Annotated Bibliography Graphic Organizer

Effectiveness of Saltwater Baths in the Treatment of Epidermolysis Bullosa.- Petersen, Brian Woodford

Name: Betsy Frazier

Source #2 Hsu, Chao-Kai, et al. "Treatment Of Hereditary Epidermolysis

Bibliography Bullosa: Updates And Future Prospects." American Journal Of
(MLA) Clinical Dermatology 15.1 (2014): 1-6. Academic Search
Complete. Web. 22 Jan. 2017.
10 pts

Annotation: This source contains different experiments that have been

(Describe ALL info. that conducted into figuring out a cure or a better and more effective
might be important for treatment for sufferers of Epidermolysis Bullosa. The
your paper. Explain to the experimental treatments include: gene therapy, protein
reader and/or summarize replacement therapy, Intradermal Injection of Allogeneic
what might be found in Fibroblasts, Intradermal Injection of Mesenchymal Stromal Cells,
this source) Bone Marrow Stem Cell Therapy, Natural Gene Therapy:
Revertant Mosaicism, and Inducible Pluripotent Stem Cells. This
35 pts study elaborates on the effectiveness of the treatment and if it is
safe or if there were any difficulties with the treatment. Although
some of these treatments are more effective than others, it
highlights on the fact that there is still not a cure. It also mentions
that some of these treatments work better for some people than
others, it all depends on their genetic makeup and the severity of
their case.

some forms of EB require daily changes of wound

Potential Quotes:
(Are there any significant
quotes you can use or
paraphrase from this
source?)
15 pts
dressings that can take several hours to perform and
strenuous efforts are needed to maintain adequate mobility
and nutrition, and to limit complications such as skin
infection, scarring, dental caries, dysphagia, constipation,
and skin cancer. (page 1)
One study found no difference between fibroblasts
or vehicle in wound healing responses [21], but another
trial showed that a single injection of allogeneic fibroblasts
can accelerate wound healing in RDEB for 28 days
compared with vehicle alone [22]. Injecting fibroblasts into
patient skin can be painful and therefore further studies on
the mode of cell delivery, as well as additional
optimization of the frequency of fibroblast injections and
the amount of cells per injection, will be necessary to
define the clinical utility of allogeneic fibroblast cell
 therapy in the overall management of RDEB (page 3)
Those transplants mostly involved myeloablation
of the RDEB subjects bone marrow followed by sibling-
matched donor grafting. Decreased skin blistering by up to
50 % in half; more than 50 % in the remainder (page 4)
Several patients have reported a reduction in
blister severity from *70 % of their skin surface to *5 %,
although none has been totally cured. (page 4)

Assessment: This source is credible because it is from an academic based

(Analyze and explain database. In addition, these studies were done by scientists that
why this source is specialize in the field of dermatology and have done extensive
credible) research on Epidermolysis Bullosa and effective treatments for the
disease.
15 pts

Reflection: I will use this source by compiling each of these potential

(How will you potentially treatments and basing my treatment plan off of it. If the treatment
use it?) seemed to work then I will use the techniques that they used. I will
also use the pictures included to show the effectiveness of the
25 pts treatment.

Source/ Bibliography:

Hsu, Chao-Kai, et al. "Treatment Of Hereditary Epidermolysis Bullosa: Updates And Future Prospects."

American Journal Of Clinical Dermatology 15.1 (2014): 1-6. Academic Search Complete. Web.

22 Jan. 2017.

Summary:

The clinical research findings by Chao-Kai Hsu called "Treatment Of Hereditary Epidermolysis Bullosa:

Updates And Future Prospects." describes the different treatments that have been tested and it reflects

the results of each treatment option. This source contains different experiments that have been conducted

into figuring out a cure or a better and more effective treatment for sufferers of Epidermolysis Bullosa.

The experimental treatments include: gene therapy, protein replacement therapy, Intradermal Injection of

Allogeneic Fibroblasts, Intradermal Injection of Mesenchymal Stromal Cells, Bone Marrow Stem Cell
Therapy, Natural Gene Therapy: Revertant Mosaicism, and Inducible Pluripotent Stem Cells. This study

elaborates on the effectiveness of the treatment and if it is safe or if there were any difficulties with the

treatment. Although some of these treatments are more effective than others, it highlights on the fact that

there is still not a cure. It also mentions that some of these treatments work better for some people than

others, it all depends on their genetic makeup and the severity of their case.

Potential Quotes:

Several quotes from this source can be used in explaining the different treatments that are effective and

ineffective for diagnosing Epidermolysis Bullosa, such as One study found no difference between

fibroblasts or vehicle in wound healing responses [21], but another trial showed that a single injection of

allogeneic fibroblasts can accelerate wound healing in RDEB for 28 days compared with vehicle alone

[22]. Injecting fibroblasts into patient skin can be painful and therefore further studies on the mode of

cell delivery, as well as additional optimization of the frequency of fibroblast injections and the amount

of cells per injection, will be necessary to define the clinical utility of allogeneic fibroblast cell therapy

in the overall management of RDEB and how Several patients have reported a reduction in blister

severity from *70 % of their skin surface to *5 %, although none has been totally cured. The source

also gives an overview on how some forms of EB require daily changes of wound dressings that can

take several hours to perform and strenuous efforts are needed to maintain adequate mobility and

nutrition, and to limit complications such as skin infection, scarring, dental caries, dysphagia,

constipation, and skin cancer. In one form of treatment, those transplants mostly involved

myeloablation of the RDEB subjects bone marrow followed by sibling-matched donor grafting.

Decreased skin blistering by up to 50 % in half; more than 50 % in the remainder.

Evaluation of source:
This source is credible because it is from an academic based database. In addition, these studies were

done by scientists that specialize in the field of dermatology and have done extensive research on

Epidermolysis Bullosa and effective treatments for the disease.

Reflection:

I will use this source by compiling each of these potential treatments and basing my treatment plan off

of it. If the treatment seemed to work then I will use the techniques that they used. I will also use the

pictures included to show the effectiveness of the treatment. This source is helpful to me because it will

help me come up with the most effective treatment option for patients with epidermolysis bullosa.