Escolar Documentos
Profissional Documentos
Cultura Documentos
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
2020
PORTFOLIO
facebook.com/unemedcorp
twitter.com/unemed
bit.ly/UNeMedVideo
bit.ly/UNePics
bit.ly/UNeMedLink
402-559-2468
unemed@unmc.edu
http://www.unemed.com
Mail:
986099 Nebraska Medical Center
Omaha, Nebraska 68198-6099
Location:
4460 Farnam St., Ste. 3000
Omaha, Nebraska 68198-6099
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
Contents PORTFOLIO
cancer........................... 2
cardiovascular........... 12
drug delivery.............. 16
infectious diseases.... 22
medical devices......... 42
metabolic................... 78
miscellaneous............ 81
neurologic.................. 91
research tools............ 94
software................... 111
startups.................... 121
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
3
2020
University of Nebraska Medical Center
PORTFOLIO CANCER
Cancer classification algorithm
Identify critical cancer
biomarkers with a single sample
A new and powerful algorithm could help
in the diagnosis and prognosis of any Powerful prognosis,
cancer.
diagnosis tool
The discovery of cancer-specific gene n Reference based meth-
od for gene biomarker
biomarkers can significantly improve
discovery
diagnosis and enable personalized n Classify cancer type
Cancer
therapy. Unlike current cancer screening using gene expression
strategies that are largely based on data
imaging techniques, this algorithm n Diagnosis, prognosis
represents a purely data-driven method from a single clinical
to identify biomarkers. sample
n Novel algorithm re-
Unlike other gene discovery algorithms quires no prior knowl-
under development, this technology edge to use
requires relatively less processing
INVENTORS
power, yet provides true single-sample n Amar Singh, Ph.D.
diagnostic potential. Plus, the novel n Dhundy Bastola, Ph.D.
software is easy to use, and does not n Ling Zhang, Ph.D.
require medical knowledge for the user.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
4 TECHNOLOGY
2020
University of Nebraska at Omaha
CANCER PORTFOLIO
By systematically
analyzing 39,000
genes present in 437 clinical samples across 13 clinical datasets,
researchers at the University of Nebraska at Omaha identified a
unique 135-gene profile unique to
Track in real time this rare form of splenic lymphoma.
n Novel biomarkers for Intriguingly, separate subsets of seven
splenic marginal zone and two biomarkers were demonstrated
lymphoma to be greater than 93 percent accurate at
n Positively diagnose diagnosing splenic lymphoma versus all
SMZL from all other other B-cell lymphomas.
B-cell lymphomas
n Measure biomarkers Unlike most diagnostics, these
in blood and in fresh
biomarkers can be measured in blood as
or preserved splenic
biopsies well as fresh or preserved tissue samples.
n Potential to monitor
SMZL progression in With further validation, these biomarkers
real-time could also be used to monitor splenic
lymphoma progression and metastasis in
INVENTORS real-time, enabling oncologists to provide
n Christine Cutucache, timely and effective treatment.
Ph.D.
n Jacob Robinson, Ph.D.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
Microtubule targeting
New compounds allow
imaging, treatment of cancer
UNMC researchers have developed New Compounds to
compounds that are capable of not only
imaging and monitoring tumors, but treat, image cancer
treating them as well. n Microtubule-targeted
radiopharmaceuticals
n Images and treats
The new compounds specifically bind
cancer
Cancer
to protein-based structures called n Non-radioactive forms
microtubules. Microtubules play a critical of the drugs can
role in a number of cellular functions, induce cell death
and are a key target for treating a variety n Can be labeled with a
of cancers. variety of radionuclides
Microtubule-targeted
compounds labeled with
iodine-131 were tested
in a mouse model of
glioblastoma. Treatment
with the compound
significantly reduced tumor
size and weight. Additional
studies will look at the use
of other radionuclides such
as astatine-211.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
CANCER PORTFOLIO
teamed up to develop
new drugs to help treat
multiple myeloma and
other types of cancer.
GGDPS is involved in
the regulation of the
Rab family of small but important proteins that are also often linked to
cancer: GTPases. Targeting GGDPS may provide a way to inhibit Rab
family proteins, providing a
GGDPS Inhibitors unique way to treat various
forms of cancer.
n Small molecule inhibitors of GGDPS
n Nanomolar potency
n Novel treatment approach for multiple
The new GGDPS inhibitors
myeloma and other cancers have nanomolar potency
and are being assessed
INVENTORS in vivo to determine
n David Weimer, Ph.D. pharmacokinetics
n Sarah Holstein, Ph.D. properties and efficacy.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
Cancer
key target involved in a
variety of cancers and
other diseases.
UNeMed is interested in
New Compounds to treat cancer forming collaborations with
n Inhibits the NF-κB pathway industry to further explore
n Causes degradation of IKKβ and IKKα the potential of 36-252
n Nanomolar potency in cell-based as a novel therapy of the
studies treatment of cancer and
other diseases associated
INVENTORS
n Amarnath Natarajan, Ph.D. with overactive NF-κB.
n Sandeep Rana, Ph.D.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
CANCER PORTFOLIO
Dr. Batra’s research shows that shutting down PD2 could make
once-resistant cells vulnerable to cancer drugs. When PD2 was
inhibited, drug-resistant cells became susceptible to treatment with
the chemotherapy drug Gemcitabine. The results suggest PD2 may
be a compelling target for more effective cancer treatment.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
9
2020
University of Nebraska Medical Center
PORTFOLIO CANCER
CCL21-based immunotherapy for cancer
Use the immune system to
infiltrate and destroy tumors
University of Nebraska Medical Center researchers have found a way
to harness the power of the immune system to recruit immune cells to
help treat cancer.
Tatiana Bronich, Ph.D., and Joyce Solheim, Ph.D., have shown that
a protein messenger, or chemokine, called CCL21 can be used to
treat tumors. CCL21 is capable of attracting immune cells to the area
Cancer
where it’s administered.
However, one problem with this approach is that CCL21 doesn’t last
long inside the body, and therefore the effects of CCL21 are relatively
short-lived.
Personal option for
To get around this hurdle, Drs. Bronich cancer treatments
and Solheim created a new way to
deliver CCL21 directly to the tumor site n Personalized immuno-
while protecting it from degradation. The therapy
nanoformulation allows for extended n Extended release formu-
release of CCL21 within the tumor site, lation
which prolongs its effect and increases n Enhance existing immu-
the overall therapeutic impact. notherapies
INVENTORS
The CCL21 nanoparticle formulations
n Tatiana Bronich, Ph.D.
have been developed, and release n Joyce Solheim, Ph.D.
kinetics have been optimized.
Researchers have also performed small-
scale animal studies using subcutaneous Panc02 tumors where the
nanoformulated CCL21 showed significant inhibition of tumor growth
over nine days.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
10 TECHNOLOGY
2020
University of Nebraska Medical Center
CANCER PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
11
2020
University of Nebraska Medical Center
PORTFOLIO CANCER
Nanogel cancer treatment
Nanogel delivers cancer
treatment with fewer side effects
A new nanogel under
development at the
University of Nebraska
Medical Center may
dramatically reduce the
multitude of adverse
side effects often
Cancer
associated with modern
cancer treatments.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
13
2020
University of Nebraska Medical Center
PORTFOLIO CARDIOVASCULAR
Sympathetic vasomotion monitoring
New device will improve outcomes
Cardiovascular
in renal denervation procedures
Researchers at UNMC developed a
device capable of making high blood Rundown
n Detects small changes
pressure more treatable by accurately
n Measures success of
measuring the rhythmic constriction renal denervation
and relaxation of blood vessels, known n Increase success rate
as sympathetic vasomotion. n Can screen for blood
pressure-related fainting
The sympathetic nervous system n non-invasive
controls the body’s automated hemodynamic
functions such as digestion, heart rate monitoring
and the vasomotion of blood vessels.
Disruption of the sympathetic nervous INVENTORS
n Irving Zucker, Ph.D.
system can contribute to a variety of
n Alicia Schiller
chronic diseases, including high blood n Peter Pellegrino
pressure.
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
14 TECHNOLOGY
2020
University of Nebraska Medical Center
CARDIOVASCULAR PORTFOLIO
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
Cardiovascular
Many babies born with congenital defects of the heart now live to
become adults. Pediatric congenital heart disease and the heart
defects that it produces used to be completely lethal. Surgery for
congenital heart defects can now correct the majority of these
heart defects in infants.
Treatment of heart
defects in infants Managing congenital heart disease
n No deviation from current correction of
came from tireless congenital heart defects
innovation for congenital n Improved access for better manage-
heart defect surgery ment
and the combined n Easier to use, more efficient
expertise of teams
of medical experts. INVENTOR
Pediatric cardiologist n Jeff Delaney, M.D.
Jeffrey Delaney MD
and pediatric thoracic
surgeon James Hammel MD embody that innovation.
Dr. Hammel surgically corrects birth defects of the heart and Dr.
Delaney manages children living with congenital defects of the
heart. Their collaboration is the kind of care that has produced the
first generation of adults with congenital heart disease.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
17
2020
University of Nebraska Medical Center
PORTFOLIO DRUG DELIVERY
CCL21-based immunotherapy
Use the immune system to
infiltrate and destroy tumors
Drug Delivery
University of Nebraska Medical Center researchers have found a way
to harness the power of the immune system to recruit immune cells
to help treat cancer.
Tatiana Bronich, Ph.D., and Joyce Solheim, Ph.D., have shown that
a protein messenger, or chemokine, called CCL21 can be used to
treat tumors. CCL21 is capable of attracting immune cells to the area
where it’s administered.
However, one problem with this approach is that CCL21 doesn’t last
long inside the body, and therefore the effects of CCL21 are relatively
short-lived.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
18 TECHNOLOGY
2020
University of Nebraska Medical Center
DRUG DELIVERY PORTFOLIO
Initial animal
studies have Anti-inflammatory polymers for IBD
been conducted
demonstrating n Orally administered therapy for IBD
localization of n Targeted to the digestive system
orally administered n Decreased dosing for ART therapy
chloroquine-based n Capable of packaging and delivering
polymers to the additional drugs
digestive tract.
INVENTORS
n David Oupicky, M.D.
n Fei Yu, Ph.D.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
19
2020
University of Nebraska Medical Center
PORTFOLIO DRUG DELIVERY
Long-acting antiretroviral therapy
New delivery method opens
powerful option for HIV treatment
Drug Delivery
Researchers at the University of Nebraska Medical Center have
discovered a way to revolutionize the treatment of HIV. Early studies
show UNMC’s novel approach could reduce the regimen to a single
treatment once every month, eliminating the need for current strategies
that require daily administration of medicine.
Early tests on mouse models and large animals show that LaserART
produces a sustained release with long-lasting antiretroviral activity.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
DRUG DELIVERY PORTFOLIO
Nanofiber rings
Implant, customize drug delivery device
Researchers at the University
Drug Delivery
of Nebraska Medical
Center have developed
a new implantable drug
delivery device made out of
nanofibers.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
21
2020
University of Nebraska Medical Center
PORTFOLIO DRUG DELIVERY
Nanogel cancer treatment
Nanogel delivers cancer
treatment with fewer side effects
Drug Delivery
A new nanogel
under development
at the University
of Nebraska
Medical Center may
dramatically reduce
the multitude of
adverse side effects
often associated
with modern cancer
treatments.
Most cancer
treatments require a
strategy that incorporates a combination of therapies, which can
be detrimental to the patient’s health. Until now there haven’t been
many effective ways to specifically target cancerous cells.
Proof of principle
studies show
Target cancer sites the nanogel
can effectively
n Novel nanogel formulation deliver multiple
n Allows for targeted delivery of multiple drugs chemotherapy
n Allows for a lowered effective dose
n Minimizes side effects
drugs, and can
n Targets cancer cells also be used with
a wide range of
INVENTORS drugs and drug
n Tatiana Bronich, Ph.D. classes, including
n Alexander Kabanov, Ph.D. peptides, proteins
and gene therapy
agents.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
Infectious Diseases
powerful option for HIV treatment
Researchers at the University of Nebraska Medical Center have
discovered a way to revolutionize the treatment of HIV. Early studies
show UNMC’s novel approach could reduce the regimen to a single
treatment once every month, eliminating the need for current strategies
that require daily administration of medicine.
Antiretroviral therapies,
or ART, are also Nano-formulated antiretroviral
ineffective at reaching
viral reservoirs such as therapy for the treatment of HIV
the lymph nodes and
n Sustained delivery of antiretroviral drugs
the central nervous
n Increased penetration into viral reservoirs
system. These viral n Decreased dosing for ART therapy
reservoirs essentially n Less frequent dosing for ART therapy
serve as a bunkers that
shelter HIV from current INVENTORS
medications. But UNMC n Howard Gendelman, M.D.
researchers overcame n Alexander V. Kabanov, Ph.D.
this obstacle with a new n Xinming Liu, Ph.D.
nanoformulation called
LaserART.
Early tests on mouse models and large animals show that LaserART
produces a sustained release with long-lasting antiretroviral activity.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
25
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
Targeted biofilm prevention
Prevent, treat biofilms by
Infectious Diseases
targeting the immune system
More than a million
cases of hospital-
acquired infections
can be traced to
biofilm, a slimy
coating of microbes
that can form on
medical devices and
implants.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
26 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
Antibacterial compounds
Infectious Diseases
New compounds fight
antibiotic resistant bacteria
Researchers at the University of Nebraska Medical Center have
developed a set of promising antibacterial compounds that can
effectively wipeout bacteria such as MRSA and anthrax.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
27
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
Antimicrobial peptides
Imbue orthopedic implants
Infectious Diseases
with primary immunity
All orthopedic implants, such as hip or knee replacements,
eventually fail. But if an implant gets infected it fails much more
rapidly and can even lead to death. Researchers at the University
of Nebraska Medical Center discovered a new way to prevent
implant-associated biofilm infections. Guangshun Wang, Ph.D.,
designed antimicrobial peptides to coat the surface of metallic
orthopedic implants and specifically target antibiotic resistant
infections known as MRSA or methicillin-resistant Staphylococcus
aureus. Not only do the novel proteins prevent MRSA biofilm
formation, but they also recruit host immune cells to help clear any
opportunistic bacteria.
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
28 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Hand guard slit lamp shield
New guard protects
Infectious Diseases
opthamologists’ hands
New guard protects opthamologists’ hands
during exams Rundown
n Protects
opthamologists’
An opthalmologist from the University of
hands during an
Nebraska Medical Center has developed a optometric exam
slit lamp shield that can protect the patient n Easy to remove,
and examiner from respiratory droplets clean between
during an opthalmic or optometric exam. patients
This new design of the slit lamp shield
provides excellent coverage of the examiners INVENTOR
hands while retaining its universal use. n Rao Chundry
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
29
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
Z-filter Device COVID-19
Infectious Diseases
particles during treatments
Clinicians from the University of
Nebraska Medical Center have
developed the Z-filter, a device
that mitigates the release of
infectious aerosolized particles
during nebulizing treatments.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Modular Electronic Decision Support Builder
Infectious Diseases
Pediatric interactive screening
tool adapts to institutional needs
Physicians from Omaha’s institutional-level branding and
Children’s Hospital and Medical adjustment of content to fit the
Center have developed a local context.
pediatric-specific COVID-19
screener. This application can Commercial applications
be accessed by a one-time include user data analytics
download as an offline app or and observation, branding and
directly on the web. delivery of content to target
populations, use in public
This tool can be used by a health, and dissemination or
variety of clinical and non- implementation of projects to
clinical end-users to access improve healthcare processes
information step-by-step. The or outcomes. The combination
software also provides tracking of customizable content, user
to connect user behavior with analytics, and interactive
access of tagged content within surveys combines multiple
the tool. The customization distinct features into a single
nature of the tool allows for software tool.
Rundown
n COVID-19 screener specifically
for pediatric patients
n Available as a web-based or
native app
n Allows for institutional-level
branding
INVENTORS
n Ellen Kerns
n Russell McCulloh
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
31
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
COVID-19
COVID-19 Screener
Infectious Diseases
Rapidly screen patients for COVID-19
Clinicians at the University of for other disease states. For
Nebraska Medical Center’s example, this tool could help
Department of Emergency a patient decide if they have a
Medicine have developed a simple case of a sore throat or
patient-focused screening a case of streptococcus. The
platform that allows patients screener then suggests if the
to engage with a screening patient should see a doctor
algorithm that can calculate the or reach for over-the-counter
patient’s risk and probability care based on the severity of
of a COVID-19 diagnosis. This symptoms. This screener, by
technology also provides the steering consumer’s decision
patient with recommendations making process, has the ability
that are specific to their unique to work with local pharmacies
scenario and set of symptoms. and increase foot traffic.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
32 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Two-part Face Shield
Infectious Diseases
New design
improves PPE adherence
Donning and doffing personal protective equipment can be
cumbersome, and carries with it the risk of potential exposure.
During the on-going COVID-19 pandemic, clinicians are expected
to have a face shield on at all times. They are expected to change
the face shield between each patient visit or in case of a shortage,
decontaminate the shield between visits.
Rundown
n User protected from exposure
to disease conditions
n Shield can be re-used under
shortage conditions
n Can be easily de-contaminated
INVENTORS
n Michael Wadman
n Thang Nguyen
n Wesley Zeger
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
33
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
COVID-19
GEMs for COVID-19
Infectious Diseases
Find answers with genetically
engineered mice for SARS-CoV-2
Mouse models could create opportunity for creating a
answers to several lingering versatile set of genetically
unanswered questions about engineered mouse models
the COVID-19 outbreak and the useful for COVID-19 and SARS-
virus that created it, SARS- CoV-2 research.
CoV-2. Geneneticlly engineered
mice will help scientists UNMC researcher,
understand the molecular Channabasaviah Gurumurthy,
mechanisms of the virus, PhD, has developed three
repurpose currently available broad categories of genetically
antiviral drugs, and provide an engineered mouse models,
opportunity to develop new and about 30 different model
therapies and vaccines against designs for SARS-CoV-2
COVID-19. One major challenge research:
in achieving these goals is 1. Knocking-in expression
the lack of suitable preclinical cassettes, or point
animal models. mutations, into the
endogenous mouse ACE2
Unfortunately, SARS-CoV-2 locus.
only infects mice if they express 2. Knocking-in CRE-
human ACE2. This feature, activatable- or tetracycline
combined with a wealth of inducible-hACE2
genetic tools available only expression cassettes into
in mice, offers a unique safe-harbor loci, by re-
engineering the existing
reporter or inducer lines.
Rundown 3. Knocking-in CRE-
n Preclinical mouse models activatable cassettes into
directed towards a variety of the mouse ACE2 locus.
members in the SARS-CoV-2
transmission process The natural non-permissiveness
n Models are generated under
of mice to SARS-CoV-2
different mouse backgrounds
n Research use only infection in combination with a
wide variety of available genetic
INVENTORS tools and molecular switches
n Channabasavaiah Gurumurthy offers a unique opportunity to
n Masato Ohtsukan make this species useful for
n Rolen Quadros COVID-19 research.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
34 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Nasopharyngeal Specimen Collection Device
Infectious Diseases
New collection kit simplifies,
improves virus testing accuracy
Clinicians at the University
of Nebraska Medical Center Rundown
have developed a self- n Alternative to traditional naso-
contained specimen container pharangeal swabs
n One-stop solution for gather-
that collects and preserves ing, storing and testing nasal
nasopharyngeal specimens for secretions
testing. n Prototype available for review
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
35
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
COVID-19
SARS-CoV-2 antigens & serological assay
Novel antigens could help
Infectious Diseases
detect, fight coronavirus
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
PAPR Adapter
Infectious Diseases
3D print file creates adapter for
previously incompatible systems
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
37
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
COVID-19
3D-Printed Nasal Swabs
Overcome shortages with
Infectious Diseases
additive manufacturing
developed a new
solution to chronic
shortages caused
by the COVID-19
pandemic. In
particular, the
inventors created a
new type of nasal
swab that can be
used to collect patient
samples for testing
various contagions,
including the novel
coronavirus.
The nasopharyngeal
swab can be rapidly
produced at a relatively low-
cost using a filament-based Rundown
3D-printer.The swabs are also n Cost-effect solution to pan-
demic-related shortages
printed in such a way that n Clinical testing proves 3D
gives the swab a reliable tensile swabs just as effective as
strength that reduces the chance cotton
of it breaking during a procedure. n Print files available upon
request
Currently in use at Nebraska n Licensing opportunities for
Medicine, UNMC’s clinical more advanced version also
partner, the swabs were printed available
using polyethylene terephthalate
INVENTOR
glycol filament, a food- n Jesse Cox
grade plastic that is relatively
inexpensive and widely available.
Further, PETG is a thermoplastic polyester that is durable,
chemically inert and well suited for structural applications.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
38 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Infectious aerosol filter housing
Reusable housing
Infectious Diseases
allows replacement filters
Virus filters are commonly
used to prevent patients from
dispersing virus-containing
droplets when receiving oxygen
therapy, or during intubation
procedures that use ventilators
to help the patients breathe.
But during a pandemic like the
COVID-19 outbreak, supplies of
the typically disposable single-
use filters become scarce.
Rundown
n Overcomes filter scarcity during
pandemics like COVID-19
n Can be cleaned and reused
n Can accommodate any tubing
system
n Several sizes and shapes are
also available
INVENTORS
n Greg Pugh
n James Linder
n Max Kaeter
n Nicholas Markin
n Steven Lisco
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
39
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
Infectious Aerosol Capture Mask COVID-19
Infectious Diseases
caregivers from viral exposure
A new protective device can “catching more than 90 percent of
help protect healthcare workers airborne particles expelled in the
everywhere, preventing infected mask, ultimately preventing the
patients from spraying or exhaling aerosol from entering the patient
viral agents and potentially environment.” He added: “Even
infecting others in the room. when the vacuum wasn’t turned
on, the mask was still 85 percent
Aerosol capture maskDeveloped effective as a barrier.”
by the chair of UNMC’s
Department of Anesthesiology, At this initial stage, the special
Steven Lisco, M.D., the Infectious adapter for the Infectious Aerosol
Aerosol Capture Mask is a face Capture Mask is available
tent that covers the patient’s for purchase through Omaha
mouth and nose, and is then Custom Manufacturing at info@
coupled with a viral filter and a omahacustommfg.com or 800-
special adapter that connects the 228-5021. All other components
unit to standard vacuum supplies are commonly accessible in
in most clinical settings. most clinical settings and readily
found through various medical
The Nebraska Medicine Innovation equipment suppliers.
Committee has approved the
device for use in its facilities, and A future version of the technology
has already deployed them in will incorporate all components
operating rooms and elsewhere in into one contiguous device,
the hospital. but that will not be available for
purchase until later this year.
Hospitals risk wider contamination
from COVID-19 patients when they
cough or even just breathe. They Rundown
produce microscopic particles that n Limits caregiver exposure to
float through the air of their rooms, aerosolized viral agents
and potentially beyond. Even n Covers the patient’s mouth and
patients that have no symptoms nose
may still unwittingly spread the n Assembled from commonly
virus in the same way, particularly available products in clinical
when wearing supplemental settings
oxygen or undergoing the n Universal adapter connects to
procedures that insert or remove standard vacuum line found in
breathing tubes. most clinical settings
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
40 TECHNOLOGY
2020
University of Nebraska Medical Center
INFECTIOUS DISEASES PORTFOLIO
COVID-19
Vaccine Platform
New strategy to prevent viral
Infectious Diseases
infections, including coronavirus
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
41
2020
University of Nebraska Medical Center
PORTFOLIO INFECTIOUS DISEASES
COVID-19
Intubation Shield
Protect providers from COVID-19
Infectious Diseases
In response to
the COVID-19
pandemic, a
new intubation
box developed
at the University
of Nebraska
Medical Center,
helps protect
healthcare
workers by
shielding them
from exposure
to various
contagions and
contaminants*.
Contact:
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
43
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
COVID-19
Intubation Shield
Protect providers from COVID-19
Medical Devices
In response to
the COVID-19
pandemic, a
new intubation
box developed
at the University
of Nebraska
Medical Center,
helps protect
healthcare
workers by
shielding them
from exposure
to various
contagions and
contaminants*.
Contact:
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
COVID-19
Infectious aerosol filter housing
Reusable housing
Medical Devices
allows replacement filters
Virus filters are commonly
used to prevent patients from
dispersing virus-containing
droplets when receiving oxygen
therapy, or during intubation
procedures that use ventilators
to help the patients breathe.
But during a pandemic like the
COVID-19 outbreak, supplies of
the typically disposable single-
use filters become scarce.
Rundown
n Overcomes filter scarcity during
pandemics like COVID-19
n Can be cleaned and reused
n Can accommodate any tubing
system
n Several sizes and shapes are
also available
INVENTORS
n Greg Pugh
n James Linder
n Max Kaeter
n Nicholas Markin
n Steven Lisco
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
45
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Infectious Aerosol Capture Mask COVID-19
Medical Devices
caregivers from viral exposure
A new protective device can “catching more than 90 percent of
help protect healthcare workers airborne particles expelled in the
everywhere, preventing infected mask, ultimately preventing the
patients from spraying or exhaling aerosol from entering the patient
viral agents and potentially environment.” He added: “Even
infecting others in the room. when the vacuum wasn’t turned
on, the mask was still 85 percent
Aerosol capture maskDeveloped effective as a barrier.”
by the chair of UNMC’s
Department of Anesthesiology, At this initial stage, the special
Steven Lisco, M.D., the Infectious adapter for the Infectious Aerosol
Aerosol Capture Mask is a face Capture Mask is available
tent that covers the patient’s for purchase through Omaha
mouth and nose, and is then Custom Manufacturing at info@
coupled with a viral filter and a omahacustommfg.com or 800-
special adapter that connects the 228-5021. All other components
unit to standard vacuum supplies are commonly accessible in
in most clinical settings. most clinical settings and readily
found through various medical
The Nebraska Medicine Innovation equipment suppliers.
Committee has approved the
device for use in its facilities, and A future version of the technology
has already deployed them in will incorporate all components
operating rooms and elsewhere in into one contiguous device,
the hospital. but that will not be available for
purchase until later this year.
Hospitals risk wider contamination
from COVID-19 patients when they
cough or even just breathe. They Rundown
produce microscopic particles that n Limits caregiver exposure to
float through the air of their rooms, aerosolized viral agents
and potentially beyond. Even n Covers the patient’s mouth and
patients that have no symptoms nose
may still unwittingly spread the n Assembled from commonly
virus in the same way, particularly available products in clinical
when wearing supplemental settings
oxygen or undergoing the n Universal adapter connects to
procedures that insert or remove standard vacuum line found in
breathing tubes. most clinical settings
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
46 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
COVID-19
Nasopharyngeal Specimen Collection Device
New collection kit simplifies,
Medical Devices
improves virus testing accuracy
Clinicians at the University
of Nebraska Medical Center Rundown
have developed a self- n Alternative to traditional naso-
contained specimen container pharangeal swabs
n One-stop solution for gather-
that collects and preserves ing, storing and testing nasal
nasopharyngeal specimens for secretions
testing. n Prototype available for review
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
47
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
COVID-19
3D-Printed Nasal Swabs
Overcome shortages with
Medical Devices
additive manufacturing
developed a new
solution to chronic
shortages caused
by the COVID-19
pandemic. In
particular, the
inventors created a
new type of nasal
swab that can be
used to collect patient
samples for testing
various contagions,
including the novel
coronavirus.
The nasopharyngeal
swab can be rapidly
produced at a relatively low-
cost using a filament-based Rundown
3D-printer.The swabs are also n Cost-effect solution to pan-
demic-related shortages
printed in such a way that n Clinical testing proves 3D
gives the swab a reliable tensile swabs just as effective as
strength that reduces the chance cotton
of it breaking during a procedure. n Print files available upon
request
Currently in use at Nebraska n Licensing opportunities for
Medicine, UNMC’s clinical more advanced version also
partner, the swabs were printed available
using polyethylene terephthalate
INVENTOR
glycol filament, a food- n Jesse Cox
grade plastic that is relatively
inexpensive and widely available.
Further, PETG is a thermoplastic polyester that is durable,
chemically inert and well suited for structural applications.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
48 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
COVID-19
Two-part Face Shield
New design
Medical Devices
improves PPE adherence
Donning and doffing personal protective equipment can be
cumbersome, and carries with it the risk of potential exposure.
During the on-going COVID-19 pandemic, clinicians are expected
to have a face shield on at all times. They are expected to change
the face shield between each patient visit or in case of a shortage,
decontaminate the shield between visits.
Rundown
n User protected from exposure
to disease conditions
n Shield can be re-used under
shortage conditions
n Can be easily de-contaminated
INVENTORS
n Michael Wadman
n Thang Nguyen
n Wesley Zeger
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
49
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
COVID-19
PAPR Adapter
3D print file creates adapter for
Medical Devices
previously incompatible systems
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
50 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
COVID-19
Hand guard slit lamp shield
New guard protects
Medical Devices
opthamologists’ hands
New guard protects opthamologists’ hands
during exams Rundown
n Protects
opthamologists’
An opthalmologist from the University of
hands during an
Nebraska Medical Center has developed a optometric exam
slit lamp shield that can protect the patient n Easy to remove,
and examiner from respiratory droplets clean between
during an opthalmic or optometric exam. patients
This new design of the slit lamp shield
provides excellent coverage of the examiners INVENTOR
hands while retaining its universal use. n Rao Chundry
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
51
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Z-filter Device COVID-19
Medical Devices
particles during treatments
Clinicians from the University of
Nebraska Medical Center have
developed the Z-filter, a device
that mitigates the release of
infectious aerosolized particles
during nebulizing treatments.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
53
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Intubation Shield
Protect providers from
Medical Devices
COVID-19 outbreak
In response to the COVID-19 Bulk orders of five or more are
pandemic, a new intubation box $100 each. Prices do not include
developed at the University of shipping.
Nebraska Medical Center, helps
protect healthcare workers by Learn more at https://www.
shielding them from exposure unemed.com/product/intubation-
to various contagions and box.
contaminants*.
*Note: These statements have not
The lightweight material stores flat been evaluated by the Food and Drug
and can be assembled in seconds. Administration. These products are not
intended to diagnose, treat, cure or
It fits around the patient’s head prevent any disease.
and neck area while providing a
care provider with enough space
and access to safely perform Rundown
intubation procedures. n Lightweight, assembles in sec-
onds
The UNMC Intubation Shield n Clear plastic lies flat when not in
is available for purchase, with use
special discounts available for n Can be sanitized for multiple uses
bulk purchases. Prices are steeply
discounted due to the obvious Care instructions
need. Regular price was $300, n Clean the surface using a
but indivdual units will be sold at 100% cotton cloth and soapy
$150 until the pandemic subsides. water. Rinse with clean water.
n UV light, alcohol or a mild
bleach and water solution can
also be used.
n Do not use Windex or clean-
ers with petroleum products
listed in the ingredients. They
may cause the polycarbonate
to weaken and crack.
To Order
n Email Cori Harsh at charsh@
unmc.edu
n Cost is $150 plus shipping
for one. Bulk orders of five or
more are $100 per shield, plus
shipping. Will be shipped from
Omaha, Nebraska.
Contact:
2020
University of Nebraska at Omaha
MEDICAL DEVICES PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
55
2020
University of Nebraska at Omaha
PORTFOLIO MEDICAL DEVICES
Hybrid arm
One device combines best of body-
Medical Devices
powered, motor-driven prostheses
A new cyborg
prosthetic arm design
brings prosthetics
one step closer to
replicating anatomy.
Traditional
electronically-powered
prostheses have two
common downfalls:
weight and a lack of
manual, body-powered
control.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
56 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
57
2020
University of Nebraska at Omaha
PORTFOLIO MEDICAL DEVICES
Modular prosthetic arm
Prosthetics adapts to lifestyle
Medical Devices
A modular prosthetic arm, invented at UNO Biomechanics, is body-
powered, lightweight and made to accommodate a smorgasbord
of task-specific end-effector attachments. The end-effectors are
specially engineered to perform specific, challenging tasks such
as playing a stringed instrument, swimming, riding a bike, and
participating in team sports like basketball and baseball.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
58 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Rundown
n Highly customizable scaffold
for bone tissue regeneration
n May be formulated with addi-
tional therapeutics for targeted
therapy
n Biodegradable
INVENTORS
n Jingwei Xie
n Sunil Kumar Boda
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
59
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Medical Devices
sacrifice precision for comfort
A new head
strap for
surgical
magnifying
eyeglasses—
or surgical
loupes—will
relieve strain
and fatigue
for surgeons,
clearing the
way for more
accurate
and efficient
procedures.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
61
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Medical Devices
Distal radius fracture plating system
Universal plating system
saves time, improves outcomes
Wrist fractures don’t come in
one shape and size, but a new
fixation device just might. A leading
orthopedic surgeon at the University
of Nebraska Medical Center, Daniel
Firestone, M.D., invented a universal
wrist fracture fixation plate. By Rundown
studying fragment-specific plating n Universal plate for distal
systems, Dr. Firestone designed a radius fractures
novel plate that blends the essential n Benefit of optimal
components of each. The result is an fragment fixation systems
elegant system with enough flexibility n Benefit of surgeon comfort
to secure any of the most common with the procedure
wrist fracture patterns. n Replaces, combines
several plating systems
The Firestone Plating System is into one
a next-generation technology INVENTOR
that provides all of the benefits of n Daniel Firestone, M.D.
fragment specific plating without
the drawbacks associated with
surgically placing multiple devices. It
singlehandedly addresses a number
of fractures in both dorsal and volar
fragments. It’s is easy to use and
easier to install, potentially increasing
operating room and surgical
efficiency.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
MedLens
Upgrade any smartphone
Medical Devices
into a diagnostic tool
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
63
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Endovascular training
New manikin improves training
Medical Devices
for endovascular procedures
Researchers at
the University of
Nebraska Medical
Center developed
a simulation
manikin for vascular
procedures to
help physicians,
residents, and
medical students
improve skills and
test medical devices.
The simulation
manikin replicates
the vascular system,
including special
valves for controlled
bleeding and a life-like pulse. The vascular system can be swapped
out so users can practice on various anatomies such as healthy
vascular systems with specific diseases or disorders—aortic
dissections, aortic aneurysms and plaques.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
64 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
65
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Medical Devices
in renal denervation procedures
Researchers at UNMC developed a
device capable of making high blood Rundown
n Detects small changes
pressure more treatable by accurately
n Measures success of
measuring the rhythmic constriction renal denervation
and relaxation of blood vessels, known n Increase success rate
as sympathetic vasomotion. n Can screen for blood
pressure-related fainting
The sympathetic nervous system n non-invasive
controls the body’s automated hemodynamic
functions such as digestion, heart rate monitoring
and the vasomotion of blood vessels.
Disruption of the sympathetic nervous INVENTORS
n Irving Zucker, Ph.D.
system can contribute to a variety of
n Alicia Schiller
chronic diseases, including high blood n Peter Pellegrino
pressure.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Automated REBOA
New device to save patients
Medical Devices
from catastrophic bleeding
A new automated bleeding-control system that can reduce deaths
related to catastrophic internal bleeding has been developed at the
University of Nebraska Medical Center.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
67
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Medical Devices
Manage the airway of trauma patients
When emergency
staff are challenged
with a trauma patient
that needs to be
intubated, they must
act swiftly. If the
patient suffers from
abundant bleeding of
the mouth, aspiration,
or vomiting the
airway view could be
obstructed.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
68 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
69
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Medical Devices
New design improves bypass
success in lower extremities
Researchers at the University
of Nebraska Medical Center
developed a highly flexible
vascular bypass graft for the
treatment of peripheral artery
disease.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
71
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Tongue retractor
Intubating made easier
Medical Devices
Airway intubation, the
procedure where an inserted Rundown
n Inexpensive device specialized for
tube assists a patient to clearing the mouth and opening
breathe, can be complicated the jaw
by the patient’s anatomy, n Easy to manufacture as a durable
lack of mobility in the neck, or disposable device
and trauma in the mouth and n A perfect complement to camera
throat. assisted intubation
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
72 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
73
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Nanofiber microspheres
Enhance cell delivery
Medical Devices
for improved healing
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
74 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
Nanofiber rings
Implant, customize drug delivery device
Medical Devices
Researchers at the University
of Nebraska Medical
Center have developed
a new implantable drug
delivery device made out of
nanofibers.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
Medical Devices
Healthcare providers now have a better, more reliable way to
improve dialysis in patients with kidney failure.
An arteriovenous or AV fistula
is a point of entry and exit to Rundown
the blood vessels that also n First major improvement for the
allows large amounts of blood AV fistula in more than 40 years
to flow uninterrupted. This n Medical device that promotes
portal serves as a connection fistula maturation
between an artery and a vein in n Capable of maturing AV fistulas
the patient’s arm and allows the in an animal model
n Inexpensive, single use
vein to grow large and strong n Multiple applications beyond
providing reliable access to fistula maturation
blood vessels each time.
INVENTOR
AV fistulas are a complex and n Marius Florescu, M.D.
imperfect solution, even when
performed by an expert team of
surgeons and support staff.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
76 TECHNOLOGY
2020
University of Nebraska Medical Center
MEDICAL DEVICES PORTFOLIO
AquaBlade is an
innovative surgical
instrument that uses a catheter to deliver a specialized cutting tool
through a patient’s artery where it uses a high-pressure water jet to
repair life-threatening tears in artery walls. The device could also be
used to deploy custom-length stents in blood vessels or even help
remove previously deployed stents.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
77
2020
University of Nebraska Medical Center
PORTFOLIO MEDICAL DEVICES
Cardiac vascular access graft
Better care for children with heart defects
Medical Devices
Many babies born with congenital defects of the heart now live to
become adults. Pediatric congenital heart disease and the heart
defects that it produces used to be completely lethal. Surgery for
congenital heart defects can now correct the majority of these
heart defects in infants.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
79
2020
University of Nebraska Medical Center
PORTFOLIO METABOLIC
Metabolic
diagnoses earlier than ever before. n Simple blood test
A simple blood test developed n Helps predict immunotherapy
treatments
at the University of Nebraska n Flow cytometry based assay
Medical Center monitors certain to assess populations of
immune cell populations which T-cell subsets
can indicate changes in normal
physiology. INVENTORS
n Nora Sarvetnick, Ph.D.
This method may catch Type 1 n Robert Harms
diabetes earlier, which would
mean more therapeutic and
preventative options for patients and their physicians. This method
might also predict patient responses to immunological treatment
options.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
METABOLIC PORTFOLIO
Improve AV fistulas
Fistulas mature faster, better & safer
Healthcare providers now have a better, more reliable way to
improve dialysis in patients with kidney failure.
An arteriovenous or AV fistula
is a point of entry and exit to Rundown
the blood vessels that also n First major improvement for the
allows large amounts of blood AV fistula in more than 40 years
to flow uninterrupted. This n Medical device that promotes
portal serves as a connection fistula maturation
between an artery and a vein in n Capable of maturing AV fistulas
the patient’s arm and allows the in an animal model
n Inexpensive, single use
vein to grow large and strong n Multiple applications beyond
providing reliable access to fistula maturation
blood vessels each time.
INVENTOR
AV fistulas are a complex and n Marius Florescu, M.D.
imperfect solution, even when
performed by an expert team of
surgeons and support staff.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
82 TECHNOLOGY
2020
University of Nebraska at Omaha
MISCELLANEOUS PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
Nanofiber microspheres
Enhance cell delivery
Miscellaneous
for improved healing
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
84 TECHNOLOGY
2020
University of Nebraska at Omaha
MISCELLANEOUS PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
85
2020
University of Nebraska Medical Center
PORTFOLIO MISCELLANEOUS
Miscellaneous
doctors just-in-time training
Nick Markin, M.D., Director of
Perioperative Imaging at the University Rundown
of Nebraska Medical Center, invented n Anatomically accurate
custom medical procedures simulators. n Layered models: arti-
These anatomically accurate simulators ficial bone, tissue and
are made with artificial mimics of vasculature
n Echogenic
bone, tissue and vasculature. They n Critical vascular and
are echogenic and provide training for non-vascular access
multiple critical vascular access and procedures
non-vascular access procedures when
they are needed most. INVENTOR
n Nick Markin, M.D.
Anesthesiologists perform many
routine procedures, but occasionally
receive patients with extreme trauma that require immediate and
unique assistance. Due to the rarity of these events, it is difficult
for clinicians to receive this crucial training. To solve this training
gap, Dr. Markin developed a process for creating custom medical
procedure simulators that fit into the “just-in-time” educational
model. A “just-in-time” training platform is one that provides
educational tools and courses as they are needed, rather than
waiting for online courses or sporadic seminars.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
86 TECHNOLOGY
2020
University of Nebraska at Omaha
MISCELLANEOUS PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
87
2020
University of Nebraska at Omaha
PORTFOLIO MISCELLANEOUS
Self-Pacing treadmill
New treadmill adjusts to user’s pace
Miscellaneous
For the first time, a self-pacing
treadmill can now speed up and slow Rundown
down to match the pace of its user, n Dramatically improves
thanks to a team of scientists at the treadmill safety
University of Nebraska at Omaha. n Better simulates outdoor
running
The technological breakthrough n Requires only software
not only opens up a whole new and inexpensive sensors
range of opportunities in recovery
INVENTORS
and rehabilitation, but eliminates n Casey Wiens, Ph.D.
the danger of current treadmills n Molly Schieber, Ph.D.
throwing runners who misstep or fail n William Denton, Ph.D.
to keep pace. Some 24,000 go to
the emergency room each year with
treadmill related injuries.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
2020
University of Nebraska at Omaha
MISCELLANEOUS PORTFOLIO
Science education
needs to reach
out to everyone. Science, Technology, Engineering and Math,
STEM education, needs to do more to make scientists, engineers
and mathematicians as diverse as the people that rely on their
discoveries. Maurice Godfrey, Ph.D., produced science classroom
posters that promote laboratory safety rules. The classroom
posters depict students from diverse ethnic backgrounds. Each
one focuses on a different aspect of laboratory safety.
Contact:
Jason Nickla
jnickla@unmc.edu
402-559-8983
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
89
2020
University of Nebraska Medical Center
PORTFOLIO MISCELLANEOUS
PDE4B selective inhibitors
Improve treatments for
inflammatory diseases
Miscellaneous
A UNMC chemist has developed
new compounds for the treatment of Rundown
inflammatory diseases. n Selective for the B
isoform of PDE4
These compounds target a protein n Enhanced uptake into
called phosphodiesterase 4, or the CNS
PDE4 for short. PDE4 regulates n Nanomolar potency
inflammation, and is involved in a n Useful for treating a
number of inflammatory diseases such variety of inflammatory
diseases
as chronic obstructive pulmonary
disease, rheumatoid arthritis, psoriasis, INVENTOR
atopic dermatitis, inflammatory bowel n Corey Hopkins, Ph.D.
disease, and central nervous system
diseases that include drug addiction,
schizophrenia and neurodegenerative
diseases.
Several approved drugs currently target PDE4, but with severe side
effects—like nausea and vomiting—that limit their use. Many of the
current PDE4 inhibitors have poor uptake into the central nervous
system which limits their use in the treatment of central nervous
system diseases.
The new PDE4 inhibitors are designed for increased uptake into
the central nervous system, making them more useful than current
drugs for treating central nervous system-related inflammatory
diseases.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
90 TECHNOLOGY
2020
University of Nebraska at Omaha
MISCELLANEOUS PORTFOLIO
Hybrid arm
One device combines best of body-
powered, motor-driven prostheses
Miscellaneous
A new cyborg
prosthetic arm design
brings prosthetics
one step closer to
replicating anatomy.
Traditional
electronically-powered
prostheses have two
common downfalls:
weight and a lack of
manual, body-powered
control.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
92 TECHNOLOGY
2020
University of Nebraska Medical Center
NEUROLOGIC PORTFOLIO
Parkinson’s Disease
New method allows for early diagnosis
A new discovery at the
University of Nebraska
Medical Center could take
most of the guesswork out
of delivering an accurate
Neurologic
and reliable diagnosis for
Parkinson’s disease.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
93
2020
University of Nebraska Medical Center
PORTFOLIO NEUROLOGIC
Parkinson’s Disease
Vaccine may signal beginning
of end to Parkinson’s disease
A novel combination developed by researchers at the University
of Nebraska Medical Center may be the final solution that could
Neurologic
deliver a knockout blow to Parkinson’s disease.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
TECHNOLOGY
95
2020
University of Nebraska Medical Center
PORTFOLIO RESEARCH TOOLS
COVID-19
GEMs for COVID-19
Find answers with genetically
Research Tools
engineered mice for SARS-CoV-2
Mouse models could create opportunity for creating a
answers to several lingering versatile set of genetically
unanswered questions about engineered mouse models
the COVID-19 outbreak and the useful for COVID-19 and SARS-
virus that created it, SARS- CoV-2 research.
CoV-2. Geneneticlly engineered
mice will help scientists UNMC researcher,
understand the molecular Channabasaviah Gurumurthy,
mechanisms of the virus, PhD, has developed three
repurpose currently available broad categories of genetically
antiviral drugs, and provide an engineered mouse models,
opportunity to develop new and about 30 different model
therapies and vaccines against designs for SARS-CoV-2
COVID-19. One major challenge research:
in achieving these goals is 1. Knocking-in expression
the lack of suitable preclinical cassettes, or point
animal models. mutations, into the
endogenous mouse ACE2
Unfortunately, SARS-CoV-2 locus.
only infects mice if they express 2. Knocking-in CRE-
human ACE2. This feature, activatable- or tetracycline
combined with a wealth of inducible-hACE2
genetic tools available only expression cassettes into
in mice, offers a unique safe-harbor loci, by re-
engineering the existing
reporter or inducer lines.
Rundown 3. Knocking-in CRE-
n Preclinical mouse models activatable cassettes into
directed towards a variety of the mouse ACE2 locus.
members in the SARS-CoV-2
transmission process The natural non-permissiveness
n Models are generated under
of mice to SARS-CoV-2
different mouse backgrounds
n Research use only infection in combination with a
wide variety of available genetic
INVENTORS tools and molecular switches
n Channabasavaiah Gurumurthy offers a unique opportunity to
n Masato Ohtsukan make this species useful for
n Rolen Quadros COVID-19 research.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
96 TECHNOLOGY
2020
University of Nebraska Medical Center
RESEARCH TOOLS PORTFOLIO
This cell line is a promising tool that will help further elucidate the
mechanisms of ethanol-induced hepatocellular injury.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
97
2020
University of Nebraska Medical Center
PORTFOLIO RESEARCH TOOLS
Research Tools
via Oviductal Nucleic Acids Delivery
Directly edit zygote genes
The i-GONAD method delivers – requiring a high level of
genome editing molecules, expertise, expensive and time-
directly to E0.7 embryos in consuming.
the oviducts of mice, via in
situ electroporation. This The i-GONAD technique relives
technique generates mouse these steps by delivering
models that can contain single genome editing nucleic acids
base changes, kilobase sized and CRISPR components into
deletions and knock-ins. embryos in situ. The process
i-GONAD treated females retain involves the exposure of the
reproductive function and are ovaries and oviduct of pregnant
useful for generating germlines mice bearing E0.7 embryos.
in future generations. The genome editing reagents
are injected into the oviductal
The University of Nebraska lumen and the entire oviduct
Medical Center’s is subjected to electroporation
Channabasavaiah Gurumurthy, using tweezer-type electrodes.
Ph.D., collaborated with These in situ, genome edited
Japanese researchers embryos are allowed to develop
Masato Ohtsuka, Ph.D., to term and genotyped for the
and Hiromi Miura, Ph.D., of targeted mutation.
Tokai University’s School of
Medicine, invented i-GONAD This technique, when used in
. Traditionally, generating combination with Easi-CRISPR,
transgenic mouse-models another invention from Dr.
involves three critical steps: Gurumurthy and Dr. Ohtsuka,
isolation of zygotes from inserts long single stranded
sacrificed females, zygote DNA donor format with insertion
micromanipulation ex vivo efficiency as high as 100%.
and transfer of these modified This combination changes the
zygotes into another set of landscape of transgenic animal-
female mice. This process has model generation and provides
remained unchanged for over a tool that is easy-to-perform
four decades and is laborious and has high efficiency.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
2020
University of Nebraska Medical Center
RESEARCH TOOLS PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
99
2020
University of Nebraska Medical Center
PORTFOLIO RESEARCH TOOLS
Research Tools
drugs for heart disease
A team of scientists
at UNMC invented a
milestone between the
petri dish and animal
tests, which could save
the drug development
industry untold millions
in research and
development. Using
a known technique
called co-culture, the
scientists invented a
highly efficient way to
create artificial arteries
that could reduce the Gap junction between the endothelial cells (arrow heads)
cost of drug discovery. were identified under scanning electron microscope.
Monocytes bond to endothelial cells at gap junction area
(white arrows). Monocyte migrated into and underneath the
In the complex and endothelial cell layer (red arrow).
expensive realm of
drug discovery, scientists screen drugs
in a series of increasingly expensive Better drugs for
experiments. One of the earliest jumps in heart disease
expense is going from testing drugs on n Low cost, easy to
cells in a petri dish to testing the drugs in produce co-culture
living animals. Frequently, drugs that work model
in the petri dish eventually fail in animals. n Accurately models
artery physiology
But now, UNMC’s inventors can create n Inexpensively simu-
a simulated artery that models the lates atherosclerotic
disease
progression of coronary artery disease.
The model can test new drugs that slow INVENTORS
or reverse the progression of the leading n Ioannis Chatzizisis,
cause of death in the United States, M.D., Ph.D.
coronary artery disease. n Xiang-De Liu, M.D.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
2020
University of Nebraska at Omaha
RESEARCH TOOLS PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
101
2020
University of Nebraska Medical Center
PORTFOLIO RESEARCH TOOLS
Abdominal access viewport
Custom viewport reveals
Research Tools
organs, delivers medication
A novel abdominal window enables researchers to view functioning
tissue and organs of living animals. The surgically implanted
device is made from multiple biocompatible materials and highly
customizable.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
102 TECHNOLOGY
2020
University of Nebraska Medical Center
RESEARCH TOOLS PORTFOLIO
Easi-CRISPR
Increase DNA insertion
Research Tools
efficiency with Easi-CRISPR
CRISPR, the newest
gene editing technology,
efficiently slices DNA
unlike any other known
procedure. It’s a scientist’s
dream to delete mutated
or faulty DNA. But CRISPR
solves only half the
problem.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
Research Tools
study of autoimmune disorders
Casitas B cell
lymphoma-b (Cbl-b)
is a member of the
mammalian Cbl family
of proteins which are
characterized by an
N-terminal tyrosine
kinase binding domain,
linker domain, RING
finger domain, and a
variable C-terminal
domain. Cbl-b is an E3
ubiquitin ligase that is
critical for the proper
regulation of various
receptor tyrosine
kinases and non-receptor tyrosine kinases.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
104 TECHNOLOGY
2020
University of Nebraska Medical Center
RESEARCH TOOLS PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
Research Tools
tumor effects of therapeutic compounds
on MUC1-expressing pancreatic tumors
Pancreatic cancer is one
of the leading causes of
cancer related deaths.
Pancreatic cancer is
seldom detected at an
early stage, spreads
rapidly, and has poor
prognosis with less than
5% surviving over a
five-year time span. The
majority of all patients
with pancreatic cancer
have non-operable
disease and current
chemotherapies and radiotherapies are largely ineffective. As a
result, novel therapies that can effectively target pancreatic cancer
and help prevent metastasis are needed.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
2020
University of Nebraska Medical Center
RESEARCH TOOLS PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
107
2020
University of Nebraska Medical Center
PORTFOLIO RESEARCH TOOLS
NR-6-R cells
Cell line available for study of FGF activity
Research Tools
Fibroblast Growth
Factors (FGFs) and
fibroblast growth
factor receptors
together form a highly
conserved signaling
system that is used in
both developmental
and physiological
processes of the
adult. The 18 known
FGFs are involved
in the development
and homeostasis of
virtually every human
tissue. Given its
ubiquity, establishing
FGF activity is
a critical step in
understanding a wide
variety of biological
processes.
NR-6-R cells are a versatile and sensitive tool for determining FGF
activity and have been employed in a variety of assays. UNeMed
is currently offering licensing
opportunities for the NR-6-R
Rundown cells produced in Dr. Rizzino’s
n Research use only laboratory. The cells can be
n Non-exclusive licenses available employed in a wide variety
of assays, such as soft agar
INVENTOR assays and proliferation
n Angie Rizzino, Ph.D. assays, to identify and
measure FGF activity.
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
108 TECHNOLOGY
2020
University of Nebraska Medical Center
ANTIBODIES PORTFOLIO
Anti-Ajuba that join cells to one another.
Ajuba plays an important role in regulation Epitope: N-terminal region of Extracellular
of the kinase activity of AURKA/Aurora-A for domain 1 of desmoglein 2 and a region that is at
mitotic commitment. Ajuba is a component the fusion between EC1 and the proregion
Research Tools
of the IL-1 signaling pathway modulating IL-1- Species: Human
induced NF-κB activation and also plays a role Uses: WB, IF
in cadherin-mediated cell-cell adhesion and Type: Mouse mAb
influences cell migration. Publications: Keim S et al (2008) Hybridoma 27
Epitope: Human Ajuba (4) 249-258
Species: Human
Uses: WB, IF Anti-Desmoglein 2 (10D2)
Type: Mouse mAb Desmogleins are a family of cadherins that
Publications: None play a role in the formation of desmosomes
that join cells to one another.
Anti-ADA3 clone (5C9/C8) Epitope: C-terminal region of extracellular
Epitope: Human ADA3 domain 1 of desomglein 2
Species: Human Species: Human
Uses: WB, IHC Uses: WB, IP, IF
Type: Mouse mAb Type: Mouse mAb
Publications: Mohibi S et al. J. Biol Chem (2012) Publications: Keim S et al (2008) Hybridoma 27
v287: 29442-29456 ; Mirza et al. Breast Cancer Res (4) 249-258
Treat (2013) v137: 721-731; Mohibi S et al. J. Biol
Chem (2015) V290: 28299-28310 Anti-Desmoglein 2 (13B11)
Desmogleins are a family of cadherins that
Anti-Cadherin 11 (16A6) play a role in the formation of desmosomes
Cadherins are integral membrane proteins that join cells to one another.
that mediate calcium-dependent cell-cell Epitope: C-terminal region of extracellular
adhesion. domain 1 of desomglein 2
Epitope: EC domain Cad11 Species: Human
Species: Human Uses: WB, IP
Uses: WB,IP, IF Type: Mouse mAb
Type: Mouse mAb Publications: Keim S et al (2008) Hybridoma 27
Publications: None (4) 249-258
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
109
2020
University of Nebraska Medical Center
PORTFOLIO ANTIBODIES
Anti-DHHC13 (26D1) Anti-MUC4 (8G7)
DHHC13 is a member of the DHHC family Mucin-4 (MUC4) is a mucin protein and a
of palmitoyl-cyl transferases. These enzymes major constituent of mucus. MUC4 plays
catalyze the addition of palmitate onto various roles in the progression of cancer,
Research Tools
cysteine residues of target proteins. particularly due to its signaling and anti-
Epitope: Amino acids 40-150 adhesive properties which contribute to
Species: Human tumor development and metastasis. MUC4
Uses: WB, IF is also important in other diseases such
Type: Mouse mAb as endometriosis and inflammatory bowel
Publications: None disease.
Epitope: Tadem Repeat Domains
Anti-FGFR4 (19H3) Species: Human
Fibroblast growth factor receptor 4 (FGFR4), Uses: WB, IF, IHC
also known as CD334, is a member of the Type: mAb
fibroblast growth factor receptor family and Publications: Moniaux N et al (2004) J Histochem
a cell surface tyrosine kinase containing Cytochem 52 (2) 253-261
three immunoglobulin-like domains. FGFR4
is widely expressed in many tissues including Anti-NHERF-2 (32B6)
the intestine, muscle, heart, cornea, retina, and Sodium-hydrogen exchange regulatory
pancreas, with highest expression in lung and cofactor NHE-RF2 (NHERF-2) is also known
kidney. FGFR4 binds acidic fibroblast growth as tyrosine kinase activator protein 1 (TKA-1)
factor and ligand binding induces mitogenesis or SRY-interacting protein 1 (SIP-1). NHERF-2
and differentiation. FGFR4 is overexpressed in acts as a scaffold protein connecting plasma
gynecological tumor samples, suggesting a membrane proteins with members of the
role in breast and ovarian tumorigenesis. ezrin/moesin/radixin family, linking them to
Epitope: Human FGFR4 the actin cytoskeleton and regulating their
Species: Human surface expression.
Uses: WB, IP, IF Epitope: AA 149-231
Type: Mouse mAb Species: Human
Publications: None Uses: WB, IP, IF
Type: Mouse mAb
Anti-LGR6 (20E3) Publications: Theisen C et al (2007) Mol Biol Cell
LGR6 is a glycoprotein hormone receptor 18 (4) 1220-1232
that is a member of the leucine-rich repeat-
containing subgroup of the G protein-coupled Anti-OTK18
7-transmembrane protein superfamily. OTK18 is classified as a transcription
Epitope: Human LGR6 factor as it contains 13 C2H2-type DNA
Species: Human binding zinc finger motifs. C2H2 zinc finger
Uses: WB motifs are capable of binding to a wide
Type: Mouse mAb range of DNA sequences, including the HIV-
Publications: None 1 LTR. This human immunodeficiency virus
(HIV)-inducible zinc-finger protein reduces
Anti-MastL progeny-virion production in infected human
Microtubule-associated serine/thre- macrophages.
onine-protein kinase-like (MastL) has been as- Epitope: OTK 1-178
sociated with thrombocytopenia and throm- Species: Human
bocytopenia 2. MastL is a serine/threonine Uses: ELISA, WB, IHC
kinase that plays a key role in M phase by act- Type: mAb
ing as a regulator of mitosis entry and mmain- Publications: Buescher J et al (2008) J
tenance. Following DNA damage, MastL is Neuroimmune Pharmacol 3 (4) 230-235
also involved in checkpoint recovery by being
inhibited. May be involved in megakaryocyte
differentiation.
Epitope: C-terminus
Species: Human
Uses: WB, IHC
Type: Mouse mAb
Publications: None
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
110 TECHNOLOGY
2020
University of Nebraska Medical Center
ANTIBODIES PORTFOLIO
Contact:
Matt Boehm
mboehm@unmc.edu
402-559-2166
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
112 TECHNOLOGY
2020
University of Nebraska Medical Center
SOFTWARE PORTFOLIO
COVID-19
Modular Electronic Decision Support Builder
Pediatric interactive screening
tool adapts to institutional needs
Physicians from Omaha’s institutional-level branding and
Children’s Hospital and Medical adjustment of content to fit the
Center have developed a local context.
pediatric-specific COVID-19
Software
Rundown
n COVID-19 screener specifically
for pediatric patients
n Available as a web-based or
native app
n Allows for institutional-level
branding
INVENTORS
n Ellen Kerns
n Russell McCulloh
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
113
2020
University of Nebraska Medical Center
PORTFOLIO SOFTWARE
COVID-19
COVID-19 Screener
Rapidly screen patients for COVID-19
Clinicians at the University of for other disease states. For
Nebraska Medical Center’s example, this tool could help
Department of Emergency a patient decide if they have a
Medicine have developed a simple case of a sore throat or
patient-focused screening a case of streptococcus. The
platform that allows patients screener then suggests if the
Software
to engage with a screening patient should see a doctor
algorithm that can calculate the or reach for over-the-counter
patient’s risk and probability care based on the severity of
of a COVID-19 diagnosis. This symptoms. This screener, by
technology also provides the steering consumer’s decision
patient with recommendations making process, has the ability
that are specific to their unique to work with local pharmacies
scenario and set of symptoms. and increase foot traffic.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
114 TECHNOLOGY
2020
University of Nebraska Medical Center
SOFTWARE PORTFOLIO
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
115
2020
University of Nebraska Medical Center
PORTFOLIO SOFTWARE
Patient management, charting
Software improves CPR, keeps
complete record during codes
UNMC’s newest patient management application streamlines medical
complexity and simplifies decision support into a simple blueprint
that standardizes care for all patients regardless of circumstance,
stress, training and experience.
Software
It’s rare when a patient’s heart
stops or codes, but when they Rundown
do doctors and nurses must have n Get it right all the time
current guidelines at the ready. It’s a n Standardize care every-
complex, high-stress scenario where where
any number of things can go wrong. n Eliminates need to recall
A seemingly simple error can be the forgotten protocols
difference between life and death. n Easy and dynamic charting
real-time
Emergency medicine physician n Keep track of medications
Michael Wadman and nurse and doses
practitioner Thang Nguyen joined n Review past interventions
forces to create a catch-all solution:
A web-based application that helps INVENTORS
physicians and nurses in real-time n Michael Wadman, M.D.
analyze patients, obtain guidelines, n Thang Nguyen, A.P.R.N.
and document the course of care. n Trong Nguyen
With this system at their side, doctors can fully focus on improving
the survival and outcome of code patients.
Contact:
Catherine Murari-Kanti
catherine.murari@unmc.edu
402-559-3265
2020
University of Nebraska Medical Center
SOFTWARE PORTFOLIO
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
Software
weakness and even prior falling in minutes
n Fall risk can be assessed with 90
hospitalization.
percent specificity
A special insole and a INVENTOR
proprietary algorithm could n Arash Gonabadi, Ph.D.
help physicians more n Max Kurz, Ph.D.
accurately predict the n Nicholas Stergiou, Ph.D.
likelihood of falling, and n Philippe Malcolm, Ph.D.
help prevent serious injuries
to elderly patients in particular.
Contact:
Tyler Scherr
tyler.scherr@unmc.edu
402-559-2140
2020
University of Nebraska Medical Center
SOFTWARE PORTFOLIO
Contact:
Steve Schreiner
sjschreiner@unmc.edu
402-559-2176
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
119
2020
University of Nebraska Medical Center
PORTFOLIO SOFTWARE
Software
listening to music with a variable beat: chaotic music.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
120 TECHNOLOGY
2020
University of Nebraska Medical Center
SOFTWARE PORTFOLIO
Laparoscopic simulator
Affordable simulator helps train doctors faster
Surgical training is facing a crisis. Restrictions on resident work
hours have put new pressures on surgical residency: how do you
train new surgeons on fewer residency hours?
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
2020
University of Nebraska
TECHNOLOGY PORTFOLIO
cancer PORTFOLIO
cardiovascular
drug delivery
infectious diseases
medical devices
metabolic
miscellaneous
neurologic
research tools
software
startups
122 TECHNOLOGY
2020
University of Nebraska
STARTUPS PORTFOLIO
AcademicEdgar+
Burch Kealey, Ph.D., developed and licensed software to make EDGAR searches more efficient. Dr.
Kealey, an accounting associate professor of at the University of Nebraska at Omaha, developed the
program as a way to solve frustrations he encountered during a large research project.
Avert
Startups
An early product of the Omaha startup scene and the Biomechanics Department at the University
of Nebraska Omaha, Avert is building a non-invasive concussion detection system combining
biomechanics, artificial intelligence and cloud computing. The result is highly accurate, low-cost
device that can reliably determine when a person receives a concussion and when they recover.
BehaviorApp, LLC
UNMC psychology and pediatrics professor Keith Allen, Ph.D., partnered with Lincoln-based app
developer, SectorNow, on an application that helps parents communicate with autistic children.
Based on Dr. Allen’s research and naturalistic teaching method, the app was pushed through
development through his startup company, BehaviorApp. Called MySocius, the app is available
through the iTunes App Store.
Breezmed
Breezmed is a health informatics startup developing a new platform to ease workflow around
prior authorizations. Breezmed streamlines the different documents insurance companies often
require, making it easier for patients to get their prescriptions.
Calidum, Inc.
Calidum Inc, was formed around an innovative approach for simultaneously treating and
diagnosing some of the deadliest cancers. Janina Baranowska-Kortylewicz, Ph.D., a professor and
radiochemist at UNMC, developed “theranostic” compounds tagged with a radioactive isotope that
will help clinicians better diagnose, track and treat various cancers that include prostate, ovarian,
and triple negative breast cancer. The compounds could also be used on two rare forms of brain
tumors, neuroblastoma and glioblastoma.
Contact:
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
986099 Nebraska Medical Center Nebraska Medical Center and the University of Nebraska at Omaha, serving
Omaha, NE 68198-6099 researchers, faculty and staff who develop new technologies and inventions.
www.unemed.com UNeMed strives to help bring those innovations to the marketplace.
TECHNOLOGY
123
2020
University of Nebraska
PORTFOLIO STARTUPS
LabPoint
Originally created as a software company that solely provided services for UNMC and the state
public health lab. LabPoint has since expanded to offer services to the wider marketplace with
further development of their cornerstone product, ELIRT. Aimed at the healthcare industry, ELIRT
is a cloud-based software package that helps streamline the lab ordering process and improves
lab reporting.
Prommune Inc.
Late UNMC researcher Sam Sanderson, Ph.D., founded Prommune to develop his innovation, EP-
67, a protein formulation that can serve as a platform to activate and enhance the natural immune
system for a number of conditions. Prommune is currently focused on using EP-67 to deliver a
more effective vaccine for the H1N1 virus in pigs. In the future, Prommune hopes to expand to other
conditions and perhaps human use.
Startups
ProTransit NanoTherapy
Co-founded by former Entrepreneur-In-Residence, Gary Madsen, Ph.D., ProTransit Nanotherapy
is based on the work of former UNMC researcher Vinod Labshetwar, Ph.D., who is also a co-
founder in the Omaha-based startup. ProTransit is developing a nanoparticle as a delivery vehicle
for antioxidant enzymes to the deepest layers of the skin. The final product could be a topical
application such as skin cream or sun lotion that better protects the skin against cancer, blemishes
and wrinkles. There is also potential for additional applications that include treatment for some
spinal cord injuries or certain types of brain damage.
Vireo Resources
Nebraska manufacturing startup Vireo Systems was established in Plattsmouth, Neb., about 20
miles south of Omaha. Vireo manufactures popular muscle-building health supplements that were
developed at UNMC, Creatine Ethyl Ester and Creatine HCL. Vireo eventually outgrew its first facility,
expanding into a larger space in 2012. More than 20 Nebraskans are employed at Vireo, which holds
more than 40 manufacturing contracts.
Joe Runge
hrunge@unmc.edu
402-559-1181
UNeMed Corporation is the technology transfer office for the University of
Nebraska Medical Center and the University of Nebraska at Omaha, serving 986099 Nebraska Medical Center
researchers, faculty and staff who develop new technologies and inventions. Omaha, NE 68198-6099
UNeMed strives to help bring those innovations to the marketplace. www.unemed.com
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TECHNOLOGY
2020 PORTFOLIO
402-559-2468
unemed@unmc.edu
http://www.unemed.com
Mail:
986099 Nebraska Medical Center
Omaha, Nebraska 68198-6099
Location:
4460 Farnam St., Ste. 3000
Omaha, Nebraska 68198-6099
It is the policy of the University of Nebraska not to discriminate based upon age, race, ethnicity, color, national origin, gender, sex,
pregnancy, disability, sexual orientation, genetic information, veteran’s status, marital status, religion or political affiliation.