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The Physiologists who are we?

Prof. George Brooks Prof. Steve Lehman Prof. Daniela Kaufer Dr. Darcy Kato Ernst

Dr. Robin Ball


Neurobiology of plasticity

Moelcular Prof.
Neural circuit and Daniela Kaufer
network level plasticity
Physiology Pathology/injury
Behavior cognitive

Social/emotional
Kaufer lab
Collaborators
Inbal Ben-Amie Bartal
Christapher Morrissey UC Berkeley
Aaron Friedman Darlene Francis
George Bentley
Kim long
Lance Kriegsfeld
Vlad Senatorov
George Brooks
Shawn Shirazi Linda Wilbrecht
Lydia Wood
Alon Friedman, DAL
Andrea Nicholas Uwe Heinemann, Charite
Soo young Kim John Huguenard, Stanford
Oscar Vasquez Marion Buckwalter, Stanford
David Prince, Stanford
Alana Wong Francois Tronche, INSERM
Funding
Noopur Amin David Pleasure, UC Davis
Marvin Maze, UCSF
Anna Geraghty
Albert Becker, Bonn
David Covarrubias Tom Neylan, UCSF and SF VA
Luisa Cachueax Mike Rogawsky, UC Davis
Sundari Chetty
Elizabeth Kirby
Sandra Murrow
Kereshmeh Taravosh-Lahn
Dr. Darcy Kato Ernst
Dr. Robin Ball
Prof. Daniela Kaufer
danielak@berkeley.edu Th 9:45-10:45 , first floor OH space, LKS

Dr. Darcy Kato Ernst


darcy.kato@gmail.com Tu 9:30-10:30, 4111b VLSB

Dr. Robin Ball


rwball@berkeley.edu

Email policy: Questions will be answered in class and during office hours and discussion sections. Email should be
reserved for emergency purposes.
Milan Amin Lisa Treidel Ghazal Naseri GSIs

I graduated Integrative Biology I completed my Bachelor's in I have a bachelor's and master's


and Public Health from UC Biology and Psychology in 2012 at degree in Biomedical
Berkeley in 2016. I have since Bucknell University and a Masters Engineering. However, after
been studying the cross in Biology at Illinois State graduating from University of
section of technology and University in 2015. Currently I am a British Columbia I decided to
patient care in a joint UC 2nd year PhD. student in IB, where change my path to optometry. I
Berkeley-UCSF Masters in I work in Dr. Caroline Williams Lab am now a second year
Translational Medicine program to investigate the role of energetics optometry student here at UC
before I continue on to medical in life history evolution. Berkeley.
school in August of this year.
101, 102, 105 103,104, 107
106,108, 109
Text Book:

Human Physiology: An Integrated Approach


Dee Silverthon

7th Edition

Available in book store,


But also used and electronic version.
iClicker
Quiz & lecture participation

Register:
http://www1.iclicker.com/
Syllabus on bCourse
note a new version
was uploaded last
night
What is Physiology?
Homeostasis
What is it?

Who? Or Where are the origins of the concept?


Homeostasis, Walter Cannon:

is the property of a system, either open or closed, that regulates its internal environment and tends
to maintain a stable, constant condition.
Dynamic constancy
CONTROL SYSTEMS:

1.feedback control

The control action is somehow dependent on the output.

Negative feedback control


Positive feedback control

2. Feed forward control


The control action is independent of output.

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Negative Feedback control system

One in which the control action


decreases the effect of any disturbance

Advantages of negative feedback:

- Automatic compensation for disturbances

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________________________

________________________

________________________

________________________

________________________

________________________

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Body temp (cold shivering, hot sweating)

Blood pressure (vasoconstriction and vasodilation)

Blood glucose levels (insulin, glucagon)

Production of red blood cells (EPO)

ATP inhibits PFK

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NEGATIVE FEEDBACK CONTROL OF [ATP] in the Glycolytic
Pathway

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Positive feedback control system

One in which the control action INCREASES


the effect of any disturbance

Advantages of positive feedback:

-Drives system to extreme

- Rapid , automatic response

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Positive feedback examples:

________________________

________________________

________________________

________________________

________________________

________________________

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Positive feedback examples:

-Proliferation of cells in development

-Childbirth

-Sexual arousal

-Voltage dependent Na+ channels in an action potential

-Blood clotting

-Clinical example: epileptic seizures

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Feedforward control system

One in which the control action is


independent of the output

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Advantages of feed-forward control

Can minimize (even eliminate) effects of disturbance

Fast because it anticipates effects of disturbance

Costs of feed-forward control

Needs good prediction (smart controller)

Mistakes can be costly

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Feed-forward examples:

-________________________

-________________________

-________________________

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Feed-forward examples:

- Saliva and acid production when you see food

- preparation for fight or flight response

-Anticipatory postural adjustments


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