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PREPARING
CHEMOTHERAPEUTIC
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DRUGS
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SUBMITTED TO: Ms. Ivy Jade
Castaos,RN,MAN
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SUBMITTED BY: Capendit,
Sunshine BSN IV
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IV
Nuez, Mary Joy BSN
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OBJECTIVES
After 8 hours of classroom discussion and demonstration, the Level IV
students will be able to:
Metastasis- spread of cancer cells from the primary tumor to distant sites
Benign- not cancerous; benign tumors may grow but are unable to spread to
other areas
Cell Life Cycle- is the series of changes a cell goes through from the time it
is formed until it divides
Interphase- the cell grows and carries on its usual metabolic activities
Mitosis results in the formation of two daughter nuclei with exactly the
same genes as the mother nucleus
Stages of Mitosis
Prophase- Chromatin in the nucleus begins to condense and becomes
visible in the light microscope as chromosomes. The nucleolus disappears.
Centrioles begin moving to opposite ends of the cell and fibers extend from
the centromeres. Some fibers cross the cell to form the mitotic spindle.
PURPOSE OF CHEMOTHERAPY
Cure cancer
when chemotherapy destroys cancer cells to the point that your doctor
can no longer detect them in your body and they will not grow back
Control cancer
Types of Chemotherapy
1. Single-agent chemotherapy
2. Combination chemotherapy
Means the use of two or more chemotherapy drugs for the purpose of
treating cancer. It is the most effective method used for treating
various types of cancer and also helps to relieve the symptoms of this
disease.
Indications of Chemotherapy
Mitotic Spindle
Poisons Arrest Cell cycle- Bone marrow
Plant alkaloids: metaphase by nonspecifi suppression
etoposide, teniposide, inhibiting mitotic c (mild with VCR),
vinblastine, vincristine tubular formation (M phase) neuropathies
(VCR), vindesine, (spindle); inhibit (VCR), stomatitis
vinorelbine DNA and protein Bradycardia,
Cell cycle-
synthesis hypersensitivity
Taxanes: paclitaxel, nonspecifi
Arrest reactions, bone
docetaxel c
metaphase by marrow
(M phase)
inhibiting tubulin suppression,
depolymerization alopecia,
neuropathies
Management
2. Nausea, vomiting and diarrhea- most common side effects because the
vomiting centers in the brain are stimulated
Management
antiemetic medication
small frequent meals
bland foods
relaxation techniques and imagery
Management
frequent monitoring of blood cell count
protect patient from infection and injury
agents with colony stimulating factor(erythropoietin) can be
administered after chemotherapy
Management
Management
Management
During
put on gloves
disinfect drug with cotton ball with alcohol
prepare the drug
hand over the syringe to the doctor
close the IV line
monitor patient's reaction and vital sign while the doctor is infusing the
drug
After