protein coupled bile
acid receptor TGR5 is mediated by Epac/PLC pathway and modulated by
endogenous H2S (2014) Vanitha bala*, Senthilkumar Rajagopal*, Divya P.Kumar,
Ancy D.Nalli, Sunila Mahavadi, Arun. J.Sanyal, John R.Grider, Karnam S.Murthy.
Frontiers in Physiology 5(420): 1-11 *Contributed equally to this work.

5 Inhibition of Protein kinase C response of voltage-gated calcium (Cav) 2.2 channels

expressed in xenopus oocytes by Cav subunits (2014) Senthilkumar Rajagopal,
Blanche L.Fields, Brittney K.Burton, Cansu On, Amellia A. Reeder, Amelia L.
Wilson and Gansean Kamatchi L. Neuroscience 280: 1-9

6 Contribution of Protein Kinase C Isozyme in the Stimulation of Insulin Secretion by

the Inhibition of Cav subunits (2014) Senthilkumar Rajagopal, Blanche L. Fields
and Ganesan L. Kamatchi Endocrine 47(2):463-471

7 Glycine stabilizes the tissue fatty acid composition in an experimental model of

alcohol-induced hepatotoxicity R. Senthilkumar (2014) Journal of Clinical and
Experimental Hepatology 4(2):S30-S31

8 Inhibition of RhoA/Rho Kinase Pathway and Contraction by Endogenous and

Exogenous Hydrogen Sulfide in Gastrointestinal Smooth Muscle (2013) Ancy D
Nalli, Senthilkumar Rajagopal, Sunila Mahavadi, John R Grider, Karnam S Murthy
FASEB Journal 27: 1164.2.

9 Differential regulation of muscarinic m2 and m3 receptor signaling in gastrointestinal

smooth muscle by caveolin-1 (2013) Sayak Bhattacharya, Sunila Mahavadi, Othman
Al-Shboul, Senthilkumar Rajagopal, John R. Grider, Karnam S.Murthy. American
Journal of Physiology; Cell Physiology 305(3): C334-47

10 Activation of G protein-coupled bile acid receptor, TGR5 induces muscle relaxation

via PKA- and Epac mediated inhibition of RhoA/Rho kinase pathway (2013)

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Senthilkumar Rajagopal, DivyaP.Kumar, Sunila Mahavadi, Sayak Bhattacharya,

Ruizhe Zhou, Carols Corvera, Nigel Bunnett, John R. Grider, Karnam S. Murthy.
American Journal of Physiology; Gastrointestinal and Liver Physiology 304: G527-
G535

11 Activation of transmembrane bile acid receptor TGR5 stimulates both insulin gene
transcription and insulin release in pancreatic cells (2012) Divya P. Kumar,
Senthilkumar Rajagopal, Sunila Mahavadi, Faridoddin Mirshahi, John R.Grider,
Karnam S. Murthy, Arun J. Sanyal Biochemical and Biophysical Research
Communication 427:600-605

12 Hydrogen Sulfide (H2S) Inhibits Bile Acid Receptor TGR5-Mediated GLP-1 Release
from Enteroendrocrine Cells: Possible Involvement of H2S in Altered Glucose
Metabolism in Diabetes (2012) Vanitha Bala, Senthilkumar Rajagopal, Divya P.
Kumar, Sunila Mahavadi, Ruizhe Zhou, Zachary L. Bradley, Nigel W Bunnett,
Carlos U. Corvera, Johan Auwerx, John R. Grider, Arun J. Sanyal, Karnam S. Murthy
Gastroenterology 142 (5): S-50

13 Characterization of Gz-Coupled Dopamine D3 Receptors in Gastric Smooth Muscle

(2012) Senthilkumar Rajagopal, DP Kumar, S Bhattacharya, JR Grider, KS Murthy
FASEB Journal 26: 1075.22

14 Bile Acid-Induced Stimulation of ERK1/2 Activity, GLP-1 and PYY Release in

Enteroendocrine Cells are mediated by the Activation of Epac/PLC- Signaling
Pathway via GS-Coupled TGR5 (2011) Vanitha Bala, Sunila Mahavadi,
Senthilkumar Rajagopal, Ruizhe Zhou, John F. Kuemmerle, Arun J. Sanyal,
Karnam S. Murthy Gastroenterology 140 (5): S-147

15 Expression and Function of Bile Acid Receptor TGR5 in Gastrointestinal Smooth

Muscle (2011) Senthilkumar Rajagopal, Othman Al-Shboul, Sunila Mahavadi, John
F Kuemmerle, Karnam S Murthy FASEB Journal 25: 1069.5

16 Differences in the Expression of VPAC2 Receptors and Adenylyl Cyclase V/VI and
VIP-Induced cAMP Generation in Phasic and Tonic Smooth Muscles (2011)
Othman Al-Shboul, Sunila Mahavadi, Senthilkumar Rajagopal, Ruizhe Zhou,
Karnam S Murthy FASEB Journal 25: 1069.7

17 Effects of Isoflurane on the Expressed Cav2.2 currents in Xenopus oocytes Depend

on the Activation of Protein Kinase C and its Phosphorylation Sites in the 12.2
Subunits (2011) Senthilkumar Rajagopal, Hongyu Fang, Carl Lynch III, Sando JJ
and Ganesan Kamatchi L Neuroscience 182: 232-240

18 Formalin -induced short and long-term modulation of Cav currents expressed in

Xenopus oocytes: An in vitro cellular model for formalin induced pain (2010)
Senthilkumar Rajagopal, Hongyu Fang, Carl Lynch III, Ganesan Kamatchi L.
Basic and Clinical Pharmacology and Toxicology 106: 338-347

19 Site-specific regulation of cav2.2 channels by protein kinase c Isozymes II and.

(2009) Senthilkumar Rajagopal, Hongyu Fang, Carlos Irwin A. Oronce, Shiel

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Jhaveri, Sonia Taneja, Eva M. Dehlin, Sandra L. Snyder, Julianne J. Sando, Ganesan
L. Kamatchi Neuroscience 159: 618-628

20 Protein kinase C Isozyme Specific Potentiation of Expressed CaV 2.3 Currents by

Acetyl--methylcholine and Phorbol-12-myristate, 13-acetate (2008) Senthilkumar
Rajagopal, Hongyu Fang, Saharat Patanavanich, George Varghese, Julianne J.
Sando, Ganesan L. Kamatchi Brain Research 1210: 1-10

21 Identification of the PKC isozymes involved in acetyl-beta-methylcholine or phorbol-

12-myristate, 13-acetate-induced potentiation of expressed Cav 2.3 currents (2007)
Senthilkumar Rajagopal, Hongyu Fang, Carl Lynch III, Julianne J Sando, Ganesan
L Kamatchi Biophysical Journal 1:602A-603A

22 Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2
currents by phorbol-12-myristate, 13-acetate (2006) Fang H, Patanavanich S,
Senthilkumar Rajagopal, Yi X, Gill MS, Sando JJ, Kamatchi GL The Journal of
Biological Chemistry 281(29): 20011-7

23 Modulatory influence of dietary resveratrol during different phases of a one, 2-

dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and
aberrant crypt foci development in rat colon carcinogenesis (2006) M.Sengottuvelan,
R.Senthilkumar, N.Nalini Biochimica Biophysica Acta 1760: 1175-1183

24 Effect of glycine on tissue fatty acid composition in an experimental model of

alcohol-induced hepatotoxicity (2004) R.Senthilkumar, N.Nalini Clinical and
Experimental Pharmacology and physiology 31(7): 456-461

25 Glycine ameliorates ethanol induced liver injury in albino rats (2004) R.

Senthilkumar, N.Nalini Alcohol Research 9(2): 63-70

26 Glycine prevent-s the hepatic fibrosis by preventing the accumulation of collagen in

alcohol induced liver injury (2004) R.Senthilkumar, N.Nalini Polish Journal of
Pharmacology 56(1): 121-128

27 The potential beneficial effect of glycine on the carbohydrate moieties of

glycoproteins in an experimental model of alcohol induced hepatotoxicity (2004) R.
Senthilkumar, N. Nalini Journal of Medicinal Food 7(1): 108-113

28 Glycine modulates lipids and lipoproteins levels in rats with alcoholic liver injury
(2004) R.Senthilkumar, N.Nalini Internet Journal of Pharmacology 2(2)

29 Effect of glycine on oxidative stress in rats with alcohol induced liver injury (2004)
R. Senthilkumar, P. Viswanathan, N. Nalini Die Pharmazie 59(1): 55-60

30 Protective effect of glycine supplementation on the levels of lipid peroxidation and

antioxidant enzymes in the erythrocyte of rats with alcohol induced liver injury
(2004) R.Senthilkumar, M.Sengottuvelan, N. Nalini Cell Biochemistry and
Function 22(2): 123-128

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31 Glycine modulates hepatic lipid accumulation in alcohol induced liver injury (2003)
R. Senthilkumar, P. Viswanathan, N. Nalini Polish Journal of Pharmacology 55(4):
603-611

32 Antioxidant activity of Cassia auriculata in rats with alcoholic liver injury (2003) R.
Senthilkumar, M. Ponmozhi, P. Viswanathan, N. Nalini Journal of Nutritional
Biochemistry 14(8): 452-458

33 Effect of Cassia auriculata leaf extract on lipids in rats with alcoholic liver injury
(2002) R.Senthilkumar, M. Ponmozhi, P. Viswanathan, N. Nalini Asia Pacific
Journal of Clinical Nutrition 11(2); 157-163

34 Hypolipidemic Effect of Black pepper (Piper nigrum Linn.) in Rats Fed High Fat
Diet (2002) R.S. Vijayakumar, D.Surya, R.Senthilkumar, N. Nalini Journal of
Clinical Biochemistry and Nutrition 32: 31-42

35 Hypolipidemic effect of cuminun cyminum L. on alloxan induced diabetic rats (2002)

D.Surya, R.S. Vijayakumar, R. Senthilkumar, N. Nalini. Pharmacological Research
46(5): 11-15

36 Effect of Chrysin on the Cardiovascular Risk of N-nitro-l-arginine-methylester

induced hypertensive rats (2015) Veerappan Ramanathan, Supraj Raja Sangam,
Shubham singh, Senthilkumar Rajagopal Cell Biochemistry and Function 2015
(Accepted).

Review Article
37 Alcohol, Glycine and Gastritis (2015) Shubham Singh, Supraj Raja Sangam,
Venkateshwara Rao Joginapally, Senthilkumar Rajagopal. International Journal of
Nutrition, Pharmacology, Neurological Diseases 5(1):1-5

38 Mitochondrial abnormalities and pathways of cancer (2014) Sangam S and

Rajagopal S Research Journal of Recent Sciences 3(ISC-2013):1-6

39 Differential regulation of anesthetics on ion channels (2015) Senthilkumar

Rajagopal, Supraj Raja Sangam, Shubham Singh International Journal of Nutrition,
Pharmacology, Neurological Diseases (In Press).

Mini Review Article

40 Alcohol-induced Gastric inflammation (2015) Shubham Singh, Supraj Raja Sangam,
Venkateshwara Rao Joginapally, Senthilkumar Rajagopal Journal of
Pharmaceutical and Biomedical Sciences 5(2):174-177

Short Communication
41 Contribution of Protein Kinase C (PKC) in the modulation of Voltage gated Calcium
Channels (2015) Senthilkumar Rajagopal, Shubham Singh, Supraj Raja Sangam
Journal of Pharmaceutical and Biomedical Sciences 5(4):351-354

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Book Chapters
1. N. Nalini, M. Ponmozhi and R. Senthilkumar. (2001). Effect of Phaseolus vulgaris
extraction lipid metabolism in experimental diabetes mellitus. In: Rajeev Gupta (edi).
Current Advances in Atherosclerosis Research. Vol. IV. Pp. 113-124.

2. R. Senthilkumar*. (2013). Amino Acids from Food as Medicine: Valuable Function.

Chapter 22; Pp: 411-42. In: M. Mohammed Essa and Mushtaq A. Memon (Eds).
Food as Medicine. Nova Publications, New York, USA. ISBN: 978-1-62417-747-7.
Book Series title: Food Science and Technology. *Corresponding author

3. Senthilkumar Rajagopal*, Venkateshwara Rao Joginapally, Timiri Shanmugam

Prakash Srinivasan, Veerappan Ramanathan (2014). Beneficial Effects of Dietary
Amino acids on Brain Health. Chapter 19, Pp: 221-24. 1In: M.Mohammed Essa and
Mushtaq A. Memon (Eds). Food and brain Function. Nova Publications, New York,
USA. ISBN: 978-1-63117-734-7. Book Series title: Food and Beverage
Consumption and Health. A) Got Special award from Society of Neuroscience,
Washington, D.C., USA in the field of Nutrition and Health
B) 3rd prize Gourmand World Cookbook Awards 2015, China.

4. Senthilkumar Rajagopal*, Supraj Raja sangam, Shubham Singh, Venkateshwara

Rao Joginapally. (2015). Alcohol-induced Hepatotoxicity; Symptoms and
Management. Chapter 1, Pp: 1-22. In: Senthilkumar Rajagopal and Sengottuvelan
Murugan (Eds). Hepatotoxicity, Symptoms, Management and Health
Implications. Nova Publications, New York, USA. [Selectively Invited book].
ISBN: 978-1-63482-650-1. Book Series title: Hepatology Research and Clinical
Developments. *Corresponding author & Editor.

5. Timiri Shanmugam Prakash Srinivasan, Senthilkumar Rajagopal (2015).

Hepatocarcinogenicity of Aflatoxin-B1. Chapter 11, Pp: 229-246. In: Senthilkumar
Rajagopal and M.Sengottuvelan (Eds). Hepatotoxicity, Symptoms, Management
and Health Implications. Nova Publications, New York, USA. ISBN: 978-1-63482-
650-1. Book Series title: Hepatology Research and Clinical Developments.

6. Sabina Fatima, Senthilkumar Rajagopal. (2015). Burdon of Bacterial Bio-films on

Hepatocytes. Chapter 12, Pp: 247-264. In: Senthilkumar Rajagopal and
M.Sengottuvelan (Eds). Hepatotoxicity, Symptoms, Management and Health
Implications. Nova Publications, New York, USA. ISBN: 978-1-63482-650-1. Book
Series title: Hepatology Research and Clinical Developments.

7. Senthilkumar Rajagopal*, Supraj Raja sangam, Shubham Singh, Venkateswara Rao

Joginapally. (2015). Modulatory effects of Dietary amino acids on neurodegenerative
diseases. In: M.Mohammed Essa, Gilles J.Guillemin and Mohamed Akbar (Eds). The
Benefits of Natural Products for Neurodegenerative Diseases. Springer
Publications, New York, USA; Book Series Title: Advances in Neurobiology. Series
Ed.: Schousboe, Arne. ISSN: 2190-5215. (Submitted). * Corresponding author

8. Shubham Singh, Supraj Raja sangam, Senthilkumar Rajagopal*. (2015).

Regulatory Role of Nanoparticles on G-protein coupled receptor activation. In: Alex
Mihai Grumczescu (Edi). Nutrition. Elsevier Publications, London, UK; Book

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Series Title: Food Science and Food industry. (In preparation). * Corresponding
author