Frazier 1
Betsy Frazier
Killingsworth
Honors Mentorship Program
06 November 2016
Annotated Bibliography Graphic Organizer
Pretibial Epidermolysis Bullosa In A Kashmiri Girl
Name: Betsy Frazier
Source #1 Bibliography
(MLA)
10 pts
Annotation:
(Describe ALL info. that
might be important for
your paper. Explain to the
reader and/or summarize
what might be found in
this source)
35 pts
Potential Quotes:
(Are there any significant
quotes you can use or
paraphrase from this
source?)
Annotated Bibliography
Bhat, Yasmeen J., et al. "Pretibial Epidermolysis Bullosa In A
Kashmiri Girl." Indian Journal Of Paediatric Dermatology 16.4
(2015): 203-206. Academic Search Complete. Web. 6 Nov. 2016.
The academic journal, Pretibial epidermolysis bullosa in a
Kashmiri girl by Yasmeen J Bhat, Iffat Hassan, Peerzada Sajad,
and Rohi Wani explains the rare disease known as Epidermolysis
Bullosa and the causes of the disease. EB is characterized by
itching, blisters, atrophy, and scarring localized to the shins. The
journal highlights the fact that this disease is caused by a genetic
mutation within the Type VII Collagen gene. This genetic defect
leads to a lack of collagen in the skin which causes the skin to be
fragile in certain areas, in this case, particularly on the shins. The
case report is viewed by the department of dermatology in India
in order to determine a treatment and to educate the public and
other dermatologists on this disease due to the lack of evidence
and treatments.
- Pretibial epidermolysis bullosa (EB) is a rare type
of dystrophic EB characterized by itching, blisters, atrophy,
and scarring localized to the shins. (Page 203)
- It is caused by mutations within the Type VII
collagen gene (COL7A1) which lead to an alteration of
 Frazier 2

function or to reduced amounts of collagen VII which

15 pts impairs its assembly into anchoring fibrils.[3] This in turn
causes reduced skin resistance to minor trauma. (Page
203)
- The incidence and prevalence of EB are estimated
to be 19.60/million live births and 8.22/ million population.
There is no gender, racial, ethnic or geographical
predilection for EB. (Page 204)
- The lesions would rupture approximately after 34
days time leading to crust formation followed by scarring.
There was no history of mucosal lesions, photosensitivity,
and joint pains. There was no history of such lesions in
other two siblings and her parents. (Page 203)

Assessment: This source is reliable because it is written by scholarly

(Analyze and explain why individuals that are apart of the Department of Dermatology in
this source is credible) India. The other authors have a background in STD, Leprosy, and
Pathology with helps aid their findings. The authors are unbiased,
15 pts because they are not trying to prove anything that would cause
them to be biased, they are just trying to educate people on this
rare disease and discuss the factors of Epidermolysis Bullosa. The
case study was conducted in 2015, which makes it relevant and not
out of date. Furthermore, it was published on Galileo, which
shows that it has academic significance.

Reflection: This academic journal relates to my mentorship because I want to

(How will you potentially be in the medical field and I have recently developed an interest in
use it?) dermatology. This case study can help give me an overview of the
career and help me to realize the tasks that they complete. This in
25 pts depth research can also reveal the strange side of dermatology by
introducing a rare disease. This source adds prevalent information
on the case studies that will be conducted from patient to patient.
In addition, the case study fits under the realm of dermatology and
can help guide me during my research project because it can be an
example of what dermatologists do. I can even provide more
examples and case studies that these dermatologists and
pathologists have examined.

Dermatology case study: Pretibial Epidermolysis Bullosa

 Frazier 3

Source/Bibliography:

Bhat, Yasmeen J., et al. "Pretibial Epidermolysis Bullosa In A Kashmiri Girl." Indian Journal Of

Paediatric Dermatology 16.4 (2015): 203-206. Academic Search Complete. Web. 6 Nov.

2016.

Summary:

The academic journal, Pretibial epidermolysis bullosa in a Kashmiri girl by Yasmeen J

Bhat, Iffat Hassan, Peerzada Sajad, and Rohi Wani explains the rare disease known as

Epidermolysis Bullosa and the causes of the disease. EB is characterized by itching, blisters,

atrophy, and scarring localized to the shins. The journal highlights the fact that this disease is

caused by a genetic mutation within the Type VII Collagen gene. This genetic defect leads to a

lack of collagen in the skin which causes the skin to be fragile in certain areas, in this case,

particularly on the shins. The case report is viewed by the department of dermatology in India in

order to determine a treatment and to educate the public and other dermatologists on this disease

due to the lack of evidence and treatments.

Potential Quotes:

- Pretibial epidermolysis bullosa (EB) is a rare type of dystrophic EB

characterized by itching, blisters, atrophy, and scarring localized to the shins.

- It is caused by mutations within the Type VII collagen gene (COL7A1) which

lead to an alteration of function or to reduced amounts of collagen VII which impairs its

assembly into anchoring fibrils.[3] This in turn causes reduced skin resistance to minor

trauma.
 Frazier 4

- The incidence and prevalence of EB are estimated to be 19.60/million live births

and 8.22/ million population. There is no gender, racial, ethnic or geographical

predilection for EB.

- The lesions would rupture approximately after 34 days time leading to crust

formation followed by scarring. There was no history of mucosal lesions,

photosensitivity, and joint pains. There was no history of such lesions in other two

siblings and her parents.

Evaluation of Source:

This source is reliable because it is written by scholarly individuals that are apart of the

Department of Dermatology in India. The other authors have a background in STD, Leprosy, and

Pathology with helps aid their findings. The authors are unbiased, because they are not trying to

prove anything that would cause them to be biased, they are just trying to educate people on this

rare disease and discuss the factors of Epidermolysis Bullosa. The case study was conducted in

2015, which makes it relevant and not out of date. Furthermore, it was published on Galileo,

which shows that it has academic significance.

Reflection:

This academic journal relates to my mentorship because I want to be in the medical field

and I have recently developed an interest in dermatology. This case study can help give me an

overview of the career and help me to realize the tasks that they complete. This in depth research

can also reveal the strange side of dermatology by introducing a rare disease. This source adds

prevalent information on the case studies that will be conducted from patient to patient. In
 Frazier 5

addition, the case study fits under the realm of dermatology and can help guide me during my

research project because it can be an example of what dermatologists do.