Escolar Documentos
Profissional Documentos
Cultura Documentos
ADENOIDAL HYPERTROPHY
SCOPE OF THE PRACTICE GUIDELINE
This clinical practice guideline is for use by the Philippine Society of Otolaryngology-Head and
Neck Surgery. It covers the diagnosis and management of acute and chronic tonsillopharyngitis
and obstructive adenoidal hypertrophy in adults and children.
OBJECTIVES
The objectives of the guideline are (1) to describe clinical and epidemiologic features of tonsillitis
in children and adults including socioeconomic burden of disease; (2) to enumerate current
diagnostic techniques, and (3) to describe treatment options.
LITERATURE SEARCH
This guideline is based on the Clinical Practice Guidelines of the Philippine Society of
Otorhinolaryngology Head and Neck Surgery (1996) on Acute and Chronic Tonsillitis. This was
updated using available articles published in the past 10 years as found in The National Library of
Medicines PubMed database using the keyword tonsillitis. The search was limited to English
language articles involving humans. The search yielded 161 articles which were carefully
screened for relevance to the guideline. Of these, ninety-two (92) abstracts were selected and full
text journals were obtained whenever possible. In addition, several guidelines on sore
throat/pharyngitis and indications for tonsillectomy were included. These are the: Clinical Practice
Guideline on Tonsillitis by the American Academy of Otolaryngology-Head and Neck Surgery;
Clinical Practice Guidelines on the Management of Sore Throat of the Academy of Medicine
Malaysia (2003); National Clinical Guideline on the Management of Sore Throat and Indications
for Tonsillectomy of the Scottish Intercollegiate Guidelines Network (1999); Practice Guidelines
for the Diagnosis and Management of Group A Streptococcal Pharyngitis of the Infectious
Disease Society of America (2002); Practice Guidelines on the Diagnosis and Management of
Group A Streptococcal Pharyngitis of the American Family Physician (2003); Guideline on Sore
Throat and Tonsillitis of the Finnish Medical Society Duodecim (2004). The chosen articles were
divided as follows:
Meta-analysis 24
Randomized controlled trial 17
Non-randomized controlled study 7
Descriptive study 33
Committee report 12
Guidelines 6
DEFINITIONS
Acute Tonsillopharyngitis the presence of erythematous and/or exudative tonsils with any
one of the following symptoms: sore throat, dysphagia, odynophagia, fever and accompanying
tender, enlarged cervical lymph nodes.
The panel further deliberated on whether tonsillitis with signs but without symptoms or
conversely with symptoms but without signs should be admitted in the definition.
However, neither the situation can be reliably taken to mean proof of tonsillar
inflammation and the criteria was considered broad enough to include much of the clinical
spectrum of acute tonsillar infection. Imposing a time frame for the development of
symptoms as an additional diagnostic criterion was also considered but disregarded
since available evidence does not support a definite clinically recognizable period beyond
which acute tonsillitis can be justifiably labeled chronic or persistent in the oropharynx,
oral cavity or systemically.
(comment: separate definitions for Acute Pharyngitis and Acute Tonsillitis Panel consensus
was that both terms can be integrated into one and that recommendations for either are the
same)
Viral tonsillopharyngitis inflammatory condition of the tonsils caused by respiratory viruses
such as adenovirus, influenza, parainfluenza, and respiratory syncitial virus. Other viral agents
1,22
include coxsackie, echoviruses, herpes simplex and Epstein Barr Virus (EBV).
The study by Paradise et. al. (1993) demonstrated that patient recall of the number of
sore throat episodes grossly overestimates the frequency of subsequent episodes. While
the study may be prone to maturation bias (i.e., the patients really got better with time) it
does question the validity of patients (or parental) recall when unverified by medical
consultation. Even medical validation is no guarantee of true tonsillitis because of the
lack of a widely accepted clinical definition among general practitioners, pediatricians and
otolaryngologists.
The degree of obstruction may be expressed in terms of Clinically Assessed Size (CAS)
scale in which the distance between the tonsils and the distance between the anterior
tonsillar pillars are measured while the tongue is gently depressed. The ratio between the
two is a measure of tonsillar encroachment on oropharyngeal space. While the scale
lacks clinical validity at present the panel recognized its potential for standardizing
tonsillar examination findings.
It is estimated that approximately 50% of cases of acute pharyngotonsillitis have a viral etiology.
In 15 20% of cases, a primary bacterial pathogen, most commonly a streptococcal organism is
recovered (Discolo 2003). Epidemiological data from western countries, in general, as specifically
GABHS infections, both community and hospital based are more readily available. However,
there is considerable variation in the prevalence of GABHS sore throats from one country to
another. In Dhaka, Bangladesh, 22% of 601 children studied had a positive culture but only 2.2%
was due to GABHS (Faruq 1995). In Israel, the prevalence is 15% among 152 symptomatic
children aged 3 months to 5 years of age (Amir 1994). In the Italian French study, 26% of 865
children from 5 months to 14 years had GABHS pharyngitis (Cauwenberge 1999). Overall, he
figure is less than 30% in most countries. In the adult population GABHS is responsible for 5-10%
of cases of acute pharyngitis (Bisno 2001).
In our local setting, the Philippine General Hospital Out Patient Department ORL Clinic had 10
consults for Acute Tonsillitis, 4 consults for Acute Pharyngitis, and 21 consults for Acute
Tonsillopharyngitis and 76 consults for Chronic Hypertrophic Tonsils out of 13,517 patients
during the period of January to May of 2005. The prevalence rate is 7 out of 1000 patients for
Acute Tonsillitis, 3 out of 1000 patients for Acute Pharyngitis, 15 out of 1000 patients for Acute
Tonsillopharyngitis, and 56 out of 1000 patients for Chronic Hypertrophic Tonsils from January to
May of 2005 (Table 1).
Chronic Total
Acute Acute Acute
Hypertrophic OPD
Tonsillitis Pharyngitis Tonsillopharyngitis
Tonsils consults
Consults 10 4 21 76 13,517
Prevalence 7 / 1000 3 / 1000 15 / 1000 56 / 1000 ----------
In the University of Perpetual Help Binan and Rizal and Sta. Rosa Polyclinic and Community
Hospital 4,080 patients with ages ranging from 1 to 18 years old, and 680 age >19 years old were
referred to the Out Patient Department of these institutions for tonsillitis in 2004. They admitted
148 patients from these for peritonsillar abscess. For the University of Sto. Tomas (UST)-Out
Patient Department, they had 3,456 consults for tonsillitis in 2004 for both pediatric and adult
patients. 85 of these patients subsequently underwent surgery.
The economic impact of tonsillitis locally is not known due to paucity of studies. Research from
other countries may provide insight into the socioeconomic impact of this condition. In the adult
population, about 6.7 million visits annually were for sore throat (Barlet 1997). In the UK, it is
estimated that visits for consultation for sore throat alone cost the NHS 60 million pounds per
annum (National Ambulatory Medical Care Survey 1989-1999).
1. The diagnosis of acute tonsillopharyngitis may be made clinically for both children
and adults. It is important to differentiate whether the infection is viral or bacterial in
etiology.
Grade B Recommendation
Approximately 30 to 60% have a viral etiology (rhinovirus, adenovirus, and others) only 5
to 10% are caused by bacteria, with Group A beta-hemolytic streptococci being the most
common bacterial etiology. In Hongkong, 2.65% of those more than 14 years of age have
GABHS pharyngitis. In the US, the 1988 prevalence rates of recurrent tonsillitis was 14.9%
among white non-Hispanics, 6.5% among black non-Hispanics and 10.2% among Hispanics
2
(1988 National Health Survey on Child Health, US) .
There are several reasonable approaches to the diagnosis of GABHS in an otherwise healthy
adult, such as use of clinical criteria alone or use of rapid antigen testing as an adjunct to
clinical screening. Either of these strategies is associated with reasonable diagnostic
accuracy (approximate sensitivity > 70%, specificity > 70% and allows treatment decisions to
3
be made early in the course of illness, when patients can receive symptomatic benefit . (refer
to Table 2)
1,16
Table 2. Clinical features of acute tonsillopharyngitis
Grade B Recommendation
2.1. Throat culture remains to be the gold standard for the diagnosis of streptococcal
9
pharyngitis with a sensitivity of 90-95%.
Grade B Recommendation
2.2. A positive rapid antigen detection test (RADT) may be considered definitive
evidence for treatment of streptococcal pharyngitis, with specificity of 95% and
sensitivity of 89.1%. These values are similar to those of throat culture which has
a 99% specificity and 83.4% sensitivity. RADT, however, is not widely available
1
locally and cannot be considered part of routine diagnostic assessment.
Grade C Recommendation
Grade C Recommendation
2.4. However, the value of early diagnosis in the minority of cases when
streptococcus is present should be weighed against the higher cost incurred in
testing the majority of cases seen. Selective use of diagnostic studies is
8
suggested.
Consequent to the risk of complications developing from untreated GABHS
infection, early diagnosis and appropriate antimicrobial treatment is warranted.
Attempts to study the predictive value of the various signs and symptoms have
19
not been particularly reliable.
Grade C Recommendation
Grade C Recommendation
There are four randomized controlled trials (RCT) on tonsillectomy versus non-surgical
intervention studies in children but no RCT in adults. Scottish Intercollegiate Guidelines
Network advised more than 5 episodes and American Academy of Otolaryngology-Head and
Neck Surgery more than 3 episodes as indication for tonsillectomy. Non-controlled studies
demonstrated reduction in number of sore throats and improved general health with
tonsillectomy. The panel concensus for this CPG is at least 4 episodes a year.
Grade C Recommendation
Management includes symptomatic treatment, antibiotic therapy for GABHS pharyngitis and, if
clinically indicated, surgical treatment.
Grade B Recommendation
Grade A Recommendation
2. Antimicrobial therapy is indicated for patients with acute bacterial tonsillitis based on
clinical and epidemiological findings with/without supported by laboratory
27
examinations.
Grade A Recommendation
Early antibiotic therapy will suppress rapidly infection and lower the risk of transmission within
24 hours allowing children to return to school. Untreated patients usually will improve in 3 5
28
days unless a complication develops .
The majority of the studies and guidelines mostly involved patients with acute
tonsillopharyngitis.
2.1. Penicillin is the drug of choice for the treatment of streptococcal pharyngitis. The
antibiotic has proven efficacy and safety, a narrow spectrum of activity and low
cost.
Grade A Recommendation
2.2.First Generation Cephalosporins may be used instead of penicillin but may be more
nd st
expensive. 2 Generation Cephalosporins are as effective as 1 Geneneration
st
Cephalosporin but may be more expensive than both Penicillins and 1 Generation
31
Cephalosporin deleted phrase(are therefore not recommended).
Grade B Recommendation
Grade A Recommendation
2.4. Erythromycin (Pediatric dose: 30-50 mg/kg/day in 4 divided doses, Adult dose: 1-2
g/day in 4 divided doses) is a suitable alternative for patients allergic to penicillin
who manifest hypersensitivity to beta lactam antibiotics.
Grade C Recommendation
2.5. Failure to resolve the infection within 3-4 days justifies shifting to augmented
rd
penicillins, clindamycin, 3 generation cephalosporins or higher generation
macrolides. Higher generation macrolides may be used for 3-5 days.
Grade C Recommendation
Grade C Recommendation
3.4. Patients with the following conditions may benefit from adenoidectomy
Grade C Recommendation
3.5. New surgical modalities for tonsillectomy may be available but are not
recommended as routine procedures because of higher expense deleted
phrase(unproven effectiveness). These include coblation, radiofrequency and
11,13,14,15,16
ultrasonic harmonic scalpel.
Grade C Recommendation
Grade C recommendation