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ENDODONTICS
Fifth Edition
2002
BC Decker Inc
Hamilton London
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BC Decker Inc
P.O. Box 620, L.C.D. 1
Hamilton, Ontario L8N 3K7
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2002 BC Decker Inc.
All rights reserved. Without limiting the rights under copyright reserved above, no part of this publication may be reproduced, stored in or intro-
duced into a retrieval system, or transmitted, in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise), without
the prior written permission of the publisher.
Previous edition copyright 1994
02 03 04 05 / UTP / 9 8 7 6 5 4 3 2 1
ISBN 1-55009-188-3
Printed in Canada
Notice: The authors and publisher have made every effort to ensure that the patient care recommended herein, including choice of drugs and
drug dosages, is in accord with the accepted standard and practice at the time of publication. However, since research and regulation constantly
change clinical standards, the reader is urged to check the product information sheet included in the package of each drug, which includes rec-
ommended doses, warnings, and contraindications. This is particularly important with new or infrequently used drugs. Any treatment regi-
men, particularly one involving medication, involves inherent risk that must be weighed on a case-by-case basis against the benefits anticipat-
ed. The reader is cautioned that the purpose of this book is to inform and enlighten; the information contained herein is not intended as, and
should not be employed as, a substitute for individual diagnosis and treatment.
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ACKNOWLEDGMENTS
A number of years ago, I (JII) served on a committee to select a new dean for a school
of medicine. The committee was made up mostly of physicians. I was the only dentist.
The meeting started in the traditional way - each participant stating their name and spe-
cialty. When it came to my turn, I gave my specialty as endodontics.
Over the years I've thought many times of this encounter. How could one write 900
pages about the inside of the tooth? And yet, we have. Because it deserves it!
We have realized for a long time that one person could not be an expert in all phases of
this limited, yet demanding discipline. For that reason we have mustered an assembly of
world experts, each enjoying an international reputation in their particular area of
expertise, be it microanatomy, pathology, pharmacology, microbiology, radiography,
anesthesiology, pain management, canal preparation and obturation, trauma, surgery,
bleaching, pediatric endodontics, whatever.
We are very proud of our contributing authors, and to them we owe an endearing debt
of gratitude. And you~ the reader should as well, for they bring you the finest, stated
honestly and unsparingly!
Once again, I (JII) acknowledge the genuine assistance and loving care I have received
from my wife of 62 years - Joyce Ingle. How fortunate I have been. And likewise, I (LKB)
thank my wife. Grete, for her understanding when I spent numerous hours reading and
writing.
At Loma Linda University, we wish to express our gratitude to the individuals who
helped with the graphics: Richard Tinker and Richard Cross. and the secretaries who so
carefully worked on the text: Luci Denger, Dawn Pellerin, and Marjorie Sweet. Without
their care and dedication, this book would still be just a dream.
Special thanks to Ron and Mary Prottsman for their wonderful indexes.
In addition, we are indebted to Brian Decker, Peggy Dalling and the entire team at BC
Decker Inc for their hard work involved in the preparation of this material.
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The original sign for Pull and Be Damned Road has been pilfered so many times
the authorities have had to place a new sign over 20 feet above ground.
(Courtesy of Dr. James Stephens.)
This book was begun at Snee-oosh Beach, a quiet retreat overlooking Puget Sound and
the San Juan Islands. At Snee-oosh it is possible to escape from complex civilization, and
to concentrate upon the job at handwriting a text.
Hard by Snee-oosh is an old Indian trail called PULL AND BE DAMNED ROAD. One
can hardly imagine a more fitting location while writing a text on the pulpless tooth than
nearby PULL AND BE DAMNED ROAD, for Pull and be damned could well be the
motto of the dental profession from its inception.
PULL AND BE DAMNED ROAD goes down to the shores of Skagit Bay an inside pas-
sage of the gentle Pacific leading ominously to DECEPTION PASS. This delusive inlet
which 50 easily deceived the early explorers reminds us how our profession has prac-
ticed self-deception over the years. Unfortunately, many pass into the pull and be
damned' deceptive phase of dental practice, never to return.
Inside DECEPTION PASS, however, lies HOPE ISLAND, a symbol of the future. HOPE
we must have, coupled with resolve. HOPE that the future of dentistry will noticeably
improve. HOPE that an enlightened profession will be guided by the concept of retention
and rehabilitation of the dental apparatus. HOPE for the rejection of oral amputation.
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viii Preface to the First Edition
To say that the ideas contained within this text are ours or are original is ridiculous.
Nothing really is new under the dental sun. We have liberally borrowed from our con-
temporaries as well as from the past. We only hope we give credit where credit is due.
The student who chooses this text for an encyclopedia will be disappointed. In this
age of do it yourself this is a how to do it book. We have attempted to discuss and
illustrate in great detail the operative aspects of endodontic therapy, for we estimate
that in treating a pulpless tooth the dentist will spend at least 75 percent of treatment
time in endodontic cavity preparation, canal debridement, and filling. Operative
endodontics is therefore presented first in the text, and a correspondingly significant
section deals with these matters.
Diagnosis of pain is an area of dental practice that more frequently is falling into the
province of Endodontics. It has often been said that any well-trained person can practice the
mechanics of dentistry, but that proper diagnosis is the discipline that separates the really
competent dentist from the merely mechanical; hence the extensive coverage of the subject.
A great deal of thought and talent was put into developing the four chapters on the nor-
mal and pathologic pulp and periapical tis-sues. This discussion builds the background
for diagnosis of endodontic problems and sets the stage for a better understanding of
oral and perioral pain.
Snee-oosh Beach is no Walden Pond, nor we Thoreau for that matter. But we may learn
a lesson from Walden. Simplify, simplify! was Thoreaus text, and simplification is one
text we may well take to heart. There has been far too much complicated mumbo-
jumbo in endodontic treatment, a significant factor in discouraging the profession from
including endodontic therapy in their practices.
We will attempt to present the subject not only in a simplified form, but in a systemic
manner; for the simplified systematic practice of endodontics will lead to successful
results achieved with pleasure and profit. We have attempted to remove the mystery and
retain the basic core of the subject. We only hope we succeed in bringing some order out
of the present chaos.
Finally, we would like to eulogize Dr. Balint J. Orban to whom the first edition is dedi-
cated. Dr. Orbans death was a great loss to the profession and an even greater loss to
those of us fortunate enough to have known him well. His ability to clarify and delineate
a problem is apparent in the Classification of Pulpal and Periapical Pain which we dis-
cussed just prior to his death. The profession is forever in the debt of Balint Orban; not
the least for his matchless descriptions of pulpal histopathology. We are proud to be the
recipients of this priceless collection of microscopic material. We are more proud to have
been his friends and disciples.
JOHN INGLE
Seattle, Washington
1964
PREFACE
Thirty-six years ago, this text was started at PULL AND BE DAMNED ROAD. And now,
after a third of a century, we have reached another roada crossroads, as it turns out.
In our fast moving world, the publishing business is approaching a major intersection.
What future directions will be taken: hard copy printing, CD-ROM, Internet, or a com-
bination of all three? This is not a simple fork in the road. This is a freeway interchange,
with more to come for sure.
The authors and publishers of this text were faced with a dilemma, a tectonic shift in
storage and retrieval, so to speak. Should we just abandon the textbook altogether?
Should we grossly reduce the contents and make it a paperback? Should we create a CD-
ROM or a combination of text and CD-ROM? Or should we update the 4th edition to
produce a 5th edition?
We decided on the latter option! BC Decker Inc, our publisher, stated that the text had
become a classic respected worldwide and should continue as the pace-setter, the
landmark, the milestone against which other texts are compared. The endodontic
Bible, if you will.
This text will continue to provide eager students of the discipline with the latest and
most complete information availableunvarnished, impartial, and reliable.
The discipline of endodontics is also reaching a crossroads, brought about by two ele-
mentsnickel and titanium (NiTi). More and more, root canal therapy today is done
with the aid of mechanical means. As new instruments and materials are added,
endodontics will be more precise and less time consuming. But, in this rush to mecha-
nize, let us not forget our major concerns, namely bacteria and pain. We feel that this
new edition of Endodontics addresses well all of these aspects of the discipline.
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CONTRIBUTORS
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xii Contributors
CONTENTS
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xviii Contents
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 951
Chapter 1
MODERN ENDODONTIC THERAPY
John I. Ingle, Leif K. Bakland, Edward E. Beveridge,
Dudley H. Glick, and Anthony E. Hoskinson
Because Ill have you know, Sancho, that a mouth without teeth
is like a mill without its stone, and you must value a tooth more
than a diamond.
Miguel de Cervantes, Don Quixote
point. A more sensible attitude toward endodontic sur- were done in l990.8 By the year 2000, it was estimated
gery developed. that 30 million teeth were root-filled annually.9
During this period, the American Association of This upward trend was also documented by the
Endodontists (AAE) was formed, followed by the Public Affairs Committee of the AAE. Reporting on
American Board of Endodontics. Continuing education surveys of the general public made by the Opinion
in endodontics widely disseminated information, skills, Research Institute in 1984 and 1986, the Committee
and techniques to an eager profession. The prevention noted that 28% of 1,000 telephone respondents report-
of pulp disease began to play a more important role in ed that they had had root canal therapy by 1986, an
dental practice. In part because of fluoridation, there increase of 5% over 23% in 1984.10 Also, in 1986, 62%
was a decline in dental caries. Research into the causes said they would choose root canal therapy over extrac-
and biology of dental trauma led to improved awareness tion, an increase of 10% over 52% in 1984. More than
and treatment of dental injuries. Antibiotics greatly half the respondents (53%) believed that an endodon-
improved the professions ability to control infection, tically treated tooth would last a lifetime.10
while new anesthetics and injection techniques On the other hand, the perceptions of younger peo-
increased control over pain. The high-speed air rotor ple (under 25 years) in this survey were disappointing
handpiece added to patient comfort and the speed and in that 70% described root canal therapy as painful
ease of operation, as did prepackaged sterilized supplies. and 58% thought it would be less expensive to extract
The mandatory use of masks, gloves, and better steriliz- the tooth and place a bridge.10 Clearly, the profession
ing methods rapidly emerged with the spread of human has a mission in educating this age group to reverse
immunodeficiency virus/acquired immune deficiency their image of endodontics and the value of a treated
syndrome (HIV/AIDS) and hepatitis. The widespread pulpless tooth.
use of auxiliaries expanded dental services. A rate of use of endodontic services similar to the
It is now more than two decades since Grossmans rate in the United States (28%) was also reported from
historic report, a period in which new instruments and Norway, where 27% of an older age group (66 to 75
techniques for cleaning and shaping as well as filling years) had had root canal therapy, as had 12% of a
root canals have been introduced. Some of them are younger age group (26 to 35 years). Incidentally, 100%
still in the development stage. All in all, the new decade, of the root-filled teeth in the younger group were still
if not the new millennium, should prove exciting and present 10 to 17 years later, a remarkable achievement.11
profitable for the profession and patients alike. The growth in endodontic services is also reflected
in the sale of endodontic equipment, supplies, and
RECENT ATTITUDES TOWARD DENTISTRY AND instruments. In 1984, endodontics was a $20 million
ENDODONTIC THERAPY market, growing at a rate of 4% a year.12 By 1997, 13
Increasingly, the term root canal has become fashion- years later, the endodontic market, through dental
able and generally known. In conversation, people dealer retail stores alone, was $72 million, up from
proudly proclaim that they have had a root canal. The $65.6 million in 1996, a growth of nearly 10%. One
stigma of fear and pain is fast disappearing. must add to these sales another 10% to account for
Another impressive factor in the acceptance of mail-order/telephone sales, a grand total in 1997 of
endodontics is television. Countless advertisements nearly $80 million. Worldwide sales are probably dou-
emphasize a beautiful smilenot just toothpaste ble this figure!13
advertisements, but commercials in every field, from There is no question that the greatest share of
Buicks to beer. At the same time, the constant barrage endodontic procedures is carried out by Americas gener-
of denture adhesive and cleanser advertisements pro- al practitioners. On the other hand, the specialty of
duces a chilling effect. The public sees the problems endodontics is growing as well. In 1986, for example, only
that develop from the loss of teeth. Obvious missing 5% of those patients who had root canal therapy were
teeth are anathema. treated by a specialist.10 By 1990, this percentage had
There is no question that the publics acceptance of grown to 28.5%.8 In 1989, there were 2,500 endodontic
endodontic treatment is on the rise. In 1969, for exam- specialists in the United States.9 By 2,000, the figure was
ple, the American Dental Association (ADA) estimated around 3,300 endodontists,14 and these endodontists
that 6 million root canal fillings were done each year. were completing 39% of all of the root canal therapy and
By 1990, their estimate had risen to 13,870,000. One endodontic surgery in the United States.8
might add that the ADA also estimated that another In spite of these encouraging figures for the imme-
690,000 endodontic surgeries and root amputations diate future of endodontics, one has to question what
the distant future will bring. The rate of dental caries is $25.3 billion in 1987 and $47.5 billion in 1996.21 In
declining precipitously. 1996, the average person spent $172.70 for dental serv-
In two separate reports, the US National Institute of ices, up from $108 (adjusted to 1996 dollars) in 1967.
Dental Research (NIDR) proudly announced in 1988 This amounts to a 60% increase in outlay for dental
that half of all children in the United States aged 5 to 17 care in 30 years.21
years had no decay in their permanent teeth. None!15 In After all of this expenditure and care, one is hard-
contrast, in the early 1970s, only 28% of the permanent pressed to explain why 15.1 million workdays are lost
teeth of American children were caries free. By 1980, this annually because of dental pain.22
figure had risen to 36.6%, and by 19861987, 49.9%
were caries free. Furthermore, there was a 50% improve- ENDODONTIC CASE PRESENTATION
ment in 17 year olds, a most encouraging sign for den- All of these improvements notwithstanding, many
tists, who were once faced with repairing the ravaged patients still must be convinced that root canal therapy
mouths of adolescents in the 1950s through the 1970s. is an intelligent, practical solution to an age-old prob-
The national decayed-missing-filled surfaces (DMFS) lemthe loss of teeth. The case for endodontic treat-
rate had dropped to 3.1 for all US schoolchildren and, ment must be presented to the patient in a straight-
even more importantly, 82 percent of the DMF surfaces forward manner. The patient with the correct oral
are filled, about 13% decayed and 4% are missing.15 image will be anxious to proceed with therapy.
A comparable radiographic survey in 1980 on 1,059 Is this tooth worth saving, doctor? This sentiment
US Air Force basic trainees 18 to 20 years old found is voiced more often than not by the patient who has
that 10% had no restorations, no decay and no miss- been informed that his or her tooth will require
ing teeth. Moreover, another 10% had at least one root endodontic therapy. Superficially, this appears to be a
canal filling.16 A comparison between these 1980 simple question that requires a direct, uncomplicated
recruits and Navy recruits in 1956 proved that missing answer. It should not be interpreted as hostile or as a
teeth per recruit had dropped from 2.4 to 0.75 in 24 challenge to the treatment recommendations present-
years, a reduction of 31%.16 ed for the retention of the tooth. Psychologically, how-
As far as older adults are concerned, the NIDR ever, this initial question is a prelude to a Pandoras
reported a remarkable decline in edentulism as well, box of additional queries that disclose doubts, fears,
particularly in the middle-aged, a group in which total apprehensions, and economic considerations: for
tooth loss has been practically eliminated.17 The elder- example, Is it painful? Will this tooth have to be
ly (age 65 and older), however, are still in serious trou- extracted later? How long will this tooth last? Is it
ble, root caries and periodontal disease being the pri- a dead tooth? Will it turn black? and How much
mary offenders.17 will it cost?
All of these encouraging figures suggest greater pre- Following the first question, the dentist should
ventive measures and higher use of dental services by anticipate such a series of questions. These may be
the public. Part of the improvement can be credited to a avoided, however, by including the answers to antici-
healthier economy and lifestyle, part to the national pated questions in the presentation. In turn, the dentist
water supply and dentifrice fluoridation programs, part will gain a decided psychological advantage. By this
to the dental professions efforts, and part to dental apparent insight into his or her problems, the patient is
insurance. Bailit et al. have shown that third-party pay- assured that the dentist is cognizant of the very ques-
ment has increased dental use and improved oral tions the patient was about to raise or possibly was too
health.18 By 1995, the ADA estimated that 63% of all US reticent to ask. Most of the patients fear and doubts
citizens were covered by a private insurance program can be allayed by giving a concise answer to each ques-
and another 5.3% by public assistance. A remaining tion. The dentist should be able to explain procedures
31.4% were not covered by any insurance program.19 intelligently as ideas are exchanged with the patient.
In providing these burgeoning services, the dental To do this, one must be endodontically oriented.
profession has fared well financially. Over the past 30 That is, one must believe in the value of endodontic
years, the net income of dentists has more than dou- therapy. By believing in such treatment, one cannot
bled in constant 1967 dollars.20 Moreover, between help but influence the patient favorably. The dentist
1986 and 1995, the net income of dentists rose 30.7%, will soon gain the confidence of the patient who real-
from $102,953 to $134,590.19 izes that professional recommendations emanate
Dental expenditures by the public have increased as from an honest desire to preserve the mouths func-
well, from $3.4 billion in 1967 to $10 billion in 1977, to tional efficiency.23
is necessary to point out to these people the financial Fortunately, todays patient is becoming more
advantage of retaining a tooth by endodontic therapy sophisticated, too tooth conscious to permit indis-
rather than by extraction and prosthetic replacement. criminate extraction without asking whether there is an
The properly informed patient is quick to recognize alternative. Extraction contributes to a crippling aber-
that the fee for a bridge is more than that for root canal ration from the normal dentition. There is no doubt
therapy and proper restoration.10 In addition, it should that a normally functioning, endodontically treated,
be mentioned in all honesty that any vital tooth pre- and well-restored tooth is vastly superior to the best
pared for a crown could become a possible candidate prosthetic or implant replacement.
for future endodontic therapy. Also, the patient who
says Pull it out should be informed of the problems INDICATIONS
that arise if a space is left unfilled (ie, tilting, reduced The indications for endodontic therapy are legion.
masticatory efficiency, future periodontal problems, Every tooth, from central incisor to third molar, is a
and cosmetic effects). potential candidate for treatment. Far too often, the
Another commonly heard statement by the patient expedient measure of extracting a pulpless tooth is a
is, Its only a back tooth, anyway, or If it were a front short-sighted attempt at solving a dental problem.
tooth I would save it, but no one sees it in back. This Endodontic therapy, on the other hand, extends to the
patient thinks cosmetically. The disadvantages of the dentist and the patient the opportunity to save teeth.
loss of any tooth, let alone a posterior one so essential The concept of retaining every possible tooth, and
for mastication, must be explained. even the healthy roots of periodontally involved teeth,
is based on the even distribution of the forces of masti-
cation. The final success of any extensive restorative
procedure depends on the root-surface area attached
through the periodontal ligaments to the alveolar bone.
Like the proverbial horseshoe nail, root-filled teeth may
often be the salvation of an otherwise hopeless case.
To carry this concept one step further, recognized
today is the importance of retaining even endodonti-
cally treated roots, over which may be constructed a
full denture, the so-called overdenture.30 On some
occasions, attachments may be added to these roots to
provide additional retention for the denture above. At
other times, the treated roots are merely left in place on
the assumption that the alveolar process will be
A retained around roots, and there will not be the usual
ridge resorption so commonly seen under full or even
partial dentures.
Most dentists would agree that the retained and
restored individual tooth is better than a bridge replace-
ment and that a bridge is better than a removable par-
tial denture, which, in turn, is superior to a full denture.
Although recent success with dental implants is impres-
sive, the long-term outcome is not known, and, func-
tionally, the patients own tooth is superior. Treatment
in every case should adhere to the standards set by the
dentist for himself or herself and his or her family.
Modern dentistry incorporates endodontics as an
B integral part of restorative and prosthetic treatment.
Most any tooth with pulpal involvement, provided that
Figure 1-5 Fractured premolar restored by endodontics and it has adequate periodontal support, can be a candidate
post-and-core crown. A, Tooth immediately following fracture. B,
Restoration and periradicular healing at 3-year recall. Note the
for root canal treatment. Severely broken down teeth,
spectacular fill of arborization (arrows) at the apex. (Courtesy of and potential and actual abutment teeth, can be candi-
Dr. Clifford J. Ruddle.) dates for the tooth-saving procedures of endodontics.
One of the greatest services rendered by the profes- by their appearance. It is gratifying to see the blossoming
sion is the retention of the first permanent molar personality when an esthetic improvement has been
(Figure 1-6). In contrast, the long-range consequences achieved. The end result in these cases would not be pos-
of breaking the continuity of either arch are also well sible without root canal therapy (Figure 1-10).
known (Figure 1-7). Root canal therapy often provides
the only opportunity for saving first molars with pulp Intentional Endodontics
involvement. Occasionally, intentional endodontics of teeth with
In addition to saving molars for children, saving perfectly vital pulps may be necessary. Examples of sit-
posterior teeth for adults is also highly desirable. uations requiring intentional endodontics include
Retaining a root-filled terminal molar, for example, hypererupted teeth or drifted teeth that must be
means saving two teeththe molars opposite tooth as reduced so drastically that the pulp is certain to be
well (Figure 1-8, A). Moreover, root canal treatment involved.31 On other occasions, a pulp is intentionally
may save an abutment tooth of an existing fixed pros- removed and the canal filled so that a post and core
thesis. The gain is doubled if the salvaged abutment is may be placed for increased crown retention. In these
also the terminal posterior tooth in the arch and has a cases, the endodontic treatment may be completed
viable opponent (Figure 1-8, B). before tooth reduction is started.
Another candidate for endodontic therapy is the ado- Over and above these quite obvious indications for
lescent who arrives in the office with a grossly damaged intentional endodontics, it has been recommended that
dentition and is faced with multiple extractions and den- pulpectomy and root canal filling be done for vital
tures (Figure 1-9). Many of these children are mortified teeth badly discolored by tetracycline ingestion.
A B
C
Figure 1-6 A, Pulpless first molar following failure of pulpotomy. Note two periradicular lesions and complete loss of intraradicular bone.
Draining sinus tract opposite furca is also present. B, Completion of endodontic therapy without surgery. C, Two-year recall radiograph.
Complete healing was evident in 6 months. New carious lesions (arrows) now involve each interproximal surface.
A B
Figure 1-9 A, Caries-decimated dentition in a 14-year-old girl. Personality problems had developed in this youngster related to her feeling
embarrassed about her appearance. B, Provisional restoration following endodontic therapy has restored the cosmetic appearance and con-
fidence so necessary for the adolescent.
during treatment, the patient must be given the option the tooth is anesthetized. The prepared dentist can
of seeing a specialist before the decision to extract the begin pulpectomy immediately, using sterile instru-
tooth is made. ments packaged and stored for just such an emergency.
The well-trained dentist should have no fear of the
pulpally involved tooth. If a carious exposure is noted Age and Health as Considerations
during cavity preparation, the patient is informed of Age need not be a determinant in endodontic therapy.
the problem and the recommended treatment, and, if Simple and complex dental procedures are routinely
consented to, the endodontic therapy is started while performed on deciduous teeth in young children and
A B
Figure 1-10 A, Obvious pulp involvement of incisors shown in Figure 1-9. B, Root canal treatment of these incisors makes possible dowel
restoration followed by cosmetic provisional plastic crowns.
on permanent teeth in patients well into their nineties. Status of the Oral Condition
The same holds true for endodontic procedures. It Pulpally involved teeth may simultaneously have peri-
should be noted, however, that complete removal of the odontal lesions and be associated with other dental
pulp in young immature teeth should be avoided if problems such as rampant decay, orthodontic
possible. Procedures for pulp preservation are more malalignment, root resorption, and/or a history of
desirable and are fully discussed in chapter 15. traumatic injuries. Often the treatment of such teeth
Health consideration must be evaluated for requires a team effort of dental specialists along with
endodontics as it would for any other dental procedure. the patients general dentist.
Most often, root canal therapy will be preferable to The presence of periodontal lesions must be evaluat-
extraction. In severe cases of heart disease, diabetes, or ed with respect to the correct diagnosis: Is the lesion of
radiation necrosis,33 for example, root canal treatment periodontal or endodontic origin, or is it a combined sit-
is far less traumatic than extraction. Even for terminal uation? The answer to that question will determine the
cases of cancer, leukemia, or AIDS, endodontics is pre- treatment approach and the outcome; generally, lesions
ferred over extraction. Pregnancy, particularly in the of endodontic origin will respond satisfactorily to
second trimester, is usually a safe time for treatment. In endodontic treatment alone34 (Figure 1-11), whereas
all of these situations, however, endodontic surgery is those of periodontal origin will not be affected simply by
likely to be as traumatic as extraction. endodontic procedures (Figure 1-12). Combined
A B
A B
C D
Figure 1-12 A, Retraction of surgical flap reveals the extent of periodontal lesion completely involving buccal roots of second molar abut-
ment of full-arch periodontal prosthesis. Root canal therapy of a healthy, palatal root is completed before surgery. B, Total amputation of
buccal roots reveals extent of cavernous periodontal lesion. C, Extensive bone loss, seen in A and B, is apparent in a radiograph taken at the
time of treatment (the root outline was retouched for clarity). D, Osseous repair, 1 year following buccal root amputation. A solidly sup-
ported palatal root serves as an adequate terminal abutment for a full-arch prosthesis. Endodontic therapy was completed in 1959 and has
remained successful. (Courtesy of Dr. Dudley H. Glick.)
lesionsthose that develop as a result of both pulpal caries or horizontal fracture (Figure 1-17), pulpless
infection and periodontal diseaserespond to a com- teeth with tortuous or apparently obstructed canals or
bined treatment approach in which endodontic interven- broken instruments within,40 teeth with flaring open
tion precedes, or is done simultaneously with, periodon- apices (Figure 1-18), teeth that are hopelessly discol-
tal treatment35 (Figure 1-13). Even teeth with apparently ored (Figure 1-19), and even teeth that are wholly or
hopeless root support can be saved by endodontic treat- partially luxated.
ment and root amputation (Figure 1-14). All of these conditions can usually be overcome by
Today, many pulpless teeth, once condemned to endodontic, orthodontic, periodontic, or surgical pro-
extraction, are saved by root canal therapy: teeth with cedures. In some cases, the prognosis may be somewhat
large periradicular lesions or apical cysts3639 (Figure 1- guarded. But in the majority of cases, the patient and
15), teeth with perforations or internal or external dentist are pleased with the outcome, especially if the
resorption (Figure 1-16), teeth badly broken down by final result is an arch fully restored.
A B
Figure 1-15 Classic apical cyst (left) apparent in pretreatment radiograph. Total repair of cystic cavity in 6-month recall film is sig-
naled by complete lamina dura that has developed periradicularly. Biopsy confirmed the initial diagnosis of an apical cyst.
A B
C D
Figure 1-16 A, Extensive defect by internal-external resorp-
tion is demonstrated by an explorer in a 67-year-old man.
B, Retraction of the rectangular flap reveals a pathologic defect
involving over half the tooth. Under no circumstances should
root canal therapy be attempted from this lateral approach.
C, Silver point root canal filling cemented to place before
restoration of resorptive defect. D, Restoration of area of
resorption with zinc-free amalgam. Case is completed by sutur-
ing flap into position. E, Five-year postoperative photograph
(patient, age 72) reveals gingival repair and toleration of sub-
gingival amalgam filling.
E
highest failure rate (16.6%) was in endodontic re-treat- tionthe calcium hydroxide was that effective! They
ment cases. Symptomatic cases were twice as likely to also found a tendency for teeth causing symptoms to
fail as were asymptomatic cases (10.6% versus 5.0%). harbour more bacteria than symptomless teeth.63
A Japanese study followed one-visit cases for as long In a follow-up study, Trope et al. treated teeth with
as 40 months and reported an 86% success rate.50 Oliet apical periodontitis, with and without calcium hydrox-
again found no statistical significance between his two ide, in one or two visits. They reached a number of con-
groups.48 The majority of the postgraduate directors of clusions: (1) [C]alcium hydroxide disinfection after
endodontics felt that the chance of successful healing chemomechanical cleaning will result in negative cul-
was equal for either type of therapy.42 The original tures in most cases; (2) [I]nstrumentation and irriga-
investigators in this field, Fox et al.,43 Wolch,44 tion alone decrease the number of bacteria in the canal
Soltanoff,45 and Ether et al.,46 were convinced that sin- 1000-fold, however the canals cannot be rendered free of
gle-visit root canal therapy could be just as successful as bacteria by this method alone; and (3) [T]he addition-
multiple-visit therapy. None, however, treated the al disinfecting action of calcium hydroxide before obtu-
acutely infected or abscess case with a single visit. ration resulted in a 10% increase in healing rates. This
In more recent times, and in marked contrast to difference should be considered clinically important.66
these positive reports, Sjgren and his associates in In another 52-week comparative study in North
Sweden sounded a word of caution.62 At a single Carolina, of the periapical healing of infected roots [in
appointment, they cleaned and obturated 55 single- dogs] obturated in one step or with prior calcium
rooted teeth with apical periodontitis. All of the teeth hydroxide disinfection, the researchers concluded that
were initially infected. After cleaning and irrigating Ca(OH)2 disinfection before obturation of infected
with sodium hypochlorite and just before obturation, root canals results in significantly less periapical
they cultured the canals. Using advanced anaerobic inflammation than obturation alone.67
bacteriologic techniques, they found that 22 (40%) of One has to ask, therefore, wouldnt it be better to
the 55 canals tested positive and the other 33 (60%) extend one more appointment, properly medicate the
tested negative. canal between appointments, and improve the
Periapical healing was then followed for 5 years. patients chances of filling a bacteria-free canal?
Complete periapical healing occurred in 94% of the 33 Unfortunately, there is a widely held but anecdotal
cases that yielded negative cultures! But in those 22 opinion that current chemomechanical cleaning tech-
cases in which the canals tested positive prior to root niques are superior, predictably removing the entire
canal filling, the success rate of healing had fallen to bacterial flora. If this is so, single-visit treatment of
just 68%, a statistically significant difference.62 In necrotic pulp cases would definitely be indicated.
other words, if a canal is still infected before filling at a However, the research has yet to be published to cor-
single dental appointment, there may be a 26% greater roborate these opinions. Until then, it may be more
chance of failure than if the canal is free of bacteria. prudent to use an intracanal medicament such as cal-
Their conclusions emphasized the importance of elim- cium hydroxide, within a multiple-visit regimen, for
inating bacteria from the canal system before obtura- cases in which a mature bacterial flora is present with-
tion and that this objective could not be achieved reli- in the canal system prior to treatment. Although sin-
ably without an effective intracanal medicament. This gle appointments would be very appropriate in cases
is one limited study, but it was done carefully and pro- with vital pulps, on the other hand, for teeth with
vides the recent evidence correlating the presence of necrotic pulps and periapical periodontitis, and for
bacteria to longer-term outcomes. failed cases requiring retreatment, there may be a risk
rstavik et al. faced up to this problem and studied of lower success rates in the long term. To date, the
23 teeth with apical periodontitis, all but one infected evidence for recommending either one- or multiple-
initially. At the end of each sitting, apical dentin samples visit endodontics is not consistent. The prudent prac-
were cultured anaerobically. No chemical irrigants were titioner needs to make decisions carefully as new evi-
used during cleaning and shaping, and at the end of the dence becomes available.
first appointment, 14 of the 23 canals were still infect- Wolch said it best: In the treatment of any disease,
ed.63 At an earlier time, Ingle and Zeldow, using aerobic a cure can only be effected if the cause is removed.
culturing, found much the same.64,65 rstavik et al. Since endodontic diseases originate from an infected or
then sealed calcium hydroxide in the canal. In 1 week, at affected pulp, it is axiomatic that the root canal must be
the start of the second appointment, only one root canal thoroughly and carefully debrided and obturated
had sufficient numbers of bacteria for quantifica- (personal communication, 1983).
A B
Figure 1-20 Two examples of swallowed endodontic instruments because the rubber dam was not used. A, Radiograph taken 15 minutes
after an endodontic broach (arrow ) was swallowed. Reproduced with permission from Heling B, Heling I. Oral Surg 1977;43:464. B,
Abdominal radiograph showing a broach in the duodenum (arrow). The broach was surgically removed 1 month later. Reproduced with
permission from Goultschin J, Heling B. Oral Surg 1971;32:621.
A major standard of care controversy has also erupt- but were still large enough for the passage of bacteria
ed over the issue of overfilling or overextending the and their toxins.75 Buchanan has shown that with care
root canal filling versus filling short. One would be and persistence, many so-called obliterated canals can
hard-pressed in court to defend gross overfilling, some- be negotiated (personal communication, 1989).
times even to the point of filling the mandibular canal In the light of the low success rate (62.5%) of
(Figure 1-21). On the other hand, a puff of cement unfilled obliterated canals with apical radiolucencies,
from the apical constriction has become acceptable. the dentist must seriously consider a surgical approach
Filling just short of the radiographic apex, at the api- and retrofillings. This would be well within the stan-
cal constriction, 0.5 to 1.0 mm, is backed by a host of dard of care if done expertly.
positive reports. By the same token, an inadequate root Paresthesia is another patient complaint following
canal filling is hardly defensible as rising to the stan- endodontic treatment. Lip numbness (the injection
dard of care, even though the filling might appear to didnt wear off )76 is usually caused by gross overfill-
extend to the apex. ing, nearly always when root canal sealers or cements
Grossly underfilled canals, 3.0 to 6.0 mm short, are impinge on the inferior alveolar nerve. This is particu-
also hard to defend, particularly if an associated peri- larly true when neurotoxic filling materials are used
radicular lesion is radiographically apparent. One must (eg, N2, RC2B, Endomethazone, SPAD).
realize, however, that some root canals are so thor- rstavik et al. surveyed the literature for reported
oughly calcified (obliterated) that penetration to the cases of paresthesia related to endodontic treat-
apex is virtually impossible. ment.76 They found 24 published cases; 86% of
Facing this problem, Swedish scientists analyzed 70 patients were female, and usually a paste-type filling
cases of obliterated canals over a recall period of 2 to had been used. Although 5 cases healed in four
12 years.75 The overall success rate for the partially months to two years, 14 showed no indication of the
filled canals was 89%. If in the initial radiograph there paraesthesia healing...from 3 months up to 18 years.
was an intact periradicular contour, the success rate The remaining cases were resolved by surgical
was an amazing 97.9%. If a preoperative periradicular removal of the offending material. rstavik et al.
radiolucency was present, however, the success rate reported the twenty-fifth case, paresthesia following
dropped to a disappointing 62.5%.75 overfilling with Endomethazone. The condition still
In the incompletely filled failure cases, it was theo- persisted 3 years later and the possibility of regener-
rized that canals were present but so narrow that they ation of the nerve must be considered negligible.76
could not be negotiated by the smallest instruments, Others have reported the same or similar causes of
nerve damage and paresthesia.7780
In California, endodontics became number one in
terms of the frequency of malpractice claims filed.68
Nationally, endodontic claims are the second most fre-
quent producer of claims and dollar losses with oral
surgery being number one.72 There is obviously an
increase in the number of malpractice claims involving
endodontics, primarily against general dentists.73
Many of these tragedies, for dentist and patient alike,
could have been avoided had the patient been referred
to a dentist more skilled in endodontics. When in
doubt, refer it out.74
Just such a tragic casea failure to timely or prop-
erly refer a patientinvolved five dentists enmeshed in
a recent malpractice suit: one general dentist, three
endodontists, and a prosthodontist. None of the four
specialists was board certified, although all were educa-
tionally qualified. The patient was first seen by the gen-
Figure 1-21 Massive overextension of RC2B into the inferior alve-
olar canal. The patient suffered permanent paresthesia. A lawsuit
eral dentist, who took full-mouth radiographs, did an
was settled out of court against the dentist and in favor of the 26- oral examination, and established a treatment plan that
year-old female secretary in Pennsylvania. (Courtesy of Edwin J. said nothing about an unusual bony lesion in the left
Zinman, DDS, JD.) mandible. The patient was not satisfied with the gener-
alist, asked for her radiographs, and transferred to a 1. The complex case involving multiple, dilacerated,
prosthodontist, who also used the original films for his obstructed, or curved canals; malpositioned and
examination. He established that a number of crowns malformed teeth; and complex root morphology. To
and a bridge should be done and that he would start on this one might add unusual radiographic lesions
tooth #19, which had had root canal therapy that failed. that do not appear to be standard periradicular
So, quite properly, he referred the patient to an lesions.
endodontist, who, for some unexplained reason, re- 2. Emergencies in which a patient needs immediate
treated only two of the three canals. Up to this time, all treatment for toothaches, broken crowns, clinical
three dentists had failed to notice the unusual bone tra- exposures, infection, or traumatically injured teeth.
beculation and apparent lesion that extended from the 3. Medically compromised patients with cardiovascu-
mesial of #19 and around the roots of #20 and #21 to lar conditions, diabetes, and blood disorders.
the distal of #22, nor had they noted the buccal swelling 4. Mentally compromised patients, those with a true
in the region! If they had done so, they should have mental disorder and those who have problems with
referred the patient to an oral surgeon, a competent dentistry.
radiologist, or an oral pathologist.
The prosthodontist continued treatment, and, final- Then there is the dentist who is too busy to perform
ly, when the patient complained, noted the swelling in the procedures...81
the vestibule opposite the radiographic lesion. So he To this list, Harman has added, If the general den-
sent her back to the endodontist, who was not in his tist believes that a good and proper diagnosis goes
office, so his associate saw her. The associate stated that beyond his or her abilities, then the dentist should refer
the patient had an abscess and that root canal therapy the patient.82 Nash has estimated that 85 to 90% of all
endodontic referrals come from other dentists.83 The
would have to be done on both teeth, #20 and #21. She
remainder are self-referrals, walk-ins, and patient or
was very displeased with this second endodontist and
physician referrals.
so went to a third, who stated that she had an abscess
The endodontist would much rather receive the
and proceeded to do root canal therapy on tooth #21,
patient at the beginning of treatment than become a
right in the middle of the lesion, which, by this time,
retreat-odontist, retrieving his fellow dentists chest-
had grown almost to the midline. The patient was very
nuts from the fire.
concerned about the swelling, but the endodontist
assured her that it was an abscess that was about to fis- INFORMED CONSENT
tulate, even though there were no other signs of Weichman has pointed out the importance of the doc-
inflammationno redness, no pain, no loss of func- trine of informed consent, as well as other steps that
tiononly swelling. He did not suggest that she be must be taken by the dentist to maintain good patient
referred to an oral surgeon, nor did he aspirate the buc- relations.84 According to the doctrine of informed con-
cal swelling for exudate. He stated that they should sent, a dentist must (1) describe the proposed treat-
watch and wait to see if the root canal therapy ment so that it is fully understood by the patient, (2)
improved the situation. When it did not and the buccal explain all of the risks attendant to such treatment, and
swelling increased, the patient finally went to an oral (3) discuss alternative procedures or treatments that
surgeon. The case was diagnosed as an ameloblastoma, might apply to the patients particular problem.85 To
and the mandible had to be amputated from first molar this should be added (4) the risks associated with doing
to first molar. The case against the five dentists was set- nothing!
tled out of court for nearly one million dollars. The courts have decided that a patient can give a valid
This case is a sad example of dentists so eager to treat or an informed consent for treatment only after receiv-
the patient that they did not thoroughly examine the ing all of this information. If a dentist does not obtain an
evidence that was present, ignored the signs and symp- informed consent, he or she is guilty of professional neg-
toms, and neglected to refer the patient to someone ligence and is liable for any injury resulting from so-
better trained or more competent. called unauthorized treatment. One way of handling this
is to list the options in the patients chart and have the
REFERRALS patient sign. Inform before you perform.68
Just when should an endodontic patient be referred? Weichman points out that, at a minimum, the dentist
Dietz has listed four general categories in which refer- must tell the patient what he or she intends to accom-
ral should be considered81: plish and what any follow-up treatment, such as final
restoration, might entail; the dentist must list other ways on opening the chamber, as well as the results of all
of treating the condition, as well as their advantages and testing before treatment; any possible complications
disadvantages, such as extraction versus root canal ther- foreseen or encountered, such as curved roots, obliter-
apy, and, above all, must discuss possible complica- ated canals, postoperative problems, and associated
tionswhat might go wrong or the fact that the treat- periodontal problems; a list of allergies and illnesses;
ment could lose its effectiveness after a few months.84 any prescription written or medications given, includ-
In spite of this detailed recitation, just informing the ing anesthetics injected; and full disclosure of any pro-
patient is not enough, as a famous court decision has cedural accidents occurring during treatment, such as
made quite clear: The test for determining whether a broken instruments or fractured roots.84
potential peril must be divulged to the patient is its Hourigan emphasized that, at the very least, records
materiality to the patients decision. For the patient to should show the following:
give informed consent, he or she must understand what
the dentist is stating. In other words, technical terms Diagnosis (Dx)
are to be avoided. For example, use numbness rather Treatment (Tx) (eg, carpuleswhat, how many)
than paresthesia. Also, the explanation must be in the Medications (Rx) (what, how much; write out)
language the patient understands (eg, Spanish rather Follow-up (Fx)
than English). It should be pointed out that in some Complications (Cx) (broken instruments, perfora-
states, guaranteeing the outcome of professional serv- tions, patients reaction to anesthetic, etc)86
ices is against the law.
Another type of informed consent is parental con- When records are filled out, abbreviations may be
sent. A minor should never be treated without the writ- used, but the dentist must know what they stand for. If
ten consent of a parent. Again, age of consent varies someone other than the dentist writes on the patients
by state. One may also encounter the emancipated record, the writer must initial the writing. An office
minor, who may give consent. The definition of record of initials and the names they stand for should
emancipated minor also varies by state. be kept for possible future use.
Weichman goes on to list the other aspect of prac- The AAE has suggested an informed consent form
ticing defensive dentistry, maintaining good patient that will cover most situations (Figure 1-22). However,
relations. He recommends showing concern for the the Association has stated that a written consent form
patients welfare by (1) establishing good anesthesia, cannot be used as a substitute for the doctors discus-
(2) anticipating problems such as unavoidable pain sion with each individual patient.87
and forewarning the patient, (3) telephoning patients
after treatment to inquire about their comfort, (4)
placing high priority on emergencies, (5) consulting
with other professionals to provide the best possible
care for each patient, and (6) providing competent
coverage in the event that the dentist is unavailable.84
Selbst has added another caveat. He shows data sug-
gesting an increased incidence of complications associ-
ated with retreatment cases, particularly the retreat-
ment of paste fills. He recommends that special care be
taken to advise the re-treatment patient of this
increased jeopardy.85
Patient Records
The importance of maintaining good patient records,
not just financial ones, is also emphasized by
Weichman.84 These records should consist, at a mini-
mum, of good, well-processed radiographs; a health
history signed by the patient; the patients complaints,
from chief complaint to any variance at subsequent Figure 1-22 Informed consent form for endodontic procedures
appointments; any objective findings made during recommended by the American Association of Endodontists (may
treatment, such as the state of the pulps vitality found be copied and enlarged).
Others have written extensively about informed con- It would be easy to become discouraged about pro-
sent.8892 Bailey and Curley have both noted that viding medical and dental care after reviewing the num-
informed consent was an outgrowth of assault and bat- ber of malpractice suits in recent decades. The fact of the
tery lawthe unauthorized offensive touching without matter is that heightened patient awareness of their
consent.88,89 In 1960, Kansas was the first state to for- rights, and the standard of care to be expected, forces the
malize informed consent applied to dentists. The practi- health care provider to be prudent and careful in caring
tioner must bear in mind that informed consent is the for patients and makes the patient take more responsi-
rule of law rather than just a standard of practice.89 bility for his or her medical and dental health.
Bailey has pointed out the wide variance among
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77. Rowe AHR. Damage to the inferior alveolar nerve during or 86. Hourigan MJ. Oral surgery for the general practitioner. Palm
following endodontic treatment. Br Dent J 1983;153:306. Springs Seminars, Mar., 1989.
78. Cohenca C, Rotstein I. Mental nerve paresthesia associated 87. American Association of Endodontists. Informed consent.
with a non vital tooth. Endod Dent Traumatol 1996;12:298. Communique 1986;3:4.
79. Reeh ES. Messer HH. Long term paresthesia following inad- 88. Bailey B. Informed consent in dentistry. J Am Dent Assoc
vertent forcing sodium hypochlorite through perforation 1985;110:709.
in incisor. Endod Dent Traumatol 1989;5:200. 89. Curley A. Informed consent, past, present and future [bulletin].
80. Joffe E. Complications during root canal therapy following Sacramento (CA): The Dentists Insurance Co.; 1989. p. 3.
accidental extrusion of sodium hypochlorite through the 90. Association Reports, Council on Insurance. Informed consent:
apical foramen. Gen Dent 1991;39:460. a risk management view. J Am Dent Assoc 1987;115:630.
81. Dietz G. A roundtable on referrals. Dent Econ 1987;77:51. 91. Paladino T, Linoff K, Zinman E. Informed consent and record
82. Harman B. Op cit, p. 72. keeping. AGD Impact 1986;14:1.
83. Nash K. Endodontic referrals. Calif Dent Assoc J 1987;15:47. 92. Howard W. A roundtable on referrals. Dent Econ 1987;77:50.
Chapter 2
HISTOLOGY AND PHYSIOLOGY OF
THE DENTAL PULP
David H. Pashley, Richard E. Walton, and Harold C. Slavkin
As the principal source of pain within the mouth and blasts initiate the process of dentin formation.2 Once
as the major site of attention in endodontic treatment, under way, dentin production continues rapidly until the
the pulp warrants direct inspection. By its very location main form of the tooth crown and root is created. Then
deep within the tooth, it defies visualization, other than the process slows, eventually to a complete halt.
its appearance as radiolucent lines on radiographs. Nutrition of the dentin is a function of the odonto-
Occasionally, when required to deal with an accidental- blast cells and the underlying blood vessels. Nutrients
ly fractured cusp, the dentist is afforded a glimpse of exchange across the capillaries into the pulp interstitial
the normal pulp. A pink, coherent soft tissue is noted, fluid, which, in turn, travels into the dentin through the
obviously dependent on its normal hard dentin shell network of tubules created by the odontoblasts to con-
for protection and hence, once exposed, extremely sen- tain their processes.
sitive to contact and to temperature changes. Innervation of the pulp and dentin is linked by the
When pulp tissue is removed en masse from a tooth fluid and by its movement between the dentinal tubules
in the course of, say, vital pulpectomy, the dentist gains and peripheral receptors, and thus to the sensory
a new perspective of the pulp. Here is connective tissue nerves of the pulp proper.3
obviously rich in fluid and highly vascular. After expo- Defense of the tooth and the pulp itself has been
sure to air, the appearance and volume of the tissue speculated to occur by the creation of new dentin in the
change as the fluid evaporates. Another dimension of face of irritants. The pulp may provide this defense by
the physical characteristics of pulp tissue can be demon- intent or by accident; the fact is that formation of lay-
strated by grasping a freshly extirpated vital pulp ers of dentin may indeed decrease ingress of irritants or
between thumb and forefinger in both hands and may prevent or delay carious penetration. The pulp
attempting to pull the pulp apart. Surprisingly, this tiny galvanizes odontoblasts into action or produces new
strand has much the feel of dental floss: it is tough, odontoblasts to form needed hard tissue.
fibrous, and inelastic. This is a reflection of an impor- The defense of the pulp has several characteristics.
tant structural component of the pulp, namely collagen. First, dentin formation is localized. Dentin is produced at
a rate faster than that seen at sites of nonstimulated pri-
FUNCTION mary or secondary dentin formation. Microscopically,
The pulp lives for the dentin and the dentin lives by the this dentin is often different from secondary dentin and
grace of the pulp. Few marriages in nature are marked has earned several designations: irritation dentin, repara-
by a greater interrelationship. Thus it is with the pulp tive dentin, irregular secondary dentin, osteodentin, and
and the four functions that it serves: namely, the for- tertiary dentin.
mation and the nutrition of dentin and the innervation The type and amount of dentin created during the
and defense of the tooth.1 defensive response appear to depend on numerous fac-
Formation of the dentin is the primary task of the tors. How damaging is the assault? Is it chemical, ther-
pulp in both sequence and importance. From the meso-
dermal aggregation known as the dental papilla arises the
specialized cell layer of odontoblasts adjacent and inter-
nal to the inner layer of the ectodermal enamel organ. *Supported, in part, by grant DE 06427 from the National
Ectoderm interacts with mesoderm, and the odonto- Institute of Dental and Craniofacial Research.
mal, or bacterial? How long has the irritant been one that becomes dental papilla mesenchyme and others
applied? How deep was the lesion? How much surface that become progenitor cells for the subsequent devel-
area was involved? What is the status of the pulp at the opment of the periodontium.8,14,15 At this time, multiple
time of response? A second defensive reaction, inflam- and reciprocal signals are secreted by the dental papilla
mation within the pulp at the site of injury, should not mesenchyme, and these signals bind to the extracellular
be ignored. This phenomenon will be explored in more matrix and transmembrane cell receptors along the adja-
detail in chapter 4. cent enamel organ epithelium. A discrete structure with-
in the enamel organ, termed the enamel knot, synthe-
INDUCTION AND DEVELOPMENT OF sizes and secretes a number of additional signals that
DENTIN AND CEMENTUM also participate in the determination for the patterns of
Human tooth development spans an extremely long morphogenesis within the maxillary and mandibular
period of time, starting with the induction of the pri- dentitions: incisiform, caninform, and molariform.12,13
mary dentition during the second month of embryoge-
nesis until completion of the permanent dentition
toward the end of adolescence. The primary dentition
is induced during the fifth week of gestation, and bio-
mineralization begins during the fourteenth week of
gestation. In tandem, the first permanent teeth have
reached the bud stage, and they begin biomineraliza-
tion just prior to birth. The first primary teeth begin to
erupt in children at 6 months of age, and the first per-
manent teeth erupt at 5 to 6 years of age. The third
molars are the last teeth to be formed, and their crown
development is completed between 12 and 16 years of
age. Therefore, the induction and development of the
human dentition persists during embryonic, fetal,
neonatal, and postnatal childhood stages of develop-
ment. Detailed descriptions of the histology and timing
of human tooth development can be readily found in a
number of excellent textbooks.4
Inductive tissue interactions, specifically epitheli-
um-mesenchyme interactions, have been extensively
investigated and characterized throughout the various
stages of tooth crown and root morphogenesis.58 The
developing tooth system has become a well-character-
ized model for defining the molecular mechanisms
required for reciprocal signaling during epithelium-
mesenchyme interactions in crown and root morpho-
genesis and cytodifferentiation.913
It is now evident that the initial inductive signals for
tooth formation are synthesized and secreted from spe-
cific sites defined as odontogenic placodes within the
oral ectoderm that cover the maxillary and mandibular
processes.13 The oral ectodermally derived inductive
signals are received by multiple cognate receptors locat-
ed on the cell surfaces of a specific subpopulation of
cranial neural crestderived ectomesenchymal cells Figure 2-1 Early dental pulp, or dental papilla, exhibiting a cellu-
during the initial induction process and the subsequent lar mass at the center of this tooth bud in the early bell stage. Nerve
dental lamina, bud, and stages of tooth develop- fiber bundles are evident in cross-section as dark bodies apical to
dental papilla yet are absent in the papilla itself. Human fetus, 19
ment813 (Figure 2-1). weeks. Palmgren nerve stain. Reproduced with permission from
During the transition from bud to cap stages, the Arwil T, Hggstrms I. Innervation of the teeth. Transactions Royal
ectomesenchyme provides several cell lineages, including School of Dentistry (Stockholm), 3:1958.
The human genome was basically completed by the for cap stage development and subsequent odontoblast
year 200016; essentially all of the 100,000 regulatory cytodifferentiation. The hierarchy of these molecular
and structural genes within the human lexicon have mechanisms associated with the initiation and subse-
been identified, sequenced, and mapped to specific quent early stages of tooth development is shown in
chromosomal locations. Further, combinations of Figure 2-2.
genes encoded within the human genomic deoxyri- Specific mutations or alternations in one or more of
bonucleic acid (DNA) are now known to be expressed these molecules result in clinical phenotypes including
during development that controls morphogenesis. A cleft lip and/or palate and a range of dental abnormali-
number of these genes have been identified and char- ties with enamel, dentin, cementum, periodontal liga-
acterized as being expressed in the odontogenic pla- ment, or alveolar bone disorders; for example,
code, dental lamina, and the bud, cap, bell, and crown hypodontia or missing teeth as seen in X-linked anhy-
stages of tooth development in either the epithelial or drotic ectodermal dysplasia, which is caused by a muta-
mesenchymal cells or both. Significantly, these genes tion in the gene EDA; familial tooth agenesis, which is
are expressed in various combinations during induc- caused by a mutation in the gene MSX1; and X-linked
tion processes associated with many developing epider- amelogenesis imperfecta, which is caused by a mutation
mal organ systems including the salivary gland, seba- in the gene amelogenin.17,18 Recently, a mutation in the
ceous glands, mammary glands, tooth, hair, and skin gene CBF-alpha1, a transcription factor, was found to
morphogenesis.5 cause cleidocranial dysplasia with hyperdontia.19
The specificity of induction reflects the particular The development of dentin is intriguing for several
combinations of signaling molecules, their cognate cell reasons. First, signals within the inner enamel epithelia
surface receptors, various intracellular signal pathways, of the enamel organ induce adjacent cranial neural
and a large number of transcriptional factors that reg- crestderived ectomesenchymal cells to become pro-
ulate gene expression. These combinations further are genitor odontoblasts. Mutations in either the signaling
modified according to temporal and spatial informa- molecules, cognate receptors, intracellular signal path-
tion during development; the combination used to ways, transcription factors, or extracellular matrix mol-
induce the dental lamina is different than that required ecules can result in severe dental anomalies including
Figure 2-2 Molecular controls for the initiation and early stages of tooth morphogenesis. The initiation or site selection for tooth develop-
ment is controlled by oral ectoderm-derived epithelial fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) through their
signaling pathways. The actions of these signaling pathways or circuits are dependent on the stage and position of development and the com-
bination of transcription factors that are either induced () or repressed (_). This establishes the odontogenic placode. Thereafter, epithe-
lium regulates the adjacent mesenchyme during the bud stage and the mesenchyme then promotes differentiation and influences the adja-
cent inner enamel epithelium through feedback loops in the cap, bell, and crown stages of tooth development. The reader is encouraged to
see the following references for detailed analyses of these morphoregulatory molecules.2,710,14,16
tooth agenesis, hypodontia, and oligodontia and defects tion on root surfaces associated with advanced peri-
in dentin deposition or biomineralization, termed odontitis.22 The available evidence strongly supports
dentinogenesis imperfecta. Several dentin extracellular the hypothesis that enamel organ epithelium-derived
matrix proteinsdentin sialoprotein, dentin matrix cell phenotypes control coronal enamel deposition and
protein, and dentin phosphoproteinare produced by the initiation of acellular cementum formation.23,24
alternative splicing from one single gene product.
Mutations in any one of these encoded sequences, or in ANATOMY
type I collagen, result in dentinogenesis imperfecta. The living pulp, as we have seen, creates and shapes its
Mutations that are limited to type I collagen produce own locale in the center of the tooth. The pulp, under
osteogenesis imperfecta with a form of dentinogenesis normal conditions, tends to form dentin evenly, faci-
imperfecta. olingually and mesiodistally.25 The pulp therefore tends
Following crown morphogenesis, cells from the cer- to lie in the center of the tooth and shapes itself to a
vical loop give rise to Hertwigs epithelial root sheath miniaturization of the tooth. This residence of the pulp
(HERS) cells, which, in turn, induce adjacent dental is called the pulp cavity, and one speaks of its two main
papilla mesenchymal cells to engage in root forma- parts as the pulp chamber and the root canal. The clin-
tion.68 Progressive cell proliferation and migrations ical implications of pulp form and variation are exten-
eventually outline the shape and size of the forming sively covered in chapter 10. Indeed, the key word in
roots. In this developmental process, two interpreta- understanding the gross anatomy of the pulp is varia-
tions are currently being considered. First, evidence is tion. Equally evident in any study of the pulp is the
available to support the hypothesis that HERS cells reduction in size of the chamber and canals with age.
transdifferentiate into cementoblasts and secrete acel- Such reduction in size thus becomes a new variation.
lular cementum matrix.8 Second, evidence is also avail- In addition to changes in pulp size and shape with
able to support the hypothesis that peripheral ectomes- aging, external stimuli also exert an effect. Caries, attri-
enchymal cells penetrate through the HERS and tion, abrasion, erosion, impact trauma, and clinical
become cementoblasts and secrete acellular cemen- procedures are some of the major irritants that may
tum.6,7 Of course, both processes may take place at dif- cause formation of irritation dentin. The clinician
ferent times and positions of cementogenesis. must appreciate the resultant alterations in internal
The understanding of the induction and develop- anatomy that accompany disease and damage of the
ment of cementum has also progressed in recent years. pulp and dentin.
Hertwigs epithelial root sheath cells provide signals
that induce the differentiation of odontoblasts and the Pulp Chamber
formation of the first peripheral layer of dentin. It has At the time of eruption, the pulp chamber of a tooth
been known for almost 100 years that a small percent- reflects the external form of the enamel.1 Anatomy is
age of the human population expresses enamel pearls less sharply defined, but the cusp form is present. Often
along the root surfaces of permanent teeth. These the pulp suggests its original perimeter (and threatens
enamel-like aberrations in cementogenesis are intrigu- its future) by leaving a filament of itself, the pulp horn,
ing and could offer new insights and strategies to within the coronal dentin. A specific stimulus such as
regenerate acellular cementum. caries leads to the formation of irritation dentin on the
Recent advances have indicated that molecules pre- roof or wall of the chamber adjacent to the stimulus. Of
sumed to be uniquely restricted to inner enamel course, with time, the chamber undergoes steady
epithelium and ameloblasts associated with enamel reduction in size as secondary, and irritation dentin is
formation are also expressed in HERS.68 Specifically, produced on all surfaces (Figure 2-3).
ameloblastin has recently been identified in both
ameloblasts and HERS.20 This association between Root Canal
enamel and cementum has been previously discussed An unbroken train of connective tissue passes from the
with respect to coronal cementum.21 These and other periodontal ligament through the apical root canal(s) to
studies have suggested that enamel matrix contains the pulp chamber. Each root is served by at least one such
molecular constitutents, presumably with growth fac- pulp corridor. Actually, the root canal is subject to the
tor bioactivities, that can induce acellular regeneration same pulp-induced changes as the chamber. Its diameter
when active on denuded human dentin root surfaces. becomes narrowed, rapidly at first as the foramen takes
Recently, an enamel matrix preparation has been shape in the posteruptive months but with increasing
demonstrated to induce acellular cementum regenera- slowness once the apex is defined. The canal diameter
Figure 2-5 Features often noted in normal yet aging tooth: devia-
tion of apical foramen as a result of mesial migration of the tooth
(top arrow). Selective resorption and apposition of cementum have
changed the position of the apex, causing narrowing of the apical
third of the root canal by increments of secondary dentin and flar-
Figure 2-4 Canal size and shape are a reflection of the external ing of apical foramen from its smallest diameter at the dentinoce-
root surface. The upper diagrams show the possible canal config- mental junction (bottom arrow) to its greatest diameter at the
urations within each shaped root. The maxillary molar root sec- cemental surface. Note the abundance of collagen fibers in the
tions illustrate that all sizes and shapes of canals may be seen in a radicular pulp. Reproduced with permission from Matsumiya S.
single tooth. Atlas of oral pathology. Tokyo Dental College Press; 1955.
Accessory Canals
Communication of pulp and periodontal ligament is not
limited to the apical region. Accessory canals are found
at every level. Vascular perfusion studies have demon-
strated vividly how numerous and persistent these trib-
utaries are.32 Many, in time, become sealed off by
cementum and/or dentin; however, many remain viable.
The majority appear to be encountered in the apical half
of the root. These generally pass directly from the root
canal to the periodontal ligament (Figure 2-8).
A common area in which accessory canals appear is
the furcation area of molar teeth (Figure 2-9). Burch
and Hulen33 and Vertucci and Anthony34 found that
molars frequently presented openings in the furcation
areas. However, the studies did not determine how
many of these represented patent (continuous) acces-
sory canals all the way from the pulp to the periodon-
tal ligament. Morphologic and scanning electron
microscopic studies consistently show the presence of
Figure 2-6 Diverse ramifications of apical pulp space anatomy.
These models were made by drawing pulps from serial histologic
patent accessory canals or depressions that were
sections and stacking the drawings. Many regions are obviously assumed to be the openings to such canals.3437 In
inaccessible to conventional dbridement methods. Adapted with other studies, dyes were injected or drawn by vacuum
permission from Meyer W. Dtsch Zahnaerztl Z 1970;25:1064. into the furcation of molars. Approximately one half of
A
Figure 2-7 Accessory foramen (arrow) in mandibular anterior
tooth. Accessory foramina are usually located within the apical 2 to
3 mm of root. (Orban collection.) Reproduced with permission
from Sicher H. Oral histology and embryology. 5th ed. St. Louis: CV
Mosby; 1962.
A B
Figure 2-9 Inset demonstrates method of sectioning molars for viewing furcations. A, Foramina of accessory canal indicated by arrow (20
original magnification). B, Foramen seen in A, magnified 1,000. Canal is about 35 microns across, flaring to 60 microns at surface. Note
two peripheral foramina on the rim. Reproduced with permission from Koenigs JG, Brilliant JD, Foreman DW. Oral Surg 1974;38:773.
Plexuses of capillaries and small nerve fibers ramify in Structural Elements, Cellular
this subodontoblastic layer. Deep to the odontoblastic Reserve Cells. The pulp contains a pool of reserve
layer is the cell-rich zone, which blends in turn with the cells, descendants of undifferentiated cells in the primi-
dominant stroma of the pulp. The cell-rich zone con- tive dental papilla. These multipotential cells are likely a
tains fibroblasts and undifferentiated cells, which sus- fibroblast type that retains the capability of dedifferen-
tain the population of odontoblasts by proliferation tiating and then redifferentiating on demand into many
and differentiation.41 of the mature cell types. Beneath the odontoblasts, in
These zones vary in their prominence from tooth to the cell-rich zone, are concentrations of such cells.
tooth and from area to area in the pulp of the same However, Frank demonstrated by radioautography that
tooth. The cell-free and cell-rich zones are usually these cells produce little collagen, which is circumstan-
indistinct or absent in the embryonic pulp and usually tial evidence that they are not mature fibroblasts.42
appear when dentin formation is active. The zones tend Baume has reviewed ultrastructural studies that sug-
to become increasingly prominent as the pulp ages. gest cytoplasmic connections between the odontoblasts
Both of these zones are less constant and less promi- and these subjacent mesenchymal cells.43 Through
nent near the root apex. such connections, on odontoblast injury or death, sig-
Central Pulp Zone. The main body of the pulp nals may be provided to these less differentiated cells
occupies the area circumscribed by cell-rich zones. It that may cause them to divide and differentiate into
odontoblasts or odontoblast-like cells, as required.43
contains the principal support system for the periph-
Also important are the reserve cells scattered
eral pulp, which includes the large vessels and nerves
throughout the pulp, usually in juxtaposition to blood
(Figure 2-11) from which branches extend to supply
vessels. These retain the capacity, on stimulation, to
the critical outer pulp layers. The principal cells are divide and differentiate into other mature cell types.
fibroblasts; the principal extracellular components are For example, mast cells and odontoclasts (tooth resor-
ground substance and collagen. The environment of bers) arise in the presence of inflammation.
the pulp is unique in that it is surrounded by an Significant are the unique cells that differentiate to
unyielding tissue and fed and drained by vessels that form the calcified tissue that develops under a pulp cap
pass in and out at a distant site. However, it is classi- or pulpotomy when calcium hydroxide is placed in
fied as an areolar, fibrous connective tissue, contain- direct contact with the pulp. These unique cells are also
ing cellular and extracellular elements that are found frequently observed along the calcified tissue forming
in other similar tissues. These elements will be dis- at the base of tubules involved with caries, restorations,
cussed in more detail. attrition, or abrasion. This calcified tissue is not a true
A B
Figure 2-10 A, Medium-power photomicrograph from human pulp specimen showing dentin (D), predentin (P), odontoblast layer (O),
cell-free zone (CF), cell-rich zone (CR), and central pulp (CP). B, Region similar to area bracketed in A. Cell-free zone contains large num-
bers of small nerves and capillaries not visible at this magnification. Underlying CR does not have high concentration of cells but contains
more cells than does central pulp. (A and B courtesy of Drs. Dennis Weber and Michael Gaynor.) C, Diagram of peripheral pulp and its prin-
cipal elements. D, Scanning electron micrograph of dentin-pulp junction. Note corkscrew fibers between odontoblasts (arrow). Reproduced
with permission from Jean A, Kerebel JB, Kerebel LM. Oral Surg 1986;61:592. E, Scanning electron micrograph of pulpal surface of odonto-
blast layer. Thread-like structures are probably terminal raveling of nerves. (Courtesy of Drs. R. White and M. Goldman.)
A B C D E
Figure 2-15 Diagram summarizing shape variation of odonto-
blast cell bodies. A, Pulp horn (pear shaped); B, coronal midpulp
level (spindle shape); C, coronal midroot level (elongated club
shape); D, mid-third of root (short club shape); E, apical third of
root (globules). Reproduced with permission from Marion D, et al.
Oral Surg 1991;72:473.
tion to the point of complete occlusion of the tubule Tropocollagen is immature collagen fibers that
(Figure 2-16).8183 When tubule occlusions extend over remain thin and stain black with silver nitrate,
a large area, this is referred to as sclerotic dentin, com- described in light microscopy as argyrophilic or reticu-
monly found in teeth with cervical erosion.44 lar fibrils. If tropocollagen molecules aggregate into
Alternatively, irritated odontoblasts can secrete col- larger fibers, they no longer stain with silver and are
lagen,84 amorphous material, or large crystals into the generally termed collagen fibers. If several collagen
tubule lumen; these occlusions result in decreases in fibers aggregate (cross-link) and grow more dense, they
dentin permeability to irritating substances.8183 are termed collagen bundles. Collagen generally
Although these secretions have been described as a becomes more coarse (ie, develops more bundles) as
defensive reaction by the odontoblast to protect itself the patient ages. Age also seems to permit ectopic calci-
and the underlying pulp, this protection has never fication of pulp connective tissue, ranging from the
been proved. development of random calcifications to diffuse calcifi-
Extracellular. The dental pulp has most of its vol- cations87 to denticle (pulp stone) formation. Elastin,
ume primarily composed of fibers and ground substance. the only other fibrous connective tissue protein, is
These form the body and integrity of the pulp organ. found only in the walls of pulp arterioles.
Fibers. The morphology of collagen fibers, a Collagen has been described as having a unique
principal constituent in the pulp, has been described arrangement in the peripheral pulp; these bundles of
at the level of both light and electron microscopy. At collagen are termed von Korff s fibers. Most textbooks
the ultrastructural level, typical 640 angstrom band- describe von Korff s fibers as being corkscrew-like and
ing or electron-dense periodicity provides positive originating between odontoblasts to pass into the
proof of collagen fiber identity.85 These fibers form a dentin matrix (Figure 2-17). The tight packing of
loose, reticular network to support other structural odontoblasts, predentin, capillaries, and nerves pro-
elements of the pulp. Collagen is synthesized and duces very narrow spaces between and around odonto-
secreted by odontoblasts and fibroblasts. However, the blasts that can retain heavy metal stain (precipitates).
type of collagen secreted by odontoblasts to subse- Ten Cates electron microscopic studies of the distribu-
quently mineralize differs from the collagen produced tion of these precipitates demonstrated their presence
by pulpal fibroblasts, which normally does not calcify. in narrow intracellular tissue spaces.88 He claimed that
They also differ not in basic structure but in the they represented artifactual stains that were not
degree of cross-linking, and in slight variation in attached to collagen fibers.88 However, more recent
hydroxylysine content.86 scanning electron microscopic studies (see Figure 2-10,
Figure 2-16 Mineralization of dentinal tubules in an aging Figure 2-17 Peripheral pulp. The corkscrew-like structures (von
human tooth. Electron micrograph of transparent root dentin from Korff s fibers) reportedly are collagen fibers that originate in the
a 45-year-old person. The more densely mineralized peritubular pulp, pass between odontoblasts, and are incorporated into pre-
dentin is white and the tubule itself is black. Two tubules are visible dentin. That these are collagen fibers is disputed. Reproduced with
in cross-section. The tubule on the left is almost completely occlud- permission from Bernick S.155
ed. The progressive nature of mineralization is evident in the tubule
on the right. (Courtesy of Dr. John Nalbandian.)
A C
Figure 2-19 Corrosion resin casts of the pulp vessels of a dog pre-
molar. A, Higher magnification of the region enclosed by the square
labeled A in C demonstrates many hairpin capillary loops within
the pulp horn (300 original magnification). B, Higher magnifica-
tion of the area enclosed by the square labeled B in C. Arterioles (a)
arborize from artery to form a capillary (c) network on the surface
of the radicular pulp. Venule (V) is about 50 micrometers in diam-
eter. Arterioles are about 10 micrometers in diameter. Superficial
capillary network demonstrates cross-fence shape. C, Montage of
the entire pulp made from multiple, overlapping scanning electron
micrographs (50 original magnification). The three projections in
the coronal region represent three pulp horns, apical foramen (af).
(Courtesy of Drs. K. Takahashi, Y. Kishi, and S. Kim.)
thinner muscular walls (tunica media) than vessels of on venules or permits transudation of fluid across cap-
comparable diameter in other parts of the body. illaries that indirectly compresses the thin-walled
Undoubtedly, this is an adaptation to the surrounding venules in the low-compliance system of the pulp
protective and unyielding walls.102 Kim and his associ- chamber.
ates have obtained evidence that suggests that most The above-described general vascular architecture is
vasodilating agents induce only a transient, brief found in each tooth root. Alternate blood supply is
increase in pulpal blood flow followed by a decrease in available to multicanaled teeth, with the resulting rich
blood flow owing to collapse of local venules.103 anastomoses in the chamber. The occasional vessels
Apparently, the vasodilation either directly impinges that communicate via accessory canals have not been
A
demonstrated to contribute significantly as a source of
collateral circulation.
Lymphatics. The presence of pulpal lymphatics is
disputed.104,105 However, lymphatics have been identi-
fied in the pulp at the ultrastructural98 and histologic
levels by the absence of red blood cells in their lumina,
the lack of overlapping of endothelial margins, and the
absence of a basal lamina.87,98,106108 They arise as lym-
phatic capillaries in the peripheral pulp zone (Figure 2-
22) and join other lymph capillaries to form collecting
vessels.87 These vessels unite with progressively larger
lymphatic channels that pass through the apex with the
other vasculature. Numerous authors, using both histo-
logic and functional methods, have described extensive
anastomoses between lymph vessels of the pulp, peri-
odontal ligament, and alveolar bone.108114
Functional Implications. The presence of arteriove-
nous shunts32,96 in the pulp provides the opportunity
for blood to shunt115,116 past capillary beds since these B
arteriole-venule connections are upstream from the Figure 2-21 A, Electron micrograph of cross-section of the capil-
capillaries. Alternatively, the arteriole-venule shunts lary loop passing between and closely surrounded by odontoblasts.
could remain nearly closed (in a constricted state), and Inset shows higher magnification of a portion of endothelial wall of
most of the blood would pass peripherally in the pulp the capillary demonstrating fenestrations (arrow). B, Subodonto-
to perfuse capillaries and the cells that they support.115 blastic capillary with large nucleus of endothelial cell impinging on
lumen. Plasticity of red blood cell (black) allows it to adapt to irreg-
It has been suggested that the distribution of blood ular contours of lumen. Prominent basement membrane encircles
flow might change during pulp inflammation.117 the periphery of the cell. (A courtesy of Dr. K. Josephsen, Denmark;
Increased dilation of arteriole-venule shunts may pro- B courtesy of Dr. Robert Rapp.)
duce hyperemia, in which more blood vessels than
normal are open and filled with blood cells; this may
indicate more rapid blood flow or represent partial sta- Capillary fenestration may indicate that these capil-
sis. Further, this dilation of arteriole-venule shunts may laries are more permeable to large molecules or that
steal blood from capillary beds, causing accumula- they allow more rapid fluid movement across the
tion of waste products. endothelium.118 However, studies on pulp capillaries
Figure 2-23 Schematic drawing showing sensory nerve location in pulp and dentin. Percentage of innervated tubules at regions A through D
is indicated (left). Px = plexus of Raschkow; cfz = cell-free zone; O = odontoblasts; p = predentin. Reproduced with permission from Byers M.144
theory in which fluid movement within tubules stimu- minal nerves in the injured pulp are sensitive to the
lates distant sensory nerve endings (see Byers et al and noxious products of caries and the restorative proce-
Avery128131 for reviews). dures. An apparent decrease in sensitivity results in
Highly organized junctions have been demonstrated restored teeth. The lack of sensitivity that accompanies
between some nerve fibers and odontoblasts.132136 the caries process may be attributable, at least partially,
Although they do not appear to be typical synaptic to degeneration of underlying nerves.
junctions, their existence must be functional. It is Calcifications. Basically, there are two distinct
unclear whether the activity is sensory or motor. types of pulpal calcifications: formed structures com-
An additional function of sympathetic nerves is the monly known as pulp stones (denticles) and tiny crys-
possible regulation of the rate of tooth eruption. talline masses generally termed diffuse (linear) calcifi-
Sympathetic nerve activity influences local blood flow cations (Figure 2-26). Pulp stones seem to be found
and tissue pressure by opening or closing arteriovenous predominantly in the coronal pulp, whereas the calcifi-
shunts as well as arteriolar blood flow; this may sec- cations found in radicular pulp seem to be of the dif-
ondarily affect eruptive pressure.137 Activation of sym- fuse variety.149
pathetic fibers not only reduces pulpal blood flow138 Calcifications are common in the dental pulp, with a
but also decreases the excitability of intradental tendency to increase with age and irritation. It has been
nerves.139 Thus, there is a very intimate relationship speculated that these calcifications may aggravate or
between pulpal nerves and their excitability and local even incite inflammation of pulp or may elicit pain by
blood flow.140 pressing on structures; however, these speculations
Numbers and concentrations of nerves vary with have not been proved and are improbable. Although
the stage of tooth development and also with location. these calcifications are not pathologic, their presence
Fearnhead and others have reported that very few under certain conditions may be an aid in diagnosis of
nerves appear in the human pulp prior to tooth erup- pulpal disease. Moreover, their bulk and position may
tion.41,141,142 After eruption, the highest number of interfere with endodontic treatment.
nerves is found in the pulp horns (about 40% of the Pulp Stones. These discrete calcific masses appear
tubules are innervated). The number of nerves per with frequency in mature teeth.150 Although there is
tubule drops off to about 4.8% in the more lateral increased incidence with age, they are not uncommon
parts of the coronal dentin to less than 1% in the cer-
vical region (see Figure 2-23), with only an occasional
nerve in radicular dentin.143 Patterns of branching
nerves seen with the light microscope would confirm
numbers of nerves at different levels. There is little
branching off the main nerve bundles until the coro-
nal pulp. Regions of sensitivity also correlate in that
coronal pulp and dentin are more painful to stimuli
than are radicular pulp and dentin. The same stimuli
applied to dentin were described as sharp when
applied to coronal dentin but dull when applied to
radicular dentin.144 Restorative procedures in rat teeth
cause sprouting of pulpal and intradental nerves that
may modify both dentin sensitivity145 and local
inflammatory reactions.146
Interestingly, removal of the pulp by extraction of the
tooth or by pulpectomy and, presumably, pulpotomy
results in the successive degeneration of the cell bodies
located in the spinal nucleus of the trigeminal nerve, the
main sensory ganglion, and the peripheral nerve lead-
ing to the tooth in the socket.147 Bernick observed the
effects of caries and restorations on underlying nerves
in the pulp.148 He found a degeneration of the sub- Figure 2-26 Uninflamed pulp. Typical pattern of calcifications.
odontoblastic plexus of nerves associated with the pro- Larger pulp stones in the chamber blend into linear diffuse calcifica-
duction of irritation dentin. He concluded that the ter- tions in the canal. Reproduced with permission from Bernick S.155
Figure 2-30 Large pulp stones may fill and nearly obscure the entire Figure 2-31 Pattern of dentin formation in aged posterior tooth
chamber. In some areas, the margins of the stone have fused with the from a 60-year-old patient. Typically irregular hard tissue apposi-
dentin walls. Reproduced with permission from Bernick S.155 tion is greatest on the floor, decreasing chamber depth. (Courtesy of
Dr. Sol Bernick.)
Regressive Changes fluid escape and increased pressure within the com-
The term regressive is defined as a condition of partment. The increased tissue pressure collapses veins,
decreased functional capability or of returning to a more thereby increasing the resistance to blood flow through
primitive state. Older pulps have been described as capillaries. Blood is then shunted from areas of high
regressive and as having a decreased ability to combat tissue pressure to more normal areas. Thus, a vicious
and recover from injury. This has been surmised because cycle is produced in which inflamed regions tend to
older pulps have fewer cells, a less extensive vasculature, become more inflamed because they tend to limit their
and increased fibrous elements. In fact, there have never own local nutrient blood flow (Figure 2-35).
been experiments proving that aged pulps are more sus- This is not to say that the pulp strangulation theo-
ceptible to irritants or less able to recover. Until these ry is valid. As shown by Van Hassel,167 and more recent-
have been conclusively demonstrated, the term regres- ly by Nahri168 and Tnder and Kvinnsland,169 pressures
sion is not appropriate, and the dentist should not are not readily transmitted throughout the pulp.
assume that pulps in older individuals are less likely to Therefore, inflammation and increased pressure in the
respond favorably than are younger pulps. coronal pulp will not collapse veins in the apical region.
Pulps physiologically have multiple compartments
PULPAL RESPONSE TO INFLAMMATION throughout. It is as if small volumes of pulp tissue are
Pulp structures and functions are altered, often radical- enclosed in separate connective tissue sheaths, each of
ly, by injury and resulting inflammation. As a part of the which can contain local elevations in tissue pressure.
inflammatory response, neutrophilic leukocytes are Although no histologic evidence exists to support this
chemotactically attracted to the site. Bacteria or dying notion, these functional compartments may break
pulp cells are phagocytosed, causing release of potent down individually to become necrotic and may coalesce
lysosomal enzymes. These enzymes may attack sur- to form microabscesses.
rounding normal tissue, resulting in additional damage. The recent micropuncture work by Tnder and
For instance, by-products of the hydrolysis of colla- Kvinnsland demonstrated that there are highly local-
gen and fibrin may act as kinins, producing vasodila- ized elevations in interstitial tissue pressure in inflamed
tion and increased vascular permeability.162,163 pulp.169 This is thought by some to be caused by the
Escaping fluid tends to accumulate in the pulp intersti- release of vasoactive neuropeptides such as substance P
tial space, but because the space is confined, the pres- and calcitonin generelated peptide, both found in
sure within the pulp chamber rises. This elevated tissue pulp nerve fibers.170 During pulpal inflammation,
pressure produces profound, deleterious effects on the there is an increase in the number of calcitonin
local microcirculation. When local tissue pressure generelated peptidecontaining nerves in areas previ-
exceeds local venous pressure, the local veins tend to ously devoid of nerves. The release of these peptides
collapse, increasing their resistance; hence blood will seems to promote and sustain inflammation, prompt-
flow away from this area of high tissue pressure as it ing some to call it neurogenic inflammation.171
seeks areas of lower resistance. This process of blood
diversion can be illustrated by applying slight pressure PULPODENTINAL PHYSIOLOGY
to the end of a fingernail. As the pressure increases, the As long as dentin is covered peripherally by enamel on
nail bed blanches as blood is squeezed out of the local coronal surfaces and cementum on radicular surfaces,
vessels, and new blood is prevented from flowing the dental pulp will generally remain healthy for life,
through this area of elevated tissue pressure. Persistent unless the apical blood supply is disrupted by excessive
pressure continues to compromise circulation. The orthodontic forces or severe impact trauma. Most
consequences of reduced local blood flow are minor in pathologic pulp conditions begin with the removal of
normal tissue but disastrous in inflamed tissue because one or both of these protective barriers via caries, frac-
the compromised circulation allows the accumulation tures, or abrasion. The result is the communication of
of irritants such as injurious enzymes, chemotoxic fac- pulp soft tissue with the oral cavity via dentinal
tors, and bacterial toxins. tubules, as has been demonstrated by dye penetration
This event may lead to the development of the com- studies172 and radioactive tracer experiments.173
partment syndrome,164166 a condition in which ele- It is apparent that substances easily permeate dentin,
vated tissue pressure in a confined space alters struc- permitting thermal, osmotic, and chemical insults to
ture and severely depresses function of tissues within act on the pulpal constituents. The initial stages involve
that space. Depressed function often leads to cell death, stimulation or irritation of odontoblasts and may pro-
which, in turn, produces inflammation resulting in ceed to inflammation and often to tissue destruction.
To understand how these steps may lead to pulp area of dentin occupied by tubules is only 1% at the
damage, the pulpodentinal complex will be examined dentinoenamel junction and increases to 45% at the
in its separate forms. pulp chamber. The clinical implications of this are
enormous. As dentin becomes exposed to increasing
Dentin Structure depths by restorative procedures, attrition, or disease,
Dentin is a calcified connective tissue penetrated by the remaining dentin becomes increasingly
millions of tubules; their density varies from 40,000 to permeable.179,180 Thus, dentin removal, although nec-
70,000 tubules per square mm.174,175 Tubules are from essary, renders the pulp more susceptible to chemical
1 m in diameter at the dentinoenamel junction to 3 or bacterial irritation. This functional consequence of
m at their pulpal surface and contain fluid that has a tubule area is also responsible for the decrease in dentin
composition similar to extracellular fluid.176 If the microhardness closer to the pulp181,182; as tubule den-
fluid becomes contaminated, for example, with carious sity increases, the amount of calcified matrix between
bacterial endotoxins and exotoxins, then it develops a the tubules decreases. This relative softness of the
reservoir of injurious agents that can permeate through dentin lining the pulp chamber somewhat facilitates
dentin to the pulp to initiate inflammation.177 It is use- canal enlargement during endodontic treatment.183
ful to understand the important variables that control Overall dentin permeability is directly proportional
dentin permeability. to the total surface area of exposed dentin. Obviously, a
Dentin Permeability. Dentinal tubules in the leaking restoration over a full crown preparation pro-
coronal dentin converge from the dentinoenamel junc- vides more diffusional surface for bacterial products
tion to the pulp chamber.178 This tends to concentrate than would a small occlusal restoration.184 Restorations
or focus permeating substances into a smaller area at requiring extensive and deep removal of dentin (ie,
their terminus in the pulp. The surface area occupied preparation for a full crown) would open more and
by tubules at different levels indicates the effect of larger tubules and increase the rate of injurious sub-
tubule density and diameter. One can calculate from stances diffusing from the surface to the pulpthus the
Garberoglio and Brnnstrms175 observations that the importance of remaining dentin thickness.185,186 The
permeability of the root is 10 to 20 times less than that either hand or rotary instruments.193 The smear layer
of a similar thickness of coronal dentin.187 This may prevents bacterial penetration194,195 but permits a wide
account for the lack of pulpal reactions to periodontal range of molecules to readily permeate dentin. Small
therapy that removes cementum and exposes root molecules permeate much faster than large molecules.
dentin to the oral cavity. Smear layers are often slowly dissolved over months to
Recent evidence indicates that dentin permeability is years as oral fluids percolate around microleakage chan-
not constant after cavity preparation. In dogs, dentin nels between restorative materials and the tooth.196
permeability fell over 75% in the first 6 hours following Removal of the smear layer by acid etching or chelation
cavity preparation.188 Although there were no histolog- increases dentin permeability197 because the microcrys-
ic correlates of the decreased permeability, dogs deplet- talline debris no longer restricts diffusion of irritants and
ed of their plasma fibrinogen did not decrease their also permits bacteria to penetrate into dentin.198 There is
dentin permeability following cavity preparation.189 considerable debate as to whether smear layers created in
The authors speculated that the irritation to pulpal the root canal during biomechanical preparation (Figure
blood vessels caused by cavity preparation increased the 2-37) should be removed.199 Its removal may increase the
leakage of plasma proteins from pulpal vessels out into quality of the seal between endodontic filling materials
the dentinal tubules, where they absorb to the dentin, and root dentin. It may also increase the bond strength of
decreasing permeability. Future study of this phenome- resin posts.200
non is required to determine if it occurs in humans. Pulp Metabolism. The rate at which pulpal cells
The character of the dentin surface can also modify are metabolizing can be quantitated by measuring their
dentin permeability. Two extremes are possible: tubules rate of oxygen consumption, CO2 liberation, or lactic
that are completely open, as seen in freshly fractured190 or acid production.201 Fisher and colleagues reported that
acid-etched dentin,191 and tubules that are closed either zinc oxideeugenol (ZOE) cement, eugenol, calcium
anatomically66 or with microcrystalline debris.192 This hydroxide, silver amalgam, and procaine all depressed
debris creates the smear layer (Figure 2-36), which pulp oxygen consumption.202 Shalla and Fisher
forms on dentin surfaces whenever they are cut with demonstrated that lowering the medium pH of pulp
a laser Doppler blood flowmeter that was sensitive nerves cannot be shown in peripheral dentin.143,144
enough to measure changes in pulpal blood flow in Another speculation is that the odontoblastic process
intact human teeth.253 This method has begun to be may serve as excitable nerve endings that would, in
used in pulp biology research.138 Blood flow in the pulp turn, excite nerve fibers shown to exist in deeper dentin,
falls in direct proportion to any increase in pulp tissue closer to the pulp.143,144,257 The experiments of Anderson
pressure. Van Hassel,167 Stenvik and colleagues,241 and and colleagues258 and Brnnstrm259 suggest that neither
Tnder and Kvinnsland169 reported that pulp tissue odontoblastic processes nor excitable nerves within
pressure is elevated in pulpitis but that the elevation is dentin are responsible for dentins sensitivity.
localized within specific regions of the pulp, being nor- This led Brnnstrm and colleagues to propose the
mal in noninflamed areas. The localized reduction in hydrodynamic theory of dentin sensitivity, which sets
pulp blood flow, however, allows the accumulation of forth that fluid movement through dentinal tubules,
mediators of inflammation, which, in turn, causes a moving in either direction, stimulates sensory nerves in
spread in the elevation of tissue pressure, reducing pulp dentin or pulp.259,260 Further support for the hydrody-
blood flow to a larger volume of pulp, etc.167,243 The namic theory came from electron microscopic exami-
elevated pulp tissue pressure causes dull, aching, poor-
nation of animal67,261,262 and human dentin,64,66,67
ly localized pulp pain, a type of pain that differs from
demonstrating that odontoblastic processes seldom
the brief, sharp, well-localized dentinal pain that is pos-
extend more than one-third the distance of the denti-
tulated to be caused by fluid movement within dentin.3
nal tubules. Work by LaFleche and colleagues suggest-
Accordingly, when teeth with elevated pulp pressures
ed that the process may retract from the periphery dur-
are opened to the pulp, the pain generally subsides rap-
ing extraction or processing.77 Obviously, more inves-
idly as tissue pressures rapidly fall.
tigation will be required before any definitive statement
Dentin Sensitivity. Clinicians recognize that dentin
is exquisitely sensitive to certain stimuli.255,256 It is unlike- can be made regarding the distribution of the process.
ly that this sensitivity results from direct stimulation of The tubules are filled with dentinal fluid that is similar
nerves in dentin (Figure 2-39). As previously stated, in composition to interstitial fluid.176
The hydrodynamic theory satisfies numerous exper-
imental observations. Although it cannot yet be regard-
ed as fact, it has provided and will continue to provide
A a very useful perspective for the design of future exper-
iments263265 (see Figure 2-39).
Effect of Posture on Pulpal Pain. Whenever an
appendage is elevated above the heart, gravity acts on
blood on the arterial side to reduce the effective pres-
sure and, hence, appendage blood flow. This is why
ones arm rapidly tires when working overhead. The
B reduced pressure effect occurs in structures in the head
that, in normal upright posture, are well above the
heart. When the patient lies down, however, the gravi-
tational effect disappears, and there is a significant
increase in pulp blood pressure and corresponding rise
in tissue pressure over and above that caused by
endogenous mediators of inflammation. In this posi-
tion, an irritated and inflamed pulp becomes more sen-
sitive to many stimuli and may spontaneously begin to
fire a message of pain. This is why patients with pulpi-
Figure 2-38 Comparison of pulp tissue pressure with systemic tis frequently call their dentists after lying down at
blood pressure in dog. A, Systemic blood pressure, shown on a dif- night. In the supine position, a higher perfusion pres-
ferent sensitivity and scale, demonstrates a mean value of about 120 sure and, presumably, a higher tissue pressure develop
mm Hg and a pulse pressure of about 60 mm Hg. B, Pulp tissue in the patient, which cause more pulp pain. Patients
pressure taken simultaneously with systemic blood pressure and
often discover that they are more comfortable if they
shown on different scale. Pulp tissue pressure demonstrates a mean
value of about 30 mm Hg and a pulse pressure of about 10 mm Hg. attempt to sleep sitting up, which again emphasizes the
(Courtesy of Dr. J. G. Weatherred.) effects of gravity on pulp blood flow.
Another factor contributing to elevated pulp pres- tion of the pain from a dull to a throbbing ache has
sure on reclining is the effect of posture on the activity rational physiologic bases. The lack of documentation
of the sympathetic nervous system. When a person is in the literature is owing to a lack of investigation.
upright, the baroreceptors (the so-called carotid Systemic Distribution of Substances from Dentin and
sinus), located in the arch of the aorta and the bifurca- Pulp. The rate of blood flow115,230,266,267 in the pulp is
tion of the carotid arteries, maintain a relatively high moderately high and falls between that of organs of low
degree of sympathetic stimulation to organs richly perfusion, such as skeletal muscle, and highly perfused
innervated by the sympathetic nervous system. Tnder organs, such as the brain or kidney267 (Figure 2-40). Since
demonstrated that canine pulps showed large reduc- dentinal fluid (the fluid filling the tubules) is in commu-
tions in blood flow when the baroreceptor system was nication with the vasculature of the pulp,240 in theory,
manipulated.226 If the human dental pulp is similar, it substances placed directly on pulp or dentin diffuse to the
would result in slight pulpal vasoconstriction whenev- interstitial fluid and are quickly absorbed into the blood-
er a person is standing or sitting upright. Lying down stream or into the lymphatics. In vivo evidence indicates
would reverse the effect with an increase in blood flow that both may occur. Numerous authors have demon-
and tissue pressure in the pulp. Lying down, then, strated that substances placed onto dentin or into pulp
increases pulp blood flow by removing both the effects chambers are absorbed systemically. These substances
of gravity and the effects of baroreceptor nerves, which include radioactive labeled cortisone,268 tetracycline,269
decrease pulpal vasoconstriction. Thus, the increase in lead,270,271 formocresol,272275 glutaraldehyde,276,277 and
pain from inflamed pulps at night or the transforma- camphorated monochlorophenol.278
This direct communication of dentin to systemic cir- thing to the canal space, indicate how necessary it is to
culation was proved by Pashley,184 who demonstrated respect the periradicular connective tissue.
that radioactive iodide and albumin placed on dog dentin The intimate communicative relationship of the
rapidly gave measurable blood levels of the substances. structures at the periapex has been shown in experi-
Systemic absorption of substances following pulp appli- ments that traced substances placed in the coronal pulp
cation was shown by Myers and colleagues, who meas- to the periodontium. Markers migrated from the pulp
ured the systemic appearance of 131I from pulpotomy and were observed in all areas of the periodontal liga-
sites in monkeys both before and after treatment of the ment, the alveolar and medullary bone, and even in the
pulp stumps with formocresol.276 Similar studies have marginal gingiva.94,108
recently been completed using 14C-formaldehyde274,275 The periapex is the apical continuation of the peri-
and 14C-glutaraldehyde.276,277 Barnes and Langeland odontal ligament. Actually, the tissue at the immediate
demonstrated that circulating antibodies were formed apex of the tooth is more akin to the content of the root
against bovine serum albumin and sheep erythrocytes canal than to the periodontal ligament. The concentra-
placed on exposed pulps of monkeys.120 Thus, the pulp tion of nerves and vessels coursing into the pulp is such,
provides an access route not only to the systemic circula- in fact, that attachment fibers and bone normally asso-
tion but also to the lymphatic system.106 ciated with the ligament space are generally excluded.
Noyes and Ladd forced fluid into dog pulps and The radiographic appearance of the interruption in
observed its collection in submaxillary lymph nodes.279 bone to permit passage of the neurovascular bundle
Kraintz and coworkers placed radioactive colloidal gold must not be confused with the bone resorption that
on dog dentin and found that it appeared in the lym- accompanies periradicular inflammation (Figure 2-42).
phatic drainage.119 Walton and Langeland studied the The connective tissue sheaths of vessel and nerve
distribution of zinc oxide and eugenol from pulpotomy groups lie close together. It is small wonder that inflam-
sites in monkeys.108 Within days, the particles were dis- matory change is found concentrated at this zone of
tributed throughout the pulp (Figure 2-41) and peri- vessel egress; the spread of inflammation occurs via the
odontium and appeared in the submandibular lymph connective tissue sheaths of vessels as a pathway of
nodes of the animals. spread.113,114
Feiglin and Reade deposited radioactive micros- Physiologically, as well as structurally, sharp contrasts
pheres in rat pulps and found more microspheres in set the periodontal ligament apparatus off from pulp tis-
the submandibular lymph nodes in those rats whose sue: (1) It is, for example, an organ of the finest tactile
pulps had been exposed for 5 days in comparison with reception. The lightest contact on the tooth will stimu-
those with acute pulp exposure.280 This suggests late its numerous pressor receptors. The pulp contains
enhanced lymphatic function during inflammation. no such receptors. Proprioceptors of the periodontal lig-
The relationship of teeth to the cardiovascular and ament present the capability of spatial determination. It
lymphatic systems is intimate and absolute. Clinicians is for this reason that an inflamed periodontium can be
should remember this when performing dental proce- more easily localized by the patient than can an inflamed
dures since their placement of materials on dentin or pulp. (2) Collateral blood supply, so lacking within the
pulp may result in widespread distribution of that pulp, is abundant in this area. This rich blood supply is
material or medicament. undoubtedly a major factor in the periapexs ability to
resolve inflammatory disease. In contrast, the pulp often
HISTOLOGY OF THE PERIRADICULAR REGION succumbs to inflammation because it lacks collateral
At the periapex, the connective tissues of root canal, vessels. (3) The apical periodontium communicates with
foramen, and periradicular zone form a tissue continu- extensive medullary spaces of alveolar bone. The fluids
um that is inseparable. This intimate relationship is of inflammation and resultant pressures apparently dif-
confirmed by the frequency of disease in the pulp, fuse through this region more readily than is possible in
inciting disease beyond the tooth. When both the pulp the confined pulp space.
and periapex are jointly involved, immediate therapy Histologically, the periapex demonstrates the major
must often focus on the periradicular region. More features of the remaining periodontium. Collagenous
commonly, only pulp therapy is necessary. Healing of fibers anchor cementum to alveolar bundle bone. The
the periradicular tissue generally occurs spontaneously, arrangement of bone and fibers is discontinuous where
demonstrating its capacity to repair. During prepara- the neurovascular bundle passes through to the pulp. A
tion of the pulp space, the cardinal principles of instru- significant component of the periodontal ligament at all
mentation and obturation, aimed at confining every- levels is the cords of ectodermal cells derived from the
B C
Figure 2-41 Experiment in monkeys showing time and spatial pattern of migration of material placed in contact with vital
pulp. A, Human mandibular first and second molars after pulpotomy; application of a silverzinc oxideeugenol sealer and
restoration with amalgam. Arrow indicates region shown histologically in B and C. B, Area of pulp canal indicated in A.
Particles of silver and zinc oxide are visible in extracellular spaces (E) adjacent to vessels and intracellularly (I) within endothe-
lial or perivascular cells. Material is also contained in venules (V) and in small vessels resembling capillaries, or in lymphatics
(L). C, Same field as B; polarized light demonstrates particles seen in B, which are birefringent sealer particles. Reproduced
with permission from Walton R and Langeland K.108
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in the cat. J Anat 1975;120:169. one. J Dent Child 1985;52:431.
263. Greenhill JD, Pashley DH. The effects of desensitizing agents 275. Ranley DM, Horn D. Assessment of the systemic distribution
on the hydraulic conductance of human dentin, in vitro. J and toxicity of formaldehyde following pulpotomy treat-
Dent Res 1981;60:686. ment: part two. J Dent Child 1987;54:40.
264. Nahri MVO. Dentin sensitivity: a review. J Biol Buccale 276. Myers DR, Pashley DH, Lake FT, et al. Systemic absorption of
1985;13:75. 14C-glutaraldehyde from glutaraldehyde-treated pulpoto-
265. Pashley DH. Dentine permeability, dentine sensitivity and my sites. Pediatr Dent 1986;8:134.
treatment through tubule occlusion. JOE 1986;12:465. 277. Ranley DM, Horn D, Hubbard JB. Assessment of the systemic
266. Kim S, et al. Effects of change in systemic hemodynamic distribution and toxicity of glutaraldehyde as a pulpotomy
parameters on pulpal hemodynamics. JOE 1980;6:394. agent. J Pediatr Dent 1989;11:8.
267. Kim S. Regulation of pulpal blood flow. J Dent Res 278. Fager FK, Messer HH. Systemic distribution of camphorated
1985;64:590. monochlorophenol from cotton pellets sealed in pulp
268. deDeus QD, Hans SS. The fate of 3H-cortisone applied on the chambers. JOE 1986;12:225.
exposed dental pulp. Oral Surg 1967;24:404. 279. Noyes FB, Ladd RL. The lymphatics of the dental region. Dent
269. Page PO, Trump GN, Schaeffer LD. Pulpal studies. I. Passage of Cosmos 1929;71:1041.
3H-tetracycline into circulatory system through rat molar 280. Feiglin B, Reade PC. The distribution of 14C-leucine and 85Sr
pulps. Oral Surg 1973;35:555. microspheres from rat incisor root canals. Oral Surg
270. Oswald RJ, Cohen SA. Systemic distribution of lead from root 1979;47:277.
canal fillings. JOE 1975;1:59. 281. Lindskog S, Blomlf L, Hammarstrm L. Evidence for a role of
271 Chong R, Senzer J. Systemic distribution of 201PbO from root odontogenic epithelium in maintaining the periodontal
canal fillings. JOE 1976;2:301. space. J Clin Periodontol 1988;15:371.
Chapter 3
MICROBIOLOGY OF ENDODONTICS AND
ASEPSIS IN ENDODONTIC PRACTICE
J. Craig Baumgartner, Leif K. Bakland, and Eugene I. Sugita
Microorganisms cause virtually all pathoses of the restorations were a veritable mausoleum of gold over
pulp and the periradicular tissues. To effectively treat a mass of sepsis. He believed that this was the cause of
endodontic infections, clinicians must recognize the Americans many illnesses, including pale complexion,
cause and effect of microbial invasion of the dental chronic dyspepsias, intestinal disorders, anemias, and
pulp space and the surrounding periradicular tissues. nervous complaints.
Once bacterial invasion of pulp tissues has taken place, Soon pulpless teeth (teeth with necrotic pulps) and
both nonspecific inflammation and specific immuno- endodontically treated teeth were also implicated.
logic response of the host have a profound effect on Weston Price began a 25-year study on pulpless and
the progress of the disease. Knowledge of the microor- endodontically treated teeth and their association with
ganisms associated with endodontic disease is neces- focal infection. With expansion of the theory, many
sary to develop a basic understanding of the disease dentists and physicians became 100 Percenters, who
process and a sound rationale for effective manage- recommended the extraction of all pulpless and
ment of patients with endodontic infections. Although endodontically treated teeth. The dental literature con-
the vast majority of our knowledge deals with bacteria, tained numerous testimonials reporting cures of ill-
we are now aware of the potential for endodontic dis- nesses following tooth extraction. These reports were
ease to be associated with fungi and viruses.14 The empirical and without adequate follow-up. However,
topics of this chapter are directed toward the role of they wrongfully supported the continued extraction of
microorganisms in the pathogenesis of endodontic teeth without scientific reason. In many cases, the dis-
disease with recommendations for treatment of eases returned, and the patients had to face the addi-
endodontic infections. Owing to much recent contro- tional difficulty of living with mutilated dentitions.
versy over the theory of focal infection, an update on In the 1930s, editorials and research refuted the the-
this issue will be presented first. ory of focal infection and called for a return to con-
structive rather than destructive dental treatment
THEORY OF FOCAL INFECTION REVISITED rationale.5,6 The studies by Rosenow and Price were
In 1890, W. D. Miller associated the presence of bacte- flawed by inadequate controls, the use of massive doses
ria with pulpal and periapical disease. In 1904, F. of bacteria, and bacterial contamination of endodon-
Billings described a focus of infection as a circum- tically treated teeth during tooth extraction. In 1939,
scribed area of tissue infected with pathogenic organ- Fish recognized four zones of reaction formed in
isms. One of his students was E. C. Rosenow, who in response to viable bacteria implanted in the jaws of
1909 described the Theory of Focal Infection as a guinea pigs.7 He described the bacteria as being con-
localized or generalized infection caused by bacteria fined by polymorphonuclear neutrophil leukocytes to
traveling through the bloodstream from a distant a zone of infection. Outside the zone of infection is the
focus of infection. In 1910, a British physician, William zone of contamination containing inflammatory cells
Hunter, presented a lecture on the role of sepsis and but no bacteria. Next, the zone of irritation contained
antisepsis in medicine to the faculty of McGill histocytes and osteoclasts. On the outside was a zone
University. He condemned the practice of dentistry in of stimulation with mostly fibroblasts, capillary buds,
the United States, which emphasized restorations and osteoblasts. Fish theorized that removal of the
instead of tooth extraction. Hunter stated that the nidus of infection would lead to resolution of the
infection. This theory became the basis for successful to be from 31 to 54%.16 If the endodontic instrument
root canal treatment was confined to inside the root canal 1 mm short of the
Today the medical and dental professions agree that apical foramen, the incidence of bacteremia was 4 in 13
there is no relationship between endodontically treated (31%). If the instruments (sizes 15, 20, and 25) were
teeth and the degenerative diseases implicated in the the- deliberately used to a level 2 mm beyond the apical fora-
ory of focal infection. However, a recent book entitled men, the incidence of bacteremia was 7 in 13 (54%).
Root Canal Cover-up Exposed has resurrected the focal Ribotyping with restriction enzymes showed identical
infection theory based on the poorly designed and out- characteristics for the clinical isolates from the root
dated studies by Rosenow and Price.8 This body of canals and for the bacteria isolated from the blood. This
research has been evaluated and disproved. Un- typing method suggests that the microorganisms recov-
fortunately, uninformed patients may receive this out- ered from the bloodstream during and after endodontic
dated information and believe it to be credible new find- treatment had the root canal as their source. However,
ings. To further confuse the issue, recent epidemiologic to show a causal relationship between an oral infection
studies have found relationships between periodontal and systemic disease, it is not adequate to show only a
disease and coronary heart disease, strokes, and preterm potential relationship via a bacteremia. Hard evidence is
low birth rate.9,10 It must be kept in mind that epidemi- needed to show that the organism in the nonoral site of
ologic research can identify relationships but not causa- infection actually came from the oral cavity. If possible,
tion. Further research may show that periodontal disease Kochs postulates should be fulfilled to establish a causal
constitutes an oral component of a systemic disorder or role of the microorganism from the oral cavity.
has etiologic features in common with medical diseases. Successfully completed root canal therapy should
They may occur at the same time without necessarily not be confused with an untreated infected root canal
indicating a cause-effect relationship. system or a tooth with a periradicular abscess that may
Endodontic infections can spread to other tissues. be a source of bacteremias. In addition, numerous bac-
An abscess or cellulitis may develop if bacteria invade teremias occur every day as a result of a patients nor-
periradicular tissues and the patients immune system mal daily activities. Endodontics has survived the theo-
is not able to stop the spread of bacteria and bacterial ry of focal infection because of recognition by the sci-
by-products. This type of infection/inflammation entific community that successful root canal treatment
spreads directly from one anatomic space to an adja- is possible without endangering systemic health.
cent space. This is not an example of the theory of focal
infection, whereby bacteria travel through the circula- ENDODONTIC INFECTIONS
tory system and establish an infection at a distant site. Colonization is the establishment of microbes in a host
Practitioners are well aware of the relationship if appropriate biochemical and physical conditions are
between bacteremias caused by dental procedures available for growth. Normal oral flora is the result of a
(especially tooth extraction) and infective endocarditis. permanent microbial colonization in a symbiotic rela-
This is an example of focal infection that is not related tionship with the host. Although the microbes in the
to the classic theory of focal infection. A bacteremia normal oral flora participate in many beneficial rela-
associated with a dental procedure introduces bacteria tionships, they are opportunistic pathogens if they gain
into the circulation. It does not arise because of the access to a normally sterile area of the body such as the
mere presence of an endodontically treated tooth. dental pulp or periradicular tissues and produce dis-
Studies have shown that the incidence and extent of a ease. The steps in the development of an endodontic
bacteremia are related to the amount of bleeding (trau- infection include microbial invasion, multiplication,
ma) produced by a dental procedure.1114 These stud- and pathogenic activity. Much of the pathogenic activ-
ies have shown that nonsurgical endodontic proce- ity is associated with host response.
dures produce a relatively low incidence of bacteremia Pathogenicity is a term used to describe the capaci-
when compared to tooth extraction. Simple tooth ty of a microbe to produce disease, whereas virulence
extraction produces an extensive bacteremia 100% of describes the degree of pathogenicity. Bacteria have a
the time.12,15 Endodontic therapy should be the treat- number of virulence factors that may be associated
ment of choice instead of tooth extraction for patients with disease. They include pili (fimbriae), capsules,
believed to be susceptible to infective endocarditis fol- extracellular vesicles, lipopolysaccharides, enzymes,
lowing a bacteremia. short-chain fatty acids, polyamines, and low-molecu-
A recent study found the frequency of bacteremia lar-weight products such as ammonia and hydrogen
associated with nonsurgical root canal instrumentation sulfide. Pili may be important for attachment to sur-
faces and interaction with other bacteria in a polymi- acids. As virulence factors, these acids may affect neu-
crobial infection. Bacteria including gram-negative trophil chemotaxis, degranulation, chemilumines-
black-pigmented bacteria (BPB) may have capsules cence, and phagocytosis. Butyric acid has been shown
that enable them to avoid or survive phagocytosis.17 to have the greatest inhibition of T-cell blastogenesis
Lipopolysaccharides are found on the surface of and to stimulate the production of interleukin-1, which
gram-negative bacteria and have numerous biologic is associated with bone resorption.27
effects when released from the cell in the form of endo- Polyamines are biologically active chemicals found
toxins. The endotoxin content in canals of sympto- in infected canals.28 Bacteria and host cells contain
matic teeth with apical rarefactions and exudate is polyamines. Putrescine, cadaverine, spermidine, and
higher than that of asymptomatic teeth.18 Endotoxins spermine are involved in the regulation of cell growth,
have been associated with periapical inflammation and regeneration of tissues, and modulation of inflamma-
activation of complement.19,20 tion. The amount of total polyamines and putrescine
Enzymes are produced by bacteria that may be is higher in the necrotic pulps of teeth that are painful
spreading factors for infections or proteases that neu- to percussion or with spontaneous pain.28 When a
tralize immunoglobulins and complement compo- sinus tract was present, a significantly greater amount
nents.2124 The enzymes in neutrophils that degenerate of cadaverine was detected in the pulp space.28
and lyse to form purulent exudate also have an adverse Although some correlations between some virulence
effect on the surrounding tissues. factors and clinical signs and symptoms have been
Gram-negative bacteria produce extracellular vesi- shown, an absolute cause and effect relationship has
cles (Figure 3-1). They are formed from the outer not been proven.
membrane and have a trilaminar structure similar to
the outer membrane of the parent bacteria. These vesi- ASSOCIATION OF MICROBES WITH
cles may contain enzymes or other toxic chemicals. It is PULPAL DISEASE
believed that these vesicles are involved in hemaggluti- Antony van Leewenhoek, the inventor of single-lens
nation, hemolysis, bacterial adhesion, and proteolytic microscopes, was the first to observe oral flora.29 His
activities.25,26 Because these vesicles have the same description of the animalcules observed with his
antigenic determinants on their surface as their parent microscopes included those from dental plaque and
bacteria, they may protect the bacteria by combining from an exposed pulp cavity. The father of oral micro-
with and neutralizing antibodies that would have react- biology is considered to be W. D. Miller. In 1890, he
ed with the bacteria. authored a book, Microorganisms of the Human Mouth,
Anaerobic bacteria commonly produce short-chain which became the basis for dental microbiology in this
fatty acids including propionic, butyric, and isobutyric country. In 1894, Miller became the first researcher to
associate the presence of bacteria with pulpal disease.30
The true significance of bacteria in endodontic dis-
ease was shown in the classic study by Kakehashi et al
in 1965.31 They found that no pathologic changes
occurred in the exposed pulps or periradicular tissues
in germ-free rats (Figure 3-2, A). In conventional ani-
mals, however pulp exposures led to pulpal necrosis
and periradicular lesion formation (Figure 3-2, B). In
contrast, the germ-free rats healed with dentinal bridg-
ing regardless of the severity of the pulpal exposure.31
Thus, the presence or absence of microbial flora was
the major determinant for the destruction or healing of
exposed rodent pulps.
Invasion of the pulp cavity by bacteria is most often
associated with dental caries. Bacteria invade and mul-
tiply within the dentinal tubules (Figure 3-3). Dentinal
tubules range in size from 1 to 4 m in diameter,
whereas the majority of bacteria are less than 1 m in
Figure 3-1 Extracellular vesicles are shown between Prevotella diameter. If enamel or cementum is missing, microbes
intermedia cells (20,000 original magnification). may invade the pulp through the exposed tubules. A
A B
Figure 3-2 Role of bacteria in dentin repair following pulp exposure. A, Germ-free specimen obtained 14 days after surgery, with food and
debris in the occlusal exposure. Nuclear detail of surviving pulp tissue (arrow) can be observed beneath the bridge consisting of dentin frag-
ments united by a new matrix. B, Intentional exposure of first molar in control rat (with bacteria 28 days postoperatively). Complete pulp
necrosis with apical abscess. A reproduced with permission from Kakehashi S, Stanley HR, Fitzgerald RJ. Oral Surg 1965;20:340. B repro-
duced with permission from Clark JW, Stanley HR. Clinical Dentistry. Hagerstown (MD): Harper & Row; 1976;4:10.
tooth with a vital pulp is resistant to microbial inva- reactions could result in pulpal necrosis, the majority
sion. Movement of bacteria in dentinal tubules is of pulps were able to undergo healing and repair.3234
restricted by viable odontoblastic processes, mineral- Following trauma and direct exposure of the pulp,
ized crystals, and various macromolecules within the inflammation, necrosis, and bacterial penetration are
tubules. Caries remains the most common portal of no more than 2 mm into the pulp after 2 weeks.35 In
entry for bacteria and bacterial by-products into the contrast, a necrotic pulp is rapidly invaded and colo-
pulpal space. However, bacteria and their by-products nized. Peritubular dentin and reparative dentin may
have been shown to have a direct effect on the dental impede the progress of the microorganisms. However,
pulp even without direct exposure.3234 These studies the dead tracts of empty dentinal tubules following
demonstrated inflammatory reactions opposite the dissolution of the odontoblastic processes may leave
exposed dentinal tubules. Although the inflammatory virtual highways for the microbes passage to the pulp
cavity. Microbes may reach the pulp via direct exposure
of the pulp from restorative procedures or trauma
injury and from pathways associated with anomalous
tooth development.
It is believed that the egress of irritants from an
infected root canal system through tubules, lateral or
accessory canals, furcation canals, and the apical
foramina may directly affect the surrounding attach-
ment apparatus. However, it is debatable whether peri-
odontal disease directly causes pulpal disease.3639 The
presence of pulpitis and bacterial penetration into
exposed dentinal tubules following root planing in
humans has been demonstrated.40 Langeland et al.
found that changes in the pulp did occur when peri-
odontal disease was present, but pulpal necrosis
occurred only if the apical foramen was involved.38
Recently, Kobayashi et al. compared the bacteria in root
canals to those in periodontal pockets.41 The authors
Figure 3-3 Coccal forms of bacteria seen in the cross-section of a believe that bacteria concurrent in both areas suggest
fractured dentinal tubule (15,000 original magnification). that the sulcus or periodontal pocket is the source of
the bacteria in root canal infections. To differentiate an gen for growth and possess both superoxide dismutase
abscess of periodontal origin from that of endodontic and catalase.
origin, the enumeration of spirochetes has been rec- Most species in endodontic infections have also been
ommended.42 Abscesses of periodontal origin con- isolated from periodontal infections, but the root canal
tained 30 to 58% spirochetes, whereas those of flora is not as complex.41 Using modern techniques,
endodontic origin were 0 to 10% spirochetes. five or more species of bacteria are usually isolated
Anachoresis is a process by which microbes may be from root canals with contiguous apical rarefactions.
transported in the blood or lymph to an area of inflam- The number of colony-forming units (CFUs) in an
mation such as a tooth with pulpitis, where they may infected root canal is usually between 102 and 108. A
establish an infection. The phenomenon of anachoresis positive correlation exists between an increase in size of
has been demonstrated in animal models both to non- the periapical radiolucency and both the number of
dental inflamed tissues and inflamed dental pulps.4345 bacteria species and CFUs present in the root canal.52,53
However, the localization of bloodborne bacteria in The dynamics of bacteria in infected root canals
instrumented but unfilled canals could not be demon- have been studied in monkeys.51,54,55 After infecting
strated in an animal mode.46,47 Infection of unfilled the monkey root canals with indigenous oral bacteria,
canals was possible only with overinstrumentation dur- the canals were sealed and then sampled for up to 3
ing the bacteremia to allow bleeding into the canals.47 years. Initially, facultative bacteria predominated; how-
Anachoresis may be the mechanism through which ever, with increasing time, the facultative bacteria were
traumatized teeth with intact crowns become infect- displaced by anaerobic bacteria.51,54,55 The results indi-
ed.48 The process of anachoresis has been especially cate that a selective process takes place that allows
associated with bacteremias and infective endocarditis. anaerobic bacteria an increased capability of surviving
Once the dental pulp becomes necrotic, the root canal and multiplying. After almost 3 years (1,080 days), 98%
system becomes a privileged sanctuary for clusters of of the cultivable bacteria were strict anaerobes.
bacteria, bacterial by-products, and degradation products The root canal system is a selective habitat that
of both the microorganisms and the pulpal tissue.4951 allows the growth of certain species of bacteria in pref-
erence to others. Tissue fluid and the breakdown prod-
PULPAL INFECTION ucts of necrotic pulp provide nutrients rich with
Polymicrobial interactions and nutritional require- polypeptides and amino acids. These nutrients, low
ments make the cultivation and identification of all oxygen tension, and bacterial by-products determine
organisms from endodontic infections very difficult. which bacteria will predominate.
Prior to 1970, very few strains of strict anaerobes were Antagonistic relationships between bacteria may
isolated and identified because of inadequate anaerobic occur. Some metabolites (eg, ammonia) may be either
culturing methods. The importance of anaerobic bac- a nutrient or a toxin, depending on the concentration.
teria in pulpal and periapical pathoses has been In addition, bacteria may produce bacteriocins, which
revealed with the development of anaerobic culturing are antibiotic-like proteins produced by one species of
methods and the use of both selective and nonselective bacteria to inhibit another species of bacteria. When
culture media. However, even with the most sophisti- Sundqvist et al. cultured intact root canals, 91% of the
cated culturing methods, there are still many microor- organisms were strict anaerobes.56 When Baumgartner
ganisms that remain uncultivable. The bacteria in an et al. cultured the apical 5 mm of root canals exposed
infected root canal system are a restricted group com- by caries, 67% were found to be strict anaerobes.57 A
pared to the oral flora. polymicrobial ecosystem seems to be produced that
Most of the bacteria in an endodontic infection are selects for anaerobic bacteria over time. Gomes et
strict anaerobes. These bacteria grow only in the al.58,59 and Sundqvist50,60 used odds ratios to show that
absence of oxygen but vary in their sensitivity to oxy- some bacteria tend to be associated in endodontic
gen. They function at low oxidation-reduction poten- infections. This suggests a symbiotic relationship that
tials and generally lack the enzymes superoxide dismu- may lead to an increase in virulence by the organisms
tase and catalase. Microaerophilic bacteria can grow in in that ecosystem. Clinicians may consider chemome-
an environment with oxygen but predominantly derive chanical cleaning and shaping of the root canal system
their energy from anaerobic energy pathways. as total disruption of that microbial ecosystem.
Facultative anaerobes grow in the presence or absence Although no absolute correlation has been made
of oxygen and usually have the enzymes superoxide between any species of bacteria and severity of endodon-
dismutase and catalase. Obligate aerobes require oxy- tic infections, several species have been implicated with
some clinical signs and symptoms. Those species include apical lesion were factors that had a negative influence
BPB, Peptostreptococcus, Peptococcus, Eubacterium, on the prognosis for re-treatment.80
Fusobacterium, and Actinomyces.53,56,58,6172 Table 3-1 Black-pigmented bacteria have been associated with
shows the percentage of incidence of bacteria isolated clinical signs and symptoms in several stud-
from intact root canals from five combined stud- ies.53,56,58,61,62,6570,72 Unfortunately, taxonomic revi-
ies.53,56,7375 Table 3-2 shows the taxonomic changes that sion based on deoxyribonucleic acid (DNA) studies has
have taken place with the bacteria formerly in the genus made the interpretation of previous research results
Bacteroides. based on conventional identification of the bacteria at
Studies of endodontically treated teeth requiring re- the very least confusing and in many cases impossible.
treatment have shown a prevalence of facultative bac- Conventional identifications of microbes based on
teria, especially Streptococcus faecalis, instead of strict Gram stain, colonial morphology, growth characteris-
anaerobes.7680 In addition, fungi have been shown to tics, and biochemical tests are often inconclusive and
be associated with failed root canal treatment.1,80,81 yield presumptive identifications. Sundqvist described
Infection at the time of refilling and the size of the peri- some of the taxonomic changes that have affected those
species of bacteria often cultured from root canals.82
Previously, Prevotella intermedia was the species of
BPB most commonly isolated from endodontic infec-
Table 3-1 Bacteria Cultured and Identified from the tions. In 1992, isolates previously thought to be
Root Canals of Teeth with Apical Radiolucencies P. intermedia were shown to be a closely related species
now known as P. nigrescens.83 Recent studies have
Bacteria Incidence (%) demonstrated that P. nigrescens is actually the BPB
Fusobacterium nucleatum 48
Streptococcus sp 40
Bacteroides sp* 35 Table 3-2 Recent Taxonomic Changes for Previous
Prevotella intermedia 34 Bacteroides Species
Peptostreptococcus micros 34
Eubacterium alactolyticum 34 Porphyromonasblack-pigmented (asaccharolytic
Peptostreptococcus anaerobius 31 Bacteroides species)
Lactobacillus sp 32 Porphyromonas asaccharolyticas (usually nonoral)
Eubacterium lentum 31 Porphyromonas gingivalis*
Fusobacterium sp 29 Porphyromonas endodontalis*
Campylobacter sp 25 Prevotellablack-pigmented (saccharolytic Bacteroides
Peptostreptococcus sp 15 species)
Actinomyces sp 15 Prevotella melaninogenica
Eubacterium timidum 11 Prevotella denticola
Capnocytophaga ochracea 11 Prevotella loescheii
Eubacterium brachy 9 Prevotella intermedia*
Selenomonas sputigena 9 Prevotella nigrescens
Veillonella parvula 9 Prevotella corporis
Porphyromonas endodontalis 9 Prevotella tannerae
Prevotella buccae 9
Prevotella oralis Prevotellanonpigmented (saccharolytic Bacteroides species)
Proprionibacterium propionicum 8 Prevotella buccae*
Prevotella denticola 6 Prevotella bivia
Prevotella loescheii 6 Prevotella oralis
Eubacterium nodatum 6 Prevotella oris
Prevotella oulorum
*Nonpigmenting species.
Other species isolated in low incidence included Porphyromonas gingi- Prevotella ruminicola
valis, Bacteroides ureolyticus, Bacteroides gracilis, Lactobacillus minu-
tus, Lactobacillus catenaforme, Enterococcus faecalis, Peptostreptococcus *Studies have associated species with clinical signs and symptoms.
prevotii, Eienella corrodens, and Enterobacter agglomerans. Most commonly isolated species of black-pigmented bacteria
Adapted from Sundqvist G.82 from endodontic infections.
most commonly isolated from both root canals and tis matures, it may contain foci of pus consistent with
periradicular abscesses of endodontic origin.8486 an abscess. The relationship of specific species of bacte-
Another study associating BPB with endodontic infec- ria or aggregates of bacteria with the pathogenesis of
tions found BPB in 55% of 40 intact teeth suffering endodontic abscesses/cellulitis has not been estab-
necrotic pulps and apical periodontitis. Sixteen of the lished. Endodontic infections occur when opportunis-
22 teeth in the sample were associated with purulent tic pathogens gain access to the normally sterile dental
drainage or an associated sinus tract.87 Future studies pulp and produce disease. Infections of the root canal
will likely use molecular methods to detect and identi- system may spread to the contiguous periradicular tis-
fy the microbes using extracted DNA. sues. Endodontic abscesses are invariably polymicro-
bial, and several strains of bacteria are cultured from
PULPAL PATHOGENESIS each infection.66,70,95100
Because of the polymicrobial nature of periodontal and The microorganisms identified in periradicular
endodontic disease, a modification of Kochs postulates infections (abscesses) of endodontic origin are similar
has been recommended by Socransky.88,89 This recom- to bacteria isolated and identified from within the root
mendation states that the humoral response to the canal system.53,56,58,6172 Only a few strains of bacteria
organism should be suggestive of its role in the disease. isolated from oral abscesses will produce an abscess in
Jontell et al. have demonstrated the presence of den- pure culture.17,101105 A recent study showed that
dritic cells in the pulp that activate T lymphocytes, Fusobacterium nucleatum, Peptostreptococcus anaero-
which, in turn, direct other immunocompetent cells to bius, and Veillonella parvula, but not any strains of BPB
mount a local immune response.9092 Hahn and Falkler could produce abscesses in pure culture in a mouse
have shown the production by the pulp of model.101 In mixed culture with F. nucleatum, the BPB
immunoglobulin (Ig)G specific for bacteria in deep Prevotella intermedia and Porphyromonas gingivalis
caries.93 In addition, they found an increase in the ratio were significantly more abscessogenic than F. nuclea-
of T helper lymphocytes and B lymphocytes to T sup- tum in pure culture.101 This supports the concept of
pressor cells in response to approaching caries.93 In synergistic relationships between bacteria in an
general, the presence of a mononuclear cell infiltrate endodontic infection. Porphyromonas gingivalis has
(lymphocytes, macrophages, and plasma cells) is also been shown to express collagenase as a potential
indicative of an immune response. Bacterial antigens virulence factor. Porphyromonas endododentalis, how-
activate both T and B cells. This response may be stim- ever, does not appear to possess this same collagenase
ulated by viable bacteria or soluble bacterial compo- gene, prtC.106
nents. Lipopolysaccharides cause polyclonal stimula- Whether asymptomatic chronic apical periodontitis
tion of B cells and induce macrophage activation. lesions (periapical granulomas) are sterile has been
controversial since the beginning of the 1900s.107111 It
PERIRADICULAR INFECTIONS was generally believed that bacteria usually stayed con-
Today we know that serious odontogenic infections, fined to the root canal system of an infected tooth
beyond the tooth socket, are much more common as a except when associated with an abscess or cellulitis. It
result of endodontic infections than as a result of peri- was believed that a granuloma is not an area in which
odontal disease.94 The seriousness of an infection bacteria live, but in which they are destroyed..108 Since
beyond the apex of a tooth depends on the number and then, histologic studies have demonstrated intraradicu-
virulence of the organisms, host resistance, and lar organisms, plaque-like material at the root apex,
anatomic structures associated with the infection. Once intracellular organisms in the body of the inflammato-
the infection has spread beyond the tooth socket, it ry lesions, and extracellular bacteria within the body of
may localize or continue to spread through the bone the lesions1,112114 (Figures 3-4 to 3-7).
and soft tissue as a diffuse abscess or cellulitis. In an elegant study by Nair using both light and elec-
The terms abscess and cellulitis are often used inter- tron microscopy, both intracellular and extracellular
changeably in common clinical use. An abscess is a cav- bacteria were observed within the body of four granulo-
ity containing pus (purulent exudate) consisting of mas and one radicular cyst. Whereas these 5 teeth were
bacteria, bacterial by-products, inflammatory cells, symptomatic and clinically diagnosed as acute periapical
numerous lysed cells, and the contents of those cells. inflammation, 25 other teeth that were asymptomatic
Cellulitis is a diffuse, erythematous, mucosal, or cuta- did not have identifiable extracellular bacteria.115
neous infection that may rapidly spread into deep facial Recently, several investigators have demonstrated
spaces and become life threatening. As a diffuse celluli- the presence of bacteria by culturing lesions diagnosed
A B C
F E D
Figure 3-4 The endodontic flora in the radicular third of periradicularly affected human teeth. The flora appears to be
blocked by a wall of neutrophils (NG in B) or by an epithelial plug (EP in C) in the apical foramen. Note the dense aggre-
gates of bacteria sticking to the dentin wall (AB in B) and similar ones (SB in B) along with loose collections of bacteria
(inset in C) remaining suspended in the root canal among neutrophils. A cluster of an apparently monobacterial colony is
magnified in D. Electron micrographs show bacterial condensation on the surface of the dentin wall, forming thin (E)- or
thick (F)-layered bacterial plaques. The rectangular demarcated portion in A and the circular one in C are magnified in B
and the inset in C, respectively. GR = granuloma; D = dentin. Reproduced with permission from Nair PN.115
C B
Figure 3-5 A radicular plaque invading a resting granuloma. (The rectangular demarcated area in A is magnified in
B.) The well-encapsulated granuloma (GR in A) shows the bacterial front (arrowheads in B and lower inset) deep
within the body of the lesion. Note the funnel-like area of tissue necrosis immediately in front of the apical foramen
(A and B) and the plaque-like bacterial condensation (BA in B and upper inset) along the root dentin. This plaque is
electron microscopically shown in C. The middle inset shows a high magnification of a branching or hyphal-like struc-
ture found among the plaque flora. D = dentin; NG = neutrophilic granulocytes. Reproduced with permission from
Nair PN.115
Figure 3-6 A massive periradicular plaque associated with an acute lesion. Note the mixed nature of the
flora. Numerous dividing cocci (DC, middle inset), rods (lower inset), filamentous bacteria, and spirochetes
(S, upper inset) can be seen. Rods often reveal a gram-negative cell wall (double arrowhead, lower inset), some
of them showing a third outer layer (OL). The circular areas 1, 2, and 3 are magnified in the middle, upper,
and lower insets, respectively. D = dentin; C = cementum; NG = neutrophils. Reproduced with permission
from Nair PN.115
B C D
Figure 3-7 Presence of fungus in the root canal and apical foramen of a root-filled (RF in A and D) tooth with a ther-
apy-resistant periradicular lesion (GR in A and D). The rectangular demarcated area in A is magnified in D. Note the
two clusters of microorganisms located between the dentinal wall (D) and the root filling (arrows in D). Those micro-
bial clusters are stepwise magnified in C and B. The circular demarcated area in B is further magnified in the lower inset
in D. The upper inset is an electron microscopic view of the organisms. They are about 3 to 4 m in diameter and reveal
distinct cell wall (CW), nuclei (N), and budding forms (BU). Reproduced with permission from Nair PN.1
as chronic apical inflammation.113,114,116,117 There is to 15 days.136 After 15 days, the lesion expansion slows,
the possibility of microbial contamination from com- and T suppressor cells outnumber T helper cells. They
munication of the apical tissues with bacteria located believe that T helpermediated activities may involve
in the apical foramen or the oral cavity or during a sur- bone destruction and lesion expansion. Others believe
gical procedure and collection of the microbial sample. that lymphocyte proportion may shift in response to
Depending on the hosts resistance and the virulence population shifts in microorganisms.55,60,137
of the bacteria, invasion of the periradicular tissues The periapical inflammatory responses that occur
may occur from time to time. Perhaps asymptomatic following bacterial infection of the root canal system
periradicular inflammatory lesions (granulomas) may result in the formation of granulomas and cysts with
contain invading bacteria and even abscesses (microab- the resorption of surrounding bone. Interleukin-1 and
scesses) not clinically detectable. If the opportunistic prostaglandins have been especially associated with
organism is successful in invading and establishing an periapical bone resorption. Research is showing that
infection, a clinically apparent abscess and possibly a these inflammatory responses are very complex and
cellulitis may develop (phoenix abscess). Further consist of several diverse elements.138 Prostanoids,
research is needed to clarify this aspect of endodontic kinins, and neuropeptides are endogenous mediators
infections. responsible for intermediate-type responses that
include vasodilatation, increased vascular permeability,
PERIADICULAR PATHOGENESIS and leukocyte extravasation. Bacteria and their by-
Research has shown that periradicular inflammatory products produce nonspecific immune responses
tissue is capable of an immunologic response to bacte- including neutrophil and monocyte migration/activa-
ria. Studies using an enzyme-linked immunosorbent tion and cytokine production. Chronic apical peri-
assay (ELISA), radioimmunosorbent tests, and radial odontitis also involves specific T lymphocyte and B
immunodiffusion assays have detected IgG, IgA, IgM, or lymphocytemediated antibacterial responses. Figure
IgE in fluids of explant (tissue) cultures of endodontic 3-8 shows some of the interactions believed to be asso-
periapical lesions.118122 A DOT-ELISA was used to ciated with bone resorption.
show that BPB (P. intermedia, P. endodontalis, and P.
gingivalis) were the bacteria most reactive with IgG pro- TREATMENT OF ENDODONTIC
duced by explant cultures of periapical lesions.120 An ABSCESSES/CELLULITIS
ELISA has also been used to show an increase in serum The vast majority of infections of endodontic origin
IgG reactive with P. intermedia in patients with peri- can be effectively managed without the use of antibi-
odontal disease or combined endodontic-periodontal otics. Systemically administered antibiotics are not a
disease.123 Recently, exudates from root canals associat- substitute for proper endodontic treatment. Chemo-
ed with symptomatic periapical lesions were shown to mechanical dbridement of the infected root canal sys-
contain higher concentrations of -glucuronidase and tem with drainage through the root canal or by inci-
interleukin-1.124 Those with severe involvement had sion and drainage of soft tissue will decrease the
higher IgG, and those with a sinus tract or swelling con- bioburden so that a normal healthy patient can begin
tained higher concentrations of IgM. the healing process. Antibiotics are not recommended
Numerous studies have quantitatively analyzed the for healthy patients with a symptomatic pulpitis, symp-
lymphocytes and their subsets in periapical tomatic apical periodontitis, draining sinus tract, or
lesions.125134 Periapical lesions associated with localized swelling of endodontic origin or following
untreated teeth have a denser inflammatory cell infil- endodontic surgery.139,140
trate than periapical lesions associated with treated An antibiotic regimen should be prescribed in
teeth.135 No associations were seen between the histo- conjunction with proper endodontic therapy when
logic diagnosis, clinical signs and symptoms, or radi- there are systemic signs and symptoms or a progres-
ographic size of the lesions. Most studies have shown sive/persistent spread of infection. The presence of a
that the majority of lymphocytes in periapical lesions fever (>100F), malaise, cellulitis, unexplained tris-
associated with untreated teeth are T cells. However, mus, and progressive swelling are all signs and symp-
with treated teeth, Alavi et al. found that half of all toms of systemic involvement and the spread of infec-
inflammatory lesions associated with endodontically tion (Table 3-3). Under these circumstances, an
treated teeth had more B than T cells.135 In a rat model, antibiotic is indicated in addition to dbridement of
Stashenko and Wang showed that T helper cells out- the root canal harboring the infection and drainage of
number T suppressor cells during lesion expansion up any accumulated purulence.
For serious infections when the patient is allergic to made major changes in their updated recommenda-
penicillin, clindamycin is effective against both faculta- tions.145 Their guidelines are meant to aid practitioners
tive and strict anaerobic bacteria associated with but are not intended as the standard of care or as a sub-
endodontic infections. It is well distributed throughout stitute for clinical judgment. The incidence of endo-
the body, especially to bone, where its concentration carditis following most procedures on patients with
approaches that of plasma. underlying cardiac disease is low. A reasonable
Metronidazole is a synthetic antimicrobial agent approach for prescribing prophylactic antibiotics con-
with excellent activity against anaerobic bacteria; siders the degree to which the underlying disease creates
however, it is ineffective against facultative bacteria. It a risk for endocarditis, the apparent risk for producing
is a valuable antimicrobial agent in combination with a bacteremia, adverse reactions to the prophylactic
penicillin when penicillin alone has been ineffective. antibiotic, and the cost-benefit aspect of the regimen.145
When antibiotics are prescribed in conjunction with The incidence of bacteremia has been shown to be
dbridement of the root canal system and drainage of low during root canal therapy; however, a transient bac-
purulence, significant improvement should be seen teremia can result from the extrusion of the microor-
within 24 to 48 hours. If the infection is not resolving, ganisms infecting the root canal beyond the apex of the
the diagnosis and initial treatment should be reviewed. tooth.11,12,14 In addition, care must be taken when posi-
If another source of the infection is not found or if tioning rubber dam clamps and accomplishing other
additional attempts for drainage are unsuccessful, the dental procedures that may produce bleeding with an
addition of metronidazole (250 mg every 6 hours) to accompanying bacteremia. Medically compromised
penicillin is indicated. Because metronidazole is effec- dental patients who are at risk of infection should
tive only against anaerobic bacteria, penicillin should receive a regimen of antibiotics that either follows the
be continued to treat any facultative bacteria present. recommendations of the AHA or an alternate regimen
For a more detailed discussion of the role of antibi- determined in consultation with the patients physi-
otics in endodontics, the reader is referred to chapter 18. cians.145 Table 3-4 gives the antibiotic regimens recom-
mended for dental procedures.145 It is believed that the
PROPHYLACTIC ANTIBIOTICS FOR MEDICALLY antibiotics amoxicillin, ampicillin, and penicillin V are
COMPROMISED PATIENTS equally effective against alpha-hemolytic streptococci;
Prophylactic antibiotic coverage may be indicated for however, amoxicillin is recommended because it is bet-
medically compromised patients requiring endodontic ter absorbed from the gastrointestinal tract and pro-
treatment. The American Heart Association (AHA) has vides higher and more sustained serum levels.145
For more complete details concerning antibiotic on a swab, it should be quickly placed in pre-reduced
prophylaxis, the reader is referred to chapter 18 and to medium for transport to the laboratory.
the reports by Strom et al.146 and Durack.147 Good communication with the laboratory person-
nel is important. The sample should be Gram-stained
COLLECTION OF A MICROBIAL SAMPLE to demonstrate which types of microorganisms pre-
Adjunctive antibiotic therapy for endodontic infections dominate. The culture results should show the promi-
is most often prescribed empirically based on our nent isolated microorganisms and not just be identified
knowledge of the bacteria most often associated with as normal oral flora. Antibiotics can usually be cho-
endodontic infections. At times, culturing may provide sen to treat endodontic infections based on the identi-
valuable information to better select the appropriate fication of the prominent microorganisms in the cul-
antibiotic regimen. For example, an immunocompro- ture. With persistent infections, susceptibility testing
mised/immunosuppressed patient (not immunocom- can be undertaken to establish which antibiotics are the
petent) or patients at high risk of developing an infec- most effective against resistant microbial isolates. At
tion (eg, history of infective endocarditis) following a present, it may take 1 to 2 weeks to identify anaerobes.
bacteremia require close monitoring. These patients In the future, molecular methods will be used to rapid-
may have an infection caused by bacteria usually not ly detect and identify known opportunistic bacteria.
associated with the oral cavity. Other examples include
a seemingly healthy patient who has persistent or pro- ROOT CANAL DBRIDEMENT AND
gressive symptoms following surgical or nonsurgical INTRACANAL MEDICATION
endodontic treatment. The goal of clinical treatment is to completely disrupt
An aseptic microbial sample from a root canal is and destroy the bacteria involved in the endodontic
accomplished by first isolating the tooth with a rubber infection. Endodontic disease will persist until the
dam and disinfecting the tooth surface and rubber source of the irritation is removed. The microbial
dam with sodium hypochlorite or other disinfectant. ecosystem in an infected root canal has been directly
Sterile burs and instruments must be used to gain linked to both acute and chronic inflammation.31,138
access to the root canal system. Antimicrobial solu-
tions should not be used until after the microbial sam- Root Canal Dbridement
ple has been taken. If there is drainage from the canal, Root canal dbridement includes the removal of the
it may be sampled with a sterile paper point or aspi- microorganisms and their substrates required for
rated into a syringe with a sterile 18- to 25-gauge nee- growth. Chemomechanical cleaning and shaping of the
dle. Any aspirated air should be vented from the root canal system remove a great deal of the irritants, but
syringe into a sterile gauze. The aspirate should either total dbridement is impeded because of the complex
be taken immediately to a microbiology laboratory in root canal systems with accessory canals, fins, cul-de-
the syringe or injected into pre-reduced transport sacs, and communications between the main canals. The
media. To sample a dry root canal, a sterile syringe last decade has seen the development and use of several
should be used to place some pre-reduced transport innovative methods and materials to aid in root canal
medium into the canal. A sterile endodontic instru- dbridement. The ability of nickel-titanium instruments
ment is then used to scrape the walls of the canal to to remain centered in canals has facilitated the use of the
suspend microorganisms in the medium. step-down method of instrumentation without signifi-
To prevent contamination by normal oral flora, a cant concern for ledge formation or canal transporta-
microbial sample from a soft tissue swelling should be tion.148,149 In addition, the step-down method removes
obtained before making an incision for drainage. Once debris as progress is made toward the apex, so irritating
profound anesthesia is achieved, the surface of the debris is not carried apically and extruded into the peri-
mucosa should be dried and disinfected with an apical tissues.150 The step-down method also enlarges
iodophor swab (The Purdue Frederick Company, the coronal portions of the canal so that there is a larger
Norwalk, Conn.). A sterile 16- to 20-gauge needle is reservoir for an irrigant. Numerous irrigants have been
then used to aspirate the exudate. The aspirate should used and studied, but sodium hypochlorite (0.5 to
then be handled as described above. If purulence can- 5.25%) remains the most popular irrigant in the United
not be aspirated, a sample can be collected on a swab States. Sodium hypochlorite, in concentrations of 0.5 to
after the incision for drainage has been made, but great 5.25%, has the ability to dissolve organic pulpal debris in
care must be taken to prevent microbial contamination areas not reached by endodontic instruments.151155 It is
with normal oral flora. After collecting the specimen also an excellent antimicrobial.73,75,156
When sodium hypochlorite is alternated as an irrig- In the past, numerous antimicrobial agents have
ant with 15% ethylenediaminetetraacetic acid (EDTA), been used that were antigenic and cytotoxic and pro-
both the instrumented and the noninstrumented sur- vided relatively short-term antisepsis.171175 These
faces of a root canal are chemically dbrided.157 included traditional phenolic and fixative agents such
Sodium hypochlorite reacts with organic tissue to facil- as camphorated monochlorophenol, formocresol,
itate cleaning; however, this reaction inactivates the eugenol, metacresylacetate, and halides (iodine-potas-
agent and decreases its antibacterial capacity. Thus the sium iodide). A reliance on mechanical instrumenta-
irrigant in the canal should be frequently replenished tion and aversion to the use of cytotoxic chemicals have
to maintain the most optimum activity of sodium led to a lack of use of an intracanal dressing by many
hypochlorite. Both 0.5% and 5% sodium hypochlorite clinicians, a practice that allows remaining bacteria to
have been shown to be effective antimicrobials in clin- multiply between appointments.
ical studies.158,159 However, 5% sodium hypochlorite is The current intracanal dressing of choice is calcium
more effective than 0.5 sodium hypochlorite as a sol- hydroxide. Although not characterized as an antiseptic,
vent of necrotic tissue.160 Research has shown that the studies have shown calcium hydroxide to be an effective
combined use of 15% EDTA and 5.25% sodium antimicrobial agent.158,176180 Other studies have shown
hypochlorite was more efficient as an antimicrobial it to be an effective interappointment dressing over sever-
than 5.25% NaOCl by itself for irrigating infected root al weeks.181,182 When mixed into a paste with water, cal-
canals.158 The irrigants must be passively introduced cium hydroxides solubility is less than 0.2%, with a pH of
into the canal without wedging the needle and inadver- about 12.5. Some of its antibacterial activity may be relat-
tently infusing the irrigant into the periapical tissues, ed to the absorption of carbon dioxide that starves
where they will produce pain and tissue injury.161,162 capnophilic bacteria in the root canal.183 The Saunders
Use of a needle with a slot at the tip or side opening group in Dundee was disappointed, however, in the lack
helps to prevent wedging of the needle. Sonic and of antibacterial activity of calcium hydroxide against the
ultrasonic devices may be used to improve the efficacy anaerobes P. gingivalis and Peptostreptococcus micros.184
of irrigation.163167 On the other hand, calcium hydroxide has been
shown to hydrolyze the lipid moiety of bacterial
Intracanal Antisepsis lipopolysaccharides, making them incapable of pro-
Residual microorganisms left in the root canal system ducing such biologic effects as toxicity, pyrogenicity,
following cleaning and shaping or microbial contami- macrophage activation, and complement activation.177
nation of a root canal system between appointments Lipopolysaccharides have been shown to be present in
have been a concern. If root canal treatment is not the dentinal tubules of infected root canals.18,185
completed in a single appointment, antimicrobial Obliterating the canal space with calcium hydroxide,
agents are recommended for intracanal antisepsis to during treatment, may minimize the ingress of tissue
prevent the growth of microorganisms between fluid used as a nutrient by microorganisms.186 Removal
appointments. The access opening in the tooth must of the smear layer facilitates the diffusion of calcium
also be sealed with an effective interappointment filling hydroxide into the dentinal tubules.187 But smear layer
to prevent microbial contamination by microleakage or not, a Brazilian group was disappointed in the
from the oral cavity. Despite the controversy over cul- inability of calcium hydroxide to destroy bacteria in
turing root canals, most clinicians agree that healing is infected dentinal tubules,188 whereas four root canal
more likely in the absence of bacteria.168170 sealers appeared to be quite effective against tubuli bac-
A recent study used modern microbiologic tech- teria, AH-26 being the best.189 Moreover, zinc
niques, with teeth root-filled at a single appointment oxideeugenol sealer was found to be more effective in
and evaluated for clinical success.76 Initially, all 55 sin- inhibiting the growth of Streptococcus anginosus than
gle-rooted teeth were infected. After instrumentation three of the calcium hydroxidecontaining sealers.190
and irrigation with 0.5% sodium hypochlorite, bacteria Actinomyces israelii, a species of bacteria isolated
could still be cultivated from 22 of the 55 root canals. from periapical tissues, has been reported to not
Periapical healing was followed for up to 5 years. respond to conventional endodontic therapy.63,191,192
Complete healing occurred in 94% of those teeth that Recently, however, both sodium hypochlorite and calci-
had negative cultures but only 68% of those with posi- um hydroxide have been shown to be highly effective in
tive cultures at the time of root canal obturation.76 killing A. israelii.193 The optimal treatment of periapi-
These findings suggest the importance of eliminating cal actinomycosis is endodontic surgery that removes
bacteria from the root canal system before obturation. the likely cause, enables microscopic confirmation, and
has a high chance of success without prescribing antibi- identified risks to health care professionals has
otics.63,191,193 In classic forms of actinomycosis involv- increased tremendously. The Occupational Safety and
ing invasion and spread of A. israelii in the periradicu- Health Administration (OSHA) regulations have had a
lar tissues, antibiotic treatment is justified. When actin- profound impact on the practice of dentistry.
omycosis cannot be controlled by surgery, antibiotic Traditionally, hepatitis B has been the benchmark dis-
therapy is justified and optimized by prescribing for an ease on which infection control has been based.205 In an
extended period of 6 weeks with amoxicillin or office that treats approximately 20 patients per day, the
cephalexin.193 personnel can expect to encounter 1 active carrier of
Calcium hydroxide has been shown to have some hepatitis B virus (HBV) every 7 working days. In addi-
efficacy in the dissolution of pulp tissue in vitro and tion, one can expect exposure to 2 patients with oral her-
may increase the ability of sodium hypochlorite to dis- pes and an unknown number of patients infected with
solve remaining organic tissue at subsequent appoint- human immunodeficiency virus (HIV). It is generally
ments.160,194 The tissue-dissolving property seems to accepted that the potential for HBV transmission in the
work equally well in aerobic and anaerobic environ- dental environment is greater than that for HIV.210
ments.195 Some commercial preparations of calcium Immediate exposure is one critical factor, but HBV and
hydroxide come packaged in syringes, or the powder tubercle bacilli have been shown to survive on inanimate
may be mixed with water or glycerin to form a thick surfaces beyond 7 days, thus illustrating the longevity of
paste. The paste is carried into the pulp chamber with the pathogens. Hepatitis B virus is also highly infectious,
a plastic instrument, amalgam carrier, or syringe and with as little as 0.00001 mL of contaminated blood capa-
then carried down the canals using a lentulo, prefitted ble of transmitting the disease. Human immunodefi-
pluggers, or counterclockwise rotation of endodontic ciency virus has been recovered from 1 to 3 days after
files. Calcium hydroxide is easily removed from the drying under certain conditions.211
canal system at the next appointment using endodon- Human immunodeficiency virus and HBV infec-
tic files and irrigation. tions have raised the concern of the profession and the
When exposed to carbon dioxide in an open con- public alike. Health care workers worry about acquir-
tainer, some calcium hydroxide is slowly converted into ing HIV from patients, and patients worry about being
inactive calcium carbonate. In a closed container, it is exposed to diseases in dental offices. Much attention
quite stable, with only 1 to 2% being converted after has been aroused by the highly publicized case in
several months.196 A good temporary filling that is sev- Florida in which a dentist may have infected at least five
eral millimeters thick to prevent microleakage is impor- of his patients before he himself died from acquired
tant between appointments.197201 Calcium hydroxide immune deficiency syndrome (AIDS).212
has also been shown to decrease the amount of micro- The transmission route of HIV/HBV in this two-way
bial contamination under temporary fillings.202 street is primarily through the exchange of blood.
Another root canal medicament has more recently Percutaneous injury to dentists is the most direct
been introduced in Germany, a liquid medication known patient-to-dentist transmission method. Infected den-
as camphorated chloroxylenol (ED84), which is claimed tists, in turn, can then unknowingly infect other
to be as effective as a temporary root canal dressing for a patients.213
duration of 2 days and to be nontoxic to tissue.203 Percutaneous injuries to dentists are caused by burs
(37%), syringe needles (30%), sharp instruments (21%),
ASEPSIS IN ENDODONTIC PRACTICE orthodontic wires (6%), suture needles (3%), scalpel
Endodontics has long emphasized the importance of blades (1%), and other objects (2%). In recent years,
aseptic techniques using sterilized instruments, disin- however, needlestick injuries have dropped dramatically.
fecting solutions such as sodium hypochlorite, and Oral surgeons suffer the highest percutaneous injury
rubber dam barriers. In the past decade, numerous rate and endodontists the lowest. The average dentist
articles have been written regarding the exposure of performs about 3,000 invasive procedures a year37%
dental personnel to infectious diseases.204209 In 1979, of all procedures. The percutaneous injury rate ranges
Crawford discussed guidelines for contamination con- from 3.16 (general practice) to 3.43 (specialties)
trol with respect to sterilization and disinfection in sticks per year, any one of which could be disas-
endodontic practice.204 More recently, further recom- trous.213 Proper sterilization and infection control pro-
mendations have been made to prevent transmission of cedures in dental offices have become important issues
infectious diseases.205209 Interestingly, the basic tenets for the public, the dental profession, and government
still apply today, but with many additions. The list of agencies such as OSHA.
8. Medical solid waste: Empty specimen containers, ties, and a host of other physical limitations that may
bandages or dressings containing nonliquid blood, require special attention. Consultation with attending
surgical gloves, treated biohazardous waste, and physicians is most important in proper care of such
other materials that are not biohazardous.214 patients.
PATIENT EVALUATION CLASSIFICATION OF INSTRUMENT
The identification of patients with transmissible dis- STERILIZATION
eases and of those belonging to high-risk groups is Spauldings classification for instruments has been
essential before treatment begins.205,207,208,215 The Ad cited as a methodology for instrument sterilization.217
Hoc Committee on Infectious Diseases of the The categorization of instruments depends on the con-
American Association of Public Health Dentists has tact with different tissue types to determine whether
listed diseases of concern to dental personnel207 (Table sterilization or disinfection is required. The categories
3-5). Populations at high risk of contracting hepatitis B are as follows:
are listed in Table 3-6. According to the Centers for
1. Critical items: Instruments that touch sterile areas of
Disease Control and Prevention (CDC), however,
the body or enter the vascular system and those that
because the medical history and examination cannot
penetrate the oral mucosa. Examples are scalpels,
reliably identify all patients with bloodborne
curettes, burs, and files. Because of their potential for
pathogens, blood and body fluid precautions should be
harboring microorganisms, dental handpieces also
consistently used for all patients.210 The concept stress-
must be sterilized.218 Instruments in this category
es that all patients should be assumed to be infectious
for HIV and other bloodborne pathogens.216
Unfortunately, the medical history is only an adjunct to
the patients background and cannot be considered a
Table 3-6 Groups at High Risk of Contracting
totally inclusive source of information.
Hepatitis B
In the daily practice of endodontics, one must fre-
quently re-evaluate the patients medical history, at Health care personnel
least on a yearly basis. With the recent advances in the Selected patients and patient contacts
treatment of medically compromised patients, a greater Patients and staff in hemodialysis units and hematology/
number of patients will enter the office with immuno- oncology units
compromised conditions, cardiovascular susceptibili- Patients requiring frequent or large-volume blood trans-
fusions or clotting factors (ie, hemophiliac patients)
Residents and staff of institutions for the mentally hand-
Table 3-5 Transmissible Diseases of Concern to icapped
Dental Providers Household and sexual contacts of persons with persistent
hepatitis B antigen
Hepatitis (types A, B, non-A/non-B) (hepatitis B virus)
Newborns of hepatitis B surface antigen carrier mother
Acquired immune deficiency syndrome (human
immunodeficiency virus) Populations with high incidence of the disease
Syphilis Alaskan natives
Gonorrhea Indo-Chinese refugees
Influenzas Haitian refugees
Acute pharyngitis (viral or streptococcal) Native Pacific Islanders
Pneumonias Sub-Saharan Africans
Tuberculosis Morticians and embalmers
Herpes Blood bank and plasma fractionation workers
Chickenpox Persons at increased risk of disease because of sexual practices
Infectious mononucleosis
Prisoners
Rubella
Rubeola Users of illicit injectable drugs
Mumps International travelers
Reproduced with permission from the Ad Hoc Committee on Reproduced with permission from the Ad Hoc Committee on
Infectious Diseases.207 Infectious Diseases.207
must be sterilized and stored in appropriate pack- ber are also sensitive to heat and moisture and cannot
ages. Single-use items must be properly discarded. be placed in the autoclave.
2. Semicritical items: Instruments that touch mucous
membranes but do not penetrate tissues. This Chemical Vapor SterilizationChemclave
includes amalgam condensers and saliva ejectors. This method is based on the factors of heat, water, and
These items should be sterilized; however, if this is chemical synergism. The chemicals include alcohol,
not feasible, high-level disinfection or disposal is acetone, ketones, and formaldehyde. The water content
required. is below the 15% level, above which rust, corrosion,
3. Noncritical items: Those items that do not come in and dullness of metal occur. The composition of heat
contact with oral mucosa but are touched by saliva- and chemicals is much kinder to metal surfaces than
or blood-contaminated hands while treating are other techniques. The temperature requirements
patients. Such items include light switches, counter- are 132C (270F) for 20 minutes. The main advantages
tops, and drawer pulls on cabinets. These areas are the fast turnaround time and the protection of car-
should be properly disinfected. bon steel instruments. The main disadvantage is the
odor that is released when the chemicals are heated.
STERILIZATION This method has become a popular mode of steriliza-
A recent Minnesota study suggests that approximately tion in endodontic offices.
one of every five efforts at instrument sterilization in
dental offices fails. Errors made by the sterilizer opera- Dry Heat Sterilization
tor were found to be the major cause of failure.212 This technique of sterilization requires a temperature
Four elements essential to ensuring proper steriliza- of 160C (320F) for 2 hours. The primary disadvan-
tion are recommended: tage of this technique is the long sterilization time.
Initial cost of the dry heat method is lower than that of
1. High-quality sterilization equipment and mainte-
the two previously described. During the loading
nance
process, instruments must be separated to prevent the
2. Correct operation of sterilization equipment
creation of air pockets (stratification) leading to inef-
3. Comprehensive operator training
fective sterilization. Some units also have problems of
4. Weekly use of biologic indicators (Bacillus subtilis
uneven heating.
strips) to monitor sterilization effectiveness.212
Recently, a Rapid Heat-Transfer Sterilizer was intro-
The four methods of sterilization that are generally duced as the Cox sterilizer (Alfa Medical Equipment
accepted in dentistry include steam under pressure, Co.; Hempstead, N.Y.). Operated at 190C, it will, by
chemical vapor, dry heat sterilization, and glutaralde- rapid airflow, sterilize unpackaged instruments in 6
hyde solutions.208,219 Ethylene oxide gas, ultraviolet minutes and packaged instruments in 12 minutes.
light, microwave, and other forms of radiation are effec-
tive but have limited use in dentistry at present.217,220 Preparation for Sterilization
Glutaraldehyde solutions are reviewed with disinfec- Instruments and equipment intended for sterilization
tants because of difficulties of attaining sterilization or disinfection procedures must first be carefully pre-
using the medium. pared. This precleaning is essential to remove blood,
saliva, tissue, and other debris that can interfere with
Steam Under PressureAutoclaving the sterilization process. The instruments should be
The commonly accepted criteria for autoclaving are cleaned thoroughly by scrubbing with soap and water
121C (249F) at 15 psi for 15 to 40 minutes. The time or a detergent solution, or with a mechanical device
depends on the items to be autoclaved, the size of the (ultrasonic cleaner). The use of a covered ultrasonic
load, and the type of container used. Included in this cleaner is an effective method of increasing the effi-
method is the flash sterilization technique, for which ciency of cleaning and reducing the handling of sharp
shorter times with higher temperatures are used. There instruments.
is, however, a greater chance for sterilization error to When it is not possible to clean and process instru-
occur. The disadvantages of autoclaving include rust- ments immediately after their use, they may be held in
ing, corroding, and dulling of instruments, especially a holding solution to prevent organic material from
those composed of carbon steel. Instruments removed drying on them, making them difficult to clean. Water,
from the chamber are wet, which increases the turn- a detergent solution, or an intermediate-level disinfec-
around time of sterilization. Certain plastics and rub- tant may be used for this purpose.
tilled water. Hard water inactivates the iodophor. check-valves showed significant decreases in the
Biocidal activity occurs within 30 minutes. amount of bacteria in the dental units with check
Iodophors also have a built-in color indicator. When valves.225 Microorganisms, however, were still found
the solution is fresh, an amber color is present. With even in units using the check-valve. Eliminating the
age, the solution changes to light yellow, indicating the fluid retraction valve was the most effective way to
loss of the iodophor molecules. A mixture of iodophor prevent fluid retraction, but then water continued to
with alcohol was thought to enhance the activity, but drip from the units. The CDC recommends that
research evidence is insufficient to support this handpieces be flushed for 20 to 30 seconds between
claim.222 The iodophor compound is to be used solely patients and for several minutes at the beginning of
as a disinfectant. The sporicidal capabilities of the sub- each day to reduce any overnight bacterial accumu-
stance have not been shown. lation in the units. They also recommend that sterile
saline or sterile water be used as a coolant/irrigant
Alcohols for any surgical procedures.226
Alcohols are not accepted by the ADA for disinfection
of surfaces or instruments. BARRIER TECHNIQUES
Three factors determine whether disease develops in
Quarternary Ammonium Compounds the host after exposure: virulence of the disease agent,
This group of compounds, including benzalkonium chlo- resistance of the host, and the quantity of the disease
ride, is no longer recommended for instrument or surface agent.227 Barrier techniques in infection control
disinfection. All quarternary ammonium compounds address the quantity factor in disease prevention. This
have been disapproved by the ADA for use in dentistry. may encompass protection of the body surfaces, pro-
tection of the environmental surfaces, or blockage of
DISINFECTION TECHNIQUES bacteria from the source.
The following disinfection techniques are recommended
by the ADA and The Center For Disease Control: Gloves
Gloves provide the patient with protection from contam-
1. Immersion disinfection: Solutions must be fresh and ination of microorganisms on the practitioners hands
changed according to manufacturers recommenda- and protect dental health care workers from contamina-
tions. All instruments must be cleaned by thorough tion by the patients blood and saliva.227 Small cuts and
scrubbing with soap and water or with a mechanical abrasions on the hands can serve as portals of entry into
cleaner, such as an ultrasonic unit. Heavy-duty rubber the body. Gloves can provide a barrier between open
gloves should be worn during instrument decontam- wounds and bacteria from blood and saliva. In one
ination. Instruments must be dried before being research study, traces of blood were found beneath the
placed in the disinfectant to prevent dilution. fingernails of 44% of ungloved general dentists.228
2. Surface disinfection: Countertops and surfaces that One of the main concerns about the use of gloves
have become contaminated with blood, saliva, and has been the worry about possible loss of tactile sense,
debris must be wiped and/or scrubbed to remove especially in the practice of endodontics. In a study
organic material after being sprayed with an appro- focusing on tactile sense, no significant differences
priate surface disinfectant. Once cleaned, the surface were found among gloved versus ungloved clini-
is again sprayed and left moist for the recommend- cians.229 In a time test of endodontic performance, no
ed period. Surface decontamination is approximate- differences were found between gloved and ungloved
ly 80% effective in bacterial control.205 hands.230 The difficulty lies in the fact that many clini-
3. Decontamination of dental units: Dental units have cians were trained when gloves were not used. Studies
come under scrutiny in the environment of infec- have shown that learning periods of 1 to 2 months are
tion control. Check-valves have been recommended necessary to become accustomed to wearing gloves.231
to prevent aspiration of infective materials into Proper fit is important for tactile control and comfort.
handpieces and water lines.208 A major implication Gloves vary in size between manufacturers and even
would be if a patient were infected with HBV, HIV, within the same brand, depending on the type of glove
or tuberculosis and these organisms were aspirated (ie, examination versus surgical).
into the unit and allowed to colonize. They could The reuse of gloves has been reviewed by many
later be discharged into the mouths of subsequent authors.208,231,232 Gobetti and associates have stated that
patients. A comparison of units with and without washing a gloved hand removed significant amounts of
bacteria.233 If iodine scrub soap was used, the gloved ommended during procedures that result in splashing
hand would be free of bacteria. In a study of the evalua- blood or other body fluids. Gowns should be changed
tion of gloves, pinholes occurred randomly and were at least daily. Laundering can be effectively accom-
independent of the type or manufacturer.231 Pinholes plished with a high-temperature (60 to 70C) wash
occurred in 1.7 to 9% of the gloves tested. Tear strength cycle with normal bleach, followed by machine drying
also varied. The investigators did not recommend reuse (100C or more). According to the CDC reports, this
after conventional dental procedures because the clini- method, along with dry cleaning and steam pressing, is
cian had no way to determine the integrity of the glove. effective in killing the AIDS virus.234 Shoes should be
The ADA Council on Dental Therapeutics and the changed at the office or kept out of reach of small chil-
CDC recommend that gloves not be reused.234 Double dren at home because they are in constant contact with
gloves may be indicated for patients with known infec- saliva and blood splatter that settle on the floor.
tious diseases, such as herpes, HBV, and HIV. Gloves
that are known to have been contaminated with an Procedural Barriers
infectious entity (ie, HBV, HIV) should be sterilized The rubber dam has been shown to be an effective bar-
before being discarded.234 rier to reduce the number of organisms contained in
aerosols.227 The number of infectious particles can be
Hand Washing reduced by 99%. The rubber dam prevents aerosoliza-
Hands should be washed before gloves are placed and tion of saliva and should be used whenever possible.
after gloves are removed because the integrity of the Operating fields, isolated by a rubber dam, however,
glove is not dependable.208 Antimicrobial hand-wash- showed bacterial contamination in 53% of the cases
ing solutions should be used.209 If, during the course of after 1 hour.235 When silicone and adhesives were used
treatment, a glove is torn, the glove should be removed to further seal around the dam, bacterial leakage was
and the hands washed and then regloved. reduced to 20%.
Although high-speed evacuation is not a true form
Face Masks of barrier control, it should be used whenever possible.
The face mask is an important barrier providing pro- Evacuation decreases the amount of particles that
tection from inhalation of aerosols generated by become airborne.208
high-speed handpieces and air-water syringes. The Disposable impervious-backed paper, plastic, or alu-
mask should remain dry to prevent transmission of minum wrap can be used to cover surfaces and opera-
organisms through moisture penetration. Masks may tory equipment.208,227 This aids in the prevention of
be composed of glass or synthetic fiber, paper, or gauze. surface contamination from blood or saliva. Plastic is
The fiber-type mask is considered to be more efficient more resistant to water penetration and can be molded
in filtering bacteria.228 Masks should be worn by all into any shape more easily than can paper. Specially
treatment personnel and should be changed between designed covers are commercially available to protect
patients because masks worn for prolonged periods light handles, chairs, and bracket and instrument
may become a nidus of infection. tables. Ash et al. developed a technique wherein radi-
ographic film can be wrapped and sealed with a plastic
Eyeglasses to prevent contamination with saliva.236 After the film
Protective eyewear is highly beneficial for dental care has been exposed, the wrap is opened and the film
providers and for the patient. Herpes virus infection of handed to someone who is not contaminated and
the eye and infection from hepatitis B are possible con- therefore can then develop the saliva-free film. Another
sequences of viral contact with the eye.227 Eyewear can method is to open the contaminated film packet in the
prevent bacterial or viral contact with the eye by darkroom or developing box using disposable gloves.
aerosol spray or droplet infection. Chin-length face The films should be dropped out of the packets with-
shields are also effective in the prevention of splashing out touching the films. Drop the contaminated packets
and splattering of blood and saliva; however, they do in a paper cup. After all packets have thus been opened,
not provide protection from inhalation of aerosols. the discarded packets and the gloves can be removed
before processing the films. A recent study has demon-
Clothing strated that bacterial contamination on radiographic
The general recommendations for clinic wear include films can survive the processing, thus pointing out the
reusable or disposable gowns and laboratory coats or importance of preventing cross-contamination for this
uniforms with long sleeves. Head covers are also rec- dental procedure.237
Figure 3-10 Infection control for the dental office: a checklist. (Report, Council on Dental Materials, ADA.209)[may be copied]
tion. Recommendations from federal, state, and local 22. Sundqvist G, Carlsson J, Herrmann B, Trnvik A. Degradation
authorities can change frequently; therefore, one must of human immunoglobulins G and M and complement
factors C3 and C5 by black-pigmented Bacteroides. J Med
remain constantly updated on current information.
Microbiol 1985;19:85.
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Chapter 4
PULPAL PATHOLOGY:
ITS ETIOLOGY AND PREVENTION
John I. Ingle, James H. S. Simon, Richard E. Walton, David H. Pashley,
Leif K. Bakland, Geoffrey S. Heithersay, and Harold R. Stanley
4. Cavity liners
5. Dentin bonding agents
6. Tubule blockage agents
B. Disinfectants
1. Silver nitrate
2. Phenol
3. Sodium fluoride
C. Desiccants
1. Alcohol
2. Ether
3. Others
V. Idiopathic
A. Aging
B. Internal resorption
C. External resorption
D. Hereditary hypophosphatemia
E. Sickle cell anemia
F. Herpes zoster infection
G. Human immunodeficiency virus (HIV) and
acquired immune deficiency syndrome (AIDS)
BACTERIAL CAUSES
Coronal Ingress
Caries. Coronal caries is by far the most common
means of ingress to the dental pulp for infecting bacte-
ria and/or their toxins (Figure 4-1). Long before the
bacteria reach the pulp to actually infect it, the pulp
becomes inflamed from irritation by preceding bacter-
ial toxins. Langeland reported pulp reactions he
observed with certainty when superficial enamel fis-
Figure 4-1 Bacteria penetrating through dentinal tubules from
sure caries were found clinically1 (Figure 4-2). carious lesion (top). Pulp inflammation is already established from
Brnnstrm and Lind observed inflammatory changes toxins that precede bacteria (Orban collection).
in the pulps of 50 of 74 premolars with initial enamel
caries on proximal surfaces but with no radiographic
evidence of penetration2 (Figure 4-3).
Brnnstrm and his associates also demonstrated under moderately developed caries, to frank chronic
the alarming rapidity with which bacteria penetrate the inflammatory exudate under deep carious lesions.5
enamel.3 From incipient carious lesions, without cavi- Skogedal and Tronstad remarked on how reasonable
tation on the enamel surface (Figure 4-4), microorgan- it is to expect pulp involvement subjacent to carious
isms can reach the dentinoenamel junction. The ensu- lesions in the dentin because of the intimate relation-
ing gap between the enamel and dentin completely fills ship between the dentin and the dental pulp.6 They
with microorganisms. The infection is then shown to pointed out, however, the existing disagreement over
spread not only laterally along the dentinoenamel junc- attempts by some to correlate the degree of inflamma-
tion but pulpally as well. It is quite conceivable that a tion with the depth and virulence of the carious
degree of pulp inflammation could develop well before lesion. It is conceivable, they surmised, that the
a visual or radiographic break in the enamel becomes apparent discrepanciesare due to variations in the
apparent. To compound the problem, Douglass et al. reaction known to occur in the dentin subjacent to car-
have claimed that only 60% of dental caries lesions can ious lesions. This is discussed later in the chapter.
be detected by radiographs alone.4 Most of the evidence to build and solve this enigma
Seltzer et al. have described these pulp changes, from has been provided by Scandinavian researchers.
early irritation dentin formation under initial caries, Bergenholtz and Lindhe produced severe pulpitis with
through scattered macrophages and lymphocytes necrosis, within hours, merely by sealing an extract of
A B
Figure 4-2 Enamel fissure caries leading to dentin and pulp involvement. A, At the top center, there is no break at the dentinoenamel junc-
tion, yet bacteria (upper arrow) have already penetrated dentin, and their toxins have caused pulp reaction (lower left arrow). Note break in
the odontoblast layer and subjacent inflammatory cells. B, Bacteria in tubuli just below carious surface. (Courtesy of Dr. Karre Langeland.)
human dental plaque into deep class V cavity prepara- that the rapidity and degree of flow of noxious stimuli
tions7 (Figure 4-5). Years before, Langeland achieved a toward the pulp are directly related to the absence or
similar result by sealing soft carious dentin into a pre- presence of a dense dentin barrier.11 Thus, the most
pared cavity.8 Langelands seminal research was con- permeable would be dead tract dentin (empty tubules)
firmed by Mjr and Tronstad, who also compared the followed by primary dentin (Figure 4-9). Irritation
pulp reaction to carious dentin sealed into prepara- dentin, on the other hand, should be considerably less
tions in intact teeth against a control of gutta-percha permeable (Figure 4-10).
temporaries9 (Figure 4-6 to 4-8). The supposition can be made, therefore, that the
Dentin Permeability. One might assume from acuteness or chronicity of caries as a disease serves to
these studies that normal primary dentin is incapable stimulate the production of an effective irritation
of protecting the pulp from toxic agents or immune dentin barrier. The highly acute lesion evidently over-
reactions triggered by the microorganisms of dental whelms the pulps calcific defense capability, whereas
plaque or soft carious dentin. The speed with which the chronic lesion allows time for an irritation and scle-
pulp reactions take place is obviously related to the rotic dentin defense to develop. This could well explain
amount and degree of calcification of the remaining the variance from normal pulp to advanced pulpitis
dentin. Reeves and Stanley found little inflammation if under large carious lesions.
bacteria penetrated to within 1.1 mm (including irrita- Reversible or Irreversible Pulpitis. Thus far in this
tion dentin) of the pulp.10 Pathosis increased, however, chapter, nothing has been said about the pulp, which
when the lesion reached to within 0.5 mm of the pulp, has been considered inflamed rather than infected.
and abscess formation developed when the irritation Here again, controversy develops: Does the inflamed
dentin barrier was breached. and/or infected pulp represent reversible or irreversible
For the remaining dentin to act as a barrier, it is pulpitis? What allows microorganisms to finally pene-
important to consider both dentin thickness and the trate the dentin and invade and infect the pulp? Why is
degree of mineralization. Trowbridge made the point their movement relatively slow in the dentin yet
B C
Figure 4-4 Round and rod-shaped microorganisms found Figure 4-5 Localized abscess formation (arrows) subjacent to
between enamel prisms on the surface of a dull white-spot lesion. dentin cavity (C) after 32 hours of microbial provocation with
Bacteria extend to the dentinoenamel junction. Reproduced with lyophilized components from dental plaque bacteria. Reproduced
permission from Brnnstrm M.3 with permission from Bergenholtz G.345
A B
Figure 4-6 A, Histologic pulp changes defined as slight. Cavity (C) restored with gutta-percha for 8 days.
B, Higher magnification of area subjacent to the cavity. A slight increase in cellularity results in obscuring of
cell-free zone. Slight increase in capillaries. Reproduced with permission from Mjr IA and Tronstad L.9
A B
Figure 4-7 A, Histologic pulp changes defined as moderate. Cavity (C) left open for 8 days. B, Higher magnification of area subjacent to
the cavity. Increased cellularity and disruption of odontoblastic layer with some odontoblast nuclei displaced into dentin tubules. Increase in
vascularity. Reproduced with permission from Mjr IA and Tronstad L.9
A B
Figure 4-8 A, Histologic pulp changes defined as severe. Cavity (C) filled with soft, carious human dentin for 8 days. B, Higher magnifica-
tion of area subjacent to cavity. Marked cellular infiltration and necrosis, odontoblast layer also destroyed, and predentin missing.
Reproduced with permission from Mjr IA and Tronstad L.9
One could summarize, therefore, that unetched Bergenholtz and Lindhe seemed to think so: A
dentin, while permitting fluid filtration, restricts bacte- moderate to severe inflammatory pulpal reaction may
rial penetration.23 Hence the noxious filtrates from heal if the irritating agents are removed from the
the carious lesion or dental plaque can penetrate into dentin [emphasis added]. Healing of a localized pulp
the tubules (where the odontoblast cell body is affect- reaction (abscess formation) may occur not only when
ed) and into the pulp, where inflammation rapidly the irritating agents are removed from the dentin, but
develops. The bacteria, on the other hand, being gross- also more important, healing may occur even with con-
ly larger than the filtrate, cannot pass the calcific struc- stant bacterial irritation of dentin.7
tures or the microcrystalline tubular debris unless pre- Bergenholtz and Lindhe had this histologic insight
ceded by an acid (which they produce) that decalcifies after removing dental plaque constituents from sealed
the dentin while clearing and widening the tubules. class V preparations after 32 hours (see Figure 4-5) at 4,
The slowness with which dentin demineralization 10, or 30 days and substituting zinc oxideeugenol
and subsequent bacterial transport occur is related to (ZOE) cement.7 They further surmised that irritation
the higher organic content of dentin. Enamel, on the dentin, accompanying sudden (within 32 hours) bacte-
other hand, being highly inorganic, is demineralized rial irritation, should be regarded as a scar tissue that
readily (witness the total loss of enamel in histologic develops after or along with the healing process of the
sections) by the bacteria, thus allowing an easier path- pulp.7 However, there was also evidence contrary to the
way for bacterial movement through enamel as noted healing process. In other cases, Bergenholtz and Lindhe
by Brnnstrm et al.3 found that an acute inflammatory reaction of the den-
In the end, Masslers and MacGregors13,14 affected, tal pulp can result in total necrosis of pulp tissue7
decalcified leathery dentin might well provide the bacte- Lervik and Mjr also noted healing in inflamed
rial pathway for pulp invasion and infection. Whether pulps after 7 to 8 days.29 In a series of experiments in
the ensuing pulpitis is reversible or irreversible is still which they induced pulp inflammation within 2 to 3
open to question. It is quite possibly reversible if the bac- days by sealing soft carious dentin into cavity prepara-
teria have not yet reached the pulp and quite possibly tions of intact teeth, they found that healing had begun
irreversible if the pulp has become infected by bacteria.1 7 to 8 days later in the form of increased predentin for-
Pulpal Healing. Bacteria are an obvious formida- mation. They were struck by the quality of the irrita-
ble enemy of the pulp, but possibly not so formidable tion dentin effort to establish a barrier against further
as once supposed. In a review of the clinical manage- noxious stimuli. Very irregular irritation dentin
ment of the deep carious lesion, Canby and Burnett formed in one of their experimental teeth, which
discussed the wisdom of not exposing the pulp under became necrotic after 82 days. Successful healing, on
deep caries: Removing all carious dentin and jeopard- the other hand, was marked by quite regular dentin
izing a vital pulp with no significant untoward history formation.29
or reaction [emphasis added] would seem to be a ques- Langeland et al., in marked contrast, have long felt
tionable method and a needless contribution to the atubular dentin to be less permeable and that pulp
complexity of treatment25 inflammation is readily found subjacent to atubular
This approach is also borne out by Muntz et al.26 and tubular dentin.30
and by Seltzer et al.,27 who predicted the possibility of It has been pointed out that irregular, or basically
pulp recovery if its ability to produce irritation dentin atubular, dentin results from destruction of the
keeps ahead of the carious process. This could well involved odontoblastic processes and the entire odon-
happen. Irritation dentin is formed in monkey teeth at toblasts and that the cells immediately subjacent to
a rate of 2.9 m per day, over three times the rate of the reparative dentin more closely resemble fibroblasts
secondary dentin, of which 0.8 m is laid down daily.28 than the original odontoblasts. Regular (tubular)
The healing capacity of the pulp, inflamed by bacte- dentin, on the other hand, derives from uninjured or
rial toxins or bacteria per se, is still in dispute. As stated newly formed odontoblasts. It is further stated that
above, the pulp may well be able to keep ahead of repair of dentin is in no way indicative of the repair of
chronic caries by constantly laying down irritation or the pulpal connective tissue and that pulp repair can
sclerotic dentin while receding from the irritant to lick never be complete as long as chronic inflammation is
its wounds, so to speak. But acute caries is another present: In fact, it may be this chronic subclinical pul-
matter. If pulp inflammation begins within hours of pitis that results in acute endodontic emergencies31
irritation by bacterial toxins, can the pulp recover from Healing Attempts. Whether pulp inflammation can
this plight, or, in other words, is the pulpitis reversible? be reversed by treating the pulp, through the dentin,
with various medicaments also has long been in dispute. of the untreated coronal fracture results from infection
Langeland was quite pessimistic about these attempts.15 by oral bacteria gaining ready access to the pulp. It does
In a series of experiments testing the efficacy of peni- not matter how extensive the fracture is, only that the
cillin combined with camphorated monochlorophenol, pulp has been exposed to a mixed bacterial insult.
corticosteroids such as Mostellers solution or Ledermix Most coronal fractures involve the maxillary anteri-
(Lederle, Germany), silver nitrate, and microcrystalline or teeth, although posterior teeth are sometimes frac-
sulfathiazole, Langeland found them all ineffective tured in severe automobile accidents or sheared in half
antiphlogistics. It is true that these drugs initially in boxing accidents or fights. Classification of fractures
reduced pulpal pain, but in the long run, inflammation and their treatment and restoration are covered in
persisted or worsened. Pulps exposed to camphorated detail in chapter 15.
phenol, formocresol, formaldehyde, glutaraldehyde, and Incomplete Fracture. Incomplete fracture of the
procion dyes all suffered coagulation necrosis, which crown (infraction), often from unknown causes, fre-
was later followed by liquefaction necrosis and inflam- quently allows bacterial entrance into the pulp. Ritchey
mation in the adjacent pulp tissue.15 et al. reported 22 cases of toothache and pulp death
If the production of irritation dentin is any measure associated with incomplete fracture in molars.33 Pulp
of pulp health or recovery, researchers in Scotland infection and associated inflammation depend on the
reported significant development of tertiary (irritation) extent of fracture, that is, whether the fracture is com-
dentin following the application of various cavity lining plete, extending into the pulp chamber, or only
materials.32 Tertiary dentin formation was greatest through the enamel. In the former, pulpitis is certain to
beneath cavities lined with calcium hydroxide and least develop (Figure 4-12); in the latter, the pulp is merely
beneath cavities lined with materials (Ledermix), hypersensitive to cold and mastication.
[LederleGermany] containing corticosteroids.32 Nonfracture Trauma. Grossman reported pulp
This phenomenon proves once again the value of a canal infection from trauma without fracture of teeth.
mild irritant, such as calcium hydroxide, in stimulating After carefully swabbing Serratia marcescens into the
pulp recovery. On the other hand, severe irritants such gingival sulcus of incisors of dogs and monkeys,
as ZOE were not nearly as effective, and anti-inflam- Grossman dropped a weight onto individual teeth,
matory components such as corticosteroids actually which was heavy enough to traumatize but not to frac-
slowed repair to about one-third that achieved by calci- ture the tooth. About one-third of the time, S.
um hydroxide.32 marcescens could be recovered from the affected root
SUMMARY: One might summarize by repeating canals from 7 to 54 days later.34
that bacteria cause reparable as well as irreparable Anomalous Tract. Anomalous tooth development,
damage to the pulp. Taintor et al. best stated this par- of both the crown and the root, accounts for a substan-
ticular point while commenting on the pitfalls of tial number of pulp deaths, usually by bacterial inva-
assuming repair: sion. In each casedens invaginatus, dens evaginatus,
and/or radicular lingual groovesbacterial infection is
Using the crude parameters of pulpal diagnosis
the cause of pulp inflammation or tooth loss.
(that is, cold, warm, electric pulp test, percussion,
In the case of the internal (dens) anomalies, bacter-
palpation, and radiographic evidence), an initial
ial infection of the pulp through a development fault in
diagnosis must be made as to the status of the pulp.
the enamel cap or through caries in a deep pit is the
If it can be determined that the pulp is reversibly
route of invasion. In most of the external (develop-
inflamed[Ay, theres the rub] the course of treat-
mental groove) defects, the bacterial invasion is down
ment should be to remove the cause. The diagnosis
the defect in the root surface where the periodontal lig-
must be made on the basis of the above objective
ament cannot properly attach.
tests, the objective and subjective clinical signs and
Dens Invaginatus. Most dens invaginatus defects
symptoms, and confirmation of the carious extent of
are found in maxillary lateral incisors and range from a
the lesion by excavation (in one or more sittings). If
slight lingual pit in the cingulum area to a frank and
bacterial invasion of the pulp has occurred, the exca-
obvious anomalous tract apparent visually or radi-
vation will and should result in opening to the pulp
ographically (Figure 4-13).
and endodontic therapy should be performed.31
Oehlers classified these defects according to their
Fractured Crown. Complete Fracture. Accidental severity35 (Figure 4-14). Bhaskar described a coronal
coronal fracture into the pulp seldom devitalizes the and radicular dens.36 The coronal type may involve all
pulp at that instant. However, the inevitable pulp death of the layers of the enamel organ into the dental
B C
papilla. In these cases, the pulp may be exposed and type 3 defect, which opens through from the crown to
thus open to bacterial invasion, inflammation, and the apex (foramen caecum), ensuring bacterial inva-
necrosis. Periradicular lesions develop early. In the sion and infection (Figure 4-15).
radicular dens, there is a fold in Hertwigs epithelial Although most dens in dentes are unilateral, they
root sheath into the developing tooth, and enamel may be bilateral as well.3739 Although they are most
and dentin are produced there. This dens is Oehlers often found in the maxillary lateral incisors, where so
A D
many other anomalies develop, they may also be found Many dentists panic when faced with dens invagina-
in the maxillary central incisors, the mandibular inci- tus, particularly if a huge periradicular lesion or radic-
sors,37 and other teeth as well. Although not well docu- ular cyst is present. Extraction often follows panic.
mented, the clinical observation has been made of a Most of these cases can be treated endodontically,
higher than normal incidence of periradicular cysts including retrofillings.
associated with these cases.38,40 Dens Evaginatus. Dens evaginatus has a tract to
The prevalence of dens invaginatus may be higher the pulp at its point of attachment. It is a fairly com-
than generally credited. Frequencies as low as 0.25%41 mon occurrence in Asians.44,45 It is usually found on
but up to 6.9%42 have been cited. Japanese researchers mandibular premolars. Merrill also reported a high
surveyed the dental radiographs from 766 dental stu- incidence (4.5%) of this anomaly in Alaskan Eskimos,
dents and reported an incidence of 9.66% overall, with an observation serving to illustrate their ethnic ties to
46.8% of the affected teeth peg-shaped.43 Asian peoples.46,47
A B
A B C
Figure 4-17 A, Radicular lingual groove seen extending from the cingulum to the inflamed gingival margin. B, Periodontal probing reveals
the depth of pocket formation associated with the groove. C, Broad bone loss indicates chronic lesions. Narrow pockets, not easily discernible
by radiograph, are associated with acute lesions. Reproduced with permission from Robison SF and Cooley RL.60
A B
Figure 4-18 Radicular lingual groove extending to apex leading to irreversible pulpitis, palatal periodontal destruction, and
tooth loss. A, Depth and severity of groove. B, Hopeless outcome of combined endodontal-periodontal lesion. (Courtesy of
David S. August.)
Retrogenic Infection. Periodontal Pocket. The Although it has long been held that bacteria retro-
fact that the pulp does not frequently become infected genically infecting dental pulps must be blood- or
through the apical foramen or lateral accessory canals lymphborne and most likely arise from periodontal
associated with a chronic periodontal pocket attests to pockets, there has been no direct proof that this is so.
its inherent ability to survive. Seltzer et al. have shown Saglie and his associates at UCLA provided exquisite
increased atrophy and dystrophic calcifications in the proof that such a transport is possible, with the bacte-
pulps of periodontally involved teeth but not necessar- ria passing through the pocket lining to reach the
ily infection.63 Mazur and Massler, on the other hand, circulation.67 Their scanning electron microscopic
could not demonstrate these changes.64 studies of human periodontal pockets clearly showed
Periodontists often encounter periodontal pockets bacteria penetrating the ulcerated lining epithelium,
that extend to and surround the apex (Figure 4-20), as squirming through holes and tunnels left by leuko-
well as lateral accessory canals, or accessory canals in cytes migrating from the circulation and connective
the furca area of molars (Figure 4-21), which also tissue below, as well as from desquamated cells (Figure
extend into septic and infected pockets.65 In view of the 4-23). This bacterial movement toward the blood-
frequency of deep pocket occurrence, one is hard- stream could also explain the source of pulp infection
pressed to explain why retrogenic pulp infection is not when teeth are traumatized but not fractured.34
more common. Nonetheless, it does occur and, in com- Periodontal Abscess. Retrogenic pulp infection,
bination with the dystrophic changes observed,63 either accompanying or immediately following an
might well serve to explain why these pulps become acute periodontal abscess, is also an infrequent cause of
necrotic. Langeland and colleagues observed that otherwise unexplained pulp necrosis.
pathologic changes occurred in the pulp tissue when Hematogenic Infection. Bacteria gaining access
periodontal disease was present, but the pulp did not to the pulp through vascular channels is entirely with-
succumb as long as the main canalthe major pathway in reason. The anachoretic attraction of bacteria to a
of the circulationwas not involved.66 They found lesion readily applies to injured pulp tissue.68
that involved lateral canals or root caries damage the Anachoresis of bacteria from the vessels of the gingi-
pulp, but total disintegration apparently occurs only val sulcus, as explained above by Saglie et al.,67 or
when all main apical foramina are involved in the bac- from a systemic transient bacteremia also serves to
terial plaque (Figure 4-22). One should also be aware explain the unusual number of infected pulp canals,
that accessory or lateral canals may not be truly func- following impact injury without fracture, to 46 intact
tional, having been blocked internally by sclerosis or teeth, observed by MacDonald et al.69 and experimen-
advancing irritation dentin. tally by Grossman.34 The so-called stressed pulp
A B
C
Figure 4-20 Differential diagnosis of retrogenic pulp infection from periodontal pocket. A, The pulp of the lateral incisor is infected and
necrotic and apparently related to the distolingual pocket that extends to the apex. Occlusal traumatism may be a factor, although there was
no history of impact trauma. B, Radiographic appearance mistakenly diagnosed as chronic apical periodontitis. Notice extreme incisal wear.
Pulp is vital in the involved central incisor. C, Same case as B. The orifice to the labial periodontal lesion is apparent, as well as the traumatic
relationship between the maxillary and mandibular incisors. The pulp is not involved in spite of the extensive pocket.
could well be a haven for blood- or lymphborne bac- teeth with Dycal (L.D. Caulk, Milford, Dela.), calcium
teria. Injured or scarred tissues appear to have an hydroxide, or Teflon. Bacteria were not observed in
affinity for attracting bacteria, as shown by the bacte- the control teeth or in three of four of the Teflon cap-
rial plaques that form on heart valves scarred by rheu- pings. But in all of the mildly inflamed calcium
matic fever. In Greece, Tziafas produced a streptococ- hydroxide cappings, however, colonies of gram-posi-
cal bacteremia in dogs after having pulp-capped 36 tive cocci were found.70
TRAUMATIC CAUSES
Acute Trauma
Coronal Fracture. Most pulp death following coro-
nal fractures is incidental to the bacterial invasion that
follows the accident. There is no question, however, that
severe impact injury to the coronal pulp initiates an
inflammatory attempt toward repair. Untreated bacter-
ial invasion negates any possibility of sustained vitality.
Radicular Fracture. Accidental fracture of the root
disrupts the pulp vascular supply; thus the injured
coronal pulp can lose its vitality. The apical radicular
pulp tissue, however, usually remains vital.
A One should not assume pulp death too soon after an
accident. Complete repair of the fracture by callus for-
mation of cementum has been known to occur (see
chapter 15). Moreover, the blood supply may remain
viable, either through the apical vessels or through the
ingrowth of new vessels through the fracture site.
As with any other condition affecting the pulp, the
younger the patient, the better the prognosis for pulp
vitality. The extensive vascular supply through the
incompletely formed root end provides a much greater
opportunity for repair than the fractured root and dis-
rupted blood supply of a fully formed tooth.
Vascular Stasis. The tooth that receives a severe
B impact injury, yet is not dislocated or fractured, is more
apt to lose pulp vitality immediately than the tooth that
fractures. Evidently, the pulp vessels are either severed
or smashed at the apical foramen, resulting in ischemic
infarction.
Pulp canal calcification by irritation dentin is anoth-
er pulp response to trauma. Thus the pulp may either
die from trauma or furiously eliminate itself by irrita-
tion dentin formation. Conversely, impact trauma may
lead to internal resorption in which the pulp attacks
the dentin rather than builds it. For a more complete
discussion of pulp necrosis subsequent to pulp canal
obliteration owing to trauma, see chapter 15.
Again, after trauma, the possibility exists for pulp
C repair and revascularization depending on the age of
the patient. The developing tooth with an open flaring
Figure 4-21 A, Bony lesion in furcation draining through buccal apex is quite apt to remain vital or regain vitality. In the
gingival sulcus. The molar pulp is necrotic. B, Obturation reveals older patient, the prognosis for repair is limited.
the lateral accessory canal. C, Three-year recall radiograph. Total
Luxation. Extrusive and lateral luxation and intru-
healing is apparent. No surgery was used. (Courtesy of Dr. Rafael
Miana, Madrid, Spain.) sion nearly always result in pulp death. Pulpal recovery
is possible in young, immature teeth with wide, open
apexes, however.
Avulsion. It goes without saying that pulp necrosis
is the obvious consequence of total avulsion of a tooth.
In spite of pulp death, however, the tooth should still be
replanted (see chapter 15).
A B
Figure 4-22 A, Accessory canal (arrow) from vital pulp into the inflamed tissue of molar bifurcation. B, Inflammation in the accessory canal
with only slight inflammation in the canal pulp. Epithelial rests (arrows) are present in both bifurcation and pulp canal. Reproduced with
permission from Rubach WC, Mitchell DF. J Periodontol 1965;36:34.
A B
C D
Figure 4-24 Osteoporosis and pulp death of mandibular incisors in a 14-year-old girl who compulsively ground her teeth in protrusive excur-
sion. A, Position assumed during bruxism. B, Extensive wear of mandibular incisors caused by compulsive grinding. C, Pulps of three incisors
have been devitalized by the force of traumatic habit. Acute abscess has separated central incisors. D, One year following root canal therapy,
some repair has occurred; however, persistent habit prevents complete healing. Reproduced with permission from Natkin E and Ingle JI.72
A B
Figure 4-27 Toothbrush abrasion into the pulp cavity. A, The pulp canal is evident on the first premolar. A hard-bristle brush was used
since childhood. Reproduced with permission from Gillette WB, Van House RL. JADA 1980;101:476. B, Attrition from dentifrice abrasion
extends almost completely through the incisors. Reproduced with permission from Meister F, Braun RJ, Gerstein H. JADA 1981;101:651.
Figure 4-28 Iatral pulp death frequently occurs when teeth must
be reduced to this extent. It is imperative that copious water coolant
be used to protect pulp from heat damage and desiccation during
preparation.
Swerdlow and Stanley pointed out the basic factors the edema, hyperemia, and exudation occurring in
in rotary instrumentation that cause temperature rise proximity to the pulp wall literally forced the odonto-
in the pulp. In order of their importance, they are as blast nuclei and blood cells into the dentinal tubules.
follows: Confirming this thesis and using cellular displace-
ment into the tubules as a criterion for pulp inflamma-
1. Force applied by the operator
tion, Ostrom, in an ingenious experiment, was able to
2. Size, shape, and condition of cutting tool
show that the heat of preparation causes pulp inflam-
3. Revolutions per minute
mation during preparation and that the cellular dis-
4. Duration of actual cutting time83
placement into the tubules is the result of the pressure
One would surmise that the ultraspeed (300,000 generated from intrapulpal inflammation following the
rpm) instruments of today are more traumatic to the temperature rise.90
pulp than the low-speed (6,000 rpm) instruments of the After reviewing the research in this area, Goodacre
past. Such is not the case if adequate air-water coolant is concluded that low speed produces less thermal eleva-
used. Stanley and Swerdlow concluded that speeds of tion than high speed which produces less elevation
50,000 rpm and over were found to be less traumatic to than ultrahigh speed.91 He also quoted Ottl and Lauer,
the human pulp than techniques using 6,000 and 20,000 who noted that carbide burs generate less thermal
rpm.80 They pointed out, however, that the value of change than diamond instruments and that coarse
coolants becomes more significant at higher speeds. It is diamonds produce a more pronounced temperature
possible to burn the pulp in 11 seconds of preparation increase than fine diamonds.92
time if air alone is used as a coolant at 200,000 rpm. Depth of Preparation. It can be stated categorical-
This concurs with the findings of Vaughn and Peyton, ly that the deeper the preparation, the more extensive
who showed that the highest intrapulpal temperatures the pulp inflammation. This has been shown by Seelig
were reached within the first 10 seconds of grinding.84 and Lefkowitz, who observed the degree of pulp
Peyton and Henry also demonstrated that the tempera- response as inversely proportional to the remaining
ture rose up to 110F at 15,000 rpm if no coolant was thickness of dentin.93
used while cutting with a No. 37 inverted cone diamond The effect on the pulp of merely cutting on the
point at a 0.5 pound load.85 dentin was well demonstrated by Searls.94 Carefully
Stanley emphasized the destructive intervention of preparing cavities with a 3312 bur on rat incisors at
cavity preparation. In his experience, he found that a 150,000 rpm under a jet stream of water, Searls noted
pure acute inflammatory lesion seldom exists except that the uptake of labeled proline was substantially
following severe traumatic episodes or cutting a cavity reduced in those odontoblasts the processes of which
preparation [emphasis added] in an intact tooth. It is had been cut. A surprising finding was the reduced pro-
his contention that the demise of the pulp begins with tein synthesis in the pulp adjacent to the cut tubules as
a chronic lesion turned acute by the insult of cavity well, as revealed by the tritiated proline.94
preparation (stressed pulp), so to speak. At that time, Pulp Horn Extensions. The close proximity of the
leukocytes are found in the pulp lesion.86 pulp to the external surface of the tooth, particularly at
As Zach noted, There is good histologic validation the furcal plane area, where tooth preparation for full
that an increase in intrapulpal temperature of 20F may coverage of periodontally involved teeth is so critical,
result in irreversible damage to a substantial number of has been emphasized by Sproles95 and by Stambaugh
pulps so assaulted.87 Using four different techniques and Wittrock.96 At some points, the pulp is only 1.5 to
to prepare cavities, Zach found low-speed drilling with 2.0 mm away before preparation is even begun. Stanley
no coolant to be the least acceptable method, followed and Swerdlow pointed out the increased importance of
by ultraspeed with no coolant. He also found desicca- air-water coolant as the dentin is thinned and the pulp
tion from air cooling quite damaging. Langeland and approached.89
Langeland also noted that desiccation may accentuate In a remarkable investigation of the coronal pulp
the effects of cavity preparation in the pulp.88 chambers of maxillary and mandibular molar teeth,
Stanley and Swerdlow stated that the degree of cellu- Sproles discovered never-before-reported cervical pulp
lar displacement of odontoblastic nuclei into the cut horns (Figure 4-30). Found 66.8 to 96.3% of the time in
dentinal tubules is the best indication of the severity of the first and second molar teeth (Table 4-1), this extra
pulp inflammation initially.89 They felt that this dis- pulp horn presents a real danger in cavity preparation.95
placement of the cells was caused by a buildup of intra- Sproles pointed out that the exact location of this
pulpal pressure by an inflammatory response and that pulp extension is most frequently found at the
Maxilla
1st molar 96.3 70.3 22.2 53.7 11.1
2nd molar 73.6 59.5 8.0 20.2 8.7
Mean 84.9 65.1 15.1 36.9 9.9
Mandible
1st molar 71.8 61.5 24.4 14.1 19.3
2nd molar 66.8 61.1 31.6 12.2 8.1
Mean 69.3 61.3 28.0 13.1 13.7
*Occurrence of extra cervical pulp horns as first described by Sproles. Percentages do not add to 100 because multiple horns may appear
on any single tooth. Moreover, the midbuccal or midlingual locations are not reported above.97
although the blushing has been seen to disappear in revealed in 1989 that half of Americas dentists used
time. At a later time, most pulps that appear to have retentive pins in restoring compromised teeth. In 1988,
clinically recovered have actually succumbed to the they placed 11 million pins.101 Research from North
violence of their initial response. Carolina suggested that those 11 million pins may have
Microhemorrhages are probably a common occur- caused somewhere between 4.4 million and 8.5 million
rence during cavity reparation, a finding demonstrated pulp exposures. Chapel Hill researchers placed a range
by Orban as early as 1940.100 Fortunately, recovery of pin sizes properly positioned in 60 extracted molar
from these minor hemorrhages is the rule rather than teeth. When only one regular pin was placed, they were
the exception. appalled to find that cracks extended into the pulp 73%
Pulp Exposure. The increased incidence of pulp of the time. Even the smallest pins caused pulp expo-
death following pulp exposure has been experienced by sures 40% of the time.102 If one extrapolates this 73%
all dentists. If at all possible, a layer of solid (not leath- finding by using chance analysis, two pins would cause
ery) dentin should be allowed to remain as pulp pulp exposures 93% of the time and three pins 98% of
cover.25,31 The numerous methods devised and drugs the time.
used to cap pulp exposures, and the discouraging Suzuki and colleagues found pulp necrosis in their
results reported for pulp capping, verify the impor- experimental specimens in which pulp exposure had
tance of maintaining pulp integrity. occurred and in which the pins had been placed with-
Occasionally, a pulp exposure is made unknown to out the presence of calcium hydroxide103 (Figure 4-32,
the dentist because there is no bleeding. The first indi- A). In some cases, in which preparation and placement
cation of a problem is the patients complaint of pul- were too close to the pulp, dentinal fractures occurred
palgia when the anesthesia wears off. A radiograph with resultant pulp inflammation just beneath (Figure
reveals the exposure and cement forced into the pulp 4-32, B). When preparation and placement were near
(Figure 4-31). the pulp, and in the presence of calcium hydroxide,
Pin Insertion. Since the advent of pin placement however, irritation dentin formed to protect the under-
into the dentin to support amalgam restorations, or as lying pulp, which remained normal103 (Figure 4-32, C).
a framework for building up badly broken down teeth Pulp damage from pins may become a moot point.
for full-crown construction, an increase in pulp Pins are gradually being replaced by dentin adhesives
inflammation and death has been noted. Undoubtedly, that bond buildup materials to tooth structure.
in some cases, the trauma of preparing and inserting Impression Taking. Seltzer et al. showed that dam-
the pins is insult enough to finish off an already aging pulp changes may develop when impressions are
stressed pulp. In other cases, however, the pins may taken under pressure.5 In one instance, bacteria placed
have been inadvertently inserted directly into the pulp into a freshly prepared cavity were forced into the pulp.
or so close to it that they acted as a severe irritant. It was One might well extrapolate these experimental findings
to apply them to impressions taken with force, in deep
cavities or full-crown preparations. Moreover, the neg-
ative pressure created in removing an impression may
also cause odontoblastic aspiration.
Restoration
Insertion. Severe hypersensitivity and pulpalgia,
symptomatic of underlying pulp inflammation and
subsequent necrosis, have been noted following the
insertion of gold foil and silver amalgam restorations.
Foil insertion is evidently far more traumatic to the
pulp than amalgam insertion using foil over amalgam
in a ratio of 9 to 1 (University of Washington, unpub-
lished data, 1964). James and Schour found gold foil to
be the most irritating of eight filling materials.104
Patients sometimes report protracted pulpalgia or
hypersensitivity following the insertion of silver amal-
Figure 4-31 Cement forced into pulp during cementation. gam restorations. Again, this could be related to the
Pulpitis and severe pulpalgia resulted. force of insertion or possibly to the expansion of the
C D
Figure 4-32 A, Pin placement directly into coronal pulp with subsequent pulpalgia, necrosis, and periradicular lesion. Reproduced with
permission from Cooley RL, Lubow RM, Wayman BE. Gen Dent 1982;30:148. B, Pin placement with calcium hydroxide. Note dentinal cracks
from the force of insertion (arrow). Cracks filled with calcium hydroxide. Moderate pulp inflammation under affected tubules. C, Pin place-
ment with calcium hydroxide and no dentinal fracture. Irritation dentin response is apparent at 28 days. The remaining dentin thickness is
0.5 mm. D, Pin placement into pulp. Note the fractured roof of the pulp chamber, severe inflammation, and necrosis. Arrows indicate grooves
cut in the dentin by a screw-type pin. B, C, and D reproduced with permission from Suzuki M, Goto G, Jordan RE. J Am Dent Assoc
1973;87:636.
amalgam after insertion. In any case, it seems reason- times complain of hypersensitivity or pulpalgia for
able to assume that pulp pain is an outgrowth of pulp months following the placement of a foil, inlay, or
inflammation. Swerdlow and Stanley reported pulp amalgam only to gain relief when a cusp finally frac-
changes when amalgam was condensed into fresh cavi- tures away or the crown fractures horizontally. Ritchey
ties prepared with high-speed equipment.105 No signif- et al. listed 22 cases of pulpalgia related to incomplete
icant differences in pulp response were noted, however, fracture of posterior teeth restored with soft gold
between hand and mechanical condensation. inlays.33 Incomplete fracture is further complicated by
Pain following the insertion of glass ionomer bacterial invasion through the microscopic fracture
cements and/or composite resins has also been report- line (see Figure 4-12, C).
ed. This phenomenon is dealt with in some depth later There is no question about pulp insult when a com-
in the chapter. plete fracture into the pulp develops as a result of inlay
Fracture. Incomplete fracture may be a sequela to or three-quarter crown placement or removal. In addi-
restoration with either gold or silver. Patients some- tion to the typical vertical fracture, a number of hori-
zontal fractures have also been seen, developing at the ment of fixed partial abutments that range from 3%
gingival and following a cleavage line that was set up after 5 to 10 years, up to 21% after 6 years, to as high as
during the placing of a Class V foil. 23% after only 2 years.91 He further noted that the
Force of Cementing. Unanesthetized patients spanthe length of the prosthesisalso affected the
often complain of pulp pain when an inlay or crown is need for endodontic treatment; again, needs ranged
finally cemented. Occasionally, the pain does not wear from 7% following a 7-unit prosthesis to a 38%
off, and the dentist realizes that the final cementation endodontic need in a 12-unit fixed bridge.91 Also, fol-
was the coup de grce to a sick pulp. Undoubtedly, the lowing the concept of the stressed pulp, he pointed out
chemical irritation of the cement liquid is a factor, but, that 3% of the teeth with little or no caries required no
on the other hand, the tremendous hydraulic force endodontic treatment after 5 years, whereas 10% of the
exerted during cementation could not help but drive teeth with deep carious lesions required treatment.91
the liquid toward the pulp. The pressure exerted would The number of pulps surviving the rigors of restora-
be similar to the force exerted in taking a full-crown tion is surprising when one considers the trauma to the
impression. pulp from cavity preparation, the desiccating effect of
The saving grace in most cases is the protection pro- chip blowing, the chemical irritation of a cement base
vided to the pulp by the smear layer produced during or luting cement, the trauma and prolonged operating
cavity preparation. Microcrystalline obstruction of the time of insertion, and the heat generated in finishing.
tubuli orifices can be negated, however, by scrubbing Those pulps that do not survive might well have been
the dentin cavity surface or applying acid or ethylene- stressed to their limit by previous carious, traumatic,
diaminetetraacetic acid (EDTA) cavity cleansers. and treatment insult. The new round of therapy could
Cavity liners, dentin bonding agents, or thin cement be the proverbial straw that broke the camels back.
bases have much to recommend their use.
Heat of Polishing. Finally, but by no means last in Intentional Extirpation and Root Canal Filling
order of iatral importance, the pulp damage caused by A number of situations arise in restorative dentistry,
polishing restorations must be considered. This dam- particularly periodontal prosthesis, for which inten-
age may be compounded by polishing with dry pow- tional extirpation of the pulp is indicated. Total root
ders while the tooth is anesthetized. The subsequent amputation or hemisection of periodontally involved
temperature increase gives rise to the same pulp dam- roots also requires intentional extirpation of the
age previously discussed under cavity preparation. remaining pulps. A number of situations have been
Interproximal finishing of gold foils, silicates, or com- documented by Bohannan and Abrams,108 who listed
posites with 18-inch finishing strips without a constant the following indications for intentional extirpation:
air coolant must be condemned as well. reorientation of the occlusal plane of tipped, drifted, or
Summary. Having said all of this, there is little elongated teeth; (see Figure 4-28); reduction of the
wonder that Felton and his colleagues at North crown-root ratio in the face of advanced loss of bony
Carolina found such a high incidence of pulpal mor- support; and the establishment of parallelism of clini-
bidity and necrosis under restorations. They compared cal crowns when a fixed prosthesis is being used. Add to
1084 teeth restored with onlays, crowns, or bridges in these indications the necessity to use the root canal for
service for 3-30 years with a similar number of unre- dowel retention of a crown, plus intentional extirpa-
stored control teeth. Statistical analysis (p < .01) tion of the pulp of a tooth, badly drifted to the labial,
revealed a higher incidence of pulpal necrosis associ- that is now being restored with a jacket crown to a
ated with full coverage restorations (13.3%) compared more esthetic relationship. The pulp must be entered to
to partial veneer restorations (5.1%).106 If an amalgam cut the preparation far enough back into the arch.
or composite buildup was placed, the incidence of Abou-Raas also recommended intentional extirpa-
necrosis rose to 17.7 and 8.1%. They also found a pos- tion and root canal filling as a prelude to internal
itive relationship between the length of time the tooth bleaching of teeth badly stained from prolonged tetra-
was temporized and the number of pulps that became cycline ingestion.109
necrotic.106 This latter finding could well be owing to
bacterial microleakage and/or damage from the heat Orthodontic Movement
generated when plastic, temporary crowns are fabricat- Although orthodontists may deny the possibility, den-
ed directly on the freshly cut preparation.107 tal pulps can be devitalized during orthodontic move-
Goodacre noted that several studies have pointed to ment. Not only devitalization but also hemorrhage can
the need for endodontic treatment following the place- occur, for when the patient presents for endodontic
therapy, the tooth may be discolored. Paradoxically, the and focal necrosis of the odontoblasts when monkey
maxillary canine, which is seldom devitalized by other teeth were subjected to 2,370 joules/cm. At 2,800
trauma, appears to be the tooth most susceptible to joules/cm, coagulation necrosis of the pulp occurred.
pulp hemorrhage and necrosis under the forces of More recently, however, the neodymium laser has
orthodontic movement; ischemic infarction is proba- been considered a more effective welding agent than
bly the best explanation. the ruby laser. Adrian again tested the effects on the
As proof that orthodontic tooth movement does pulp of the neodymium laser and found that although
affect pulp viability, Hamersky and colleagues found a the damage was considerably less than that caused by
27% depression in pulp tissue respiration as a result of the ruby laser, it was still enough for concern.117 Even
orthodontic force application.110 at two to three times the intensity of the ruby laser
Studies of the effects on the pulp from intrusive (6,772 joules/cm), in no case did coagulation necrosis
forces have also demonstrated compromised blood of the pulpal contents occur with the Nd (neodymium)
flow to the pulp in rats111 and marked changes in the laser although Grade 2 pulp inflammation did develop
dentin and pulps in the teeth of 60 children undergo- below enamel-dentin burns.117
ing intrusive forces.112 In Paris, Melcer et al. tested the carbonic gas laser
that emits energy densities between 10 and 25
Periodontal Curettage joules/cm2.118 In the United States, Powell et al. con-
Although root planing and root curettage have been ducted CO2 laser tests on the enamel of dogs teeth but
shown to stimulate the deposition of irritation used laser power densities as high as 102 joules per
dentin,113 extended curettage can result in pulp devi- cm2.119 Miserendino et al. tested a CO2 laser with 30 to
talization. During curettage of a periodontal lesion that 250 joules. They observed intrapulpal temperature
extends entirely around the apex of a root, the pulp ves- increases ranging from 5.5 to 32C. Laser exposures
sels may be severed and the pulp devitalized. Pulp vital- below 10 joules, however, produced rises below 5.5C,
ity is a small price to pay if the tooth can be retained by an acceptable level.120
periodontal curettage followed by root canal therapy. Low-density laser has been suggested for caries
removal. In Class V cavities, French researchers subject-
Electrosurgery ed the pulpal floor to eight impacts of short duration,
The possible damaging effects of electrosurgery on the 0.2 second up to 2.0 seconds: With an energy of 15
pulp were explored by Robertson and his associates.114 joules emitted in eight pulses of 3W, 0.6s, a new miner-
In their experiment with monkeys with and without alized dentin formation was observed. In the pulp tis-
Class V amalgam fillings, electrosurgical current was sue, consisting of 70 percent to 80 percent water, the
delivered for one second with a fully rectified unit at an CO2 laser beam was almost completely absorbed.118
output intensity consistent with normal clinical usage. Powell et al. irradiated the enamel of dogs teeth with up
Electrosurgery, involving cervical restorations, consis- to 10 times the power used in dentin and reported no
tently resulted in coagulation necrosis of the pulp and damage.119 This was confirmed by another group of
extensive resorption of cementum, dentin and inter- French researchers, who irradiated dogs teeth at two
radicular bone in the furcation area of multirooted levels: 285 joules per cm2 and 570 joules per cm2. In
teeth.114 Krejci and his associates produced similar Class V cavities, they obtained dentinal sealing without
results in beagles. No damage occurred at 0.4 seconds, affecting the underlying pulp.121
but at 0.8 to 1.1 seconds, hemorrhagic necrosis of the It appears, therefore, that the emission of the CO2
pulp was found when Class V amalgams were contact- laser beam, characterized by a low power and short
ed with the electrode.115 These results certainly suggest periods of emissionproduces a fast and constant reac-
that inadvertent contact with metallic restorations dur- tional dentinogenesis without necrotic alteration118
ing electrosurgery may severely endanger the pulp and
periodontal structures alike. Periradicular Curettage
A not infrequent result of periradicular surgery is the
Laser Burn devitalization of the pulps of adjacent vital teeth dur-
Laser beams are sometimes used to weld dental materi- ing curettage of an extensive bony lesion (Figure 4-33).
als intraorally, particularly gold and nickel-chromium This iatral devitalization of normally vital pulps most
alloys. Ruby laser radiation has been shown by Adrian frequently occurs in the mandibular incisor region.
and his colleagues to be most damaging to the pulp.116 Two cases reporting the surgical removal of cemen-
They found severe hemorrhage in the pulp chamber tomas in the mental region are of note.122,123 Keyes and
Figure 4-33 Pulp death caused by periradicular curettage during cyst enucleation. The huge apical cyst seen initially (left) is related to only
one pulpless tooth that has been treated (center) and the cyst thoroughly enucleated. Examination of a 1-year postoperative radiograph
(right) reveals radiolucency (arrow) apical to the lateral incisor devitalized during curettage.
Hildebrand reported a case of a 12-year-old girl with a tion.126,127 On the other hand, human studies by Bell
huge third-stage cementoma associated with a nonvital and his surgical group in Dallas were most encourag-
mandibular central incisor. Root canal therapy failed to ing. After following 10 patients who had had Le Fort I
relieve the painful symptoms, so the cementoma was osteotomies, as well as other maxillofacial surgery, Di et
removed.122 In the second case, reported from al. reported intact pulp circulation in teeth within the
Jerusalem, all of the lower incisors involved in a rela- surgical sites and no significant differences in tooth
tively asymptomatic, second-stage, benign cementoma development between the surgical and control
were vital. Following surgery, however, both lateral groups.128 Surgery done with great care and precision
incisors were devitalized and required endodontic appears to spell the difference.
treatment.123
The possibility of this accident is good cause for the Intubation for General Anesthesia
limitation of promiscuous periradicular surgery in this A relatively common operating room accident, the lux-
region. If endodontic surgery is absolutely indicated, ation of the mandibular incisors, may be caused by the
accidental devitalization is less likely to occur if great heavy retraction against these teeth with an inflexible
care is exercised to avoid the tissue around adjacent endotracheal tube. Cases have been seen following ton-
teeth. A marsupial surgical technique has also been used. sillectomy with all four mandibular incisors luxated. A
survey of 133 anesthesiology training programs
Rhinoplasty revealed that the average incidence of dental injuries in
Nasal plastic surgery may be the cause of pulp death. Glick 1,135,212 tracheal intubations was 1 in 1,000. Broken
reported three cases of pulp death in maxillary anterior teeth accounted for the same number of complications
teeth following plastic reconstruction of the nose (person- as did cardiac arrest, 37.5%. As a matter of fact, dam-
al communication, 1978). Root tips of maxillary central aged teeth was the most frequent anesthesia-related
incisors have been fractured during this operation. insurance claim from 1976 to 1983.129
injury is of prime concern. This statement by Dubner the ZOE cements in their study150 (Figure 4-37). Valcke
and Stanley is echoed by virtually all of the early inves- and his South African associates were also surprised to
tigators in the field.141 James and Schour suggested that find ZOE cement to be more toxic than silicate.131
ZOE may even have exerted a palliative effect on the Cox and Bergenholtz had the same experience as
pulp.132 Quite possibly, this so-called palliative effect Valcke using ZOE as a control against silicate, zinc
is related to the obtundent effect eugenol exerts on sen- phosphate, calcium hydroxide, amalgam, and two com-
sory nerves, rendering them less capable of carrying the posites, all inserted into the pulp. However, ZOE came
pain message to the brain. off the worst, with mononuclear cell infiltrates and no
In view of the strong lobby for ZOEs supposedly hard tissue repair at 21 days.138
bland effect on the pulp, it is surprising to learn that In view of the more recent evidence that ZOE
Brnnstrm and Nyborg believe ZOE to be more nox- cement is not as soothing as long thought (periodon-
ious than either zinc phosphate or polycarboxylate tists gave up ZOE perio-pack years ago, and pedodon-
cements.143 Mjr pointed out that ZOE cement tists and endodontists are fully aware of the damaging
appears to have marked bacteriostatic and bacterioci- effects of ZOE cement against a pulp exposure), one
dal effects but cannot be counted on to sterilize infect- must carefully consider the advice to use calcium
ed carious dentin.144 Das found ZOE cement toxic to hydroxide cavity liner when ZOE is used as a cement
human dental pulp cells in tissue culture. Moreover, he base or as a luting medium. Remember, in the same
found that zinc oxide powder alone was toxic, as were study showing ZOE cement and zinc oxide powder to
gutta-percha points, which are heavily filled with zinc be toxic, Das found calcium hydroxide nontoxic to
oxide.145 This is not surprising in view of the findings human pulp tissue cells.145
of Meryon and Jakeman that the zinc released at 14 Cavit (Premier Dental; Norristown, Pa.), the
days from ZOE was a strong toxin in vitro against resin-reinforced, ZOE temporary cement used exten-
human fibroblasts. Absorption of the released zinc by sively in pulpless teeth, enjoys less favor in temporizing
the remaining dentin on the cavity floor is the pulps vital teeth because of the pulpal discomfort that
saving grace.146 ensues. When Cavit is placed against dentin covering a
Meryon further tested ZOE to determine the toxic vital pulp, it causes desiccation. Although Cavit, like
effect of eugenol. She found that eugenol could pass the ZOE, is hydroscopic, it has a sixfold greater water
dentin barrier. The thicker the remaining dentin thick- absorption value than ZOE. The pain on insertion
ness, however, the less toxic the effect of eugenol. undoubtedly arises from fluid displacement in the
Meryon stated that eugenol release occurs as a result of dentin tubuli. Therefore, Cavit should always be placed
hydrolysis of zinc eugenolate. Removal of the smear in a moist cavity. Provant and Adrian found no statisti-
layer increased the passage of eugenol to the pulp.147 cal difference between Cavit and ZOE as far as pulp
Brnnstrm and Nyborg believe that ZOE also exerts reaction was concerned.151
a dehydrating effect. That effect, plus 5 seconds of air- Red and black copper cements have been found to
drying the experimental cavities, could have caused the be quite irritating to the pulp and have practically
damage from desiccation apparent in their slides. In any passed from use.
event, they recommended that a calcium hydroxide Polycarboxylate cements, a mixture of resin and
liner be placed before ZOE cement is used as a base.148 zinc phosphate cements, have been heavily advertised
In another study, Brnnstrm and his associates as adhesives. Evidently, they do adhere to enamel and
found that IRM cement (Caulk-deTrey, USA and also initially adhere to dentin, although this latter bond
Switzerland) (ZOE strengthened with polymethyl- is soon broken. Langeland and colleagues tested two
methacrylate) produced slight to moderate pulp polycarboxylates against pulp reaction in monkey
inflammation if the dentin thickness was less than teeth,152 as did Lervik142 and Brnnstrm and
0.5 mm. Again they recommended calcium hydroxide Nyborg.148 All reported favorably on the carboxylates.
as a cavity liner.149 The results indicate that polycarboxylate cements
In a fastidious study reported by Cook and Taylor, a per se are relatively inert. If used as a base or cavity
number of ZOE cements were tested for toxicity.150 liner, care should be taken to secure full coverage of all
Injected in their unset state into the belly walls of rats, exposed dentin to prevent reactions from microleakage
the reaction areas were then examined histologically at reaching the dentin.
2, 16, and 30 days. After reviewing the numerous favor- Plastics. The commonly used plastic filling mate-
able reports on ZOE, Cook and Taylor seemed some- rials are amalgam (which is not usually thought of as a
what surprised to find the degree of toxicity caused by plastic, although it is so physically if not chemically),
Sybraloy 30 3 4 7 6 13
Disperalloy 12 5 1 14 0 7
Indiloy 13 3 3 10 0 10
Royal Dental Alloy (control) 5 5 2 11 2 10
*Pulp reaction to various amalgams at 1 week and at 2 to 3 months observation period. Note that half of the reactions were unacceptable
in teeth tested with Sybraloy, a 30% copper content alloy. Disperaloy (12% copper) and Indiloy (13% copper) fared as well as the con-
ventional alloy, Royal Dental (5% copper).
Contains 5% indium.
as temporary crowns accounts, in part, for the great ing. However, they knew, collectively, that the chemi-
number of latent pulp deaths under extensive restora- cals caused pulp inflammation. Pulp protection was
tive cases. One must also consider the damaging effect therefore recommended.
of the heat generated as the plastic material self-cures In early in vitro testing of the composites, Dickey
on the freshly cut preparation. Tjan and colleagues at and colleagues found Adaptic as toxic as silicate.172 It
Loma Linda University found as much as a 19C tem- has since been removed from the market. Langeland
perature rise under some directly placed provisional also found no significant difference in pulp irritation
crowns. They also found that the temperature increase between the silicates, cold-cure plastics, and composite
could be significantly reduced if silicone putty impres- resin materials.173 Langeland et al. added, however, that
sions were used as a matrix.107 A 5.5C rise in temper- used with an adequate protective base, these materials
ature has been shown to be damaging to the pulp.82 are biologically acceptable, and because of their good
To prove the point that there is a difference between physical properties, superior to other anterior
in vitro and in vivo research results, a group in London tooth-filling material.174 Quite possibly, Langelands
tested two different methacrylate temporary crown adequate protective base was in reality serving as a
materials on monkeys.166 At 4 weeks, they found nor- dentin sealant preventing microleakage and subse-
mal pulp tissue under both acrylics as well as a small quent pulp inflammation.174
quantity of reparative dentin. The crowns, however, In spite of the laudatory reports regarding the phys-
were well sealed against microleakage. ical and esthetic properties of the composites, prob-
As far back as 1959, Zander voiced the fact that it lems have developed around the alleged irritation from
was bacteria from microleakage that was the culprit their chemical constituents and attempts to improve
causing pulp reactions, not the acrylics per se.167,168 their adhesive qualities. Stanley and his associates
Microleakage can best be controlled by marginal fit. noted that, early on, investigators thought methacrylic
Because temporary crowns are just thattemporary acid was the primary pulp irritant.175 Therefore, efforts
not enough attention is paid to this important feature. were made to remove it from the newer composite for-
The UCLA materials laboratory tested the marginal accu- mulations and to establish a neutral pH as well. It was
racy of nine popular brands of temporary restorative shown, however, that removing methacrylic acid and
materials. They found SNAP (Parkell Co., USA) to give adjusting the pH in composite liquid provided no
the best fit and Neopar (Kerr Co., USA) to be the worst. improvement in pulp reaction. Stanley further stated
The other seven materials were scattered between.169 that the composite manufacturers, apparently con-
Composite Resins. In their in vitro study, cerned with the toxicity of their products, have divert-
Spangberg and colleagues determined that Although ed their research efforts to improving color stability
when freshly prepared the composite materials cause and physical properties or developing a better cavity
less cell damage than the silicates or cold-curing plas- liner or dentin bonding agent. He is adamant (as are
tics, the composites resemble the silicates in that they most of the manufacturers) that any composite filling
give off irritant components over a longer time than should be preceded by a protective base or, better yet,
the cold-curing plastics.170 The composites contain one of the new nontoxic cavity liners or bonding
acrylic monomers in their catalyst system, and it can be agents.176 Stanley later noted that only when the
assumed that the monomer would cause damage, as in recently developed dual-cure resin cements are not
the case of the cold-curing resins. adequately cured with visible light do significant pulpal
In addition to their principal and diluent monomers, lesions appear.176
composite resins contain other organic chemicals such In the previously quoted research effort, Cox and
as silane coupling agents, polymerization inhibitors, ini- Bergenholtz placed composite resins directly into pulp
tiator-activator components (benzoyl peroxide), and exposures in deep cavities prepared in monkey teeth.138
ultraviolet stabilizers. Various inorganic fillers (glass Under resin-capped exposures, sealed against
beads and fibers, quartz, silicon dioxide, etc) are also microleakage by ZOE overfillings, they found normal
added to modify the physical characteristics. pulp tissue architecture against the composite interface,
To determine their individual effect on the pulp, in all four teeth, at 21 days. Hard tissue repair was also
Stanley et al. separately tested each of the eight cate- present in the ZOE-sealed restorations (Figure 4-39,
gories of chemical compounds that collectively form A). All of the composite-capped (unsealed) exposures
contemporary composite restorations.171 They were that exhibited microleakage showed some degree of
surprised to find at 21 days that none of the individual stained bacteria as well as pulp tissue breakdown,
components could be considered significantly irritat- severe inflammation, and necrosis (Figure 4-39, B).138
A B
Figure 4-39 Prevention of microleakage prevents pulp irritation. A, Composite resin-capped pulp after 21 days sealed from oral bacteria
by zinc oxideeugenol overfilling. Note odontoblasts and new hard tissue adjacent to composite. There is no inflammation. Reproduced with
permission from Cox CF et al.138 B, If restoration is not sealed from saliva, microleakage allows a tangle of bacterial colonies to proliferate
under composite resin, leading to pulpal inflammation. Reproduced with permission from Brnnstrm M.211
Hrsted and his Danish colleagues conducted a sim- Heys et al. of Michigan placed two microfilled com-
ilar study, preparing cavities in monkey teeth with a posites and a conventional composite in monkey teeth
remaining dentin thickness of only 0.3 mm.177 They as well.178 No cavity liner, acid etchant, or bonding
then placed both a chemically cured composite and a agent was used in cavities averaging 0.59 mm remain-
light-cured composite in these deep cavities. Half of the ing dentin thickness. At 8 weeks, 6 of 27 teeth were
cavities were lined with calcium hydroxide and half acutely inflamed.
were not. Pulp inflammation was generally related to Again, bacteria were indicted. They were found
microleakage (bacteria were found in all unlined cav- along the cavity walls of all teeth. There was no pene-
ities). The most pronounced inflammatory changes tration of bacteria into the tubuli, however. Pulp pro-
were seen beneath the pulpo-gingival corner of the cav- tection was undoubtedly afforded by an intact smear
itya common site for bacteria to accumulate and layer obstructing the tubuli in some cases. In spite of
penetrate the tubuli.177 this evidence, Heys et al. made a pitch for a calcium
Speculating on this finding, Hrsted et al. empha- hydroxide liner.178
sized the importance of carefully extending the protec- In spite of the suggestions that calcium hydroxide be
tive dentin liner to proximal and gingival walls as well used as a cavity liner, a number of dental scientists have
as the pulpal floor. They also urged care in acid-etching questioned its use under composite resins.179 Lacy
the enamel to prevent gaps at the enamel surface, which pointed out that calcium hydroxide should be used
open to microleakage.177 only in instances when extra pulp protection or stimu-
lation is needed.179 Even then, a thin layer of one of The lower pH of Prisma VLC Dycal evidently pre-
the newer hard setting preparations is indicated. This cludes pulp necrosis but still provides sufficient irrita-
allows for more depth and strength in the resin. tion to stimulate the formation of irritation dentin.
Calcium hydroxide, however, should be protected by a Stanley observed dentin bridging in all but one speci-
layer of glass ionomer cement.179 men in the study.182 Cavalite, with an almost neutral
The late Ron Jordan, one of North Americas fore- pH, has been shown in capping studies to produce a
most authorities on the clinical use of composite resins, dentin bridging and pulp reorganization. McComb
recommended glass ionomer cements, rather than cal- placed Cavalite first, as the best combination of
cium hydroxide, under composite fillings.180 If calcium strength, clinical handling and aesthetics.183
hydroxide must be used (in near exposures or actual Stanley and Pameijer warned that care must be taken
exposures), hard, light-activated calcium hydroxide not to bayonet dentin chips into the pulp or force the
should be used and then covered by a glass ionomer capping agent therein. Either or both will form a dou-
base. In very deep cavities, calcium hydroxide should ble bridge of dentin deeper in the pulp, and the
also be used under glass ionomers.180 Eventually, the trapped tissue will become nonvital. One must also
dentin bonding agents may completely replace glass make sure that the covering restoration is not lifted
ionomer cements in such situations. from the exposure site by intrapulpal edema or the
Calcium Hydroxide Resin, Light Cured. Because it bridge will not form against the pulp tissue.181
comes in a form of light-cured composite resin, calcium Glass ionomer cements, a formulation of resin and sil-
hydroxide will be discussed here as well. Stanley and icates, were developed in 1972, in England, by Wilson and
Pameijer studied just such a material, Prisma VCL Dycal Kent and termed ASPA (an abbreviation for aluminosil-
(L.D. Caulk Co., Milford, Dela.) which consists of calci- icate-polyacrylic acid).184 Since its original formulation,
um hydroxide and fillers of barium sulfate dispersed in a other acids have been added: itaconic acid to increase the
specially formulated urethane dimethylacrylate resin reactivity of the polyacrylic acid, tartaric acid to extend
containing initiators (camphoroquinone) and activators. the working time, and polymaleic and mesaconic acid to
The resin is activated by light in the wavelength range of improve the cements physical properties.
400 to 500 mm.181 Prisma VCL Dycal is similar to Cavalite Combining the strength, rigidity and fluoride
(Kerr Co.; Orange, Calif.), which also contains a glass release properties of a silicate glass powder with the
ionomer powder filler and 14% calcium hydroxyapatite. biocompatibility and adhesive characteristics of a poly-
Composite resin calcium hydroxide has a number of acrylic acid liquid, glass ionomer cements may be
advantages over regular water or methylcellulose-based characterized as strong, stiff, hard, materials that are
calcium hydroxide: dramatically improved strength, adhesive to calcified tissue, have low toxicity, and are
essentially no solubility in acid, and minimal solubility potentially anticariogenic.185 Various manufacturers
in water.181 To this can be added the control the clini- throughout the world were licensed to produce and
cian has over working time with any light-activated market the glass ionomers as both a filling/basing
resin that sets on command and reaches its maxi- cement and a luting cement.186
mum physical properties almost immediately.181 Initially, all of the testing of ASPA was for its physi-
Calcium hydroxide causes the deposition of minerals cal and chemical properties. By 1975, Klotzer had test-
essential to the repair of pulp exposures by the stimulation ed its biologic effect on pulps in monkey teeth and con-
that comes from its being a mild tissue irritant. It is neces- cluded that ASPA II was an irritant, but less so than sil-
sary, therefore, that the calcium hydroxide not be so tight- icate.187 The following year, Dahl and Tronstad found
ly bound in the resin that it cannot be released to act as an much the same.188 They also noted that toxicity dimin-
irritant. This is essentially what Stanley and Pameijer test- ished with setting time and that at 24 hours it was com-
ed for, comparing Prisma VLC Dycal against water-solu- pletely set and nontoxic.188
ble Advanced Formula II Dycal (L.D. Caulk Co.; Milford, In 1978, Tobias and Browne tested ASPA and con-
Dela.). They found the resin-based Prism VLC Dycal to be cluded that pulpal reaction to ASPA was similar to that
over three times stronger than the water-based Dycal and of polycarboxylate cements.189
its solubility in water to be less by half.181 In 1980, Cooper tested ASPA IV and ASPA IVA in
Concerning pulp response to light-cured Dycal, Class V cavities in premolars in humans, without a rub-
inflammation was of no consequence.181 This is in ber dam, and filled them with either ASPA IV, ASPA
contrast to regular Dycal, which caused a thickness of IVA, silicate, or ZOE. He found irritation dentin pro-
pulp mummification (chemical cautery) of 0.3-0.7 mm tecting the pulp and proved these materials to be mild
at the exposure sites.182 irritants, not toxic ones.186
Nordenval and colleagues also tested ASPA in etched glass with silver to produce a sintered metalglass com-
and unetched cavities, and after 70 to 90 days found posite called cermet.198 It is sold as Ketac-Silver
no inflammation under any of the cavities including (Premier-Espe; Norristown, Pa.), and McLean recom-
the two with pulp exposures.190 They also found no mended its use for very conservative cavity prepara-
bacteria in the cavities. tions wherein the cermet, bonding to both enamel and
Kawahara et al. found that [G]lass ionomer cement dentin, reformed a monolithic structure with the tooth,
has no irritant effect upon the living pulp, but polycar- returning it to its former strength.199,200 McLean had
boxylate and zinc oxideeugenol cement kept their irri- no comment about pulp irritability from cermet, and,
tating effect after setting.191 Meanwhile, in the United for the time being, one would cautiously assume it to
States, Pameijer et al. were testing glass ionomers in pri- be the same as regular glass ionomer cement.
mates and concluded that they were biocompatible to the The findings on glass ionomer cements presented
pulp and that a protective base (Dycal) was not deemed here may be summarized by saying that they are no
necessary.192 They also observed no bacteria on cavity more toxic, and to some extent less so, than other fill-
walls or within the tubules. When a similar study was ing or luting cements. They are recommended as a base
done without pressure and using Ketac-Cem (Premier or liner under composite resin fillings and amalgams. If
Dental; Norristown, Pa.) luting cement, Pameijer and handled properly and allowed to set without moisture,
Stanley found minimal pulpal response.193195 By 1984, they are strong, do not shrink, and resist dissolution by
Meryon and Smith were reporting fluoride release from either water, saliva, or acid. At this juncture, they have a
three glass ionomers, which they felt should serve as a decided advantage: they are the only cements that bond
protection against secondary caries but may initiate to dentin. To this a caveat must be added: If they are
some pulpal inflammation.196 used as a base under composite resin fillings, this bond
In 1987, Fitzgerald et al. evaluated three luting may be illusory. According to Garcia-Godoy, Although
cements, zinc phosphate, polycarboxylate, and G.C. glass ionomer adheres to dentin, the polymerization
Fuji glass ionomer (G.C. International, Japan/USA), for contraction of the composite bonded to it can break
bacterial leakage.197 Cultivable bacteria were found the original bond between the glass ionomer and the
under all three cements but significantly less than dentin, allowing microleakage.201
would be suspected from the stained bacterial layer If placed in deep cavities or over extensive crown
found later when all of the test crowns were eventually preparations, light-cured calcium hydroxide should
removed. At 10 days and 56 days, there was a significant first be used as a base under glass ionomers wherever a
decrease in the number of bacteria under glass thin remaining dentin thickness is suspected. This is
ionomer cement but a significant increase in bacteria especially true in crown preparations if immediate and
under zinc phosphate. Bacterial counts under polycar- lasting hypersensitivity is to be avoided. Before placing
boxylate remained about the same.197 glass ionomers, the dentinal tubuli must be well
Fitzgerald et al. blamed microleakage for this occluded to prevent either the pulpal flow of free poly-
increase in cultivable bacteria. They postulated, more- acrylic acid or the flow of dentinal fluid in the tubuli, a
over, that the observed microleakage might provide movement that brings on pain by hydrodynamic
enough fluid movement across the cut dentin to elicit a stretching or crushing of the odontoblasts. This is par-
painful response. They cited the hydrodynamic theo- ticularly true if anhydrous ionomers are used for they
ry of pulpal pain, small movements of fluid within draw the dentinal fluid away from the pulp, incurring
dentinal tubules causing pulpal pain197 (see chapter immediate and lasting hypersensitivity.193
7). They concluded that it is possible that glass All in all, glass ionomer cements are a valuable addition
ionomer cement had antibacterial actions (fluoride) to dentistry. They not only bond chemically to dentin (for
that reduced the number of viable bacteria but not the how long is not known), they also do not shrink or leave a
amount of fluid penetration.197 contraction gap between the cement and dentin.
It would appear that the presence of bacteria alone is Furthermore, they have a compressive strength of 28,000
not the prime cause of hypersensitivity, for if it were, zinc psi. On the other hand, they are technique sensitive. When
phosphate should be the most sensitive.197 Pameijer using them as luting agents, however, the areas close to the
and Stanley concurred in this observation, pointing out pulp should be covered with visible light cure (VLC) calci-
that bacteria could not be responsible for early inflam- um hydroxide. This protects the pulp in critical areas with-
mation, which is more likely caused by cement acidity.193 out losing the benefit of the bonding advantages. Stanley
To raise the abrasion resistance for glass ionomer pointed out that glass ionomer cements appear to be pulp
cements, McLean and Gasser in England combined the irritants mainly when used as luting agents.176
Preparation of the Cavity to Receive Composite from the cavity preparation.173 To this one might add,
Filling Materials. Before any glass ionomer cement bacteria in the smear layer as well.
or composite material is placed, elaborate preparations Initially, citric and phosphoric acids were recom-
must be made of the margins and surfaces of the enam- mended on both enamel and dentin, apparently with
el and dentin. Enamel rods are opened by acid etch- no thought given to pulp reactions* (Figure 4-40). This
ing. In spite of the many caveats about not using strong was followed by a flurry of research efforts purporting
acid on freshly cut dentin, some dentists remove the to show the deleterious effects of acid treatment of the
dentinal smear layer with 37 to 50% citric or phos- dentin.174,175,202208 In these experiments, a number of
phoric acid. factors may have contributed to the pulpal inflamma-
Etching Agents. Acid etching the enamel to tory response to acid on dentin, including strength of
improve bonding is a necessary part of the composite acid (50%),175 length of application time (up to 5 min-
technique. Based on the success of enamel bonding, it utes203,205), remaining dentin thinness,206 toxicity of
is also believed that etching the dentin will improve the ZOE test filling materials,131,138,207,208 and the irri-
bonding while cleansing and removing grinding tating effects of bacteria bathing the dentin through
debris, dentin chips, blood and denatured collagen microleakage under resin test restorations.138
But, gradually, the conventional wisdom regarding
dentin acid treatment appeared to turn to favor the use
of acids. Brnnstrm recommended acid etching
dentin and noted no lasting pulpal inflammation.209
Pashley stated that this seemingly extreme proce-
dure does not injure the pulp, especially if diluted acids
are used for short periods of time.210 White and Cox
reported that acid etching of vital dentin does not
cause pulp inflammation.211
Fusayama in Japan212 and Kanca213217 and Berto-
lotti218 in the United States popularized dentin acid
treatment, claiming no deleterious pulpal effects. An
important caveat, however, is the subsequent application
of a dentin bonding agent, thus eliminating microleak-
A
age. In histologic pulp studies in monkeys, testing the
true effects of acid conditioning but eliminating other
toxic irritants (ie, ZOE, microleakage, etc), White et al.
found that acid etching of vital dentin does not impair
pulpal healing when placed in deep Class V cavities.219
To remove the smear layer and its incorporated bac-
teria, Kanca used 37% phosphoric acid gel applied for
only 15 seconds.217 Others used 10% polyacrylic acid
(Smear clean/10, H.O. Denta, USA) for 10 seconds,205
10% citric acid (10-3 conditioner, Parkell Co.,
Farmingdale, N.Y.) for 10 seconds, 2.5% nitric acid, or
EDTA. These diluted acids, left in place for a short peri-
od of time, fall within Pashleys window of safety.210
As a matter of fact, Nakabayashi showed that overetch-
ing the dentin weakens the bond between adhesives
B and the dentin.220
Figure 4-40 A, Cross-section of dentin tubules in the floor of a One must know that commercial etchants are sel-
cavity treated with 50% citric acid cleaner for 2 minutes. Openings dom marketed as such but are euphemistically called
are unobstructed and enlarged. Note absence of tubular contents conditioners or primers. Whatever they are called, it
microcrystalline debris or odontoblast processes. Reproduced with
permission from Cotton WR and Sigel RL.203 B, Severe inflammato-
ry response and necrosis in pulp 7 days following acid etch of dentin *One thinks of these etching acids as being highly acidic. Actually,
for 1 minute and filled with composite. Dentin depth at horn 1.1 they are virtually the same pH as fresh lemon juice, pH 1.4. They
mm. (Courtesy of Dr. Y. Hirai and Prof. T. Ishikawa, Tokyo, Japan.) range from pH 1.3 to pH 2.6.
goes without saying that the dentin surface, cleaned of but, unfortunately, has a very low compressive strength,
the smear layer and its bacteria, and the dentinal allowing the filling to be crushed into it.
tubules opened, must then be protected by a cavity There are other variations of pulp-stimulating
liner or base or, better yet, by a dentin bonding agent cements that enjoy wide use, particularly in Europe: cal-
that adheres the final filling to the tooth structure, cium hydroxide cements containing corticosteroids
eliminating microleakage. (Ledermix, Lederle, Germany) or sodium and potassium
Cavity Liners, Bases, and Dentin Bonding Agents. salts (Calxyl, Otto Co., Germany).
When one usually thinks of cavity liners, the varnishes Baratieri and his colleagues found that Ledermix
and resin monomers come to mind, including chemi- (calcium hydroxide cement containing triamci-
cals such as copal, polyvinyl, cyanoacrylate, the acrylics, nolone, a corticosteroid) depresses the activity of the
and procion dye liners.174 But the list is longer. It should odontoblasts and thus slows and deters irritation
also include cements: zinc phosphate, ZOE, glass dentin apposition.222 The findings were comparable
ionomers, and polycarboxylate, as well as calcium to those with dexamethasone (Decatron, Merck-
hydroxide, particularly the new light-activated resin- Sharpe & Dohme; Hoddeson, Hertfordshire, U.K.),
type calcium hydroxide. Some of the new liners contain another corticosteroid,222 Langeland et al. noted ear-
ingredients such as glutaraldehyde, hydroxyethyl- lier,223,224 as had Mjr and Nygaard stby.225 Calxyl,
methacrylate (HEMA), oxalate salts, and oleic acid. The a calcium hydroxide mixture, in contrast to Ledermix,
dentin bonding agents may also be thought of as cavity allows the maintenance of normal dentinogenesis by
liners, even though their initial responsibility is to bind protecting the pulp against the irritation from opera-
final restorations, metal, porcelain, or resin to dentin. tive procedures.222
What are the indications for using a base or a cavity Finally, time-honored zinc oxyphosphate cement is
liner? One might first suggest that a liner or base protects an excellent base under inlays and amalgams, as is poly-
the pulp by acting as a barrier against thermal sensitivi- carboxylate cement. For strength of the final covering
ty and against microleakage. Liners should also reduce restoration, however, these bases should not exceed 1.0
or eliminate dentin permeability. Some, like calcium mm in thickness.226 In the long run, both cements have
hydroxide, act as mild stimulants to produce protective limited pulpal irritation qualities.
dentin. Others, such as ZOE, lull the pulp to sleep. Liners. Time-honored (but not very) copal var-
Since these materials are applied directly onto nishes (Copalite, H. J. Bosworth Co.; Skokie, Ill.) may be
dentin, they should be nontoxic, nonirritating and used under zinc oxyphosphate cement bases or directly
cause no irreversible changes to the pulp.221 At the under amalgams but never under composite resins or
same time, the liner or base must have sufficient com- glass ionomer cements. As Pashley and Depew pointed
pressive strength so that it will not collapse or crush out, Copalite reduces permeability to some degree. But
down under biting pressure. If it does, it will allow the Copalite residue is hydrophobic and tends to lie on top
flexion of the major filling material above it, leading to of cavity surfaces much like a gasket.227 Although ini-
distortion, marginal opening with eventual breakage of tially reducing microleakage, Copalite tended to permit
the marginal seal, or possibly fracture of the filling increased leakage after three months.227 It has been
material itself, a cusp, or both. Flexion also causes pul- shown that pinholes develop over each open tubule as
pal pain. In addition to being biocompatible with the fluid pushes through (Figure 4-41).
pulp, the base or liner must be chemically compatible Around 1980, the methylcellulose-based liners were
with the final filling material as well. introduced and found to be efficacious as pulp protec-
For all of the above reasons, ZOE is not a good base. tants and also highly compatible under composite
In the long run, it is not a biocompatible material. It is resins.228 Stanley recommended that a thin coating of
also soft, easily compressible, and chemically antagonistic calcium hydroxide should be used under most resins
to resins, and if microleakage occurs, ZOE washes out. (personal communication, September 1, 1981).
Calcium hydroxide, on the other hand, is an ideal A dentin sealant, Barrier, also became available. A
pulp protectant but should be used only where indicat- 50/50 polymer compound of dimerized oleic acid with
ed, in a very thin layer, over near or true pulp expo- ethylenediamine, it has an extremely high molecular
sures (under dam) and should be the light-activated weight and will completely block dentin tubuli.
resin calcium hydroxide that features a high compres- (Composite resin monomer has a very low molecular
sive strength. weight.) Tested for biocompatibility, Barrier was
Regular aqueous or methylcellulose calcium hydrox- found to be completely nontoxic to the pulp at the end
ide also fails as a base. It is biocompatible with the pulp of 1 week.229
Longitudinal studies of these new products are, of acid for 10 seconds.233 As far as 4-META/MMA-TBB
course, limited. Recently, however, Summitt and his itself is concerned, Japanese researchers compared the
associates presented the results of a 4-year study com- new material (in dog dental pulp studies) with another
paring 60 complex amalgam restorations in vital molar dentin bonding agent and against controls of glass
teeth, 30 teeth in each cohort. In half of the cases, pins ionomer and polycarboxylate cements.235 They found
were used for retention. In the other half, that the effects of the dentin bonding agents on the
Amalgambond Plus was used for retention. At the end dental pulp were less harmful than the classic
of 4 years, the bonded restorations were performing as cements. Four other Japanese research groups found
well as the pin-retained restorations, except three of essentially the same, that the system was found to be
the pin-retained restorations suffered significant tooth safe and pulp compatible.236238 Toshiaki et al. stated
fracture adjacent to the restoration.234 that the C & B Metabond was found to cause signifi-
To achieve true dentin adherence with a dentin cantly less inflammation than either polycarboxylate or
bonding agent, the smear layer must be removed. For zinc phosphate cements.239
this procedure, 10-3 is used: 10% citric acid and 3% Pashley pointed out that if bonding agents do not
ferric chloride applied for 10 seconds. When the completely polymerize, free monomer may irritate the
base/catalyst, 4-META/MMA-TBB, is applied to the pulp, especially in deeper cavities.233 Prinsloo and
cleaned dentin surface, a hybrid layer of dentin and Vander Vyver in South Africa found that C&B
resin forms that is very adherent to the tooth. This Metabond shows a much higher degree of polymeriza-
bonding is a physical entanglement between the resin tion than dual-cure [self-cure and light-cure]
and the collagen fibers of the dentin matrixcollagen cements70% vs. 30% at 24 hours.240
that has been frayed by the smear removal. The dentin Testing for any leakage cytotoxic components of five
bonding agent also flows into the tubules and mechan- adhesives, Tell and his associates found that
ically locks there (Figure 4-42). 4-META/MMA-TBB demonstrated the least cytotoxic
If the dentin is completely covered, and if this new leachable components by producing no cell death after
acid-resistant, hybrid layer will last forever, the problem day 5.241 Four other products tested leaked toxic com-
of microleakage would be solved and the pulp would be ponents for 2 years.243 Cox et al. and Yamami,
everlastingly protected from external attack. Time (and Miyakoshi, and Matsura and their colleagues, in
longitudinal, intraoral, clinical studies) will tell. Japan,243245 also reported 4-META as less toxic.
Placement. As far as immediate irritation from the On the basis of this evidence, one might conclude
placement procedures of 4-META/MMA is concerned, that this new dentin bonding agent (serving as an
there is evidence that pulpal irritation is minor and example of what is sure to evolve) is no more toxic on
brief. As previously stated, there does not appear to be application than any other dentin bonding agent or
any lasting pulpal damage from the use of 10% citric composite resin. Furthermore, its acid-resistant nature
A B
Figure 4-42 A, Dentin bonding agent 4-META penetrates tubules and bonds to collagen. The dentin is partially decalcified to show deep
tubular penetration. Adhesive and collagen merge at the surface to form a hybrid layer. B, After composite resin (R) was bonded to dentin,
the section was decalcified in acid, demonstrating acid-resistant hybrid layer (H). Decalcified dentin (DD) shows characteristic resin tags.
Reproduced with permission from Nakabayashi N. Adhesive dental materials. Trans. Internat. Cong. on Dent. Mater., Acad., Dent. Mater.,
November 1989, p. 70.
and its dentin (as well as enamel, cementum, metal, Cobb.248 Stanley and Bowen247 found that so little pul-
ceramic, and resin) bonding capabilities might well be pal pathology is in accord with the concept that the ferric
the preventive panacea to future pulp survival. oxalate and other solutions bring about an obturation of
Tubule Blockage Agents. In Australia, Al-Fawaz the dentinal tubules without releasing noxious compo-
and his researchers showed the transport of two com- nents. After testing in humans, Bowen et al. concluded
ponents of a composite resin, HEMA and Bis-GMA, that the experimental material is safe and effective.249
through the tubules of acid-etched dentin into the pulp One problem emerged with ferric oxalates, however:
during the crown cementation.246 If toxic enough to in some teeth, a marginal stain developed. This led to a
sting a stressed pulp, either of these chemicals could search for other oxalic compounds, and aluminum
start an inflammatory reaction that might not resolve. oxalate emerged as acceptable. Once again, the
One way to ensure pulp protection from potentially Bowen/Stanley group reported no displacement of the
toxic products is to block the dentinal tubules. This can odontoblasts and only slight to no inflammatory
be neatly accomplished by using oxalates on the dentin response. They concluded that the aluminum oxalate
surface. Remember the gritty feeling in your mouth material appeared safe for human clinical trials.250
when you eat spinach or rhubarb? This is the same At the US National Bureau of Standards, both ferric
processthe oxalates precipitate calcium from the sali- oxalate and aluminum oxalate were tested for
va in the one case or from the dentinal fluid in the other. microleakage against two commercial bonding agents.
Pashley tested 3% half-neutralized oxalic acid plus After being thermocycled for 7 days, all four materials
30% dipotassium oxalate for efficacy in plugging the exhibited gingival microleakage, although the oxalates
tubules and blocking dentin permeability.227 The insolu- had lower microleakage scores than the two commer-
ble calcium oxalate crystals that formed in the tubules led cial systems tested.251
to a 98.25% reduction in dentin permeability, lower If the dentin can be rendered totally impermeable,
than any other liner previously tested (Figure 4-43).227 then the toxicity to the pulp of any product placed on
Later, Stanley et al. tested in monkeys the pulpal effects of the fresh dentin surface does not matter. The tubule
applying ferric oxalate hexahydrate (6.8% aqueous solu- blocking agent, of course, cannot interfere with dentin
tion, pH 0.84) in Class V cavities for 60 seconds, rinsed adhesion or be so toxic itself that it causes pulp inflam-
and air-dried.247 This technique was previously devel- mation. Leinfelder pointed out that sealing the dentin
oped by Bowen (the father of composite resins) and surface with an adhesive bonding agent that produces a
A B
Figure 4-43 A, Dentin treated with 30% potassium oxalate reveals calcium oxalate crystals that closely match the size of tubule orifices.
Note penetration of crystals into tubules. B, Higher magnification of A reveals strands of material connecting crystals to walls of tubules.
Dentin permeability is reduced by 98.25%. Reproduced with permission from Greenhill JD, Pashley DH. J Dent Res 1981;60:686.
hybrid layer effectively stops the fluid flow and basi- and his associates applied sodium fluoride by ion-
cally eliminates postoperative sensitivity.252 tophoresis to exposed dentin on root surfaces of young,
permanent dog teeth.260 Two levels of current were used:
Disinfectants therapeutic levels and five times therapeutic levels. They
The empiric habit of dentists attempting to sterilize found that There were no demonstrable histologic or
prepared cavities before inserting a restoration is time ultrastructure alterations of the underlying pulp
honored. In spite of this, Black did not recommend In spite of this surface evidence, it is questionable
that an antibacterial cavity agent be used, although his whether sodium fluoride should be precipitated by
contemporaries were using caustic drugs.253 Dorfman electrolysis on freshly cut dentin. By measuring
et al. and Stephan also questioned the value of the beta-ray emissions from preparations from teeth sub-
so-called sterilization of the cavity.254,255 Many of the jected to electrolytic action of radioactive sodium chlo-
drugs were a poor choice. ride, Briscoe et al. demonstrated that the halogen was
Silver Nitrate and Phenol. Seltzer et al. found sil- driven completely to the pulp.261
ver nitrate to be devastating to the pulps of monkey
teeth when applied to shallow cavities.5 They also Desiccants
described pulps in a severely disturbed condition Alcohol, Ether, and Others. Time-honored desic-
months following the application of phenol to a deep cants, such as acetone, ethyl alcohol, ether, and chloro-
cavity. As late as 6 months following the application of form, are probably not damaging to the pulp by their
these drugs, recovery was questionable. Obviously, chemical action but rather by upsetting the physiologic
these older drugs were far too toxic to be used for so- equilibrium of the dental interstitial fluid. Use of the
called cavity sterilization. desiccants is also invariably followed by a blast of air. The
In more modern times, Brnnstrm et al. strongly irritation from dehydration must be indicted as well.
emphasized the importance of cleansing the prepared Products such as Cavidry (Parkell Co.; Farmingdale,
cavity. They pointed out that bacteria can survive in N.Y.) or Cavilax (Premier Dental; King of Prussia, Pa.)
grinding debris which forms a smear layer 2 to 5 microns may be used for the rapid drying, cleaning or degreas-
thick that adheres to the prepared surfaces and cannot be ing of intracoronal or extracoronal tooth prepara-
removed by a water spray. They claimed that this layer tions.262 The active ingredients are methylethylketone
of bacteria appears to be the main cause of injury to the and ethyl acetate. These products are especially useful
pulp observed under restorative materials149 in removing the light film of oil and moisture left by
Brnnstrm and Nyborg recommended that a the air rotor handpiece. Cavidry evaporates in seconds
microbicidal, surface-active cavity cleanser, Tubulicid without a blast of air. It should not be used in close
(red label; Tublicid Red [chlorhexidine digluconate proximity to the pulp, however.
dodecyldiaminoethyl-glycerine and sodium fluoride],
IDIOPATHIC CAUSES
Dental Therapeutics AB, Sweden) be scrubbed in the
cavity with a cotton pellet and then left for 1 minute Aging
before removing it and air-drying the cavity for 5 sec- Inevitable retrogressive aging changes take place in
onds.148 Surfaces treated in this manner have most of the pulp as in all other body tissues. The decreased
the smear layer removed without opening the outer ori- numbers and size of cells and increase in collagen fiber
fices of the dentin tubuli plugged with microcrystalline content have long been noted as an age change.263 The
smear. Removing the bacteria-laden smear layer with constant recession of the normal pulp and its produc-
10% polyacrylic acid (for 10 seconds) or 10% citric acid tion of secondary and irritational dentin are as certain
(for 10 seconds) is another very acceptable method. as death and taxes.
Sodium Fluoride. The irritating effects on the dental Seltzer et al. pointed out that atrophy of the pulp nor-
pulp of sodium fluoride were noted early on by Lefkowitz mally occurs with advancing age.63 They described these
and Bodecker256 and by Rovelstad and St. John257 but dystrophic changes as the burned out appearance of an
denied by Maurice and Schour.258 Later, Furseth and exhaustion atrophy. This aged pulp seems less likely to
Mjr applied 2% sodium fluoride for 2 minutes in fresh- resist insult than the young, virile pulp, although there
ly prepared dentin cavities in young human teeth and is a paucity of published evidence to prove this.
found virtually no adverse pulp reaction.259
The use of the fluorides as a desensitizing agent on the Internal Resorption
external tooth surface is probably well within reason, Although internal resorption may occur in chronic
even when precipitated by electrolytic action. Walton pulpal inflammation, it also occurs as an idiopathic
dystrophic change. Trauma in the form of an acciden- resorption.264 The researchers found that internal resorp-
tal blow, or traumatic cavity preparation, has often tion progresses more rapidly in deciduous teeth. In addi-
been indicted as a triggering mechanism for internal tion, they were surprised to learn that 11 of the 13 teeth
resorption. In this event, the metaplastic area of the exhibited caries as the resorption triggering mechanism,
pulp might develop from a localized hemorrhage. and that only 2 of the teeth had been traumatized.
Dentin destruction follows (Figure 4-44). Active internal resorption was found in all teeth. It
An outstanding report from the Karolinska Institute in was characterized by large multinucleated dentin-
Sweden dealt with 13 teeth extracted because of internal oclasts in resorption lacunae on the pulpal dentin sur-
A B
C D
Figure 4-44 Extensive internal resorption apparently triggered by iatral causes. Normal condition of teeth
prior to crown preparation is seen in before radiographs (A and B). Development of internal resorption from
high-speed preparation without water coolant is seen 1 year later (C and D). (Courtesy of Dr. Dudley H. Glick.)
face (Figure 4-45). The nuclear domains of these cavities differed markedly from normal pulp tissue and
peculiar dentinoclasts were covered with numerous appeared to have been replaced by ingrowing peri-
microvilli. Microscopically, these cells were similar to odontal connective tissue or had undergone metaplasia
the cementoclasts observed in external root resorption of such tissue. The process appeared to alternate
(Figure 4-46). between resorption of dentin and apposition of miner-
In all teeth, there were varying degrees of inflamma- alized tissue.264
tion, and in all but two teeth, bacteria could be detect- Brooks reported an unusual case of internal resorp-
ed where the coronal pulp tissue was necrotic. tion in the crown of an unerupted lower second pre-
Odontoblasts could not be observed in any of the molar in an 11-year-old boy.265
teeth and predentin was rarely seenThe tissue that
had replaced the normal pulp resembled periodontal External Resorption
membrane connective tissueMineralized tissue One cannot say that external root resorption is a pulp
resembling bone or cellular cementum partly outlined dystrophy for its origin lies within the tissue of the peri-
the pulp cavity in all teeth.264 odontal membrane space. Common to all forms of tooth
Based on the histochemical similarity, the Swedish resorption is the removal of the mineralized and organ-
researchers surmised that internal resorption is engi- ic components of dental tissues by clastic cells. In the
neered by clastic cells similar or identical to osteo- case of external root resorption, this may be a transitory
clasts. They also concluded that the tissue in the pulp response as in surface resorption266 that may occur fol-
lowing trauma or orthodontic tooth movement.
All other forms of external root resorption are pro-
gressive and may have important implications from a
pulpal viewpoint. Inflammatory (infective) root
resorption266 usually results from luxation or exarticu-
lation injury and is caused by the transmission of bac-
terial toxins from a devitalized and infected pulp via
dentinal tubules to an external root surface that has
previously been partly denuded of the normally pro-
tective cementum-cementoid layer by surface resorp-
tion. Clastic cells are stimulated to the region by
inflammatory mediators such as prostaglandins and
cytokines, which are libertated as part of the inflamma-
tory process.
B
Figure 4-45 A, Internal resorption lacunae caused by dentin- Figure 4-46 Dentinoclast (D) on dentin surface. The cell surface
oclasts. B, Scanning electron micrograph of rough and uneven is covered with numerous microvilli. Cells also present:
dentin surface with numerous resorption lacunae. Reproduced with macrophage and erythrocytes. Reproduced with permission from
permission from Wedenberg C. JOE 1987;13:255. Wedenberg C and Zettesqvist L.264
A diagnosis of inflammatory root resorption, which type of resorption, more extensive lesions require non-
is characterized radiographically by bowl-like radiolu- surgical root canal therapy and resorption treatment if
cencies in both the tooth and the adjacent bone, is also the tooth is to be retained.
diagnostic of an infected and probably totally necrotic When external resorption destroys enough dentin to
pulp. Early root-canal dbridement and medication reach the pulp, pulp inflammatory changes begin. The
with calcium hydroxide paste is recommended. same infection problem also develops when internal
Prophylactic pulpectomy is also recommended in cases resorption destroys enough tooth structure to reach the
of trauma for which there is a high expectation of pulp sulcus. Continued resorption takes place until the pulp
death, such as a replanted or intrusively luxated tooth either is removed or becomes necrotic.
with a mature apex. Intracanal medication with calci- Researchers at Kings College in London reported a
um hydroxide paste will generally control potential case of multiple idiopathic external resorption involv-
resorption. ing 14 teeth.269 Although electric pulp testing gave a
Replacement resorption266 occurs when there has vital response in all affected teeth, radiographs showed
been death of the periodontal ligament cells. Clastic extensive apical root resorption in both arches (Figure
cells, derived from the adjacent bone, cause a progres- 4-47). The teeth were symptomless and nonmobile.
sive replacement of dentin by bone. Inflammatory Although the patient was a morphine and heroin
(infective) resorption may be superimposed on addict and had had hepatitis A, he did not have
replacement resorption. Ultimately, the tooth is hypoparathyroidism or pseudohypoparathyroidism,
replaced by bone as it is progressively resorbed. diseases that lead to root resorption.
In the case of extracanal invasive resorption,267 also
termed invasive cervical resorption by Heithersay,268 Hereditary Hypophosphatemia
the pulp remains unaffected until late in the process An unusual and rare cause of pulpal dystrophy occurs
owing to an apparently thin and resorption-resistant in individuals afflicted with hereditary hypophos-
layer of dentin and predentin. This separates the pulp phatemia. This disease, which results in dwarfism and
from the ingrowing tissue that is initially fibrovascular tackle deformity, was formerly called refractory rick-
in character but becomes a fibro-osseous type of tissue. ets or vitamin Dresistant rickets. It is characterized
If exposed to the oral cavity, the pulp will be invaded by dentally by the huge pulps (Figure 4-48) and incom-
microorganisms. Although pulp vitality can be main- plete calcification of the dentin. The pulps in the teeth
tained if there is early diagnosis and treatment of this of these dwarfs appear to be fragile and succumb to
A B
Figure 4-47 Idiopathic external root resorption leading to pulpal involvement in maxillary second
molar, 1 of 14 teeth so affected. Reproduced with permission from Pankhurst CL et al.269
A B
D
Figure 4-48 Unusual pulp dystrophy seen with hereditary hypophosphatemia. Incomplete calcification of dentin and huge pulps leave these
teeth vulnerable to pulp infection and necrosis. A, Adult maxillary incisors at age 13. Note huge pulp. B, Mandibular incisors have been trau-
matized and pulp necrosis has developed. C, Huge pulps seen in premolar and molar teeth. Pulp of the first molar later became necrotic. D,
Same pulp size and shape are apparent in deciduous dentition. Diagnosis of condition could have been made at this stage from dental radi-
ographs. Early vitamin D therapy might have prevented dwarfing.
what would normally be minor irritating stimuli. In disease (HBD) and X-linked hypophosphatemia
one case, the patient had 11 pulpless teeth that required (XLH).270 Although victims of HBD and XLH share
endodontic treatment. similar dental abnormalities (large pulp spaces and
A report from Montreal pointed out that two differ- pulp necrosis), patients with XLH have severe maloc-
ent diseases are operative in producing this syndrome, clusions as well. Unfortunately, the dental abnormali-
namely autosomal dominant hypophosphatemic bone ties are not prevented by early systemic treatment.270
From Holland, a study of 22 family members, blood Human Immunodeficiency Virus and Acquired
related to a young woman exhibiting the characteristic Immune Deficiency Syndrome
signs and symptoms of hypophosphatemia, revealed Dental pulp tissue from a patient with acquired
several others who also had dental abnormalities. Of immune deficiency syndrome (AIDS) was examined to
these, however, only one sister fulfilled the biochemical determine the presence of human immunodeficiency
criteria for the disease.271 Biochemical examination of virus (HIV). The results found a high concentration of
an extracted tooth from this sister showed phosphate proviral HIV DNA.276 Fibroblasts have been impli-
and alkaline phosphatase values that were 7 to 10 times cated as a major reservoir for HIV in the body.277
lower than normal.271 Glick et al. suggested that other viruses, such as hepati-
Sickle Cell Anemia tis B, may also reside in the pulp.276
Sickle cell anemia, a genetic disorder characterized by THE FUTURE
an abnormal hemoglobin molecule which distorts the Pulp death seems to be on the increase, or perhaps only
erythrocyte into sickle-shaped cells, has been indicted an apparent increase owing to an awareness of the
as a cause of pulp death.272 Three cases exhibiting peri- value of the treated pulpless tooth. With routine exam-
radicular radiolucent areas have been reported. One ination and early treatment, with a cautious, temperate
patient had five noncarious, nontraumatized teeth approach to all restorative procedures, and with a sen-
involved. The sickle cells are suspected of compromis- sible use of filling materials, the dentist can prevent a
ing the microcirculation of the pulp. great deal of pulp death.
Herpes Zoster Infection Prevention of Pulp Injury
Goon and Jacobsen have reported a case of multiple In 1969, the American Dental Association (ADA)
pulp deaths caused by herpes zoster infection of the reported that American dentists extracted 56 million
trigeminal nerve.273 Immediately after suffering fifth teeth, placed 213 million fillings, made 4 million
nerve shingles, the patient developed a postzoster bridges and 10 million complete and partial dentures,
infection complex, that is, prodromal odontalgia, pulp- and completed 9 million root canal fillings. All of these
less teeth, neuralgic and facial scarring. The causative 292 million cases of dental therapy (only a fraction of
agent is varicella-zoster virus residing in the ganglion the dentistry being done today) had a direct relation to
cells sometime after a primary varicella (chickenpox) the dental pulp and testify either to its insult and injury
infection. Because the pulp contains terminal nerve or its disease or loss.278
endings, it is speculated that the reactivated virus trav- That some of this injury might have been prevented
els the length of the nerve and infects the pulp vascula- seems apparent. Caries alone probably accounted for
ture, leading to infarction and pulp death. Gregory et most of this dental treatment. Impact trauma undoubt-
al. also reported such a case,274 as did Lopes and his edly accounted for a large proportion as well. That vir-
associates in San Paulo, Brazil275 (Figure 4-49). tually unspoken third cause, dentistogenic (iatro-
A B
Figure 4-49 Herpes zoster (shingles) of the maxillary branch of the trigeminal nerve. A, Multiple vesicles on the face and involving the right
eye 4 days after initial visit. B, Ten days after diagnosis. Lesions follow distribution of the fifth nerve. The patient recovered in 1 month.
Reproduced with permission from Lopes MA, et al.275
genic), accounted for an embarrassingly high percent- vated using a slower speed handpiece (160,000 rpm or
age of the pulp injury and death reflected in the ADA less) and new carbide burs. Aggressive tooth prepara-
report. The University of Connecticut reported, for tion should be accompanied by supplemental water
example, that previous restorative treatment was the spray from a syringe with a constant focus on the
major etiologic factor leading to root canal therapy.279 rotary instrument.91 Coarse diamonds may be used
There are many day-to-day insults levied against the with air-water spray for gross reduction. Fine diamond
pulp that can be prevented: (1) depth of cavity and instruments or carbide burs are recommended for final
crown preparation, (2) width and extension of cavity smoothing of the tooth preparation.92 To aid visibility,
and crown preparation, (3) heat damage and desicca- smoothing of finish lines and fine detail may be done
tion during cavity preparation, (4) chemical injury with only air as a coolant. All tooth preparation should
through medicaments, (5) toxic cavity liners and bases, be accomplished using intermittent 10 to 15-second
(6) toxic filling materials, and (7) prevention of contact with the tooth.91
microleakage. Also damaging is the custom of preparing cavities
Depth and Width of Cavity Preparation. Extreme under a constant blast of air directed by an assistant.
pulp trauma results when the pulp is closely Here again, the desiccation of the dentin (and eventual-
approached or the dentin is extensively removed. ly the pulp) is most damaging. Odontoblastic nuclei and
Overcutting cavity preparations, whether or not the even erythrocytes can be seen microscopically, virtually
pulp is exposed, are undoubtedly one of the greatest sucked up into the desiccated tubules. Add to this
insults to the pulp. It should be quite obvious that damage the toxic effects of medicaments, liners or bases,
full-crown preparations damage every single coronal and filling material to give the pulp the coup de grce.
odontoblast. Before one cavalierly decides on full cov- Chemical Injury through Medicaments Applied to
erage for a tooth, if a less extensive restoration will do, the Dentin. One could say that pulp injury from chem-
the latter should be a standard preventive considera- ical irritants can best be prevented by not applying chem-
tion. When elective, shallow preparations are always the icals to the dentin. This prohibition refers to silver nitrate,
wiser choice over deep preparations. The integrity of phenol, alcohol, ether, acetone, thymol, fluoride, and
the pulp is affected as rotary instruments approach the cyanoacrylate, to name a few irritants. Corticosteroids
predentin, not just because of the immediate pulp may be the exception to the rule. Van Hassel and McHugh
damage but also because of the proximity of toxic fill- reported that the ability of prednisolone to suppress
ing materials. Udolph et al., for example, found that inflammatory vascular changes can prevent
composite filling materials would not irritate the pulp pressure-induced venous collapse beneath deep cavity
if 2 mm of dentin remained between the pulp and the preparations.283 On the other hand, one should not
filling.280 Although it is generally true that the risk of place false hope on cortisone to suppress all inflamma-
pulp damage diminishes with increasing distance,281 tion. It has been shown that inflammation will continue
there is no sacred distance beyond which no damage in the pulp despite the application of corticosteroids,
occurs. The surface width of the cavity may be as alone or in combination with other medicaments,30 if
important as the depth. In fact, a cut into the dentin pulp inflammation has passed that point of no return.
exposes the pulp to a variety of exogenous irritants. Cortisone reduces pain, but this may lull the dentist and
Heat Damage and Desiccation during Cavity patient into a false sense of security.
Preparation. The damage that results when Cavity Liners and Bases. The very products made
high-speed rotary instruments are used, without an to protect the pulp might well be the toxins that bring
adequate water coolant, has been well documented by about its demise. Spngberg and colleagues have shown
Takahashi, who induced acute pulpal inflammation by that the commonly used cavity liners may be more
cavity preparation without water spray, using a high- cytotoxic in vitro against HeLa cells than the compos-
speed carbide bur at 400,000 rpm.282 ite filling materials they are to protect against.284 It is
Goodacre summarized it best when he stated that reasonable to believe, they said, that the early irrita-
[T]o minimize the thermal effects, tooth preparations tion is caused by the solvent of the liner, which might
should be performed using an ultra highspeed hand- soon dissipate by evaporation.
piece (250,000400,000 rpm) with an air-water spray Cavity liners have another disadvantage as well. As
from multidirectional water ports. Water flow rate they cure against the dentin surface, pinholes develop
should be at 50 ml/minute and the water should be reg- that lead directly to the open tubules. Attempts at
ulated to be below body temperature (ideally 3034C). building up layers of the liner by multiple applications
Deeper parts of the tooth preparation should be exca- will not solve the pinhole problem. The toxic chemical
in the restorative material leaks directly through to the pulp inflammation? One cannot avoid them as a pre-
tubules to irritate the pulp (see Figure 4-41). Spngberg ventive measure for they have no substitutes for esthet-
summarized it simply: For pulp protection, a base is ic anterior restorations. One can only say, Use a prop-
necessary.284 er protective base or liner, one that covers all of the
In view of the fact that some cavity liners have been exposed dentin surface in the cavity. Care must also be
shown to be ineffective as well as toxic, it follows that taken in drying the dentin even before placement of the
their use cannot be recommended routinely as a pre- base. If desiccation precedes the introduction of any
ventive measure. Cement bases, on the other hand, can cement base, the irritant components of the base will
serve to prevent the toxic and/or thermal damage that replace the tissue fluid in the tubules, and the pulp
may be generated by filling materials. The most com- reactions will be more severe than if care is taken dur-
mon bases are oxyphosphate of zinc cement, polycar- ing surface drying.
boxylate cement, and ZOE. All three have been shown Biocompatibility and Postoperative Sensitivity.
to be irritants to the pulp, especially ZOE, but the two Under this title, the Council on Dental Materials,
other cements may prevent greater damage from other Instruments, and Equipment of the ADA issued an
more toxic fillings. important report in 1988.288 It deals with the perplex-
Placing a cement base may lull one into a false sense ing problem that has been detailed in the preceding
of security. The usual thought is protecting the pulp sections of this chapter. Although there are data to
floor of a cavity, but it is easy to forget that if the smear indicate that these materials are biocompatible, there
layer is removed, all open dentinal tubules, even those
are also reported cases of postoperative sensitivity
on the walls, are connected to the pulp and may serve
when restorations involve the use of composite resins,
as toxic conduits. Pulp floor cement bases were devel-
dentin bonding agents and glass ionomer cements.
oped for thermal protection but serve today as only
This report enlarged on and updated the Council
partial protection against noxious chemical fillings. If
report of 1984.289
in doubt, cover all of the dentin. Baume and
As before, the report blamed microleakage, bacteri-
Fiore-Donno suggested that in very deep preparations,
al invasion, and hydraulic pressure for pulp discom-
a base containing calcium hydroxide best protects
beneath composite resin restorations.285 Aqueous or fort. Added in 1988 was pain caused by shrinkage
methylcellulose calcium hydroxide bases, however, do stresses during curing of resins. Dentin permeability
not adapt well after curing, even if applied sufficiently might also be included as a culprit.
thick to be immediately impenetrable. Through Microleakage and Bacterial Invasion. New studies
microleakage, irritants may then work around the calci- on these associated problems are emerging. As previ-
um hydroxide bases to reach the open tubules.286 ously stated, initial leakage under amalgams is exten-
Light-cured, resin-based calcium hydroxide cement/ sive, but with time, a marginal seal is effected, pre-
liners are preferable and highly recommended. sumably due to the formation of corrosion products
Cement bases have one other bonus: they block under the amalgam.155
open tubules from bacteria and their noxious by-prod- The effect on microleakage under amalgams by
ucts. Dickey and colleagues found severe pulp necrosis removing the smear layer has also been treated.287
under a composite restorative material only when a Researchers in South Africa found that cavities with-
bacterial plaque had formed on the cavity floors.172 out smear layers displayed significantly improved seal-
Bacterial entree was gained from marginal microleak- ing properties. They contend that the smear layer is
age or cavity contamination prior to filling. The nox- unstable and leaches out.290
ious role of bacterial plaque under restorations was An English group studied microleakage under a
confirmed by Brnnstrm and Nyborg.287 Spngberg range of filling materialssilicate, zinc phosphate,
and colleagues recommended a base for pulp protec- methylmethacrylate, glass ionomer, and ZOEand
tion from microleakage.170 Unfortunately, bases of found no bacteria under 77% of the cavities filled in
polycarboxylate cement, which is touted as being adhe- humans.291 In the remaining 23%, the correlation
sive, actually allow bacterial plaque to form on the cav- between the amount of inflammation and bacterial
ity floor under composite materials. More recently, microleakage for all materials was statistically signifi-
dentin bonding agents have been found to reduce or cant. While blaming microleakage and bacteria for
eliminate this problem. pulpal inflammation, they further contended that
Filling Materials. What more can be said about chemical toxicity from the materials themselves is only
the noxious role toxic filling materials might play in of minor importance.291
Marginal Fit. Finally, one would be safe in saying tects the pulp by plugging the tubules, preventing ingress
that the integrity of marginal fit of the restoration, be it a of bacteria and their toxins as well as chemical toxins
crown, temporary crown,169 inlay, or amalgam, is most (Figure 4-50). On the other hand, if it is removed, it
essential in preventing leakage. This applies to composite allows absolute adaptation of the restoration to the true
resins as well, bonding to the cavity margin. The Achilles dentin surface, essential in the case of resins and impor-
heel of composite is its failure to bond to cementum. tant in the case of amalgams. Microleakage is increased
A well-done study at the Medical College of Georgia if the smear layer remains, whereas dentin permeability
compared for leakage Class V restorations placed entire- is increased if the smear layer is removed. Jodaikin and
ly within root surfaces. The specimens were thermocy- Austin recommended the removal of the smear layer
cled in dye, thousands of times, between 5C and under amalgams as early as 1981.290
55C.292 Although leakage into the cementum margins How can one have it both ways: improved filling adap-
was noted in all specimens, microleakage through to the tation yet guaranteed pulp health? The answer seems to
dentin was worse around amalgams and glass ionomer lie in agents that clean the dentin surface yet leave the
cements. Surprisingly, the least leakage occurred around tubules still plugged or, better yet, completely clean the
a light-cured composite resin (Aurafill, Johnson & dentin and the tubuli orifices and then replug the
Johnson; New Brunswick, N.J.) placed without a tubules with a precipitate or a bonding agent.
dentin-bonding agent.292 Duke and colleagues at Indiana stated that polyacrylic
Smear Layer. Inside the cavity, the smear layer is acid gave the best result in removing the smear layer.293
good news and bad news or damned if you do or The Laboratory of the Government Chemist,
damned if you dont. If the smear layer remains, it pro- Department of Industry in England (where glass
ionomer cements were developed) recommended the
use of surface conditioners of high molecular
weight.294 They achieved their highest bond strengths
with either polyacrylic acid, tannic acid (tanning agent
for collagen), or a surface active microbicidal solution
from Sweden, Tublicid (AB Bofors Nobelknut,
Sweden), which contains EDTA, chlorhexidine glu-
conate, and a wetting agent. All are biocompatible.
Citric acid, EDTA, and ferric chloride, were found to be
much less effective.
Pashley and the English researchers227,291 agree that
if the tubules are opened, they must be reoccluded.
This is accomplished by the new oxalates or, in the case
of amalgam placement, castings, or jacket cementation,
by one of the new liners such as Barrier or one of the
new dentin adhesives such as 4-META.
Washout. If type 1 (luting agent) glass ionomer
cements or type 2 (restorative material) ionomers are
used, it is imperative that these cements do not wash
out, particularly when the gingival wall of the restora-
tion is placed below the cementoenamel junction.295
The Product Evaluation Laboratory of the University of
California, San Francisco, thermocycled a number of
these restorations with either polymer-type bonding
agents or glass ionomer cements beneath composite
fillings.295 They were particularly careful to avoid
hydration or dehydration of the glass ionomers. Dye
penetration studies after severe thermocycling proved
Gingivaseal (Parkell Co.; Farmingdale, N.Y.) to be the
Figure 4-50 Longitudinal section of dentinal tubule containing a most effective glass ionomer as far as insolubility was
smear plug (S.P.) emerging from the smear layer (SL). Reproduced concerned. The least soluble polymer liner was
with permission from Pashley DH.233 Urename (Cadeo, USA).
rials becoming a part of the tooth, not merely sitting months later, if there has been no discomfort, pulp
in the tooth as an amalgam or an inlay will do. vitality should be determined, and, if vital, the provi-
If all of these protective measures are takenin lin- sional filling and the ZOE base are removed and the
ing, basing, and incremental fillingthere should be softened dentin carefully excavated. Fusayama pointed
no cause for pulpal sensitivity or death. out that carious softened dentin has two layers: a top
Bertolotti also addressed the sensitivity problems part of dead tissue and a softened bottom layer that is
that develop following crown or inlay cementation.301 still alive and capable of remineralization. By repeated
He pointed out that nearly all cases are in molars and applications of a red stain (Caries Detector, Kuraray,
that it seemingly makes no difference what the luting Japan), the dead tissue dentin is stained and carefully
agent might beresin cements, zinc phosphate, glass removed, leaving the living dentin to be capped.304
ionomerthe results are the same. Sensitivity dissi- (8) If acceptable, dentin is found covering the pulp, and
pates in about 6 months. a new base of calcium hydroxide is inserted in the cav-
Caries Control. By not exposing the pulp, the den- itys deepest points. This base and the dentin walls
tist can avoid inflicting iatral injury. Even in the face of should then be coated with a dentin bonding agent to
deep caries, the dentin cover should be maintained if prevent future microleakage. The bonding agent
bacteria have not penetrated through to the pulp. should then be covered by a thick cement base and a
Fauchard, in 1746, probably said it best: exposing permanent restoration is placed. (9) On the other
the nerve and making the cure worse than the dis- hand, if the pulp tests nonvital, if chronic pulpitis is
ease.302 Sir John Tomes, in 1859, voiced a similar con- suspected, or if an exposure is encountered, either from
cern: [it is] better to allow some carious dentin to instruments or caries persisting under the base, appro-
remain over the pulp rather than run the risk of sacri- priate endodontic treatment is performed based on the
ficing the tooth. state of development of the pulp and the closure of the
The modern version of these warnings by Fauchard apical foramen.
and Tomes has developed a technique of caries control, It would seem that the success of indirect pulp cap-
often mistermed indirect pulp capping, which means ping is dependent on the health of the pulp (ie, has it
leaving carious dentin permanently under the filling. already become infected and hence inflamed?). How
In the modern version, however, carious dentin is not thick is the remaining dentin, and is it infected or is it
purposely left under a permanent restoration but is capable of remineralization? How effective is the calci-
left there only temporarily as the pulp is allowed to um hydroxide dressing? Calcium hydroxide is the only
recover and protect itself with a layer of irritation factor that can be immediately controlled.
dentin. To a great extent, the success of this procedure In this case, calcium hydroxide is not being used as
will depend on the genus of bacteria in the remaining a liner to protect the pulp but rather as an antibacter-
dentin. If they are facultative anaerobes, continued ial agent and mild pulp stimulant to produce irrita-
breakdown may be the end result. On the other hand, tion dentin.
if healing progresses, irritation dentin may be pro- To accomplish these two objectives, nonsetting cal-
duced in amounts that may fill an entire pulp horn; cium hydroxide paste in water, saline, or methylcellu-
remember, however, that irritation dentin is still pene- lose best serves the purpose. In this form, the pH is at
trable by microorganisms and medicaments.303 least 11, which is an antibacterial alkalinity. If a minute
The technique is carried out in the following man- pulp exposure has been overlooked, it will serve as a
ner: (1) the rubber dam is applied, and (2) the soft car- pulp capping and stimulate an increase in mineraliza-
ious dentin is removed along the walls of the cavity and tion within the dentin.305
as far pulpally as possible without exerting pressure on In this nonpermanent situation, British researchers
the pulp roof. (For this, Caridex might be used.) (3) found calcium hydroxide paste in saline to be much
The cavity is washed with lukewarm water and is then more effective than a commercial hard-setting calcium
carefully dried without desiccation. (4) A layer of calci- hydroxide cement (LIFE, Kerr Dental; Orange, Calif.).
um hydroxide is applied over the entire dentin surface. This group had significantly larger volumes of
(5) A thick mix of ZOE cement (chemically pure) is inflamed pulp tissue than theCH paste group. Not
then applied without pressure over the pulp floor. (The unexpectedly, there were also significantly more cases
ZOE should be prepared by incorporating as much zinc (16 versus 7) with bacteria under the hard-setting ver-
oxide into the mix as possible and then removing sus the soft calcium hydroxide.305
excess eugenol with a squeeze cloth.) (6) A good pro- In an extensive review of calcium hydroxide, anoth-
tective provisional filling is then placed. (7) Three to six er British group pointed out that as a pulp dressing,
calcium hydroxide stimulates healing due to the anti- In spite of these circumstances, studies have indicat-
bacterial activity rather than its mineralization ed that an injured pulp has some capacity to recover,
effect.306 They made the important point, however, but the degree is uncertain. However, what is important
that the material has no beneficial effect on the heal- to the clinician is whether the tooth requires endodon-
ing of an inflamed pulp, and its use would appear to be tic treatment or is amenable to pulp maintenance or
indicated for the treatment of healthy or superficially preventive therapy.
contaminated pulps where bacteria have not penetrat- Pulpal pathosis is basically a reaction to bacteria and
ed into the deeper part.306 bacterial products. This can be a direct response to
High success rates for indirect pulp capping are caries, microleakage of bacteria around fillings and
frequently reported but are based on clinical experi- crowns, or bacterial contamination after trauma, either
mentation. The success criteria used are a lack of radi- physical or iatrogenic. The pulp responds to these chal-
ographically observable periradicular lesions and lack lenges by the inflammatory process. Histologic changes
of pain. Periradicular radiolucency, however, takes associated with inflammation may occur even with a
longer to develop than the usual length of these studies, relatively mild stimulus to the tooth. The vibration of a
and lack of pain in the presence of inflammation is the bur across enamel or the early penetration of caries
rule rather than the exception. Thus, histopathologic through the dentinoenamel junction may induce visi-
and microbiologic studies that show continued, ble, but slight, inflammation in the underlying pulp.312
although often slow, breakdown of the pulp under The pulp reaction to caries is basically progressive. As
remaining caries should be accepted as a reflection of the depth of caries increases, the degree of injury
the actual clinical condition. Many of these teeth even- increases. Significantly, the inflammation and accom-
tually need endodontic treatment. panying hard tissue reaction tend to localize at the base
of the involved dentinal tubules that provide the pri-
Summary mary passageway (Figures 4-52, 4-53, and 4-54).
From this discussion, one can readily see that a number However, the pulp may withstand a very deep but non-
of measures and programs may be undertaken by the penetrating carious lesion (Figure 4-55).
dentist and staff to prevent discomfort and sensitivity
as well as insult and injury to the dental pulp. Most of HARD TISSUE RESPONSE TO IRRITATION
all, one must follow the Hippocratic Oath and not
Irritation Dentin
inflict through ones ministrations additional trauma
or irritation on the patient (the pulp). The undisturbed odontoblast synthesizes and secretes
dentin matrix and then induces it to mineralize. The
PULPAL PATHOLOGY formed dentin demonstrates predictable morphology
Many clinicians believe that the pulpal response to and function with only slight variations. Before erup-
injury, treatment, and trauma is unpredictable. As a tion and contact with the opposing tooth, the dentin
result, dentists have been unable to correlate clinical formed is termed primary. After occlusal contact, the
signs and symptoms with a corresponding specific his- dentin is termed secondary. Although there are con-
tologic picture.307311 flicting terminologies, some authors contend that there
The pulp is basically connective tissue, as found else- is a visible alteration in the dentin that differentiates
where in the body. However, several factors make it secondary from primary dentin.313 However, primary
unique and thus alter its ability to respond to irritation: and secondary dentin are usually indistinguishable and
possess similar properties. The term secondary is
1. The pulp is almost totally surrounded by a hard tis- used for the continuous, slow formation of primary
sue (dentin), which limits the area for expansion and dentin after eruption.314
restricts the pulps ability to tolerate edema. An odontoblast that is mildly stimulated may form
2. The pulp has almost a total lack of collateral circula- dentin that closely resembles normal physiologic
tion, which severely limits its ability to cope with dentin. However, since odontoblasts are incapable of
bacteria, necrotic tissue, and inflammation. mitosis,315 they must be replaced by underlying cells
3. The pulp possesses a unique cell, the odontoblast, that mature from dividing undifferentiated precursors
as well as cells that can differentiate into hard tis- or by redifferentiation of fibroblasts316 (Figure 4-56).
suesecreting cells that form more dentin and/or These new cells are atypical, frequently without a
irritation dentin in an attempt to protect the pulp process, and thus form an atypical irregular structure
from injury. called irritation or reparative dentin317 (Figure 4-57).
The term irritation dentin more appropriately Figure 4-53 A, Intermediate magnification of the coronal area of
describes the dentins genesis than reparative.318 The the tooth from Figure 4-52. Note the amount of irritation dentin on
term irritation is based on clinical, anatomic, and his- the left (affected) side of the pulp relative to the right (unaffected)
side. The pulp vessels are very dilated. Hematoxylin and eosin stain.
tologic findings. To designate this as reparative dentin B, Same specimen as shown in A, stained for bacteria. Note the
is misleading; its formation may falsely indicate that invasion of microorganisms deep into some (arrows) but not all
the pulp is healing or repairing.319 In fact, its formation tubules. Bacteria have not penetrated as deeply as the hematoxylin
occurs independently of the presence of inflammation and eosin stain (in A) suggests.
and may form on the walls of an irreversibly damaged
pulp.320 Continued irritation dentin formation may
depend on persistent injurious stimuli; such a condi-
tion is neither desirable nor reparative.321
An example of irritation dentin formation is the
reaction following impact trauma and subluxation in
which the blood supply is temporarily disrupted. It can
be speculated that the marked changes following such
an injury result from odontoblast replacement. As a
result of the vascular impairment, the odontoblasts
degenerate in large numbers. New cells arise, align
themselves along exposed predentin, and rapidly form
a very irregular hard tissue. The delineation between
the old and new altered hard tissue is called the calcio-
traumatic line322 (Figure 4-58). Frequently, there are
inclusions of tissue or bacteria in this region that
become entrapped in or under the forming irritation Figure 4-54 High magnification of irritation dentin formed
under the carious lesion seen in Figure 4-52 and 4-53. Irritation
dentin. Newly differentiated cells apparently do not
dentin (center) is clearly less tubular than the original dentin seen
possess the inhibitory regulation of normal odonto- on the left side of the micrograph. Note the lack of a well-defined
blasts. Thus, these new cells are uncontrolled and con- odontoblastic layer and the irregular shape of cells at the pulp mar-
tinue to form irritation dentin until there is almost gin of the dentin.
Figure 4-60 A, Indirect pulp cap. Although extensive irritation dentin has formed under carious lesion, it has not protected the pulp from
effects of irritants, as shown by microabscess (a). Frequently, the barrier is incomplete, as evidenced by the opening (arrow), forming com-
munication between carious dentin and the underlying pulp. B, Area of box in A. Silver nitrate was placed on the surface of caries and can
be seen passing through tubules in a pulpward direction. It readily crosses the calciotraumatic line, into underlying irritation dentin and
eventually into pulp. Reproduced with permission from Langeland K. JOE 1982;7:148.
underlying pulp and believe its formation is depend- ly unknown and remains the subject of much specula-
ent on the presence of irritation. They have demon- tion and considerable misinformation.
strated its permeability, permitting passage of chemi-
cals and bacteria and other substances332 (Figure 4- PULPITIS
60). The exact degree of permeability remains to be The nature of the inflammatory response is related to
demonstrated experimentally. Certainly, the presence both direct and immune mechanisms. Direct injury of
of irritation dentin delays, but does not prevent, the the pulp from caries occurs via the dentinal tubules
eventual penetration of caries into the pulp. (Figure 4-61). Irritants (bacterial by-products, disinte-
Unfortunately for the pulp, formation of irritation grating elements of carious dentin, or chemicals from
dentin and its morphology under caries do not occur foods) either permeate through tubules (Figure 4-62)
predictably. Fingers of soft tissue may extend from the to contact and destroy odontoblasts and underlying
underlying pulp to penetrate deep into the hard tissue cells or have an osmotic effect that also destroys cells by
(see Figure 4-60). The barrier may therefore be incom- rapid, forceful fluid movement.334
plete and relatively nonprotective.321,333 Its impor- The immune process and accompanying injury com-
tance relative to maintenance of pulpal health is large- prise another mechanism responsible for the develop-
A B
C
Figure 4-63 A, Section of noncarious adult molar. Note absence of any pulp changes under normal dentin. B, Section of carious adult
molar. Carious process has invaded dentin. Note dilated vessels concentrated in a region of pulp under affected tubule. C, High magnifica-
tion of inflammatory lesion in coronal pulp seen in B. D, Higher magnification of a portion of an inflammatory lesion. L = lymphatic ves-
sel; V = venule filled with red blood cells. Reproduced with permission from Bernick S. JDR 1977;56:841.
ment of pulpitis.335 Immunocompetent cells, immuno- nearest the site of injury and extravasation of fluid into
globulins (antibodies), and complement factors have the connective tissue spaces (edema) cause an elevation
been identified in inflamed pulpal tissues. Both the in local pressure. This edema alters or destroys the
humoral and cellular responses occur in the pulp.336 odontoblast layer. Chemical modification of the
The end result, whether induced by direct irritation ground substance also occurs, as evidenced by an
or from the immune system, is the release of chemical increased eosinophilia.337 Marked dilation of vessels
mediators that initiate inflammation. This is a vascular (Figure 4-63) leads to slowing of erythrocytes and the
response. The increase in the permeability of vessels margination of leukocytes along the walls (Figures 4-64
B C
Figure 4-66 A, Micrograph of pulp and carious dentin in an adult molar. Dark areas in the right portion of dentin are microorganisms in
dentinal tubules. The calciotraumatic line (arrow) divides dentin into original primary dentin and subsequent irritation dentin. The tubu-
lar pattern of irritation dentin is irregular, and the underlying pulp is infiltrated with chronic inflammatory cells. B, Transmission electron
micrograph of pulp affected by dentinal caries showing chronic inflammatory cells. C, Transmission electron micrograph of carious dentin.
Invasion of dentinal tubules with cocci-like microorganisms. Reproduced with permission from Torneck C. In: Roth G, Calmes R, editors.
Oral biology. Toronto: CV Mosby; 1981. p. 138.
B C
Figure 4-68 A, Micrograph of carious exposure in an adult molar. Microorganisms have penetrated the full thickness of primary and irri-
tation dentin. Small focal microabscess is present in pulp tissue subjacent to exposure. Peripheral portion of the microabscess displays
numerous polymorphonuclear leukocytes, and the surrounding pulp displays infiltration with polymorphonuclear leukocytes and mononu-
clear cells. B, Transmission electron micrograph of gram-positive coccus (arrow) within phagosome of macrophage in human pulp exposed
to dental caries. C, Transmission electron micrograph of polymorphonuclear response in pulp subjacent to carious exposure. Reproduced
with permission from Torneck C. J Oral Pathol 1977;6:82.
Microscopically, the pulp polyp is a complex of new Before the lesion has grown to any extent, its surface
capillaries, proliferating fibroblasts, and inflammatory layer consists of massed necrotic cells and leukocytes with
cells. Support for the protruding mass is supplied by chronic inflammatory cells beneath forming a zone of
collagenous fibers rooted in the deeper pulp tissue of variable width. As the tissue expands, it may acquire a
the chamber. Sensory nerve elements are almost totally stratified squamous epithelial cover that may form by a
absent near the surface, in contrast to the rich innerva- true cell graft. Cells of the oral mucosa floating free in the
tion and exquisite sensitivity of an exposed pulp that is saliva may grow over the surface of the highly vascular-
not hyperplastic. ized young connective tissue, or a direct migration of
Figure 4-69 Adult molar with deep caries. The entire coronal pulp Figure 4-71 Ulceration of entire surface of human pulp in
demonstrates chronic inflammation with several encapsulated response to carious exposure. Beneath the necrotic surface of ulcer
microabscesses. Irritation dentin was probably produced before is a zone of dense leukocytic infiltration. Below this is a zone of pro-
pulp developed microabscesses. Reproduced with permission from liferating fibroblast cells and collagenous fibers, that is, a collage-
Matsumiya S et al.350 nous or fibrous zone. Irregular calcifying masses (arrow) are some-
times found in this area. Toward the floor of the pulp chamber, the
connective tissue is relatively normal. Reproduced with permission
from Matsumiya S et al.350
epithelial cells may occur from the gingiva.350 dentin, there is insufficient drainage of inflammatory
Hyperplastic pulpitis is irreversible and therefore requires fluids. This results in localized increases in tissue pres-
pulpectomy and root canal treatment or extraction. sures, causing the destruction to progress unchecked
until the entire pulp is necrotic (Figure 4-75). The rate
Necrosis of progress of liquefaction necrosis varies. The speed
As inflammation progresses, tissue continues to disin- may correlate with the ability of the tissue to drain or
tegrate in the center to form an increasing region of liq- absorb fluids, thus minimizing increases in intrapulpal
uefaction necrosis (Figure 4-74). Because of the lack of pressure. To demonstrate the importance of a closed
collateral circulation and the unyielding walls of the lesion, experiments were performed in which pulps in
C D
Figure 4-75 A, Pulp necrosis. The pulp of a maxillary premolar has undergone necrosis, although an area of vitality persists near the
apex in one canal (arrow). Note the periradicular abscess, although the radiograph of this tooth (lower left) demonstrates no periradic-
ular bony changes. B, Region indicated by box in A. Pulp horn contains amorphous debris and concentration of bacteria. C, Region indi-
cated by box in B. Arrow indicates the so-called calciotraumatic line separating regular tubular dentin from irregular, less tubular, irri-
tation dentin. D, Histologic section adjacent to C, stained for bacteria. Bacteria, streaming down tubules (small arrow), are concentrat-
ed in the calciotraumatic line (large arrow). Bacteria are less numerous in underlying irritation dentin.
Figure 4-76 Bacterial penetration into tubules (left). Their source Figure 4-77 Narrow zone of response adjacent to region of lique-
is masses of bacteria in the canal space (right). faction necrosis. Collagen is arranged peripherally (arrow) around
the abscess, separating this irritant from underlying vital pulp tis-
sue. Inflammatory response in this tissue is surprisingly mild, with
few scattered cells.
Figure 4-78 A vital coronal pulp and associated periradicular Figure 4-79 Differing pulp responses to trauma. Both incisors
resorptive lesions (arrows), most likely to occur in young persons, suffered impact as well as caries and restorative trauma. It is not
as demonstrated by a newly erupted, but cariously involved, second clear why one pulp may react with extensive internal resorption and
molar in a 15-year-old patient. Usually, a periradicular lesion is why another pulp may form calcifications. Treatment was success-
associated with necrotic pulp, as is the case on the first molar. ful in the central incisor but unsuccessful in the lateral incisor; the
cork-in-a-sewer retrofilling failed.
A B
A C
Figure 4-84 A, Radiograph of canine intruded by trauma. B, Effect of hypoxia on pulp owing to intrusion. Myelinated nerve showing vac-
uolization of axon (closed arrow), disruption and smudging of myelin sheath (open arrow), and loss of cellular detail. C, Loss of cellular
detail in the nucleus (N) and cytoplasm (C). Note cell clumping in nucleus and loss of organelles with rupture of lysosome (arrow) in cyto-
plasm. (Courtesy of Dr. James Simon.)
As cell necrosis (both coagulation and liquefaction Since the blood supply to the pulp is compromised
necrosis) progresses, histologic changes occur in the and possibly absent, the removal of the necrotic pulp
nucleus and the cytoplasm.372374 The nucleus under- by phagocytic cells is difficult if not impossible. That
goes karyolysis, pyknosis, and karyorrhexis. Karyolysis leaves two possible sequelae: dystrophic calcification at
is progressive fading of the nucleus. Pyknosis describes the apical openings entombing the necrotic pulp indef-
gradual shrinkage, and karyorrhexis is nuclear frag- initely or invasion by bacteria, resulting in a gan-
mentation, the end result being disappearance of the grenous necrosis. This term is an old one, but it
nucleus. The process is much slower in coagulation describes the result of bacterial invasion of tissue that
than in liquefaction necrosis. died secondary to hypoxia a similar situation to that
The cytoplasm of the cell undergoing necrosis shows seen in gangrene of an extremity such as a leg from
signs of clumping owing to denaturation of cytoplas- coagulation necrosis owing to impaired circulation fol-
mic proteins. The histologic appearance is one of an lowed by bacterial ingrowth into the dead tissue.
acidophilic, granular, opaque mass. As the necrotic Dystrophic calcification may occur at the apical
process continues, the pulp tissue gradually loses its canal openings, where coagulation necrosis attracts cal-
recognized morphology and ends up as a diffuse tissue cium salts from the surrounding environment. This is
mass containing the outline of cells and remnants of similar to calcification subjacent to layers of coagula-
fibers, vessel walls, and nerves.371 tion necrosis produced by caustic pulp-capping agents.
A B
Figure 4-85 A, Pulp 2 weeks after trauma. Note
pyknotic nuclei, loss of cellular detail, and absence of
inflammation. The tissue is necrotic. B, Pulp 4 weeks
after trauma. Almost no cells are visible, and inflamma-
tion is absent. Red blood cells trapped in vessels are dete-
riorating. C, Pulp 2 years after trauma. No cells are visi-
bleonly dystrophic calcification and a collagen skele-
ton. (Courtesy of Dr. James Simon.)
Gangrenous necrosis of the pulp results from bacte- Once bacteria have invaded the necrotic pulp, they
ria entering the pulp space containing coagulation release enzymes to break down the necrotic tissue for
necrotic tissue. Bacterial invasion cannot occur by ana- assimilation of the available nutrients; by the process of
choresis because the blood circulation to the pulp is heterolysis, liquefaction (also called wet gangrene)
now nonexistent; it must occur through the open apex occurs. This activity produces an abundance of
or through pathways in the hard tissues of the tooth. by-products, which eventually leak into periradicular
Also, tooth infractions, where cracks extend from the tissues, causing inflammatory and immunologic reac-
enamel or cementum through dentin, would be anoth- tions. These are commonly referred to as acute exacer-
er possible pathway. Another may be lateral canals, bations with pain and swelling: a periradicular abscess.
either already exposed to the oral environment by peri- If the egress is slow, the reaction may be more gradual
odontal disease or subsequently opened by scaling pro- and chronic, resulting in an abscess that drains through
cedures. It is also possible that bacteria may enter a fistulous tract.
through exposed dentinal tubules. With the tubules The events involved in pulpal infarcts owing to
either empty or containing necrotic odontoblastic hypoxia have been described. The clinical implication
processes, bacteria can grow in a pulpal direction and is that coagulation necrosis may go undetected for var-
toward a ready food source. ious lengths of time, but when bacteria gain access to
A B
Figure 4-86 A, Discolored left central and lateral incisors. The patient reported accidental trauma 20 years earlier. B, Pulp tissue from the later-
al incisor appeared fibrotic. Histologic picture shows uniformly amorphous tissue with dystrophic calcification. (Courtesy of Dr. James Simon.)
this necrotic pulp, the potential for a flare-up is strong. 11. Trowbridge HO. Pathogenesis of pulpitis resulting from dental
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Chapter 5
PERIRADICULAR LESIONS
Mahmoud Torabinejad and Richard E. Walton
Other investigators examined the flora of previously macrophages, and lymphocytes,7 all of which have spe-
traumatized teeth with necrotic pulps with and with- cific roles in inflammatory responses.
out periradicular pathosis.3,4 Teeth without apical
lesions were aseptic, whereas those with periradicular Mediators of Periradicular Lesions
lesions had positive bacterial cultures. Korzen et al. The inflammatory process is not completely under-
demonstrated the importance of the amount of micro- stood, but a number of substances have been implicat-
bial inoculum in the pathogenesis of pulpal and peri- ed as mediators of inflammation. They include neu-
radicular lesions.5 They showed that higher levels of ropeptides, fibrinolytic peptides, kinins, complement
contamination lead to greater inflammatory responses. fragments, arachidonic acid metabolites, vasoactive
In addition to bacterial irritation, the periradicular amines, lysosomal enzymes, cytokines, and mediators
tissues can be mechanically irritated and inflamed. of immune reactions.
Physical irritation of periradicular tissues can also Neuropeptides. These are proteins generated from
occur during root canal therapy if the canals are instru- somatosensory and autonomic nerve fibers following
mented or filled beyond their anatomic boundaries. tissue injury. They include substance P (SP), calcitonin
Periradicular tissues can be irritated by impact trauma, generelated peptide (CGRP), dopamine hydrolase,
hyperocclusion, endodontic procedures and accidents, neuropeptide Y originating from sympathetic nerve
pulp extirpation, overinstrumentation, root perfora- fibers, and vasoactive intestinal polypeptides generated
tion, and overextension of filling materials. from parasympathetic nerve fibers.8
Chemicals are used as adjuncts for better dbride- Substance P is a neuropeptide present in both the
ment and disinfection of the root canal system. An in peripheral and central nervous systems. The release of
vitro study, however, has shown that many of these SP can cause vasodilation, increased vascular perme-
chemicals are highly concentrated and not biocompat- ability, and increased blood flow during inflammation.
ible.6 Irrigating solutions such as sodium hypochlorite In addition, it can cause the release of histamine from
and hydrogen peroxide, intracanal medications, and mast cells and potentiate inflammatory responses.
chelating agents such as ethylenediaminetetraacetic Calcitonin generelated peptide has been localized
acid (EDTA) can also cause tissue injury and inflam- in small to medium sensory nerve fibers. Like SP, it is a
mation if inadvertently extruded into the periradicular potent vasodilator and may play a role in the regulation
tissues. Some components in obturation materials can of blood flow in bone, periosteum, and other sites.
irritate the periradicular tissues when extruded beyond Substance P and CGRP have been found in pulp and
the root canal system. periradicular tissues.9
Fibrinolytic Peptides. The fibrinolytic cascade is
Periradicular Reaction to Irritation triggered by the Hageman factor, which causes activa-
The periradicular tissues consist of apical root cemen- tion of circulating plasminogen, previously known as
tum, periodontal ligament, and alveolar bone. The apical fibrinolysin and digestion of blood clots. This results in
periodontium is also richly endowed with cellular and release of fibrinopeptides and fibrin degradation prod-
extracellular components containing blood and lymphat- ucts that cause increased vascular permeability and
ics, as well as sensory and motor nerve fibers supplying leukocyte chemotaxis.10
both pulp and periodontium. Other structural elements Kinins. Release of kinins causes many signs of
of the periodontal ligament include ground substance, inflammation.11 They include chemotaxis of inflam-
various fibers, fibroblasts, cementoblasts, osteoblasts, matory cells, contraction of smooth muscles, dilation
osteoclasts, histiocytes, undifferentiated mesenchymal of peripheral arterioles, increased vascular permeabili-
cells, and the epithelial cell rests of Malassez. ty, and pain. The kinins are produced by proteolytic
Irritation of periradicular tissues results in inflam- cleavage of kininogen by trypsin-like serine proteases,
matory changes taking place. The vascular response to the kallikreins. The kinins are subsequently inactivated
an injury includes vasodilation, vascular stasis, and by removal of the last one or two C-terminal amino
increased vascular permeability. The latter leads to acids by the action of peptidase.12 The kallikreins are
extravasation of fluid and soluble components into the also able to react with other systems, such as the com-
surrounding tissues. These vascular changes cause red- plement and coagulation systems, to generate other
ness, heat, swelling, and pain, which are the cardinal trypsin-like serine proteases.13 Elevated levels of kinins
signs of inflammation. The inflammatory cells involved have been detected in human periapical lesions.14
in various stages of tissue injury and repair include Complement System. The complement system con-
platelets, PMNs, mast cells, basophils, eosinophils, sists of a number of distinct plasma proteins capable of
interacting with each other and with other systems to leukocytes and mast cells are the major sources for pro-
produce a variety of effects.15 Complement is able to duction of LTs.21 Leukotriene B4 is a powerful chemo-
cause cell lysis if activated on the cell membrane and tactic agent from PMNs. Increased levels of LTB4 have
also to enhance phagocytosis through interaction with been found in symptomatic human periapical
complement receptors on the surface of phagocytic lesions.22 Other leukotrienes such as LTC4, LTD4, and
cells. Complement can also increase vascular perme- LTE4 are chemotactic for eosinophil and macrophage,
ability and act as a chemotactic factor for granulocytes cause increased vascular permeability, and stimulate
and macrophages. The complement system is a com- lysozyme release from PMNs and macrophages.15
plex cascade that has two separate activation pathways Vasoactive Amines. Vasoactive amines are present
that converge to a single protein (C3) and complete the in mast cells, basophils, and platelets. Histamine, the
cascade in a final, common sequence. Complement can major one of these substances, is found in all three cell
be activated through the classic pathway by antigen- types, whereas serotonin is present only in platelets.21
antibody complexes or through the alternative pathway Release of these materials causes increased vascular
by directly interacting with complex carbohydrates on permeability, as well as muscle contraction of airways
bacterial and fungal cell walls or with substances such and gastrointestinal tracts. Numerous mast cells have
as plasmin. been detected in human periradicular lesions.23,24
Several investigators have found C3 complement Physical or chemical irritation of periradicular tissues
components in human periradicular lesions.10 during root canal therapy can cause mast cell de-
Activators of the classic and alternative pathways of the granulation. The discharged vasoactive amines can ini-
complement system include immunoglobulin (Ig) M, tiate an inflammatory response or aggravate an existing
IgG, bacteria and their by-products, lysosomal enzymes inflammatory process in the periradicular tissues.
from PMNs, and clotting factors. Most of these activa- Lysosomal Enzymes. Lysosomal enzymes are stored
tors are present in periradicular lesions. Activation of
preformed in membrane-bound bodies within inflam-
the complement system in these lesions can contribute
matory cell cytoplasm. Lysosomal bodies are found in
to bone resorption either by destruction of already
PMNs, macrophages, and platelets and contain acid as
existing bone or by inhibition of new bone formation
well as alkaline phosphatases, lysozyme, peroxidase,
via the production of prostaglandins (PGs).
cathepsins, and collagenase. They can be released via
Arachidonic Acid Metabolites. Arachidonic acid is
exocytotic type events during cell lysis or secreted dur-
formed from membrane phospholipid as a result of cell
ing phagocytosis. Release of these enzymes into the tis-
membrane injury and phospholipase A2 activity and is
further metabolized. sues causes increased vascular permeability, leukocyte
Prostaglandins are produced as a result of the acti- chemotaxis, generation of C5a from C5, and
vation of the cyclooxygenase pathway of the arachi- bradykinin formation.15 Aqrabawi and associates
donic acid metabolism. Their pathologic functions examined human periradicular lesions for the presence
include increased vascular permeability and pain. of lysosomal hydrolytic arylsulfatase A and B and
Torabinejad and associates demonstrated in an animal found higher levels of these substances in lesions of
model that periradicular bone resorption could be endodontic origin compared to the control tissues.25
inhibited by administration of indomethacin Cytokines. The major cytokines that have been
(Indocin), an antagonist of PGs.16 High levels of PGE2 implicated in bone resorption are various interleukins
were found in periradicular lesions of patients with (ILs) and tumor necrosis factors (TNFs).15
symptomatic apical periodontitis (SAP).17 Takayama Interleukin-1 is produced primarily by monocytes
et al.18 and Shimauchi and coworkers19 confirmed and macrophages.26,27 Human monocytes produce at
these findings by demonstrating lower levels of PGE2 least two IL-1 species, IL-1 and IL-1.28 Interleukin-
associated with asymptomatic large lesions or cessation 1 is the major form secreted by human monocytes.
of symptoms subsequent to emergency cleaning and The chief component of osteoclast activating factor was
shaping of root canals. Miyauchi et al. used immuno- purified and found to be identical to IL-1.29
histochemical staining and found PGE2, PGF2, and Interleukin-1 is the most active of the cytokines in
6-keto-PGF1 in the experimentally induced periapi- stimulating bone resorption in vitro, 15-fold more
cal lesions in rats.20 potent than IL-1 and 1,000-fold more potent than
Leukotrienes (LTs) are produced as a result of the TNFs.30 Interleukin-1 has been associated with
activation of the lipoxygenase pathway of the arachi- increased bone resorption in vivo in several diseases.
donic acid metabolism. Polymorphonuclear neutrophil Interleukin-1 has been implicated in the bone resorp-
tion for periodontal disease and periradicular gens such as bacteria or their by-products interact with
lesions.3139 either IgG or IgM antibodies. The complexes can bind
Interleukin-6 is produced by a number of cells with to the platelets and cause release of vasoactive amines,
a wide range of cell targets.40 It is produced by increased vascular permeability, and chemotaxis of
osteoblasts, but in response to other bone resorptive PMNs. The pathologic effects of immune complexes in
agents such as parathyroid hormone, IL-1, and 1,25- periradicular tissues have been demonstrated in experi-
hydroxyvitamin D3.41 Interleukin-6 is produced dur- mental animals. Torabinejad and associates placed sim-
ing immune responses and may play a role in human ulated immune complexes in feline root canals and
resorptive diseases such as adult periodontitis42 and showed a rapid formation of periradicular lesions and
rheumatoid arthritis.43 Recent studies have shown that accumulation of numerous PMNs and osteoclasts.16
IL-6 may play a significant role in the pathogenesis of These findings were confirmed when Torabinejad and
human periradicular lesion.44,45 Kiger immunized cats with subcutaneous injections of
Tumor necrosis factor- and TNF- have bone keyhole-limpet hemocyanin and challenged the animals
resorption activities similar to that of IL-1. Their effects with the same antigen via the root canals.50
on osteoclasts are indirect and are mediated through Radiographic and histologic observations showed the
osteoblasts.46 The effect of TNF- on bone resorption development of periradicular lesions consistent with
is dependent on PG synthesis.47 Tumor necrosis factors characteristics of an Arthus-type reaction.
have been detected in periradicular lesions of experi- Immune complexes in human periradicular lesions
mental animals and humans.38,39,48,49 have been found using the anticomplement immuno-
Immunologic Reactions. In addition to the non- fluorescence technique, localized immune complexes
specific mediators of inflammatory reactions, im- in human periradicular specimens.51 Torabinejad and
munologic reactions also participate in the formation associates measured the serum concentrations of circu-
and perpetuation of periradicular pathosis.10,15,35 lating immune complexes in patients with asympto-
These reactions can be divided into antibody- and cell- matic and symptomatic periradicular lesions. The
mediated responses. The major antibody-mediated results indicated that immune complexes formed in
reactions include IgE mediated reactions and antigen- chronic periradicular lesions are confined within the
antibody (immune complex)mediated reactions. lesions and do not enter into the systemic circulation.
Immunoglobulin Emediated reactions occur as a However, when the serum concentrations of circulating
result of an interaction between antigens (allergens) immune complexes in patients with acute abscesses
and basophils in the blood or mast cells in the tissues. were compared with those of people without these
Vasoactive amines such as histamine or serotonin are lesions, they found that these complexes entered the
present in preformed granules in basophils and mast circulation in patients with symptomatic periradicular
cells and are released by a number of stimuli includ- abscesses. The concentrations of these complexes came
ing physical and chemical injuries, complement acti- back to normal levels after either root canal therapy or
vation products, activated T lymphocytes, and bridg- extraction of involved teeth.52,53
ing of membrane-bound IgE by allergens. Numerous Cell-Mediated Immune Reactions. Numerous B and
mast cells have been detected in human periradicular T lymphocytes have been found in human periradicular
lesions.23,24 IgE molecules have also been found in lesions by the indirect immunoperoxidase method,54
human periapical lesions.10 Presence of potential with the T cells outnumbering the B cells significantly.
antigens in the root canals, IgE immunoglobulin, and A number of investigators have found approximately
mast cells in pathologically involved pulp and peri- equal numbers of T-cell subsets in chronic lesions (T
radicular lesions indicate that IgE-mediated reactions helper/T suppressor ratio < 1.0).5558 Stashenko and Yu
can occur in periradicular tissues. Irritation of demonstrated in developing lesions in rats that T helper
periradicular tissues during cleaning, shaping, or cells outnumber T suppressor cells during the acute
obturation of the root canal system with antigenic phase of lesion expansion. In contrast, T suppressor
substances can cause mast cell degranulation. The dis- cells predominate at later time periods when lesions are
charged vasoactive amines can initiate an inflamma- stabilized.58 Based on these results, it appears that T
tory response or aggravate an existing inflammatory helper cells may participate in the initiation of peri-
process in the periradicular tissues.15 radicular lesions, whereas T suppressor cells prevent
Antigen-Antibody or Immune Complex Reactions. rapid expansion of these lesions.
Antigen-antibody or immune complex reactions in The specific role of T lymphocytes in the pathogen-
periradicular tissues can be formed when extrinsic anti- esis of periradicular lesions has been studied by several
investigators.39,59,60 Wallstrom and Torabinejad irritation of the periapical tissues can cause SAP.
exposed the pulps of mandibular molars of athymic Impact trauma can also cause SAP (see chapter 15).
and conventional rats and left them open to the oral Sensitivity to percussion is the principal clinical fea-
flora for 2, 4, or 8 weeks.59 Statistical analysis of the tis- ture of SAP. Pain is pathognomonic and varies from
sue reactions to this procedure showed no significant slight tenderness to excruciating pain on contact of
difference between periradicular tissue responses of the opposing teeth. Depending on the cause (pulpitis or
two species of animals. Waterman and associates com- necrosis), the involved tooth may or may not respond
pared periradicular lesion formation in immunosup- to vitality tests. Regardless of the causative agents, SAP
pressed rats with that in normal rats and found no sig- is associated with the exudation of plasma and emigra-
nificant histologic differences between the two tion of inflammatory cells from the blood vessels into
groups.60 Fouad studied the progression of pulp necro- the periradicular tissues. The release of mediators of
sis and the histomorphometric features of periapical inflammation causes breakdown of the periodontal lig-
lesions in mice with severe combined immunodeficien- ament and resorption of the alveolar bone. A minor
cies.39 He found no significant differences between the physical injury, such as penetrating the periradicular
reaction and progression of pulp and periapical tissues tissues with an endodontic file, may cause a transient
between these animals and those in normal mice. These inflammatory response. However, a major injury, caus-
findings suggest that the pathogenesis of periradicular ing extensive tissue destruction and cell death, can
lesions is a multifactorial phenomenon and is not total- result in massive inflammatory infiltration of the peri-
ly dependent on the presence of a specific group of cells radicular tissues. Although the dynamics of these
or mediators. inflammatory lesions are poorly understood, the con-
sequences depend on the type of irritant (bacterial or
CLINICAL CLASSIFICATION OF nonbacterial), degree of irritation, and host defensive
PERIRADICULAR LESIONS mechanisms. The release of chemical mediators of
Periradicular diseases of pulpal origin have been inflammation and their action on the nerve fibers in
named and classified in many different ways. These the periradicular tissues partially explain the presence
lesions do not occur as individual entities; there are of pain during SAP. Also, since there is little room for
clinical and histologic crossovers in the terminology expansion of the periodontal ligament, increased inter-
regarding periradicular lesions as the terminology is stitial tissue pressure can also cause physical pressure
based on clinical signs and symptoms as well as radi- on the nerve endings, causing an intense, throbbing,
ographic findings. In this chapter, periradicular lesions periradicular pain. Increased pressure may be more
are divided into three main clinical groups: sympto- important than the release of the inflammatory media-
matic (acute) apical periodontitis, asymptomatic tors in causing periradicular pain. The effect of fluid
(chronic) apical periodontitis, and apical abscess. pressure on pain is dramatically demonstrated on
Since there is no correlation between histologic find- opening into an unanesthetized tooth with this condi-
ings and clinical signs, symptoms, and duration of the tion. The release of even a small amount of fluid pro-
lesion,10,21 the terms acute and chronic, which are his- vides the patient with immediate and welcome relief.
tologic terms, will not be used in this chapter. Instead, Radiographs show little variation, ranging from nor-
the terms symptomatic and asymptomatic, which mal to a thickening of the periodontal ligament space
describe clinical conditions, will be used. (Figure 5-1) in teeth associated with SAP.
APICAL PERIODONTITIS Asymptomatic Apical Periodontitis
Depending on clinical and radiographic manifesta- Asymptomatic apical periodontitis (AAP) may be
tions, these lesions are classified as symptomatic or preceded by SAP or by an apical abscess. However,
asymptomatic periodontitis. the lesion frequently develops and enlarges without
any subjective signs and symptoms. Inadequate root
Symptomatic Apical Periodontitis canal treatment may also cause the development of
Symptomatic apical periodontitis (SAP) is a localized these lesions. Generally, a necrotic pulp gradually
inflammation of the periodontal ligament in the apical releases noxious agents with low-grade pathogenicity
region. The principal causes are irritants diffusing from or in low concentration that results in the develop-
an inflamed or necrotic pulp. Egress of irritants such as ment of AAP. This pathosis is a long-standing, smol-
bacteria, bacterial toxins, disinfecting medications, dering lesion and is usually accompanied by radi-
debris pushed into the periradicular tissues, or physical ographically visible periradicular bone resorption.
Figure 5-1 Radiographic features of symptomatic apical peri- Figure 5-2 Radiographic appearance of asymptomatic apical
odontitis. High amalgam restoration was placed on the occlusal periodontitis. Two distinct lesions are present at the periradicular
surface of a second mandibular molar. The periodontal ligament regions of a mandibular first molar with necrotic pulp.
space is widened at the apex (arrows). Clinically, the tooth is
extremely sensitive to percussion.
This condition is almost invariably a sequela to pulp apical bone, and sometimes the root cementum and
necrosis. dentin, is infiltrated by plasma cells, lymphocytes,
The clinical features of AAP are unremarkable. The mononuclear phagocytes, and occasional neutrophils.
patient usually reports no significant pain, and tests Occasionally, needle-like spaces (the remnants of cho-
reveal little or no pain on percussion. If AAP perforates lesterol crystals), foam cells, and multinucleated for-
the cortical plate of the bone, however, palpation of eign body giant cells are seen in these lesions (Figure
superimposed tissues may cause discomfort. The asso- 5-4).69 Animal studies have shown that cholesterol
ciated tooth has a necrotic pulp and therefore should crystals can cause failure of some lesions to resolve fol-
not respond to electrical or thermal stimuli. lowing nonsurgical root canal therapy.70 Nerve fibers
Radiographic findings are the diagnostic key.
Asymptomatic apical periodontitis is usually associat-
ed with periradicular radiolucent changes. These
changes range from thickening of the periodontal liga-
ment and resorption of the lamina dura to destruction
of apical bone resulting in a well-demarcated radiolu-
cency (Figure 5-2).
Asymptomatic apical periodontitis has traditionally
been classified histologically as either a periradicular
granuloma or a periradicular cyst. Various clinical
methods have been used to attempt to differentiate
these two clinically similar lesions.6166 The only accu-
rate way to distinguish these two entitles is by histolog-
ic examination.
Periradicular Granuloma. Nobuhara and del Rio
showed that 59.3% of the periradicular lesions were
granulomas, 22% cysts, 12% apical scars, and 6.7%
other pathoses.67 Histologically, the periradicular gran- Figure 5-3 Apical periodontitis (granuloma) in its more classic
uloma consists predominantly of granulation inflam- form. The central zone is dense with round cells (plasma cells and
matory tissue68 with many small capillaries, fibroblasts, small lymphocytes). Beyond is a circular layer of fibrous capsule.
Limited bone regeneration (arrow) can be clearly seen at outer
numerous connective tissue fibers, inflammatory infil- margin of capsule. Human tooth. Reproduced with permission
trate, and usually a connective tissue capsule (Figure from Matsumiya S. Atlas of oral pathology. Tokyo: Tokyo Dental
5-3). This tissue, replacing the periodontal ligament, College Press; 1955.
Figure 5-4 Histopathologic examination of apical periodontitis (granuloma) reveals A, the presence of many plasma cells (white arrow)
and lymphocytes (black arrow); B, cholesterol slits (black arrows); C, foam cells (black arrows); D, multinucleated giant cells (open arrows).
All of these features may not be seen in one specimen of a chronic periradicular lesion.
have also been demonstrated in these lesions.71,72 Local Effects of Asymptomatic Apical Periodontitis.
Epithelium in varying degrees of proliferation can be Bone and periodontal ligament can be replaced by
found in a high percentage of periradicular granulo- inflammatory tissue. This process is associated with
mas (Figure 5-5).69 formation of new vessels, fibroblasts, and sparse,
Periradicular Cyst. Histologic examination of a immature connective tissue fibers. As long as egress of
periradicular cyst shows a central cavity lined by stratified irritants from the root canal system to the periradicu-
squamous epithelium (Figure 5-6). This lining is usually lar tissues continues or macrophages fail to eliminate
incomplete and ulcerated. The lumen of the periradicu- the materials they have phagocytosed,73 destructive as
lar cyst contains a pale eosinophilic fluid and occasional- well as healing processes will occur simultaneously in
ly some cellular debris (Figure 5-7). The connective tissue asymptomatic apical lesions. The extent of the lesion
surrounding the epithelium contains the cellular and depends on the potency of the irritants within the root
extracellular elements of the periradicular granuloma. canal system and the activity level of defensive factors
Inflammatory cells are also present within the epithelial in this region. If a balance between these forces is main-
lining of this lesion. Histologic features of periradicular tained, the lesion continues in an asymptomatic man-
cysts are very similar to those of periradicular granulo- ner indefinitely. On the other hand, if the causative fac-
mas except for the presence of a central epithelium-lined tors overcome the defensive elements, a symptomatic
cavity filled with fluid or semisolid material. periradicular lesion may be superimposed on the
B
in turn, produces more soft and hard tissue necrosis. Figure 5-11 A, Localized abscess resulting from an incomplete
The suppuration process finds lines of least resistance root canal treatment on a maxillary lateral incisor. B, Cellulitis
and eventually perforates the cortical plate. When it caused by a maxillary first molar with necrotic pulp. (Courtesy of
Dr. Mohammad Baghai.)
reaches the soft tissue, the pressure on the periosteum
is relieved, usually with an abatement of symptoms.
Once this drainage through bone and mucosa is
obtained, suppurative apical periodontitis or an
asymptomatic periradicular abscess is established.
Asymptomatic Apical Abscess
Asymptomatic apical abscess (AAA), also referred to as
suppurative apical periodontitis, is associated with a
gradual egress of irritants from the root canal system
into the periradicular tissues and formation of an exu-
date. The quantity of irritants, their potency, and their
host resistance are all important factors in determining
the quantity of exudate formation and the clinical signs
and symptoms of the lesion. Asymptomatic apical
abscess is associated with either a continuously or
intermittently draining sinus tract. This is visually evi-
dent as a stoma on the oral mucosa (Figure 5-12) or
occasionally as a fistula on the skin of the face (Figure Figure 5-12 Apical abscess and its stoma. Initially, the abscess was
5-13). The exudate can also drain through the gingival asymptomatic, but when the opening of the sinus tract from the
sulcus of the involved tooth, mimicking a periodontal maxillary left central incisor became blocked, the accumulation of
lesion with a pocket. This is not a true periodontal drainage caused pain.
The healing of periradicular tissues after root canal Do different types of endodontic periradicular
treatment is often associated with formation and lesions have different patterns of healing? Possibly
organization of a fibrin clot, granulation tissue forma- there are variations, but this has not been conclusively
tion and maturation, subsidence of inflammation, and, demonstrated. Of the three general lesion typesgran-
finally, restoration of normal architecture of the peri- uloma, cyst, and abscessit is likely that the granulo-
odontal ligament. Since the inflammatory reactions are ma follows the pattern described above.99 The abscess
usually accompanied by microscopic and macroscopic may be slower; the exudates and bacteria must be
resorption of the hard tissues, bone and cementum cleared from the tissues before regeneration occurs. A
repair occurs as well. variation of the abscess, the sinus tract (intraoral and
Periradicular lesions repair from the periphery to extraoral) will heal following root canal treatment.100 It
the center. If the cortical plate is perforated by resorp- has been suggested that the periradicular cyst with a
tion, the healing process is partially periosteal in cavity that does not communicate with the root canal is
nature. Boyne and Harvey, after creating cortical plate less likely to resolve following root canal treatment101;
perforations in the jaws of humans, showed that labial this has yet to be proven.
defects measuring 5 to 8 mm in diameter healed com- There is some evidence that at least some lesions
pletely within 5 months.97 When they studied apical may heal with formation of scar tissue.102 Although the
defects measuring 9 to 12 mm, they found that these frequency of healing by scar tissue is unknown, it is
lesions had limited labial cortex formation and instead likely that it seldom occurs following root canal treat-
were filled with avascular fibrous connective tissue up ment, being much more common after periradicular
to 8 months following surgery. surgery on maxillary anterior teeth.103
If lesions have not involved the periosteum, the heal-
ing response will be endosteal, with formation of bony NONENDODONTIC PERIRADICULAR LESIONS
trabeculae extending inward from the walls of the lesion Bhaskar, in his textbook on radiographic interpreta-
toward the root surface. On the periphery, osteoblasts tion, listed 38 radiolucent lesions and other abnormal-
appear and elaborate bone matrix (osteoid), which grad- ities of the jaws.104 Three of these lesions, dental gran-
ually mineralizes as it matures. If cementum or dentin uloma, radicular cyst, and abscess, are categorized as
has been resorbed by the inflammation, remodeling and being related to necrotic pulps. In addition, Bhaskar
repair are by secondary cementum. identifies 16 radiopaque lesions of the jaws, 3 of which,
The last to form is likely the fibrous component inter- condensing osteitis, sclerosing osteomyelitis, and
posed between newly formed bone and the cemental root Garrs osteomyelitis, are also related to pulpal patho-
surface. These fibers have basically two orientations. One sis. The dentist must therefore differentiate between the
is a true periodontal ligament arrangement, whereas the endodontic and the nonendodontic lesions, ruling out
other is an alignment of collagen parallel to the root sur- those that trace their origin from nonpulp-related
face. Both orientations represent complete healing. sources. Additional confusion in radiographic diagno-
The sequence of events postendodontic treatment sis relates to normal radiolucent and radiopaque struc-
leading to complete repair of periradicular tissues, after tures that lie within or over apical regions.
inflammatory destruction of the periodontal ligament, Differential diagnosis of periradicular pathosis is
bone, or cementum, has not been validated. Most essential and, at times, confusing. There is a tendency
information is based on repair of extraction sites or for the clinician to assume that a radiolucency is an
healing of bone cavities following periradicular curet- endodontically related lesion and that root canal treat-
tage. These may or may not be accurate as to patterns ment is necessary without performing additional con-
of nonsurgical apical repair. A blood clot forms follow- firmatory tests. Avoid this pitfall!
ing extraction or apicoectomy, which becomes organ- The dentist must therefore be astute as well as
ized into recognizable granulation tissue. This tissue knowledgeable when diagnosing bony lesions. It is
contains endothelium-lined vascular spaces, vast num- important that teeth with sound pulps not be violated
bers of fibroblasts, and associated collagen fibers. The needlessly because of the mistaken notion that radiolu-
granulation tissue is infiltrated by neutrophils, lym- cencies in the apical region always represent endodon-
phocytes, and plasma cells. On the periphery of the tic pathema. The reverse is also true; endodontic
granulation tissue, osteoblasts and osteoclasts abound. lesions may mimic nonendodontic pathosis.
With maturation, the number of cells decreases, where- Significantly, most radiolucent lesions do indeed
as collagen increases. Ultimately, mature bone forms trace their origin to pulpal disease. Therefore, the den-
from the periphery toward the center.98 tist is likely to encounter many more endodontic
lesions, because of their sheer numbers, than other Routine periradicular or panographic films might
types of pathosis. However, many of the nonendodon- reveal its presence at the apex of adjacent teeth, some-
tic lesions mimic endodontic pathema, with similar times causing root resorption. An unusual variant is
symptoms and radiographic appearance.105 On the the circumferential dentigerous cyst (Figure 5-14). The
other hand, many of the nonendodontic lesions are tooth may erupt through the dentigerous cyst, with the
symptomless (as endodontic lesions frequently are) resulting radiolucency occurring periradicularly, thus
and are detected only on radiographs. To avoid errors, closely mimicking periradicular pathosis of pulp ori-
the dentist must approach all lesions with caution, gin.109 The dentigerous cyst occasionally may become
whether symptomatic or not. secondarily infected and inflamed, often via a pericoro-
This section will deal with lesions of the jaws cate- nal communication. The swelling and pain clinically
gorized as odontogenic or nonodontogenic in origin. resemble disease of pulpal origin.
Odontogenic lesions arise from remnants of odontoge- This cyst is readily differentiated from chronic apical
nesis (or the tooth-forming organ), either mesenchy- periodontitis or acute apical abscess in that the adjacent
mal or ectodermal in origin. Nonodontogenic lesions erupted tooth invariably demonstrates pulp vitality.
trace their origins to a variety of precursors and there- Lateral Periodontal Cyst. This uncommon cyst
fore are not as easily classified. arises at the lateral surface of a tooth, usually in the
Not all bony lesions that occur in the jaws will be mandibular premolar-canine area (Figure 5-15). This
discussed as many are extremely rare or do not ordi- lesion is currently thought to arise from remnants of
narily mimic endodontic pathosis. An oral pathology the dental lamina and probably represents the
text should be consulted for clinical features and intraosseous analog of the gingival cyst of the adult.110
histopathology of missing entities. Furthermore, the Clinically, the lesion is asymptomatic, and again the
lesions that are included are not discussed in detail. Of
primary concern are the clinical findings causing them
to resemble endodontic pathema, as well as those fac-
tors leading to accurate differential diagnosis.
Differentiating between lesions of endodontic and
nonendodontic origin is usually not difficult. Pulp
vitality testing, when done with accuracy, is the pri-
mary method of determination; nearly all nonen-
dodontic lesions are in the region of vital teeth, where-
as endodontic lesions are usually associated with pulp
necrosis, giving negative vitality responses. Except by
coincidence, nonendodontic lesions are rarely associat-
ed with pulpless teeth. Other significant radiographic
and clinical signs and symptoms, however, aid in dif-
ferential diagnosis.
Odontogenic Cysts
Dentigerous Cyst. Also called follicular cysts, dentiger-
ous cysts are derived histogenetically from the reduced
enamel epithelium of an impacted or embedded tooth.
Therefore, they are most often associated with the
crowns either of impacted third molars, maxillary
canines, or mandibular second premolars. The majori-
ty are found in the mandible.106,107 Although most
remain small and asymptomatic, dentigerous cysts
have the potential to become aggressive lesions.
Continued enlargement may involve large areas of the
jaws, particularly the mandible, with displacement of Figure 5-14 Circumferential dentigerous cyst developed around
the crown of an unerupted canine. The cyst may be enucleated (care
teeth and expansion of cortices.108 must be taken to avoid the incisor) and the canine brought into
Dentigerous cysts may be confused with endodontic position with an orthodontic appliance. (Courtesy of Dr. Russell
lesions by either radiographic or other clinical findings. Christensen.)
demonstrates lesions that are often multiple, usually induces resorption of the medullary bone surrounding
involve the mandibular incisors, and occur most often the apex, resulting in a radiolucent lesion closely mim-
in middle-aged African American women. However, icking a lesion of pulpal origin (Figure 5-17). During
they can and do occur elsewhere in the jaws and in any this stage of radiolucency, errors are frequently
race and at other ages. Their etiology is unknown. made,122 emphasizing the necessity of pulp testing.
Periradicular cemental dysplasia has an interesting Unlike apical periodontitis or an apical cyst, this new
evolution.121 The progression is from normal alveolar growth is free of inflammation. Furthermore, nerves
bone to bone resorption and fibrosis and finally to and vessels are unimpeded as they make their passage
dense, atypical reossification. The initial stage (oste- to and from the root canal.
olytic stage) is characterized histologically by a prolif- In time, cementoblasts differentiate within the soft
eration of fibroblasts and collagen fibers in the apical tissue, and a central focus of calcification appears
region of the periodontal ligament. The resultant mass (intermediate stage) (Figure 5-18). This deposition of
A B
C
Figure 5-17 A, Periradicular cemental dysplasia (osteofibrosis), initial stage. Pulps in both teeth are vital. B,
Transition to the second stage is developing. C, Biopsy of periradicular osteofibrosis, initial stage. Fibrous con-
nective tissue lesion has replaced cancellous bone. (Photomicrograph courtesy of Dr. S. N. Bhaskar and the
Walter Reed Army Institute of Research. US Army photograph.)
A B
Figure 5-18 A, Periradicular cemental dysplasia, intermediate stage, central incisor and canine. Slight calcification of the fibrotic lesion is
now developing. The pulps are vital. B, Biopsy of the intermediate stage with foci (arrows) of calcification appearing throughout the lesion.
(Photomicrograph courtesy of Dr. S. N. Bhaskar and the Walter Reed Army Institute of Research, US Army photograph.)
hard tissue may be continued over the years until near- ly a mandibular first molar.124 The tumor mass is often
ly all of the fibrous tissue is reossified. When this surrounded by a thin, radiolucent zone that is continu-
occurs, the evolution has reached its third and final ous with the periodontal ligament space. Histologically,
stage (mature stage) (Figure 5-19). The reossification the tumor shows fusion with the root cementum.
is characterized radiographically by increasing Differentiation between cementoblastoma and con-
radiopacity. densing osteitis is based on differences in radiographic
Problems of differential diagnosis arise in conjunc- appearance; condensing osteitis is diffuse, shows no
tion with the initial radiolucent stage of periradicular well-defined borders, and is associated with chronic
cemental dysplasia (see Figure 5-17). Clinically, the pulpal disease. Furthermore, the lamina dura and nor-
lesions are always asymptomatic, and the adjacent mal periodontal ligament space may remain intact in
teeth respond to vitality testing. Radiographically, an condensing osteitis.
intact lamina dura is usually (but not always) visible Cementifying and Ossifying Fibroma. The central
around the apices if carefully looking through the ossifying fibroma is a benign, neoplastic, fibro-osseous
radiolucency. lesion. Circumstantial evidence indicates that central
Osteoblastoma and Cementoblastoma. These are ossifying fibromas originate from elements of the peri-
apparent benign neoplasms and are closely related odontal ligament.120 Most of these lesions arise in the
lesions. Some believe that a cementoblastoma is, in periradicular region and therefore can be easily con-
reality, an osteoblastoma with an intimate relationship fused radiographically with endodontic periradicular
with the root (Figure 5-20). The benign cementoblas- lesions (Figure 5-21). They tend to occur in younger
toma (or true cementoma) is an uncommon neoplasm patients and in the premolar-molar region of the
thought to represent a neoplasm of cementoblasts.123 mandible. Because they are asymptomatic, the lesions
Radiographically, the lesion is characteristically associ- are frequently undetected. They attain a large size, often
ated and continuous with the roots of the teeth, usual- with visible expansion of the overlying cortex.
A B
Figure 5-19 A, Periradicular cemental dysplasia, mature stage, canine. Osseous calcification associated with vital pulp. Fibrotic stage is seen
at the periapex of the first premolar. B, Biopsy of the final stage with advanced, dense calcification. (Photomicrograph courtesy of Dr. S. N.
Bhaskar and the Walter Reed Army Institute of Research. US Army photograph.)
The central ossifying fibroma has a characteristic The lesion may manifest endodontic-like clinical
progression of radiologic findings. During the early symptoms. An ameloblastoma may cause expansion of
stage, which is osteolytic, bone is resorbed and the jaws or erode the cortical bone and invade adjacent
replaced by fibrous tissue. Ossifying fibromas usually soft tissue. It is then visible and detectable on palpa-
appear as solitary radiolucencies that may or may not tion. Some lesions are solid, whereas others are soft and
be in contact with the apices of adjacent teeth (Figure fluctuant. If the lesion has undergone cystic degenera-
5-22). Because the lesion is ossifying (or cementifying),
the lesion, with time, demonstrates calcified compo-
nents in its center. These components enlarge and coa-
lesce, until eventually most of the lesion appears
radiopaque (see Figure 5-22).
Differentiating the ossifying fibroma from periradic-
ular lesions is not difficult unless the dentist depends on
radiographic findings alone. Characteristically, the
pulps in the teeth in the region of the lesion are vital.
Final diagnosis is by excision and biopsy, which show
elements of calcified structures within the stroma.125
Odontogenic Tumors
Ameloblastoma. The ameloblastoma is a rare but
destructive lesion. It is a locally invasive and sometimes A
dangerous lesion classified as an odontogenic tumor. It is
usually painless and grows slowly. Clinically, it may
resemble a periradicular lesion, demonstrating similar
signs. As the lesion expands, it can cause displacement
and increased mobility of teeth (Figure 5-23).
Radiographically, it is usually multilocular but may
appear as a solitary lesion, frequently associated with the
apices of teeth, particularly in the mandibular posterior
region. Often there is associated root resorption.126
B
Figure 5-22 Central ossifying fibroma gradually calcifying with Figure 5-23 Two examples of ameloblastoma. A, Surgical specimen
time. The asymptomatic lesion discovered in a radiographic survey of infiltrating ameloblastoma of mandible. B, Unicystic ameloblas-
initially resembled endodontic pathosis. (Courtesy of Dr. Raymond toma. This solitary lesion has displaced teeth much as an apical cyst
J. Melrose.) would do. The teeth are vital. (Courtesy of Dr. Raymond J. Melrose.)
tion, straw-colored fluid may be aspirated, which gives lar radiolucency in the anterior-premolar region of the
the appearance of an apical cyst. mandible. Clinically, the lesion is usually asympto-
Again, the differential diagnosis depends on a more matic, but the involved region may be painful and
careful examination than radiographs alone. show bony expansion.123 Radiographically, it often
Radiographically and clinically, the ameloblastoma surrounds apices and occasionally may produce root
may resemble many other types of bony lesions, resorption or tooth displacement (Figure 5-24).
including periradicular lesions. The critical test is the Histologically, the stroma is characterized by fibroblas-
vitality of pulps of adjacent teeth. Unless the tic tissue with foci of hemorrhage, many vascular
ameloblastoma has caused significant damage by spaces, and concentrations of multinucleated giant
invading and disrupting sensory nerves (which is sel- cells (Figure 5-25). Significantly and diagnostically, the
dom), the teeth will respond to pulp testing. pulps are usually vital, although the teeth are occasion-
ally nonresponsive, apparently because of sensory
Nonodontogenic Lesions nerve damage.
Central Giant Cell Granuloma. Of unknown eti- Because the pulps of adjacent teeth often have their
ology, the central giant cell granuloma is an expansile blood supply interrupted during curettage of the
destructive lesion of the bone.127 It most commonly lesion, root canal treatment is often necessary before or
occurs in children and young adult females and after surgical removal.
appears radiographically as a unilocular or multilocu- Nasopalatine Duct Cyst. Also known as the inci-
sive canal cyst and median anterior maxillary cyst, the
nasopalatine duct cyst is one of the more common
pathologic entities arising in the anterior region of the
maxilla. Because of its location, radiographic appear-
ance, and symptoms, it is easily confused with a peri-
radicular lesion (Figure 5-26). It arises from remnants
of the embryologic nasopalatine duct and so is consid-
ered a developmental cyst.
Clinically, the lesion is usually asymptomatic but may
show swelling or, if secondarily infected, discharge of pus
in the incisive papilla region.128 Radiographically, a
well-defined radiolucent area is seen interradicularly or
apically to the maxillary central incisors. It is often heart
shaped owing to superimposition of the anterior nasal
Figure 5-24 Central giant cell granuloma. A relatively smooth Figure 5-25 Central giant cell granulomarelatively loose con-
radiolucent lesion in the anterior region of the mandible. No nective tissue with numerous fibroblasts and a few giant cells (white
resorption or displacement of teeth is noted. The teeth responded arrows).
to vitality tests. (Courtesy of the Department of Oral Pathology,
Loma Linda University.)
A B
Figure 5-27 Nasopalatine duct cyst. A, A radiolucent lesion was noted near the apex of the vital maxillary central incisor (open arrows).
B, By change of angulation, the radiolucent area moves between the two central incisors (white arrows). The lesion was asymptomatic.
A B
Figure 5-29 Two examples of a so-called globulomaxillary cyst. A, Although having every appearance of a true apical cyst, this lesion is
associated with vital anterior teeth. This may be a true globulomaxillary cyst. (Courtesy of Dr. Richard E. Walton.) B, Necrotic pulp in the
lateral incisor with dens en dente. The resultant lesion simulates a globulomaxillary cyst and is a frequent occurrence with anomalous inci-
sors. (Courtesy of Dr. Raymond J. Melrose.)
Figure 5-32 Metastatic breast cancer. All three teeth are nonre-
sponsive to pulp testing. Unusual chisel edge and moth-eaten
Figure 5-31 Vestibular-buccal swelling from metastatic breast resorption are not typical of inflammatory osseous lesion. A biopsy
cancer. Appearance and symptoms can be confused with apical proved lesion malignant. (Courtesy of Drs. Raymond J. Melrose and
abscess. (Courtesy of Drs. Raymond J. Melrose and Albert Abrams.) Albert Abrams.)
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Chapter 6
ENDODONTIC
DIAGNOSTIC PROCEDURES
John I. Ingle, Geoffrey S. Heithersay, Gary R. Hartwell, Albert C. Goerig,
F. James Marshall, Robert M. Krasny, Alfred L. Frank, and Cyril Gaum
For I seek the truth by which no man has ever been harmed. A dentist can develop a number of assets to become
Marcus Aurelius, Meditations VI. 21, 173 AD a successful diagnostician. The most important of these
are knowledge, interest, intuition, curiosity, and
Before initiating treatment, one must first assemble patience. The successful diagnostician must also have
collective information regarding signs, symptoms, and acute senses and the necessary equipment for diagnosis.
history. That information is then combined with
results from the clinical examination and tests. This Knowledge
process is diagnosis. Stated another way, diagnosis is Primarily, a dentist must depend on himself, not the
the procedure of accepting a patient, recognizing that laboratory. Therefore, knowledge is the most impor-
he has a problem, determining the cause of the prob- tant asset the dentist must possess. This includes famil-
lem, and developing a treatment plan that will solve or iarity with all local orofacial causes of pain, as well as
alleviate the problem. numerous systemic, neurogenic, and psychological
The diagnostician must have a thorough knowl- causes. In addition, the dentist must be aware of the
edge of examination procedurespercussion, palpa- many physical, perceptual, emotional, and behavioral
tion, probing, and pulp testing; a knowledge of patho- changes brought about by chronic pain. He must know
sis and its radiographic and clinical manifestations; that constant overwhelming pain can affect the func-
an awareness of the various modalities of treatment; tion of every organ of the body. Chronic pain patients
and, above all, a questioning mind. To be added to can develop increased blood pressure, heart rate, kid-
these critical skills is the most basic skill of all, listen- ney function, decreased bowel activity, and hormone
ing to the patient. levels. They can have many symptoms, such as nausea,
Of all of the important diagnostic tools, the art of vomiting, photophobia, tinnitus, and vertigo. The
listening is the most underrated. Yet careful and atten- astute clinician gathers knowledge about the patient
tive listening establishes patient-dentist rapport, and his problem through a thorough history and an
understanding, and trust. Such a relationship also examination. The history and examination include
enhances the patients reliability as a historian.1 evaluating the physical, emotional, behavioral, and per-
ceptual aspects of the patients pain experience.
REQUIREMENTS OF A DIAGNOSTICIAN Under knowledge must also be listed the important
Diagnosis is a personal and cognitive experience; there- asset of knowing when and where to refer the patient
fore, many of the qualities of a good diagnostician are of for additional consultation. This comes with experi-
an interpersonal nature and are based on knowledge, ence and the help of physicians, psychologists, and fel-
experience, and diagnostic tools. Diagnosing orofacial low dentists who may be depended on to assist in diag-
disease is similar to other medical diagnosis. Pulp tests, nosis. Often the patient is referred because examina-
radiographs, percussion, palpation, and other tests and tion reveals a problem clearly in the province of the
procedures can facilitate the diagnosing of dental/facial neurologist or otolaryngologist. Sometimes the patient
disease, just as the electrocardiograph, electroencephalo- is referred because the examiner has exhausted his
graph, echocardiograph, computed axial tomographic knowledge and needs help in diagnosis. The recogni-
and magnetic resonance imaging scan, and a host of tion of fallibility and limitationknowing when to yell
other radiographs can facilitate medical diagnosis. for helpis also a major asset to the dentist.
To the best of my knowledge, all of the preceding answers are true and correct. If I ever have any change in my health, or if my medicines change,
I will inform the doctor of dentistry at the next appointment without fail.
This comprehensive medical history responds to contemporary advances in physical evaluation and to increasing malpractice claims.
*Reproduced with permission from McCarthy FM. A new patient administered history developed for dentistry. J Am Dent Assoc 1985;111:595.
*Used to categorize patients following history and examination. Classification should be entered prominently in chart. Assigning risk from
treatment and level of clinical management follows classification. American Society of Anesthesiologists. New classification of physical sta-
tus. Anesthesiology 1963;24:111.
with information about the patients general health is long-standing, proceed with detailed questions about
(medical history) and the examination results. past episodes of pain or swelling and any previous
treatment performed to remedy the condition.
Chief Complaint Pain is frequently the main component of the
The chief complaint, usually in the patients own patients complaint. A history of pain that persists
words, is a description of the dental problem for which without exacerbation may indicate a problem not of
the patient seeks care. The verbal complaint may be dental origin. If the chief complaint is toothache but
accompanied by the patient pointing to the general the symptoms are too vague to establish a diagnosis,
area of the problem. analgesics can be prescribed to help the patient tolerate
After establishment and recording of the chief com- the pain until the toothache localizes. If the patient
plaint, the examination process is continued by obtain- arrives self-medicated with analgesics or sedatives, a
ing a history of the present illness. diagnosis may be difficult to establish.3
A patient in acute distress should undergo diagnosis The initial questions should help establish two basic
and examination as quickly as possible so the chief components of pain: time (chronicity) and severity (or
complaint may be treated as expeditiously as possible. intensity). Start by asking such questions as How long
At a later time, when the patient is pain free and more have you had this problem? How painful is it? and
rational, a complete treatment plan may be established. How often does it hurt? Continue the questioning
No treatment should be rendered unless the examiner with When does it hurt? When does it go away?
is certain of the diagnosis. Patients with severe pain What makes it hurt? What makes it hurt worse?
from pulpitis have difficulty in cooperating with the and What makes it hurt less or go away?
diagnostic procedures, but until the diagnosis has been A history of painful responses to thermal changes
made and the correct tooth identified, treatment must suggests a problem of pulpal origin and will need to be
not be started (see chapter 7). followed up with clinical tests, using the thermal test
that would most closely duplicate the patients com-
Present Dental Illness plaint: use ice if the complaint is pain with cold, and
A history of the present illness should indicate the use a hot stimulus if the complaint is pain with such
severity and the urgency of the problem. If the problem things as hot drinks.4 It could also be important to
learn that a tooth has been sensitive to thermal changes The type and number of past dental treatments should
but no longer responds to such stimuli; this would reveal the degree of sophistication of previous therapy
indicate that the tooth may have a pulp that is now and help in evaluating the expectations of the patient as
necrotic.5 well. The presence of obvious dental neglect or the
A history of painful response to eating and biting or unwillingness of the patient to have a pulpless tooth
pain on pressing the gingiva is also helpful. Minor sen- restored may rule out endodontic therapy.
sitivities or swellings, very noticeable to the patient, can The question, What kind of treatment have you
initially be overlooked by the examiner. These may had? might elicit a history of pulp capping, deep fill-
prove to be very important diagnostic clues and should ings with sedative bases, or indirect pulp caps. These
be noted. A collection of data such as that shown in teeth, as well as those that have received impact trauma,
Figure 6-1 is helpful in directing the examination pro- may exhibit calcific metamorphosis or dystrophic cal-
cedures and sometimes in pinpointing the problem. cifications and may be a difficult endodontic treatment
B
Figure 6-1 A, Chief complaint of vague discomfort directed attention to an incomplete root canal filling. However, the examination was
redirected to calculus and periodontal disease, when it was revealed that the treatment was 50 years old. B, Radiograph taken immediately
after filling suggests gross overfill (arrow). C, An occlusal radiograph, however, shows a sialolith, that was not initially suspected (arrow).
Repeated surgery for this condition had not been elicited in the past dental history. Reproduced from Marshall FJ. Dent Clin North Am
1979;23:495.
Figure 6-2 A, Mandibular incisors with sclerosed canals and tiple occurrences of caries (stressed pulp) should be
chronic apical periodontitis. Surgical treatment was required. B, evaluated carefully with respect to pulpal status before
Same case. Dark teeth caused the patient to seek treatment. If procedures such as full crowns or bridge abutment
immediate post-trauma and follow-up radiographs had been made restorations are initiated. Root canal therapy prior to
regularly, nonsurgical therapy could have been attempted when
change was first noted. Reproduced from Marshall FJ. Dent Clin
restorations in such teeth is often indicated. The ques-
North Am 1979;23:495. tion, How recently has this tooth or area been treat-
ed? may provide information that the problem of
thermal sensitivity is merely a reaction to a recently
placed restoration. If the pain is of low intensity, a
problem (Figure 6-2). Although a positive and accurate patient may tolerate it in the hope that it will subside.
answer may not result, the question will prompt a clos- Pain existing for several months may have become part
er look at radiographs for the presence or absence of of the patients lifestyle.7
cement bases or for recurrent caries or caries remaining A history of long-standing, severe pain should raise
under restorations (Figure 6-3). suspicion that the condition may be other than pulpal
Full-crown restorations should also raise questions to in origin. Additional examinations for myofascial or
the patient regarding wet or dry drilling. Dry neurologic pain, as well as cardiac referred pain or pos-
drilling may result in an increased incidence of inflam- sibly psychogenic pain, should be considered. A more
mation and even internal resorption (see Figure 4-44). detailed discussion of this subject is found in chapter 8.
Patients who have undergone orthodontic treatment Finally, the patient must be asked about past reac-
may have areas of resorption or pulpal changes. In the tions to dental procedures; to pain, both dental and
past decade, there has been an increased interest in adult general; and to expectations for treatment. A patient
orthodontics, and recent studies indicate that the adult with a history of low pain threshold and strong anal-
pulp may be more susceptible than younger pulps to gesic dependency, as well as many previous attempts to
such iatral trauma6 (Figure 6-4). solve the problem, may require special treatment or
The question, How many times has this tooth or referral.
have these teeth been treated? is also pertinent. A It should be noted that history taking is a process of
tooth with a history of repeated restorations and mul- questions and answers and that many questions are
The vital signs may be recorded by any trained Cancer Screen (soft tissue examination: lumps,
member of the office team. However, abnormal values bumps, white spots). Every new patient must be rou-
must be evaluated by the doctor. The person of first tinely screened for cancer and other soft tissue non-
contact should also record, for later evaluation, any odontogenic conditions as part of the examination. And
additional observations of abnormalities such as they must be informed of the results! This examination
breathlessness, color change, altered gait, or unusual should include a survey of the face, lips, neck, and intra-
body movements observed during the initial meeting. oral soft tissues. When such examinations are made
Blood Pressure (normal: 120/80 mm Hg for persons routinely, without secrecy, they will usually dispel the
under age 60; 140/90 mm /Hg for persons over age 60). unstated fears of the cancerphobe and add to the confi-
Routine use of the sphygmomanometer not only estab- dence and rapport of all patients with their dentists. The
lishes a baseline blood pressure but occasionally brings sooner this examination is completed the better.
to light unsuspected cases of hypertension in patients It is sometimes argued that dentists are liable if they
who are not regularly seeing a physician or are not inform patients that they are performing an examina-
maintaining prescribed regimens of therapy. Halpern tion and then miss finding disease when it is present. In
reported that only 18% of the dental clinic patients fact, dentists are even more liable if they miss reporting
attending Temple University Dental School were seeing the disease because they have not made an examination.
their physicians.8 At times, however, elevated blood Extraorally, a cancer survey includes palpation for
pressure is caused only by the stress and anxiety of the masses and examination for asymmetry and color
moment and can be dealt with by reassurance or, if nec- changes. Intraorally, this examination is repeated with
essary, pretreatment sedation. Even more important, the additional care of directed lighting and of moving
however, is the emphasis that this face-to-face proce- the tongue in such a manner so that all areas can be
dure places on an examination. Both the patient and the clearly seen (Table 6-3). Detailed procedures are pre-
doctor are inclined to be more serious in their questions sented elsewhere.13
and answers when the examination begins with blood
pressure records. It must be stressed that no patient, Extraoral Examination
with or without a dental emergency, should be treated Inflammatory changes originating intraorally and
when his diastolic blood pressure is over 100 mm.11 observable extraorally may indicate a serious, spread-
Pulse Rate and Respiration (normal: pulse, 60 to 100 ing problem.14 The patient must be examined for
beats/minute; respiration, 16 to 18 breaths per minute). asymmetries, localized swelling, changes in color or
When these examinations are added to the recording of bruises, abrasions, cuts or scars, and similar signs of
blood pressure, the dentist increases the opportunity to disease, trauma, or previous treatment. Positive find-
know the patient better. These examinations also show ings combined with the chief complaint and informa-
the patient, by physical contact, how further examina- tion about past injuries or previous treatments to teeth
tion will proceeddeliberately, gently, and completely. or jaws will begin to clarify the extent of the patients
Pulse and respiration rates may also be elevated owing to problem.
stress and anxiety; in fact, these signs may be even better The extraoral examination includes the face, lips,
indicators of stress than is blood pressure. Tests with and neck, which may need to be palpated if the patient
markedly positive findings should be repeated later in reports soreness or if there are apparent areas of
the appointment or at a subsequent appointment. inflammation. Painful and/or enlarged lymph nodes
Temperature (normal: body temperature, 98.6F are of particular importance. They denote the spread of
[37C]). The taking and recording of body tempera-
ture is a simple, significant procedure. An elevated tem-
perature (fever) is one indication of a total body reac- Table 6-3 Oral Cancer Warning Signals*
tion to inflammatory disease. If the body temperature
is not elevated, one can assume that the body is man- Swelling, lump, or growth anywhere in or about the mouth
aging its defenses well, that whatever the local signs are White, scaly patches inside the mouth
(pain, swelling, abscess formation, etc), systemic treat- Any sore that does not heal
ment, with its attendant risks, will likely not be Numbness or pain anywhere in the mouth area
required. A temperature above 98.6 but less than 100F
Repeated bleeding in the mouth without cause
indicates localized disease.12 Localized disease can usu-
ally be treated by removing the cause (eg, cleaning the *Open Wide. Reproduced with permission from the American
root canal) and/or incision and drainage. Cancer Society, New York.
inflammation as well as possible malignant disease. The especially true following an accident. In fact, the gener-
extent and manner of jaw opening can provide infor- al state and care of the entire mouth must be noted
mation about possible myofascial pain and dysfunc- along with the particular tooths restorability and
tion.15 The temporomandibular joint should be exam- strategic importance.
ined during function for sensitivity to palpation, joint If the patients chief complaint includes symptoms
noise, and irregular movement.16 that occur following specific events (eg, chewing,
drinking cold liquids), the specific intraoral examina-
Intraoral Examination tion should include tests that duplicate or reproduce
The intraoral examination is begun with a general eval- these symptoms. For example, if the chief complaint is
uation of the oral structures. The lips and cheeks are pain with hot liquids, the clinical tests may include test-
retracted while the teeth are in occlusal contact and the ing the suspected tooth with a hot stimulus. A positive
oral vestibules and buccal mucosa are examined for response (development of the chief complaint) will be
localized swelling and sinus tract or color changes. With important evidence in establishing the diagnosis.
the patients jaws apart, the dentist should evaluate in a In the following sections, various tests will be
similar manner the lingual and palatal soft tissues. Also, described, detailing how to perform them and how to
the presence of tori should be noted. Finally, as part of evaluate the results. The correct diagnosis can be estab-
the general inspection, carious lesions, discolorations, lished more readily the more information that is devel-
and other obvious abnormalities associated with the oped from all sources: history, clinical examination,
teeth, including loss of teeth and presence of supernu- radiographic evaluation, and clinical tests.
merary or retained deciduous teeth, should be noted. Coronal Evaluation. For psychological reasons
Often the particular tooth causing the complaint is and to expedite treatment, the most obviously affected
readily noted during this visual examination if it has tooth is examined first, particularly when the patient,
not already been pointed out by the patient. the history, or the general examination calls attention
Complaints associated with discolored or fractured to a certain tooth.
teeth, teeth with gross caries or large restorations, and Using a mouth mirror and an explorer, and possibly
teeth restored by full coverage are for the most part a fiber-optic light source, the dentist carefully and thor-
readily located. True puzzlement begins when the oughly examines the suspected tooth or teeth for caries,
complaint centers on teeth fully crowned and part of defective restorations, discoloration, enamel loss, or
extensive bridges or splints, or when only a few teeth defects that allow direct passage of stimuli to the pulp.
are restored, and then only with minimal restorations. Sometimes sealing off such leakage with temporary
Transillumination with a fiber-optic light, directed cements or periodontal dressings can be diagnostic
through the crowns of teeth, can add further informa- (Figure 6-5). Vertical and horizontal fractures located by
tion.17 By this method, a pulpless tooth that is not transillumination should be further investigated by hav-
noticeably discolored may show a gross difference in
translucency when the shadow produced on a mirror is
compared to that of adjacent teeth. Transillumination
may also locate teeth with vertical cracks or fractures.
If the involved tooth is not readily identified, it may
be necessary to thoroughly examine all of the teeth in
the half arch or opposing arch, depending on how
specifically the patient can localize the area of pain.
Although the size of a carious lesion or the presence of
a crown or large restoration may point to the involved
tooth, the symptoms may be referred pain or pain from
an adjoining tooth with problems. Adjacent teeth with
large restorations or crowns can be assumed to be
equally at risk. Regardless of the presence or absence of
findings, the patients premonitions and descriptions Figure 6-5 Zinc oxideeugenol temporary cement packed buccal-
ly and lingually to seal margins of a porcelain-fused-to-metal crown
should not be ignored in favor of what appears to be
against external stimulus (leakage). If the patients complaint stops,
obvious. For the record and for the possibility of addi- then the margins can be permanently sealed or the crown remade.
tional later treatment, the condition of all teeth in the This technique is particularly helpful when several teeth are
immediate vicinity should also be recorded. This is crowned. (Courtesy of Dr. F. James Marshall.)
ing the patient bite on some firm object such as the pain to a cold stimulus might be considered in cases in
Tooth Slooth (Laguna Niguel, Calif.), or a wet cotton which the patient clearly feels that the pain is still pres-
roll.18 Occlusal wear facets and parafunctional patterns ent several seconds after stimulus removal. In testing, if
are also sought out, as is tooth mobility. the pain lingers, that is taken as evidence for irre-
versible pulpitis; if pain subsides immediately after
Pulpal Evaluation stimulus removal, hypersensitivity or reversible pulpi-
The clinical condition of the pulp can be evaluated by tis is the more likely diagnosis.
thermal stimuli, percussion, palpation, and vitality tests. Cold as a test for pulp vitality (pulp necrosis versus
Generally, pain of endodontic origin results from pulp vital pulp) is probably not entirely reliable since teeth
inflammation that spreads from the coronal pulp api- with calcified pulp spaces may have vital pulps, but cold
cally to the periodontal ligament, which then spreads to stimuli may not be able to excite the nerve endings owing
the periosteum overlying the apical bone and beyond. to the insulating effect of tertiary/irritation dentin.
Pulpal and periradicular symptoms, therefore, some- Cold testing can be made with an air blast, a cold
times combine, making pulpal assessment difficult. drink, an ice stick, ethyl chloride or Fluori-Methane
The purpose of evaluating the pulpal condition is to (Gebauer Chemical Co., Cleveland, Ohio) sprayed on a
arrive at a diagnosisnamely, the nature of the disease cotton swab, or a carbon dioxide (CO2) dry ice stick.21
involving the pulp. After determining the diagnosis, Fuss et al. found CO2 snow or Fluori-Methane more
there are specific treatment options for each pulpal reliable than ethyl chloride or an ice stick.22 Rickoff et al.
condition. Irreversible pulpitis and pulp necrosis reported that CO2 snow applied to a tooth for as long as
require removal of the pulp (pulp extirpation and root 5 minutes did not jeopardize the health of the pulp,23
canal treatment, or extraction of the tooth), whereas a nor does it damage the surface of the enamel.24 On the
tooth with a normal pulp or with reversible pulpitis other hand, CO2 does cause pitting of the surface
may be treated by preserving the pulp (vital pulp ther- when applied to porcelain on porcelain-fused-to-metal
apy). The various methods of pulpal evaluation, then, restorations for as little as 5.4 seconds.25
do not dictate treatment but provide information that The CO2 dry ice stick is preferred for testing because
can be used with other information (history and radi- it does not affect adjacent teeth, whereas the air blast and
ographs) to establish a diagnosis. Pulp tests alone are the ice stick do, and because it gives an intense, repro-
usually not adequate for establishing a diagnosis but ducible response26 (Figure 6-6). This has been confirmed
can provide very useful information.19,20 by Peters et al. in their studies on the effects of CO2 used
as a pulpal test.24,2729 Small icicles can be made in the
Clinical Endodontic Tests office by freezing water in anesthetic needle covers.
There are several ways to obtain information about the When testing with a cold stimulus, one must begin
condition of a tooths pulp and supporting structures. with the most posterior tooth and advance toward the
Probably no one test is sufficient in itself; the results of anterior teeth. Such a sequence will prevent melting ice
several tests often have to be obtained to have enough water from dripping in a posterior direction and possibly
information to support a likely diagnosis or perhaps a excite a tooth not yet tested, giving a false response.
list of differential diagnoses. Hot testing can be made with a stick of heated
Thermal Tests. Two types of thermal tests are gutta-percha or hot water. Both have advantages, but hot
available, cold and hot stimuli. Neither is totally reliable water may be preferable because it allows simulation of
in all cases, but both can provide very useful informa- the clinical situation and also may be more effective in
tion in many cases of pulpal involvement. penetrating porcelain-fused-to-metal crowns.30
The cold test may be used in differentiating between The use of a hot stimulus in the form of hot water
reversible and irreversible pulpitis and in identifying can help locate a symptomatic tooth with a necrotic (or
teeth with necrotic pulps. It can also alleviate pain dying) pulp. The effect tends to be lingering, and the
brought on by hot or warm stimuli, a finding that main reason for using the test is to localize which tooth
patients sometimes discover can provide them with is symptomatic. Often other evidence (patients own
much relief. opinion, radiographs, history, clinical appearance) will
When cold is used to differentiate between reversible indicate which tooth is suspected. This tooth is then
and irreversible pulpitis, one must try to determine if isolated with a rubber dam so the hot water will flow
the effect of stimulus application produces a lingering only around the tooth. A positive response of pain,
effect or if the pain subsides immediately on removal of similar to the chief complaint, provides the informa-
the stimulus from the tooth. The lingering quality of tion needed to identify the problem tooth.
A B
Figure 6-8 Use of an electric pulp tester. A, Posterior teeth should be isolated and dried. Mylar strips can be used to separate connecting
metallic fillings. Using toothpaste as a conductor, contact should be made on the occlusal third. B, Isolated and dried anterior teeth are con-
tacted on the incisal third to avoid false stimulation of gingival tissue. C, Vitality Scanner pulp tester. To complete the circuit, the patient may
touch the metal handle. D, Digitest pulp tester with lip contact to complete circuit. Both pulp testers have a digital readout. The difference
lies in size and price. A and B reproduced with permission from Marshall FJ. Dent Clin North Am 1979;23:495. C courtesy of Analytic
Technology. D courtesy of Parkell Products.
to use the same pulp tester each time for more accurate without anesthesia, through the restorative material,
comparison. Being able to quantify results numerically until the dentin is reached. During preparation, pene-
is a decided advantage of EPT over thermal testing. tration to the dentin may be sufficient enough to elicit
Multirooted teeth may need to be tested by placing a response. If not, the probe is placed directly on dentin
the electrode on more than one crown location. It may and the response noted. To avoid contacting the metal
happen that two areas on a molar will give a negative of the crown, a tiny piece of spaghetti tubing can be
response, but a positive test within the normal range used to insulate the tester probe. Analytic Technology
may be gained in another area. This may indicate that also makes a Mini-Tip for this purpose, or a small
the pulp in two canals is necrotic, whereas the pulp in instrument such as an endodontic file may be used as a
the third canal is still vital. bridging device.48
If CO2 dry ice testing is not possible and if it is Precautions in Use of an Electric Pulp Tester. It
imperative that a tooth fully covered by gold or porce- has been suggested that using an electric pulp tester on
lain be electrically pulp tested, a cavity is prepared patients who have an indwelling cardiac pacemaker is
contraindicated. After testing the effect of electric pulp pain should disappear, even when it is referred to the
testers on dogs with artificial pacemakers, Woolley and opposite arch.
associates concluded that currents of the magnitude of Test Cavity. This test is often a last resort in testing
5 to 20 milliamps are sufficient to modify normal pace- for pulp vitality. It is important to explain the procedure
maker function.49 After testing one battery-powered to the patient because it must be done without anesthe-
device and three using line current, they found that sia. Make a preparation through the enamel or the exist-
only one caused interference with pacemaker action. ing restoration until the dentin is reached. If the pulp is
They also warned against devices such as desensitizers vital, the heat from the bur will probably generate a
and electrosurgical units that could produce unknown response from the patient; however, it may not necessar-
current leaks, as one of the pulp testers did. ily be an accurate indication of the degree of pulpal
Liquid Crystal Testing. Cholesteric liquid crystals inflammation. As with other tests, the cavity test must be
have been used by investigators50 to show the difference used in conjunction with the history and other testing
in tooth temperature between teeth with vital (hotter) procedures and not used as the sole determinant.
pulps and necrotic (cooler) pulps. The laser Doppler
flowmeter has also been shown to measure pulpal The Stressed Pulp
blood flow and thus the degree of vitality.5153 Already Abou-Rass has directed the attention of the profession
used in medicine (retina, renal cortex), this experimen- to what he calls the stressed pulp.5 This is the pulp
tal device might well spell the difference between that over the years has been stressed by both disease
reversible and irreversible pulpitisthe stressed pulp, and treatment (caries and periodontis; trauma
if you will. impact, occlusal, and iatral; chemicalscements,
The Hughes Probeye camera, which is capable of resins, and amalgams). This is the tooth that has
detecting temperature changes as small as 0.1C, has also decayed and been restored then re-restored, cut down,
been used to measure pulp vitality experimentally.54 All heated upall of the insults a pulp is subjected to over
three of these methods measure blood flow in the pulp, a long span of time.
the true measurement of pulpal status. One may emerge In addition, when the tooth is now ready to be used
as the pulp tester of the future. as an abutment for an important partial denture, fixed
Occlusal Pressure Test. A frequent patient com- or removable, still more iatral insult follows. Careful as
plaint is pain on biting or chewing. The causes for such one might be, the tooth must still be reduced some
symptoms include apical periodontitis, apical abscess, more, heated up, cooled off, and injured by impres-
and incomplete tooth fractures (infractions). A clinical sions, try-ins, and temporaries. The final insult is per-
test that simulates the chief complaint is the occlusal manent cementation followed by microleakage.
pressure test (or biting test). Several methods exist, Is it any wonder that a number of these stressed
such as biting on an orangewood stick, a Burlew rub- pulps finally give up by either aching and dying or just
ber disk, or a wet cotton roll. All have the ability to quietly dying? But the tragedy is that the tooth is now
simulate a bolus of food and allow pressure on the covered by a beautiful new restoration that will have to
occlusal surfaces. be weakened or destroyed to reach the ailing pulp.
The orangewood stick, the Tooth Slooth, and Burlew Would it not have been better, asked Abou-Rass, to
disks allow pinpoint testing of individual cusp areas, have determined the quality of life of the pulp before
whereas the wet cotton roll has the advantage of adapt- treatment and have taken action before, not after, the
ing to the occlusal surface, allowing for pressure over the final commitment has been made?5
entire occlusal table. This test is useful in identifying How does one determine which pulps are stressed?
teeth with symptoms of apical periodontitis, abscess, or By taking a careful history and examination, of course.
cracks. An interesting clinical observation in patients The dentist must consider the patients lengthy report
with tooth infractions (cracked tooth syndrome) is pain on this particular tooth, the radiographic outline of the
often experienced when biting force is released rather pulp cavity, and the examination findings. The exami-
than during the downward chewing motion. nation includes transilluminating; probing; percussing;
Anesthetic Test. Pain in the oral cavity is frequently examining for cracks, crazing, and abrasion; and the
referred from one tooth to an adjacent one or even from response to pulp testing, thermal and electrical.
one quadrant to the opposing one. The anesthetic test Any negative results should be viewed with suspicion,
can help identify the quadrant from whence the focus of including past trauma, orthodontic movement, multiple
pain originates. The suspected tooth should be anes- or deep restorations, poor systemic health, irradiation in
thetized, and, if the diagnosis is correct, the referred the area, tooth coloration, structural cracks, defective
restorations, condensing osteitis (see Figure 6-49), pulp is determined by the amount of bony support, the
stones, irritation dentin, narrow canals, nearby pins, health of that support, and the health of the overlying
pulp capping, delayed response to heat and cold, or even soft tissue. Examination alone cannot guarantee the
a negative response to the electric pulp tester. All of these future health of these tissues, but usually it can deter-
data must then be considered and acted on before com- mine existing disease. Isolated bone loss or tooth mobil-
mitting this tooth with this pulp to the forthcoming ity may or may not signify periodontal disease. It may
stressful events. be owing to periradicular disease of pulpal origin, or it
If one determines that a pulp has been severely may be combined periodontal-endodontal disease.55
stressed, would it not be better to intentionally remove Generalized bone loss of periodontal disease will defi-
the pulp and perform root canal therapy before pro- nitely affect prognosis and therefore the treatment plan.
ceeding with treatment, rather than having to cut back As part of the examination, probe the sulcus of the
through a fine restoration to perform the inevitable? tooth or teeth in question and record the pocket meas-
Clinical judgment comes with clinical experience. urements. Also test for mobility and record the data
But when dealing with pulps that have received repeat- using a system of 0 through 3. Grade 0 means normal
ed previous injury and survived with diminished mobility, grade 1 slight mobility, grade 2 marked mobil-
responses and lessened repair potential,5 it might be ity, and grade 3 mobility and depressable. Also record if
wiser to act sooner rather than later. bleeding occurs on probing. Particular note should be
made of palatal grooves in single rooted teeth (Figure 6-
Periodontal Evaluation 9), furcas in multirooted teeth, and other anomalies
No dental examination is complete without careful eval- (enamel projections, etc), as these may aggravate gingi-
uation of the teeths periodontal support. Periodontal val conditions and make for unstable future periodontal
probing and recording pocket depths provide informa- health. These examinations will establish approximate
tion with respect to possible etiology and prognosis (see bone levels and the crown-root ratio. The presence of 3
following sections). to 5 mm pockets of a first-degree mobility indicates
There is little question that pulpal necrosis can lead moderate periodontitis (Figure 6-10). When this is
to loss of periodontal support. Whether periodontal found, the entire mouth should be screened for peri-
disease can cause pulpal degeneration is a question not odontal disease and treated accordingly.56
clearly answered. There is agreement, however, that a Pockets deeper than 5 mm, or mobility graded 2 or
potential interaction exists between the pulp and peri- 3, indicate severe periodontitis, and periodontal
odontium. For the purposes of endodontic treatment treatment is imperative. Referral to a periodontist
of a single tooth, probing may be limited to the tooth should be considered. Regardless of the extent of the
involved and at least the adjacent teeth. As part of a periodontal disease or who renders the treatment, the
total oral examination, all teeth should be included in patient must be advised of the effect that periodontal
the probing evaluation. The number of probing loca- disease can have on the prognosis for endodontic ther-
tions may vary depending on the tooths location. Four apy. Hiatt reported 20-year follow-up on two cases
to six areas surrounding the tooth should provide a involving a number of teeth treated with combined
good picture of periodontal support. Gingival and sul- periodontal/endodontal therapy. Only one tooth was
cular bleeding and drainage, along with the presence of lost, because of root resorption.57
plaque and calculus, should also be noted.
Restorability
FACTORS INFLUENCING PROGNOSIS The restorability of a tooth requiring endodontic
Endodontic diagnosis should not be the sole determinant treatment depends on the amount of sound tooth
of treatment planning. Other factors contribute to deter- structure remaining and the effect that the restoration
mine whether a suspicious tooth should be restored or a will have on the periodontal tissuesnot invading the
pulpally involved tooth should be treated. Periodontal biologic width between restoration and the peri-
health, restorative considerations, and radiographic evi- odontal ligament (PDL), for example. Prior to any
dence of anatomic complexities associated with the tooth endodontic treatment, and after all present coronal
will have a major impact on any treatment decision. restorations and caries are removed, the remaining
tooth structure should be re-examined with a fiber-
Periodontal Disease optic light for fractures and perforations. At this time,
Periodontal stability is a basic requirement for any tooth teeth with vertical fractures or severe perforations are
being considered for endodontic therapy. This stability generally untreatable.
A B
Figure 6-9 Deep palatal groove anomaly leading to irreversible pulpitis and periodontal disease and tooth loss. A, Depth and severity of the
groove. B, Combined endodontal-periodontal lesion. (Courtesy of Dr. David S. August.)
It should also be noted that pulpless teeth are not RADIOGRAPHIC EXAMINATION
strengthened by the use of posts.58 Posts are for the In the sequence of examination, radiographic evalua-
retention of crown build-up. Retention of the crown tions should come last. In practical terms, one usually
and strength of the restoration depend on the design takes a look at the radiographs first and then proceeds
of the restoration, placing margins well onto solid with the other evaluation. Following the examination, in
tooth structure.
A B
Figure 6-10 A, Five mm pocket, first-degree mobility, and bleeding indicate moderate periodontitis associated with pulpless tooth.
Successful periodontal treatment may well be necessary to retain the endodontically treated tooth. A complete periodontal examination is
indicated. B, A pulpless tooth is periodontally involved as well. Recession (arrows) is undoubtedly related to crown preparation invading the
biologic width of the periodontal ligament attachment. (Courtesy of Dr. F. James Marshall.)
hindsight, radiographs can be better interpreted when teeth, their shadows may be shifted far to the mesial
the results of the previous examination are available. or the distal merely by shifting the horizontal angle
First, a few words about endodontic radiographs. of the cone of the x-ray machine to the mesial or dis-
The radiographic image is a shadow and has the elusive tal during separate exposures (Figure 6-15). On the
qualities of all shadows. First and foremost, it is a other hand, if the radiolucent area in the radiograph
two-dimensional representation of a three-dimension- is actually a lesion truly associated with the periapex
al object (Figure 6-11). Also, like any shadow, it may be of the involved tooth, its shadow will remain
too light or too dark, too short or too long. The central attached to the root end and will remain so in spite
beam must be carefully oriented to give detail where of a mesial or distal shift in separate films. For details
detail is required (Figure 6-12). This usually requires regarding the horizontal shift, the reader is referred
the central beam to be aimed directly through the peri- to chapter 9.
apex rather than a compromise position at the crest of
the alveolar process. Interpretation
In addition to central beam positioning, two or The finest radiologist will be severely handicapped in
more exposures are frequently necessary to check out securing valuable information from a film that has not
detail from more than one horizontal angle (Figure been properly placed, exposed, and processed.
6-13). This is especially true in the case of the normal Conversely, the finest film is of limited value if the
bony foramens. The mental foramen may be directly interpreter is inadequately trained.
superimposed over the apex of the mandibular pre- Neaverth and Goerig have emphasized the necessity
molars, for example (Figure 6-14). The nasopalatine of knowing the normal structures before interpreting
foramen also may be superimposed on the apex of the abnormal (personal communication, 1995). Using
the maxillary central incisors. Because these forami- radiographs of unusual clarity, they have delineated the
na are actually some distance from the apices of these anatomic structures of the posterior mandible and
Figure 6-11 Misleading radiograph related to lack of a third dimension. A, Failing root canal therapy in the maxillary central incisor
appears to be grossly overfilled. B, The extracted tooth seen in the radiograph proves that the case is not overfilled. Perforation was by huge
enlarging instruments used through restricted access cavity. (Courtesy of Dr. Eugene Meyer.) Reproduced with permission from Luebke RG,
Glick DH, Ingle JI. Oral Surg 1964;18:97.
Figure 6-13 Variations in horizontal angle improve radiographic interpretation. A, In this straight-on, labial-lingual pro-
jection, an internal resorption defect is seen. B, In a mesially directed projection, the extension of the resorptive defect to
the mesial-lingual is apparent.
A B
Figure 6-16 Above, Anatomic landmarks in a maxillary arch. H = maxillary sinus; I = floor of the maxillary sinus; J and K = bony septum
in the maxillary sinus; L = zygomatic process; M = maxillary tuberosity. Below, Anatomic landmarks in the mandibular arch. A = mandibu-
lar canal; B = mental foramen; C and G = cortical bone, border of the mandible; K = lamina dura; M = root canal filling. (Courtesy of Drs.
Albert C. Goerig and Elmer J. Neaverth.)
crest of the alveolar process should then be followed For example, if a large pulp chamber is seen in a sin-
from left to right, upper to lower, and all of the struc- gle adult tooth while other chambers are narrowing,
tures outside the alveolar process should be evaluated one should suspect a necrotic pulp, even though a peri-
as wellthe sinuses, floor of the nose, foramina, and so radicular lesion might not be apparent. In marked con-
on. In short, radiographic interpretation should be trast, Swedish dentists have reported dramatic narrow-
done in an organized habitual way so that nothing is ing of pulp chambers in patients with serious renal dis-
overlooked. ease, particularly those with transplanted kidneys who
Tracing the dark periodontal membrane space will are on high doses of corticosteroids.64
reveal the number, size, and shape of the roots and their Radiographic coronal evaluation includes depth of
juxtaposition. While observing the roots, one must look caries and restorations with respect to the pulp, as well
for periradicular lesions and root defects such as anom- as evidence of pulp cappings or pulpotomy, dens
alies, fractures, and external resorption. The number, invaginatus or dens evaginatus, and the size of the
curvature, size, and shape of all of the canals and cham- preparations under porcelain or resin jacket crowns.
bers should be noted along with internal resorption, Evaluation, however, comes down to a matter of per-
pulp stones, linear calcification, and open apices. sonal interpretation, as demonstrated by Goldman and
Figure 6-17 Brynolf s interpretation of the normal and resorbed lamina dura. Left, Radiographic appearance of a normal lamina dura
under magnification. Note the tit of bone (opposite A) thrusting toward the foramen (F). Center, Loss of lamina dura at the apex along
with apical inflammatory resorption from the necrotic canal (C). A = apical soft tissue; B = bone trabeculae; C = root canal; F = foramen;
L = PDL space; M = medullary space. Right, necropsy of specimen detailed in Center. Reproduced with permission from Brynolf I61 and
Brynolf I. Odontologisk Revy 1967;18 Suppl 11:27.
his colleagues.65,66 The radiographs of 253 cases, origi- could be detected and that loss of cancellous bone
nally examined by three faculty members at Tufts alone was not enough to be visible radiographically.72
University, were re-examined by them 6 to 8 months Bender has illustrated this dramatically with a radi-
later. These endodontists agreed with themselves from ograph of a molar tooth showing increased density of
72 to 88% of the time. Ten years later, however, the the bone at the periapex73 (Figure 6-18, A). Yet when
same group repeated essentially the same experiment the tooth was extracted, a huge granuloma was
with 79 other dentists and found that they not only dis- attached, which was not at all apparent in the film
agreed with each other over half the time but, worse (Figure 6-18, B).
yet, disagreed with themselves 22% of the time.67
Much the same was found by researchers in Israel63 and Root Anatomy
Greece.68 The radiographic examination provides essential infor-
Antrim found that holding the radiograph up to a mation relative to normal and abnormal root forma-
view box produced more consistent agreement among tion. Since mandibular incisors frequently have two
examiners than either projecting the radiograph or canals and, at times, two roots, adding an additional
using a magnifying glass.69 However, Weine has radiographic view from the mesial or distal can aid in
claimed that projecting the image produces the best detecting such anatomic variances.
interpretative result.70 One can expect anatomic variations in all tooth
One of the reasons for these discrepancies, of course, locations. Mandibular premolars and molars are no
deals with how one interprets bony lesions. Shoha et al. exception (Figure 6-19). By both radiographic and
were able to demonstrate the variables in this interpre- mechanical means (Figure 6-20), the number of canals
tation.71 They found that lesions were always larger and foramina should be determined before canal
than their radiographic image, especially in the enlargement is completed. Because of frequent varia-
mandibular molar region. Lesions in the premolar area tions, it is a good habit to examine radiographs with a
were only slightly larger than their radiographic image. magnifying glass so as not to miss an extra canal or
Lesions found by hindsight were often difficult to other variations.
detect initially because of their vague outline. In Maxillary first premolars with three roots or canals
Holland, it was found that cortical bone had to be are seen more clearly if the projected horizontal direc-
damaged by an osseous lesion before radiolucency tion of the central beam is slightly from the mesial
A B
Figure 6-18 Radiographic deception owing to the thickness of the cortical bony plates. A, Osteosclerosis distal to the second molar com-
pletely masks a huge bony lesion within spongy bone. B, Same tooth extracted with an enormous space-occupying granuloma (arrows), not
in the least suspected radiographically. Reproduced with permission from Bender IB.73
(Figure 6-21). The normal two roots or two canals of baffling case involved a maxillary lateral incisor with an
the maxillary first premolar also are easier to find if the unusual second root. In the post-treatment radiograph,
beam is directed from the mesial. A recent in vivo study a bony lesion could be seen to the distal (Figure 6-22,
showed that two canals are present in maxillary second A), but it was assumed that the lesion was related to
premolars 59% of the time, more than had been invagination from the cingulum. Because the lesion did
reported previously.7477 The mesial angulation tech- not heal, the tooth was extracted, and only then was the
nique is therefore beneficial in detecting the second extra root revealed (Figure 6-22, B and C). A radi-
canal in maxillary second premolars. In this case, the ograph of the contralateral incisor revealed what
lingual root always appears to the mesial on the film appeared to be a bilateral anomaly (Figure 6-22, D). As
(the SLOB ruleSame Lingual-Opposite Buccal).78 Slowey pointed out, whenever the outline of the root
Slowey has demonstrated how difficult it is to detect is unclear, has an unusual contour, or strays in any way
extra roots, let alone extra canals.79 One particularly from the expected radiographic appearance, one
Figure 6-19 A, Mesial root of first molar has not only two separate canals but an additional root as well (arrow). B, Two premolars with an
unusual root and canal formation. Fast break in canal radiodensity (arrows) indicates canal bifurcation. Both teeth have three and possi-
bly four canals, but the number of apical foramens can be determined only by instrument placement (see Figure 6-21). Reproduced with per-
mission from Slowey RR.79
Figure 6-20 Mechanical means of determining separate or common foramina for two canals. The instrument is placed to full depth in
either canal (1) and the instrument in the second canal (2) is prevented from going fully to place. Single foramina can then be confirmed by
raising the first instrument (3), allowing the second instrument to go fully to place (4). If turned, the instruments can be felt to grate against
each other. Reproduced with permission from Serene TP, Krasny RM, Ziegler PE, et al. Principles of preclinical endodontics. Dubuque (IA):
Kendall/Hunt Publishing Co.; 1974.
should suspect an additional root canal79 He quot- how to detect the undetected.79 One method is to fol-
ed Worth, who said, Look at the corners of the radi- low the image of the test file in the length-of-the tooth
ograph and the center will take care of itself.79 film, particularly in the coronal part of the root. If an
The mystery of extra canals within the normal num- extra dark line is apparent in the coronal third of the
ber of roots is more perplexing than the extra root root, running parallel to the instrument (Figure 6-23),
problem itself. Slowey has also given us some tips on one should suspect a second canal. This is especially
true in the mesiobuccal root of maxillary first molars,
where a fourth canal is found 51.5 to 69% of the time
in vitro75,76,8083 but only 18.6 to 33.3% in vivo.8284
Fourth canals frequently occur in the distal roots of
mandibular first molars as well84 (Figure 6-24).
Another diagnostic clue was pointed out by
Slowey.79 It could be called the fast break. When view-
ing a radiograph, if there is a sudden change in the
radiolucency within a canal, this change in density
probably signals the beginning of an additional canal
(Figure 6-25), a frequent occurrence in maxillary first
premolars. In mandibular canines (Figure 6-26, A),
such observations should be followed up by taking
additional radiographs from a different horizontal
angle (Figure 6-26, B) and possibly searching out the
extra canals with the length-of-tooth instrument films
(Figure 6-26, C).
Frequently, root formation results in severe curvature.
Figure 6-21 Three-rooted maxillary first premolar (arrow) and
second premolar are readily discerned in this radiograph. Clarity of When the curvature is to the mesial or distal, so fre-
root structure can be improved by aiming a central beam directly quently seen in the maxillary lateral incisors or occasion-
through the apical region. ally in premolars (Figure 6-27), there is little problem
A B
C D
Figure 6-22 A, Continuing lateral lesion (mesial) and acute abscess (arrow). The tooth is finally extracted.
B, Benchtop radiographic view reveals a second root and an unfilled canal (arrow), not seen in the original
films. C, Lingual view of second root and invagination from the cingulum. D, On the contralateral side, a
similar anomaly exists. Reproduced with permission from Slowey RR.79
A B
Figure 6-23 A, From viewing the initial film, one would not sus-
pect that there are two canals in the mesiobuccal root of the first
molar. B, An extra dark line alongside the exploring instrument
(arrow) signals the possibility of a second canal. C, Final film
showing two separate mesiobuccal canals (arrow) apparently aris-
ing from a common orifice. Reproduced with permission from
Slowey RR.79
A B
Figure 6-24 A, Two instruments in a single canal, but a wide, extra dark line (arrow) indicates an additional canal. B, Final filling proves
four canals. Reproduced with permission from Slowey RR.79
A B
Figure 6-25 A, Sudden change in radiographic density (arrow) signals probable canal bifurcation at that point. B, Change from right-angle
horizontal projection (A) to 20-degree projection from the distal clearly reveals two canals but a single foramen. Reproduced with permis-
sion from Slowey RR.79
A B
Figure 6-26 A, Fast break in radiograph of a
mandibular canine (arrow) indicates that a
search should be made for a second canal. B,
Varying horizontal projection reveals two
canals in hourglass-shaped root. C, Length-of-
tooth instruments in place reveal a single fora-
men. Reproduced with permission from
Slowey RR.79
Figure 6-27 Unusual mesial and bayonet curvature seen in three maxillary premolars and easy to detect.
in detecting the curvature. However, when the curvature itself and is literally x-rayed twice. In its extreme, a
is to the buccal or lingualin the same plane as the cen- peculiar target or bulls-eye appearance will show in
tral x-ray beamthe curvature is more difficult to detect the film (Figure 6-29).
(Figure 6-28). Careful examination may reveal increased In addition to normal variances in tooth form,
radiopacity at the root end as the root doubles back on such as curvatures and extra roots, anomalies that may
Figure 6-28 Double root canal curvature in a maxillary lateral incisor. A, Radiograph with instrument proves that the canal exits to distal.
B, Mesiodistal view of the same tooth shows that the canal also exits to the lingual. C, Apical photograph of the same tooth demonstrates an
instrument perforating the lingual far short of the apex. (Courtesy of Drs. Howard Clausen and John R. Grady.)
B C
Figure 6-29 Target or bulls-eye phenomena seen in roots that severely curve to the buccal or lingual, that is, in the direction of the cen-
tral beam. A, Central incisor with a dilacerated root under orthodontic realignment. B, Lateral head film in which the labially dilacerated
root (in A) is apparent (arrow). C, Resection and retrofilling of the dilacerated root seen in A and B. (A and B courtesy of Dr. Alfred T. Baum;
C courtesy of Dr. Dudley H. Glick.)
A B
Figure 6-31 A, Radiograph reveals 7 mm irregular radiolucency with a sclerotic border associated with an acute abscess. B, An extracted
fused supernumerary microdont that had a cyst attached. Reproduced with permission from Samuels DS. Oral Surg 1992;73:131.
Figure 6-33 Left (A) and right (B) bitewing radiographs reveal multiple pulp stones that have developed in the molar teeth of one patient.
Many stones are related to advanced carious lesions and large restorations. A, One stone (arrow) has also developed in an intact tooth.
From London, Lynch and Ahlberg reported bilateral External Resorption. Andreasen has stated that fol-
idiopathic internal resorption. The radiolucent areas lowing traumatic injuries there are three main types of
were cleanly defined, punched-out lesions. The pulp external root resorption: surface, inflammatory, and
was seen to disappear into the lesion.88 replacement resorption. Surface resorption is caused by
Herpes zoster was linked to resorption in other acute injury to the periodontal ligament and root sur-
cases. The varicella-zoster virus lies dormant for years face. Cell proliferation mediation removes the trauma-
in a nerve ganglion, from an earlier chickenpox tized structures. If injury is not repeated, healing takes
attack, and can suddenly reactivate to infect the pulp.89 place with new cementum and PDL. Inflammatory
resorption may occur from combined injury to the PDL
Conditions Outside the Tooth and cementum complicated by bacteria from the infect-
One of the most common occurrences seen radi- ed root canal, which, in turn, stimulate the osteoclasts.
ographically on the outside of the root of the tooth is Resorption usually ceases if the root canal is thoroughly
external resorption. dbrided and obturated unless stimulation has provoked
the third type of resorption, replacement resorption. In
this type, ankylosis between bone and tooth occurs with-
out the intervening PDL, and the constantly remodeling
bone slowly removes the tooth and replaces it with bone.
This is often seen in unsuccessful replant cases.90
Frank has delineated another type of external root
resorption that he terms extra-canal invasive resorp-
tion, totally different from regular external or internal
resorption.91 This phenomenon has interested clini-
cians and researchers over the last century and has been
variously called odontoclastoma,92 idiopathic external
resorption,93 peripheral cervical resorption,94 cervical
external resorption,95 peripheral inflammatory root
resorption,96,97 cervical resorption,98 and, more recently,
invasive cervical resorption.99
Frank et al. made the point that extra-canal inva-
Figure 6-34 Diagnostic radiograph of a first molar reveals early
sive is the more descriptive term100 (rather than
pulp death in the distal canal and calcification followed by necrosis
in the mesial canals leading to a periradicular lesion. Chisel-shaped external-internal, which Frank originally used)
resorption of the distal root typical of long-standing chronic because of the external origin of this resorptive defect,
inflammation. (Courtesy of Dr. Craig Malin.) before it invades the dentin (Figure 6-36), but, more
A B
Figure 6-35 A, Radiograph of lesion of internal resorption (arrow). Note sharp smooth margins. (Courtesy of Drs. A. H. Gartner, T. Mack,
R. Somerlott, and L. Walsh.) B, Drawing of internal resorption shows how the shadow of the pulp disappears into the huge lesion.
Reproduced with permission from a drawing modified from Lepp FH. Oral Surg 1969;27:185.
A B
Figure 6-36 A, Radiograph of lesion of extra-canal invasive resorption (arrow). Note the ragged margins of the lesion. (Courtesy of Drs.
A. H. Gartner, T. Mack, R. Somerlott, and L. Walsh.) B, Drawing of resorption shows how the shadow of pulp passes through the lesion
unaltered. Inset depicts external lesion perforating into and resorbing dentin. Reproduced with permission from a drawing modified from
Lepp LH. Oral Surg 1969;27:185.
important, that the destruction surrounds the root histopathologic appearance may be described as fibro-
canal without necessarily involving the pulp (Figure osseousbone-like depositions being evidentboth
6-37). This, of course, gives an entirely different radi- within the fibrovascular tissue and laid directly onto
ographic appearance than internal resorption. In resorbed dentin surfaces (Figure 6-40). Of clinical sig-
extra-canal invasive resorption, the pulp appears to nificance is the deeply infiltrating channels that often
pass through the lesion (Figure 6-38), whereas the interconnect with the periodontal ligament. Effective
pulp disappears in the internal resorptive lesion (see treatment can be achieved only if all ramifications are
Figure 6-35). inactivated or removed (see chapter 12).
The histopathologic characteristics of this insidious Jaacob examined 18 of these cases and determined
and often aggressive form of invasive tooth resorption that the pulp spaces were separated from the resorptive
are of interest and significance to clinicians. Although areas by a resistant dentin shell.101 Quite possibly, this
the invading tissue is derived from ectomesenchymal phenomenon of not invading the pulp relates to the
precursor cells within the periodontal ligament, it dif- character of the dentin surrounding the pulp. Clastic
fers both in structure and behavior from the periodon- cells generally attack well-calcified structures such as
tal ligament. In early lesions, the invading tissue is bone, dentin, and cementum. The pulp, however, is
fibrovascular (Figure 6-39), which accounts for the surrounded by uncalcified predentinuncalcified
pinkish appearance that may be evident near the gingi- material not readily amenable to cellular clastic action.
val margin of the affected teeth.99 Later, as resorption In addition, there is evidence for an anti-invasive factor
extends more deeply into radicular tooth structure, the in tooth dentin.102
Figure 6-39 Histologic appearance of an incisor tooth with exten- Figure 6-40 Histologic appearance of an extensive invasive cervi-
sive invasive cervical resorption. An intact layer of dentin and pre- cal resorption with radicular extensions. Masses of ectopic calcific
dentin on the pulpal aspect (*) separates the pulp from the resorb- tissue are evident both within the fibrovascular tissue occupying the
ing tissue. The resorption cavity is filled with a mass of fibrovascu- resorption cavity and on resorbed dentin surfaces. In addition,
lar tissue with active mononucleated and multinucleated clastic communicating channels can be seen connecting with the peri-
cells lining resorption lacunae (arrows). (Original magnification odontal ligament (large arrows). Other channels can be seen with-
40.) (Courtesy of Dr. John McNamaara; reproduced with permis- in the inferior aspect of the radicular dentin (small arrows).
sion from Heithersay GS.99) (Original magnification 30.) Reproduced with permission from
Heithersay GS.99
Although most extra-canal invasive root resorption (see Figure 6-38, C).91 If the lesion is visible radi-
occurs at the immediate subgingival level ographically, but not apparent visually, it may be
supraosseous, if you will (see Figure 6-38, A)Frank probed for with a curved explorer.
et al. described an additional intraosseous variation The intraosseous variety of extra-canal invasive
that is difficult to locate radiographically since it is resorption (see Figure 6-38, B) is characterized radi-
not accompanied by periodontal breakdown. 100 ographically as having an irregular moth-eaten appear-
There may, however, be an open lesion just at or ance within the tooththe more advanced, the more
beneath the gingival sulcus (Figure 6-41, A). In addi- radiolucent (see Figure 6-41, B). Again, close examina-
tion, the resorption may extend into the coronal tooth tion will show the outline and integrity of the canal
structure, and a pink tooth may result (Figure 6-42), that appears to pass through the lesion unaltered
much the same as with coronal internal resorption. (Figure 6-43). The pulp usually tests vital and has been
This may be more apt to happen with what Frank asymptomatic. The radiographic appearance of these
described as a crestal variety of invasive resorption lesions varies. In early lesions, a small radiolucency may
Figure 6-41 A, Extra-canal invasive resorption, supraosseous, of the central and lateral incisors. The integrity of the root canals remains
intact. B, Extra-canal invasive resorption, intraosseous, of the maxillary lateral incisor. Arrow marks the labial site of origin. (Courtesy of Dr.
Alfred L. Frank.)
A B
Figure 6-43 Extra-canal invasive resorption, supraosseous. A, Lesion (arrow) superimposed over the canal. B, Same tooth, radiographed
from the mesial; the lesion shifts (arrow) within the tooth. Pulp tests are vital. (Courtesy of Dr. Alfred L. Frank.)
1 3
2 4
Figure 6-44 Heithersays clinical classification of invasive cervical resorption: Class l: A small invasive resorptive lesion near the cervical
area with shallow penetration into the dentin. Class 2: A well-defined invasive resorptive lesion that has penetrated close to the coronal pulp
chamber but shows little or no extension into the radicular dentin. Class 3: A deeper invasion of dentin by resorbing tissue, not only involv-
ing the coronal dentin but also extending at least to the coronal third of the root. Class 4: A large invasive resorptive process that has extend-
ed beyond the coronal third of the root canal. Reproduced with permission from Heithersay GS.99
B C
Figure 6-50 Chronic apical periodontitis involving five mandibular anterior teeth. Pulp death from impact trauma. Well-circumscribed
lesions and pear-shaped configuration periradicular to the canine are typical of chronic apical periodontitis. These may be confused with an
apical cyst. A bifurcated canal (black arrow, left) is also apparent. A sudden change in radiolucency in the canal (open arrow) denotes point
of separation of canals.
A B
Figure 6-52 A, Diffuse radiolucent appearance (arrow) of an asymptomatic apical abscess (AAA) (with stoma) is here contrasted with an
asymptomatic apical periodontitis (AAP) associated with a lateral incisor (no stoma). B, Asymptomatic apical abscess with drainage through
buccal stoma following chronic infection of an apical cyst. Huge diffuse radiolucency is typical of AAA. The root of the tooth is displaced later-
ally by pressure from the cyst.
A B
Figure 6-53 A, Diffuse radiographic appearance (right arrow) of an asymptomatic apical abscess may be overlooked owing to radiopacity
of the heavy cortical bone. Also noted are condensing osteitis and external root resorption from chronic pulpitis (left arrow), as well as an
anomalous third root of the third molar. B, Extraoral stoma (neck) of 8 years duration, draining from the chronic apical abscess seen in A.
Immediately following root canal therapy, the discharge ceased, and the stoma healed to a navel of scar tissue.
Figure 6-54 Movement of teeth is pathognomonic of a cyst. A, Root separation beginning from modest cyst develop-
ment. Typical circumscribed radiopaque perimeter may be confused with asymptomatic apical periodontitis. B, Pulpless
lateral incisor with infected apical cyst. The canine has been particularly displaced. C, Lateral cyst (arrow) not involved
with a pulpless tooth. D, Same case, 14 months later. Teeth remain vital. Biopsy, lateral periodontal cysts. C and D repro-
duced with permission from Degering CI. Oral Surg 1971;32:498.
The confirmatory post-treatment film follows lesions or those with potential post-treatment prob-
completion of the root canal filling. It should be made lems. If any abnormal or unusual findings are noted, it
before a coronal restoration is placed because some may be necessary to re-treat, either surgically or non-
correction in the canal filling may have to be made. surgically, or if changes are uncertain, further re-evalu-
Ideally, the final film for the record, and the duplicate ation may be indicated. Patients, however, may not
film to be returned if a referring dentist is involved, consider post-treatment evaluation to be important,
should be taken without the rubber dam clamp particularly if they are asymptomatic. Riley surveyed
(Figure 6-63, C). 159 diplomates of the American Board of Endodontics,
Confirmatory progress films are also important dur- who reported that fewer than half of their patients
ing surgery. Searching for root tips, lost filling material, returned on recall.115
location of root apexes during trephination or apicoec- Re-treatment Radiography. Before initiating re-
tomythese are only a few of the uses made of confir- treatment, particularly a referred patient, the dentist
matory radiographs. must always have a fresh film. Films sent with the
Post-Treatment Evaluation Radiograph. Historically, patient by the referring dentist may be outdated and
post-treatment evaluations have been a part of clinical may also have been taken prior to a procedure such as
endodontic practice. This radiograph allows an oppor- access preparation. A new film may supply surprising
tunity to evaluate changes taking place periradicularly information about the tooth, perforations, broken
as a result of root canal therapy (Figure 6-63, D). A instruments, failure to obturate, ineffective surgery,
1-year interval is a realistic time frame for most and a number of conditions well below the standard of
endodontic cases such as those with initial apical care (Figure 6-64).
Figure 6-60 Importance of multiple roentgenographic exposures. A, Lateral incisor appears to be the principal-
ly involved tooth in this direct buccolingual projection. B, Projection through the central incisor shows that it is
involved in the lesion as well. The lateral incisor is vital and the central incisor is nonvital, pulp death having devel-
oped from trauma (arrow). C, Following therapy, new bone develops throughout the area, and both teeth reat-
tach. (Courtesy of Dr. Pierre R. Dow.)
A B
C D
Figure 6-61 Chronologic development of an internal resorptive defect that has become external as
well. The patient is an adolescent female with bruxism (see chapter 4 and Figure 424).
A, Mandibular incisors apparently involved with asymptomatic apical periodontitis. The pulps of
both teeth are vital. B, The referring dentist mistakenly opened into vital pulp of the right central
incisor. Detecting his error, he placed a temporary filling and dismissed the patient. C, Six months
later, internal resorption from the stimulated pulp has perforated the root, and external resorption
has also begun. D, Total pulpectomy, root canal therapy, and amalgam repair of the resorptive lesion
save the incisor. The left central incisor remains vital. Alleviation of trauma from bruxism will allow
healing.
Figure 6-63 Importance of initial and confirmatory radiographs. A, The initial film alerts the dentist to confusing canal anatomy and a signif-
icant periradicular and lateral root lesion. B, Confirmatory length of the tooth radiograph reveals the presence of a C-shaped canal.
C, Immediate postoperative confirmatory film shows a complicated root canal system obturated by vertical compaction of warm gutta-percha.
Obtura II was used for back-filling. D, Confirmatory 1-year follow-up film shows the degree of healing. (Courtesy of Dr. Michael J. Scianamblo.)
A B
C D
Figure 6-64 A, Root perforation (arrow) and associated periodontal lesion are revealed by radiography. Condensing osteitis and external
root resorption are related to chronic pulpitis, the initial complaint. B, C, and D, Treatment errors and failures revealed by radiographs. B,
Fissure bur broken in the canal; C, totally ineffective canal obliteration. An inadequate coronal access cavity is smaller than the canal and the
apex to be dbrided and obliterated; D, complete butchery and total failure in attempted multiple apicoectomies. The canals are inade-
quately filled, and amputated root tips have been left in place.
a pulpless maxillary central incisor that was draining alveolar canal. Paresthesia may also follow surgery in
extraorally through a stoma as far as the angle of the ala the region of the lower premolars.
nasi116 (Figure 6-65). A similar situation, draining Sixty-one cases of facial numbness were reviewed by
directly into the nostril from a periradicular lesion of a researchers at the Mayo Clinic,118 who found that 83%
central incisor, was reported from Israel.117 of the cases had a definite cause, including 48% in
Sinus tracts related to cracked teeth are most per- which the numbness was of dental origin. Thrush and
plexing and often can be diagnosed only by the laying Small reported seven cases of facial numbness, only one
of a surgical flap. In one particular case, the fracture case of which was dentaltypical mandibular numb-
was not discernible in the initial radiograph, but fol- ness following a most profound local anesthesia and
lowing obturation of the root canal, the horizontal molar extraction.119 The remaining cases of numbness
fracture became readily apparent (Figure 6-66). were caused by carcinoma of the nasopharynx, tumor
invasion of the gasserian ganglion, adenocarcinoma of
Numbness the brainstem, and cerebrovascular accident. All of
A symptom occasionally associated with endodontic these patients exhibited numbness of the jaws, lips,
cases is numbness in either the area containing the tongue, or palate. They summarized their report by
tooth or paresthesia of a distant part, such as the lip. saying, The most important task is to exclude neopla-
When numbness occurs, one should also be concerned sia. They recommended basal views of the skull and
with trigeminal neuropathiestumors or cysts that examination of the nasopharynx.119
involve the innervation.
Numbness can also be related to large periradicular Persistent Discomfort
lesions encroaching on the mandibular canal (Figure 6- After completion of treatment, either nonsurgical or
67, A). In this case, after root canal therapy, the numb- surgical, some patients continue to have symptoms.
ness subsided, and within 14 months the lesion had Others develop discomfort some time later. A patient in
healed and normal sensation had returned (Figure 6- the latter category was examined radiographically
67, B). Numbness associated with an acute alveolar months after root canal therapy and placement of a
abscess is often noted, but in such cases, the diagnosis bridge abutment. The discomfort was midtooth, and
should be quite obvious. Paresthesia may follow gross the radiograph revealed a bony lesion in that area along
overfilling in the mandible, which invades the inferior with external root resorption and a poorly obturated
Figure 6-66 A, Preoperative film reveals no fracture line associated with chronic fistula. B, Cement is extruded (arrow) into
the fracture line. (Courtesy of Dr. Cyril Gaum.)
Figure 6-67 A, Extensive periradicular lesion encroaching on the mandibular canal (arrow). Numbness results. B, Successful endodontic result,
14 months later. Numbness disappeared as healing advanced. Note the two distal canals and lateral canal as well. (Courtesy of Dr. Cyril Gaum.)
midcanal (Figure 6-68, A). After re-treatment through bizarre symptom of continued sensitivity to cold.120
the crown, the discomfort subsided (Figure 6-68, B). After careful examination ruled out the possibility of
Failing root canal therapy appears to be one of the pulpitis in an adjacent tooth, Glick concluded that an
causes of post-treatment discomfort. additional canal must be present in the treated tooth,
Glick reported a number of cases of persistent dis- one that was missed during treatment. Reopening the
comfort following root canal filling along with the pulp chamber and searching for the extra canal was not
Figure 6-68 A, Persistent discomfort after endodontic treatment and bridge placement. The lesion (arrow), midroot with some resorption,
indicates a patent accessory canal. B, Re-treatment obturates the accessory lateral canal, healing occurs, and discomfort is alleviated.
(Courtesy of Dr. Joel L. Dunsky.)
productive. In desperation, Glick sealed formocresol in was being forced through this tiny hole into the entire
the chamber, which immediately and permanently side of the face and neck (see Figure 6-70).
eliminated the pain. Although not advocating this as a In a recent study, the phenomenon of barodontalgia
routine procedure, Glick has found it effective on a (aka aerodontologia) was also reported during simulat-
number of occasions. ed high-altitude flights and in actual flights.
In another report (Figure 6-69), cotton and Cavit Endodontically treated teeth or teeth with necrotic
(3M/Espe; St. Paul, Minn.) were sealed in a post-space
preparation of a distal canal of a mandibular molar,
resulting in continuous pain. When the post space was
not used for the intended post and core, the space was
refilled with gutta-percha and sealer. The cause of dis-
comfort immediately became apparent when sealer was
forced out of a minute fracture line.
In a most perplexing and life-threatening situation
reported by Verunac,121 a young submariner consistent-
ly developed massive facial emphysema each time the
submarine dived. The swelling would become pro-
nounced after the submarine was deeply submerged for
15 hours (Figure 6-70). Within 4 or 5 days after surfac-
ing, the swelling would disappear. Navy physicians had
given him antibiotics to no avail and had recommended
his discharge from the service. Examination by a dentist
revealed a lingual cusp fractured away from a maxillary Figure 6-69 Cement extruded through an undisclosed hairline
first premolar, exposing the lingual canal that was patent fracture (arrow) reveals the source of persistent discomfort.
through the foramen. The air under submerged pressure (Courtesy of Dr. Cyril Gaum.)
pulps did not respond painfully in pressure chamber porcelain jacket crown (Figure 6-72, A), diagnosed as a
simulation. Only teeth with inflamed vital pulps react- fracture with pulp involvement. The crown was
ed to pressure change.122 removed, and what appeared to be a fracture turned
Another cause of persistent discomfort reported ear- out to be a high chamfer crown preparation. This was
lier in this text relates to root-filled teeth wherein the verified with a second radiograph (Figure 6-72, B). The
apex perforates a fenestration of the buccal bone. A sim- pulp was necrotic.
ilar report from Paris noted that the discomfort was
relieved when the root end was exposed surgically and Idiopathic Tooth Resorption
the portion of the root extending through the fenestra- It is difficult at times to determine the cause (or caus-
tion was trimmed back to within the bony housing.123 es) for cases of root resorption. One such case involved
the roots of a mandibular molar bridge abutment,
Cracked Tooth Syndrome where resorption began shortly after root canal therapy
Infraction of tooth structure (cracked tooth syn- (Figure 6-73, A). Within 212 years, the roots had com-
drome) accounts for many perplexing diagnostic prob- pletely resorbed away (Figure 6-73, B to D). One might
lems. A typical situation is that of a patient who expe- speculate that this resorption could have been related
rienced intermittent episodes of acute pain radiating to the patients breast cancer. It has been postulated
over the entire side of the face. The periradicular radi- that a parathyroid-like hormone is secreted by tumor
ograph revealed a periradicular lesion, and vitality test- cells, and there is a high incidence of hypercalcemia in
ing proved the pulp to be nonvital. Before endodontic patients with breast cancer.
therapy was started, a bitewing radiograph was taken, Breast cancer could not have been an etiologic factor
revealing a vertical fracture into the pulp (Figure 6-71). in a similar case reported by Poliak (personal communi-
It is interesting that the crack could not be seen in the cation, 1975). His patient was a middle-aged male
periradicular film but did show in the bitewing. Crown motion picture producer who developed an unexplained
fractures, if in a buccolingual direction, may be more resorption 5 years following therapy of an endodontical-
easily detected by bitewing radiographs. ly treated mandibular second molar. Within 2 years, the
entire root structure had essentially resorbed away. From
Bizarre Radiographic Appearances England, Pankhurst et al. reported a number of teeth in
Radiographs have many limitations, one of which is the same patient with idiopathic resorption.124
that many conditions can produce similar appearances
on x-ray films. Just such a case is illustrated in a film of Treatment Failures
a maxillary incisor. The tooth was exquisitely tender to The examination of the treatment failures is important
percussion and was mobile. In the radiograph, a hori- because if the cause of failure can be determined and
zontal radiolucency appeared above the margin of the corrected, the failure may be reversed.
Figure 6-72 A, Radiolucent line (arrow) is suspected of being a fracture under the jacket crown. B, The jacket
crown is removed, and the fracture becomes a high chamfer preparation. (Courtesy of Dr. Cyril Gaum.)
Figure 6-73 Unexplained root resorption of bridge abutment in a patient with breast cancer. A, Initial film. B,
One month later. C, Seven months later. D, Two and a half years later. (Courtesy of Dr. Cyril Gaum.)
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Chapter 7
DIFFERENTIAL DIAGNOSIS AND
TREATMENT OF DENTAL PAIN
John I. Ingle and Dudley H. Glick
For there was never yet a philosopher who could endure the By all odds, the most frequently seen pain patient
toothache patiently. will be experiencing acute, true intraoral pain,
William Shakespeare, toothache and its sequelae being the most common.
Much Ado About Nothing, Act V, Scene 1 Pain accompanying intraoral lesions and infections is
the next most commonly seen. After that, the field thins
Orofacial pain is a major public health problem. This somewhat, with top priority going to the acute pains of
fact was recently emphasized by a report from the US everyday general, endodontic, and oral surgery practice.
National Center for Health Statistics (NCHS). Less commonly seen, but a good deal more baffling,
are the chronic pains found in and around the mouth,
Although their figures and estimates apply only to the
a number of them referred there from faraway sites.
United States, they may generally be extrapolated
These are the craniofacial pains to be discussed in detail
worldwide.
in Chapter 8. Because these two types of oral and peri-
The NCHS interviewed 45,711 households in the
oral pain are so different in diagnosis and manage-
US civilian population. This was the 1989 National
ment, they will be dealt with separately, even though
Health Interview Survey (NHIS). Using the statistics
there is often a confusing overlap.
developed from this survey, the National Institute of
The first premise in diagnosis is to play the percent-
Dental Research reported in 1993 that about 39 mil-
ages, thinking first of the most commonly occurring.
lion people or about 22% of the U.S. population 18
As the old saying goes, If you hear hoofbeats, think of
years of age or older are estimated to have experienced
horses, not zebras. If an obvious diagnosis is not imme-
at least one of five types of orofacial pain more than diately apparent, a good diagnostician begins with the
once during the past six months.1 most frequent cause of this type of pain, not some
This alarming cohort of 39 million can be further obscure, seldom seen syndrome. Systematically working
broken down into 22 million toothaches (12.2%), 15 down through the pain roster, from most common to
million oral sores (8.4%), 9.5 million jaw joint pains least common, a logical diagnosis is finally arrived at.
(1.4%), and 1.3 million burning mouth pains (0.7%). A well-trained dentist may render many services that
The total adds up to more than 39 million because some gain him a deep personal satisfaction. Foremost among
respondents suffered from more than one type of orofa- these are the diagnosis and relief of excruciating or
cial pain.1 Of the 45,711 households interviewed, 9,072 long-lasting pain. These are the occasions patients
people reported orofacial pain. These figures, extrapolat- remember most vividly: the night you came back at
ed nationwide, may actually be too low because the midnight and relieved my terrible toothache, or
Armed Forces, institutions (prisons, etc), and children you diagnosed the constant pain I had for 3 years,
under age 18 were not included in the statistics. Doctor, and after everyone else had given up.
The shocking revelation that 22 million people in Solving these problems is rarely rewarding financial-
the United States suffer from a toothache within a ly, but they are the few moments we as a profession
6-month period is an overall prevalence rate of 12,261 enjoy that set us apart from the lay public. These prob-
persons per 100,000 population. The prevalence for lems also try ones patience and ingenuity; only the
African Americans (14,584) and Hispanics (14,226) skilled are successful in diagnosing and managing the
was even higher.1 really difficult cases.
Figure 7-1 Pain produced by air blast. A, Air evaporates dentinal Figure 7-2 The effect of cold stimulus on the pulp. A, Cold is
fluid, causing rapid outflow (arrows) owing to capillary pressure applied to the tooth, causing a contraction of fluid in tubule. B,
from the pulps vessels. B, Odontoblast and accompanying nerve Pulp capillary pressure forces replacement fluid into the tubule
fiber aspirated into tubule, stretching nerve and causing pain. C, along with the odontoblast and afferent nerve. Stretching of nerve
Prolonged air blast caused a protein plug to form in the tubule, pre- (arrow) produces intense pain. Redrawn with permission from
venting outward flow. Redrawn with permission from Brnnstrm Brnnstrm M. Dentin and pulp in restorative dentistry. Nacka
M. Dentin and pulp in restorative dentistry. Nacka (Sweden): (Sweden): Dental Therapeutics AB; 1981. p. 17.
Dental Therapeutics AB; 1981. p. 15.
The same phenomenon is produced by the dental ued even after the temperature had returned to the ini-
drill, the frictional heat and surface pressure displacing tial level for a few minutes, and (3) a pulsating type of
the tubule fluid and causing pain. Scraping or chiseling response in which the discharge of the fiber was syn-
the dentin produces similar pressure and pain. chronized with the heartbeat.8
Pulp pain produced by cold is a similar phenome- Brnnstrm added to the understanding of the
non. When cold is applied, the fluid in the tubules con- pumping excitation by dentinal fluid when he point-
tracts, thus redirecting the fluid volume. Fluid contrac- ed out, Fluids have a considerably greater coefficient
tion within the tubules again produces fluid outflow of expansion than solidsa sudden rise in temperature
owing to the normal pulp pressure, and the nerves are of 20C at the outer one-third of the closed tubule
once again stretched into the tubules along with the
odontoblasts (Figure 7-2).5 Beveridge measured a fall
in intrapulp pressure when cold was applied to a tooth6
(Figure 7-3). Researchers in Israel found this to be an
interstitial pressure fall, whereas the arterial trans-
mural pressure rose.7
Hyperreactive pulpalgia owing to the application of
heat is more easily explained. Again, Beveridge easily
demonstrated a true increase in intrapulp pressure
when heat was applied to the tooth (Figure 7-4). An
increase of pressure within the pulp serves to excite the
sensory pulp nerves.6
Three different types of response to heat have also
been recorded from pulp nerve fibers: (1) a transient Figure 7-3 Effect of intrapulp pressure by application of cold
ethyl chloride spray to anesthetized mandibular premolar in a
type of response when pulp nerve fiber was excited by 13-year-old boy. Within 8 seconds, intrapulp pressure had dropped
heat over 43C (the response ceased as soon as the tem- from 30 mm Hg to nearly zero. After the irritant was removed, pres-
perature fell below the firing points), (2) a long-lasting sure returned to initial baseline within 1 minute. Reproduced with
type of response that started at over 45C and contin- permission from Beveridge EE, and Brown AC.14
Hyperemia
All minor pulp sensations were once thought to be
associated with hyperemia, an increased blood flow in
the pulp. The investigations of Beveridge and Brown
demonstrated, however, that an increase in intrapulp
tissue pressure is produced only when heat is applied to
the tooth, not when cold is applied.6,14 The increased
pressure against the sensory nerve endings in the pulp
might well produce the sensation associated with
hyperemia. Quite possibly, this will explain why the
pain appears to be of a different intensity and character Figure 7-5 Effect on a partially anesthetized pulp from pain elicit-
with applications of cold or heat, the cold producing a ed by cavity preparation on the maxillary premolar of an
11-year-old girl. Intrapulp pressure dropped about 10 mm Hg
sharp hypersensitivity response and the heat producing within 25 seconds, during which the patient experienced pain.
true transient hyperemia and a dull pain. When drilling ceased, intrapulp pressure climbed slowly to a level
This difference in the character of the painful slightly higher than the original baseline. Reproduced with permis-
response between cold and hot might well be explained sion from Beveridge EE, and Brown AC.14
by the difference in the nerve fibers supplying the pulp:
The pulp contains both myelinated A nerve fibers nation may not elicit an unusual reaction. In this case,
and unmyelinated C nerve fibers. The former [A] the entire tooth must be surrounded by cold for the
are fast-conducting and have a low response pulp to react. This particular condition is best checked
threshold, whereas the latter [C] are slow-con- by isolating the teeth adjacent to the suspected tooth
ducting with a higher activation threshold. behind a heavy rubber dam and then playing a stream
Activation of the A fiberswill cause a sharp of ice water onto the tooth being examined.
localized response, whereas activation of C fibers If the tooth has had a recent restoration, it usually
will cause a dull, poorly localized response.10 responds to applications of ice, carbon dioxide ice, or
Fluori-Methane (Gebauer Chemical Co., Cleveland,
Cold stimulates the fast-conducting A fibers, pro- Ohio) or ethyl chloride sprayed on a large cotton pellet.
ducing the sharp, localized pain. Continued heat appli- Cervical dentin exposed by scratching with an explorer
cation, on the other hand, will more likely stimulate the may also elicit a pain response.
slower-conducting C fibers, deeper in the pulp, with a Hyperreactive teeth are also said to be more sensitive
resulting dull pain of longer duration, the pain also to the pulp tester; that is, they require lower levels of
experienced with early pulpitis.10 Trowbridge con- electrical stimulation to produce a response.10
curred in reviewing the action of the A and C fibers and Electrical stimulation is different from other types of
pointed out that approximately 25% of the dentinal stimuli in that it does not cause movement of the fluid
tubules contain nerve fibers.11 within the dentinal tubules.10 The sensation derived
The converse of pain from pressure also appears to from electrical stimulation has been described as a
be true. Beveridge and Brown have shown the effect of prepain sensationtingling, hot, sharp or warm;
pain on intrapulp pressure.14 Paradoxically, pulp pain rarely is it described as painful.10
causes first a fall and then, when removed, a rise in Some of the fast-conducting A fibers are initially
intrapulp tissue pressure (Figure 7-5): This again rais- stimulated by electricity and are described by Nahri as
es the question of the role of neural control in the reg- A beta fibers with conduction velocities well beyond
ulation of intrapulp pressure.14 It was also discovered the A delta fibers stimulated by tubule fluid movement.
that intrapulp pressure decreased when the patient fell At higher levels of electrical stimulation, the slower C
asleep and increased when she awakened. fibers kick in so that the summation of A and C fibers
produces the painful response associated with higher
Examination electrical stimulation.15
Determining which tooth is hyperreactive by examina-
tion is not always as simple a step as it might seem. A Treatment
patient may complain of the symptoms of hypersensi- Grossman has stated, The best treatment for hyper-
tivity on taking cold water into the mouth. On the emia lies in its prevention.16 This is sound advice.
other hand, ice on the suspected tooth during exami- Application of the new resin adhesives or placement of
an insulating base under metallic restorations will Agents that have been tried and found wanting are cal-
materially reduce most hypersensitivity. Moreover, this cium hydroxide, formalin, and silver nitrate.
sensation usually diminishes gradually as irritation Tubule-sealing agents that have proved successful are
dentin builds to protect the dental pulp. potassium oxalate, strontium chloride, sodium and
There is, however, another source of continuing stannous fluoride, and the resins, including the new
irritation often overlookedmicroleakage.17 Virtually adhesives. Another approach, using potassium nitrate,
every restoration placedamalgam, resin, cemented blocks sensory nerve activity at the pulpal end of the
restorationswill share some degree of microleakage tubules by altering the excitability of the nerves.
around and under the filling. The bacteria collected Potassium oxalate as a desensitizing agent was
here will again produce acidic irritants that could developed by Greenhill and Pashley.21 It is sold com-
affect the pulp through the dentinal fluid. The result- mercially as PROTECT (John O. Butler Co., Chicago,
ing degree of sensitivity will, in great measure, depend Ill.). Applying potassium oxalate to the dentin surface,
on the presence or absence of a smear layer that which, in turn, produces calcium oxalate crystals of
obstructs the tubuli.17 Removal of the smear layer different particle sizes within the dentinal tubules, is a
(which is very fragile to acids such as those found in means of obstructing the tubules apertures (Figure 7-
soda drinks and fruit juices) and its replacement with 6). Calcium oxalate is poorly soluble and is formed
one of the new resin bonding agents will materially when the potassium oxalate contacts the calcium ions
overcome the problem of microleakage. These adhe- in the dentinal fluid.18 A single-dose applicator per-
sives have been shown to be a substitute for an insu- mits pinpoint delivery, to the sensitive area, of
lating cement base. monopotassium-monohydrogen oxalate. Although the
Since a true hyperreactive pulp is not a pathologic degree and duration of relief will vary from patient to
condition, it may continue to be sensitive for years, act- patient, the effectiveness of a single application by the
ing as a distress signal, warning against insult to a partic- dentist can last up to 6 months.
ular tooth. The patient learns to avoid the involved tooth One rather crude study was less than enthusiastic
and often becomes a unilateral masticator in the process. about oxalate dentin desensitization after 3 months
The pulp seems well able to accept constant insult, and using a monopotassium-monohydrogen oxalate
the statement that long-standing hyperemia eventually agent,22 whereas a more sophisticated American and
terminates in pulp inflammation and death is patently two Japanese reports conveyed a good impression of
false. Apparently, something more than hypersensitivity the oxalate solution for densensitization.2325
or hyperemia must be present to lead to necrosis. One Strontium chloride is contained in two toothpastes
would suspect inflammation and/or infection. on the market, Sensodyne (Block Drug Co., Jersey City,
Recent interest in eliminating dentinal hypersensi- N.J.) and Thermadent (Mentholatum Co., Buffalo,
tivity has stimulated the revival or development of a N.Y.). Strontium combines with phosphate in the
number of modalitiesphysiologic, chemical, or dentinal fluid and exchanging for calcium in the
mechanical in nature. Physiologic methods are rem- hydroxyapatite of the dentinal tubule walls may pro-
ineralization of the dentinal tubulii from the calcium duce strontium phosphate crystals and dentinal tubules
phosphate-carbohydrate-protein complex in the saliva closure.18 Goodman believes that the strontium ion
and/or from the formation of irritation dentin from alters neural transmission, which may account for the
the pulp. Both of these techniques can take place natu- immediate improvement in relieving sensitivity.26
rally over long periods of time, but artificially stimulat- Strontium may also stimulate the formation of irrita-
ing salivary flow and/or pulp activity are too time con- tion dentin, and it has been reported as well to bind to
suming and painful to be practical.18 the matrix of the tubule, thus reducing its radius.27
For chemical/mechanical obstruction, the ideal The fluorides, sodium and stannous, have been used
desensitizing agent should be non-irritating to the pulp; as desensitizing agents longer than any of the other min-
be relatively painless on application; be easily applied; be eral salts. Initially, sodium fluoride was used in paste
rapid in action; have long-term or permanent effective- form (33%) and burnished into the sensitive areas.
ness; and produce no staining.19 Krauser pointed out Repeated applications were necessary. Neither stannous
the obverse, that an agent may be effective (1) in one nor sodium fluoride anticaries rinses or toothpastes,
individual but not in another, (2) on one tooth but not however, are particularly effective desensitizers.
on others, and (3) against one stimuli but not others.20 Goodman has stated that, Fluoride is thought to
Various agents have been used in attempts to seal work by reaction between the fluoride ion and ionized
the peripheral ends of tubules in sensitive dentin.18 calcium in the tubular fluid to form an insoluble calci-
A B
um fluoride precipitate.26 It may also stimulate the for- reduction in hypersensitivity.28 According to a report
mation of irritation dentin. from India,29 a comparative evaluation of the desensi-
Stannous fluoride with carboxylmethylcelluose in a tizing effects of the topical application of 33.3% sodi-
glycerine gel was found to be significantly more effec- um fluoride paste, of iontophoresis with a 1% solution
tive than a placebo gel in reducing hypersensitivity,18 of sodium fluoride, and of iontophoresis with the
and an acidulated sodium fluoride solution decreased patients own saliva was made. Iontophoresis with
conduction in the tubuli by 24.5%. If sodium fluoride sodium fluoride produced immediate relief after one
was applied by iontophoresis, hydraulic conduction in application, whereas topical application required two
the dentinal tubules was decreased by 33%.21 to three applications. The authors concluded that ion-
Fluoride iontophoresis has been recognized for tophoresis with 1% sodium fluoride is the method of
years as a consistently successful treatment for dentinal choice for the treatment of hypersensitive dentin, as it
hypersensitivity. Gangerosa is credited with populariz- meets all the requirements of an ideal desensitizing
ing this treatment when he introduced the Electro agent except permanency of effect, which requires fur-
Applicator. The Desensitron (Parkell Products, ther investigation (Table 7-1).29
Farmingdale, N.Y.) has also proved effective. Gangerosa reported very similar results as well as
To use these battery-powered devices, the patient recommending the iontophoretic application of the
holds the positive electrode in his hand and the dentist, fluoride in a tray to desensitize a number of teeth.3033
using the negative electrode, applies a 2% solution of Carlo and colleagues reported 100% desensitization
sodium fluoride to the sensitive areas of the teeth. after two iontophoretic fluoride treatments 73.9% of
Using this technique, Simmons reported 94 to 99% the time.34 Brough et al., on the other hand, found one
Table 7-1 Comparison of Desensitizing Method29 In another study, a light-curing dentin bonding
agent, Scotchbond (3-M Co., St. Paul, Minn.), was
Group
painted onto sensitive areas of exposed dentin and
I* II II light-cured for 20 seconds.27 After one treatment, all
Degree of Relief (%) (%) (%) sensitivity was eliminated in 89% of the extremely sen-
sitive surfaces and in 97% of the moderately sensitive
Good 33.33 55.55
surfaces. After 6 months, 85 percent of these teeth were
Moderate 52.94 44.45 35.13
[still] without sensitivity and only 15 percent exhibited
None 13.73 64.87
any sensitivity at all.27 In contrast, a control group
*Treatment by topical application using a 33.3% solution of sodium treated with a sodium fluoride/strontium chloride
fluoride. solution received virtually no relief.27 More recently,
Treatment by ionophoresis using a 1% solution of sodium fluoride.
Treatment by ionophoresis with patients own saliva.
Amalgambond (Parkell Products, Farmingdale, N.Y.), a
4-META bonding agent, was tested: Initially all teeth
treated had an immediate response of no sensitivity. At
6 months, 18 of 19 treated teeth showed decreased sen-
application of 2% sodium fluoride by iontophoresis to sitivity, 15 of those showing no sensitivity. All control
be no more effective to cold response than a similar teeth remained sensitive.39 A similar study, in which
application with distilled water or 2% sodium fluoride several coats of a dentin primer (NPG-GMA, BPDM)
without iontophoresis.35 were applied to root sensitive teeth, achieved similar six
Potassium nitrate as a desensitizing agent was devel- months resultsall patients symptomless except one
oped by Hodash, who reported the use of saturated who was slightly sensitive to ice.40
solutions and pastes to be used for home care that The authors of this study are very positive that the
contain up to 5% potassium nitrate.36 These pastes are success of resin adhesive therapy depends on careful
sold over the counter as Promise and Sensodyne Fresh preparation of the root surface and application of the
Mint (Block Drug Co., Jersey City, N.J.) and Denquel resin before curing. If or when the resin wears away and
(Vicks Oral Health Group, Wilton, Conn.). sensitivity returns, additional application should elim-
Hodash reported that Relief of hypersensitivity inate the discomfort once again. Many of the manufac-
was notable and rapid in most instances, and that turers of dental adhesives are making extended claims
Potassium nitrate is also an extremely safe chemi- for the effectiveness of their product to reduce hyper-
cal.36 Goodman has shown some impressive clinical sensitivity, and this appears justified.
results using dentifrices containing potassium In conclusion, there are a number of alternative
nitrate.26 He suggested that desensitization may occur modalities that will desensitize hypersensitive dentin.
either by the oxidizing nature of potassium nitrate or It boils down to what works best in the dentists
by crystallization, which blocks the tubules, or both.26 and/or the patients hands. One must remember that
Pashley, on the other hand, believes that potassium the placebo effect is always present and that at least
nitrate does not block the tubules but instead reduces 30% of the time, anything that is done will achieve a
the sensitivity of the mechanoreceptor nerves to the result, for example, the relief achieved over 3 months
movement of dentinal fluid in the tubuli, which nor- using only water.35
mally would produce painful stimuli. Although the It should also be remembered that molars are usu-
fluid still shifts, according to Pashley, the nerves ally less sensitive than cuspids or premolars, which are,
would not fire because they would be rendered unex- in turn, usually less sensitive than incisorsolder teeth
citable.37 Goodman also believes that the potassium are less sensitive than younger teeth.18 Also, dental
ion depolarizes the nerve fiber membranein which plaque elimination should be the first priority before
few or no action potentials can be evoked.26 Patients any treatment is undertaken.
should be encouraged to use the desensitizing denti-
frices frequently. Acute Pulpalgia
Composite resins and bonding adhesives have also True pulpalgia begins with the development of pulp
been used very successfully to reduce or eliminate denti- inflammation or pulpitis. Beveridge and Brown have
nal hypersensitivity. Early on, isobutyl cyanoacrylate was shown that an increased intrapulp tissue pressure is
found to be effective by blocking the dentinal tubules. possible.14 It may be postulated that this pressure
Bahram stated that Cyanoacrylate should be repeated might well be the stimulus that is applied to the senso-
after 6 weeks.38 ry nerves of the pulp and leads to severe toothache.
Incipient Acute Pulpalgia. The mild discomfort fortable sensation but an extended pain. Moreover, the
experienced as the anesthetic wears off following cavi- pain does not necessarily resolve when the irritant is
ty preparation is a good example of incipient pulpal- removed, but the tooth may go on aching for minutes
gia. The patient may be vaguely aware that the tooth or hours, or days for that matter.
feels different, as though it has been worked on, but Excitation. Moderate pulpalgia may start sponta-
the sensation disappears by the next morning. neously from such a simple act as lying down. This
Stanley and Swerdlow have shown extravascular alone accounts for the seeming prevalence of toothache
migration of inflammatory cells following even modest at night. Some patients report that the pulp aches each
irritation by a controlled and cooled cavity prepara- evening, when they are tired. Others say that leaning
tion.41 It is most fortunate that, from the incipient over to tie a shoe or going up or down stairsany act
stage, pulpitis is reversible, and the discomfort vanish- that raises the cephalic blood pressurewill start the
es. One would suspect that incipient pulpalgia is so pain. The list of inciting irritants would not be com-
mild that the pulpitis it predicts is often ignored by the plete without mentioning hot food or drink, sucking
patient until it is too late. This could well be true of the on the cavity, and biting food into the cavity. Most pain
initial sensation developing with a new carious lesion, of moderate pulpalgia, however, is started by eating,
the slight ache in response to cold or sweets (see usually something cold.
Figures 62 and 63). Hahn and his associates have reported a correlation
Excitation. Incipient acute pulpalgia must be stim- between thermal sensitivity in irreversible pulpitis
ulated by an irritant such as cavity preparation, cold, cases and the microorganisms present in deep carious
sugar, or traumatic occlusion. lesions. Using anaerobic testing methods, they found
Examination. If the pulpalgia follows cavity prepa- that Fusobacterium nucleatum and Actinomyces viscosus
ration, the involved tooth is obvious. If dental caries is were associated with sensitivity and prolonged pain
the noxious stimulus, the cavity is found by an explor- induced by cold. Other bacteria produced heat-sensi-
er and radiographs. The lesion may be quite small, just tive responses.42
into the dentin. The patient can usually tell which A warm water rinse does not usually relieve the pain,
quadrant is involved and may even point out the and cold water makes it worse. The patient may find,
involved tooth. Cold is the best stimulus to initiate however, that two or three aspirin or acetaminophen
incipient acute pulpalgia. The pulp tester is of ques- tablets bring relief. He may continue to take analgesics
tionable value in these cases. for days, while wishfully thinking that the pulp will
When traumatic occlusion is causing the pain, the recover. Too many dentists also practice this same game
diagnosis becomes more difficult (see Traumatic of self-deception.
Occlusion, below). Examination. Attempting to determine which
Treatment. Removal of the carious lesion followed tooth is involved with moderate acute pulpalgia is
by calcium hydroxide application and a sedative often a difficult experience. The patient may report
cement for a few days may be all that is required to after days of discomfort, and by this time the pain,
arrest incipient acute pulpalgia. Watchful waiting fol- though still present, may be widespread and vague. The
lowing cavity preparation should not extend to pro- patient believes he can pinpoint the exact tooth, but
crastination, leading to moderate or advanced acute then he becomes confused. The typical statement, the
pulpalgia. Corticosteroids placed in the cavity follow- tooth stopped aching as soon as I entered the office, is
ing preparation or used on the dentin surface prior to commonly heard. No amount of irritation will start it
cementation of extensive restorations have proved again. If the patient is on heavy analgesics or mild nar-
effective for reducing postoperative pain (HR Stanley, cotics, it is best to postpone examination until respons-
personal communication, 1984). es will not be clouded by drugs.
Moderate Acute Pulpalgia. The pain of moderate If the pain has been constant for some time, all of
acute pulpalgia is a true toothache, but one the patient the pulps on the affected side seem to ache, and, fre-
can usually tolerate. Many patients report for dental quently, two or three give approximately the same
attention after hours, or sometimes days, of discomfort response to the pulp tester or thermal testing. This is
from the developing pulpitis. The pain is frequently where intuition comes into play. The examiner gets a
described as a nagging or a boring pain, which may feeling about a particular tooth. It might respond a
at first be localized but finally becomes diffuse or bit sooner to the pulp tester, or it may ache just a bit
referred to another area. The pain differs from that of a longer after cold is applied. The restoration seen in the
hyperreactive pulp in that it is not just a short, uncom- radiograph may be just a little deeper. All too frequent-
ly, in this day of full coverage, a number of teeth may tooth and the other the referred tooth. If an anesthet-
be restored with full crowns, a situation that manifest- ic is injected into the suspected arch, and the hunch
ly compounds the problem. was correct, the pain should stop in both teeth. If the
If the pain is only vague when the patient is first pain does not stop, the offending tooth is in the oppo-
seen, the dentist should attempt, by careful question- site arch. Again, by means of the anesthetic test, aching
ing, to obtain a general idea of the area of the pain. mandibular premolars may be differentiated from
Usually, the patient can tell which side is involved and molars by the use of a mental injection that will anes-
frequently whether pain is in the maxilla or the thetize from the second premolar toward the midline.
mandible. This may not be absolute, however, for the A zygomatic injection in the maxillary arch for the
pain may be referred from one arch to the other. The maxillary molars, or a careful slow infiltration for the
patient may remember where the pain started initially, maxillary premolars injected well forward toward the
hours or days before. Examination of the suspected canine, may differentiate between these confusingly
area may immediately reveal the involved tooth, made similar pains. Nor should one forget the interligamen-
obvious by a large carious lesion or huge restoration. tary injection (see chapter 9). Injecting down through
Then again, nothing unusual may be present. the periodontal ligament allows each individual tooth,
Radiographs may give an immediate clue in the even each individual root, to be anesthetized. Although
form of a huge interproximal cavity or a restoration this analgesia may not be profound enough for pulpec-
impinging on the pulp chamber. If nothing is learned tomy, it may prove adequate to stop pulpalgia from
from radiographic examination, the electric pulp tester referring. The anesthetic test is a last resort and should
is then employed, but generally without great success. be used after all other means have been exhausted.
A tooth involved in moderate acute pulpalgia is In diagnosing moderate acute pulpalgia, above all,
hypersensitive and will respond sooner, or lower, on the the examiner must think, must be shrewd, and must not
scale of the pulp tester. Then again, all of the teeth in panic. If in doubt, hesitate! Often one more day may
the area may be hypersensitive and respond in the same make a difference. The patient should be warned to
way to pulp testing so that no definite conclusions may return to the office without having taken any analgesics.
be drawn from this test. This leaves the thermal test as Treatment. The treatment for moderate pulpalgia
the final arbiter since percussion and palpation rarely is quite simple: pulpectomy and endodontic therapy if
reveal any response, although the tooth may be slightly the tooth can and should be saved or extraction if the
sensitive to percussion. tooth should be sacrificed. If endodontic therapy is
The first thermal evaluation to use is the cold test indicated, it may be completed in one appointment.
because the pulp is more likely to respond to this stim- Hodosh and colleagues, who reported favorably on
ulus. The tooth under the greatest suspicion should be the use of potassium nitrate as a desensitizing
tested first. The examiner should block the adjacent agent,36,43 also used the chemical mixed with carboxy-
teeth with his fingers, being careful that melting ice does late cement as a pulp-capping medium in teeth with
not run onto these teeth. The immediate response to pulpitis. In a preliminary report, they noted that all of
cold may be quite sudden, violent, and lasting. On the the teeth became asymptomatic immediately but that 2
other hand, the initial pain may go away immediately of 86 failed.43
when the cold is removed. This is the time to stop! Do Glick used Formocresol to treat pulps that continue
not test any more teeth for about 5 minutes. The reason to ache after root canal therapy has been completed.
for this is quite obvious: The pain in the tested tooth His supposition is that vital, inflamed tissue still exists
that stops aching may rebound within a few minutes, in a canal that is impossible to locate. The tooth may
and if the dentist has proceeded to test other teeth, nei- even respond to thermal and electric testing. The
ther he nor the patient will be able to differentiate the Formocresol embalms the microscopic remainder of
aching tooth. If the pulp starts to ache, however, reap- the pulp, and the pain is alleviated.44 In the same vein,
plying the cold should increase and prolong the pain. a US Army dentist reported two endodontically treated
Infrequently, heat is the stimulus that starts the teeth that still ached when heat was applied. After
symptoms. Sometimes, however, nothing will start the re-entry, a careful search revealed additional untreated
ache, and the patient must be dismissed and asked to canals. Total pulpectomy and root canal filling com-
return when the tooth is again painful. pletely eliminated the postoperative pain.45
Occasionally, the search is narrowed down to a max- In the Orient, toothache has long been alleviated
illary and a mandibular tooth, both prime suspects with acupuncture. A favorite site to place the acupunc-
because both are aching. One molar is the problem ture needle is the Hoku pointmidway in the web of
tissue between the thumb and index finger on either Examination. The examination for advanced
hand. Temporary relief of pain is achieved after a few acute pulpalgia, in comparison to that for moderate
minutes of needling this point. The respected pain pulpalgia, is relatively simple, even if the tooth is not
center group at McGill University has reported similar aching when the patient presents himself. The
results by massaging the Hoku point for about 5 min- involved tooth always has a closed pulp chamber, as
utes with an ice cube wrapped in a handkerchief. Ice, revealed by the radiograph. Otherwise, the tremen-
an analgesic, helps overload the circuits, quickly clos- dous intrapulp pressure could not develop. In addi-
ing the pain gate, according to the researchers.46 This tion, the radiograph may reveal a thickened periodon-
simple method of pain control might well be recom- tal membrane space at the apex as the inflammation
mended to a patient unable to appear immediately at spreads out of the pulp.
the dental office. The history is self-incriminating. The symptoms are
Advanced Acute Pulpalgia. There is never any violent! The involved tooth usually can be pointed out
question about the patient suffering the pain of by the patient and is sometimes tender to percussion as
advanced acute pulpalgia. He is experiencing one of the well. These teeth are said to be less sensitive to the pulp
most excruciating acute pains known to humanity, tester (requiring a higher reading), but the perform-
comparable to otic abscess, renal colic, and childbirth. ance of this test is merely gilding the lily. Heat is the
If every dentist personally experienced the pain of merciless offender. Hahn reported that cavities filled
advanced acute pulpalgia, he would be a more sympa- with black pigmented Bacteroides, Streptococcus
thetic practitioner for the experience. mutans, and total anaerobic colony counts were posi-
This patient is in exquisite agony and sometimes tively related to the heat sensitivity in irreversible pul-
becomes hysterical from the pain. The patient often is pitis cases.42
crying and virtually unmanageable. One patient, who Because the inflamed pulp reacts so violently to heat,
had to drive 40 miles to a dentist, reported that he the most decisive test is the heat test, although one
could stand the pain no longer, so he stopped the car, must have a cold water syringe in the other hand, ready
took out a pair of pliers, and pulled his own tooth. to give immediate relief. As soon as the hot gutta-per-
Patients have confessed contemplating suicide to cha touches the involved tooth, the patient develops
escape the pain. what Sicher has called the subgluteal vacuum; he sud-
The relief for this pain is embarrassingly simple: denly rises up in the chair as if stabbed. Cold water is
cold water, preferably iced. Cold water rinsed over instantly applied, and the pain subsides.
the tooth is all that is usually needed to arrest the The thermal test is conclusive! When the patient is
pain temporarily. The patient might discover this fact again comfortable, however, the adjacent teeth should
while taking an analgesic and, in so doing, receive also be tested to ascertain that no more than one tooth
immediate relief. He then reports to the dentist with is involved or that the suspected tooth gives the most
a thermos or jar of ice water in hand, only stopping violent reaction. The patient should be assured that the
to sip as the pain gradually returns. Frequently, he involved tooth will not again be warmed.
times the periods of relief much as the expectant Local anesthesia gives blessed relief, and the dentist
mother times her labor pains. The relief often lasts 30 has, from that moment, made a friend for life. The
to 45 seconds. friendship will be more lasting if the tooth is saved by
When a patient telephones reporting a toothache, endodontic therapy rather than extracted.
especially late at night, the dentist should always Treatment. The treatment for advanced pulpalgia
inquire, Have you tried rinsing cold water on the is the same as for moderate pulpalgia: pulpectomy and
tooth? If the answer is negative, request that the endodontic therapy for the salvageable tooth and
patient do so and return to the telephone to report extraction for the hopeless one.
results. If the cold gives relief, the compassionate pro- Complete anesthesia of an inflamed pulp may be
fessional meets the patient as soon as possible to pro- difficult even though all outward signs would indicate
vide permanent relief. If cold aggravates the pain, the the conduction or infiltration injection to be success-
patient has moderate pulpalgia, which might well ful. In this case, an intrapulp injection of lidocaine or
become advanced pulpalgia by morning. The patient pressure anesthesia with lidocaine or an interligamen-
with advanced pulpalgia would have to continue rins- tary injection may be necessary.
ing with cold water throughout the night, and, even Following pulpectomy, the pulpless tooth should be
then, the cold may no longer give relief. Thus, a tired relieved of occlusal contact by grinding. Endodontic
and frazzled patient becomes a hysterical one. therapy should be completed at a later appointment.
Chronic Pulpalgia cyst, severe persistent pain (Class IV) occurs with both
The discomfort from chronic pulpalgia is best ascent and descent.
described as a grumble, a term commonly used by Rauch pointed out that even though the highest
patients who withstand the mild pain for weeks, incidence factor is less than 2 percent, because of the
months, or years. Often the pain can easily be kept vast number of people who fly, barodontalgia must be
under control with one or two analgesic tablets, two or considered in the differential diagnosis of oral pain.48
three times daily. Frequently, the patient seeks relief Examination. Determining which tooth is involved
only when the pulp begins to ache every night. with chronic pulpalgia is often ridiculously simple and,
The pain from chronic pulpalgia is quite diffuse, and on other occasions, most difficult. Frequently, a large
the patient may have difficulty locating the source of carious lesion is present, or an amalgam restoration is
annoyance. Patients frequently say that they have a fractured at the isthmus. Another common offender is
vague pain in my lower jaw. Chronic pulpalgia is like- recurrent caries under a restoration, usually an inlay.
ly to cause referred pain, which is also mild. Other These are the lesions that are painful when compressed
patients may appear with beginning acute apical by food packed into the cavity.
abscess and confess to knowing that something was The leathery dentin covering these lesions may be
wrong with the tooth for months. Other patients removed with a spoon excavator, often without anes-
comment on the bad taste or odor constantly noted. thesia and with no great discomfort. The pulp lies
Excitation. The pulp involved in chronic pulpalgia revealed, covered with a gray scum of surface necrosis.
is not affected by cold but may ache slightly on contact Biopsy would show degeneration of the remainder of
with hot liquids. The most common report is that the the pulp, accounting for the lack of severe pain.
tooth is sore to bite on. If meat or a bread crust, for The chronic pulpalgia that is the most difficult to
example, is crushed into the cavity, the pain lasts until diagnose lies under a full crown because it is impossi-
the irritant is dislodged. The patient may report that ble to pulp test electrically, or under a three-quarter
the tooth begins to hurt late in the day, when Im crown, where recurrent caries is not revealed by radi-
tired, or, more frequently, when I lie down. ographs. In these cases, carbon dioxide ice should be
Barodontalgia. One patient confessed to discom- used as the stimulant.
fort each Monday morning and Friday evening. These The pulp tester and the radiograph are the best tools
were the times each week when he crossed a 4,000-foot for locating the tooth involved with chronic pulpalgia,
mountain pass in his travel across Washington state. which will sometimes respond as necrotic to electric
Here the slight difference in barometric pressure was testingthat is to say, it will take the maximum dis-
enough to excite the pain response. The same may be charge from the tester. In any case, a high reading on
true during an airplane flight. (Planes are actually pres- the rheostat should be expected. England and col-
surized at 5,000 feet, not sea level.) leagues demonstrated intact nerve fibers, with some
Kollman tested 11,617 personnel of the German variations from normal, in pulp specimens with irre-
Luftwaffe who participated in simulated high-altitude versible pulpitis.49 In the necrotic pulp, dissolution of
flights up to 43,000 feet: Only 30 (0.26%) complained the fibers was apparent.
of toothache (barodontalgia). Chronic pulpitis was the The radiograph often reveals interproximal or root
principal culprit, followed by maxillary sinusitis.47 caries, or recurrent caries under a restoration. In
Rauch classified barodontalgia (formerly called chronic pulpalgia, the so-called thickened periodon-
aerodontalgia) according to the chief complaint.48 If tal membrane also may be present, indicating that the
the patient has pulpitis, he will have pain on ascent inflammatory process is not confined completely to the
sharp momentary pain (Class I) in the case of acute pulp. These cases may also demonstrate condensing
pulpitis, and dull throbbing pain (Class II) in the case osteitis of the cancellous bone at the apices.
of chronic pulpitis. These pains are caused by the extra- Interestingly, this osteosclerosis disappears after suc-
oral decompression of the ambient pressure in the cessful endodontic therapy (see Figure 5-9).
plane, which, in turn, allows for a compensating The apices of the involved roots also show external
increase of pressure within the pulp chamber and root resorption, although this condition is more prevalent
canal. Descent (compression of the ambient pressure) following pulp necrosis and complete periradicular
brings relief in the pulpitic tooth. If the pulp is necrot- involvement (see Figure 649).
ic, the reverse is true, a dull throbbing pain (Class III) Thermal tests are of little value in a positive sense in
on descent (compression) and asymptomatic on ascent diagnosing chronic pulpalgia, although, in some cases,
(decompression). In a case of periradicular abscess or slight pain may be experienced in response to extreme
heat. This is in accord with the patients history of no Necrotic Pulp. There are no true symptoms of
response to iced drinks but an occasional response to complete pulp necrosis for the simple reason that the
hot coffee. pulp, with its sensory nerves, is totally destroyed. Often,
Percussion has a good deal to offer in many of these however, only partial necrosis has occurred, and the
cases. Often the patient is vaguely aware that something patient has the same vague, comparatively mild dis-
feels different about the involved tooth when it is per- comfort described for chronic pulpalgia.
cussed. Palpation is virtually useless. However, having The examiner also must bear in mind that the pulp
the patient bite on an applicator stick sometimes in one or two canals in multirooted teeth may be
reveals soreness of a particular tooth. necrotic, and the pulp in a second or third canal may be
Chronic pulpalgia has the aggravating habit of refer- vital and quite probably involved in acute or chronic
ring its vague pains throughout the region. The patient pulpitis. The results of examination in these cases are
may insist that a mandibular molar is aching, whereas most bizarre because each level of pulp vitality is rep-
examination reveals that a maxillary molar is the resented by a confused response.
offender. Often anesthetizing the involved tooth is the Examination. A routine radiographic survey or
only convincing proof to the patient that he is wrong. coronal discoloration may present the first indication
Patients have reported with aching of a maxillary molar that something is amiss in the case of the tooth with a
when the maxillary lateral incisor has been found to be necrotic pulp. On questioning, the patient may recall
the offender. If the tooth suspected by the patient an accident of years ago or a bout of pulpalgia long
appears normal to all examination and testing, the since forgotten.
examiner should be suspicious of chronic pulpalgia in Many cases of pulp necrosis are discovered because
another tooth on the same side. The mandibular molar of the discoloration of the crown. This applies primari-
involved in chronic pulpalgia is not as apt to refer pain ly to the anterior teeth and ranges from a vague discol-
to the ear as it is in acute pulpalgia.
oration, visible only to the trained eye, to frank discol-
Treatment. The treatment for chronic pulpalgia is
oration of the darkened tooth. A discernible difference
quite basic: pulp extirpation and endodontic therapy if
may sometimes be demonstrated by transillumination
the tooth is to be saved and extraction otherwise.
with a fiber optic.
Anesthesia is no problem.
The radiograph may be helpful if a periradicular
Hyperplastic Pulpitis. The exposed tissue of a
lesion exists because its presence usually indicates asso-
hyperplastic pulp is practically free of symptoms
ciated pulp death. Radiographically, the tooth with the
unless stimulated directly.
Excitation. The discomfort of a hyperplastic necrotic pulp may exhibit only slight periradicular
pulp is quite simple. It erupts out of its open bed of change; in other words, a radiolucency is usually found
caries for all to see. Differential diagnosis is con- by hindsight rather than foresight. Then again, a sizable
cerned with only one problem, namely that of dis- periradicular bony lesion may accompany the necrotic
cerning whether the polyp is pulp or gingival in ori- pulp. No changes in the canal are noted radiographi-
gin because both are covered by epithelium (see cally to indicate necrosis.
Figures 4-72 and 4-73). One of the first lessons to be learned, however, is
The pulp polyp may be lifted away from the walls never to trust a radiograph alone in diagnosing pulp
with a spoon excavator and the pedicle of its origin necrosis. A snap judgment of the periradicular radiolu-
thus revealed. It is remarkably painless to handle and cency that exists with periradicular osteofibrosis associ-
may even be excised with a sharp spoon excavator with ated with perfectly normal, vital pulps will lead to error
no great discomfort. if the examiner depends on radiograph evidence alone.
Treatment. Frequently, the teeth involved in hyper- It is imperative always to pulp-test the tooth.
plastic pulpitis are so badly decayed that restoration is The electric pulp tester, therefore, is the instrument
virtually impossible. Hence, extraction is usually indi- of choice for determining pulp necrosis. With complete
cated. On the other hand, if the tooth can be restored, necrosis, no response will be given at any level on the
pulpectomy and endodontic therapy are recommended tester. With partial necrosis, a vague response that can
prior to restoration. Glick reported limited success with easily be tolerated may be elicited at the top of the scale.
pulpotomy in these cases, done originally as an experi- The tooth with a necrotic pulp may also be slightly
ment on three cases with good bleeding (personal com- painful to percussion.
munication, 1964). He was surprised to see periradicu- Treatment. There is no treatment for pulp necrosis
lar repair take place. per se because the necrotic pulp has long since been
destroyed. If the tooth can be saved, endodontic thera- hyperocclusion often responds much like the tooth
py is indicated. with mild pulpalgia. First, the pulp is usually hypersen-
Internal Resorption. Internal resorption is an sitive, reacting primarily to cold. In addition, the pain
insidious process when the afflicted pulp is completely may be vague, reminiscent of chronic pulpalgia.
free of symptoms. On the other hand, this condition The patient may complain of being bothered by
has been known to mimic moderate acute pulpalgia in pulp discomfort on awakening in the morning or pos-
pain intensity. The usual case, however, closely resem- sibly of being awakened by the discomfort. The story of
bles the chronic pulpalgia syndrome, that is, mild pain pain at the end of a rather trying day is also character-
at the tolerable level. When confined to the crown, istic. Pathognomonically, the patient reports relief after
enough tooth structure may be destroyed for the pulp only one aspirin. Moreover, he usually says that the
to show through the enamelhence the synonym for tooth is not painful on mastication; at least this is not
internal resorption, pink tooth. his chief complaint.
Excitation. Symptoms of internal resorption Paradoxically, even a well-treated pulpless tooth being
depend primarily on whether the process has broken traumatized by bruxism presents the vague symptoms of
through the external tooth surface. If the pulp destroys pseudopulpalgia. It, of course, does not respond to ther-
enough tooth structure to finally erupt into the oral mal stimuli but still feels like a mild toothache.
cavity, it responds much as the hyperplastic pulp, Examination. From the patients history usually
painful only to pressures of mastication. comes the clue to diagnosing the pain from trauma.
Because the pulp is undergoing dystrophy localized History of toothache on awakening is an unusual
to a single area, it is not as likely to be excited by the symptom and should direct ones thinking toward
drinking of hot or cold fluids. The pulp that erodes bruxism at night. The discussion of a tense daily situa-
through the root surface may give vague symptoms, tion is another clue. The vagueness of the pain is most
primarily with mastication, but the patient usually important because one expects to be dealing with
remembers these symptoms in retrospect after the con- chronic pulpalgia, and yet the thermal and pulp tester
dition is pointed out on the radiograph. response is often like that of a normal or hyperreactive
Examination. Two methods of examination reveal pulp. The fact that a low dosage of a mild analgesic can
the case of internal resorption: visual examination if control the pain is pathognomonic.
the crown is involved and radiographic examination If one suspects pain from trauma, one should look
for the crown and root. Thermal tests and the electric for facets of wear on the tooth. Articulating paper may
pulp tester may provide confirming, yet only partially be helpful; however, the point of contact may not be
reliable, evidence. readily apparent. One young patient shifted her
The case of internal resorption that is truly difficult to mandible forward during sleep and ground the distal of
diagnose is the one of coronal involvement often hiding the mandibular second molar against the mesial of the
behind the full or three-quarter crown and thus not maxillary first molar, a protrusive shift of a full cen-
revealed in the radiograph. The patient complains of timeter. It was difficult to believe that the two well-worn
vague symptoms and referred pain, but the response of facets would match, and yet, when the youngster was
the involved pulp to the testing procedures may be sim- teased into protruding her mandible to this extent,
ilar to that of the other teeth. Percussion may be of slight causing contact between the two surfaces, her eyes light-
value. In these cases, an intuitive hunch is needed. If one ed in delight, and she began compulsive bruxism.
is fortunate, the correct tooth, when tested, may exhibit It should be remembered that the mandible also may
slight variances from the other teeth in the area. On the be retruded in sleep, causing facets distal to masticato-
basis of these minor variances, the suspected tooth is ry facets to be involved. Examination for these annoy-
chosen; however, the presence of internal resorption is ing contacts should be carried out with the patient
not confirmed until the coronal pulp is entered. supine in the dental chair.
Treatment. Pulpectomy is the only treatment for Too many dentists examine the median occlusion
internal resorption. As long as the pulp remains, it is position (centric) and the lateral excursion of function
most likely to continue its destructive process. If the (working bite) and completely neglect to examine for
tooth can be saved by endodontic restoration, the nonfunctional (balancing bite) traumatic contacts. So
defect can best be obturated by thermoplasticized and
compacted gutta-percha.
Traumatic Occlusion. A tooth traumatized by Contraction or stretch of muscles (as in yawning) is often pleasur-
often the nonfunctional contact is the patients com- The most frequent complaint is that of a tooth
pulsive position. Some patients even bring diagrams to painful to bite on, with an occasional mild ache. One
the office to describe the point of interference, demon- case was diagnosed over the telephone on the basis of a
strating an abnormal and exaggerated oral awareness. report of these classic symptoms by the harassed refer-
Peculiarly enough, the involved tooth or teeth are ring dentist. The patient confirmed the diagnosis by
frequently not sensitive to percussion but are sensitive reporting the same day with the buccal cusp of a max-
to mastication. Biting or chewing on a narrow cotton illary premolar in hand.
roll or Burlew disk will sometimes elicit discomfort. Excitation. The discomfort of the split tooth is
The radiograph may show no periradicular changes elicited by biting on the tooth or contacting cold fluids.
or may exhibit a widened periodontal space and apical If the pulp is involved in fracture, any exciting agent for
external root resorption (see Figure 646). pulpalgia will bring on discomfort.
Treatment. Treatment for these cases obviously Examination. First, one thinks of carefully examin-
involves relieving the point of occlusal trauma by judi- ing the tooth, dried and under good light, to find the
cious grinding to reshape the involved tooth and its crack in the enamel. Usually, the search goes unreward-
opponent. Actually, the tooth should be completely dis- ed because the examiner sees no cracks at all or finds
occluded to give the inflamed tissue a chance to recover. similar enamel crazing in every tooth.
Many times, the dentist is unsure of his diagnosis, The pulp tester customarily gives a normal reading
especially in cases that closely resemble or actually are unless the pulp is involved. Thermal tests may be valu-
pulpitis. The pulp should be given the benefit of the able if a cold or hot stream is played on the tooth or hot
doubt, particularly if a fully restored crown is involved or cold fluids are rinsed against the possible culprit.
and complete testing is difficult. If symptoms and signs Hot gutta-percha or a stick of ice, on the other hand, is
are vague, the case should first be handled as a problem usually valueless.
of traumatic occlusion, especially if there is some evi- Percussion alone, surprisingly enough, is usually not
dence that this might be true. If, after careful adjust- helpful, yet biting on an applicator stick or cotton roll
ments, the pulp does not respond with almost immedi- may give the spreading action needed to elicit pain.
ate relief, the possibility of pulpitis should be reconsid- The crown may also be painted with tincture of
ered, but only after all of the excursions of the iodine, which is washed off after 2 minutes. The crack
mandible and the patients history are rechecked. often appears as a dark line (see Figure 412).
Sometimes the patient reports relief as soon as the A piece of Burlew rubber disk can be used to stress a
occlusion corrections are completed, even before leav- possibly fractured tooth. Held in a locking pliers, it can
ing the chair. be shifted around to different positions on the occlusal
Incomplete Fracture or Split Tooth. The tooth surface while the patient is asked to bite on it. An even
that is split or cracked but not yet fractured presents more definitive device is the Tooth Slooth (Laguna
some of the most bizarre symptoms encountered in Niguel, California, USA), a triangular plastic tip on a
practice. These symptoms range from those of a con- handle (Figure 7-7). With this device, it can be deter-
stant, unexplained hypersensitive pulp to constant, mined quite accurately which cusp is splitting away.
unexplained toothache. The radiograph records an obvious split only if it is
The tooth may be uncomfortable only occasionally in correct alignment to the central rays (Figure 7-8). It
during mastication, and at that time the pain may be will completely fail to reveal the almost microscopic
one quick, unbearable stab. This is when the crack in split, which elicits the really bizarre syndrome.
the dentin suddenly spreads as the cusp separates from Treatment. If an incomplete fracture is suspected
the remainder of the tooth. The pulp may only be but the pulp is not involved, the crown should be pre-
hypersensitive, possibly for years. In one case,
follow-up continued for 8 years, and the pulp hyper-
sensitivity immediately ceased when the buccal cusp
fractured away.
Many of the cases involve noncarious, unrestored
teeth; hence it is hard to believe that anything could be
wrong with the tooth. If the split has extended through Figure 7-7 The Tooth Slooth, a fracture detector. The concave
area at the peak of the pyramid is placed on the tip of the suspect-
the pulp, bacterial invasion occurs, and true pulpitis ed cusp. The patient bites down on the plastic device, and the den-
results. These cases are comparatively easy to diagnose tist watches for changes in facial expression or verbal reaction.
because of the obvious symptoms. Several cusps should be tested.
Figure 7-8 Radiographs are usually useless in diagnosing undetected fracture. A, The point of fracture (arrow) cannot be seen in a clinical
radiograph. B, After the tooth is extracted and radiographed in a mesial-distal direction, fracture into the pulp (arrow) becomes apparent.
Also note lateral canals. (Courtesy of Dr. Dudley H. Glick.)
pared for a full crown, which should then be cemented In surveying 1,204 teeth treated endodontically,
temporarily with zinc oxideeugenol cement. The full Dutch investigators reported an incidence of 30% post-
crown binds the remaining tooth structure much as the operative pain: 7% with severe symptoms and 23%
hoops contain the staves of a barrel. with moderate symptoms.50 By far the greatest number
If the incomplete fracture has entered the pulp of cases of postoperative pain (65%) were related to
and a true pulpalgia indicates that pulpitis is present, patients who reported at the first appointment with
then root canal therapy should be completed first, preoperative pain. In contrast, only 23% of those who
followed by full coverage to prevent a total fracture. If developed postoperative pain were free of pain initial-
the fracture has extended completely through, into ly. Most postoperative pain occurred on the first day
the periodontal ligament and pulp, the chances of after initiating endodontic treatment. Emergency treat-
saving the entire tooth are remote indeed. The possi- ment was necessary in 57% of the patients to relieve the
bility of saving a portion of the tooth is discussed in pain. Analgesics satisfied the rest.50
chapter 12. In a subsequent study, the Dutch team further ana-
lyzed a subsection of the cohort of 803 patients with
POSTOPERATIVE PAIN: INCIDENCE, 1,204 teeth, mostly completed in one appointment1
PREVENTION, AND TREATMENT hour for single canal cases and 2 hours for molars.51 A
There is no question that a good deal of postoperative positive correlation was found in the case of a nonvi-
pain is associated with endodontic therapy. This is one tal pulp in conjunction with preoperative pain on the
of the factors that continues to affect the public day of treatment [and] when a radiolucency larger than
adversely concerning root canal therapy. Some of these 5 mm in diameter is present. The chance of postoper-
problems are unavoidable, but many are iatral. Apical ative pain also increases with the number of root canals
overextension of necrotic debris (infected or other- in the tooth. The probability of postoperative pain was
wise), instruments, paper points, medicaments, and reduced in any case with a vital pulp.51
filling materials lead to postoperative pain. Apical per- A US Navy group has also reported that patients
foration is a common occurrence that can mainly be who were asymptomatic at the start of treatment expe-
avoided by careful attention to establishing and main- rienced a low incidence of postoperative pain.52 As one
taining correct working length. would expect, they also found that pulpectomy signifi-
cantly reduced postoperative pain in patients who had treatment, they did not imply that occlusal relief
reported initially with preoperative pain. More recent- should be abandoned in cases of acute apical abscess
ly, it was reported that complete pulpectomy was the (AAA) or acute apical periodontitis (AAP).60
most effective method of preventing postoperative pain
in those patients presenting with preoperative PERIRADICULAR PAIN
toothache in teeth with vital pulpitis. The next most Periradicular pain may be almost as excruciating as pulp
effective method was pulpotomy and the least effective pain and may often continue for a longer period of
was partial pulpectomy, which was twice as likely to time. Periradicular lesions that may produce discomfort
allow pain to continue.53 are (1) SAP, (2) SAA, (3) asymptomatic apical abscess
Chronic postoperative pain following endodontic (AAA), and (4) apical cyst. The adjective acute, as used
surgery is quite unusual, even though immediate post- here, refers to the severity and the rapidity of the course
surgical acute pain is expected. One survey, however, of the lesion. Acute apical periodontitis is by far the
classified 5% (6 cases) of a cohort of 118 cases as most distressing periradicular lesion.
endodontic failures because of continuing pain for an
average of 21 months.54 It was determined that three of Symptomatic Apical Periodontitis
the six patients may have suffered from post-traumatic Symptoms. This acute form of periradicular pain
dysesthesia, pain associated with the manipulation of can be most excruciating and sometimes lasts for days.
the root or apical boneIf nerve injury occurs, an The tooth is exquisitely painful to touch, and even con-
abnormal repair process is possible. The remaining tacting the tooth in closure may bring a flood of tears.
three failures were thought to be phantom tooth The pain is most persistent, lasting 24 hours a day.
pain. The duration of pain in this group prior to treat- The pain has been described as constant, gnawing,
ment was 1, 4, and 36 months, respectively.54 throbbing, and pounding. Eventually, the patient may
gain blessed relief, only to bite on the tooth while eating
PREOPERATIVE THERAPY or during sleep, which starts the pain cycle once more.
A number of studies have been done evaluating the Many patients beg to have the tooth extracted. Yielding
efficacy of preoperative medication of cases suspected to their wishes, this has been done only to have the pain
as potential troublemakers.52,5458 The Navy group continue for another 48 hours owing to osteitis.
(above) found that the preoperative administration of There is no overt swelling involved, just a grossly
flurbiprofen (a nonsteroidal anti-inflammatory drug painful tooth elevated slightly in its socket. One week of
[NSAID]) significantly reduced postoperative pain discomfort is to be expected if nothing is done!
compared to placebos.52 A group in Pittsburgh also Etiology. The degree of discomfort described in
recommended the use of an NSAID, the shorter-acting the preceding paragraphs may be iatral. That is, the cli-
ibuprofen, as a preoperative prophylactic against the nician perforates the root apex during endodontic
possibility of postoperative pain.59 therapy, forces caustic medicaments or irritating solu-
Morse and his group at Temple University achieved tions through the apical foramen, or forcibly deposits
similar results with the prophylactic administration of necrotic, infected, and toxic canal contents into the
diflunisal (a long-acting NSAID).55 They also found periradicular tissue. These irritants produce a violent
that the intracanal use of a corticosteroid solution fol- inflammatory reaction. If bacteria are present in the
lowing pulpectomy was efficacious.56 These results canal and are extruded apically, an acute abscess also
were similar to those of their previous studies with develops to complicate the picture.
antibiotics.57 Typically, SAP follows initial endodontic treatment.
The value of oral dexamethasone (corticosteroid) The mandibular premolars and molars are the teeth
following initial endodontic treatment has also been most frequently and violently involved, the premolars
reported.58 especially. This fact could be attributed to their invit-
Questioning the time-honored procedure of pro- ingly straight, tapered canals, which encourage abuse of
phylactically relieving the occlusion of posterior teeth the periapex with a reamer or file. Furthermore, the
being treated endodontically, a group at Iowa thick bony cortex and the small amount of cancellous
University found that there was no statistically signifi- bone found in this area limit the space allowable for
cant difference between routine occlusal relief and swelling. This limitation greatly increases the pressure
placebo relief.60 Although they could state that their in the area and hence the pain.
results cast doubt on the practice of routinely relieving Examination. Diagnosis of SAP is relatively easy;
the occlusion of posterior teeth receiving endodontic the patient is in severe pain, and the involved tooth is
exquisitely painful to touch. The tooth is in supraoc- eye/ear drops, sterile suspension, Upjohn Co., Peapack,
clusion, and the mandible cannot be closed without N.J.), is recommended as an anti-inflammatory/antibac-
initial impact on the involved tooth. terial medicament. The canal is flooded with this liquid
Treatment. The soundest treatment of AAP is its suspension and then, very gently, the fluid is teased out
prevention. Care in instrumentation is the most signif- of the trephined apex with a fresh sterile instrument. A
icant preventive measure. Care in medication is anoth- loose cotton pellet is then placed in the chamber and a
er precautionary measure. Overmedication and irritat- thin temporary filling placed without undue pressure.
ing medicaments cause a high percentage of these exas- The canal should not be filled to overflowing with the
perating cases. Virtually all of the intracanal medica- corticoid solution to allow space for inflammatory
ments used today are toxic to periradicular tissue. It is swelling. There will be some lag time before the
essential, therefore, that medicaments be confined to antiphlogistic effect of the hydrocortisone takes place.
the pulp chamber, that canals not be flooded with If the tooth continues to be painful after the analge-
medicaments, and that paper points saturated with a sia wears off, the patient is instructed to return to the
drug not be sealed in canals. office to have the procedure repeated. Removing the
In spite of precautionary measures, SAP may still temporary (with a dam in place) once again allows for
develop. When it does, the greatest problem involves drainage, and the canal is again medicated with
maintaining the patient in comfort for the entire peri- neomycin 1.5%. The temporary is replaced to prevent
od of healing and repair. To allow a patient to remain in secondary contamination. Each time the rubber dam is
violent, uncontrolled pain borders on criminal neglect. removed, the occlusion should again be checked.
When the patient reports with these acute symptoms, Frequently, further adjustment is necessary because the
the tooth need only be touched to determine the loca- tooth has again been elevated in the alveolus. The
tion. To relieve the pain, an immediate injection of a patient is warned not to eat on this side; however, the
long-lasting local anesthetic, such as bupivacaine warning is usually superfluous.
(Marcaine) with epinephrine 1:200,000, should be given. When the patient is leaving the office, he should be
As soon as the tooth is comfortable under anesthe- instructed that if the pain becomes unbearable at night,
sia, the occlusion should be adjusted to free the tooth he can remove the temporary at home. He should be
completely from contact in closure or in any excur- shown in a mirror how to pick out the thin temporary
sion. If possible, occlusal corrections should be made filling by using a safety pin that has been straightened
in the opposite arch to prevent more insult to the into a right angle. Exposed to the saliva, the canal, of
affected tooth. course, becomes contaminated. This is a modest prob-
A rubber dam should then be placed and the tem- lem, however, compared to a sleepless night of pain
porary filling removed very carefully. The tooth must that might be suffered by the patient.
be supported with the fingers to prevent further trau- In a further attempt to reduce or eliminate post-treat-
ma. Using paper points with great care, the chamber ment pain, Liesinger and colleagues reported the suc-
and canal should be cleared of any liquid contents. An cessful use of dexamethasone (corticosteroid), injected
instrument is placed in the canal, short of the regis- intraorally or intramuscularly, to suppress pain.61,62 In a
tered tooth length, and a radiograph is taken to check more objective laboratory study, a group at San Antonio,
the original tooth length. The present determination of Texas, quantitated the effect of dexamethasone as an
accurate tooth length is most important. Earlier instru- anti-inflammatory drug.63 After producing acute peri-
mentation at an elongated, inaccurate tooth length may radicular lesions in rat molars by overinstrumentation,
be the basis for the present serious trouble. When the they injected either dexamethasone or a saline control in
length of the tooth is re-established, a reamer with an the buccal vestibule opposite the no-insulted teeth. They
instrument stop should be set for this exact length and found that the dexamethasone produced a significant
then employed to just barely perforate (trephine) anti-inflammatory effect as measured by the number of
through the apical foramen. Sometimes this brings polymorphonuclear neutrophil leukocytes that were
forth a flow of blood and fluid, which materially counted in the area.63
reduces the periradicular pressure. This must be done The patient should also be carried on systemic
in a dry, clean canal and with the greatest caution not antibiotics and an anti-inflammatory drug, such as
to further traumatize the periradicular tissue. ibuprofen (Motrin), naproxen (Naprosyn), diflunisol
The advent of the corticosteroids as anti-inflammato- (Dolobid), or piroxicam (Feldene), for 4 days. By that
ry agents has improved the treatment of SAP. Hydro- time, the problem should have been resolved. For
cortisone, combined with neomycin (Neo-Cortef 1.5% greater detail, see chapter 18.
The patient should also be given a narcotic for anal- tooth also is extremely painful to percussion or palpa-
gesia: 30 to 60 mg (0.5 to 1 grain) of codeine is the ini- tion. Radiographically, the picture may vary from a
tial prescription, taken every 3 hours with 10 g aspirin. widened periodontal space to a large alveolar radiolu-
If the patient does not obtain relief from codeine or cency. Actually, the radiograph is not the best means of
cannot tolerate the drug, 50 to 100 mg meperidine diagnosis because it frequently reveals nothing of true
(Demerol) is prescribed every 4 hours, depending on diagnostic value.
the patients age and weight. A few patients have had Outside of percussion, electric pulp testing is the
such intense, prolonged pain that they required mor- best method of diagnosis because the pulp of the tooth
phine. Other patients have found it necessary to return involved in AAA is invariably necrotic. The vitality test,
every 5 or 6 hours for injections of local anesthetic into moreover, is the best criterion to differentiate an AAA
the affected area. from an acute periodontal abscess. In the case of the
Alveolar trephination is another means of relieving periodontal abscess, the pulp of the involved tooth is
the severe pain of SAP. Trephination, or surgical fistu- not likely to be necrotic, although, by chance, it could
lation, is thoroughly discussed in Chapter 12. be. Percussion proves that the periodontal abscess is
In any event, the patient should be seen daily until the not as painful as the apical abscess. The reason is quite
symptoms have resolved. Endodontic therapy should clear. The periodontal abscess is a lateral abscess,
not be undertaken until the tooth is comfortable. found on the side of the root, so that percussion caus-
Acute Apical Abscess. The pain of AAA is similar es little increase in pressure. On the other hand, per-
to that described for AAS but somewhat lower in inten- cussion against the inflamed periapex of the tooth with
sity. After all, necrosis is an extension of the inflamma- AAA induces a great increase in pressure owing to the
tory cycle, which begins with acute apical periodontitis wedging effect of the tapering root.
and continues to the abscess state if not checked. The adjacent teeth involved in the swollen area may
Necrosis of the acute abscess usually destroys also be painful to percussion, and they register an
enough tissue to permit fluid dispersement. The increased reading on the pulp tester owing to the col-
extravasated fluid breaks out into the soft tissue and lateral edema. The adjacent teeth, however, are not
marrow spaces where swelling is not as confined as it nearly as painful to percussion as the involved tooth
was at the periapex. This is not to say that the AAA is and usually register within normal limits in pulp test-
not painful. On the contrary, it is quite painful, but in ing. Multiple loss of vitality may follow an accident so
comparison with SAP, the unbearable pain has gone that a number of adjacent teeth could test nonvital, but
and in its place is a full systolic throbbing pain, partic- usually only one is abscessed.
ularly on palpation. The involved tooth is also painful In contrast to percussion, thermal tests have little
to movement or mastication. value. Extremes of heat may increase gas expansion in
Etiology. The discomfort of AAA develops gradu- the area and thereby increase the pain momentarily.
ally as the abscess grows in size. The condition is invari- Cold may give slight relief but usually does nothing at
ably related to bacterial invasion of the periradicular all. Palpation of the area reveals the swelling, and the
region from a necrotic, infected pulp canal. The abscess pressure increases the discomfort.
may develop spontaneously from an infected pulpless Treatment. Under a special section devoted to
tooth or may follow initial endodontic treatment if these problems in Chapter 12, treatment of the AAA is
bacteria are forced into the periradicular tissue. discussed in detail. Suffice it to say here that drainage is
In any event, the initial discomfort may be mild but established through the root canal if the abscess is in its
gradually builds in intensity as the abscess becomes initial stage, or by incision if the abscess is fluctuant.
indurated or hardened. When the alveolar plate is Trephination may also be performed to establish
eroded by the process and the abscess gathers into drainage and relieve pressure. The occlusion is relieved
frank pus, the entire area softens and feels fluctuant to and a regimen of systemic antibiotics and either hot
palpation, and the pain is greatly reduced. rinses or cold applications is prescribed for the patient
Examination. Diagnosis of AAA is a relatively sim- depending on the stage of development of the abscess.
ple matter. The patient has pain and, invariably, The pain often can be controlled with mild anal-
swelling. Although the swelling may not always be gesics such as acetaminophen. However, hydrocodone
observable to the examiner, the patient feels the tense- or meperidine (Demerol) must be prescribed for severe
ness of the swollen area. The degree of swelling varies cases.
from the initial, undetected swelling to gross cellulitis Endodontic therapy or extraction, whichever is indi-
and massive asymmetry (see Figure 511). The involved cated, is completed after the acute symptoms have sub-
sided and while the patient is still receiving antibiotics. Periradicular surgery is sometimes indicated for these
Periradicular surgery is rarely necessary in treating pathologic lesions. The chronic lesion that becomes
these cases. acutely infected must be treated as an AAA until the
Chronic Apical Periodontitis. Chronic apical symptoms have subsided. The tooth may then be han-
periodontitis is seldom painful and is thoroughly dis- dled as an endodontic case or extracted, as conditions
cussed in chapter 5 under Periradicular Pathology. indicate.
Treatment. Endodontic therapy is usually indicated Apical Cyst. The apical cyst, per se, is painless
for the tooth involved with CAP. This is sometimes fol- unless it becomes infected. In that event, the case
lowed by periradicular surgery, but only where indicated. should be handled as an AAA. The apical cyst is dis-
Chronic Apical Abscess. Also called suppurative cussed in chapter 5 under Periradicular Pathology.
apical periodontitis, CAA is generally free of symp- Treatment. When treated endodontically, the
toms. There may be stages in the long history of such a apical cyst may be enucleated during periradicular
lesion when a draining fistula closes, and mild swelling surgery.
and discomfort ensue. The patient reports that the
abscess drains daily or that opening the abscess with a PERIODONTAL LESION PAIN
needle relieves the discomfort. Few periodontal lesions are severely painful. The caus-
Many cases of suppurative apical periodontitis are es of these lesions are divided into diseases that attack
so painless that they go undetected for years until just the gingiva and those that involve the deeper peri-
revealed by radiography. odontal complex. Two uncomfortable lesions that
Etiology. Chronic apical abscess is the inflamma- involve the gingiva and mucosa are acute necrotizing
tory response to an infection by bacteria of low viru- ulcerative gingivitis and herpes simplex. These dis-
lence from the root canal. As stated previously, the only eases offer no severe problems in the differential diag-
discomfort associated with a CAA is that related to the nosis of pain because both lesions are diagnosed from
occasional closing of the draining fistula with attendant their appearance and/or odor.
pressure. This chronic lesion, however, may develop an Two painful conditions that involve the pericemen-
acute exacerbation, the phoenix abscess, and when this tal structures and must be differentiated are the acute
happens, the patient has all of the problems of an AAA. gingival or periodontal abscess and pericoronitis.
In this event, the pain and swelling are magnified
owing to the large preexisting lesion. Acute Gingival or Periodontal Abscess
Examination. On questioning, the patient with a The patient with an acute periodontal abscess seeks
previously undetected CAA may remember a particu- treatment for a tooth that is painful to move or to bite
larly stormy session in the involved area or perhaps a on. The pain, however, is not as deep-seated or throb-
traumatic incident in which the pulp was devitalized by bing as that of an AAA. Although some localized
a blow. There has been no discomfort since, however. swelling is present, it is not as extensive as with the AAA.
Chronic apical abscess is frequently associated with Etiology. The acute periodontal or gingival
long-standing dental restorations such as full gold or abscess develops from a virulent infection of an exist-
jacket crowns, large composites or amalgams, and ing periodontal pocket or as an apical extension of
extensive bridgework. Occasionally, a routine radi- infection from a gingival pocket. Most gingival
ograph reveals a CAA, associated with a discolored abscesses are associated with traumatic injury to the
anterior tooth. This may appear as an area of diffuse gingiva or periodontium by a mechanical force. Both
radiolucency around the apex of the tooth in question types of abscess are frequently seen in patients who
and may vary from a minor lesion to a massive loss of have compulsive clenching or bruxism.
bone. External resorption of the root end is also a com- Examination. Although the involved tooth may be
mon finding. painful to movement, it is not as painful as the tooth
The lesion of CAA, easiest to detect, has an associat- involved in an AAA. Furthermore, the location of the
ed draining fistula, usually intraoral, seldom cuta- abscess is usually different; the periodontal abscess
neous. This sinus tract, lined with inflammatory tissue, points opposite the coronal third of the root, whereas
drains the abscess through a stoma into the oral cavity. the apical abscess generally points opposite the apex.
It is the closing of this tract that causes the patient dis- The electric pulp tester is the surest method of dif-
comfort. ferentiation. The necrotic, infected pulp causing an
Treatment. If the tooth involved with CAA can be apical abscess always gives an essentially negative
saved, it may be retained by endodontic therapy. response to testing, whereas the tooth involved with the
periodontal abscess is generally vital. Use of the peri- pathways are frequently encountered, and the clinician
odontal probe often reveals a tract from the gingival soon comes to realize that almost any reference, except
sulcus to the abscess. across the midline, is possible.
Treatment. The reader is referred to a periodontics Symptoms. Glick has well illustrated referred pain
text for information on treatment. from pulpalgiafrom tooth to tooth and from tooth to
nearby cutaneous and deep structures.64 Figures 7-9
Pericoronitis and 7-10 illustrate this information to facilitate diag-
The common complaint of the patient with pericoro- nosis by visual association.64
nitis is severe radiating pain in the posterior mouth The leading published scientific study on pulp pain
and the inability to comfortably open or close the and referred pain is that of Robertson et al.65 These
mandible. Not only is it painful to close against the authors produced toothache by placing stimulating
inflamed operculum distal to the erupting mandibular electrodes into defects in the enamel of their own teeth.
molar, but the pain of muscle trismus limits translation They found that by delivering up to 10.0 volts to the
of the mandible as well. The tissue distal to the erupt- teeth, severe pain could be induced. Moreover, they dis-
ing molar is most painful to touch, especially during covered that when they maintained the shock for 10
eating. The pain radiates through the region, down into minutes, the pain would be referred out of the teeth
the neck, and up into the ear and can easily be confused and over the entire distribution of the involved division
with pulp pain. Occasionally, an erupting third molar of the nerve. Systematically and cleverly, these
elicits the same deep, spreading pain well before the researchers mapped and described the reference pain
tooth breaks through the oral epithelium. from a number of teeth, mandibular and maxillary
Etiology. Pericoronitis is caused by injury and alike (Figures 7-11 and 7-12).
infection of the pericoronal tissue associated with What Roberston et al. described from experimenta-
erupting molars, usually mandibular third molars. The tion has been seen countless times by dentiststhe
tissue may be injured during eating by trauma from patient with advanced acute pulpalgia who is suffering
food such as peanuts or bread crust. The infection localized and referred pain with all of the attendant sys-
begins under the operculum and extends with atten- temic signs and symptoms. They further experimented
dant swelling around the entire unerupted crown. This with the reduction of referred pain first by injecting
area is frequently a source of primary infection with anesthetics into the area of referred pain on the face
Borrelia vincentii and Fusiformis dentium. and scalp and, second, into the area of the original
Examination. The history of trismus and discom- noxious stimulation, that is, the tooth.65 As Figure
fort on opening or closing the mandible is indicative of 7-13 demonstrates, only partial relief from pain devel-
pericoronitis. When the operculum is palpated or oped following procaine injection into the referred
probed, it is found to be swollen and exquisitely area; however, complete relief from pain was experi-
painful. The patient usually assumes that it is the tooth enced when the region of the original source of pain
that is painful. was anesthetized.
Pericoronitis must sometimes be differentiated Robertson et al. also found that protracted pain, as
from a periodontal abscess commonly occurring along found in osteomyelitis of the mandible, led to sustained
the distal aspect of the second molars. Again, the peri- contraction and pain of the muscles of the face, head, and
odontal abscess is not nearly as painful as pericoronitis. neck. In this case (Figure 7-14), when the source area of
Treatment. The reader is referred to an oral surgery pain in the mandible was anesthetized, the referred pain
text for information on treatment of pericoronitis. area involved with the third division of the fifth nerve was
REFERRED PAIN abolished. On the other hand, the pain areas owing to
spasm of the muscles of the neck continued. The phe-
Referred Pulp Pain nomenon of myofascial trigger point pain and dysfunc-
One of the most frequently encountered and most baf- tion developing as a result of pulpalgia is exactly the
fling phenomena with which the dental diagnostician reverse of referred tooth or jaw pain from spasm of the
must deal is the problem of referred pulp pain. Texts trapezius muscle or the muscles of mastication as
and articles discussing this subject frequently give pat described by Travell (see Figures 8-28, 8-29, and 8-30).66
rules of pain reference with the implication that if The interesting research of Ray and Wolff would
pain is to be referred from a tooth, it is always referred seem to confirm the reference of deep pulp pain into
in a particular pattern. This is not so, as anyone active more superficial and cutaneous associated regions but
in diagnosis soon discovers. Quite bizarre reference could hardly be construed to explain the pain referred
A B
C D
E F
Figure 7-9 Referred pain pathways from teeth involved with pulpalgia to other teeth as well as to the immediate area.
Black signifies tooth with pulpalgia; stippled areas, the site of referred pain. A, The maxillary canine may refer to the max-
illary first or second premolars and/or the first or second molars, as well as to the mandibular first or second premolars.
B, Maxillary premolars may refer pain to the mandibular premolars. The reverse is also true. C, Mandibular incisors,
canine, and first premolar may refer pain into the mental area. D, The mandibular second premolar may refer pain into
the mental and midramus area. E, Mandibular first or second premolars may also refer pain into maxillary molars. F,
Mandibular molars may refer pain forward to the mandibular premolars. Adapted with permission from Glick DH.64
A B
C D
E F
Figure 7-10 Pain referred from pulpalgia to structures remote from the involved tooth. Black indicates teeth involved in
pulpalgia; stippled areas, remote areas of referred pain. A, Maxillary incisors may refer pain to frontal area. B, Maxillary
canine and first premolar may refer pain into the nasolabial area and orbit. C, The maxillary second premolar and first
molar may refer pain to the maxilla and back to the temporal region. D, Maxillary second and third molars may refer pain
to mandibular molar area and occasionally into the ear. E, Mandibular first and second molars may commonly refer pain
to the ear and to the angle of the mandible. F, The mandibular third molar may refer pain to the ear and occasionally to
the superior laryngeal area. Adapted with permission from Glick DH.64
Figure 7-11 Pain referred from a maxillary second premolar. Pain was initially experienced
locally in the tooth following noxious stimulation by 10 volts of electricity. Within 5 min-
utes, numbness, fullness in the ear, and muscle stiffness had developed, in addition to steady
pain along the homolateral temporal, zygomatic, and supraorbital areas. The headache
reached its maximum distribution and intensity within 20 minutes after cessation of
toothache. Reproduced with permission from Wolff HG. Headache and other head pain.
New York: Oxford University Press; 1950.
Figure 7-12 Electrical stimulation of a lower first molar maintained severe toothache for 10
minutes. Pain was referred into the ear canal and throughout the upper and lower jaws, over the
zygoma and temple, to the top of the ear; a sensation of fullness and ache persisted in the ear.
Numbness and stiffness of the masseter muscle developed. Twenty minutes after stimulation,
severe lower-half headache developed throughout the region. Reproduced with permission
from Wolff HG. Headache and other head pain. New York: Oxford University Press; 1950.
Figure 7-13 Broad area of referred pain developed from maxillary third molar pulpalgia. Injecting procaine into the
referred area alleviated pain only at the site of injections. All primary and referred pain was totally eliminated by inject-
ing at the site of primary noxious stimuli (third molar). Reproduced with permission from Wolff HG. Headache and
other head pain. New York: Oxford University Press; 1950.
Figure 7-14 Protracted pain from a lower premolar caused not only widespread referred pain (see Figure 7-10) but
also pain from spasm of muscles of the face, head, and neck. Anesthetizing the primary source of pain alleviated pain
referred along two divisions of the fifth nerve but did not relieve spasm and pain of muscles of the neck. The reverse
is also true. Myofascial pain from these muscles will refer into the oral cavity. Reproduced with permission from Wolff
HG. Headache and other head pain. New York: Oxford University Press; 1950.
from one tooth to another or from the paranasal tissue Habit reference was verified by Hutchins and
into the teeth.67 This type of referred pain has been dis- Reynolds, who demonstrated that teeth filled without
cussed by Ruch and Fulton as habit reference.68 benefit of local anesthesia could be made to ache when
Evidence that reference of sensation is a learned phe- the homolateral nasal wall was stimulated by a needle
nomenon, they stated, can be found in the clinical prick in the vicinity of the maxillary sinus ostium.69
observation that a pain may be referred not to its usual Ruch and Fulton, in reviewing the research of Hutchins
point of reference but to the site of a previous surgical and Reynolds, looked on the traumatized sensory nerves
operation, trauma, or localized pathological process.68 of involved dental pulps as a learned response.68 They
stated further, The pain impulses from the sinus, con- lowed since 1979 from a cohort of 120 cases, revealed that
ducted in an overlapping pathway, were simply given the 81% of the patients were female and ranged from 13 to 80
previously learned reference for impulses in that path.68 years of age (mean 42.6 years). The pain was located in the
This same thought may be projected to explain how teeth, jaws, or gingiva 93% of the time. However, 14% said
pain in one tooth (possibly even in the opposing that the pain affected areas of the facethe cheek and
homolateral arch) could be referred there from pulpitis around the eyes and ears. Only 4% reported tongue pain.
in another tooth some distance away. The pulp of the The onset of the pain was precipitated by dental proce-
referred tooth might well have been previously trauma- dures 31% of the time. Tricyclic and monoamine oxidase
tized by caries, a blow, or a dental procedure without inhibitor antidepressant therapy relieved pain in many of
anesthesia. This injured pulp then becomes the fertile the cases.72 Because it falls within the descriptive area of
ground on which the seeds of referred response could atypical facial neuralgia, this type of pain will be dis-
be sown in the future. This might also explain why pain cussed further in that section of chapter 8.
is referred to teeth when the patient has mumps or
inflammation of the temporomandibular joint. Salivary Gland Disorders
Continuing further with their studies, Reynolds and The salivary glands can be affected by many diseases,
Hutchins found that they could virtually eliminate including obstruction, infection, degeneration, and
referred pulp pain by procaine block anesthesia.70 This tumor growth. Pain and tenderness, however, are usu-
was done by repeating their previous experiment in ally found in association with inflammation of the
which they performed traumatic dental work without gland itself. In Sjgrens syndrome, parotitis is also
anesthesia on both sides of the maxillary arch and later accompanied by diminished salivation and lacrimation
demonstrated that pain was referred to these teeth from and some other connective tissue disorder, such as
a pinprick of the maxillary ostium in the nose. After this lupus erythematosus or rheumatoid arthritis.73 Pain
fact was well established, the teeth on the right side were from any of these conditions will refer to the teeth. For
all anesthetized. Two weeks following these injections, further details, see chapter 8.
the right side was again tested with stimulation of the
ostium. Amazingly, no referred pain could be elicited on Ear Pain
any tooth that had been previously anesthetized. On the Pain within the ear can be caused by a disease within
left side, however, which had not been anesthetized, the the ear and related structures as with otitis media or
teeth still responded with referred pain when the left mastoiditis. Pain may also be referred to the ear from
maxillary ostium was stimulated. Therefore, the impor- many other head and neck structures including the
tance of rendering dental treatment under local anesthe- teeth, temporomandibular joint, tonsils, tongue,
sia is emphasized by Reynolds and Hutchins since pain throat, trachea, and thyroid.74 This is because the ear is
was not referred to teeth treated under local anesthesia.70 innervated by cranial nerves V, VII, VIII, IX, X, XI, and
C1, C2, and C3.
EXTRAORAL PAIN
As explained above, pain from sources outside the Sinus and Paranasal Pain
oral cavity may refer into the oral cavity. The reverse Sinusitis is a common cause of dull, constant pain.75
is also true. The location of this pain can vary from the maxilla and
These diagnostic and treatment problems will be maxillary teeth in maxillary sinusitis to the upper orbit
dealt with in some depth in chapter 8. To complete the and frontal process in frontal sinusitis, between and
record, however, these sites will merely be mentioned at behind the eyes in ethmoid sinusitis, and at the junction
this point. of the hard and soft palate, occiput, and mastoid process
in sphenoid sinusitis. Pain from the sinuses may be
Atypical Toothache referred into the oral cavity, the teeth in particular. The
Rees and Harris described a disorder that they called atyp- reverse is also true; that is, pain from the teeth or from
ical odontalgia.71 Patients present themselves with all of periradicular lesions may be discerned as sinus pain or
the typical features of an acute toothachesevere, throb- may be the source of maxillary sinus disease.75 Selden
bing, continuous pain starting in one quadrant but has pointed out, in discussing the oral-antral syndrome,
spreading even across the midline. Also referred to as that about 25% of chronic maxillary sinusitis is second-
dental migraine or phantom tooth pain, this condition ary to dental infections.76 Because of the extraoral
is often associated with patients suffering from unipolar, nature of sinus and paranasal pain and disease, it will be
or common, depression. A recent review of 28 cases, fol- considered in greater depth in chapter 8.
Myocardial Infarction, Coronary Thrombosis, 3. Yamana M. In: Anderson DJ, editor. Sensory mechanism in
Angina Pectoris, and Thyroid Disease. dentine. New York: Macmillan; 1963. p. 78.
4. Brnnstrm M. In: Anderson DJ, editor. Sensory mechanism
It is hard to imagine that a site as distant from the oral in dentine. New York: Macmillan; 1963. p. 78.
cavity as the heart may refer pain into the teeth and 5. Brnnstrm M. The hydrodynamic theory of dentinal pain:
jaws. But refer it does, in a most confusing manner. The sensation in preparations, caries, and the dentinal crack
syndrome. JOE 1985;12:453.
diagnostician must be quite astute to recognize that the
6. Beveridge EE. Measurement of human dental intrapulpal pres-
toothache described by the patient is actually reflect- sure and its response to clinical variables [masters thesis].
ing serious cardiac disease. Seattle (WA): Univ. of Washington; 1964.
Other sources of referred pain to the jaws are car- 7. Shoher I, Mahler Y, Samueloff S. Dental pulp photoplethys-
diospasm (spasm of the esophageal cardiac sphincter mography in human beings. Oral Surg 1973;36:915.
associated with hiatal hernia of the diaphragm) and 8. Funakoshi M, Zotterman Y. In: Anderson DJ, editor. Sensory
mechanism in dentine. New York: Macmillan; 1963. p. 69.
thyroid disease. In addition to these pain references, 9. Brnnstrm M. In: Anderson DJ, editor. Sensory mechanism
women have reported oral discomfort associated in dentine. New York: Macmillan; 1963. p. 72.
with the menopause43% of peri- and post- 10. Kleinberg I. Dentinal hypersensitivity, part I: the biologic basis
menopausal women reporting oral pain compared of the condition. Compend Contin Educ 1986;7:182.
with only 6% of premenopausal women.77 Two- 11. Trowbridge HO. Review of dental painhistology and physi-
ology. JOE 1986;12:445.
thirds of the menopausal women reporting discom-
12. Wallace JA, Bissada NF. Pulpal and root sensitivity related to
fort were relieved of their symptoms after hormone periodontal therapy. Oral Surg 1990;69:743.
replacement therapy.77 13. Anderson DJ. Sensory mechanisms in dentine. New York:
Also reported is pain from non-Hodgkins lym- Macmillan; 1963. p. 89.
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intrapulpal pressure and its response to clinical variables.
er incidence of this disease in patients with acquired
Oral Surg 1965;19:655.
immune deficiency syndrome (AIDS).78 15. Nahri MVO. The characteristics of intradental sensory units
Because of the extraoral nature of these sources of and their responses to stimulation. JDR 1985;64:564.
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17. Brnnstrm M. The cause of postrestorative sensitivity and its
CONCLUSION prevention. JOE 1986;12:475.
18. Kleinberg K. Dentinal hypersensitivity, part II: treatment of
In conclusion, one could state that the vast majority of sensitive dentin. Compend Contin Educ 1986;7:281.
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ment through tubule occlusion. JOE 1986;12:465. 62. Marshall JG, Liesinger AW. Factors associated with endodontic
38. Bahram J, et al. Cyanoacrylatea new treatment for hypersen- posttreatment pain. JOE 1993;19:573.
sitive dentin and cementum. J Am Dent Assoc 1987;114:486. 63. Nobuhara WK, et al. Anti-inflammatory effects of dexametha-
39. Calamia J, et al. Effect of Amalgambond (a 4-meta bonding sone on periradicular tissues following endodontic overin-
agent) on cervical sensitivity [abstract]. JDR 1992;71:132. strumentation. JOE 1993;19:501.
40. Ianzano JA, Gwinnett J. Polymeric sealing of dentinal tubules 64. Glick DH. Locating referred pulpal pains. Oral Surg
to control sensitivity. JDR 1992;71:205. 1962;15:613.
41. Stanley HR, Swerdlow H. Reactions of the human pulp to cav- 65. Robertson S, Wolff, Goodell. The teeth as a source of headache
ity preparation: results produced by eight different opera- and other pain. Arch Neurol Psychiatry 1947;57:277.
tive grinding techniques. J Am Dent Assoc 1959;58:49. 66. Travell, J. Temporomandibular joint dysfunction: temporo-
42. Hahn C-L, et al. Correlation between thermal sensitivity and mandibular joint pain referred from muscles of the head
microorganisms isolated from deep carious lesions. JOE and neck. J Prosthet Dent 1960;10:745.
1993;19:26. 67. Ray BS, Wolff HG. Experimental studies on headache. Pain
43. Hodosh M, et al. Potassium nitrate: an effective treatment for sensitive structures of the head and their significance in
pulpitis. Oral Surg 1983;55:419. headache. Arch Surg 1940;41:813.
44. Glick DH. Lecture before the American Association of 68. Ruch TC, Fulton JF. Medical physiology and biophysics. 18th
Endodontists, April 1983. ed. Philadelphia: WB Saunders; 1960.
45. Kier DM, et al. Thermally induced pulpalgia in endodontical- 69. Hutchins HC, Reynolds OE. Experimental investigation of the
ly treated teeth. JOE 1991;17:38. referred pain of aerodontalgia. J Dent Res 1947;26:3.
46. Newsviews. Ice the pain. Calif Dent Assoc J 1988;16:51. 70. Reynolds OE, Hutchins HC. Reduction of central hyper-irri-
47. Kollman W. Incidence and possible causes of dental pain dur- tability following block anesthesia of peripheral nerve. Am
ing simulated high altitude flights. JOE 1993;19:154. J Physiol 1948;152:658.
48. Rauch JW. Barodontologiadental pain related to ambient 71. Rees RT, Harris M. Atypical odontalgia. Br J Oral Surg
pressure change. Gen Dent 1985;33:313. 197879;16:212.
49. England MC, et al. Histopathologic study of the effect of pul- 72. Schnurr RF, Brooke RI. Atypical odontolgia. Oral Surg
pal disease upon the nerve fibers of the human dental pulp. 1992;73:445.
Oral Surg 1974;38:783. 73. Arthritis Foundation: primer on the rheumatic diseases.
50. Genet JM, et al. The incidence of postoperative pain in JAMA 1973;224:663.
endodontic therapy. Int Endodont J 1986;19:221. 74. Birt D. Headaches and head pains associated with diseases of
51. Genet JM, et al. Preoperative and operative factors associated the ear, nose and throat. Med Clin North Am 1978;62:523.
with pain after the first endodontic visit. Int Endodont J 75. Boles R. Paranasal sinuses and facial pain. In: Alling CC,
1987;20:53. Mahan PE, editors. Facial pain. 2nd ed. Philadelphia: Lea &
52. Flath RK, et al. Pain suppression after pulpectomy with preop- Febiger; 1977. p. 11534.
erative flurbiprofen. JOE 1987;13:339. 76. Selden HS. Annual meeting, American Association of
53. Oguntebi BR, et al. Postoperative pain incidence related to the Endodontists, April 1990.
type of emergency treatment of symptomatic pulpitis. Oral 77. Wardrop RW, et al. Oral discomfort at menopause. Oral Surg
Surg 1992;73:479. 1989;67:535.
54. Campbell RL, et al. Chronic facial pain associated with 78. Bavitz JB, et al. Non-Hodgkins lymphoma disguised as odon-
endodontic therapy. Oral Surg 1990;69:287. togenic pain. J Am Dent Assoc 1992;123:99.
Chapter 8
NONODONTOGENIC TOOTHACHE AND
CHRONIC HEAD AND NECK PAINS
Bernadette Jaeger
Pain is perfect misery, the worst of evils; and excessive, overturns discomfort, distress, or agony resulting from the stim-
all patience. ulation of specialized nerve endings.1 In this defini-
John Milton, Paradise Lost tion, the behavioral reaction to nociception is already
assumed to be distress or agony, which is not always
Patients with chronic oral or facial pain, or headache, the case. Take, for example, the observations made by
present a true diagnostic and therapeutic challenge to Beecher in 1956 that only 25% of soldiers wounded in
the practitioner. For many in the dental profession, the battle requested narcotic medications for pain relief,
only solution to problems of pain lies with a scalpel, for- compared to more than 80% of civilian patients with
ceps, or ever-increasing doses of analgesics, narcotics, or surgical wounds of a similar magnitude.2 Clearly, the
sedatives. Many patients with chronic pain have suffered behavioral reaction to similar nociceptive stimuli
this mistreatment and stand as an indictment of a poor- varies from person to person and depends on a num-
ly trained, insecure, and disinterested segment of den- ber of factors, including the significance of the injury
tistry. Attending to patients who have been unable to to that individual. The wounded soldier may be
obtain resolution of their pain complaint, despite exten- relieved to be out of a life-threatening situation; the
sive evaluation and treatment, requires a compassionate surgical patient may be concerned about recurrence of
reappraisal and fresh approach. Fortunately, accurate a tumor just removed. Dorlands definition also
diagnosis and successful management of these patients implies that stimulation of nociceptors is required for
can be among the most rewarding experiences in dental perception of pain, yet the dental patient who has been
or medical practice. anxious for weeks in anticipation of the needle at the
dentists office may jump in agony at the slightest
WHAT IS PAIN? touch of his cheek.
Pain is not a simple sensation but rather a complex Fields defined pain as an unpleasant sensation that
neurobehavioral event involving at least two compo- is perceived as arising from a specific region of the body
nents. First is an individuals discernment or percep- and is commonly produced by processes that damage
tion of the stimulation of specialized nerve endings or are capable of damaging bodily tissue.3 He empha-
designed to transmit information concerning potential sized the need to be able to localize the painful source
or actual tissue damage (nociception). Second is the in order to distinguish it from psychological pain and
individuals reaction to this perceived sensation (pain suffering, for example, the pain of a broken heart.
behavior). This is any behavior, physical or emotional, A more complete definition is cast by the
that follows pain perception. Culture or environment International Association for the Study of Pain (IASP)
often influences these behaviors. Beyond this is the suf- in its taxonomy of painful disorders.4 That definition
fering or emotional toll the pain has on any given indi- of pain is as follows: An unpleasant sensory and emo-
vidual. Suffering is so personal that it is difficult to tional experience associated with actual or potential
quantify, evaluate, and treat. tissue damage, or described in terms of such damage.
The fact that pain is difficult to define, quantify, and Added to this definition, however, is the following,
understand is reflected in the numerous ways in which emphasizing the subjective nature of pain that distin-
it has been described. Dorlands Medical Dictionary guishes and separates it from the simple stimulation of
defines pain as a more or less localized sensation of nociceptors:
Pain is always subjective. Each individual learns To understand pain better, this chapter first looks at
the application of the word through experiences what is currently known about the anatomy and phys-
related to injury in early life. It is unquestionably a iology of the nociceptive pathways and some of the
sensation in a part of the body, but it is also always modulating influences that modify the nociceptive
unpleasant and therefore also an emotional expe- input into the central nervous system. Following this,
rience. Many people report pain in the absence of various psychological and behavioral factors that influ-
tissue damage or any likely pathophysiological ence the perception of and reaction to pain are
cause, usually this happens for psychological rea- reviewed.
sons. There is no way to distinguish their experi-
ence from that due to tissue damage, if we take the NEUROPHYSIOLOGY OF PAIN
subjective report. If they regard their experience as The following summarizes what is known about the
pain and if they report it in the same ways as pain basic anatomy and physiology of pain under normal
caused by tissue damage, it should be accepted as physiologic conditions5:
pain. This definition avoids tying pain to the stim-
ulus. Activity induced in the nociceptor and noci- Acute Pain Pathways
ceptive pathways by a noxious stimulus is not pain, The body has specialized neurons that respond only to
which is always a psychological state, even though noxious or potentially noxious stimulation. These neu-
we may well appreciate that pain most often has a rons are called primary afferent nociceptors and are
proximate physical cause.4 made up of small-diameter thinly myelinated A delta
and unmyelinated C fibers (Figure 8-1). They synapse
The IASP definition of pain makes the point that in the substantia gelatinosa of the dorsal horn of the
pain is pain even if a nociceptive source is not readily spinal cord with neurons known as second-order pain
identified. Pain owing to psychological causes is as real transmission neurons. From here the signals are trans-
as any pain associated with actual nociception and mitted along specialized pathways (spinothalamic and
should be treated as such. reticulothalamic tracts) to the medial and lateral
regions of the thalamus (Figure 8-2). Perception of nociceptor. Bradykinin further contributes by causing
nociception may occur in the thalamus and cortex, but the sympathetic nerve terminal to release a
the exact location is unknown, and the contribution of prostaglandin that also stimulates the nociceptor.6
the cortex to pain perception is controversial.3 Additionally, in an area of injury or inflammation, the
Fields divided the processing of pain from the stimu- sympathetic nerve terminal will release yet another
lation of primary afferent nociceptors to the subjective prostaglandin in response to its own neurotransmitter,
experience of pain into four steps: transduction, trans- norepinephrine. The presence of such an ongoing
mission, modulation, and perception.3 Transduction is inflammatory state causes physiologic sensitization of
the activation of the primary afferent nociceptor. the primary afferent nociceptors.6 Sensitized nocicep-
Primary afferent nociceptors can be activated by intense tors display ongoing discharge, a lowered activation
thermal and mechanical stimuli, noxious chemicals, threshold to normally nonpainful stimuli (allodynia),
and noxious cold. They are also activated by stimula- and an exaggerated response to noxious stimuli (pri-
tion from endogenous algesic chemical substances mary hyperalgesia).7
(inflammatory mediators) produced by the body in In addition to sending nociceptive impulses to
response to tissue injury. Damaged tissue or blood cells synapse in the dorsal horn of the spinal cord, activation
release the polypeptide bradykinin (BK), potassium, of cutaneous C fibers causes their cell bodies to synthe-
histamine, serotonin, and arachidonic acid. Arachidonic size the neuropeptides, substance P and calcitonin
acid is processed by two different enzyme systems to generelated peptide (CGRP). These neuropeptides
produce prostaglandins and leukotrienes, which, along are then antidromically transported along axon
with BK, act as inflammatory mediators (Figure 8-3). branches to the periphery by an axon transport system
Bradykinin acts synergistically with these other chemi- where they induce further plasma extravasation and
cals to increase plasma extravasation and produce increase inflammation. The release of these algogenic
edema. Plasma extravasation, in turn, replenishes the substances at the peripheral axon injury site produces
supply of inflammatory chemical mediators. Whereas the flare commonly seen around an injury site and is
prostaglandins stimulate the primary afferent nocicep- referred to as neurogenic inflammation or the axon
tor directly, the leukotrienes contribute indirectly by reflex79 (Figure 8-4).
causing polymorphonuclear neutrophil leukocytes to Transmission refers to the process by which periph-
release another chemical, which, in turn, stimulates the eral nociceptive information is relayed to the central
Figure 8-3 Membrane lipids produce arachidonic acid, which is converted to prostaglandins by the cyclooxygenase enzyme and to
leukotriene B4 by the lipoxygenase enzyme. Prostaglandins act directly on the primary afferent nociceptor to lower the firing threshold and
therefore cause sensitization. Leukotriene B4 cause polymorphonuclear neutrophil leukocytes (PMNLs) to produce another leukotriene
that, in turn, acts on the primary afferent nociceptor to cause sensitization. Steroids prevent the synthesis of arachidonic acid altogether, thus
inhibiting both pathways of prostaglandin production. Nonsteroidal anti-inflammatory drugs (NSAIDs), on the other hand, inhibit only the
cyclooxygenase pathway.
stimuli) will also activate second-order nociceptive An endogenous opioid system for pain modulation
dorsal horn neurons, producing what is called a sec- also exists.17 Endogenous opioid peptides are natural-
ondary mechanical hyperalgesia in the area sur- ly occurring pain-dampening neurotransmitters and
rounding the initial tissue injury7,15 (Figure 8-5). neuromodulators that are implicated in pain suppres-
Modulation refers to mechanisms by which the sion and modulation because they are present in large
transmission of noxious information to the brain is quantities in the areas of the brain associated with these
reduced. Numerous descending inhibitory systems activities (subnucleus caudalis and the substantia
that originate supraspinally and strongly influence gelatinosa of the spinal cord).17,18 They reduce noci-
spinal nociceptive transmission exist.16 In the past, ceptive transmission by preventing the release of the
only midline structures such as the periaqueductal gray excitatory neurotransmitter substance P from the pri-
and nucleus raphe magnus were known to be involved mary afferent nerve terminal. The presence of these nat-
in descending nociceptive modulation (Figure 8-2). ural opioid receptors for endogenous opiates permits
Now many sites previously thought to be primarily morphine-like drugs to exert their analgesic effect.
involved in cardiovascular function and autonomic The final step in the subjective experience of pain is
regulation (eg, nucleus tractus solitarius; locus perception. How and where the brain perceives pain is
ceruleus/subceruleus, among others) have also been still under investigation. Part of the difficulty lies in the
shown to play a role in pain modulation.16 The ascend- fact that the pain experience has at least two compo-
ing nociceptive signal that synapses in the midbrain nents: the sensory-discriminatory dimension and the
area activates the release of norepinephrine (NE) and affective (emotional) dimension. The affective dimen-
serotonin, two of the main neurotransmitters involved sion of pain is made up of feelings of unpleasantness
in the descending inhibitory pathways.16 Activity in the and emotions associated with future implications relat-
pain modulation system means that there is less activi- ed to the pain.19 Although functional magnetic reso-
ty in the pain transmission pathway in response to nox- nance imaging (MRI) studies have demonstrated the
ious stimulation. involvement of the thalamus and multiple cortical
areas in the perception of pain, it is clear from the
intersubject variability in the activation of any one of
these areas that affective reactions and possibly motor
responses are also involved.20
Of significance is the fact that, with high levels of
modulation, or with damage in the pain transmission
system, it is possible to have nociception without pain
perception. Conversely, with certain types of damage to
the nervous system, there may be an overreaction to
pain stimuli or pain perception without nociception.3
Referred Pain
Pain arising from deep tissues, muscles, ligaments, joints,
and viscera is often perceived at a site distant from the
actual nociceptive source. Thus, the pain of angina pec-
Figure 8-5 Central sensitization and allodynia. Input from C- toris is often felt in the left arm or the jaw, and diaphrag-
nociceptors enhances the response of dorsal horn pain-signaling matic pain is often perceived in the shoulder or neck.
neurons to subsequent afferent inputs (central sensitization). This Whereas cutaneous pain is sharp, burning, and clearly
involves neuropeptides such as substance P (SP) acting at neu- localized, referred pain from musculoskeletal and viscer-
rokinin receptors (NKR) and excitatory amino acids (EAA) acting
at both the AMPA/KA and N-methyl-D-aspartate (NMDA) recep-
al sources is usually deep, dull, aching, and more diffuse.
tors, triggering secondary NO (nitric oxide) mechanisms. Large- Referred pain presents a diagnostic dilemma. If left
diameter low-threshold mechanoreceptive primary afferents (A unrecognized, it may result in a clinician telling a
beta fibers) respond maximally to innocuous tactile stimuli and patient that his pain is psychogenic in origin.
normally produce tactile sensation. When central sensitization is Treatments directed at the site of the pain are ineffec-
present, A beta fibers become capable of activating central nervous
tive and, if invasive, subject the patient to unnecessary
system pain-signaling neurons (+), leading to touch-evoked pain
(allodynia). Reproduced with permission from Fields HL, risks, expense, and complications. However, referred
Rowbotham M, Baron R. Neuralgia: irritable nociceptors and deaf- pain is dependent on a primary pain source and will
ferentation. Neurobiol Dis 1998;5:209. cease if this source is eliminated.
The mechanism of referred pain is still somewhat points (TrPs), for which application of a vapo-
enigmatic. The two most popular theories are conver- coolant spray is actually a popular and effective
gence-projection and convergence-facilitation: modality used for pain control.
1. Convergence-projection theory: This is the most The mechanism of referred pain from myofascial
popular theory. Primary afferent nociceptors from TrPs is also under speculation. According to Mense, the
both visceral and cutaneous neurons often converge convergence-projection and convergence-facilitation
onto the same second-order pain transmission neu- models of referred pain do not directly apply to muscle
ron in the spinal cord,21 and convergence has been pain because there is little convergence of neurons from
well documented in the trigeminal brainstem deep tissues in the dorsal horn.28 Based on experimen-
nuclear complex.2225 The trigeminal spinal tract tally induced changes in the receptive field properties
nucleus also receives converging input from cranial of dorsal horn neurons in the cat in response to a deep
nerves VII, IX, and X, as well as the upper cervical noxious stimulus29 (Figure 8-7), Mense proposed that
nerves.26,27 The brain, having more awareness of convergent connections from other spinal cord seg-
cutaneous than of visceral structures through past ments are unmasked or opened by nociceptive input
experience, interprets the pain as coming from the from skeletal muscle and that referral to other
regions subserved by the cutaneous afferent fibers myotomes is owing to the release and spread of sub-
(Figure 8-6). stance P and CGRP to adjacent spinal segments28
2. Convergence-facilitation theory: This theory is sim- (Figure 8-8). Simons has expanded on this theory to
ilar to the convergence-projection theory, except specifically explain the referred pain from TrPs30
that the nociceptive input from the deeper struc- (Figure 8-9). Myofascial pain (MFP) is discussed in
tures causes the resting activity of the second-order more detail later in the chapter.
pain transmission neuron in the spinal cord to
increase or be facilitated. The resting activity is Trigeminal System
normally created by impulses from the cutaneous An appreciation of the arrangement of the trigeminal
afferents. Facilitation from the deeper nociceptive nociceptive system provides some insight into the inter-
impulses causes the pain to be perceived in the area esting pain and referral patterns that are encountered in
that creates the normal, resting background activity. the head and neck region. The primary afferent noci-
This theory tries to incorporate the clinical observa- ceptors of the fifth cranial nerve synapse in the nucleus
tion that blocking sensory input from the reference caudalis of the brainstem. The nucleus caudalis is the
area, with either local anesthetic or cold, can some- caudal portion of the trigeminal spinal tract nucleus
times reduce the perceived pain. This is particularly and corresponds to the substantia gelatinosa of the rest
true with referred pain from myofascial trigger of the spinal dorsal horn (Figure 8-10). From here the
nociceptive input is transmitted to the higher centers
via the trigeminal lemniscus. Of significance is the
arrangement of the trigeminal nerve fibers within this
nucleus and the fact that the nucleus descends as low as
the third and fourth cervical vertebrae (C34) in the
spinal cord. Fibers from all three trigeminal branches
are found at all levels of the nucleus, arranged with the
mandibular division highest and the ophthalmic divi-
sion lowest.31 In addition, they are arranged in such a
manner that fibers closest to the midline of the face
synapse in the most cephalad portion of the tract. The
more lateral the origin of the fibers on the face, the
more caudal the synapse in the nucleus (Figure 8-11).
Figure 8-6 The convergence-projection hypothesis of referred Understanding this laminated arrangement helps to
pain. According to this hypothesis, visceral afferent nociceptors (S) explain why a maxillary molar toothache may be per-
converge on the same pain-projection neurons as the afferents from ceived as pain in a mandibular molar on the same side
the somatic structures in which the pain is perceived. The brain has
no way of knowing the actual source and mistakenly projects the
(referred pain) but not in an incisor. Similarly, pain per-
sensation to the somatic structure. Reproduced with permission ceived in the ear may actually be owing to (or referred
from Fields HL.3 from) an infected third molar.
Figure 8-7 Changes in receptive field (RF) properties of a dorsal horn neuron following intramuscular injection of a painful dose of
bradykinin (BKN). A, Location and size of the original RF (black) before BKN injection. The neuron required noxious deep pressure stim-
ulation (Nox. p. deep) of the proximal biceps femoris muscle for activation. The arrow points to the injection site in the anterior tibial mus-
cle (TA). B, left, 5 minutes after the BKN injection, two new RFs were present (black), both of which were located in deep tissues and had a
high mechanical threshold. B, right, 15 minutes after the BKN injection, the original RF displayed a lowering in mechanical threshold and
now responded to moderate (innocuous) deep pressure (Mod. p. deep). Reproduced with permission from Mense S.28
Figure 8-10 Primary afferent nociceptive fibers of the trigeminal nerve (cranial nerve V) synapse in the nucleus caudalis of the spinal
trigeminal tract. The nucleus caudalis descends as low as C34 in the spinal cord. Many nociceptors from deep cervical structures synapse
on the same second-order pain transmission neurons as the trigeminal nerve. This may explain why cervical pain disorders are often per-
ceived as facial pain or headache.
Because the trigeminal nucleus descends to the C34 by the apparent discrepancy between the identifiable
level in the spinal cord, primary afferent nociceptors nociceptive source, which may seem very small, and the
from deep cervical structures synapse on the same sec- amount of suffering and disability seen. It becomes
ond-order pain transmission neurons that subserve the easy to label these patients as crazy or malingering
fifth cranial nerve.32 This convergence of primary affer- (deliberately, fraudulently feigning an illness for the
ent nociceptors from the trigeminal region and the cer- purpose of a consciously desired outcome).1 Yet there
vical region provides a basis for understanding why are both physiologic and psychological mechanisms
cervical pain disorders may be perceived as pain in the that may increase pain perceptionmechanisms that
head and face, particularly in the forehead and tem- help to explain why there may be a discrepancy
plethe lateral ophthalmic trigeminal fibers synapse between actual nociception, perceived pain, and the
the lowest (see Figure 8-11). apparent resultant suffering and disability.
Physiologic Mechanisms Modifying Pain.
Chronic Pain Sensitization. As previously discussed, primary affer-
Pain becomes complicated and difficult to manage ent nociceptors become sensitized through the release
when it is prolonged. Often the clinician is frustrated of endogenous substances caused by tissue injury. As a
injured.35 Thus, a peripheral injury may set up a posi- and tolerance to pain vary in relation to many cogni-
tive feedback loop through activation of the sympa- tive, affective (emotional) factors.
thetic nervous system that will perpetuate the activa- Cognitive and Affective Factors. Sensory factors
tion of the primary afferent nociceptors. The extreme include the detection, localization, quantification, and
result of this type of sympathetic hyperactivity is a con- identification of the quality of a particular stimulus.
dition known as reflex sympathetic dystrophy (dis- Reaction to the stimulus, the intensity of desire to ter-
cussed in more detail later in this chapter). In this syn- minate the stimulus, is determined by cognitive and
drome, the pain, even from a minor injury, does not affective variables. Cognitive variables include such
subside and, in fact, develops into a progressive, excru- things as an individuals past experience with similar
ciating burning pain with cutaneous hypersensitivity. stimuli, their psychological makeup, and societal and
The pain may occur in a site larger than and different cultural factors. Affective variables relate to emotions
from that of the original injury; autonomic signs such and feelings and determine how unpleasant the stimu-
as vasoconstriction or sweating of the painful area are lus is to the individual. Affective descriptors of a senso-
usually present. The sympathetic nervous system is ry experience might include words such as nagging,
strongly implicated because sympathetic blockade uncomfortable, intense, or killing, in contrast to
abolishes the pain. Mild forms of this self-perpetuating sensory features such as mild burning, localized to
loop of sympathetic activity and primary nociceptive the palate, or aching over the TMJ.
response may explain why pain sometimes worsens, Affective variables may be accompanied by anxiety
even when the injury has healed. or depression and are influenced by expectation and
Psychological Factors Modifying Pain. Three thresh- suggestion. For example, most people are not particu-
olds for sensation and pain help in understanding the larly distressed about having a headache since the vast
subjective experience of pain. Sensory threshold, majority of headaches are not pathologic. Yet someone
pain threshold, and pain tolerance (or response whose sibling recently died of a brain tumor might be
threshold) refer to the specific levels in the sensory con- much more worried and anxious about this same
tinuum where intensity of stimulation meets a change in symptom, even if it is very mild. Similarly, recurrence
conscious experience. Joy and Barber used an example of of pain owing to cancer carries with it the knowledge
a human subject, stimulated with an increasing-intensi- that the disease may be progressing and may remind
ty electrical current to the finger, to help distinguish each the individual of his mortality. This type of pain will
of the thresholds.36 have many more emotional components and may be
The first time the subject reports perception of any perceived as much more severe.
sensation is termed the sensory threshold. This is Another good example is the anxious dental patient
defined as the lowest level of stimuli that will cause who jumps in agony at the first touch of the cheek.
any sensationthe summation of large sensory fibers Even though the sensation of touch is well below his
from receptors for touch, temperature, and vibration. experimental pain threshold, the patient perceives it
As the current is increased, the sensation becomes and reacts to it as painful. Conversely, a person experi-
stronger until the subject states that it is painful. encing analgesia through hypnosis may perceive no
This is the pain threshold and has been shown to be sensations or only nonpainful sensations while under-
fairly constant among individuals.15,37 Neurologically, going normally painful procedures such as tooth
when the summation of firing of primary afferent extraction or pulp extirpation.38,39
nociceptive fibers reaches a certain point, pain is per- Frontal lobotomy reduces or abolishes the affective
ceived. If the intensity of the electrical current is component to pain, without disturbing pain threshold
increased above pain threshold, a level of pain will be or pain intensity,23 supporting the idea that affective
reached that the subject can no longer endure. This is components of pain are processed in different areas of
pain tolerance or the response threshold. At this the brain from sensation.
point, the individual makes an attempt to withdraw Behavioral Factors. Suffering and pain are commu-
from the stimulus. nicated through actions such as moaning, limping, gri-
The range between the pain threshold and response macing, guarding, pill taking, or visiting the doctor.
threshold is termed a persons tolerance to pain, that is, These actions are termed pain behaviors. Pain behav-
the amount of pain that can be tolerated after pain is iors follow basic learning principles and tend to
first perceived. Although the pain threshold is relative- increase unconsciously if they are rewarded by positive
ly constant among different people, pain tolerance consequences. Positive consequences may include
varies greatly. This is because perception of sensations attention from loved ones and/or the medical/dental
system and avoidance of various aversive tasks and Otherwise, a disproportionately high frequency of 5s
responsibilities. Since chronic pain conditions, by defi- and 10s will be chosen.41 Patients are asked to place a
nition, last a long time, they provide an opportunity for slash mark somewhere along the line to indicate the
unconscious learning to occur. The pain behaviors intensity of their current pain complaint. For scoring
observed in a patient with chronic pain may be the purposes, a millimeter ruler is used to measure along
cumulative result of intermittent positive reinforce- the line and obtain a numeric score for the pain ratings.
ment over months or years. In addition, well behaviors Most people understand this scale quickly and can eas-
are often totally ignored and nonreinforced, causing ily rate their pain. Children as young as 5 years are able
them to decrease. to use this scale.42 Its reliability and validity for meas-
Just as positive reinforcement causes an increase in uring pain relief have been demonstrated.43,44
particular behaviors, so will nonreinforcement cause a The use of the scale should be clearly explained to
decrease. Thus, even when the nociceptive source has the patient. For measuring treatment outcome, relief
diminished or healed, pain perception and attendant scales (a line anchored with no pain relief and com-
disability may be maintained through learned pain plete pain relief ) may be superior to asking absolute
behaviors along with physical, cognitive, and affective pain intensities.45 Similarly, if a pain intensity visual
factors.40 A more complete description of learned behav- analog scale was used, patients may be more accurate if
ior in pain is given in the section on psychogenic pain. they are allowed to see their previous scores.46 Caution
is advised with photocopying because this process usu-
PAIN ASSESSMENT TOOLS ally lengthens the line and introduces error.
Pain is a subjective experience that is communicated to McGill Pain Questionnaire. The McGill Pain
us only through words and behaviors. Unlike measur- Questionnaire (Table 8-1) is a verbal pain scale that
ing blood pressure, temperature, or erythrocyte sedi- uses a vast array of words commonly used to describe a
mentation rate, measuring pain intensity is extremely pain experience. Different types of pain and different
difficult. As discussed above, there are several physio- diseases and disorders have different qualities of pain.
logic and psychological factors that will influence the These qualitative sensory descriptors are invaluable in
intensity of pain perceived. Other cognitive, affective, providing key clues to possible diagnoses. Similarly,
behavioral, and learning factors affect how this pain is patients use different words to describe the affective
communicated. component of their pain.
Nonetheless, measuring pain is important, not just To facilitate the use of these words in a systematic
for studying pain mechanisms in a laboratory but also way, Melzack and Torgerson set about categorizing
to assess treatment outcome. To this end, a number of many of these verbal descriptors into classes and sub-
instruments have been developed and tested for their classes designed to describe these different aspects of
reliability and validity in measuring different aspects of the pain experience. In addition to words describing
the pain experience. the sensory qualities of pain, affective descriptors
including such things as fear and anxiety and evaluative
Quantifying the Pain Experience words describing the overall intensity of the pain expe-
Visual Analog Scales. A visual analog scale is a line rience were included.47
that represents a continuum of a particular experience, The words are listed in 20 different categories (see
such as pain. The most common form used for pain is Table 8-1). They are arranged in order of magnitude
a 10 cm line, whether horizontal or vertical, with per- from least intense to most intense and are grouped
pendicular stops at the ends. The ends are anchored by according to distinctly different qualities of pain. The
No pain and Worst pain imaginable (Figure 8-13). patients are asked to circle only one word in each cate-
Numbers should not be used along the line to ensure a gory that applies to them. Patients are usually happy to
better, less biased distribution of pain ratings. select from this list of pain-describing adjectives, often
Figure 8-13 Visual analog pain scale used to indicate patients level of daily pain. The patient places a mark at the perceived level of dis-
comfort. The scale is 10 cm, so direct measurement can subsequently be made.
Sensory
1 2 3 4 5
Flickering Jumping Pricking Sharp Pinching
Quivering Flashing Boring Cutting Pressing
Pulsing Shooting Drilling Lacerating Gnawing
Throbbing Stabbing Cramping
Beating Lancinating Crushing
Pounding
6 7 8 9 10
Tugging Hot Tingling Dull Tender
Pulling Burning Itchy Sore Taut
Wrenching Scalding Smarting Hurting Rasping
Searing Stinging Aching Splitting
Heavy
Affective
11 12 13 14 15
Tiring Sickening Fearful Punishing Wretched
Exhausting Suffocating Frightful Gruelling Blinding
Terrifying Cruel
Vicious
Killing
Evaluative Miscellaneous
16 17 18 19 20
Annoying Spreading Tight Cool Nagging
Troublesome Radiating Numb Cold Nauseating
Miserable Penetrating Drawing Freezing Agonizing
Intense Piercing Squeezing Dreadful
Unbearable Tearing Torturing
saying, Now I can tell exactly how it feels. Before I amount of emotional or psychological overlay accom-
couldnt think of just the right words. panying the pain (categories 11 through 15). Changes
The first 10 categories represent different sensory in a patients pain experience can be monitored by
descriptors that cover various temporal, spatial, pressure, administering the questionnaire at various time points
and thermal qualities of pain. The next five categories are during treatment and follow-up.
affective or emotional descriptors, category 16 is evalua- Melzack used this master list of words to derive
tive (ie, how intense is the pain experience), and the last quantitative measures of clinical pain that can be treat-
four categories are grouped as miscellaneous. ed statistically; if used correctly, it can also detect
To score the questionnaire, the words in each cate- changes in pain with different treatment modalities.48
gory are given a numeric value. The first word in each
category ranks as 1, the second as 2, etc. The scores for Psychological Assessment
each category are added up separately for the sensory, Chronic pain is the most complicated pain experi-
affective, evaluative, and miscellaneous groupings. ence and the most perplexing and frustrating problem
Then the total number of words chosen is also noted. in medicine and dentistry today. Because chronic pain
Using this questionnaire, it is possible to obtain a sense syndromes have such a complex network of psycholog-
of the quality of a patients pain complaint (categories ical and somatic interrelationships, it is critical to view
1 through 10), its intensity (category 16), and the the patient as an integrated whole and not as a sum of
individual parts. Determining the emotional, behav- Systematic assessment of psychosocial difficulties
ioral, and environmental factors that perpetuate chron- that interfere with work and interpersonal activities is
ic pain is as essential as establishing the correct physical important but often neglected. The dentist should
diagnosis or, in many chronic cases, multiple diagnoses. include questions to elicit information about oral
Almost all patients with chronic head and neck pain habits, depression, anxiety, stressful life events, lifestyle
have physical findings contributing to their complaint. changes, and secondary gain (operant pain) in the clin-
Similarly, almost all patients with chronic head and ical interview. To decide which patient should be
neck pain have psychological components to their pain referred for a full psychological assessment, the clinician
as well. Contributing to the complex neurobehavioral evaluating a patient with chronic pain may choose to
aspects of pain is the fact that chronic pain is not self- use simple questionnaires that are easy to administer, do
limiting, seems as though it will never resolve, and has not take long to fill out, and are reliable and adequate
little apparent cause or purpose. As such, multiple psy- psychological screening tools. The Multidimensional
chological problems arise that confuse the patient and Pain Inventory (MPI),49 Beck Depression Inventory
perpetuate the pain. Patients feel helpless, hopeless, and (BDI/BDI-II),*50,51 and Chronic Illness Problem
desperate in their inability to receive relief. They may Inventory (CIPI)52 fulfill this purpose, although many
become hypochondriacal and obsessed about any other reliable instruments also exist. Patients who score
symptom or sensation they perceive. Vegetative symp- high on any of these inventories should be sent to a psy-
toms and overt depression may set in, with sleep and chologist or psychiatrist familiar with chronic pain for a
appetite disturbances. Irritability and great mood fluc- more complete workup. Psychologists or psychiatrists
tuations are common. Loss of self-esteem, libido, and may use the Minnesota Multiphasic Personality
interest in life activities adds to the patients misery. All Inventory (MMPI/MMPI-II),53 in addition to the BDI-
of this may erode personal relationships with family, II and other psychological instruments, as part of their
friends, and health professionals. Patients focus all of comprehensive assessment.
their energy on analyzing their pain and believe it to be
the cause of all of their problems. They shop from doc- MAKING A DIAGNOSIS
tor to doctor, desperately searching for an organic cure. Diagnosing orofacial disease and headaches follows
They can become belligerent, hostile, and manipulative the same principles as any medical diagnosis. Of pri-
in seeking care. Many clinicians make gallant attempts mary importance is a careful and exhaustive history.
with multiple drug regimens or multiple surgeries, but This alone will often point directly to a specific diag-
failure frustrates the clinician and adds to the patients nosis or at least reveal a diagnostic category. The his-
ongoing depression. tory is followed by a physical examination, which
Near the end of this progression, in addition to their should help to confirm or rule out the initial diagnos-
continuing pain, many of these patients have multiple tic impression. If necessary, further diagnostic studies
drug dependencies and addictions or high stress levels; such as pulp testing, nerve blocks, radiographs, or
they may have lost their jobs, be on permanent disabil- blood tests may be carried out or ordered at this time.
ity, or be involved in litigation. These may help rule out serious disorders and provide
Herein lies the importance of proper psychological information complementing the history and physical
diagnosis as well as accurate physical diagnosis. An examination. Finally, if doubt concerning the diagno-
appropriate evaluation should include consideration of sis persists, or pathosis out of ones area of expertise
all factors that reinforce and perpetuate the pain com- exists, other medical specialists and health care
plaints. Examining factors contributing to pain aggra- providers may provide valuable consultation.
vation can include a look at stress (current and cumu-
lative), interpersonal relationships, any secondary gain
the patient may be receiving for having the pain, per- *The BDI and BDI-II can be obtained by contacting the
ceptual distortion of the pain, and poor lifestyle habits Psychological Corporation, 555 Academic Court, San Antonio, TX
such as inadequate diet, poor posture, and lack of exer- 78204.
cise. This information may well point to the reasons Copies of the CIPI can be obtained by contacting Dr. Bruce
why patients have been unsuccessfully treated in the Naliboff, PhD, Clinical Professor, Department of Psychiatry and
past. Obtaining baseline measures of pain levels, drug Biobehavioral Sciences, Co-Director, CURE Neuroenteric Disease
intake, functional impairment, and emotional state is Program, UCLA Division of Digestive Disease, VA Greater Los
Angeles Healthcare System, Building 115, Room 223, 11301
important and will help monitor a patients progress Wilshire Boulevard, Los Angeles, CA 90073; Tel: 310-268-3242; Fax
through rehabilitation. 310-794-2864.
Begin by pondering the scenario of the following case. local pathosis of the extracranial or intracranial struc-
tures and referred pain from pathema of more distant
Case History organs such as the heart must be ruled out first. This
A 33-year-old woman presents herself for evalu- covers a wide variety of infectious, inflammatory,
ation of intense left-sided facial pain. The pain is degenerative, neoplastic, or obstructive processes that
described as a constant burning sensation that can affect any organ in the head, neck, and thorax,
radiates from the left preauricular area to the orbit, including the brain (see Tables 8-7 through 8-9). Most
zygoma, mandible, and, occasionally, shoulder. Her dentists and physicians are well trained to evaluate a
pain is exacerbated by cold air, cold liquids, chew- patient for such pathosis.
ing, smiling, and light touch over certain areas of There are other disorders, however, that cause pain
her face. She also reports a constant pinching sen- in the head and neck region that cannot be attributed
sation over her left eyebrow and mandible and pho- to any obvious diseases of the craniofacial, craniocervi-
tophobia in the left eye. She is currently taking high cal, thoracic, or intracranial organs. These disorders are
doses of narcotics with little relief. less well appreciated and, for ease of clinical use, are
The pain began 1 year previously, after the best classified according to the apparent tissue origin of
extraction of a left maxillary molar. The extrac- the pain (see Table 8-2). For an exhaustive classification
tion site apparently developed a dry socket of headaches and facial pain that includes very specific
(localized osteomyelitis of the alveolar crypt). This diagnostic criteria, the reader is referred to the
was treated appropriately but without relief of the International Headache Societys publication.54
patients symptoms. Subsequently, two mandibu- The primary distinguishing feature of these diagnos-
lar molars on the same side were extracted in an tic categories is the quality of the pain. For example,
attempt to relieve the pain. These extraction sites vascular pain, such as with migraine, generally has a
likewise developed dry sockets and were treated, throbbing, pulsing, or pounding quality; neuropathic
again without pain relief. Local anesthetic injec- pain, for example, trigeminal neuralgia, is usually
tions twice daily for many months and a 4-week described as sharp, shooting, or burning and is restrict-
course of cephalosporin, given empirically for pos- ed to the peripheral distribution of the affected nerve
sible periodontal infection or osteomyelitis of the branch; muscle pain is usually deep, steady, and aching
mandible, were also unsuccessful. or produces a sensation of tightness or pressure.
In contrast, extracranial or intracranial pathema
To properly evaluate these rather confusing signs may present with any quality of pain. An inflamed
and symptoms, additional information is necessary. tooth pulp may throb with each heartbeat. A tumor
pressing on a nerve may cause sharp, lancinating, neu-
Classification ralgic-like pain. A sinus infection may be dull and
In evaluating orofacial pains and headaches, an easy- aching. Referred pain tends to be deep and poorly
to-use, practical, and clinical classification of these localized and have an aching or pressing quality.
pains will facilitate diagnosis (Table 8-2). In developing Once organic pathosis has been ruled out, a prelim-
such a classification, it is important to remember that inary diagnostic category can be chosen based on the
location and the quality of the pain. Therefore, when Table 8-3 History of Pain
taking a pain history, the first questions to ask are
Chief complaint
Where, exactly, do you feel your pain? How, exactly,
Characteristics of pain
does your pain feel to you? Please mark on this line
Location
how severe you consider your pain to be at its worst,
Quality
usual, and lowest. This will help guide further ques-
Temporal patterns
tioning to confirm or rule out a specific diagnosis with-
Constant or intermittent
in that group. For example, a patient may complain of
Duration of each attack if intermittent
a constant dull ache in front of the ear and a paroxys-
Diurnal variation in intensity if constant
mal lancinating pain that shoots from the ear to the
Seasonal variation of symptoms if any
chin and tongue. In this situation, two patterns of pain
Associated symptoms
are described. One points to a possibly myofascial or
Precipitating factors if intermittent
rheumatic diagnosis for the ear pain and the other to a
Aggravating factors
paroxysmal neuralgia for the shooting pain. Further
Alleviating factors
history, examination, and diagnostic tests will help
Symptoms severity range (lowest, usual, and highest
establish more definitive physical diagnoses. This sys-
pain intensities)
tematic approach is particularly helpful in chronic
Onset and history
pain, in which there are often multiple diagnoses, and
Past and present medications or other treatments for
psychological distress and pain behavior may confuse
pain
the diagnostic process.
Past medical and dental history
If the patient in the case outlined above does not
Family history
have any ongoing pathologic lesions of the extracranial
Social history
or intracranial structures, which categories of pain
Review of systems
would fit her description best? Based on the limited
information given, namely, a constant burning quality,
the most likely preliminary diagnostic categories are
neuropathic or sympathetic. To make a specific diagno- Different pains also have different temporal patterns
sis within a category, more specific information regard- or patterns of occurrence. For example, a patient may
ing the pain, its temporal pattern (timing of occur- complain of an intermittent, unilateral throbbing head
rence), associated symptoms, and aggravating and alle- pain. This would be the hallmark of a diagnosis in the
viating factors is needed. vascular category. The exact pattern of the pain will help
determine which vascular headache the patient is suf-
fering. For example, migraines last from 4 to 48 hours
History
and occur once or twice a year up to several times per
The key elements of taking a history for a pain com- month. Cluster headaches last less than 90 minutes each
plaint are delineated in Table 8-3. but occur several times a day, for several months, before
Establishing the patients chief complaint requires going into remission. Similar distinctions can be made
listening carefully as the patient describes each type of with neuropathic pains. The pain of trigeminal neural-
pain or complaint present, including the location, gia is seconds in duration and may be triggered fre-
quality, and severity of each symptom. Chronic pain quently throughout the day. The pain of a post-trau-
patients often have multiple pain complaints with dif- matic neuropathy or postherpetic neuralgia is constant.
ferent descriptions, which may indicate that multiple
diagnoses are involved. When this is the case, obtain- The temporal pattern for this patients burning
ing complete information on each pain complaint sep- pain is constant, with little daily variation.
arately simplifies the diagnostic process.
Often there are associated symptoms such as nausea,
The patient in the case scenario complains of vomiting, ptosis, nasal congestion, tingling, numbness,
only one pain. The location is over the left side of blurred vision, or visual changes that may precede or
the face, radiating from the preauricular area. The accompany the pain. These symptoms may point to a
quality of the pain is described primarily as burn- specific diagnosis. For example, visual changes may
ing. Her usual pain intensity on a 0 to 10 scale is 8, precede a migraine with aura. Nausea and vomiting
5 being the lowest and 9 being the highest. often accompany severe headaches, especially migraine.
Generalized malaise may accompany a temporal arteri- changed since onset, and what evaluations and treat-
tis. Autonomic changes, such as ptosis, nasal conges- ment have been tried in the past. For example, a histo-
tion, or conjunctival injection, almost always accompa- ry of skin lesions and malaise (herpes zoster) typically
ny cluster headaches or chronic paroxysmal hemicra- precedes postherpetic neuralgia. Acute trauma may
nia. Tingling and numbness may occur with de- precede a myofascial TrP pain complaint. In contrast,
afferentation (nerve damage) pains such as postherpet- psychological stress can trigger almost any type of pain
ic or post-traumatic neuralgias. complaint.
Unexplained neurologic symptoms, however, such Knowing which specialists the patient has seen,
as cognitive or memory changes, transient sensory or which tests and radiographs have already been com-
motor loss of the face or extremities, tinnitus, vertigo, pleted, what the previous diagnostic impressions have
loss of consciousness, or any of the above symptoms been, and which treatments have been tried helps the
not fitting an appropriate pain picture, must alert the practitioner in several ways. First, which workups are
health professional to the possibility of an intracranial still needed? Did the past workups adequately rule out
lesion, requiring further workup. Some of these symp- organic or life-threatening pathema? How long ago
toms may be normal bodily sensations enhanced were these workups completed? Have the symptoms
through distorted perceptions. Similarly, others, such changed since then? Do any of these workups need to
as tinnitus, vertigo, or sensory tingling, may be associ- be repeated? Second, what diagnoses were considered
ated with the referred symptoms of myofascial TrP in the past? Were appropriate medications or treat-
pain.55 Further diagnostic tests or consultations may be ments tried, in adequate doses and for long enough
needed to rule out more serious pathosis. periods of time? With acute pain, the history is usually
quite short, but with chronic pain, the history may
Associated symptoms for this patient include a take hours to obtain, the patient having seen many dif-
constant pinching sensation over her left eye- ferent health care providers in the past. With chronic
brow and mandible and photophobia of the left pain, the effect of past medications, surgeries, and
eye. She also describes occasional electric attacks other treatments may provide insight not only into the
that radiate out from the left TMJ. The electric etiology of the pain but also the psychological or
attacks she describes last anywhere from 30 min- behavioral status of the patient.
utes to 24 hours.
The pain began 1 year previously, after the
Precipitating, aggravating, and alleviating factors extraction of a left maxillary molar. The extrac-
also add clues to the origin of pain. Foods rich in tyra- tion site apparently developed a dry socket. This
mine may trigger a migraine attack.56 Light touch, was treated appropriately but without relief of the
shaving, or brushing teeth may precipitate an attack of patients symptoms. Subsequently, two left
trigeminal neuralgia. Cold weather, maintaining any mandibular molars were extracted in an attempt
one body position for a prolonged period of time, or to relieve the pain. These extraction sites likewise
overexercise will aggravate MFP. A dark room and rest developed dry sockets and were treated, again
will alleviate migraine but aggravate cluster headache. without pain relief. Local anesthetic injections
Heat and massage will alleviate muscular pain and twice daily for many months and a 4-week course
MFP but may aggravate an inflamed joint. of cephalosporin given empirically for possible
periodontal infection or osteomyelitis of the
The burning pain is constant, without precipi- mandible were also unsuccessful.
tating factors. Aggravating factors include cold
air, cold liquids, chewing, smiling, and light touch. This history tells us that, initially, local tooth patho-
The electric attacks are precipitated by light sis was suspected as the etiology of the pain. However,
touch over the preauricular area. At this stage, extraction of teeth provided no relief. Osteomyelitis
nothing alleviates the pain. High doses of nar- and possibly periodontal disease had also been suspect-
cotics barely serve to take the edge off. ed, but high-dose antibiotic treatment for osteomyelitis
also failed to provide pain relief. Are there other
Gathering information about the onset and history extracranial or intracranial pathemas that may need to
of the problem will provide further clues as to the eti- be ruled out?
ology of the complaint. Of interest are the events sur- A family history should include information regard-
rounding the initiation of the pain, how the pain has ing the patients parents and siblings. Are they alive and
well? If not, why not? Does anyone in the immediate The patient complains of decreased energy and
family suffer from a similar pain problem? For exam- sleep disturbance secondary to the pain. She has
ple, 70% of migraine patients have a relative who also no other complaints.
has or had migraine. Does anyone in the family have a
chronic illness? This person may provide a model for In acute pain problems, a firm diagnosis may be
pain behavior and coping. established almost immediately from the history. In con-
trast, diagnosis of a chronic pain complaint may take
The patients parents and siblings are alive and months of tests or trials despite an exhaustive history.
well. There is no history of similar illness or chron- The next step in diagnosis is a thorough physical
ic illness in her family. examination.
Physical Examination
A social history not only should cover demographic
information, marital status, household situation, and The physical examination for craniofacial pain may
occupation but should also seek to uncover any poten- vary slightly, depending on its location and the apparent
tial perpetuating factors to the pain. Look for potential cause. Pathosis of extracranial structures, particularly
stressors at work and at home and ask about postural the oral cavity, must be sought and ruled out first. This
habits, body mechanics, dietary habits, environmental usually involves inspection, palpation, percussion,
factors, and drug and alcohol use. transillumination, and auscultation of the tissues and
structures suspected of causing pain. Intraoral exami-
nation, which must include inspection of all intraoral
This patient lives in a rural farm area, has been
tissues, teeth, and periodontium, is discussed in detail in
married to the same man for 15 years, and has
chapters 6 and 7. Once acute pathema has been ruled
three children. She used to work on the farm but
out, the physical examination must be augmented to
has been unable to do so for the last 6 months include evaluation of the cranial nerves, temporo-
because of the pain. The patient has smoked one mandibular joint, cervical spine, and head and neck
pack a day for 18 years. She does not drink alcohol. muscles. In specific cases, a more comprehensive neuro-
Currently she spends most of her day in bed logic examination may be indicated. The basic compo-
because of the pain. nents of a physical examination are listed in Table 8-4.
General inspection can reveal a great deal about a
Since the patient lives in a rural area, the possibility patient to the alert clinician. A slouching posture can
of a coccal infection must be considered and ruled out. point to depression. Rigidity in posture or clenching is an
The past medical history may reveal some underly- indication of excess muscle tension in the neck, shoul-
ing illness such as lupus erythematosus or hypothy- ders, or jaws. Asymmetry, swelling, redness, and other
roidism that may predispose the patient to developing signs may indicate a neoplastic or infectious process.
pain. Past surgeries and medications for other purpos- Closer inspection of the head and neck may reveal scars
es, any psychiatric history, allergies, hospitalizations, of past surgeries, trophic skin changes associated with
and other illnesses must be included and may reveal reflex sympathetic dystrophy, or color changes from local
health care abuse. infection, systemic anemia, or jaundice.
The examination of the TMJs involves testing the
The patient states that she is otherwise in good range and quality of motion of the mandible, palpating
health. She had the usual childhood diseases, has and listening for joint noises, and palpating the lateral
no known allergies, and has been hospitalized
only for the birth of her children. There is no his-
tory of trauma other than the tooth extractions Table 8-4 Physical Examination
previously mentioned.
General inspection
Head and neck inspection
A review of systems screens the persons present
Stomatognathic examination
state of health. It includes asking about any recent
Cervical spine examination
symptoms related to the head and neck; the skin; and
Myofascial examination
the cardiovascular, respiratory, gastrointestinal, geni-
Cranial nerve examination
tourinary, endocrine, neurologic, obstetric-gynecolog-
Neurologic screening examination
ic, and musculoskeletal systems.
and dorsal joint capsules for tenderness. The normal Table 8-5 Cranial Nerve Examination
range of jaw opening is 40 to 60 mm. Laterotrusive and
I. Olfactory
protrusive movements should be 8 to 10 mm. The path
Test sense of smell of each nostril separately
of opening and laterotrusive and protrusive move-
by using soap, tobacco, or coffee with
ments should be straight, without deflections or devia-
patients eyes closed
tions. Joint capsule palpation anterior to the tragus of
the ear for the lateral capsule and from the external II. Optic
auditory meatus for the dorsal capsule may be uncom- Test visual acuity
fortable but should not be painful. Examing fundi ophthalmoscopically
As discussed later in the chapter, the cervical spine is Test visual fields
often the source of persistent referred pain to the orofa- III, IV, VI. Oculomotor, Trochlear, Abducens
cial and TMJ regions. Similarly, poor posture is one of Test pupillary reactions to light and
the most important contributing factors to TMJ dys- accommodation
function and myofascial TrP pain. For these reasons, the Test extraocular movements
cervical spine and posture must be evaluated in any Check for ptosis or nystagmus
chronic head and neck or facial pain problem. V. Trigeminal
Examination of the cervical spine includes testing its Motor Palpate masseter and temporalis
range and quality of motion as a whole, as well as testing during contraction
the range and quality of motion of the first two cervical Sensory Test discrimination of
joints individually.5759 Posture, especially anterior head pinprick, V1, V2, V3
positioning, must also be systematically evaluated. For temperature, V1, V2, V3
details on how and why this is important, the reader is and light touch, V1, V2, V3
referred to Travell and Simons Trigger Point Manual.55 Test corneal reflex
Myofascial TrP examination requires a thorough, VII. Facial
systematic palpation of all of the masticatory and cer- Observe patients face during rest and
vical muscles, looking for tight muscle bands and the conversation
focal tenderness associated with myofascial TrPs. Check for symmetry, tics
Myofascial TrP is the most prevalent cause of chronic Examine for symmetric smile, ability to
pain, both in the head and neck region and in gener- wrinkle forehead, hold air in cheeks, and
al.6064 Also, it is frequently an accompanying diagno- tense the platysma muscle
sis to other chronic pain conditions.
VIII. Acoustic
A cranial nerve examination (Table 8-5) is indicated
Whisper, rub fingers or hold watch next to
when the history points to a neuropathic type of pain;
ear, use tuning fork for Rinne & Weber tests
if disturbances in touch, taste, smell, sight, hearing,
motor function, balance, or coordination are suspect- IX, X. Glossopharyngeal, Vagus
ed; or if there are any subjective complaints or objective Check for symmetric movement of soft
signs of cranial nerve involvement. Lesions of the cra- palate and uvula when patient says Ah
nial nerve nuclei or their efferent or afferent pathways Check gag reflex by touching back of throat
will result in an abnormal examination. For example, Note any horseness
meningitis may cause double vision; an acoustic neuro- XI. Spinal accessory
ma may cause hearing loss. Symptoms of numbness or Have patient shrug shoulders against
tingling may accompany nasopharyngeal carcinoma or resistance (trapezius) (partially inervated
other intracranial pathema. Sensory deficits can be ver- by C4)
ified using accurate two-point discrimination testing, Have patient turn head against resistance (SCM)
pinprick tests, and light touch tests. Complaints of XII. Hypoglossal
transient or persistent paralysis, weakness, or spasticity Observe tongue in mouth: check for atrophy or
of any of the head and neck muscles dictate the need asymmetry
for evaluation of the nerves that control their motor Check for deviation by having patient stick
function. tongue out
The motor function of the head and neck is mediat-
ed through several cranial nerves. The trigeminal
nerve, cranial nerve V, controls the masticatory mus-
cles. The facial nerve, cranial nerve VII, controls the These are very often difficult to diagnose and include
muscles of facial expression. The hypoglossal nerve, pathologic conditions such as the tight, pressing pain of
cranial nerve XII, controls the tongue. The spinal coronary artery disease that may be felt in the sternum
accessory nerve, cranial nerve XI, controls the trapez- and the jaws.
ius and sternocleidomastoid muscles. Detailed infor-
mation on how to perform a cranial nerve examination This patient demonstrates swelling and tem-
is available in Batess textbook on physical examination perature change as well as cutaneous hyperesthe-
and history taking.65 If intracranial pathosis is suspect- sia over the painful area. She could still have a
ed, a complete neurologic examination, including chronic osteomyelitis despite the previous course
mental status; cerebellar, motor, and sensory function; of antibiotics. She could have a retropharyngeal
and reflexes, is indicated. This requires referral to a abscess or neoplastic disease affecting or sur-
competent neurologist. rounding the fifth cranial nerve, either intracra-
nially or extracranially. She could also have a
General inspection of the patient reveals an localized coccal infection since she lives in a rural
obese female in moderate distress. Closer inspec- area. The limited range of motion of the left tem-
tion of the head and neck reveals slight swelling of poromandibular joint and the fact that much of
the left cheek with a distinct increase in skin tem- her pain seems to emanate from there bring up the
perature over this site. possibility of severe degenerative joint disease or
On intraoral examination, the intraoral tissues neoplastic disease involving the joint. The myofas-
are firm, pink, and stippled without lesions. The cial TrPs in the left trapezius have probably devel-
patient is missing teeth #15, 16, 17, 18, and 19. oped in response to the chronic pain problem. It is
Temporomandibular joint examination reveals unlikely that myofascial TrP pain is the primary
an active oral opening of only 33 mm with little cause of this patients pain.
translation of the left condyle (the jaw deflects to
the left with opening). Definitive intraoral or The next step involves choosing appropriate diag-
extraoral palpation is impossible because the nostic studies to help rule out the pathema suspected.
patient complains of pain at the slightest touch.
The patient has full range of motion of the Diagnostic Studies
cervical spine. The first two cervical joints simi- Table 8-6 is a list of some of the more common diag-
larly show good range and quality of motion. Her nostic studies available to help facilitate diagnosis.
posture is slightly abnormal, with elevation of the
left shoulder and a forward head position. Panoramic and periradicular radiographs reveal
Myofascial TrP examination is restricted to the an area of bony sclerosis in the mandibular extrac-
cervical muscles and unaffected side owing to the tion sites, consistent with the history of curettage of
extreme sensitivity of the left side of the face. Even dry sockets and not at all typical of osteomyelitis.
so, active myofascial TrPs are found in the left Temporomandibular joint tomograms reveal flat-
upper trapezius that intensify the patients pain tening of the left condyle consistent with mild to
over the left temple and angle of the jaw. moderate degenerative joint disease. Computed
Cranial nerve examination is normal except tomographic (CT) scans of the brain, mandible, and
for the extreme cutaneous sensitivity on the left retropharyngeal area are normal. A gallium scan,
side of the face. Neurologic examination is simi- which is used to identify soft tissue inflammation, is
larly unremarkable. normal also. Skin tests for coccal infection are nega-
tive. Complete blood count and erythrocyte sedi-
At this stage, one must still rule out acute patholog- mentation rate also fail to show any signs of infec-
ic change. Pathosis of the various organs and structures tion or inflammation. No pathosis of the extracra-
of the head and neck should always be suspected first in nial and intracranial structures can be identified.
any orofacial pain. The teeth, pulp and periodontium,
TMJs, eyes, ears, nose, throat, sinuses, and salivary What, then, could be causing this patients pain? At
glands should be thoroughly evaluated (see Table 8-7). this point in the workup of a pain patient, practitioners
As mentioned previously, the quality of pain from this are often tempted to ascribe the pain to some psy-
group varies depending on the etiology. Equally impor- chogenic problem. Clearly, if there is no obvious patho-
tant are many referred pain problems (see Table 8-8). logic process, and the patient is in severe distress or does
Table 8-6 Common Diagnostic Studies the human nervous system and is not an indication of
the mental state of the patient.
Pulp testing
Conversion Reaction. A true conversion reaction
Radiography
is very rare. It is thought to represent the successful
Tomography
substitution of a more valid somatic symptom for
Laboratory studies (blood, urine)
emotional turmoil in a patients life. This symptom is
CT or MRI scan
most frequently blindness or deafness, and the condi-
Bone scan
tion is more common in young women.67 However,
Gallium scan
patients can be of any age or sex, and, occasionally, the
Arthrography
symptom substitution may involve pain. When this
Thermography
occurs, the quality of the pain can be related in very
Nerve conduction studies
descriptive, affective terms such as lightning-like
EEG
explosions,heavy weight pressing on my head,spike
Lumbar puncture
into my head, rope choking my throat, ugly pain,
Differential diagnostic analgesic blocking
and others.
The pain is usually described as continuous or unre-
lenting. It is rarely affected by external events; however,
not respond well to treatments, then she must be suffer- it can be changed by emotions. Despite the elaborate
ing from a psychogenic pain. Dont be too sure! terms used to describe the pain, these patients often
appear indifferent about it.
Psychogenic Pain Clinically, there are usually no physical findings,
Many clinicians use the term psychogenic to refer to including no myofascial TrPs. A careful history may
patients with a chronic pain problem that has a strong reveal that patients either grew up with a parent or rel-
emotional component or to patients who do not ative who was ill or they themselves had a history of a
respond well to somatic treatment. It must be re- prolonged childhood illness. Mental status may be nor-
emphasized, however, that psychological factors are mal; however, these patients generally have been and
intimately involved in the expression of all pain, are under intense emotional stress, have poor social
regardless of etiology or time course. relationships, and may be occupationally incapacitated.
By definition, chronic pain has been present for a The reasons for a conversion reaction vary. Causes
protracted period (at least 6 months), and the patient may include handling nonspecific stress, anticipating a
has usually received multiple treatments with little or major life change, dealing with a catastrophic life situ-
no results. This creates an emotional strain for the ation, and the manifestation of a severe body image
patient and frustration for the clinician, sometimes problem. The patient subconsciously converts an
resulting in the inappropriate label of psychogenic apparently socially unacceptable psychological illness
pain. Patients with chronic pain invariably have a to the socially acceptable physical complaint of pain.
somatic diagnosis. What frustrates the clinician is often Somatic Delusions. Somatic delusions may occur
the discrepancy between the identifiable somatic cause in patients with psychiatric diagnoses such as psychosis
and the disproportionate amount of perceived pain or schizophrenia. These patients lose rational thought
and disability that accompanies this cause. and attachment to reality and display uncontrolled
True psychogenic pain is a rare diagnosis that must obsessions of pain or problems with their health.
be restricted to those patients in whom thorough, Psychiatric care or hospitalization is strongly indicated
sophisticated medical evaluations and tests fail to since the possibility of suicide may be great.
uncover any somatic basis for their pain and in whom Operant Pain (Pain Behavior). Although pain
psychological evaluation reveals psychopathology that behaviors (the behavioral manifestations of pain, dis-
may actually account for their presentation. Myofascial tress, and suffering) likely result from a complex inter-
TrP pain is frequently overlooked as an organic finding action of various psychological and physical factors,40
and is thus often mislabeled as psychogenic pain.66 understanding the basic concepts of learning and
Occasionally, there are patients in whom no etiology operant conditioning is essential to understanding
for their pain can be identified and who have no psy- the chronic pain patient.
chological findings consistent with a psychological dis- In combination with cognitive and affective factors,
order. This situation simply speaks to the limitations of learned behavior and operant conditioning are pow-
our current medical knowledge and the complexity of erful psychological or psychogenic factors that play
an important role in any patient with a chronic or per- ing characterized by habitual presentation for hospital
sistent pain problem. Fordyce and Steger described treatment of an apparent acute illness with a plausible
operant pain and conditioning as follows: and dramatic but fictitious history),1 are also usually
inappropriate. The astute clinician will try to ascertain
in chronic pain, the normal responses to a nox- which environmental factors are acting to maintain
ious stimulus, such as moaning, complaining, gri- and reinforce a particular behavior instead of assuming
macing, limping, asking for medication, or staying that the patient has a character disorder.
in bed, are present for a long enough period of It is important to realize that, whether or not the
time to allow learning to occur. By using the above pain has an ongoing organic basis, it is still very real to
set of actions, termed operants, the patient either the patient and can be as intense as any somatic pain.
purposely or unintentionally communicates to Management typically requires a multidisciplinary
those around him that he has pain. The signifi- approach that includes identification and elimination
cance of these operants is that they can be influ- of any positive reinforcers to the pain behaviors. All
enced by certain consequences. For example, if a treatment and follow-up visits, medications, exercises,
certain behavior or action is consistently followed rest, etc must be scheduled on a time-contingent and
by a favorable consequence (a positive reinforcer), NOT a pain-contingent basis, regardless of the somatic
then the probability that the behavior or action diagnosis. The family must also be educated to rein-
will be repeated again in response to a similar force well behaviors and ignore sick behaviors. Then
stimulus is increased (as in Pavlovs dog). If, how- activity levels must be increased and medications grad-
ever, a certain behavior or action is not consistent- ually decreased and eliminated. The help of a behav-
ly followed by a favorable consequence, the behav- iorally oriented psychologist or psychiatrist familiar
ior will diminish in frequency and disappear. This with chronic pain patients is highly recommended.
is known as extinction.68,69 Occasionally, situational insight, supportive therapy,
guidance, or counseling is sufficient to resolve the
It is generally accepted that all chronic pain begins at problem. Other cases may require more long-term out-
some point with a true pathologic or nociceptive stim- patient psychotherapy. Sometimes medications such as
ulus. This stimulus elicits a pain response or pain antidepressants, antipsychotics, hypnotics, or tranquil-
behavior. Most people live in an environment that sys- izers will help alleviate the pain. Inpatient psychiatric
tematically and positively reinforces pain behaviors care is indicated for anyone at risk of committing sui-
while ignoring or punishing healthy behaviors.69 In cide or inflicting bodily injury on themselves or others.
acute pain, these behaviors and their rewards subside
quickly, but in chronic or persistent pain, pain behav- An interview with a psychologist and the
iors become more prominent and may persist even MMPI did not reveal a psychopathologic state in
after the noxious stimulus is gone: The degree of pain this particular patient. So, clearly, there must be
behavior has little or no direct relationship to patho- other factors that have not been considered that
genic [or nociceptive] factors.69 are causing this patients pain.
It is easy to label the behavioral manifestations of
pain, distress, and suffering as pain of psychogenic ori- Instead of falling into the trap of calling unidentified
gin. Unfortunately, this term usually implies some kind pain psychogenic, one should go back to the classifi-
of personality disorder such as hypochondriasis cation of pain (see Table 8-2) to answer this question.
(excessive concern with ones health and bodily func- Based on the burning quality of pain, it is clear that
tions) or hysteria (also known as conversion reaction), neuropathic or sympathetic pains would be the cate-
and often this is not present, or, if it is, it generally has gories most likely to carry a diagnosis that accounts for
little or nothing to do with the pain. As Fordyce said, It this patients pain. These pains and specific diagnoses
is not necessary to have personality problems to learn a within each category are described in more detail later
pain habit, because learning occurs automatically if the in the chapter.
conditions are favorable.69 Therefore, other psycho-
logical labels, such as somatization (conversion of SPECIFICS FOR EACH BROAD CATEGORY
mental states into bodily symptoms similar to hysteria OF PAIN ORIGIN
but with more elaborate complaints), malingering The remainder of the chapter will be devoted to dis-
(conscious exhibition of pain or illness for secondary cussing many of the specific diagnoses that fall into
gain), and Munchausen syndrome (a type of malinger- each broad diagnostic category. This classification is by
no means exhaustive. The disorders discussed are those Table 8-8 Referred Pain from Remote Pathologic
with which dentists should be familiar. An exhaustive Sites
treatise of orofacial pains has been published by Bell70
Structures Diseases
and an official classification with diagnostic criteria by
the International Headache Society.54 Heart Angina pectoris, myocardial infarction
Thyroid Inflammation
Extracranial Pathosis Carotid artery Inflammation, other obscure causation
Local pathosis of extracranial structures and referred Cervical spine Inflammation, trauma, dysfunction
pain from remote pathologic sites are listed in Tables Muscles Myofascial trigger points
8-7 and 8-8.
Acute pain arising from pathosis of the extracranial
structures is commonly seen in dental practice. Some
extracranial acute pain is well localized, easily identifi- Symptoms. Salivary gland pain is typically localized
able, and straightforward to treat. However, some pains to the gland itself, and the gland is tender to palpation.
from local pathema are more elusive because they are Precipitating and aggravating factors to the pain are
referred to other head and neck structures. Similarly, salivary production prior to meals, eating, and swallow-
pathosis of some distant structures such as the heart ing. Mouth opening may aggravate the pain because of
and thyroid may refer pain into the head, neck, or jaws. pressure on the gland from the posterior border of the
These more unusual pains will be discussed. mandible during this movement. This, and increased
Tooth Pulp, Periodontium, Periradicular Structures, pain with chewing, may lead the clinician to mistake the
Gingiva, Mucosa. Diseases of the intraoral structures, pain as being from the masticatory system. Associated
including referred pain from pulpalgia, are fully dis- symptoms include salivary gland swelling and, occa-
cussed in chapter 7 and will not be covered here. sionally, fever and malaise. Salivary flow from the affect-
Salivary Gland Disorders. The salivary glands can ed gland may be minimal or nonexistent.
be affected by many diseases, including ductal obstruc- Examination. The pain can be localized fairly well
tion, infection, inflammation, cystic degeneration, and by palpation. Other signs of inflammation may be pres-
tumor growth. Pain and tenderness are typically found ent. With parotid gland disorders, to determine dimin-
in association with ductal obstruction, inflammation, ished or absent flow, the gland can be manually milked
or infection. while observing salivary flow from the parotid duct.
Etiology. The most common causes are mumps Diagnostic Tests. Radiographs of the gland and
and acute parotitis in children and blockage of salivary ducts may reveal a calcific mass in the region of the
flow by a mucus plug or a sialolith in adults. The latter gland. Sialography (radiographic examination of a
results in pressure from salivary retention and may gland using a radiopaque dye injected into the ductal
cause ascending infection. Sjgrens syndrome, a dis- system) may also show obstruction or abnormal ductal
ease of unknown etiology typically seen in older patterns.
women, is characterized by dry eyes, dry oropharyngeal Treatment. The mucus plug or sialolith should be
mucosa, and enlargement of the parotid glands.71 This removed in the case of obstruction. Antibiotics may be
disorder also may cause salivary gland pain if the needed if infection accompanies the pain.
glands become inflamed. Ear Pain. Most patients who have a primary com-
plaint of ear pain will seek the help of their primary
care physician or an ear, nose, and throat (ENT) spe-
Table 8-7 Local Pathosis of Extracranial Structures cialist. Ear pain is typically seen with disorders such as
otitis media, otitis externa, and mastoiditis and may be
Structures Diseases associated with headache. When a medical workup is
Tooth pulp, periradicular structures Inflammation negative, patients may be referred to the dentist for
Periodontium, gingival, mucosa Infection evaluation of ear pain. Astute physicians will want to
Salivary glands Degeneration know whether the TMJ or the pulpalgia is referring the
Tongue Neoplasm symptoms. Patients may also present themselves to the
Ears, nose, throat, sinuses Obstruction dentist with another primary pain complaint such as
Eyes toothache or headache, whereupon when taking a care-
Temporomandibular joints ful history, ear pain is found to be an associated symp-
tom. The dentist needs to rule out dental disease or
temporomandibular disorders as a cause of ear pain. of primary ear disease. These TrPs and resulting masti-
Additionally, the dentist must decide when a referral catory dysfunction are self-perpetuating, even after the
for a medical workup of ear pain is indicated. acute ear problem resolves. Appropriate treatment of
Etiology. The ear is innervated by cranial nerves V, this secondary masticatory dysfunction will be
VII, VIII, IX, X, and XI and also branches of the upper required for resolution of the complaint.
cervical roots that supply the immediate adjacent scalp
and muscles. Therefore, pain can be referred to the ear Case History
from inflammatory or neoplastic disease of the teeth, A good example of this phenomenon is a 27-
tonsils, larynx, nasopharynx, thyroid, TMJ, and cervical year-old woman who presented with an 18-month
spine, as well as from inflammation or tumors in the history of right-sided facial pain that started after
posterior fossa of the brain.72 Ear pains are also associ- a middle ear infection. During the initial illness,
ated with neuralgias such as herpes zoster of cranial she experienced dizziness, and a spinal tap was
nerve V or VII, glossopharyngeal neuralgia, and nervus performed to rule out viral meningitis. This was
intermedius neuralgia. These will be discussed later. negative, and a diagnosis of a viral syndrome was
Symptoms. Primary ear pains are usually described made. Several months later, persistent pain led the
as a constant aching pressure. Their onset is usually patient to seek a further ENT consultation. A cyst
recent. Inflammatory or infectious disorders may be discovered in the right maxillary sinus was
associated with fever and malaise. These complaints removed through a Caldwell-Luc procedure, with
should be diagnosed and managed by an ENT specialist. only transient relief of symptoms, however.
Patients with otitis externa (inflammation of the On evaluation, the patient complained of
external auditory canal) may present themselves to the intermittent, deep, dull, aching pain in the right
dentist first because this pain is aggravated by swallow- side of her face, including her eye, ear, and neck.
ing. Otitis externa may be misdiagnosed as arthralgia of The pain was associated with blurred vision, pto-
the TMJ if the condyle is palpated through the external sis, and redness of both eyes. She also complained
auditory canal without first evaluating the ear. of unilateral hearing loss and nasal congestion on
Glossopharyngeal neuralgia, also aggravated by swal- the symptomatic side. The pain occurred one or
lowing, may need to be considered if ear and dental two times per week and lasted 24 to 48 hours.
pathosis are absent. Examination revealed multiple active myofascial
Examination. The dentist must carefully examine TrPs in the right masseter, temporalis, medial ptery-
the dentition for pulpal disease and the oropharyngeal goid, sternocleidomastoid, and suboccipital muscles
mucosa for inflammation to rule out referred ear pain that reproduced all of her symptoms, including
from oral or dental sources. Myofascial TrPs in the lat- blurred vision. In contrast, there were essentially no
eral and medial pterygoid muscles frequently refer pain TrPs in any of the muscles on the asymptomatic side.
to the ear as well. Treatment directed at rehabilitation of the involved
If primary ear pain is suspected, referral to a compe- muscles provided significant reduction in the inten-
tent ENT specialist should be made. However, screen- sity and frequency of her pain.
ing examination should include visual inspection of
the ear and ear canal. Use of an otoscope facilitates this Sinus and Paranasal Pain. The most common
examination. Wiggling the auricle itself or tugging on extraoral source of dental pain arises from the maxil-
the earlobe will aggravate otitis externa and will help lary sinus and associated pain-sensitive nasal mucosa.
distinguish an ear lesion from a TMJ problem. Many teeth have been mistakenly extracted because of
Pumping on the ear with the palm of the hand will an incorrect diagnosis of this syndrome.
exacerbate pain from otitis media. Hearing can be Symptoms. Contrary to popular belief, infection
grossly evaluated by rubbing the fingers together in and inflammation of the sinuses rarely cause facial pain
front of each ear or using a watch tick or coin click. The or headache. Chronic sinusitis may cause symptoms of
practitioner can use his own hearing as a control. fullness or pressure but rarely pain. The location of
Treatment. Primary ear pain should be diagnosed these symptoms may vary from the maxilla and maxil-
and managed by an ENT specialist. Dental sources of lary teeth in maxillary sinusitis to the upper orbit and
ear pain are treated by treating the oral pathema. Of frontal process in frontal sinusitis, between and behind
importance is the fact that primary ear pain may also the eyes in ethmoid sinusitis, and at the junction of the
induce secondary myospasm and development of hard and soft palate, occiput, and mastoid process in
myofascial TrPs, which may persist beyond the course sphenoid sinusitis.
The sinusitis patient who reports to the dentist does rectly refer the patient for complete diagnosis and
so with a chief complaint of toothache. In this case, treatment.
constant but rather mild pain in a number of posterior The extraoral examination should include palpation
maxillary teeth on one side is almost pathognomonic. of the maxillary sinuses under the zygomatic process
All of the teeth on this side, the roots of which are relat- bilaterally. If maxillary sinusitis is present and unilater-
ed to the floor of the sinus, may be aching mildly. al, the cheek on the involved side, from the canine fossa
The teeth feel elongated, as if they touch first when back to the base of the zygomatic process, will be ten-
the patient closes. The teeth are also tender, and the der to heavy palpation. The patient may say it feels as if
patient clenches against them, saying it hurts good to he has been hit in the area, or frostbitten is another
do so. These same maxillary teeth are hypersensitive to term used in northern climes. It may also hurt to smile.
cold fluids. Occasionally, all of the maxillary teeth on If the patient complains of frontal headache, the
the involved side, to the midline, feel uncomfortable dentist should check the frontal sinuses for tenderness
and elongated. The pain, mild but deep and nonpulsat- by pressing up against the inferior surface of the supra-
ing, radiates out of this area onto the face, upward orbital ridge on each side of the nose. All of the anteri-
toward the temple, and forward toward the nose. A or sinuses, maxillary, frontal, and anterior ethmoidal,
referred frontal headache and cutaneous hyperalgesia may be involved at one time. Such pansinusitis may fol-
along the side of the face and scalp may also be present. low an upper respiratory infection.
The patient frequently reports that the pain begins in The intraoral examination should include mobility,
the early afternoon or may give a history of increased percussion, thermal and electric pulp tests, and radi-
pain at altitude when crossing a high mountain pass or ographs. The teeth adjacent to the affected maxillary
when making a plane flight. Patients may also complain sinus often are mobile when moved between the two
of a stuffy nose, blood- or pus-tinged mucus, post-
nasal drip, fever, and malaise.
Etiology. The sinuses themselves are relatively
pain-insensitive structures. Studies done by both Wolff
and Reynolds et al. demonstrate that most so-called
sinus pain actually arises from the nasal mucosa or
from stimulation of the nasal ostia.73,74 Nasal spurs
have also been implicated as a cause of facial pain or
headache.75 The nasal mucosa and the pain-sensitive
ostia become irritated and inflamed when inflammato-
ry exudate from the antrum spills out onto these struc-
tures.76 Direct stimulation of the ostia has also been
shown to refer pain to the teeth.76,77
Allergies may also cause boggy, edematous nasal
mucosa. This may cause swelling of the turbinates,
which may, in turn, block off the ostia of the maxillary
sinuses. This has been implicated in causing referred
symptoms to the teeth (Figure 8-14).
Sicher also pointed out that the superior alveolar
nerves, supplying the maxillary molar and premolar
teeth, pass along the thin wall of the sinuses.78 The
canaliculi of the teeth often open toward the sinus, and
pulpal nerves may be in direct contact with the
inflamed mucoperiosteum of the sinus lining. Their
direct irritation may cause dental symptoms. The
reverse is also true. Inflammation or infection from the
root of a tooth in contact with the sinus floor may
cause sinusitis. This, in turn, will not resolve until the
Figure 8-14 Inflammation of nasal mucosa causes swelling of the
dental problem is corrected. turbinate and blocks off the ostium of the maxillary sinus. Pain
Examination. The dentists contribution will be to referred to maxillary teeth may then develop. Reproduced with per-
rule out dental disease as the cause of the pain and cor- mission from Ballenger JJ.77
index fingers. Furthermore, the teeth are painful and Historically, there has been much confusion around
sound mushy when percussed and may be hypersen- TMD and the differential contribution of pain from
sitive to cold or when pulp tested electrically compared the joint versus the muscles and MFP. In a study con-
to the uninvolved side. Illuminating the sinuses with a ducted at the University of Minnesota TMJ and Facial
fiber optic in a darkened room may reveal changes in Pain Clinic, doctors evaluated 296 consecutive patients
the affected sinus. Direct inspection of the nasal pas- with chronic head and neck pain complaints.66 Only
sages with a speculum will reveal engorged nasal 21% of these patients had a TMJ disorder as the pri-
mucosa and turbinates. mary cause of pain. In all 21%, the joint disorder
Radiographically, the involved teeth are likely to be included an inflammation of the TMJ capsule or the
normal, reconfirming that nothing is wrong orally. The retrodiscal tissues. Myofascial pain owing to TrPs was
roots of the teeth, however, may be found extending the primary diagnosis in 55.4% of the patients in the
well up into or against the sinus floor, which would Minnesota study, almost three times the incidence of
account for their involvement. On the other hand, the primary joint pain. Nonpainful internal derangements
radiograph and pulp test may show a pulpless tooth of the TMJs were felt to be a perpetuating factor to the
with a periradicular lesion. As stated previously, this myofascial TrPs in 30.4%.60
could be the cause of a unilateral sinus inflammation. Considering these data, it is important to make a
Nenzen and Walander found local hyperplasia of the distinction between true TMJ pain, MFP owing to TrPs
maxillary sinus mucosa in 58% (14 of 24) of the alone, and MFP owing to TrPs that is being perpetuat-
ed by a noninflammatory or intermittently inflamma-
patients who had pulpless teeth with periradicular
tory joint condition. Treatment priorities will be affect-
lesions associated with the floor of the sinus.79
ed accordingly.
Persistent pain in this area may be caused by a cyst
Table 8-9 provides a simple breakdown of TMJ dis-
or neoplasm of the maxillary sinus. In these cases, the
orders, the vast majority of which are nonpainful.
pain syndrome is the same as for sinusitis but more
Included in this category are inflammatory disorders,
long-standing. A radiographic study of the area may
disk derangement disorders, and osteoarthritis. It is
reveal the lesion.
possible to have several of these diagnoses affecting one
The diagnosis of maxillary sinusitis may be con- joint. It is also very common to find myofascial TrP
firmed by spraying 4% lidocaine anesthetic from a pain associated with TMJ pathosis.
spray bottle into the nostril on the affected side. This
will anesthetize the sensitive area around the ostium.
The pain from the congested nasal mucosa and accom-
panying maxillary sinusitis should be substantially Table 8-9 Temporomandibular Joint Articular
reduced within a minute or two. Disorders
Treatment. Complete diagnosis and treatment of
maxillary sinusitis are left to the ENT specialist. Inflammatory disorders
Treatment usually consists of the use of decongestants Capsulitis/synovitis
and analgesics. If there is persistent purulent dis- Polyarthritides
charge, cultures should be taken and appropriate Disk derangement disorders
antibiotics prescribed. Disk displacement with reduction
Temporomandibular Joint Articular Disorders. Disk displacement without reduction
Before discussing TMJ disorders, a distinction must be Osteoarthritis (noninflammatory disorders)
Primary
made between pain and dysfunction arising from the
Secondary
TMJ itself, temporomandibular disorder (TMD), and
Congenital or developmental disorders
MFP owing to trigger points. Temporomandibular dis-
Aplasia
order is an umbrella term that refers to various painful
Hypoplasia
and nonpainful conditions involving the TMJ and the
Hyperplasia
associated masticatory musculature. Myofascial pain is
Neoplasia
a distinct muscle pain disorder that produces various
Temporomandibular joint dislocation
local and referred symptoms from TrPs in taut bands of
Ankylosis
skeletal muscle and may or may not be associated with Fracture (condylar process)
a TMJ disorder. Myofascial pain is reviewed in detail
later in this chapter. Adapted from Okeson.61
The term internal derangement applies to all joints with mandibular function, crepitus, and a limited
and encompasses those disorders causing mechanical range of motion.
interference to normal joint function. In the TMJs, this Etiology. Inflammation of the capsule or synovi-
primarily involves displacement and distortion of the um may occur secondary to localized trauma or infec-
articular disk, as well as remodeling of the articular tion, through overuse of the joint, or secondary to
surfaces, and joint hypermobility.80 Many of the artic- other joint disorders. Synovitis may also occur second-
ular disorders affecting the TMJs involve an abnormal ary to primary osteoarthritis. The inflammatory condi-
or restricted range of motion and noise but are rela- tions occur most commonly in young people with a
tively painless. These include the congenital or devel- history of trauma, clenching, bruxism, or internal
opmental disorders, disk derangement disorders, derangement.84
osteoarthritis, and ankylosis listed in Table 8-9. Any Inflammation and degenerative changes in the TMJ
pain associated with these disorders is usually momen- caused by systemic rheumatologic illnesses that affect
tary and associated with pulling or stretching of liga- multiple joints are called polyarthritides. They include
ments. In the case of ankylosis, pain ensues if the most commonly rheumatoid arthritis, juvenile
mandible is forcibly opened beyond adhesive restric- rheumatoid arthritis, psoriatic arthritis, and gout. The
tions. Forcible opening can cause acute inflammation. autoimmune disorders and mixed connective tissue
Primary or secondary osteoarthritis, unless accompa- diseases such as scleroderma, Sjgrens syndrome, and
nied by synovitis, is also associated with minimal pain lupus erythematosus may also affect the TMJ.61
or dysfunction,61 although crepitus and limited range Examination. For capsulitis and synovitis, palpa-
of motion may be present. tion over the joint itself is painful. Posterior or supe-
As far as the incidence of TMJ pain in the general rior joint loading and any movement that stretches
population is concerned, the National Institute of the capsule may also increase the pain. Range of
Dental Research, reporting on the National Center for motion is not usually restricted except owing to pain.
Health Statistics 1989 survey of 45,711 US households Initiation of mandibular movement after a period of
over 6 months, has estimated that 9,945,000 Americans rest may be slow and sticky. Inflammatory effusion
were suffering from what they termed jaw joint pain. in the joint may cause acute malocclusion with slight
They further estimated that 5.3% of the US population disclusion of the homolateral posterior teeth.
were experiencing this condition at any one time. Twice Although clenching may be painful, biting on a
as many women as men complained of jaw pain.81 tongue depressor may reduce the pain by preventing
Inflammatory Disorders of the Joint. It is the intercuspation and full closure.
inflammatory joint disorders that cause pain. Included In the polyarthritides, palpation of the joint is also
in this group are capsulitis and synovitis and poly- painful. Range of motion is not affected except owing
arthritides (Table 8-9).82,83 to pain and may be accompanied by crepitus; maloc-
Symptoms. Capsulitis and synovitis present with clusion is related to inflammatory effusion or lateral
similar signs and symptoms and are difficult to differ- pterygoid muscle spasm secondary to the primary
entiate. The chief symptom is continuous pain over the pain.83 In severe cases of rheumatoid arthritis, rapid
joint, aggravated by function. Swelling may be evident, resorption of the condyles causes an acute anterior
and the patient may complain of an acute malocclusion open bite.61 Ankylosis may also occur.
(back teeth on the same side dont touch), restricted Diagnostic Tests. Plain films and tomography will
jaw opening, and ear pain. There is usually a history of show few, if any, bony changes in the joint with cap-
trauma, infection, polyarthralgia, or chronic, non- sulitis or synovitis unless these are secondary to
painful degenerative arthritis that is now in an acute osteoarthritis. Magnetic resonance imaging, on the
stage.61,83 Because the pain is fairly constant, the clini- other hand, will show a bright T2-weighted signal sec-
cal picture is often complicated by referred pain, mas- ondary to the presence of fluid.
ticatory muscle spasm, or myofascial TrP pain.83 The The polyarthritides will show extensive TMJ
pain tends to wax and wane with the course of the changes on radiographic examination. Radiographic
inflammation. Inflammatory disorders of the joint may changes include more gross deformities than are seen
occur alone or in combination with an internal in osteoarthritis, including erosions, marginal prolifer-
derangement. ations, and flattening. Of particular diagnostic value in
Polyarthritides are relatively uncommon and occur the polyarthritides are various serologic tests screening
with other rheumatologic diseases, such as rheuma- for evidence of rheumatoid disease such as antinuclear
toid arthritis. Symptoms may include pain at rest and antibodies, elevated erythrocyte sedimentation rate,
rheumatoid factor, or anemia, although not all when present, is intermittent and related to interfer-
rheumatologic diseases are seropositive. Definitive ence or jamming of the disk and function of the
diagnosis and management of the polyarthritides are condyle against ligaments. Patients may complain of
left to the rheumatologist. The dentists role is to man- difficulty in opening the jaws, particularly in the morn-
age concomitant TMJ symptoms should they occur. ing. Sometimes they have to manipulate their jaws,
Treatment. In treating inflammatory TMJ disor- with a resultant loud crack, before they can function
ders, palliative care is an appropriate first step. This normally for the rest of the day.
includes jaw rest, a soft diet, and nonsteroidal anti- Patients who present with disk displacement without
inflammatory drugs (NSAIDs). Intermittent applica- reduction usually relate a history of TMJ clicking that
tion of ice or moist heat may also be helpful. Office stopped when the joint locked. In addition to the lim-
physical therapy, including ultrasonography, may be ited range of motion, they may also complain of mild
indicated in some patients. Single supracapsular or hyperocclusion on the affected side. Acutely, there may
intra-articular injections of steroids may be effective in be pain that is usually secondary to attempts to open
reducing inflammation and pain if simpler methods the mouth. Over time, the mandibular range of motion
prove ineffective. Pain relief from steroid injection can gradually improves and the pain subsides, often being
be expected to last 112 to 2 years provided that the replaced with a feeling of stiffness.
patient limits joint use appropriately. It is generally Etiology. The development of a disk displacement
accepted that steroid injections into the TMJ should be disorder is often attributed to external trauma, such as
limited: no more than two in 12 months, and two or a blow, or to chronic microtrauma, such as habitual
three in a lifetime. This is because of concern about parafunction (especially bruxism) in a TMJ in which
inducing joint deterioration owing to the steroid.85 structural or functional incompatibilities exist.
More recent data suggest that these injections may be Occlusal disharmony, such as loss of posterior teeth or
better tolerated than previously thought.86 occlusal interferences in retruded and lateral move-
Definitive therapy is aimed at reducing the causative ments, may contribute to the problem but is rarely
or contributing factors. This must involve the patient, causative.
who alone controls the functional demands placed on Discrete clicks and pops are the result of the rapid
the joint. The dentist must enlist his help and compli- reduction of an anteriorly displaced disk on opening
ance. This is best achieved through reassurance and (Figure 8-15). Locking results when the disk is so
education. The patient must be motivated to reduce severely displaced or deformed that it can no longer
joint use and eliminate abusive habits. Home exercises, relocate itself on top of the condyle during normal
application of heat and ice, and massage are also opening movements (Figure 8-16).
important. In addition to the self-help program, con- Examination. With disk displacement with reduc-
struction of a stabilization splint may help reduce tion, there is a normal mandibular range of movement.
bruxism and decrease intra-articular pressure on the Palpation of the joint on opening and closing will
joint. If necessary, a psychological approach to decrease reveal a fairly distinct click or pop that is often accom-
bruxism or clenching may also be instituted. Surgery is panied by a slight deviation of mandibular movement.
seldom, if ever, indicated. These clicks and pops are usually found at approxi-
If the condition is owing to polyarthritis, manage- mately 25 to 30 mm of opening, the point at which the
ment is similar to treating the systemic disease itself. It condyle shifts from rotation to translation in the open-
includes analgesics and anti-inflammatory agents such ing cycle. Often these joint noises are reciprocal. That
as aspirin, indomethacin, ibuprofen, corticosteroids is, there is another, very soft click just at the end of the
such as prednisone, gold salts, and penicillamine. closing path. It is at this time that the disk once again
Physical therapy, home exercises, appropriate jaw use, slips off the condyle and into its anterior position.
reduction of abusive habits, occlusal stabilization, and With disk displacement without reduction, there is
periodic intra-articular steroid injections are other clear restriction of jaw range of motion to approxi-
supportive measures. Surgical intervention is limited to mately 25 to 30 mm. If only one joint is locking, the
severe cases with marked dysfunction. midline will deviate toward the affected joint. Forced
Disk Derangement Disorders. The disk derange- opening results in pain. Laterotrusive movement is
ment disorders include disk displacement with and restricted to the unaffected side; bilateral restriction
without reduction. exists if the disorder affects both joints.
Symptoms. Both of these disorders are typically Diagnostic Tests. For both disk displacement with
painless. With disk displacement with reduction, pain, and without reduction, tomograms of the joints may
Figure 8-15 Internal temporomandibular joint derangement Figure 8-16 Severe disk derangementthe closed lock situation.
the early click. Notice in the closed position (A) that the disk In the closed projection (A), notice that the stippled disk has been
(stippled) is situated completely anterior to the articulating sur- deformed from a normal biconcave wafer to an amorphous mass.
face of the condyle. As the condyle begins to translate anteriorly, The disk is situated entirely anterior to the condylar articulating
it passes beneath the thickened rim of the disk at the same time surface. During jaw opening (B and C), the condyle progressively
the patient notices a click within the joint. At one fingerbreadth forces the disk mass anteriorly, causing greater deformation. At no
opening (B), and throughout the remaining opening sequence point in the sequence does the condyle negotiate its way past the
(C and D), the relationship between the disk and bony structure thickened posterior aspect of the disk to acquire a normal relation-
is normal and not painful. Reproduced with permission from ship. Locking (D) and discomfort ensue. Reproduced with permis-
Wilkes CH. Arthrography of the temporomandibular joint. Minn sion from Wilkes CH. Arthrography of the temporomandibular
Med 1978;61:645. joint. Minn Med 1978;61:645.
reveal a mild posterior displacement of the condyle in occlusal rehabilitation or surgery should be avoided
the glenoid fossa, although this is not a consistent find- except in carefully selected cases.91
ing and should not be used alone to make a diagnosis. Osteoarthritis (noninflammatory) is found in many
Bony contour of the condyle will usually show only of the joints of the body and is classified according to
mild degenerative changes. Arthrography or MRI perceived etiology. Primary osteoarthritis is so called
reveals anterior displacement of the articular disk in because its etiology is unrelated to any other currently
both conditions. In disk displacement with reduction, identifiable local or systemic disorder.92 It may affect
the anterior displacement typically normalizes during the TMJ alone or may include other joints of the
jaw function. body.90,93,94 When other joints are involved, any of the
Treatment. Because most disk displacement disor- weight-bearing joints in the body may be affected.
ders are nonpainful, many patients only require an Heberdens nodes of the terminal phalangeal joints are
explanation for their symptoms and reassurance. There a clinical feature.
is no clear evidence that all disk displacement disorders Secondary osteoarthritis, on the other hand, is con-
are progressive87 or that intervention prevents progres- sidered to be the result of a specific precipitating event
sion. In fact, most TMDs are self-limiting.8890 (such as trauma or infection) or other disease or disor-
Specific treatment, when indicated, will depend on der (such as rheumatoid arthritis, endocrine distur-
the specific nature of the derangement. Conservative, bance or gout, or a TMJ disk derangement disorder).
reversible treatments such as patient education and Symptoms. Despite their classification as nonin-
self-care, physical therapy, behavior modification, flammatory disorders, primary and secondary
orthopedic appliances, and medications are appropri- osteoarthritis may be associated with a secondary syn-
ate. Since most TMDs are self-limiting and resolve ovitis. As a result, the patient may complain of pain
without serious long-term effects,8190 extensive with function and tenderness over the joint. In the
absence of synovitis, crepitus and limited range of underlying cause may facilitate resolution of any symp-
motion are the most likely complaints. toms associated with the osteoarthritis.
Etiology. Osteoarthritis is a degenerative joint con- Congenital or developmental disorders such as
dition characterized by joint breakdown involving ero- aplasia, hypoplasia, and hyperplasia tend to cause
sion and attrition of articular tissue along with remod- esthetic and functional problems and are rarely accom-
eling of the underlying subchondral bone95 (Figure 8- panied by pain.
17). Degenerative change is thought to be induced Temporomandibular joint dislocation refers to that
when the joints natural physiologic remodeling capa- situation when a patient is unable to close his mouth
bilities are exceeded owing to factors that overload and because the condyle is trapped either anterior to the
stress the joint.95,96 articular eminence or anterior to a posteriorly dislocat-
Examination. The distinguishing clinical feature of ed disk.97 Elevator muscle spasm usually aggravates the
osteoarthritis is crepitus: grating or multiple cracking situation by forcing the condyle superiorly and oppos-
noises within the joint during opening and closing. There ing attempts to relocate the condyle in the glenoid fossa
may also be limitation of movement of the condyle and or on the articular disk. There is usually a history of
deviation to the affected side with opening. When nonpainful hypermobility and sometimes of previous
accompanied by synovitis, there is pain with function dislocations that the patient was able to reduce himself.
and point tenderness over the joint on palpation. Symptoms. The patient is distressed because of the
Diagnostic Tests. Radiographic examination of the inability to close the mouth and sometimes associated
condyle may reveal decreased joint space, subchondral pain. There is acute malocclusion.
sclerosis, cystic formation, surface erosions, osteo- Examination. This reveals an anterior open bite
phytes, or marginal lipping. The articular eminence with only the posterior teeth in contact. Visual inspec-
may be flattened or eroded or may contain osteophytes tion or palpation of the articular fossa may reveal a
(see Figure 8-15). All clinical laboratory findings are depression where the condyle would normally be.98
usually within normal limits. Diagnostic Tests. Radiographic examination shows
Treatment. Since most osteoarthritis is nonpainful the condyles anterior to the articular eminence or ante-
and dysfunction is minimal, patients often do well with riorly displaced within the fossa.
appropriate explanation of their symptoms and reassur- Treatment. Reduction of the mandibular displace-
ance without specific treatment. When accompanied by ment is the goal and usually requires some kind of man-
synovitis and pain, treatment strategies for the acute ual manipulation of the mandible. Initial steps include
inflammatory disorders are appropriate. Identification reassurance followed by gentle jaw opening against
in secondary osteoarthritis of a precipitating disease or resistance to relax the elevator muscles. Manipulation
event may simplify treatment since correction of the procedures to reduce the mandible range from simple
downward and posterior pressure on the chin during
voluntary yawning, to downward and backward pres-
sure on the mandibular molar teeth during yawning, to
the administration of muscle relaxants or local anes-
thetic or even intravenous sedation followed by manual
manipulation. Patients can expect some mild residual
pain for one to several days following reduction.
Ankylosis in the TMJ refers to a fibrous or bony
union between the condyle, disk, and fossa causing
restricted mandibular range of motion with deflection
of the mandible to the affected side but no pain.
Ankylosis may follow joint inflammation caused by
direct trauma, mandibular fracture, surgery, or a sys-
temic disease such as arthritis. Treatment depends on
the degree of dysfunction: arthroscopy and physical
therapy may improve function for fibrous ankylosis
(most common); open joint surgery is needed to create
Figure 8-17 Degenerative joint changes that occur to the disk and
a new articulating surface in bony ankylosis (relatively
condylar surfaces. Disk perforation (arrow), allowing bone-to-bone
contact, may cause crepitus and pain on opening and closing. rare). Elevator muscle shortening must be addressed as
(Courtesy of Dr. Samuel Higdon.) part of the management protocol for both conditions.
Figure 8-19 A, Dermatome chart of upper extremity of man. Pain referred out of the chest from the first thoracic dermatome advances by
overlapping dermatomes to the third cervical dermatome, which, in turn, overlaps the third division of the fifth cranial nerve. This has been
offered as a possible explanation for reference of deep visceral pain from the myocardium into the jaws and teeth and down the left arm. B,
Detailed map of sensory nerve responsibility. Note how C2 overlaps with V3 (trigeminal-mandibular). A reproduced with permission from
Keegan J, Garrett FD. The segmental distribution of the cutaneous nerves in the limbs of man. Anat Rec 1948;102:409. B reproduced with
permission from Clemente CD. Anatomy: a regional atlas of the human body. Philadelphia: Lea & Febiger; 1975.
Primary afferent nociceptors from both visceral 8-20, A). Accompanying these symptoms may be a
and cutaneous neurons often converge onto the sense of impending doom, nausea, and the attendant
same second-order pain transmission neuron in signs of shock: sweating, cold clammy skin, and a gray
the spinal cord. The brain, having more awareness complexion. In advanced stages, the patient becomes
of cutaneous than of visceral structures through unconscious and cyanotic. If conscious, the patient
past experience, interprets the pain as coming generally complains of the severe pain and rubs the
from the regions subserved by the cutaneous chest, jaw, and arm. These are the advanced signs and
afferent fibers (see Figure 8-6). symptoms of a heart attack.
Severe pain in the left maxilla and mandible related
Hence, branching and/or convergence of thoracic, to angina pectoris or myocardial infarction may occur
cervical, and fifth cranial nerve fibers might well explain without any other symptoms. Bonica reported an inci-
the bizarre pain referral patterns from the heart. dence as high as 18% for the presentation of cardiac
Symptoms. Angina pectoris is typically character- pain as jaw or tooth pain alone.105 The distribution of
ized by heaviness, tightness, or aching pain in the mid this cardiac pain may vary. One patient had the unusu-
or upper sternum. These symptoms may radiate al symptoms of referred pain in the left maxilla and
upward from the epigastrium to the mandiblethe left right arm but no chest pain. Matson reported a case of
more frequently than the right. In addition, the inner coronary thrombosis during which the patient experi-
aspects of the arms may ache, again the left more fre- enced pain in both sides of the mandible and neck,
quently and extensively than the right. This pattern is which radiated to the lateral aspects of the zygoma and
similar to that seen with myocardial infarction (Figure temporal areas. She specifically denied having chest,
8-20, A). Precipitating factors include exertion and shoulder or arm pains106 Norman discussed four
emotional excitement or ingestion of food.103 Angina unusual cases of myocardial infarction with pain
attacks are usually short-lasting, rarely longer than 15 referred to the right and left jaws.107 The left maxilla is
minutes. A number of patients with recurrent angina also a common site. Batchelder and her colleagues103
pectoris, who know they have the disease and who use also reported a case in which mandibular pain was the
nitroglycerine to control the attacks, have reported left sole clinical manifestation of coronary insufficiency.
mandibular pain with each spasm. Anginal pain Krant reported referred pain in the left mandibular
referred to the left posterior teeth was well document- molars that proved to be a manifestation of a malig-
ed by Natkin et al.: In certain instances pain was expe- nant mediastinal lymphoma.108 It is these patients with
rience with concomitant chest pain, and in other jaw pain in the absence of other symptoms of heart dis-
instances, pain was confined to the teeth.104 ease who report to the dental office for diagnosis.
Myocardial infarction is characterized by a symp- Etiology. Angina pectoris refers to pain in the
tom complex that includes a sudden, gradually increas- thoracic region and surrounding areas owing to tran-
ing precordial pain, with an overwhelming feeling of sient and reversible anoxia of the myocardium sec-
suffocation. The squeezing pain radiates in a pattern ondary to exertion or excitement.109 Coronary ather-
similar to that described for angina pectoris (see Figure osclerosis is the most common cause of this anoxia.
A B
Aortic stenosis and coronary arterial spasm are other, fever, asthenia, and malaise.109 Symptoms may wax and
less frequent causes. wane over a period of months and then finally resolve
Myocardial infarction refers to necrosis of the car- with return of normal thyroid function.
diac muscle secondary to a severe reduction in coro- Etiology. Subacute thyroiditis is reported to occur
nary blood supply.109 Coronary artery occlusion may 2 to 3 weeks after an upper respiratory infection and is
develop from gradual closure of the vessel by athero- viral in origin.111
sclerotic deposits on the vessel wall or may be caused by Examination. The thyroid gland may be visibly
hemorrhage under an atherosclerotic plaque, raising enlarged and will be tender to palpation with nodular-
the plaque to obstruct the vessel lumen. Predisposing ity (Figure 8-21). If thyroiditis or other thyroid disease
factors include heredity, obesity, tobacco use, lack of is suspected, referral to the patients physician should
physical exercise, diet, emotional stress, and hostility be made for a complete medical workup.
and anger.110 Diagnostic Tests. A complete blood count may
Examination. A careful history is important in show an elevated leukocyte count. The erythrocyte sed-
diagnosing the referred oral pain of myocardial infarc- imentation rate will be substantially elevated. Further
tion. Usually, the patient has a rather unusual story to workup and treatment are in the realm of the physician
tell, with fairly severe pain that began rather suddenly in and will likely include various thyroid function tests.
the left jaw and grew in intensity. The symptoms may Treatment. Subacute thyroiditis may resolve spon-
sound very much like a pulpitis. The pain might even taneously. Aspirin and occasionally steroids are used to
have moved from mandible to maxilla. The dentist must control the pain and inflammation. Thyroid supple-
rule out dental pathosis quickly and efficiently. ments are sometimes indicated.112
Diagnostic Tests. Radiographs and pulp testing of Carotid Artery. Stimulation of various parts of the
all of the teeth in the site of pain or rinsing with ice carotid artery in the region of the bifurcation has been
water will be equivocal. Analgesic block of the involved shown to cause pain in the ipsilateral jaw, maxilla,
tooth or teeth will fail to relieve the pain. teeth, gums, scalp, eyes, or nose.113 In the absence of
After localized dental or TMJ origins have been ruled other demonstrable pathema, unilateral dull, aching,
out, referred pain from the chest must be considered. sometimes throbbing pain in the jaws, temple, and
Treatment. If cardiac pain is suspected, the patient neck may be attributable to a carotid system arteritis,
must be referred to an emergency room immediately. It also known as carotidynia (carotid pain). This pain
is wise to call the hospital and have them ready to syndrome may be more prevalent than previously
receive the patient. If pain is severe, 5 to 10 mg of mor- reported in the literature because the constellation of
phine sulfate should be administered intramuscularly symptoms and findings may be confused with TMJ
or intravenously. Further exertion by the patient pain, MFP, salivary gland obstruction, and other
should be avoided to minimize oxygen demands placed extracranial sources of pain.
on the heart.
If the patient loses consciousness, the ABCs of car-
diopulmonary resuscitation should be applied until
help arrives.
Thyroid. The thyroid is a butterfly-shaped gland
situated in the neck superficial to the trachea at or
below the cricoid cartilage. Thyroid hormone regulates
the metabolic state of the body. Disorders of the thy-
roid gland are prevalent in medical practice, second
only to diabetes as an endocrine disorder.109 Subacute
thyroiditis (viral inflammation of the thyroid gland) is
of interest to the dentist because it may refer pain to the
jaws and ears.
Symptoms. The typical symptom picture includes
pain over at least one lobe of the thyroid gland or pain
radiating up the sides of the neck and into the lower
jaws, ears, or occiput. Swallowing may aggravate the Figure 8-21 Benign thyroid tumor that recurred following thy-
symptoms. This is usually associated with a feeling of roidectomy is referring pain into the mandibular first molar on the
pressure or fullness in the throat. There may be mild homolateral side.
Symptoms. The patient with carotidynia will most trigeminal tract. The normal cervical spine has 37 indi-
likely complain of constant or intermittent dull, vidual joints, making it the most complicated articular
aching, rarely pulsing jaw and neck pain, with inter- system in the body.119 Most of the structures in the
mittent sore throat or swollen glands. The pain may neck have been shown to produce pain when stimulat-
also involve the temple and TMJ region and radiate ed.120 Pain may be elicited through several different
forward into the masseter muscle with occasional con- pathologic processes including trauma; inflammation
comitant tenderness and fullness. Aggravating factors or misalignment of the vertebral bodies; inflammation
may include chewing, swallowing, bending over, or or herniation of the intervertebral disks; trauma or
straining. Females outnumber males approximately 4 strains to the spinal ligaments; and strains, spasms, or
to 1.114117 The syndrome may develop at any age but is tears of the cervical muscles.
most common over age 40. There may be a family his- Nonmusculoskeletal pain-producing structures of
tory of migraine. the neck include the cervical nerve roots and nerves
Etiology. The nerves innervating the adventitial and the vertebral arteries.120 Trauma, inflammation,
and intimal walls of the carotid artery are considered and compression are implicated in the etiology of pain
part of the visceral nervous system.118 The conver- from these structures as well.
gence-projection theory of referred visceral pain dis- Acute trauma and primary pathologic processes of
cussed earlier in this chapter may explain why pain is the neck are obviously not in the realm of the dentist to
referred from the carotid artery to the skin and muscles diagnose and treat; therefore, these will not be dis-
of the head and neck region. cussed. However, the cervical spine must be recognized
Some authors feel that the artery and its peripheral as a potential source of dermatomal and referred pain
branches are inflamed and that biopsy may reveal the into the head and orofacial region. Chronic subclinical
presence of inflammatory and giant cells.118 dysfunction of the cervical spine may produce com-
Precipitating factors may include an inflammatory plaints that first appear in the dental office. This dys-
response secondary to physical trauma or bacterial or function may serve as a powerful perpetuating factor in
viral infection, drugs, or alcohol.118 temporomandibular and facial pain disorders and
Others have found no evidence of inflammation and must be screened for and appropriately managed for
feel that the pain syndrome is owing to a pathophysio- successful treatment outcome.
logic mechanism similar to migraine.114 Elongation of Cervical Joint Dysfunction. Cervical joint dys-
the stylohyoid process is not thought to be a cause of function refers to a lack of normal anatomic relation-
this pain.116 ship and/or restricted functional movement of individ-
Examination. Examination may reveal tenderness ual cervical vertebral joint segments.
and swelling over the ipsilateral carotid artery along Etiology. In the craniocervical region, cervical
with pronounced throbbing of the carotid pulse.115 joint dysfunction may occur as the result of trauma (eg,
Palpation may aggravate the pain. Similarly, the exter- a whiplash injury), degenerative osteoarthritis, or
nal branches of the carotid system and surrounding chronic poor postural habits that result in sustained
areas may also be tender. This may include the mastica- muscular contraction and immobility. As the cervical
tory and cervical muscles, which may contain myofas- spine loses mobility and adapts to abnormal positions,
cial TrPs and lead to an erroneous diagnosis of muscu- nerve compression, nerve root irritation, neurovascular
loskeletal pain. Palpation over the sternocleidomastoid compression, posterior vertebral joint irritation, and
may aggravate the pain because of incidental irritation peripheral entrapment neuropathies may result.59,121
of the carotid vessel. The thyroid is nontender. All other Entrapment or chronic irritation of the nerve roots in
tests and examinations are normal. the C4 to C7 area generally produces pain in the
Treatment. Medications used in the treatment and respective dermatomes in the shoulder and arm
prevention of migraine headaches have been shown to regions (see Figure 8-19). Although C1, C2, and C3
be effective in controlling the symptoms of carotidy- nerve roots are not thought to be involved in compres-
nia.114 Some authors advocate the use of steroids and sion or peripheral entrapment-type problems,122 they
NSAIDs.117 Concomitant treatment of any myofascial do become inflamed through mechanical irritation by
TrPs will ameliorate the symptoms to some extent.116 other neighboring structures such as the vertebral
Cervical Spine. Disorders of the cervical spine and processes, muscles, or connective tissue capsules. When
neck area may refer pain into the facial region owing to this occurs, pain may be experienced in the craniofa-
convergence of cervical and trigeminal primary affer- cial, orofacial, mandibular, and temporomandibular
ent nociceptors in the nucleus caudalis of the spinal regions (the C2C3 dermatomes) (see Figure 8-19 and
Figure 8-22). Pain impulses from the first four upper spine should include range of motion in flexion, exten-
cervical roots are thought to be referred to the trigem- sion, lateral flexion, and rotation. Additionally, the
inal region (mainly V1 and V2) as a result of the prox- movement of the individual upper cervical segments
imity of the nucleus caudalis in the spinal trigeminal (occiputC1 and C1C2) should be evaluated.57,59
tract.32 The nucleus caudalis descends into the spinal Range of motion is often restricted with cervical dys-
cord as far as C3C4 (see Figure 8-8). These der- function. Upper cervical dysfunction may be unilateral
matomal and referred pain syndromes are particularly or bilateral.
important to the dentist. Radiographic evaluation may reveal osteoarthritis or
Symptoms. Local symptoms of cervical dysfunc- show a decreased cervical lordosis, evidence of soft tis-
tion may include stiffness, pain, and a limited range of sue spasm, or muscular shortening. Most commonly,
motion of the head and neck.120 The patient may also however, no pathologic radiographic findings are pres-
complain of throat tightness and difficulty swallow- ent. More sophisticated radiographic techniques can
ing.121 Dermatomal pains may have an aching or neu- pick up decreased cervical mobility.124
ritic quality and typically follow the distribution of the Treatment. Physical therapy, including cervical
cervical nerve root involved. Referred pains are usually joint mobilization along with a comprehensive home
deep and aching and may present as a unilateral exercise program and postural retraining, is required to
headache, as in a headache syndrome known as cer- treat pain of cervical origin.
vicogenic headache.32,123 This headache has a clinical Local treatment of referred symptoms does not pro-
picture similar to migraine except that the pain is vide long-lasting, if any, relief. If the patient has a true
strictly or predominantly unilateral and always on the dental or TM disorder and dysfunction of the cervical
same side. The patient may note that cervical move- spine, both problems must be addressed. Very often
ment or pressure on certain spots in the neck will pre- craniofacial pain will resolve once the cervical problem
cipitate a headache. is corrected. If pain exists in both regions, it is likely
Examination. Postural evaluation is essential for that the cervical problem is perpetuating the facial
all facial pain patients. Of particular importance is pain. It is extremely rare for pain to be referred in a
anterior head position. Examination of the cervical caudal direction.70 Thus, facial pain only rarely causes
neck pain.
Case History
The following is a classic example of misdiag-
nosis of a referred cervical pain problem. A 38-
year-old woman presented herself to the Pain
Management Center at the University of
California at Los Angeles (UCLA) with a 14-year
history of severe left hemicranial headaches that
had forced her to give up working. Because of the
unilateral distribution, they had previously been
misdiagnosed and unsuccessfully treated as
A migraine. However, the pain was strictly unilater-
al and was present on a continuous daily basis
(unlike migraine), with intermittent exacerba-
tions. The quality of the pain was described as dull
and aching, progressing to throbbing only when
severe. The patient also had an endodontic histo-
B ry involving the upper left second premolar,
reportedly still sensitive. The dental examination
Figure 8-22 A study by Poletti revealed a slightly different distri- revealed slight hyperocclusion of the involved pre-
bution of C2C3 dermatomes for pain than those previously molar, which was corrected. Thorough muscu-
defined by using tactile criteria. The upper figure (A) depicts the C2 loskeletal examination of the TMJ and cervical
and C3 tactile dermatomes previously defined by Foerster. The
lower figure (B) depicts C2 and C3 pain dermatomes as defined by
spine revealed a very prominent dysfunction of
Poletti. Reproduced with permission from Poletti CE. C-2 and C-3 atlas on axis on the left. There was no evidence of
pain dermatomes in man. Cephalalgia 1991;11:158. any internal derangement of the TMJ. Myofascial
examination revealed several active TrPs that Table 8-10 Intracranial Causes of Pain
reproduced her pain complaint.
Neoplasm Neurofibromatosis
Physical therapy, including cervical joint mobi-
Aneurysm Meningitis
lization along with a comprehensive home exer-
Hematoma/hemorrhage Thalamic pain
cise program and postural retraining, was insti-
Edema
tuted. As treatment progressed, the painful area
Abscess Cerebrovascular accidents
began to decrease in size until all that remained
Angioma Venous thrombosis
was the left TMJ and left lower-border mandible
pain the precise distribution of the C2 tactile
dermatome (see Figure 8-19, B and Figure 8-22,
A) and C3 pain dermatome (see Figure 8-22, B). nervous system lesions. Most of these problems will,
Myofascial TrP injections into the left splenius however, not be seen in the dental office and therefore
capitis muscle in conjunction with further physi- will not be discussed in detail.
cal therapy and a continued home program com- Intracranial lesions are rarely painful, but when they
pletely resolved the C1C2 dysfunction and the are, the pain is severe and difficult to treat.128 The qual-
associated dermatomal pain. The patient has now ity of pain may vary from a generalized throbbing or
been pain free for 18 years. aching to a more specific paroxysmal sharp pain.
Neurofibromatosis, a condition in which there are
The case of this patient illustrates how easy it would numerous pedunculated tumors of neurolemmal tissue
be to search in the TMJ and dental area for a cause for all over the body, is not painful unless the tumors press
the pain when the true culprit is actually the neck. The on nerves. Intracranial lesions are usually associated
role of cervical dysfunction and myofascial trigger with different focal neurologic signs or deficits such as
points in this type of pain presentation has been thor- weakness, dizziness, difficulty in speaking or swallow-
oughly discussed.125 ing, ptosis, areas of numbness, memory loss, or mental
confusion. If such neurologic signs or deficits appear
A TMJ disorder is unlikely to be causing all of with a pain complaint, pain from intracranial sources
our patients pain. However, on examination, a must be ruled out. This will require referral to a com-
restricted mandibular range of motion was found, petent neurologist or neurosurgeon. Treatment will
as well as radiographic evidence of degenerative depend on the diagnosis and may range from antibiot-
joint disease. Perhaps these are incidental find- ic or antiviral therapy for infective processes to surgical
ings. Alternatively, if the internal derangement is intervention for aneurysms and tumors to palliative
painful or the joint is inflamed, it may also be a pain management for inoperable cases.
contributing factor.
In our patient, presented earlier, extensive
Muscles. Myofascial TrP pain is discussed under examinations and sophisticated imaging tech-
Muscular Pains in this chapter. niques have already ruled out extracranial and
intracranial pathosis as causes for her pain,
INTRACRANIAL PATHOSIS although she does have active myofascial TrPs in
Although rare, intracranial lesions can cause pain refer- the trapezius muscle referring pain into the angle
ral to all areas of the head, face, and neck, including the of the jaw. This, however, does not account for her
oral cavity. Neurologic or neurosurgical evaluation is entire pain presentation. The other sources of pain
critical to rule out space-occupying lesions, intracranial must still be sought.
infections, or neurologic syndromes.
Intracranial causes of head and neck pain can be NEUROVASCULAR PAINS
classified into two groups: those caused by traction on This category of pain encompasses several of the pri-
pain-sensitive structures (which include the venous mary headache disorders (headaches not of pathologic
sinuses, dural and cerebral arteries, pia and dura mater, origin) such as migraines, cluster headache syndromes,
and cranial nerves) and those caused by specific central and simple intracranial vasodilation, as well as some
nervous system syndromes, such as neurofibromatosis, headaches associated with pathologic vascular disor-
meningitis, or thalamic pain126,127 (Table 8-10). ders, such as temporal arteritis (Table 8-11). The list
Different types of cerebrovascular accidents and includes only those headaches that have a higher likeli-
venous thrombosis may also cause painful central hood of presenting in the dental office.
Table 8-11 Neurovascular Pains In general, these headache types share the following
features. They all have primarily a deep, throbbing,
Migraines
pulsing, or pounding quality, occasionally sharp, and
Migraine with aura (classic)
occasionally with an aching or burning background.
Migraine without aura (common)
The pain is exclusively or predominantly unilateral
Migraine with prolonged aura (complicated)
with pain-free or almost pain-free periods between
Cluster headaches and chronic paroxysmal hemicrania
attacks. The main difference between the different
Cluster headache
headache types lies in their temporal patterns (Figure
Episodic
8-23) and their associated symptoms.
Chronic
Chronic paroxysmal hemicrania Migraine
Miscellaneous headaches unassociated with structural lesion
Symptoms. Migraine with aura, commonly
External compression headache
known as classic migraine, is distinguished by the
Cold stimulus headache
occurrence of transient focal neurologic symptoms
Benign cough headache
(the aura), 10 to 30 minutes prior to the onset of
Benign exertional headache
headache pain. Visual auras are most common and may
Headache associated with sexual activity
present as flashing lights, halos, or loss of part of the
Headaches associated with vascular disorders
visual field. Somatosensory auras are also common and
Arteritis
consist of dysesthesias that start in one hand and
Carotid or vertebral artery pain
spread up to involve the ipsilateral side of the face,
Hypertension
nose, and mouth.129 The headache itself is predomi-
Headaches associated with substances or their withdrawal
nantly unilateral in the frontal, temporal, or retrobul-
Acute substance use/exposure (nitrates, monosodium
bar areas, although it may occur in the face or in a sin-
glutamate, carbon monoxide, alcohol)
gle tooth. The pain may begin as an ache but usually
Chronic substance use/exposure (ergotamine, analgesics)
develops into pain of a throbbing, pulsating, or beating
Acute use withdrawal (alcohol)
nature. Associated symptoms may include nausea,
Chronic use withdrawal (ergotamine, caffine, narcotics)
vomiting, photo- and phonophobia, cold extremities,
Headaches associated with metabolic disorder
water retention, and sweating. The headaches are
Hypoxia
episodic and can last anywhere from several hours to 3
Hypoglycemia
days, with variable pain-free periods (days to years).
Dialysis
Migraine without aura or common migraine is
Adapted from Headache Classification Committee of the similar to migraine with aura except that the headache
International Headache Society.54 occurs without a preceding aura.
Migraine headaches are more common in females
and may begin in early childhood. The usual onset is
between the ages of 20 and 40 years, with 70% of these ity of these drugs to block neurogenic plasma extrava-
patients reporting a family history of migraine. Some sation and sterile inflammation.133 It is currently not
factors that may precipitate the headache include stress clear whether the ability of these drugs to cause vaso-
and fatigue, foods rich in tyramine (ripe cheese) or constriction has anything to do with pain relief.134
nitrates, red wines and alcohol, histamines, and Many headache researchers and clinicians feel that
vasodilators. Often patients with migraine, especially migraine without aura is the same as migraine with
migraine without aura, have overlying MFP, causing aura, except that the aura is absent or not dramatic
additional dull, aching headache pain. enough to be noted. Thus, the mechanism is thought to
be similar. There is, however, fairly good evidence that
Case History the pain of migraine without aura may actually be
The following is an example of an unusual owing to muscle tenderness and referred pain from
presentation of a migraine headache of particular myofascial TrPs rather than cerebral vascular
interest to the dentist. The patient was a 52-year- changes.135,136 In fact, the same blood flow studies that
old woman who had a 7-year history of pain in the showed intracranial vascular blood flow changes in
upper right quadrant, second premolar area, radi- migraine with aura failed to show any significant
ating to the right temple. The quality of pain was changes in migraine without aura.137
described as pulsing, sharp, and penetrating. The Examination. The diagnosis of migraine can usu-
temporal pattern was intermittent, with 2 to 3 ally be made by history. Nonetheless, examination of
days of pain followed by 1 to 2 weeks without the patient complaining of undiagnosed intermittent
pain. The symptoms occurred without any identi- toothache or facial pain should include a thorough
fiable precipitating factor, although loud noise dental, TMJ, and muscle evaluation. Once obvious den-
seemed to make the pain worse. Associated auto- tal and joint pathology has been ruled out, and the
nomic symptoms were absent. Previous unsuccess- qualitative and temporal pattern of the pain raises the
ful treatments included endodontic treatment of possibility of dental or facial migraine, referral to an
the right maxillary second premolar and an orofacial pain dentist should be made. Dental heroics
exploratory open flap in the same area, looking for should be avoided.
fractures or external resorption. Topical anesthet- Diagnostic Tests. There are no diagnostic tests
ics over the gingiva surrounding tooth #4 were that will confirm a diagnosis of migraine headache. If
similarly ineffective in relieving the symptoms. A the headache is of recent onset, a neurologic evaluation
diagnosis of migraine without aura was made including a CT scan or an MRI may be indicated.
based on the quality and temporal pattern of the Thermography during an acute attack of migraine does
pain and the absence of dental pathema to show areas of increased blood flow on the side of the
explain the symptoms. Treatment with abortive headache.138,139
migraine medications proved quite successful. Treatment. Long-term management of migraine
headache typically requires identification and control
Etiology. The exact etiology and pathogenesis of of any obvious precipitating factors. Restriction of
migraine with aura headaches remain controversial. alcohol intake and elimination of tyramine-containing
The prevailing view is that migraine pain originates foods140 are simple yet sometimes effective means of
from the vascular and nervous tissues in and around decreasing the frequency of migraine attacks. Regular
the brain. The pain is thought to be referred to the meals and good sleep hygiene also help prevent the
more superficial cranial structures through conver- onset of migraine. If myofascial TrPs or musculoskele-
gence of vascular and somatic nerve fibers on single tal dysfunction are present, competent treatment of
second-order pain transmission neurons in the trigem- these will significantly reduce the frequency of the vas-
inal nucleus caudalis.130 A sterile neurogenic inflam- cular headache symptoms and reduce the need for
mation caused by the release of vasoactive neuropep- migraine medications. For those patients in whom
tides from nerves surrounding the affected intracranial stress, depression, or anxiety play a role, psychological
vasculature is thought to be the nociceptive source. It is interventions such as stress management and relax-
postulated that documented cerebral blood flow ation training, biofeedback, or cognitive behavioral
changes seen in various studies131,132 may be a trigger therapy may be indicated.
for the events leading to the inflammation. The effica- Medications used in the treatment of migraine
cy of the ergot alkaloids and a newer family of drugs include abortive and prophylactic drugs, the choice of
called triptans appears to be attributable to the abil- which depends on the frequency of migraine attacks.
Individuals who suffer less than three or four migraines characteristic. Precipitating factors may include alcohol
per month may do well with abortive drugs that are or other vasodilating substances, such as nitroglycer-
taken during the onset of the headache or migrainous ine. Cluster headache patients typically pace the floor
facial pain. Abortive drugs are particularly useful in during their headaches owing to the intensity of pain.
migraine with aura for which the aura warns the This is in contrast to the migraine patient, who retreats
patient that a headache is pending. The newest abortive to a dark room to sleep.
drugs are the triptans, of which Imitrex (sumatrip- Cluster headaches may progress from the more clas-
tan) was the first. Various ergotamine preparations, sic episodic form, occurring in periods lasting 1 week
long the drugs of first choice for migraines, are also to 1 year, with at least 2-week pain-free periods
available. The latter are effectual and somewhat less between, to a chronic form in which remissions are
expensive, but nausea and vomiting are frequent, unde- absent or last less than 2 weeks.54 Rarely is the chronic
sirable side effects. Prophylactic medications are used form present from the onset.
when headache frequency exceeds three or four per
month since the triptans may cause coronary Case History
vasospasm or ischemia and ergot preparations, potent The following history was obtained from a 42-
peripheral vasoconstrictors, may cause peripheral vas- year-old man who had suffered from cluster
cular problems. Prophylactic medications include - headaches for 27 years. The pain, located retro-
blockers, tricyclic antidepressants, calcium channel orbitally on the right side, was described as inter-
blockers, and others. mittent, sharp, excruciating, and knife-like.
Associated symptoms included tearing of the right
Cluster Headache and Chronic Paroxysmal eye, stuffiness of the right nostril, numbness on the
Hemicrania right side of the face, and right conjunctival injec-
These headaches are classified together because they tion. The pain occurred one or two times per year
share several clinical characteristics and may have sim- in cluster periods of 1 to 5 weeks duration. The
ilar etiologic mechanisms. Nonetheless, they are easily headaches typically lasted 60 to 75 minutes and
distinguishable clinically and clearly differ from could occur multiple times per day. During an
migraine. attack, the patient would pace the floor and hit his
Symptoms. Cluster headaches derive their name head against doors and walls. He noted that red
from their temporal pattern. They tend to occur in wine could precipitate an attack and avoided
clusters, a series of one to eight 20- to 180-minute alcohol during headache periods. Past trials of
attacks per day lasting for several weeks or months, fol- various migraine medications were all without
lowed by remissions of months or years54,141,142 (see benefit. Oxygen inhalation at the onset of a
Figure 8-23). These headaches are found five to eight headache attack, however, immediately relieved
times more frequently in men than in women, particu- the pain. Of importance was a past medical histo-
larly in men aged 20 to 50 years who smoke. The pain ry of myocardial infarction at age 35 and poorly
is a severe, unilateral, continuous, intense ache or burn- controlled hypertension. These factors impacted
ing that often occurs at night. Movements that increase treatment and will be discussed.
blood flow to the head may result in throbbing. The
most common sites are either around and behind the Chronic paroxysmal hemicrania (CPH), as the name
eye radiating to the forehead and temple or around and implies, is typically an unremitting, unilateral headache
behind the eye radiating infraorbitally into the maxilla disorder, although episodic versions have been identi-
and occasionally into the teeth, rarely to the lower jaw fied.144 Chronic paroxysmal hemicrania is characterized
and neck. Because of the oral symptoms, serious diag- by short-lasting (2 to 45 minutes), frequently occurring
nostic errors are committed by dentists. Researchers attacks of pain (five per day for more than half of the
from UCLA reported that 42% of 33 patients suffering time).54,145 The quality of pain is throbbing or pound-
cluster headache had been seen by dentists and that ing, with an intensity that parallels that of cluster
50% of these patients received inappropriate dental headaches, the patient often choosing to pace the floor
treatment.143 during an attack. Pain location is predominantly ocu-
Prodromal auras are absent with cluster headaches, lotemporal and frontal, always on the same side, and
but nasal stuffiness, lacrimation, rhinorrhea, conjuncti- can spread to involve the entire side of the head and the
val injection, perspiration of the forehead and face, and neck, shoulder, and arm.145 Cases involving CPH pre-
Horners syndrome (ptosis of upper lid and miosis) are senting as intermittent toothache have been report-
ed.146 Turning or bending the head forward may pre- ies of the cardiovascular and sweat responses as well as
cipitate an attack in some cases.147 Associated symp- cognitive processing in the two headaches suggest that
toms include unilateral lacrimation, nasal stuffiness, they are different.153,154
and conjunctival injection. Nausea and vomiting are Examination. Cluster Headaches. Diagnosis is
usually absent, as are visual or somatosensory auras. In based on signs and symptoms. There are no diagnostic
contrast to cluster headache, CPH is seen predominant- tests to confirm a diagnosis of cluster headache. Either
ly in women.148 Age at onset appears to be 20 years, the patient presents with a typical history and no
although a variable pre-CPH period may exist.148 abnormalities on physical and neurologic examination
or the examination may cause suspicion of organic
Case History lesions with an ultimately normal neuroimaging
A 21-year-old woman presented with a 3-year scan.54 Mild ptosis and miosis with or without perior-
history of right-sided supraorbital headaches. bital swelling and conjunctival congestion may be pres-
These headaches had a full, tight, aching quality ent on the side of the headache if the patient is seen
with shooting, stabbing exacerbations brought on during or shortly after an attack.142
by rapid head movement, sneezing, or running. Chronic Paroxysmal Hemicrania. As with cluster
Associated symptoms included ptosis and tearing of headache, a careful history is the primary basis for
the right eye. The pain lasted approximately 1 hour diagnosis. Organic lesions should always be ruled out
and occurred three to four times per day. The with any new headache disorder.
longest the patient had ever been without pain Treatment. Definitive treatment of cluster
since the onset of the headaches was less than 5 headaches and CPH is best left to the orofacial pain
days. The headache was completely responsive to dentist or other health care provider with a specific
indomethacin (NSAID), which is typical of CPH. interest in headache management.
Of interest was a family history of cluster headaches Cluster Headaches. Many of the treatments used
in her father and a cousin of her mother. for migraine therapy are also useful in cluster
headaches, including symptomatic use of subcuta-
Etiology. Cluster Headaches. The exact etiology neous sumatriptan.155,156 In general, however, prophy-
or mechanism of cluster headaches, and CPH for that lactic medications are more appropriate in cluster
matter, is as yet unknown. Over the years, many theo- headache because of the frequency of attacks and
ries have been advanced to try to explain the pro- because prodromal warning symptoms are rare.
nounced sympathetic and parasympathetic symptoma- Cluster headache patients are often wakened from
tology, the trigeminal distribution of the pain, and the sleep, and the pain reaches its high intensity very quick-
periodicity. To date, no consensus has been reached. ly. Once the cluster period subsides, patients are
Vasodilation, once considered an important element in weaned from medications until the headaches recur.
the pathogenesis of cluster, is now thought to be sec- Oxygen inhalation (100% 7 to 8 L per minute with a
ondary to trigeminal activation.142 This is because the nonrebreathing mask), given at the very beginning of
pain of cluster headache typically precedes any an attack for 15 minutes, may be successful in aborting
extracranial blood flow changes, and intracranial blood an attack. Oxygen and subcutaneous sumatriptan are
flow studies have shown inconsistent results.142 The also useful as abortive options for the patient taking
unusual temporal pattern of cluster headaches impli- prophylactic medications who is experiencing break-
cates the hypothalamus, which regulates autonomic through headaches. In rare cases of resistant chronic
functions and also largely controls circadian rhythms, cluster headache, trigeminal ganglion lysis or gamma
as possibly triggering the primary neuronal discharge knife treatment may be considered.157160
resulting in cluster headache pain.142,149 Studies of cir- Chronic Paroxysmal Hemicrania. Indomethacin is
cadian changes in various hormone levels in cluster the medication of choice for CPH. If the pain does not
patients versus controls do support activation of the resolve with this medication, it is unlikely to be CPH.
hypothalamic gray matter region during cluster Aspirin and naproxen have a partial effect, but the relief
headache.142,150,151 Others propose a complex neu- is not as dramatic as with indomethacin.145
roimmunologic mechanism.152
Chronic Paroxysmal Hemicrania. The pathophysi- Miscellaneous Headaches Unassociated with
ology of CPH is also unknown. Because of the auto- Structural Lesion
nomic and temporal similarities of CPH with cluster Symptoms. These headaches, which include exter-
headache, similar mechanisms are implicated, yet stud- nal compression headache, cold stimulus headache,
benign cough headache, benign exertional headache, which does, on occasion, present with dental symp-
and headache associated with sexual activity,54 are usu- toms, may produce serious, irreversible consequences if
ally bilateral, short-lasting, and clearly related to a well- left unrecognized and untreated.
defined precipitating factor. For example, cold stimulus
headache may result from exposure of the head to cold Giant Cell Arteritis (Temporal Arteritis)
or from ingestion of cold substances. Headache or facial pain from giant cell arteritis is rela-
The latter headache, also known as ice cream tively rare, but the dentist must know about this disor-
headache, typically occurs in the middle of the fore- der and be able to recognize it because blindness is a
head after cold food or drink passes over the palate serious potential complication.
and lasts less than 5 minutes. Benign cough headache Symptoms. The patient with giant cell arteritis is
is a bilateral headache of extremely short duration (1 usually over 50 years old and may have other rheumat-
minute) that is precipitated by coughing. Physical ic symptoms, such as polymyalgia rheumatica.
exertion may also result in bilateral throbbing Involvement of the temporal artery may bring the
headaches that may last anywhere from 5 minutes to patient in to see the dentist first because pain with mas-
24 hours. In some individuals, sexual excitement pre- tication (jaw claudication) may be the first or only
cipitates bilateral headache. This headache intensifies symptom. Friedlander and Runyon reported patients
with increasing sexual arousal and may become with a burning tongue and claudication of the muscles
explosive at orgasm. of mastication.162 Guttenberg et al. reported a case
Etiology. External compression headache is pre- mimicking dental pain that led to inappropriate, inef-
cipitated by prolonged stimulation of the cutaneous fective endodontic surgery.163
nerves through pressure from a tight band, hat, swim The pain is usually unilateral and in the anatomic
goggles, or sunglasses. Cold stimulus headaches are area of the artery but may also radiate down to the ear,
caused by exposure of the head to cold or from sudden teeth, and occiput with generalized scalp tenderness.
stimulation of the nasopalatine or posterior palatine Temporal arteritis may resemble a migraine attack
nerves with cold foods such as ice cream.54 Benign because it, too, has a persistent throbbing quality that
cough and exertional headaches, as well as headaches may last hours to days and the location is unilateral,
associated with sexual activity, seem to occur more over the temple area.114 Temporal arteritis, however,
commonly in people with a history of migraine. The has an additional burning, ache-like quality. The pain
exact mechanism underlying these headaches is increases with lowering of the head, mastication, and
unknown but may be related to increased venous pres- movements that create increased blood flow to that
sure in the head, transient hypertension, muscle con- artery. The patient may present with complaints of
traction, increased sympathetic tone, or possibly the malaise, fatigue, anorexia, and weight loss if the arteri-
release of vasoactive substances.161 tis occurs as a febrile illness. In advanced cases, patients
Treatment. Most of these headaches can be pre- may complain of transient visual loss on the side of the
vented by avoiding the precipitating cause (eg, pressure headache. This is particularly severe and requires
from swim goggles, exposure of the head to cold, rapid immediate, aggressive treatment since thrombosis of
ingestion of cold substances, exertion). If necessary, the ophthalmic artery may result in partial or complete
frequent exertional headaches can be treated with pro- blindness.
phylactic medications such as propranolol or Etiology. Arterial inflammation, which may often
NSAIDs.161 be associated with immunologic disorders, is the
causative factor in this headache. Arterial biopsy often
Headaches Associated with Vascular Disorders reveals frayed elastic tissues and giant cells in the vessel
This category includes headaches that are attributable walls on histologic examination.164
to demonstrable pathosis, such as giant cell arteritis or Examination. Dental examination is negative. The
acute hypertension. Other pathologic vascular causes temporal artery may be tender to palpation, thickened,
of headache include vertebral or carotid artery dissec- and enlarged and may lack a normal pulse. Digital
tion and intracranial ischemia owing to intracranial pressure with occlusion of the common carotid artery
hematoma, subarachnoid hemorrhage, arteriovenous on the same side will frequently alleviate the symp-
malformations, or venous thrombosis (see Table 8-11). toms. Ophthalmologic examination or evaluation of
Headaches owing to such intracranial pathosis are optic ischemia is mandatory.
unlikely to appear in the dental office and are therefore Diagnostic Tests. Erythrocyte sedimentation rate,
not further described. Giant cell arteritis, however, although a nonspecific test, will be significantly elevat-
ed above 60 mm/hour Westergren in giant cell arteritis. Our patients pain had none of the characteris-
Definitive diagnosis is based on arterial biopsy. The tics described in this category of pain. Therefore,
entire temporal artery is typically removed to ensure vascular headaches can be excluded in the differ-
sampling of diseased sections; skip lesions are com- ential diagnosis.
mon. Biopsy of the artery is essential because treatment
involves high doses of steroids, but treatment is never NEUROPATHIC PAINS
delayed if visual disturbance is present. Neuropathic pains are caused by some form of struc-
Treatment. The dentist who suspects temporal tural abnormality or pathosis affecting the peripheral
arteritis should immediately refer the patient to a nerves themselves. This is in contrast to the normal
rheumatologist or internist for complete workup. If transmission of noxious stimulation along these
optic symptoms are present, emergency ophthalmolog- nerves from organic disease or trauma. The structural
ic examination is essential without delay. abnormality or pathosis affecting the nerve(s) may
Treatment of the condition consists of emergency have many different etiologies, including genetic dis-
dosages of steroids. When the elevated sedimentation orders such as porphyria; mechanical damage from
rate has been reduced, maintenance doses of pred- compression, trauma, entrapment, traction, or scar-
nisone are administered as clinically determined. ring; metabolic disorders such as diabetes, alcoholism,
Carotid or Vertebral Artery Pain. Dissection of nutritional deficiencies, or multiple myeloma; toxic
the carotid or vertebral arteries causes headache and reactions to drugs, metals, or certain organic sub-
cervical pain on the same side as the dissection. This stances; or infectious or inflammatory processes such
serious, life-threatening condition is typically acute as herpes, hepatitis, leprosy, or multiple sclerosis.
and accompanied by symptoms of transient ischemic Not all neuropathies are painful. When they are, they
attack or stroke. Since patients with this problem are may be dramatically so. The distinguishing feature of
unlikely to appear in the dental office, there need be no peripheral neuropathic pains in the head and neck
further discussion of this type of syndrome. region is the quality of pain, which is burning, sharp,
Idiopathic carotidynia was discussed under the cat- shooting, lancinating, or electric-like. The distribution
egory of referred pain from remote pathosis. of the pain is limited to the anatomic pathways of the
nerve involved and is almost always unilateral. Sensory
Hypertension
abnormalities may include diminished pain sensation
Symptoms. Generalized throbbing headache may in the presence of hypersensitivity to typically non-
be a symptom of acute hypertension, especially if the painful stimuli.
diastolic pressure rises 25%.54 In general, neuropathic pains in the head and neck can
Etiology. Usually, abrupt increases in blood pres- be divided into two main groups, paroxysmal or contin-
sure are associated with ingestion of a substance that uous, based on their temporal pattern (Table 8-12).
causes vasoconstriction or a systemic disorder such as
pheochromocytoma, preeclampsia or eclampsia in Paroxysmal Neuralgias
pregnancy, or malignant hypertension. Chronic arteri- Symptoms. Paroxysmal, lancinating, sharp, unilat-
al hypertension is not reported to cause headache.165 eral pain that follows a distinct dermatomal pattern is
Examination. A routine blood pressure check is common to all paroxysmal neuralgias. The pain is often
useful to rule out hypertension as a medical problem
requiring treatment.
Treatment. Patients with acute or chronic hyper- Table 8-12 Neuropathic Pains
tension should be referred to their family practition- Paroxysmal
er for management. Associated headaches resolve Trigeminal neuralgia
within 24 hours to 7 days after resolution of the Glossopharyngeal neuralgia
hypertension. Nervus intermedius neuralgia
Headache Associated with Substances or Occipital neuralgia
Their Withdrawal and Headache Associated with Neuroma
Metabolic Disorders Continuous
Postherpetic neuralgia
These headache types are unlikely to present as a pri-
Post-traumatic neuralgia
mary complaint in the dental office and thus will not be
Anesthesia dolorosa
discussed further here.
described as electric-like, shooting, cutting, or stab- Movement, usually opening of the mouth, may trigger
bing. The attacks may last only a few seconds to min- the pain.
utes, with virtually no discomfort between attacks. Dental pathosis may be minimal or absent. Retained
Sometimes patients notice vague prodromata of tin- root tips are the most common finding, and their
gling and occasionally ache or burn after an attack. The removal has been associated with remission of pain.
attacks may occur intermittently, with days to months Obvious dental pathosis should be treated, but dental
between a series of attacks. Usually, patients complain heroics in the absence of clinical or radiographic find-
of trigger areas that, when stimulated, precipitate an ings should be avoided. A UCLA group reported that
attack. These are frequently located within the distri- 61% of the cases with PTN or trigeminal neuralgia
bution of the nerve affected, usually on the skin or oral were incorrectly diagnosed and treated for dental con-
mucosa. Neural blockade of the trigger area almost ditions.168 Onset of classic trigeminal neuralgia may be
always relieves the pain for the duration of action of the quite sudden and occurs in the same division affected
local anesthetic. Should neural blockade fail to relieve by the PTN symptoms. Onset may follow remission
the symptoms, either the diagnosis or the nerve block produced by previous dental treatment.
technique must be questioned.
Each type of paroxysmal neuralgia has its own dis- Case History
tinct characteristics. A 67-year-old man underwent extensive dental
Trigeminal neuralgia, or tic douloureux, usually treatment, including endodontic therapy and
affects one or at most two divisions of the fifth cranial hemisection of tooth #30, followed by the place-
nerve.54 The mandibular and maxillary divisions are ment of two different intraoral stabilization appli-
most commonly involved together, causing pain to ances, for a pain complaint that turned out to be
shoot down the mandible and across the cheek into the trigeminal neuralgia. He had also seen a general
teeth or tongue. The maxillary or mandibular divisions medical practitioner and a neurologist, who were
alone are the next most frequently affected, with oph- unable to identify a cause for his pain. A diagnosis
thalmic division neuralgias being the least common. The of psychogenic pain was made. The reason the true
pain is unilateral 96% of the time. Touching and wash- diagnosis was not obvious was because the patient
ing the face, tooth brushing, shaving, chewing, talking, described the pain as constant and related to tooth
or even cold wind against the face may set off the trigger #30, worsened by eating and talking. Careful ques-
and result in pain. Deep pressure or painful stimuli are tioning, however, revealed that the pain was not
usually tolerated without a painful episode. Patients go constant. Indeed, if he sat very still without talking
to extraordinary lengths, such as not shaving, washing, or moving his mouth, he was pain free. Movement
or brushing their teeth, to avoid stimulating the trigger of the tongue, touching the lower lip, and biting
area. Between attacks, patients are completely pain free. anywhere in the mouth seemed to be precipitating
Long remissions for months or years are not uncommon factors. Observation of an attack during the histo-
but tend to decrease with increasing age. ry and physical examination confirmed the diag-
Trigeminal neuralgia is almost twice as common in nosis: the patient became very quiet, his lips began
women as in men and usually starts after the age of to tremble, and tears came to his eyes because the
50.166 Anyone under the age of 40 with this disorder pain was so intense. The whole episode lasted less
should be referred to a neurologist to be worked up for than a minute, after which the patient resumed
a structural lesion or multiple sclerosis. normal conversation.
A syndrome of pain preceding the onset of true
paroxysmal trigeminal neuralgia, known as pretrigem- Glossopharyngeal neuralgia is 70 to 100 times less
inal neuralgia (PTN), has been described.167,168 common than trigeminal neuralgia.169 The symptoms
Patients may present themselves up to 2 years before include unilateral and rarely nonconcurrent bilateral
developing trigeminal neuralgia, with pain usually stabbing pain in the lateral posterior pharyngeal and
localized to one alveolar quadrant and sometimes a tonsillar areas, the base of the tongue, down into the
sinus. They may describe this pain as dull, aching throat, the eustachian tube or ear, and down the
and/or burning, or as a sharp (burning) toothache, not neck.170 Sometimes pain radiates into the vagal region
unlike pain arising from the dental pulp. Some and may be associated with salivation, flushing, sweat-
patients may also report a pins and needles sensation. ing, tinnitus, cardiac arrhythmias, hypertension, verti-
Duration of PTN pain may be 2 hours to several go, or syncope. Throat movements, pressure on the
months, with variable periods of remission. tragus of the ear, yawning, or swallowing may trigger
the pain. Again, local anesthesia of the trigger area tem- Etiology. The paroxysmal neuralgias are consid-
porarily prevents precipitation of attacks. This can be ered symptomatic if a specific pathologic process
accomplished by spraying the posterior pharynx with a affecting the involved nerve can be identified and idio-
topical anesthetic. pathic if not. Paroxysmal neuralgias rarely occur in
Eagles syndrome may be the cause of symptoms young people unless there is a distinct compression of
similar to those of glossopharyngeal neuralgia,171173 the nerve by a tumor or other structural lesion.
although some believe that this syndrome is not suffi- Compression of the nerve either peripherally or cen-
ciently validated.54 The symptoms, which include a trally by bone, scar tissue, tumors, aberrant arteries, or
sore throat and posterior tongue and pharyngeal arteriovenous malformations causes focal demyelina-
pain, are thought to be related to compression of the tion, which is postulated to result in ectopic firing and
area of the glossopharyngeal nerve by a calcified elon- reduced segmental inhibition of the low-threshold
gation of the stylohyoid process of the temporal mechanoreceptors and wide-dynamic-range relay neu-
bone. Precipitating factors include fast rotation of the rons.177 The net effect is a lowered threshold of neu-
head, swallowing, and pharyngeal motion from talk- ronal firing for which ordinary orofacial maneuvers
ing and chewing. Blurring of vision and vertigo are such as chewing, swallowing, talking, or smiling may
rarely seen. precipitate a neuralgic attack.
Nervus intermedius neuralgia is extremely rare.174 Trigeminal neuralgia, along with other paroxysmal
The pain is described as a lancinating hot poker in cranial neuralgias, is typically considered idiopathic,
the ear.170 It can occur anterior to, posterior to, or on although nerve compression by intracranial arteries
the pinna; in the auditory canal; or, occasionally, in the that have become slack and tortuous with age is
soft palate. A duller background pain may persist thought to be the likely culprit.178 The demyelinating
between attacks. Attacks may be accompanied by sali- lesions associated with multiple sclerosis may also pre-
vation, tinnitus, vertigo, or dysgeusia.175 The trigger cipitate trigeminal neuralgia in younger individuals.
area is usually in the external auditory canal. This neu- The symptoms of trigeminal neuralgia associated with
ralgia has also been termed Ramsay Hunt syndrome, diabetic polyradiculopathy have also been reported.179
geniculate neuralgia, or Wrisbergs neuralgia and is Despite the apparent idiopathy of trigeminal neural-
often associated with herpes zoster (or shingles). gia, there are numerous published observations that
Superior laryngeal neuralgia is also a rare neural- suggest that some cases may have an intraoral etiology.
gia with paroxysmal neuralgic pains of varying dura- From Ratner et al.s jaw bone cavities, also known as
tion, minutes to hours, located in the throat, in the residual infection in bone or chronic, smoldering,
submandibular region, or under the ear. Triggering nonsuppurative osteomyelitis, to Bouquot et al.s neu-
factors include swallowing, turning the head, loud ralgia-inducing cavitational osteonecrosis (NICO
vocalizations, or stimulating the site overlying the lesions), there are several anecdotal reports in the liter-
hypothyroid membrane where the nerve enters the ature of successful relief of trigeminal neuralgialike
laryngeal structures. pain with surgical exposure and curettage of jaw bone
Occipital neuralgia occurs in the distribution of the cavities.180187 Microbiologic sampling of these cavities
greater or lesser occipital nerves to the back of the head using aseptic precautions revealed, in many cases, the
and mastoid process. The ear and the underside of the presence of a wide variety of both nonpathologic and
mandible may be involved because of the dermatomal pathologic oral microorganisms.180 Microscopic exam-
patterns of C2 and C3 (see Figures 8-19, B, and 8-22). ination of tissue removed from these bone cavities has
The pain often radiates into the frontal and temporal revealed neuromas in 50% of cases and frequent
regions, occasionally with the same sharp, electric-like myelin degeneration.188,189 Bouquot et al. examined
character of the other neuralgias, but may last hours 224 tissue samples removed from alveolar bone cavities
instead of seconds. Sometimes the pain takes on a more in 135 patients with trigeminal neuralgia or atypical
continuous burning, aching nature. A case of maxillary facial neuralgia. They reported evidence of chronic
right posterior quadrant dental pain owing to occipital intraosseous inflammation in all of the samples.184
neuralgia has been reported.176 Trauma, especially Retrospective identification and follow-up by ques-
rotational injuries to the neck, may precede the onset. tionnaire of 190 patients who had had jaw bone curet-
Trigger zones, such as those seen with trigeminal neu- tage of histologically confirmed inflammatory jaw
ralgia, are rare. The pain may be associated with neck bone lesions for neuralgic pain showed 74% with sig-
and back pain, and emotional stress is a common nificant improvement over 4 years. Approximately one-
aggravating factor. third of these had required additional curettage.190
Although these findings are provocative, they are infections or neoplasms.61,196,197 Since nerve compres-
surrounded by controversy. Loeser, a neurologist, noted sion from intracranial tumors, aneurysms or vascular
that many normal subjects also have bone cavities and malformations, or central lesions from multiple sclero-
that not all patients with trigeminal neuralgia or unex- sis may also cause symptomatic trigeminal neural-
plained facial pains have these cavities.191 A surprising gia,198,199 all patients with trigeminal neuralgialike
number of dentists, and particularly oral surgeons, symptoms should be worked up with an imaging study
concur with Loeser. of the head, either contrast-enhanced CT or MRI, in
In marked contrast, Raskin, also a neurologist, has addition to routine films.
addressed this problem and has stated, Diagnosis of pretrigeminal neuralgia is based on the
clinical presentation of constant dull toothache pain in
[I am speaking] of the people who have nonde- the absence of dental or neurologic findings and nor-
script pain when I cant make any further diagno- mal radiographic, CT, or MRI examinations.
sis. If they have a tooth extraction site on the side Since glossopharyngeal neuralgia is more often asso-
of their pain, I have the oral surgeon do a local ciated with nasopharyngeal, tonsillar, or posterior fossa
anesthetic block. If that stops their pain, they then tumors or other pathosis than is trigeminal neuralgia,
get that mandibular or maxillary bone explored imaging studies including skull films, panoramic films,
and curetted. If I can cure trigeminal neuralgia and MRI are essential.
with a 45 minute dental procedure rather than In Eagles syndrome, the diagnosis is usually estab-
[the patient] taking Tegretol, Im all for it. I would lished on the basis of radiographs, as well as intraoral
rather have some negative explorations, if thats finger palpation of the posterior pharyngeal area.
what it takes, to save someone either a posterior Panoramic films should reveal a stylohyoid process
fossa operation or taking some drug for the next that is so long that its image projects beyond the ramus
20 years. I go hard on this. It is still contentious I of the mandible. Anything shorter is not significant,
know. I am quite impressed, and I dont think we and other causes for the patients pain should be
can afford to ignore this data.192 sought. Pain is alleviated temporarily by neural block
of the suspected compressive area. Treatment is prima-
Glossopharyngeal neuralgia is much more fre- rily surgical shortening of the styloid process either
quently a frankly symptomatic neuralgia. Tumors are through an intraoral or an extraoral approach.171
found in 25% of cases. Local infection, neck trauma, Occipital neuralgia requires a thorough muscu-
elongation of the styloid process (Eagles syndrome), loskeletal evaluation in addition to a cervical spine
and compression of the nerve root by a tortuous verte- radiographic series to rule out neoplasms or other local
bral or posterior inferior cerebellar artery193 are other destructive lesions. Digital palpation of the greater
symptomatic causes of this ninth-nerve neuralgia. occipital nerve along the nuchal line may be painful.
Unlike trigeminal neuralgia, glossopharyngeal neural- Caudal pressure to the vertex of the head while it is
gia is almost never associated with multiple sclerosis.169 flexed and rotated toward the side of the pain may
Occipital neuralgia may be secondary to hyper- reproduce cervical compression symptoms.200 Sensory
trophic fibrosis of subcutaneous tissue around the loss is rare. Because myofascial TrPs may mimic or
occipital nerve following trauma, irritation of the nerve accompany this disorder, careful palpation of the pos-
by the atlantoaxial ligament, spondylosis of the upper terior cervical muscles for the tight bands and focal
cervical spine, spinal cord tumors, or tubercular gran- tenderness with referred pain, characteristic of myofas-
ulomas.194 Myofascial TrPs in the semispinalis capitis cial TrPs, is essential.196
and splenius cervicus muscles may mimic this type of Treatment. Obviously, if a neuralgia is sympto-
pain or may cause neuralgia-like symptoms owing to matic or the result of identifiable pathema or struc-
entrapment of the greater occipital nerve as it passes tural lesion, treatment is directed at correction of the
through the tense semispinalis muscle fibers.55 Since cause. For example, stylohyoid resection may be indi-
treatment of myofascial TrPs is noninvasive, with very cated if this is the cause of glossopharyngeal neuralgia.
low morbidity and no mortality, they must be carefully However, for idiopathic paroxysmal neuralgias, the first
ruled out before neurectomy or other neuroablative treatment of choice is the drug carbamazepine
techniques are considered.195 (Tegretol). Carbamazepine is most efficacious in
Examination. A patient presenting with symp- trigeminal neuralgia but has some success in glos-
toms of trigeminal neuralgia must be worked up for sopharyngeal or nervus intermedius neuralgias as well.
dental disorders, sinus disease, and head and neck Baclofen (Lioresal), gabapentin (Neurontin), and
diphenylhydantoin (Dilantin) are also used, alone or cave. They are usually carried out by a neurosurgeon
in combination. All of these medications may cause under local anesthesia with fluoroscopic control and
varying degrees of dizziness, drowsiness, and mental take less than 45 minutes. The patient is conscious for
confusion. In addition, carbamazepine may cause both of these percutaneous procedures. Because they
hematopoietic changes and baclofen may affect liver are relatively simple procedures, with low morbidity
enzymes. Although such side effects are not as common and mortality, they can easily be repeated should the
as once thought and are less common with gabapentin symptoms return. Rare complications include corneal
and diphenylhydantoin, patients taking any of these anesthesia, anesthesia dolorosa, injury to the carotid
medications must be monitored very closely initially. artery, and sixth cranial nerve palsy.208,209
In those infrequent instances for which these med- Therapies, especially medications, used to treat true
ications or combinations thereof are ineffective, or the trigeminal neuralgia have been reported to work for
patient becomes refractory to the medications or can- pretrigeminal neuralgia as well.210
not tolerate them, either owing to severe drowsiness or Idiopathic glossopharyngeal neuralgia may be man-
frank allergy, neurosurgical intervention remains an aged with the same medications used for trigeminal
option. In trigeminal neuralgia, gamma knife radio- neuralgia. If these fail, microvascular decompression
surgery is the newest alternative for treatment. Gamma has been reported effective.211 Nerve section in the pos-
knife radiosurgery is a neurosurgical technique using a terior fossa212 and percutaneous thermocoagulation
single-fraction high-dose ionizing radiation focused on have also been described, with mixed results.213,214
a small (4 mm), stereotactically defined intracranial Because of its predominantly musculoskeletal etiol-
target.201 The targeted cells necrotize without apparent ogy, occipital neuralgia lends itself best to nonpharma-
harm to adjacent tissues. In trigeminal neuralgia, the cologic and nonsurgical treatments. Consequently,
beam is focused on the trigeminal sensory root adja- physical therapy, postural re-education, corrected
cent to the pons. The results have been so good202,203 ergonomics, home neck-stretching exercises, TrP injec-
that some authors advocate gamma knife radiosurgery tions, and even C2 nerve blocks, with or without corti-
as the safest and most effective form of treatment cur- costeroids, are the first line of approach.195 Surgical
rently available for trigeminal neuralgia.202 The pro- interventions, such as neurectomy,215 rarely provide
cedure carries with it low morbidity (infrequent long-term relief.216
reports of delayed onset of facial tactile hypesthesia or Surgical section of the nervus intermedius or the
paresthesias) and no mortality.201 Nonetheless, the chorda tympani has been reported to relieve the pain of
long-term effects of this form of treatment have yet to nervus intermedius neuralgia, as has neurectomy in the
be evaluated, and more traditional approaches to the case of recalcitrant superior laryngeal neuralgia.217,218
surgical treatment of trigeminal neuralgia are still used, Neuromas are non-neoplastic, nonencapsulated,
especially in younger patients. tangled masses of axons, Schwann cells, endoneurial
Younger, healthier patients may choose to undergo cells, and perineurial cells in a dense collagenous
suboccipital craniotomy with microvascular decom- matrix (Figure 8-24).
pression.204 In this major neurosurgical procedure, Etiology. Neuromas tend to develop when a nerve
which in some centers is now performed endoscopical- axon is transected, as might occur with a dental extrac-
ly, an attempt is made to relieve any pressure on the tion, surgery, or trauma. The proximal stump of a tran-
trigeminal sensory root from blood vessels or other sected nerve is still connected to its cell body and, in a
proximal structures. The superior cerebellar artery is few days postinjury, will start to sprout axons, in an
the most common offender because it tends to kink attempt to re-establish continuity with its distal seg-
under the ganglion itself. Muscle or sponge may be used ment. Usually, this process is unsuccessful, especially in
to hold the vessel away from the nerve root. In this way, soft tissue; therefore, a tangled mass of tissue results.219
pain relief may be obtained with no or minimal loss of In the orofacial region, neuromas most commonly
sensation or damage to the fifth cranial nerve.204206 develop in the area of the mental foramen, followed by
For older or medically infirm patients, alternatives the lower lip, tongue, and buccal mucosa, all easily
to gamma knife radiosurgery include injection of glyc- traumatized sites. Neuromas are least likely to occur in
erol into the arachnoid cistern of the gasserian gan- the inferior alveolar canal because the bone guides the
glion or radiofrequency neuroablation of the trigemi- tissue growth.
nal sensory root to destroy A delta and C pain fibers.207 In a seminal research effort, Hansen found neuromas
Both of these procedures involve the percutaneous forming quite routinely in the extraction sockets of the
insertion of a needle through the cheek into Meckels rat alveolus. Four months after extraction, he noted
Difficulty in diagnosis arises when the severe vesicu- matic neuralgia with some success.239 All of the avail-
lar herpetic attack is not manifested but rather one or able therapies may be used individually or in combina-
two small aphthous ulcers appear in the oral cavity or tion with other interventions. In some cases of trigemi-
on the lips or face. This mild attack is often forgotten nal neuropathy, in which peripheral nerve damage has
by the patient, and a careful history is essential.233 resulted in continuous severe pain, electrical stimula-
Treatment. In the future, new vaccines may reduce tion of the gasserian ganglion via an implanted elec-
the overall incidence of chickenpox in the population trode has been shown to provide good pain relief.240
or boost immunity to varicella-zoster virus in middle- Anesthesia Dolorosa. This literally means painful
aged persons, thus preventing the emergence of the anesthesia or pain in a numb area.
virus from its latent phase.234 Although age is the most Etiology. Anesthesia dolorosa is considered a com-
important risk factor for development of this painful plication of deafferentation procedures such as trigem-
chronic disorder, early treatment during the acute inal rhizotomy or thermocoagulation used to treat
phase of herpes zoster with antiviral agents or certain trigeminal neuralgia. It may also follow trauma or
tricyclics (antidepressants), combined with psychoso- damage to the trigeminal nuclear complex or after vas-
cial support, may be effective in preventing the devel- cular lesions of the central trigeminal pathways.54
opment of PHN.235 Although sympathetic nerve Symptoms. Patients complain of pain in an area
blocks do tend to reduce acute herpetic pain, they have that is otherwise numb or has decreased ability to
not been proven to be effective in preventing detect tactile or thermal stimuli. Onset follows deaf-
PHN.231,236,237 ferentation of part or all of the trigeminal nerve, and
Treatment of PHN is often difficult and unreward- the pain typically follows the distribution of the deaf-
ing. The longer the infection continues and the longer ferented branches.
the patient has PHN, the more difficult pain manage- Examination. The painful area is numb or has
ment becomes. Tricyclic antidepressants, gabapentin, diminished sensation to pinprick.
and opioids are the only medications that have shown Treatment. Anesthesia dolorosa is a chronic
efficacy in randomized clinical trials.235 Topical agents intractable pain syndrome70 that is very difficult to
also work238 but are rarely effective alone.235 treat. Centrally acting medications such as tricyclics or
Amelioration of the depression that invariably accom- anticonvulsants may provide some relief.
panies this condition is as significant in therapy as
reduction of the primary pain. 0ur patient, described initially, has com-
Post-traumatic Neuralgias. Traumatic injury to plaints that have characteristics of both the con-
the peripheral nerves often results in persistent dis- tinuous and paroxysmal neuralgias. The constant
comfort that is qualitatively different from PHN. burning pain could be a continuous neuralgia.
Symptoms. The pain is described as a continuous Since there is no history of viral infection or herpes
tingling, numb, twitching, or prickly sensation but zoster outbreak, it is unlikely to be PHN. Since
without the intense, burning hyperesthesia usually seen there is no history of deafferentation procedures,
with PHN or painful neuromas. Onset is following anesthesia dolorosa is also unlikely. However,
damage to the nerve by trauma or surgery. The dis- multiple extractions and repeated dry sockets may
comfort can be self-limited, but total nerve regenera- have resulted in the development of deafferenta-
tion is a slow, inaccurate process and can result in per- tion pain in V2 and V3; it does not explain the
manent dysesthesias or the formation of a neuroma. pain in V1.
Etiology. Peripheral degeneration or scarring of What about the sharp, shooting, electric-like
the nerve may be found on histopathologic examina- pains the patient complained about? These are
tion. Substance P has been implicated as a mediator of reminiscent of trigeminal neuralgia. However, the
the pain, and depletion of this neurotransmitter has temporal pattern is inconsistent. Trigeminal neu-
been shown to reduce the pain. ralgia attacks are over in seconds to minutes; this
Treatment. Treatment of traumatic trigeminal patient complains of pains lasting 30 minutes to
dysesthesias may be met with varying success and can 24 hours. Also, the patient is too young for an idio-
include any of the pharmacologic therapies used for the pathic trigeminal neuralgia, and CT scans have
other neuralgias as well as acupuncture, transcutaneous failed to show any structural lesion that could
electrical nerve stimulation, and hypnosis. Capsaicin, a account for such a pain. Thus, at this point, there
substance P depleter with significant long-term effects, is one possible diagnosis on our differential list,
has been used topically in the treatment of post-trau- namely, post-traumatic deafferentation pain.
CAUSALGIC PAINS region, the bony, vascular, and trophic changes so typi-
Causalgia is a word derived from the Greek words kau- cal in the extremities are less common in the face.248
sos, meaning heat, and algia, meaning pain. Etiology
Causalgia was first described by Mitchell in 1864 as a
pain that appears following damage to a major periph- The exact pathophysiologic mechanisms of RSD are
eral nerve by a high-velocity missile injury.241 unknown. What is known is that after experimental
Consequently, it is typically seen in the extremities. In nerve injury, surviving primary afferent nociceptors
1947, Evans240 used the term reflex sympathetic dys- develop noradrenergic receptors and become sensitive
trophy (RSD) to describe the same burning pain.242 to noradrenalin,233,248,250 as do primary afferents that
He noted that the pain had many features of sympa- are experimentally cut and surgically repaired.251
thetic stimulation such as redness, swelling, sweating, Other experimental studies suggest that some regen-
and atrophic changes in the skin, muscles, and bones. erating primary afferents may anastomose with the
He also found that minor injuries, such as fractures or regenerating postganglionic sympathetic axons that
sprains, could precipitate this pain, not just major run with them.252,253 Post-traumatic sympathetic-
nerve trauma. That same year, Bingham published the afferent coupling also appears to occur in the dorsal
first report of RSD of the face.243 root ganglion where sympathetic fibers that innervate
Today RSD and, in particular, causalgia are consid- the vasculature subserving the dorsal root ganglion
ered the most dramatic forms of a class of pains called begin to sprout around the primary afferent
sympathetically maintained pains (SMPs), RSD occur- fibers254,255 (Figure 8-26).
ring without and causalgia with a definable nerve lesion. Clinically, the sympathetic nervous system is impli-
Because the exact contribution of the sympathetic nerv- cated in these pains because sympathetic blockade pro-
ous system to RSD and causalgia is still under investiga- vides profound relief, and electrical stimulation of
tion, an effort was made in the mid-1990s to rename sympathetic outflow makes the pain worse.256 Neither
these types of pain disorders as complex regional pain of these conditions exists in a normal individual.
syndromes, type I and type II, respectively.244 These Changes in central pain pathways are also implicated in
terms eliminate the implied causal association of the the RSD picture.3
sympathetic nervous system to these pain disorders. This
Examination
terminology, along with clinical criteria, was included in
the second edition of the IASP Classification of Chronic The patient with causalgia/RSD complains of pain at
Pain Syndromes but has shown marginal reliability the slightest touch and is difficult to examine. The skin
when tested clinically,245,246 and the terms SMP, RSD, may be flushed and dry or cold and sweaty, and a tem-
and causalgia continue to be used. perature difference may be discernible.
Figure 8-26 Influence of sympathetic activity and catecholamines on sensitized and damaged primary afferents. Normally primary affer-
ent neurons do not have catecholamine sensitivity, and their activity is unaffected by sympathetic outflow. After nerve lesion (1) or in the
presence of inflammation, afferent terminals in the periphery or afferent somata in the dorsal root ganglion acquire sensitivity to noradren-
aline (NA) by expressing -receptors at their membrane. Activity in postganglionic sympathetic neurons is now capable of activating affer-
ent neurons by the release of NA. In addition, sympathetic postganglionic neurons sprout around dorsal root ganglion cells (2). Reproduced
with permission from Fields HL, Rowbotham M, Baron R. Neuralgia: irritable nociceptors and deafferentation. Neurobiol Dis 1998;5:209.7
and relaxation techniques may help reduce generalized and mouth is initially to assume that the pain is dental
sympathetic activity. Transcutaneous electrical nerve until proved otherwise, then muscular until proved
stimulation or acupuncture in combination with physi- otherwise.70 Myospasm, myositis, and myofascial TrP
cal therapy may be helpful in providing relief and pain will be discussed as part of this group (Table 8-
increasing function. Surgical removal of the upper sym- 13). Local myalgia unclassified includes muscle
pathetic chain is the last resort procedure when all else splinting, which is grouped with other muscle disor-
has failed. If an inadequate sympathectomy is per- ders such as delayed-onset muscle soreness or pain
formed, the pain may return. owing to ischemia, bruxism, or fatigue. This is because
there are few clinical characteristics that differentiate
Our patient complains of pain with many of these muscle disorders from each other.61
the characteristics described for RSD and causal-
gic pain. The pain has a burning quality. The Myospasm
skin is hypersensitive. The affected side of the Etiology. Myospasm, involuntary continuous
face is warmer to touch and slightly swollen. The contraction of a muscle or group of muscles, may occur
pain is made worse with any type of stimulation. owing to acute overuse, strain, or overstretching of
She has a history of tooth extraction with alveo- muscle previously weakened through protective reflex
lar osteitis (dry socket). Reflex sympathetic dys- contraction (see Figure 8-11). Commonly termed a
trophy of the face is definitely worth listing as a charley horse, muscle spasm may occur, for example,
possible diagnosis. after sustained opening of the patients mouth for den-
tal treatment. Deep pain input from other sources such
When dealing with any neuropathic or sympatheti- as joint inflammation, dental infection, or myofascial
cally maintained pain, referral to a neurologist should TrPs may also result in reflex spasm of associated mus-
be considered if there are any subjective complaints or
objective findings of cranial nerve deficits such as areas
of facial hypesthesia, persistent motor weakness or Table 8-13 Muscular Pains
paralysis, or a depressed corneal reflex. Myospasm pain
MUSCULAR PAINS Myositis pain
Local myalgiaunclassified
Pain of muscular origin is generally described as a con- Myofascial pain
tinuous, deep, dull ache or as tightness or pressure. It is Tension-type headaches
undoubtedly the most prevalent cause of pain in the Coexisting migraine and tension-type headaches
head and neck region.62,63,258 According to Bell, a
good rule to follow in diagnosing pains about the face Adapted from Okeson.61
cles. In the absence of an obvious etiology, patients Symptoms. Characteristically, the patient com-
should be questioned regarding medication use. plains of continuous pain over the muscle aggravated
Medications such as Compazine (prochlorperazine) by jaw opening, limited jaw opening, and swelling over
and Stelazine (trifluoperazine) or other major tran- the involved muscle. There is usually a history of trau-
quilizers may cause muscle spasm. Prolonged use of ma or infection. If the cause is attributable to infection,
this type of medication may also result in tardive dysk- the patient may also complain of malaise and fever.
inesia, an irreversible condition consisting of involun- Examination. Myositis can be distinguished from
tary movement of the tongue and/or lips. myospasm owing to the presence of swelling. The mus-
Symptoms. An acutely shortened muscle with cle is diffusely tender. Mandibular range of motion is
gross limitation of movement and constant pain is severely restricted. Regional lymphadenitis is present if
characteristic. The pain has a dull, aching quality with there is infection.
occasional sharp, lancinating pains in the ear, temple, Treatment. Treatment of both myositis and con-
or face. Depending on which muscles are involved, tracture is similar to that used for myospasm, except
acute malocclusion may result. Patients may complain that NSAIDs are also recommended. Exercises, mas-
of increased pain on chewing or functioning of the sage, and injections are contraindicated until acute
spastic muscle. Headache may also result. symptoms have subsided.
Examination. A normal jaw opening of 40 to 60 mm
may be reduced to 10 to 20 mm with spasm. Maloc- Local MyalgiaUnclassified
clusion and abnormal jaw opening may be evident. Myospasm and myositis present with specific charac-
Diagnostic Tests. Electromyography (EMG), sur- teristics that allow a definite clinical distinction to be
face, needle, or fine wire, will show substantially increased made. Other kinds of myalgias owing to ischemia, mus-
muscle activity even at rest.61,259 Injection of suspected cle overuse (fatigue and postexercise muscle soreness),
muscles with plain 0.5% or 1% procaine or lidocaine or protective splinting or co-contraction also exist.
should provide relief and confirm the diagnosis. However, currently, there is little scientific information
Treatment. If left untreated, the pain will subside. to allow clear distinction between these disorders, and
However, as a result of decreased function, there is a for this reason they are grouped together as unclassified
risk of developing contracture. Many episodes of lock myalgias.61
jaw and torticollis (wry neck) are attributable to con-
tracture. Therefore, patients should continue to use the Myofascial Pain
jaw within pain-free limits. Heat may provide sympto- Myofascial pain, a regional referred pain syndrome
matic relief. As the pain decreases, gradual active associated with focally tender TrPs in muscle, is a
stretching of the muscle over a period of 3 to 7 days, prevalent cause of pain in all parts of the body and has
with simultaneous application of counterstimulation been reported as a common source of pain in numer-
or injection of the muscle with a weak solution of plain ous medical specialties.62,64 For example, almost 30%
procaine or lidocaine, may facilitate restoration of nor- of patients presenting themselves with a complaint of
mal function. pain in an internal medicine practice62 and over 80% of
patients in a chronic pain center64 had MFP as a pri-
Myositis mary diagnosis. It is also the most prevalent cause of
Myositis is inflammation of muscles that, in the head painful symptoms in TMDs.63,258
and neck region, most frequently involves the masseter In a study conducted at the University of Minnesota
and medial pterygoid muscles. According to Bell, the TMJ and Facial Pain Clinic, doctors evaluated 296 con-
familiar trismus [our emphasis added] associated with secutive patients with chronic head and neck pain
dental sepsis, injury, surgery, or needle abscess typifies complaints.258 Myofascial pain was the primary diag-
this condition.70 nosis in 55.4% of these patients. Nonpainful internal
Etiology. Myositis is usually the result of external derangements of the TMJs were felt to be a perpetuat-
trauma (eg, contact sports), excessive muscle overuse, or ing factor to the MFP in 30.4%. In contrast, only 21%
spreading infection (eg, dental abscess).70,260 In fact, of these patients had a TMD disorder as the primary
many of the same things that cause myospasm may cause cause of pain. In this 21%, the joint disorder included
myositis if prolonged or severe enough. The associated inflammation of the TMJ joint capsule or the retrodis-
mandibular dysfunction is related to pain and to the pres- cal tissues.
ence of inflammatory exudate in the muscles. Myositis Despite its prevalence and the recent surge in scientif-
may progress to fibrous scarring or contracture.70,260 ic documentation, MFP remains poorly understood and
frequently unrecognized by most health care providers. Secondary MFP may prolong and complicate pain
Many physicians and dentists alike insist on calling it owing to other causes.261 Examples include migraine,
myofacial pain and think of it as a myalgia of the facial inflammatory disorders of the TMJ, chronic ear infec-
muscles and masticatory muscles. Others feel that it is a tions, persistent pulpalgia, PHN, cancer, or any other
syndrome that involves some internal derangement of chronic painful condition including bursitis of the ten-
the TMJ plus associated local muscle soreness. sor villi palatini muscle as it passes over the hamu-
Symptoms. In MFP, the presenting pain com- lus.261,267 Myofascial pain needs to be identified and
plaint is usually a referred symptom with a deep, dull treated to reduce pain and improve response to other
aching quality located in or about normal muscular or, therapies. Patients with what appears to be primary
importantly, nonmuscular structures. In the head and MFP, in whom TrPs and pain recur despite appropriate
neck region, the patient may complain of such things as initial response to TrP therapies and compliance to
toothache, sinus pain, TMJ pain, or headache, yet eval- home exercise, must be re-evaluated for occult under-
uation of these areas does not yield any pathologic lying disease or other perpetuating factors.
change. In fact, any undiagnosed deep, dull, aching pain In MFP, the presenting pain complaint is always
may be myofascial in origin. The intensity of MFP associated with a TrP located in a taut band of skeletal
should not be underestimated: the pain intensity has muscle that is often distant from the site of pain.
been documented to be equal or slightly greater than Trigger points are focally tender, firm, nodular areas in
that of pain from other causes.62 muscle, that, with the application of 2 to 4 kg of pres-
Associated symptoms, thought to be owing to the sure for 6 to 10 seconds, produce spontaneous referred
physiologic sensory, motor, and autonomic effects seen pain or intensify existing pain in local or distant loca-
with prolonged pain, are common and may confuse the tions.268 Patients are typically unaware of the existence
clinical picture.261263 These effects were discussed ear- of these TrPs. Trigger points are considered active when
lier in the section under Neurophysiology of Pain. the referred pain pattern and associated symptoms are
Associated sensory complaints may include tenderness clinically present and latent when they are not. Trigger
in the referred pain site, such as scalp pain on brushing points will vacillate between active and latent states
the hair, or abnormal sensitivity of the teeth.264 Motor depending on the amount of psychological stress the
effects include increased EMG activity in the pain ref- individual is under and the amount of muscle overload
erence zone,262,263,265,266 although patients rarely com- placed on the affected muscle.
plain about this specifically. Autonomic changes such The location of TrPs and their associated referred
as localized vasoconstriction (pallor),262 sweating, pain patterns are predictable and reproducible from
lacrimation, coryza, increased salivation, and nausea patient to patient55,269271 (Figures 8-27 to 8-30). A
and vomiting have also been reported.55 meticulous discussion of MFP, as well as a complete
Patients note worsening of symptoms with increased compendium of the pain referral patterns for most
psychological stress, cold weather, immobility, and muscles of the body, has been brilliantly detailed by
overuse of involved muscles. Hot baths, rest, warm Travell and Simons.55,271
weather, and massage are typical alleviating factors. Pathophysiology. With some training, myofascial
Etiology. Myofascial TrPs can be primary or sec- TrPs are relatively easy to palpate. Despite the compar-
ondary. When primary, injury to the muscle owing to ative ease of clinical identification of TrPs, controversy
macrotrauma or cumulative microtrauma is typically still exists about their structure and exact pathophysi-
involved. Macrotrauma is easily identified and includes ology. Muscle biopsy studies using light and electron
injuries such as those caused by falls, blows, sports microscopy, as well as histochemical analyses, have not
injuries, motor vehicle accidents, or even prolonged shown consistent abnormalities, and there is no evi-
jaw opening at the dental office. Microtrauma is more dence for inflammation.272,273 However, careful
insidious and includes muscle overuse owing to poor monopolar needle EMG evaluation has revealed some
posture and body mechanics, abnormal strain, and interesting information.
repetitive motiontype injuries. Although EMG findings in the muscle surrounding
Secondary myofascial TrPs develop in response to the TrP are normal, higher EMG microvoltages, called
prolonged underlying disease, especially if painful, for spontaneous electrical activity or SEA, are found
which any process that activates nociceptors may in the TrPs themselves.274 Spontaneous electrical
induce secondary muscle contraction and TrP develop- activity is significantly higher in subjects with clinical
ment (described under Physiologic Mechanisms pain owing to active TrPs than in subjects without
Modifying Pain at the beginning of this chapter). clinical pain who have latent or no TrPs. Spontaneous
A B
C D
Figure 8-27 Referred pain patterns from trigger points (crosses) in the temporalis muscle (essential zone, black; spillover zone, stippled).
A, Anterior spokes of pain arising from anterior fibers (trigger point, TP1). Note reference to anterior teeth. B and C, middle spokes of
TP2 and TP3 referring to maxillary posterior teeth, sinus, and zygomatic area. D, Posterior, TP4, supra-auricular spoke referral. Reproduced
with permission from Simons DG et al.55
electrical activity can be recorded only if the needle is Muscle spindles are 1.5 mm 5 mm mechanorecep-
precisely placed in the nidus of the TrP; movement of tors that signal muscle length. They are found between
the needle tip as little as 1 mm is enough to lose the and parallel to skeletal muscle fibers and are more
signal. Spontaneous electrical activity has been inter- numerous in the cervical and axial muscles, where TrPs
preted by Hubbard and others as arising from muscle more commonly occur.52,277 They contain intrafusal
spindles274,275; Simons et al. and Hong and Simons fibers that are innervated by the sympathetic nervous
believe that dysfunctional muscle motor end plates system and are pain and pressure sensitive.
are to blame.55,276 Psychological stress, which causes increased sympa-
A B
C D
Figure 8-28 Central and referred pain from the masseter muscle. The crosses locate trigger points in various parts of the masseter; the black
areas show essential referred pain zones and stippled areas are spillover pain zones. A, Superficial layer, upper portion. Note reference to max-
illary posterior teeth. B, Superficial layer, midbelly. Note spillover reference to mandible and posterior teeth. C, Superficial layer; lower por-
tion refers to the mandible and frontal headache. D, Deep layer; upper part refers to the temporomandibular joint area and ear. Reproduced
with permission from Simons DG et al.55
thetic output, has been shown to increase the SEA curare and botulinum toxin, postsynaptic and presy-
recorded from TrPs, whereas the EMG activity of adja- naptic cholinergic blockers, respectively, have no effect
cent non-TrP sites remains unchanged.275 These data on SEA in randomized, controlled studies.274,279 A soli-
parallel the clinical observation that emotional stress tary human EMG-guided biopsy specimen contained a
activates or aggravates pain from TrPs and supports the single muscle spindle (Figure 8-31).
spindle hypothesis of TrPs. Similarly, intramuscular or The existence of afferent pain receptors in muscle
intravenous administration of sympathetic blocking spindles does provide an explanation for TrP palpation
agents effectively abolishes the SEA,274,277,278 whereas tenderness. Hubbard and Shannon argued that based
A B
nodule is described as a group of contraction knots in The mechanism of referred pain from myofascial
which a number of individual muscle fibers are maxi- TrPs is also under speculation. According to Mense28
mally contracted at the end-plate zone, making them and Vecchiet et al.,287 the convergence-projection and
shorter and wider at that point than the noncontracted convergence-facilitation models of referred pain
neighboring fibers. If enough fibers are so activated, a (described earlier under Referred Pain) do not direct-
palpable nodule could result. As for the taut band, both ly apply to muscle pain because there is little conver-
ends of these affected muscle fibers would be maximal- gence of neurons from deep tissues in the dorsal
ly stretched out and taut, producing the palpable taut horn.28 These authors propose that convergent connec-
band (Figure 8-32). tions from other spinal cord segments are unmasked
Clinically, data exist documenting that TrPs are truly or opened by nociceptive input from skeletal muscle
focally tender areas in muscle; pain with palpation is and that referral to other myotomes is owing to the
not owing to generalized muscle tenderness.282,283 release and spread of substance P to adjacent spinal
Indeed, tenderness to palpation over non-TrP sites in segments28,288 (see Figures 8-6 and 8-7). Simons has
subjects with MFP does not differ significantly from expanded on this theory to specifically explain the
normals.282 Also, muscle bands containing TrPs will referred pain from TrPs30 (see Figure 8-9).
display a local twitch response, a transient contraction The following is an excellent example of myofascial
of the muscle band with deep snapping digital palpa- TrP pain developing in response to an acutely
tion. This response, best appreciated in more superfi- inflamed TMJ.
cial muscle fibers, has also been substantiated experi-
mentally.284 A rabbit model of the twitch response has Case History
documented that, at least in rabbits, the twitch A 47-year-old man with a long-standing history
response is a spinally mediated reflex.285,286 of painless osteoarthrosis of both TMJs presented
A B
Figure 8-35 Muscle palpation for myofascial
trigger points. A, Flat fingertip palpation of mas-
seter muscle looking for taut bands and focal ten-
derness characteristic of myofascial trigger points.
The flat palpation technique is also useful for tem-
poralis, suboccipital, medial pterygoid, and upper
back muscles. B, Pincer palpation of the deep
clavicular head of the sternocleidomastoid muscle.
C, Pincer palpation of the superficial sternal
head. Heads should be palpated separately. The
upper border of the trapezius also lends itself to
pincer palpation.
cular headaches. These patients have varying degrees pain. Myofascial TrP pain is clearly under-recog-
of each of these two headache types. Typically, they nized,301,302 and trigeminal neuropathies or dysesthe-
complain of dull, aching, pressing head pain that pro- sias, which many believe to be at fault for various
gresses into a throbbing headache. This type of atypical facial pains, are still inadequately under-
headache has an even higher incidence of pericranial stood.301 Although proposals for nomenclature and
muscle tenderness and referred pain than tension- classification changes abound,301303 this atypical
type headache.136 Treatment requires management of nomenclature is likely to haunt the dental/orofacial
the MFP as well as judicious use of abortive or pro- pain profession for several years to come.
phylactic migraine medications. Two types of atypical pain that commonly appear in
the dental office are atypical odontalgia (idiopathic
Although our patient did not complain specifi- toothache, phantom odontalgia,303 or trigeminal dyses-
cally of deep, aching pains, secondary MFP does thesia) and burning mouth syndrome (Table 8-14).
occur with most types of chronic pain input into Although deafferentation (neuropathic pain) is believed
the central nervous system. Therefore, it is likely to play a role in both of these pain syndromes, the mech-
that secondary myofascial TrPs have developed. In anism and etiology are still largely speculative.
fact, when the patient was initially examined, Therefore, it is as yet difficult to reliably classify them
TrPs were found in the upper trapezius muscle under any of the diagnostic categories already discussed.
that referred pain to the side of the temple and
face (see Figure 8-36). Even if this is not the pri- Atypical Odontalgia
mary cause of the pain, it is likely to be a con- In 1979, Rees and Harris described a disorder they
tributing factor. called atypical odontalgia.304 Synonymous or almost
synonymous terms include phantom tooth pain,303
UNCLASSIFIABLE PAINS/ idiopathic orofacial pain,305 vascular toothache,70
ATYPICAL FACIAL PAINS and, more recently, trigeminal dysesthesia. Patients
Mock et al. have stated, The diagnoses atypical facial present with chronic toothache or tooth site pain with
pain and atypical facial neuralgia are often applied inter- no obvious cause. It is extremely important for den-
changeably to the patient with poorly localized, vaguely tists to be aware of the existence of this syndrome to
described facial pain, nonanatomic in distribution with avoid performing unnecessary dental procedures and
no evidence of a defined organic cause.299 Technically, extractions. It has been postulated that as many as 3 to
these are not atypical pains but idiopathic pains, pains 6% of endodontic patients may suffer from this type
for which we do not yet have a diagnosis or sufficient of tooth pain, especially if they had pain prior to pulp
understanding. Yet if we look at retrospective analysis of extirpation.303
data collected on 493 consecutive patients who present- Symptoms. The chief complaint is a deep, dull,
ed to a university orofacial pain clinic, a different picture aching pain in a tooth or tooth site that is unchanging
emerges.300 A diagnosis of atypical facial pain was made over weeks or months. The pain is fairly constant, with
if patients had persistent orofacial pain for more than 6 some diurnal fluctuation, and usually worsens as the
months for which previous treatments had been unsuc- day progresses. The molars are most commonly
cessful and the diagnosis was unknown on referral to the involved, followed by premolars. Anterior teeth and
clinic. Of the 493 patient charts reviewed, 35 (7%) met canines are less frequently affected.306 The vast majori-
these criteria. Using the American Academy of Orofacial ty of patients present themselves with unilateral pain,
Pain diagnostic criteria,61 all but 1 (97%) had diagnos- although other quadrants may become involved and
able physical problems and sometimes multiple overlap- other oral and facial sites may hurt.
ping physical diagnoses causing the pain. Over half (19 Most patients are female and over 40 years of age.
of 35 or 54%) were found to have MFP owing to TrPs as Table 8-15 lists the clinical characteristics of patients
a primary cause or significant contributing factor to the with atypical odontalgia as reported by several different
pain. Eleven (31%) had periodontal ligament sensitivity, authors. Onset of the pain may coincide with or devel-
8 had referred pain from dental pulpitis, 3 had neuro-
pathic pain, and 1 each had burning mouth from oral
candidiasis, sinus pathology, burning tongue from an Table 8-14 Unclassifiable Pains
oral habit, pericoronitis, or an incomplete tooth fracture.
Atypical odontalgia
There is currently significant controversy in the field
Burning mouth syndrome
about the diagnosis and classification of atypical facial
Table 8-15 Clinical Characteristics of Patients with painful tooth is extracted. In addition, the preponder-
Atypical Odontagia* ance of females suffering from this disorder raises the
question of the role of estrogen and other female hor-
N = 30
mones as a risk factor in atypical odontalgia and relat-
Age 58.4 y
ed idiopathic orofacial pains.315
Duration 4.4 y
Examination. Intraoral and radiographic exami-
90% female
nation are typically unrevealing. If the pain is in a tooth
*Seen at the University of Florida College of Dentistry.309 as opposed to an extraction site, responses to percus-
sion, thermal testing, and electric pulp stimulation are
variable. Clinically, there is no observable cause, yet
op within a month or so after dental treatment (espe- thermographic evaluation is always abnormal.316 The
cially endodontic therapy or extraction) or trauma or majority of patients report little or no relief with diag-
medical procedures related to the face.303 Patients may nostic local anesthetic blocks,306,317 although sympa-
have a history of repeated dental therapies that have thetic blocks seem to be helpful.306
failed to resolve the problem. Chewing or clenching on Treatment. Invasive, irreversible treatments, such
painful teeth, heat, cold, and stress are typical but as endodontic therapy, exploratory surgery, extraction,
inconsistent aggravating factors. or even occlusal adjustments, are contraindicated.303,317
Etiology. The true etiology of atypical odontalgia This is because, despite possible transient relief, the pain
remains elusive. Bell classified it as a vascular disorder,70 is likely to recur with equal or greater intensity.
as did Rees and Harris, who postulated a painful The current treatment of choice is the use of tri-
migraine-like disturbance in the teeth and periodontal cyclic antidepressant agents such as amitriptyline or
tissues, possibly triggered by depression.304 There are no imipramine.303,306,317 If the pain has a burning quality,
data to support this idea, although a study using subcu- the addition of a phenothiazine, such as trifluoper-
taneous sumatriptan in 19 atypical facial pain patients azine, may be helpful.303,317 Tricyclic antidepressants
did show some small temporary positive effects, possi- have analgesic properties independent of their antide-
bly supporting a vascular contribution to the pressant effects and often provide good pain relief at a
pain.307,308 Others have suggested depression or some fraction of the dose typically used to treat depres-
other psychological disorder as the cause309,310 since sion.312,318 Pain relief normally occurs at doses from 50
many patients with atypical odontalgia report depres- to 100 mg. Dry mouth is an expected and usually
sive symptoms on clinical interview.303,311,312 However, unavoidable side effect. A history of significant cardiac
these results must be questioned owing to poor, uncon- arrhythmias or recent myocardial infarction, urinary
trolled study methodology and because there is a gener- retention, and glaucoma are contraindications for the
ally higher incidence of depression in patients with use of tricyclic medications because of their atropine-
chronic pain. Of interest is the fact that standard MMPI like action. Patients may need reassurance that the pain
scores for patients with atypical odontalgia compared is real and not psychogenic but that invasive proce-
with standard scores for a chronic headache group dures will not help.
(matched for age, sex, and chronicity) were similar, and If a patient complains of associated gingival hyper-
scales for both groups were within normal ranges,306,313 esthesia, use of topical agents such as local anesthetic or
making a psychological cause unlikely. capsaicin have been shown to be beneficial.314
A more probable cause of atypical odontalgia is Unwanted stimulation of the area can be reduced by
deafferentation (partial or total loss of the afferent construction of an acrylic stent that can also be used to
nerve supply or sensory input) with or without sympa- help apply any topical medication.
thetic involvement. Atypical odontalgia usually fol-
lows a dental procedure, and most dental procedures, Burning Mouth Syndrome
including cavity preparation, cause varying degrees of Burning mouth syndrome is an intraoral pain disorder
deafferentation. Studies supporting this theory are also that most commonly affects postmenopausal women.
lacking, yet the symptoms and clinical presentation are The National Institutes of Dental and Craniofacial
consistent with post-traumatic neuropathic pain. Many Research (NIDCR) report on the national Centers for
cases respond to sympathetic blocks306 or phento- Disease Control household health survey stated that
lamine infusion,314 implying that at least some may be 1,270,000 Americans (0.7% of the US population) suf-
sympathetically mediated or maintained. This theory fered from this disorder.81 When it primarily affects the
would also explain why the pain remains even after the tongue, it is referred to as burning tongue or glossody-
nia. Grushka and her colleagues have conducted sever- Examination. The patient with burning mouth
al studies to systematically characterize the features of syndrome generally has a negative intraoral examina-
this syndrome.319322 tion. Obvious tissue-irritating causes such as denture
Symptoms. Patients complain of intraoral burn- soreness, rough crowns or teeth, and other causes of
ing, the tip and sides of the tongue being the most com- tissue irritation such as candidiasis or true vitamin
mon sites, followed by the palate. Dry mouth, thirst, deficiencies must, of course, be ruled out.
taste and sleep disturbances, headaches, and other pain Tests. Candidiasis should be tested for even if the
complaints are frequently associated symptoms. Onset mucosa looks normal. Local anesthetic rinse will
is often related to a dental procedure. The intensity of decrease the pain of other conditions such as geograph-
pain is quantitatively similar to that of toothache, ic tongue or candidiasis but increase the pain of burn-
although the quality is burning rather than pulsing, ing mouth. This increase in pain is thought to be owing
aching, or throbbing. The pain increases as the day pro- to further loss of A beta fiber inhibition. Sedimentation
gresses and tends to peak in early evening. Patients with rate may be mildly elevated, and, in view of the higher
burning mouth syndrome may complain of sponta- incidence of immunologic abnormalities, rheumatolog-
neous tastes or taste phantoms (dysgeusia).323 ic evaluation should be considered.
Etiology. There are many obvious oral and sys- Treatment. Studies assessing therapeutic outcome
temic conditions that are associated with mucogingival are lacking. Low-dose tricyclic antidepressants, such as
and glossal pains. These include candidiasis, geographic amitriptyline, have had some success,324 but newer
tongue, allergies to dental materials, denture dysfunc- open label studies suggest that clonazepam, both orally
tion, xerostomia, various anemias and vitamin deficien- and topically, may be more useful.329,330 Topical appli-
cies (iron, vitamin B12, or folic acid), diabetes mellitus, cation of 0.5 or 1 mg clonazepam two or three times
several dermatologic disorders (lupus, lichen planus, daily provided complete to significant relief in 19 of 25
erythema multiforme), human immunodeficiency patients.330 Orally, low (0.25 to 0.75 mg) daily doses of
virus, or systemic medications (either directly or indi- clonazepam provided relief for 70% of 30 patients.329
rectly through resultant xerostomia).81,324 However, in Addition of low doses of valproic acid or imipramine
burning mouth syndrome, controlled studies have doc- may be useful if more pain relief is required.329
umented that the oral mucosa appears normal, and no
obvious organic cause can be identified.322 There is evi- The pain our patient complains of has none of
dence for a higher incidence of immunologic abnor- the characteristics of either atypical odontalgia or
malities in burning mouth syndrome patients than burning mouth syndrome except for the burning
would be expected in a normal population, and several quality. It is therefore unlikely that these diag-
burning mouth syndrome patients have been shown to noses are causing her pain.
have Sjgrens syndrome.319 Thus, we have the following differential:
Recent research supports the following theory on
the etiology of pain and phantom tastes in burning 1. Rule out reflex sympathetic dystrophy (sym-
mouth syndrome patients. The special sense of taste pathetically maintained pain) of the left side
from the tongue is mediated by cranial nerves VII of the face.
(anterior two-thirds) and IX (posterior one-third). 2. Rule out post-traumatic neuralgia of cranial
Cranial nerve VII innervates the fungiform papillae of nerve V1V3 on the left.
the tongue, which, in turn, are surrounded by pain 3. Myofascial TrP pain is likely to be contribut-
fibers from cranial nerve V. Cranial nerve VII normally ing to the pain complaint.
inhibits both cranial nerve V (pain fibers) and cranial 4. There is internal derangement of the left
nerve IX (taste). Damage or partial deafferentation of TMJ with questionable contribution to the
cranial nerve VII appears to release inhibition of both total pain complaint.
cranial nerves V and IX, producing both pain and taste
phantoms, respectively.324,325 How can one differentiate between 1 and 2?
Burning mouth syndrome is not to be confused with Sensory blocks of the trigeminal nerve in the past
postmenopausal oral discomfort, which has a burning have provided temporary but not long-lasting
component. In the latter condition, estrogen replace- relief. In fact, the pain returned with the return of
ment therapy is effective about half of the time.326 sensation. To differentiate between a purely sen-
Psychological factors, although present in some of sory neuralgia and RSD (sympathetically main-
this population, do not appear to be etiologic.327,328 tained pain), the definitive test is a stellate gan-
glion block. This will provide dramatic relief if the health professionals to coordinate patient care and to
pain is sympathetically mediated and no relief if it provide a comprehensive healthy environment for reha-
is owing to a neuralgia. bilitation. Chronic pain management, including orofa-
Left sympathetic stellate ganglion block does cial pain, has become a growing specialty in health care.
indeed relieve this patients pain, and the pain It takes years of training and experience to gain adequate
relief outlasts the duration of the local anesthetic. insight into these complex cases. Several dental schools
Although the patient is pain free, it is possible to across the United States now offer 2-year postgraduate
complete a thorough musculoskeletal examina- orofacial pain programs to train interested dentists in
tion. Range of motion is restricted in the left TMJ, the field of orofacial pain. Dentists with competence in
with deviation of the jaw to that side on opening. this field can be identified by contacting the American
At 30 mm of mandibular depression, a loud crack Board of Orofacial Pain. This organization awards diplo-
is audible, and the patient is able to open wider. mate status to qualified dentists who pass their certifica-
Active myofascial TrPs that refer pain into the tion examination. Orofacial pain dentists, armed with
forehead and along the side of the face are found knowledge, interest, curiosity, and patience, and, finally,
in the upper trapezius, masseter, and lateral the instruments of diagnosis, enjoy a most rewarding
pterygoid muscles. experienceidentifying the source of pain and relieving
Management of this patients pain will require the suffering of a fellow human being. The orofacial pain
repeated sympathetic blockade to control the sym- dentist, oriented toward looking at the patient as a whole
pathetically maintained pain. In addition, pos- person, can gain much satisfaction from arriving at a
tural and stretching exercises, along with an intra- correct diagnosis and saving teeth or preventing unnec-
oral stabilization splint, are indicated to reduce essary surgery.
the MFP and stabilize the left TMJ. Spray and The complex and personal nature of good diagnosis
stretch, TrP pressure release, and/or TrP injections cannot be overemphasized. This is the area in which the
may facilitate the resolution of the MFP even fur- dentist is most likely, on a professional basis, to earn the
ther. Ultimately, dental treatment to restore left respect and friendship of his colleagues, both dental
posterior dental support is indicated. Stress man- and medical, as well as that of his patients.
agement and relaxation training may further help
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Chapter 9
PREPARATION FOR
ENDODONTIC TREATMENT
John I. Ingle, Richard E. Walton, Stanley F. Malamed,
Jeffrey M. Coil, John A. Khademi, Frederick H. Kahn,
Barnet B. Shulman, James K. Bahcall, and Joseph T. Barss
Before the actual operative aspects of root canal thera- I was attempting to fill the root canal of an upper cen-
py are begun, a number of preparatory procedures tral incisor, Kells later said. It occurred to me to place a
must first be completed: lead wire in this root canal and then take a radiogram to
see whether it extended to the end of the root or not. The
1. Radiography is needed, first as an aid to diagnosis, lead wire was shown very plainly in the root canal.
then periodically during treatment. Endoscopy, One year later (1900), Dr. Weston A. Price called
orascopy, and the surgical microscope are supple- attention to incomplete root canal fillings as evidenced
mental aids to visual enhancement. in radiographs. By 1901, Price was suggesting that
2. Specialized endodontic instruments and equipment radiographs be used to check the adequacy of root
must be arranged for ready use. canal fillings.2 Price is also credited with developing the
3. Local anesthesia of the involved tooth or area may be bisecting angle technique, whereas Kells described what
necessary. Special problems of anesthesia also may today is called the paralleling technique, made popular
arise, particularly with mandibular molars and in some 40 years later by Dr. Gordon Fitzgerald.
the case of an inflamed pulp. Although these early attempts were rarely of diag-
4. Rubber dam placement sometimes requires special nostic quality, they were the beginning of a new era for
handling in endodontics. all of dentistry. For the first time, dentists could see the
accumulation of past dental treatment therapy done
ENDODONTIC RADIOGRAPHY* without knowledge of what lay beneath the gingiva.
No single scientific development has contributed as Needless to say, the calamitous findings must have dis-
greatly to improved dental health as the discovery of the heartened the conscientious practitioner. Yet even
amazing properties of cathode rays by Professor today, with all of the modern engineering refinements,
Wilhelm Konrad Roentgen in November 1895. The sig- the sleekness of operation, and the reduction of haz-
nificant possibilities of their application to dentistry ards, a discouraging segment of our profession contin-
were seized upon 14 days after Roentgens announce- ues to deprive the public by failing to use radiography
ment, when Dr. Otto Walkoff took the first dental radi- to its full potential.
ograph in his own mouth.1 In the United States, within The total application of roentgen rays and the disci-
5 months, Dr. William James described Roentgens plined interpretation of the product are beyond the
apparatus and displayed several radiographs. Three scope of this textbook. Only the utilization of radiogra-
months later, Dr. C. Edmund Kells gave the first clinic in phy in endodontics will be discussed here. Suffice it to
this country on the use of the x-ray for dental purposes. say that radiography is absolutely essential for root
Three years later (1899), Kells was using the x-ray to canal therapy.
determine tooth length during root canal therapy.
Application of Radiography to Endodontics
The roentgen ray is used in endodontic therapy to (1)
*Abstracted in part from Walton RE.27 aid in the diagnosis of hard tissue alterations of the
teeth and periradicular structures; (2) determine the dimension is absent on a single film and is frequently
number, location, shape, size, and direction of roots forgotten, although techniques are available to define
and root canals; (3) estimate and confirm the length of the third dimension. These techniques are described
root canals before instrumentation; (4) localize later in detail.
hard-to-find, or disclose unsuspected, pulp canals by Radiographs are not infallible. Various states of pul-
examining the position of an instrument within the pal pathosis are indistinguishable in the x-ray shadow.
root (Figure 9-1); (5) aid in locating a pulp that is Neither healthy nor necrotic pulps cast an unusual
markedly calcified and/or receded (Figure 9-2); (6) image. Correspondingly, the sterile or infected status of
determine the relative position of structures in the hard or soft tissue is not detectable other than by infer-
faciallingual dimension; (7) confirm the position and ence. Only bacteriologic evidence can determine this.
adaptation of the primary filling point; (8) aid in the Furthermore, periradicular soft tissue lesions cannot be
evaluation of the final root canal filling; (9) aid in the accurately diagnosed by radiographs; they require his-
examination of lips, cheeks, and tongue for fractured tologic verification. Chronic inflammatory tissue can-
tooth fragments and other foreign bodies (except plas- not, for example, be differentiated from healed, fibrous,
tic and wood) following traumatic injuries; (10) aid in scar tissue, nor can a differential diagnosis of peri-
localizing a hard-to-find apex during periradicular sur- radicular radiolucencies usually be made on the basis
gery; (11) confirm, following periradicular surgery and of size, shape, and density of the adjacent bone.37 A
before suturing, that all tooth fragments and excess fill- common misconception is that an inflammatory lesion
ing material have been removed from the apical region is present only when there is at least a perceptible
and the surgical flap; and (12) evaluate, in follow-up thickening of the periodontal ligament space. In fact,
films, the outcome of endodontic treatment. investigators have demonstrated that lesions of the
medullary bone are likely to go undetected until the
Limitations of Radiographs resorption has expanded into and eroded a portion of
Radiographs have their limitations! They are sugges- the cortical plate.811
tive only and should not be considered the singular The difficulties and inherent errors in radiographic
final evidence in judging any clinical problem. There interpretation were clearly demonstrated by Goldman
must be correlation with other subjective and objective et al.,12 who submitted recall radiographs of endodon-
findings. The greatest fault with the radiograph relates tic treatments, for clinical evaluation, to a group of radi-
to its physical state; it is a record of a shadow, and as ologists and endodontists. They assessed success and
such only two dimensions are shown on a single film. failure by observation of radiodensities. There was more
As with any shadow, these dimensions are easily dis- disagreement than agreement among the examiners.
torted through improper technique, anatomic limita- Radiographs are an essential aid to diagnosis but must
tions, or processing. In addition, the buccal-to-lingual be used with discretion. However, radiographs are the
A B
Figure 9-1 Disclosing canals by radiography. A, Right-angle horizontal projection reveals four files in separate canals superimposed. B,
Horizontal angulation varied 30 degrees mesially reveals all four canals and file short of working length in mesiolingual canal (arrow).
Reproduced with permission from Walton RE.27
A B C
Figure 9-2 Locating canal of the receded pulp. A, Advanced calcification and receded pulp. B, Radiograph reveals angulation of prepara-
tion and canal (arrow) at mesial of cut. C, Canal, seen in radiograph, is discovered with a fine file. (Courtesy of Dr. Steven Koehler.)
only method whereby the dentist can visualize that Traditional Machines
which he cannot see or feel during the process of diag- Two basic types of x-ray machines are commonly used
nosis and treatment. He will discover that, as his radi- in dental offices. One type has a range of kilovoltage
ographic techniques and interpretation improve, so will and two milliamperage settings with which the long
the ease and success of his root canal treatment. The (16-inch) cone is frequently used. The other type offers
techniques outlined in the following sections have only one kilovoltage and milliamperage setting and
proved to be successful and predictable. If followed, they only the short (8-inch) cone. Either type provides ade-
will greatly simplify difficulties in root canal treatment. quate radiographs. However, each has advantages that,
INSTRUMENTATION under different circumstances, will yield a more satis-
factory result. The long-cone system is superior for
Systems diagnostic radiographs, whereas the flexible short-cone
There are two radiographic approaches. The tradition- machine is more appropriate for treatment or work-
al approach is the x-ray exposure of film, which is then ing films. Any x-ray machine must be properly shield-
chemically processed to produce an image. The newer ed and collimated by means of a lead diaphragm and
digital radiography systems rely on an electronic detec- filtered by aluminum disks to ensure proper radiation
tion of an x-ray-generated image that is then electron- safeguards for the patient and professional personnel.
ically processed to produce an image on a computer An additional protective measure is the draping of the
screen, an image that is similar in interpretative quality patient with a lead apron to block scatter radiation.
to the traditional radiograph.1316 Advantages of digi- Long Cone. Because of the clarity of detail and
tal radiography include reduced radiation of the minimum distortion inherent in the long-cone parallel
patient, speed of obtaining the image, enhancement of technique,1821 the long-cone machine is preferred for
the image, computer storage, transmissibility, and a exposing diagnostic, final, and follow-up radiographs.
system that does not require chemical processing.17 Short Cone. Because of the number of working
Disadvantages are cost and ease of use, although radiographs taken in the course of endodontic therapy,
endodontists are not finding these to be a determent to the practitioner treating more than the occasional
their practice, in which speed and the preceding fea- tooth will find that a short-cone machine, with a small,
tures are important. As costs decrease and technology easily manipulated head, saves much time, energy, and
improves, use of the digital system will undoubtedly frustration (Figure 9-3).
increase by all practitioners. Digital radiography is dis- Film. Industrial technological advances have
cussed in full later in the chapter. allowed film exposure time to be reduced to fractions of
fer somewhat from the methods for placement of diag- in mandibular posterior areas where closing relaxes the
nostic, final, and follow-up films. mylohyoid muscle, permitting the film to be positioned
Diagnostic Radiographs. These must be the best farther apically; (3) the handle of the hemostat is a
radiographs possible. To achieve this goal, there are guide to align the cone in the proper vertical and hori-
advantages to parallelism, which permits more accu- zontal angulation (Figure 9-6); (4) there is less risk of
rate visualization of structures as well as repro- distortion of the radiograph caused by too much finger
ducibility. This facilitates comparison of follow-up pressure bending the film; and (5) patients can hold a
radiographs. hemostat handle more securely with less possibility of
There are a number of devices on the market that film displacement. In addition, any movement can be
ensure film placement and parallelism. The Rinn XCP detected by the shift of the handles and corrected
(Dentsply/Rinn Elgin, Ill.) virtually guarantees distortion- before exposure.
free films but cannot be used with the rubber dam in In all instances of film placement, the identifying
place. The Rinn Endoray II endodontic film holder is dimple should be placed at the incisal or occlusal edge
designed specifically to ensure parallelism yet avoid rub- to prevent its obscuring an important apical structure.
ber dam clamps while allowing space for files protruding Cone Positioning. It is a mistake to rely on only
from the tooth (Figure 9-5). Film holders are preferred to one film. There is much to be learned from additional
finger retention of the film. A straight hemostat is an exposures taken from varied horizontal or vertical
excellent film holder. projections.
Working Radiographs. One great difficulty in root Vertical Angulation. Ordinarily, it is preferable to
canal therapy is the clumsy, aggravating method of tak- align the cone so the beam strikes the film at a right
ing treatment radiographs with the rubber dam in angle. This alignment ensures a fairly accurate vertical
place. Some dentists remove the rubber dam frame for image. Elongation of an image, however, may be cor-
access in film placement, and saliva enters to contami- rected by increasing the vertical angle of the central
nate the operating field. It is therefore imperative that a
film-placement technique be used so that the rubber
dam frame need not be removed. Use of a radiolucent
N- (Nygaardstby) frame (Coltene/Whaledent/
Hygenic; Mahwah, N.J.), le Cadre Articul-type frame
(Jored, Ormoy, France, or Trophy, USA) (see Figures 9-
57 and 9-58), or the Star VisiFrame (Dentaleze/ Star,
USA) will ensure that apices are not obscured.
With the rubber dam in place, a hemostat-held film
has significant advantages over the finger-retained film:
(1) the film placement is easier when the opening is
restricted by the rubber dam and frame; (2) the patient
may close with the film in place, a particular advantage
ray. Conversely, foreshortening is corrected by decreas- The contrast gained by varying the horizontal pro-
ing the vertical angle of the central ray. To remember jection can best be seen in a clinical case with four
this, one should think of the sun: it casts a shortened canals. Figure 9-10, A, taken at a right angle, clearly
shadow at noon when it is at its zenith, or increased shows the four instruments superimposed on one
vertical angle. another. Figure 9-10, B, on the other hand, taken from
Frequently, an impinging palatal vault prevents par- a 30-degree variance in horizontal projection, empha-
allel alignment of the film and the teeth. However, if the sizes the third dimension: the separation of the instru-
film angle is no greater than 20 degrees in relation to ments in the canals. By applying Ingles rule (MBD:
the long axis of the teeth, and the beam is directed at a shoot from the mesial), one also determines that the
right angle to the film, no distortion occurs, although buccal canals are toward the distal.
there is a less effective orientation of structures.26 The Another point should be made at this time con-
resulting radiograph is still adequate. cerning a frequent mistake in reading periradicular
Horizontal Angulation. Walton introduced an radiographs. It can best be illustrated by a cross-sec-
important refinement in dental radiography that has tional drawing of molar root structure. Roots con-
materially improved the endodontic interpretive taining two canals are often hourglass-shaped, as
film.27 He demonstrated a simple technique whereby Figure 9-11, A, indicates. When an x-ray beam passes
the third dimension may be readily visualized. directly through this structure, the buccal and lingual
Specifically, the anatomy of superimposed structures, portions of the root are in the same path (arrows).
the roots and pulp canals, may be better defined. Because a double thickness of tooth structure is pen-
The basic technique is to vary the horizontal angu- etrated by the x-rays, it is seen in the film as a
lation of the central ray of the x-ray beam. By this radiopaque root outline in close contact with the
method, overlying canals may be separated, and by lamina dura. This is readily apparent on the radi-
applying Clarks rule,28 the separate canals may then be ograph (Figure 9-11, B).
identified. Clarks rule states that the most distant By aiming the cone 20 degrees from the mesial, howev-
object from the cone (lingual) moves toward the direc- er, the central beam passes through the hourglass-shaped
tion of the cone. Stated in another way, using a help- root at an angle (Figure 9-12, A). In this case, the two thick-
ful mnemonic, Clarks rule has been referred to as the nesses of the root are projected separately onto the film.
SLOB rule (Same Lingual, Opposite Buccal): the object Since less tooth structure is penetrated by the x-ray, the
that moves in the Same direction as the cone is located image on the film is less dense. A radiolucent line is clearly
toward the Lingual. The object that moves in the seen in Figure 9-12, B (open arrow). This radiolucent line
Opposite direction from the cone is located toward the can be erroneously read as a root canal. One should take
Buccal. The SLOB rule, simply stated, is The lingual care to follow up the length of the line. Instead of entering
object will always follow the tube head. Goerig and the pulp chamber, it can be traced to emerge at the gingival
Neaverth cleverly applied the SLOB rule to determine, surface of the root. This simple interpretive error can easily
from a single film, from which direction a radiograph lead to gross mistakes in endodontic cavity preparation.
was taken: mesial, straight on, or distal. Knowing the Mandibular Premolars. The importance of varying
direction, one is then able to determine lingual from the horizontal angulation when radiographing
buccal29 (Figure 9-7). Stated more simply, Ingles rule is mandibular premolars is demonstrated in Figure 9-13,
MBD: Always shoot from the Mesial and the Buccal A, wherein the central ray is directed at a right angle to
root will be to the Distal. the film. What appears to be a single straight canal is
Horizontal Angulation Variations. Mandibular discernible in each premolar (Figure 9-13, B). There is
Molars. As previously emphasized, the film must be an indication, however, in the image of the first premo-
positioned parallel to the lower arch. The standard lar that the canal might bifurcate at the point of the
horizontal x-ray projection then is at a right angle to abrupt change in density (arrow).
the film (perpendicular), as shown in Figure 9-8. The Directing the central ray 20 degrees from the mesial in
two mesial canals are superimposed one upon the the first premolar (Figure 9-14, A) causes the bifurcation
other and appear as a single line. to separate into two canals (Figure 9-14, B). The tapering
Through the Walton projection, however, the canals outline of the tooth, seen in both projections, would
can be made to open up. This is done by directing the indicate, on the other hand, that the two canals
central beam 20 to 30 degrees from the mesial (Figure undoubtedly rejoin to form a common canal at the apex.
9-9, A). In Figure 9-9, B (black arrows), the two canals In both the right-angle and 20-degree variance projec-
in each root can now be readily discerned. tions, the second premolar appears as a single canal.
A B
C D
Figure 9-7 Applying the SLOB rule to determine the direction from which the film was taken. Anyone knowing the direction can tell lin-
gual from buccal. Clues that the film is taken from the mesial: A and B, The mesial-buccal (MB) root lies over the palatal (P) root, that is,
the lingual (palatal) root has moved mesially; the lingual arm of the rubber dam clamp (arrow) has moved mesially. The canine is visible.
Once it has been determined that the radiograph was taken from the mesial, the lingual root (toward the mesial) of the premolar is defined.
C and D, Radiograph of the same teeth taken from the distal. Clues are reversed. There is no canine visible in the film, and the lingual pre-
molar canal is now toward the distal. Reproduced with permission from Goerig AC. In: Besner E, et al., editors. Practical endodontics. St.
Louis (MO): Mosby; 1993. p. 54.
Maxillary Molars. Maxillary molars are consistent- The standard right-angle projection for a maxillary
ly the most difficult to radiograph because of (1) their first molar that is illustrated in Figure 9-15, A, pro-
more complicated root and pulp anatomy, (2) the fre- duces the image seen in Figure 9-15, B, wherein the
quent superimposition of portions of the roots on each zygomatic process is superimposed on the apex of the
other, (3) the superimposition of bony structures palatal root (arrow) and the distobuccal root appears
(sinus floor, zygomatic process) on root structures, and to overlie the palatal root. The sinus floor is also
(4) the shape and depth of the palate, which can be a superimposed on the apices of both the first and sec-
major impediment. ond molars.
As is true of the mandible, the complex root anato- When the horizontal angulation is varied by 20
my and superimpositions may be dealt with by vary- degrees to the mesial (Figure 9-16, A), the zygomatic
ing the horizontal angulations. Film placement must process is moved far to the distal of the first molar and
again be parallel to the posterior maxillary arch, not to the distobuccal root is cleared of the palatal root
the palate. (Figure 9-16, B, arrows).
Figure 9-8 Mandibular molars. A, Central ray directed at right angle to film positioned parallel to arch. B, Limited information is gleaned
from radiograph because of superimposition of structures and canals. Reproduced with permission from Walton RE. 27
Figure 9-9 Mandibular molars. A, Central ray directed at 20 degrees mesially to film positioned parallel to arch. B, Two canals are now visible in
both roots of the first molar (black arrows). Open arrow indicates confusing root outlines. Reproduced with permission from Walton RE.27
Figure 9-10 Mandibular molars. A, Right-angle horizontal projection superimposes four files, one on the other. B, Horizontal variance of
30 degrees separates four canals. SLOB rule proves lingual canals are to the mesial. Reproduced with permission from Walton RE. 27
Figure 9-11 A, X-ray beam passing directly through two thicknesses of root structure presents intensified image on film. B, Note
radiopaque root outline inside lamina dura. B reproduced with permission from Walton RE. 27
The opposite projection also can be used to isolate ography, particularly for the first premolar, which
the mesiobuccal root of the first molar, that is, the cen- generally has two canals, but sometimes three. The
tral ray may be projected from 20 degrees distal to the clinical efficacy of the Walton technique is well illus-
right angle (Figure 9-17, A). Although this projection trated in Figure 9-18. The right-angle horizontal pro-
distorts the shape of the mesiobuccal root, it also iso- jection produces the single canal image seen in Figure
lates it (Figure 9-17, B), so that the canal is readily dis- 9-18, A. By varying the angulation by 20 degrees,
cernible (arrow). Also note that the zygomatic process however, the two canals are separated (Figure 9-18,
is moved completely away from any root structure, B), giving an unobstructed view of the quality of the
including the second molar. fillings in both canals.
The same technique illustrated here for the maxil- Mandibular Anterior Teeth. Aberrations in canal
lary first molar can be applied to the second or third anatomy in the mandibular anterior teeth are infa-
molars by directing the central beam at a horizontal mous. Variance of the horizontal x-ray projections in
variance through those teeth. this region will bring out the differences. Figure 9-19,
Maxillary Premolars. Variance in the horizontal A, illustrates the standard x-ray projection bisecting the
projection has great value in maxillary premolar radi- film held parallel to the arch. The incisor teeth appear
Figure 9-12 A, X-ray beam aimed 20 degrees mesially passes through single thicknesses of hourglass root, leaving less dense impression on
film. B, Radiolucent line is apparent (open arrow) and may be confused with root canal. Note that it emerges at gingival, not into pulp cham-
ber. Black arrows indicate regular canals. B reproduced with permission from Walton RE. 27
Figure 9-13 Mandibular premolars. A, Central ray directed at right angle to film positioned parallel to arch. B, Radiograph reveals one canal
in each premolar, although abrupt change in density (arrow) may indicate bifurcation. Reproduced with permission from Walton RE. 27
to have single canals. But a broad single canal is seen in Clausen have shown, for example, how difficult it is to
the distorted canine image (Figure 9-19, B). determine when foramina exit to the labial or lingual.30
By varying the film placement and projecting directly Their radiographs of extracted teeth matched with
through the canine, as seen in Figure 9-20, A (which is photographs of instrument perforation short of the
about 30 degrees variance for the incisors), separate canals apex are a warning to all (Figure 9-21).
appear in the incisors (Figure 9-20, B, arrow) and are then Processing. Another deterrent to full endodontic
seen to coalesce at the apex. This would be expected, how- utilization of radiography has been the length of time
ever, when one views the tapered incisor roots seen in required in most offices to process films. Old, weakened
both horizontal projections, roots far too narrow to sup- solutions greatly increase the time required for process-
port two separate canals and foramina. Once again, the ing. Moreover, adherence to the manufacturers recom-
abrupt change in canal radiodensity in the premolars mended temperature and time (68F for 5 to 7 minutes)
(arrow) should make one suspicious of canal bifurcation, for developing and clearing has retarded on-the-spot
a fact that has already been confirmed in Figure 9-14, B. processing and viewing in most busy practices.
Maxillary Anterior Teeth. Although canal or root Ingle, Beveridge, and Olson demonstrated, in a
aberrations appear less frequently in the maxillary well-controlled blind study, the effects of varied pro-
anterior teeth, root curvature in the maxillary lateral cessing temperatures. A processing temperature of 92F
incisors is a particularly vexing problem. Grady and yielded, in less than 1 minute, the most acceptable
B
A
Figure 9-14 Mandibular premolars. A, Central ray directed at 20 degrees mesially to film, parallel to arch. B, In first premolar, two canals
that are clearly visible (arrow) probably reunite, as indicated by sharply tapered root. Reproduced with permission from Walton RE. 27
Figure 9-15 Maxillary molars. A, Central ray is directed through maxillary molar at right angle to inferior border of film. Arrow and dot-
ted line passing through malar process indicate it will superimpose over first molar. B, Superimposition of first molar roots, sinus floor, and
malar process (white arrow) confuse the diagnosis. Reproduced with permission from Walton RE. 27
Figure 9-16 Maxillary molars. A, Central ray directed at 20 degrees mesially skirts malar process, projecting it distally. B, Distobuccal root
is cleared of palatal root and malar process is projected far to distal (white arrow). Between right-angle and 20 degrees projection, all three
roots are clearly seen. Reproduced with permission from Walton RE. 27
Figure 9-17 Maxillary molars. A, Central beam projected 20 degrees from the distal. B, Mesiobuccal root of the first molar is isolated (black
arrow) and second and third molars are cleared of malar process, which is projected forward (white arrow). Sinus floor may be lowered or
raised by changing vertical angulation. Reproduced with permission from Walton RE. 27
Figure 9-18 Maxillary premolars. A, Horizontal right-angle projection produces illusion that maxillary first premolar has only one canal.
B, Varying horizontal projection by 20 degrees mesially separates two canals. Lingual canal is toward mesial. Reproduced with permission
from Walton RE. 27
radiographs.31 A group of 37 physicians and dentists ing time. Finally, all films need to be final washed for at
selected as best the films developed at 92F from a least 30 minutes.
coded selection of films processed at 4F intervals in the In a practice limited to endodontics only, small
range of 68 to 100F. At 92F, using Kodak developer quart-size tanks are adequate and economical.
and fixer mixed to company specifications, develop- Frequent change of solutions is recommended.
ment required only 30 seconds and fixation required Rapid Processing. Concentrated rapid-processing
25 to 35 seconds, with no loss of quality. chemicals, such as Kodaks Rapid Access solution, have
By comparison, the 70F temperature, recommend- become very popular in endodontic practice.
ed at that time by the manufacturer, required 5 minutes Although they are more expensive ounce for ounce,
developing time and 10 minutes fixing time for they save measurable time, requiring only 15 seconds
Ultraspeed film. Ektaspeed is slightly better: 72 to 80F developing and 15 seconds clearing time in the fixer at
for 212 to 4 minutes developing and 2 to 4 minutes fix- room temperature.
Figure 9-19 Mandibular anterior teeth. A, Film placement for bisecting-angle technique. Horizontal central beam projection at right angle
to film. B, Single canals seen in central incisors with only suggestion of two canals in lateral incisor. In distorted image of canine, note broad
labiolingual canal dimension (arrow). Reproduced with permission from Walton RE. 27
Figure 9-20 Mandibular anterior teeth. A, Film is positioned for canine radiograph using bisecting-angle technique. Horizontally, central
beam is projected at right angle to film. B, Canine image is single straight canal, but incisor image reveals bifurcated canals that reunite in
narrow tapered root (arrows). Note bonus image of bifurcated canals, first premolar. Reproduced with permission from Walton RE. 27
A Tel Aviv/UCLA study tested four rapid-developing Dental; Syosset, N.Y.), IFP (M & D International), and
solutions, processing both Ultraspeed and Ektaspeed Instaneg (Neo-Flo, Inc., USA), would deteriorate over
films. Film fog became a problem as the solutions deteri- 60 days. They also found that precise developing time and
orated with time. Kodak Rapid Access had to be changed 3 to 5 seconds rinse time between developing and fixing
every day, whereas the other solutions, Colitts (Buffalo are absolutely essential.32
3 minutes, including the draping. With DDR, however, the pixels have been saturated, and no recovery can be
there is no dead time during the radiographic event made other than re-exposing the sensor.
and no need to mentally re-enter the case. From a patient education perspective, another com-
Retakes. Ease of retakes is often overlooked when puter enhancement that is quite useful is the Pseudo-
discussing time savings. Ease of retakes is the real time 3D feature shown in the Trophy software (Figure 9-
saver. With film, a retake requires another 6 minutes or 28). The radiograph is converted to a contour map
more, whereas with digital, a retake takes an instant. An while maintaining the relative gray levels. The radiolu-
even greater benefit is that the x-ray head, patient, and cency at the periapex of the tooth is dark, relative to the
sensor are all still in place. This simplifies interpreta- surrounding structures, and thus appears as a hole in
tion and adjustment to different angles. There is no the bone in the Pseudo-3D view. This allows the clini-
need to remember the case or wonder at what angle cian to communicate, in a more understandable man-
the last radiograph was taken. ner, the loss of periapical bone.
Dose Reduction. Lower x-ray dosage is another
quantifiable benefit of all digital radiography systems. Digital Radiographic Technique for Endodontics
Almost all of the digital systems are capable of reduc- The assistant enters the patients demographics into the
ing exposure to 50% of conventional E-speed film. computer and selects the exam type from the menu
Exposure can be further decreased to less than 20% if that appears on the screen. The sensor is then sheathed
image quality is slightly compromised. This is accom- in a latex finger cot (for sanitary reasons) (Figure 9-
plished by underexposing the sensor and then using 29) and correctly positioned intraorally. The x-ray head
the computer-processing functions to visually improve is then positioned, the computer software is activated,
the image quality. and x-ray exposure is made. The computer has cap-
With the growing concern of patients regarding tured and stored the image as it appears on the moni-
radiation exposure, digital systems help defuse their tor screen (Figure 9-30). If adjustments are needed, the
concerns about radiography. sensor and/or the x-ray beam (head) may be reposi-
Computer Processing. Although the software pro- tioned while the sensor is still in place. Again, the cor-
grams provided with the different digital radiography rected image appears on the screen to guide the dentist
systems have a dazzling array of image-processing algo- and/or instruct the patient. All of the images will be
rithms, only a few are of primary importance in stored and may later be recalled to complete the
endodontics. The most important image-processing patients record. The before and after images can then
tool is the brightness/contrast tool. Images that are be transported by hard copy or electronic mail to the
washed out or underexposed can often be computer referring dentist.
processed to increase their contrast and decrease the Tooth Length Measurement. The ability to accu-
brightness (Figure 9-27). However, as useful as this tool rately measure preoperative working length is another
is, it cannot correct a badly overexposed image because useful tool. Since the pixel sizes making up the digital
A B
Figure 9-27 Computer processing to enhance image. Left, Slightly underexposed, unprocessed image. Right, Computer-processed image
highlights resorptive defect over the distal root. (Courtesy of John A. Kahdemi.)
To use the DSR technique, the two digital images to RADIOGRAPHIC INTERPRETATION
be compared are brought into the computer software. Since properly positioned, exposed, and processed
Since they are digital images, they are stored in a radiographic or digital images (Figure 9-33) are of
numeric format in the computer memory and can be value only if they are properly interpreted, every advan-
compared mathematically. Typically, the background tage must be taken to obtain the most information
images that have not changedcrowns, fillings, and so from the image. For the student and seasoned practi-
forthare subtracted, which in turn highlights areas tioner alike, a good magnifying glass has often brought
that have changedlesion size and/or density, for to light an extra root, root canal, or hard-to-find apex.
instance.43 A superlative method for examining radiographs is
the Brynolf magnifier-viewer.45 This device enhances
Tomography
the viewing of individual films in two ways: the image
Another exciting development is the generation of den- is magnified several times, and all peripheral light is
tal tomographic images44 (E Hebranson and P Brown, effectively blocked out. Masking the light source
personal communication, 1999). Tomography is a radi- around a radiograph greatly increases the ability of the
ographic technique that essentially slices the teeth viewer to distinguish grades of density.46 A film that
into thin sections. Computers then reassemble the sec- has been slightly overexposed, if magnified and
tions to generate a three-dimensional image. When inspected over a strong light, yields a remarkable
these techniques are refined, pulp spaces and roots will amount of unsuspected information. In a re-treated
be visualized in the third dimension. Buccolingual cur- case, endodontic success had been denied for 9 years
vatures will be evident, as well as the shape of the canal until inspection under magnification of the original
space and the location of the apical foramen (Figure radiograph disclosed a previously overlooked third
9-32). An additional advantage would be the elimina- root on a maxillary first premolar.
tion of specialized angled radiography; all angled views Many departures from classic radiographic proce-
will be simultaneously captured in one exposure. dures have been strongly advocated for endodontic
A B
Figure 9-32 Tomographic images of a maxillary molar reconstructed by computer. Tomography essentially slices the image into thin sec-
tions and then reassembles them into a three-dimensional image. A, Buccal view. B, Mesial view. (Courtesy of John A. Khademi.)
A B
Figure 9-33 A, Poorly processed radiograph lacks definition for proper diagnosis. B, Properly processed radiograph of same case yields
diagnostic details lacking in A. (Courtesy of A. C. Goerig and E. J. Neaverth.)
therapy. Any variation that makes the exposure and Abulkasim, in AD 1012, used a mirror to reflect light
processing of radiographs easier, faster, and better, and through the hollow tube. Aranzi, in 1585, used reflect-
the interpretation more thorough, increases the value ed solar rays to peer into nasal cavities. Bonzzani
of these eyes beneath the surface. It is when we do not (1804) used a candle as a light source, and Segalas in
see what we are doing that failures increase. 1826 added a cannula for ease of insertion.
Desormeaux (1835) is considered the father of
VISUAL ENHANCEMENT endoscopy, using kerosene lamplight reflected through
Endoscopy a mirror system. He used this system as a cystoscope
Light and magnification are key factors in endodontics and a urethroscope. Panteleone (1869) refined the
because what cannot be seen cannot be properly treat- Desormaux scope for looking into the uterus. In 1877,
ed. The Endoscope (Karl Storz, Germany/USA) and the Nitze added an optical lens system to the tube. Dittel
Orascope (Sitca, Inc., USA) provide both light and (1887) added a small incandescent bulb at the end of a
magnification for better access and location of canal cystoscope as a light source. (Thomas Edison invented
orifices, fractures, failing silver points, separated instru- the incandescent lamp in 1880.) By the end of the nine-
ments, and posts. They are also extremely useful in teenth century, there existed cystoscopy, proctoscopy,
endodontic surgery, including apicoectomy, retrofill- laryngoscopy, and esophagoscopy. In 1901, Ott was the
ings of the root end, location and repair of perfora- first to make a small incision into the abdomen and use
tions, and internal and external resorptive defects. a mirror head to reflect light. Also in 1901, Kelling
Endoscopy is the inspection of body cavities and injected air through a separate needle during a cysto-
organs using an endoscope. This device consists of a scopic procedure in a dog as the first closed endoscop-
tube and an optical system with a high-intensity light. ic procedure. Takagi (Tokyo 1918) was the first to
The image captured by the endoscopic camera is pro- examine the knee joint. In 1952, Hopkins used quartz
jected onto a video monitor for viewing (Figure 9-34). rods in the tube of the scope to project light into the
In endodontics, one can visualize access openings, operating field, and in 1968 fiber optics were added,
canal orifices (Figure 9-35), the canal interior, frac- and the system that is used today came into being.47
tures, resorptive defects, and surgical sites, all highly The first use of the endoscope in endodontics was to
magnified. observe fractures in teeth.48 Held et al.49 and Shulman
Endoscopy dates back to the time of Hippocrates II and Leung50 in 1996 reported the use of the endoscope
(460375 BC) when physicians of the time used tubes for both conventional and surgical endodontics.
inserted into body openings to view interior structures. Bahcall et al. recently described using the endoscope
Endoscopes for endodontics can be obtained in 4- ers 800 lines per second. For comparison, a standard
and 8-inch lengths. The tube of the working end of the television delivers 265 lines per second. For endodontic
endoscope contains quartz rods, some of which bring procedures, at this time, a one-chip camera will pro-
light into the field of operation and some of which vide sufficient definition and clarity.
return the image to the camera that projects the image The camera control unit controls color density and
onto the video monitor. The working end of the scope shutter control. Automatic gain control ensures clarity
can be obtained in a wide variety of angulations: 0, 30, of the picture. The signal degenerates with a longer
45, 90, and 135 degrees. The most useful endoscope for cable and the devices (video recorder and printer)
endodontics is the one having a 30-degree angle. through which the signal has to travel before it reaches
The endoscope comes in a variety of widths, from the monitor where it can be viewed. Any size monitor
0.7 to 10 mm. The most useful width for endodontic can be used; however, as the screen increases in size, the
surgical procedures is 4 mm, and for conventional sharpness of the image decreases.
endodontic treatment, a 0.7 to 4 mm scope is best. A video recorder can be used to capture an
The source of light is delivered to the scope by fiber- endodontic procedure. The best quality image for ana-
optic cables. Hundreds of glass fibers are bundled log video is the Hi 8 system. The highest quality image,
together to carry light to the quartz rods inside the however, is recorded by using a digital video recorder,
scope. Light can come from either a halogen or a xenon wherein the images can be edited and copied multiple
source. A halogen light will provide from 150 to 300 times, with no loss of resolution, as will occur with an
watts of illumination with a slightly yellow hue. A analog system.50
xenon light source at 300 watts will provide light with Stability of the scope itself is important. A variety of
a white hue that will have greater consistency and sheaths inserted over the tube of the scope are used to
brightness. The xenon light is also more penetrating provide rigidity, support, and stability. They also pro-
than is the halogen. tect the tip from potential damage from instruments.
The camera coupler/lens attaches to the end of the Shulman has described a stabilization technique for
scope. The coupler can be equipped with a zoom con- endodontic surgical procedures. He suggests placement
trol that allows a closer view in the form of a zoomed of the end of the rigid sheath on the surface of the
picture that will usually fill the entire monitor screen. bone, adjacent to the surgical site, thus producing a sta-
Cameras are produced in one- and three-chip mod- ble video image.50
els. A one-chip camera will deliver 450 lines per second The sheaths come with a variety of working ends.
of image to a video monitor. A three-chip camera deliv- Canal orifices, calcified canals, perforations, and
resorptive defects can be viewed using a forked-ended
sheath that can rest on access openings, a marginal
ridge, or the buccal or lingual surface of the tooth being
treated or an adjacent tooth (Figure 9-37, A). Sheaths
with retractors that have serrated ends that are a simi-
lar shape to that of a handheld retractor can be
anchored on bone to provide support and flap and
cheek retraction during surgery (Figure 9-37 B). A
sheath shaped like a tongue retractor is used to move
the patients tongue aside while viewing the lingual
aspect of a tooth. The scope can be anchored in posi-
tion by the sheath and the lens/camera coupler can
then be rotated 360 degrees to completely view all
aspects being treated.
During procedures involving rotary instruments, the
tip of the endoscope can become covered with debris
Figure 9-36 The Endoscope System. The Scope, surveying tooth, and the video picture can become blurred. Saline in a
contains quartz rods that convey the image. They, in turn, are sur- syringe or sterile water from a triplex or Stropko
rounded by a fiber-optic light source. The Scope is attached to the syringe (see chapter 12, Endodontic Surgery) can be
camera by a camera coupler, which in turn connects to the com-
puter and printer as well as to the monitor. Images appear on the
used to rinse away the debris and clear the viewing field
monitor and are stored in the computer for later printing if desired. on the monitor. A cotton swab saturated with saline
(Courtesy of F. H. Kahn and B. B. Shulman.) solution can also be used to accomplish debris removal.
1.8 mm probe has 30,000 fibers and the 0.7 has 10,000.
A ring of light transmitting fibers surrounds the visual
fibers (Figure 9-39). Both probes have a large depth of
field and do not need to be refocused after the initial
focus. The 1.8 mm probe is used to visualize conven-
tional and surgical sites.51 The 0.7 mm probe is used
for that and for intracanal visualization as well (Figure
9-40). Canal cleanliness, location of accessory canals,
perforations, broken instruments, and resorptive
defects are easily examined.52,53 The 0.7 mm probe
must be used in a dry canal. It will not penetrate blood,
exudate, or irrigant. The coronal two-thirds of the
canal should be flared to at least a size 70 instrument.
Jedmed is planning to release an endoscopic system
called Endodontic Endoscopic Systems (E.E.S.).
Figure 9-37 Protective metal sheaths that slip over the scope
provide rigidity and allow the scope to be held in a stable position. Future Possibilities
A, Fork-ended sheath fashioned to rest on access openings and/or
marginal ridges. B, Sheaths with serrated ends are used as retrac- Many advances being made in medical endoscopy can
tors anchored in bone. Stability provides constant focus. (Courtesy easily be adapted to endodontic endoscopic procedures.
of B. B. Shulman.) Software can piece two-dimensional images together to
create a virtual three-dimensional fly-through. Virtual
After use, the sheaths should be placed in an ultra- reality technique training will enhance and speed the
sonic cleaner to remove debris and sterilized in an auto- learning curve for difficult endodontic procedures.
clave with ethylene oxide or glutaraldehyde. The scope Video and audio conferencing using a webcam, which is
cannot be placed in an ultrasonic cleaner but can be an endoscope to project video images, digital radi-
easily cleaned by soaking in an enzymatic cleaner or ographs, and patient files, can be sent over the Internet
washed gently with soap and distilled water and then so that dentists anywhere in the world are able to confer
sterilized in glutaraldehyde for 12 hours. Autoclavable and obtain the best diagnosis and treatment planning
scopes are also available. The lens head/camera coupler for their patients. Future possibilities are unlimited.
can be cleaned with a mild soap and distilled water and
sterilized by soaking in glutaraldehyde. It is best pro- SPECIALIZED ENDODONTIC INSTRUMENTS
tected with a disposable plastic tubewrap during use AND EQUIPMENT
to keep it sterile and free of debris. The lack of proper equipment is a reason often given
The Orascope (Sitca, Inc., USA) is an evolutionary by dentists who do not practice root canal therapy, and
extension of dental endoscopy: Orascopy. Currently, it well might be. Not only are special instruments
there are two diameter sizes of flexible fiber-optic imperative for endodontic treatment, but a special
probes: the 1.8 mm and the 0.7 mm (Figure 9-38) The arrangement of these instruments is necessary.
Figure 9-42 Handy Endoring worn by dentist working alone. Figure 9-43 Sterile burs are placed in contra-angle handpiece
Premeasured instruments are arranged in order in sterile, dispos- with sterile pliers. Bur is dropped into place by holding shaft of
able plastic sponge. (Courtesy of Jordco, Inc.) bur with pliers and spinning foot control.
gerous when an extra long bur is being used to ampu- tions have been developed for the clinician who treats
tate an entire root. all types of endodontic problems in a general practice
of dentistry. The case and its contents are sterilized
Endodontic Instrument Case according to the directions given under Asepsis in
The collection of tiny endodontic instruments must be Endodontic Practice, chapter 3. The surgical arma-
kept in an organized arrangement yet lend itself readi- mentarium is dealt with in Endodontic Surgery,
ly to sterilization. The metal endodontic instrument chapter 12. Table 9-1 lists the contents of the endodon-
case meets these requirements. Storage cases have long tic instrument case.
been available but never as refined as the modern cases
(Figure 9-44). All of the reamers, files, broaches, burs, PAIN CONTROL IN ENDODONTICS
and filling equipment, as well as paper points and cot- In no other area of dentistry is the management of pain
ton pellets, are stored and sterilized in the case. The of greater importance than in endodontics. All too
dentist or assistant removes these with sterile pliers often the patient in need of endodontic therapy has
only as needed. endured a prolonged period of ever-increasing discom-
The instrument case may be placed beside the den- fort before seeking dental care. The reasons for this dis-
tist on a Mayo stand, or the assistant may obtain comfort are manifold; however, there is one simple
material from the case kept on the cabinet top. explanation in the overwhelming majority of these
Supplies are transferred from the case to the open patients: They are scared! They are afraid of dentistry,
towel kit, which is the working surface. The case needs which might be the reason for their dental problems in
to be resterilized only when one of the instrument the first place; they are frightened of root canal work
sizes is depleted. New instruments should replace because of the common perception that it hurts; and
sizes 10 through 25, which should be used only once. they are often terrified at the thought of receiving local
The larger instruments may be thoroughly cleaned anesthetics, or shots, in patient parlance.
and reused when the case is replenished before steril- It is possible to achieve clinically effective pulpal
ization. A thorough discussion of endodontic instru- anesthesia on all teeth, infected or not, in any area of
ments is found in chapter 10. the oral cavity, with a very high degree of success and
A selection of instruments is available from the var- without inflicting any additional pain on the patient in
ious distributors of endodontic supplies. These selec- the process.
E
Figure 9-44 Five examples of instrument kits. A, ENDO-BLOC. B, University Case. C, ENDEX Endodontic System. D, Guldener
SPLIT-KIT. E, TEXAS Case. (A, Courtesy of Endobloc, Inc., Cincinnati, OH; B, Courtesy of Union Broach, New York; C, Courtesy of
Whaledent International, New York; D, Courtesy of Dentsply/Maillefer; E, Courtesy of University of Texas, San Antonio, TX.)
In the following section, common (and some Table 9-1 Contents of the Endodontic Instrument
uncommon) local anesthesia techniques that are used Case
to provide effective pain control during dental treat-
Style B Hand Instruments .02.04 Tapers*
ment are presented.
1 6 file, B, #08 1 6 file, B, #50
Although it is possible (and probable) that the
1 6 file, B, #10 1 6 file, B, #55
administration of local anesthesia will be both atrau-
1 6 file, B, #15 1 6 file, B, #60
matic to the patient and clinically effective, many
1 6 file, B, #20 1 6 file, B, #70
endodontic patients (and, unfortunately, some profes-
1 6 file, B, #25 1 6 file, B, #80
sional colleagues) do not share that feeling. Given that
1 6 file, B, #30 1 6 file, B, #90
a significant percentage of these patients are dental
1 6 file, B, #35 1 6 file, B, #100
phobics, and that one of the greatest fears they harbor
1 6 file, B, #40 1 6 file, B, #120
is the fear of pain, it is not unusual for these patients to
1 6 file, B, #45 1 6 file, B, #140
experience pain at any and all times during treat-
1 6 file, B, Golden Mediums, # 1237
ment, warranted or not. There are the patients who
1 12 files Hedstrom, assorted # 25110
jump when air is blown into the mouth; who exhibit an
overactive gag reflex when anything is placed on the Burs
tongue or palate; who are moving targets during 1 3 bur, carbide #701U, RA
administration of the local anesthetic; who complain of 1 6 bur, #2 (3 surgical, 3 standard, RA)
pain constantly during treatment, even when the 1 6 bur, #4 (3 surgical, 3 standard, RA)
treatment being performed is truly incapable of pro- 1 6 bur, #6 (3 surgical, 3 standard, RA)
voking a true pain response (eg, cutting enamel or Broaches
removal of an existing restoration). 1 6 barbed broaches, fine
The pain reaction threshold (PRT), defined as that 1 6 barbed broaches, medium
point at which a person will interpret a stimulus as 1 6 barbed broaches, coarse
being painful, can be altered significantly in a given 1 6 barbed broaches, extra coarse
patient. These alterations can be to the patients benefit
Obturation Instruments
(elevation of the PRT) or disadvantage (lowering of the
2 only cement spatula, #3
PRT). Given that there is significant variation in indi-
2 only glass mixing slab, opal
vidual response to stimulation (as described by the
Paper points: fine, medium, and coarse
normal distribution curve), approximately 70% of a
Cotton pellets: large and small
given population will respond appropriately to a given
stimulus (eg, may say ow when receiving a mild Special Towel Kits
painful stimulus). An additional 15% will under-react 6 only: double-ended, hand style, M-spreader/pluggers
to the same stimulus. Their interpretation of this mild- 8 only: Schilder pluggers,
ly painful stimulus will be that it did not hurt at all. 812 Cold sterilized or presterilized gutta-percha points
This 15% of the population is called hypo-respon- and cones, assorted sizes (Dentsply/Tulsa, USA)
ders. Thus, approximately 85% of a normal popula-
*The same selection can be made for engine-driven nickel-titani-
tion will respond as expected to mildly painful stimuli. um (NITI) instruments, sizes 1580. Both stainless and NITI
It is the remaining 15% of patients who are the hyper- files have color-coded handles.
responders. Hyper-responding persons will interpret
as painful what are usually nonpainful stimuli. And
then there are the truly remarkable persons the
Indian fakir who is capable of walking across hot coals To increase the likelihood of pain-free endodontic
or lying on a bed of nails without experiencing any treatment and to ensure the patient a comfortable
pain, or the stoic dental patient who withstands excru- experience, every dentist should make an effort to
ciating pain during every aspect of treatment. modify any of the factors acting to lower the PRT.
With endodontic therapy, the number of patients Chapter 18 covers a subject of great importance to
who will hyper-respond to stimulation is significantly the endodontist (analgesics), but also of importance to
increased. Factors that lower the pain reaction include the endodontic patient is the matter of sedation. Fear
(1) the presence of pain at the start of treatment, (2) and pain are a potent combination, capable of provok-
fatigue, and (3) fear and anxiety. To varying degrees, all ing some of the most catastrophic situations in the den-
may be present in endodontic patients. tal office, such as cardiac arrest. In surveying the inci-
dence of medical emergencies in the dental environ- needle-phobic dental patients. Continued administra-
ment, Malamed found that 54.9% occurred during the tion of N2OO2 during the endodontic procedure is
administration of the local anesthetic and an additional entirely appropriate if the patient is at all apprehensive.
22.0% occurring during dental treatment.54 When the In addition to relieving patients anxieties, N2O acts to
medical emergency arose during treatment, 65.8% of elevate the PRT, providing a beneficial effect through-
the occasions were either the extirpation of the pulp out the endodontic procedure. N2OO2 is the safest of
(38.9%) or extraction of a tooth (26.9%). The acute all conscious sedation techniques and, when properly
precipitating cause of the medical emergency was inad- used, is also one of the most effective.
equate pain control. Although the patient had received When inhalation sedation is contraindicated (eg,
the local anesthetic and had experienced subjective patient is a mouth breather, patient has a cold or
symptoms of anesthesia (eg, numb lip and tongue), as upper respiratory infection, or sedation has proved inef-
the extraction proceeded, or as the preparation came fective in the past in eliminating the patients fears),
closer to the pulpal floor, sudden, unexpected pain other techniques of conscious sedation should be con-
occurred. The sudden elevation in blood catecholamine sidered. These include the administration of central
(epinephrine and norepinephrine) levels provoked sig- nervous system-depressant drugs (eg, benzodiazepines)
nificant elevations in both the blood pressure and heart orally, intramuscularly, intravenously, or intranasally.
rate and an exacerbation of the patients underlying The safest and most effective, when used properly, is
medical problems. This resulted in seizures, acute intravenous conscious sedation. With the availability of
episodes of angina pectoris or asthma, cerebrovascular two benzodiazepines, diazepam (Valium) and midazo-
accident (stroke), syncope (fainting), hyperventila- lam (Versed), administered via titration, it is possible to
tion, and psychiatric convergence reactions. eliminate the dental fears of virtually all patients.
Management problems occurring during local anes- Additionally, these drugs provide varying degrees of
thetic administration can be almost entirely prevented
if consideration is given by the doctor to the patients
feelings about receiving shots. Most persons do not Table 9-2 Atraumatic Local Anesthesia Technique
relish the thought of receiving intraoral local anesthet-
1. Use a sterilized, sharp needle.
ic injections, demonstrated by the high incidence of
2. Check the flow of local anesthetic solution before
adverse reactions occurring at this time. Interestingly,
insertion of needle into tissues.
53.9% of all emergencies reported by Malamed were
3. Determine whether to warm the anesthetic cartridge
fainting, and over 54% of all emergencies occurred
and/or syringe.
during the administration of the local anesthetic.
4. Position the patient (supine recommended).
Syncope during injection can be prevented virtually
5. Dry the tissue.
100% of the time by following a few simple steps to
6. Apply topical antiseptic (optional).
make all local anesthetic injections as comfortable
7a. Apply topical anesthetic (minimum 12 minutes).
(atraumatic) as is possible (Table 9-2). Although all of
7b. Communicate with the patient.
the steps are important, three stand out: (1) placement
8. Establish a firm hand rest.
of the patient who is to receive an intraoral local anes-
9. Make the tissue taut.
thetic into the supine position before the injection, (2)
10. Keep syringe out of the patients line of sight.
the slow administration of the local anesthetic solu-
11a. Insert needle into the mucosa.
tion, and (3) the use of conscious sedation before the
11b. Watch and communicate with the patient.
administration of the local anesthetic.
12. Slowly advance the needle toward target.
The very simple concept behind the successful use of
13. Deposit several drops of local anesthetic before
conscious sedation is that fearful patients are overly
touching periosteum.
focused on everything that happens to them in the den-
14. Aspirate.
tal chair. Simply by administering a drug (central nerv-
15a. Slowly deposit local anesthetic solution.
ous system depressant) that takes the patients aware-
15b. Communicate with the patient.
ness away from the dental milieu, the patient no longer
16. Slowly withdraw syringe. Make needle safe and
over-responds to stimulation, does not care about the
discard.
procedure, and in effect becomes a normal patient.
17. Observe patient after injection.
The administration of inhalation sedation with
18. Record injection on the patients chart.
nitrous oxide and oxygen (N2OO2), carefully titrat-
ed, alleviates any fears of injections in the majority of Adapted from Malamed SF.57
amnesia, the patient having no recall of events occur- Table 9-3 Teeth Requiring Supplemental Injections
ring during their treatment (it didnt happen).
Maxillary: Maxillary: Mandible: Mandible:
Because of the prevalence of fear in endodontic
Teeth Walton Malamed Walton Malamed
patients, the use of conscious sedation should become
increasingly more popular. Unfortunately, the use of Anteriors 2% 2% 9% 0%
conscious sedation by endodontists is extremely rare. Premolars 18% 2% 12% 0%
The benefits to be gained from the proper use of con- Molars 12% 5% 47% 91%
scious sedation greatly outweigh the very slight risks
Adapted from Walton RE and Abbott BJ55; Malamed SF.56
involved with their use.
*VAS = visual analog scale, a rating of pain sensation. A score of 0: felt nothing; 1: minor, no problem; 3: some discomfort; 10:
worst pain ever experienced.
depth description of these techniques, the reader is as the IANB. Additionally, the GGMNB provides senso-
referred to local anesthesia textbooks by Malamed57 ry anesthesia of the buccal nerve as well as the mylohy-
and Jastak and Yagiela.58 oid nerve, eliminating one cause of partial anesthesia
Inferior Alveolar Nerve Block (IANB) (Table 9-4). seen in mandibular first molars in approximately 1% of
This traditional mandibular nerve block provides, patients.
when successful, pulpal anesthesia of all mandibular Local anesthetic is deposited on the lateral aspect of
teeth in the quadrant, along with buccal soft tissues and the neck of the mandibular condyle (Figure 9-45). V3 has
bone anterior to the mental foramen and the lingual just exited the foramen ovale and, with the patients
soft tissues and anterior two-thirds of the tongue. mouth maintained in a wide-open position, the nerve
Many approaches exist to this technique, all of which lies near the condylar neck. First discussed in 1973, the
are acceptable, with two provisos: (1) the success rate GGMNB has slowly become more and more popular.
for pulpal anesthesia should be at least 85% (with one Once learned, the GGMNB will provide a greater success
injection depositing approximately 1.5 mL of anesthet- rate for mandibular pulpal anesthesia.61 Unfortunately, a
ic), and (2) the technique should not increase risk of learning curve does exist, and some doctors, frustrated
harm to the patient. by early failures, abandon this excellent technique. The
The aim in the classic Halstad approach to the IANB major problem encountered in learning the GGMNB is
is to deposit local anesthetic at the mandibular fora- the inability to contact bone at the neck of the mandibu-
men, the site where the IA nerve enters the mandibular lar condyle. The primary reason for this failure is closure
canal. Although still taught as the primary mandibular (even slight closure) of the patients mouth while the
technique in most dental schools, the 85% success rate needle is being advanced (Figure 9-46).
for pulpal anesthesia encountered with this technique
is the lowest of any injection administered in dentistry.
The most common reason the IANB is missed is caused
by depositing the anesthetic solution below the
mandibular foramen. As the IA nerve has already
entered into the thick bony canal, pulpal anesthesia is
not produced. The experienced doctor will re-adminis-
ter additional local anesthetic at the site slightly
(5 mm) higher than the initial site. The patient should
be in a supine position during the IANB, but it is rec-
ommended that they be returned to a more upright
(comfortable) position following drug administration
and while awaiting the onset of anesthesia.
Gow-Gates Mandibular Nerve Block5961 (Table 9-5).
The GGMNB is a true third division (V3) nerve block, Figure 9-45 Gow-Gates mandibular block injection needle at the
providing pulpal anesthesia to all mandibular teeth in target area, the lateral aspect of the neck of the condyle. (Courtesy
the quadrant, as well as the same soft tissue distribution of Drs. Colin and Gwenet Lambert.)
As with the IANB, patients receiving the GGMNB ing the midline, into the buccal fold on the side of
should be supine during the injection, but returned to injection at the height of the mucogingival junction of
a more upright, comfortable position at the conclusion the last maxillary molar (this injection is intermediate
of the injection and while awaiting the onset of anes- in height between the GGMNB and IANB). Soft tissue
thesia. It is important that the mouth be maintained in on the lingual aspect of the mandible is penetrated at a
a wide-open position throughout the injection and for site immediately adjacent to the maxillary tuberosity
2 minutes following its completion. and the needle is advanced 25 mm, where the local
Akinosi-Vazirani Mandibular Nerve Block (Closed- anesthetic is deposited. Motor paralysis usually devel-
Mouth Technique)62,63 (Table 9-6). Described in 1977, ops before soft tissue and pulpal anesthesia. The
this mandibular block technique is of benefit in situa- patient, supine during the injection, should be reposi-
tions in which unilateral trismus is present, secondary to tioned more upright (comfortable) following injection
repeated mandibular injections at a previous dental visit. and while awaiting onset of anesthesia.
The patient is unable to open the mouth more than a few Incisive Nerve Block (INB) (Mental NB) (Table 9-7).
millimeters, preventing the administration of intraoral The INB is an underused technique, but one that pro-
local anesthesia, as well as the performance of dental vides pulpal anesthesia to the five mandibular anterior
treatment. Since V3 is both a sensory and motor nerve teeth on a very reliable basis, even in the presence of
(to the muscles of mastication), blockade of V3 provides infection. Soft tissue anesthesia of the lower lip, skin of
relief of the muscle spasm, permitting the patients the chin, and buccal soft tissues anterior to the mental
mouth to open and the planned dental care to proceed. foramen is achieved 100% of the time. Local anesthesia
The teeth are kept lightly in contact throughout the is infiltrated outside the mental foramen and then, with
injection and the cheek is retracted. A long needle, the use of finger pressure, forced into the foramen and
either a 25- or a 27-gauge is placed, with its bevel fac- mandibular canal where the incisive nerve (a terminal
branch of the IA nerve) is located. Pressure should be nerves are located. In some patients, the mesiobuccal
applied to the area for at least 1 minute, preferably 2 (MB) root of the first molar may not be anesthetized
minutes, following deposition of the anesthetic. Lingual with the PSANB but may be anesthetized by an MSA
soft tissues, including the tongue, are not anesthetized nerve block, described in the following paragraph.64
in the incisive nerve block. Should lingual soft tissue Middle Superior Alveolar Nerve Block (MSANB)
anesthesia be required for placement of a rubber dam (Table 9-9). When present, the MSA nerve provides
clamp, it can be achieved painlessly by advancing the pulpal anesthesia to the two premolars and the MB
needle through the already anesthetized buccal papilla root of the first molar (as well as the buccal soft tissues
toward the lingual while depositing small volumes of and bone overlying this area). Advancing the tip of the
local anesthetic en route. With proper technique (eg, needle well above the apex of the second premolar and
finger pressure for 2 minutes), the INB is virtually 100% administering 0.9 mL of anesthetic will provide suc-
successful, painless (there is no need for the needle to cessful anesthesia almost 100% of the time.
contact bone), and can be used successfully from the Anterior Superior Alveolar Nerve Block (ASANB)
outset (there is no learning curve for this injection). (Infraorbital NB) (Table 9-10). In a technique
technically similar to the incisive nerve block (men-
Maxillary Techniques tal) in the mandible, the ASANB provides pulpal anes-
Posterior Superior Alveolar Nerve Block (PSANB) thesia to the incisors, canine, and both premolars on
(Zygomatic NB) (Table 9-8). When successful pul- the side of injection, as well as their overlying soft tis-
pal anesthesia of maxillary teeth is not achieved sues. The ASA is highly successful in the presence of
through supraperiosteal injection, nerve block anesthe- infection (unless the infection is present in the region
sia usually succeeds. PSANB provides consistently reli- of the infraorbital foramen). The needle is inserted into
able pulpal anesthesia to the three maxillary molars, the buccal fold by the first premolar and aimed for the
even in the presence of infection or widely flared infraorbital foramen, which is located by palpation. A
palatal roots. Buccal soft tissues and bone overlying this volume of 0.9 mL of local anesthetic is deposited out-
area are also anesthetized. As no bone is contacted in side the infraorbital foramen and then forced into the
PSANB, the injection is extremely comfortable; howev- foramen by the application of finger pressure for 2
er, the absence of bony contact increases the risk of minutes (1 minute minimally).
developing a hematoma following the injection. This
usually develops when the needle is advanced too far Supplemental Injection Techniques
into the tissues. From the needle penetration site in the Periodontal Ligament (PDL) Injection and Intraliga-
buccal fold by the second maxillary molar, the short mentary Injection (ILI)6567 (Table 9-11). When pul-
needle is advanced to a depth of 16 mm in an inward, pal anesthesia of a single tooth is required, the PDL injec-
upward, and backward direction. This places the needle tion should be considered. This is of special importance
tip into the pterygomaxillary space, where the PSA in the mandible, where nerve block anesthesia is the
norm. In the maxilla, supraperiosteal injection infiltrated permit access to the pulp chamber of a previously sen-
above the apex of any tooth will provide successful pulpal sitive tooth.
anesthesia with a success rate of > 95%. Because of the Two contraindications exist to administration of the
thickness of the mandibular cortical plate of bone (in PDL injection: primary teeth and the presence of peri-
adults), infiltration techniques are doomed to failure. odontal infection. The presence of pocket infection in
Therefore, although the PDL may be successfully admin- the site of needle insertion increases the risk of
istered to any tooth, its use is most often reserved for osteomyelitis developing subsequent to the injection
mandibular teeth, specifically mandibular molars. (Figure 9-49).
Although special syringes have been developed to Intraosseous (IO) Anesthesia6871 (Table 9-12). In
assist in delivery of the local anesthetic in the PDL true IO anesthesia, local anesthetic is injected directly
injection, a regular syringe may be used quite effective- into the bone surrounding the root of a tooth.
ly. A volume of 0.2 mL of local anesthetic solution must Conceptually the IO injection is quite simple: the
be deposited interproximally on each root of the tooth impediment to local anesthetic diffusion through bone
to be treated. The bevel of the needle should be placed in the adult mandible is the thickness of the cortical
against the root of the tooth while it is advanced down plate. Where a foramen is present, such as the mental
into the PDL space until resistance prevents any further foramen, the drug can gain access to the nerve and pro-
penetration (Figure 9-47 and Figure 9-48). As the anes- duce conduction blockade. Unfortunately, no such
thetic is slowly deposited, it should be noted that there foramen is found on the buccal aspect of the mandible
is significant resistance to the administration of the distal to the mental foramen, making it more difficult
solution and that the soft tissues in the area become to obtain consistently reliable pulpal anesthesia on
ischemic. Presence of these two signs usually connotes mandibular molars (see Table 9-3).
successful anesthesia. Onset of clinical action is imme- In the IO technique, a small perforation or foramen
diate; however, the duration of pulpal anesthesia is is made through the cortical plate of bone with a tiny
quite variable, although it is most often long enough to dental bur, into which a needle is inserted and local
Figure 9-47 Needle penetrating distal periodontal ligament space Figure 9-48 Insertion of needle for periodontal ligament injec-
of mandibular molar. (Courtesy of Drs. Colin and Gwenet tion. a, Correct insertion, bevel faces cribriform plate. b, Incorrect
Lambert.) insertion directing stream toward tooth. (Courtesy of Drs. Colin
and Gwenet Lambert.)
Figure 9-49 Damage and repair to periodontal structures from intraligamental injection. A, Needle tract from lower right into gouged
cementum, top left. Chips of cementum (C), erythrocytes (E), and debris (D) carried in by needle indicate severity at time of injury. B, Tissue
repair 25 days after intraligamental injection. New bone (arrows) has replaced bone resorbed following injection. Reproduced with permis-
sion from Walton RE, Garnick JJ. JOE 1982;8:22.
anesthetic is administered. Intraosseous injections can ing the IO injection. Use of a vasopressor-containing
provide anesthesia of but a single tooth or of multiple local anesthetic in a patient with significant cardiovas-
teeth in a quadrant, depending on the site of injection cular disease could provoke potentially life-threatening
and the volume of anesthetic administered. When complications. It is recommended that a plain non-
treating one or two teeth, 0.45 to 0.6 mL is usually used. epinephrine local anesthetic solution be used in the IO
IO anesthesia has proved to be of great benefit in technique.
endodontics when traditional injection techniques fail. Intrapulpal Anesthesia72 (Table 9-13). When the
Nusstein et al. found that 81% of mandibular and 12% pulp chamber has been exposed and, because of exqui-
of maxillary teeth in 51 patients diagnosed with irre- site sensitivity, treatment cannot proceed, intrapulpal
versible pulpitis required IO anesthesia because of fail- anesthesia should be considered. With the increased
ure to gain pulpal anesthesia with infiltration or IA interest in the very successful IO technique, however,
nerve block. IO anesthesia was found to be 88% suc- the need for intrapulpal anesthesia should diminish.
cessful in gaining total pulpal anesthesia for endodon- A small needle is inserted into the pulp chamber
tic therapy.70 until resistance is encountered (Figure 9-50). The local
Parente et al. administered IO anesthesia to 37 anesthetic must be injected under pressure. There will
patients with irreversible pulpitis.71 Thirty-four were be a brief moment of intense discomfort as the injec-
mandibular molars, 2 were maxillary molars, and 1 was tion is started, but anesthesia usually supervenes almost
a maxillary anterior tooth. Maxillary teeth received immediately, and instrumentation can proceed pain-
infiltration anesthesia, whereas mandibular teeth lessly. Because of the discomfort involved in intrapulpal
received the IA injection with a minimum of 3.6 mL of anesthesia, the patient must be advised of this before the
local anesthetic. IO anesthesia successfully provided injection is begun. The concurrent administration of
pulpal anesthesia in 91% of mandibular molars inhalation sedation (N2OO2) or intravenous Versed
(31/34) and for two of three maxillary teeth. will minimize patient response by alleviating the PRT.
There are two concerns regarding the IO injection.
First, the local anesthetic is administered into a highly Summary
vascular site, where absorption into the cardiovascular Clinically effective pain control can be achieved in the
system is quite rapid. Administration of an overly large vast majority of patients requiring endodontic therapy.
volume of local anesthetic could lead to elevated blood When problems achieving pain control occur, it is usu-
levels of the anesthetic and signs and symptoms of ally at the initial visit, when a frightened patient, who
overdose. The second concern regards the inclusion of has been hurting for some period of time, finally seeks
vasopressors (eg, epinephrine) in the local anesthetic relief from pain yet oftentimes is unable to manage the
solution. This can lead to a rapid absorption into the fears of dentistry. Through a combination of thought-
cardiovascular system leading to an epinephrine reac- ful caring for the patient, the use of conscious sedation,
tion in which patients experience mild tremors of the when indicated, and the effective administration of
extremities, palpitations, and diaphoresis after receiv- local anesthesia, endodontic treatment can proceed in
place. This technique permits the exposure of addition- cannot be easily corrected by periodontal therapy.
al root surface for the placement of the rubber dam Gross subgingival caries may be better treated by the
clamp and final restoration. In some cases, corrective cementation of a copper band custom fitted to the par-
osseous recontouring may be necessary (Figure 9-51). ticular carious defect (Figure 9-52). The extraction of a
partially erupted third molar may leave a bony defect
Copper Bands and a deep carious lesion on the distal root of the sec-
The preceding periodontal procedures are expedient ond molar (Figure 9-53). A copper band may be readi-
and can usually be limited to the endodontically ly adapted to extend subgingivally in this area, where
involved tooth. However, there are some problems that anatomic considerations preclude definitive periodon-
A B
D
Figure 9-51 A, Preoperative view of maxillary canine whose crown is totally destroyed by caries under defective bridge abutment. Level of
gingival tissue (arrow) in relation to remaining root is apparent. B, View following root canal therapy and apical repositioning of attached
gingiva. Elongation of clinical crown is seen (arrow) in comparison with view in A. C, View of final restoration. Important canine abutment
(arrow) is salvaged by combined endodonticperiodontic procedures. (Restoration by Dr. James Haberman.) D, Retrofilling of pulpless
canine abutment was done during mucogingival surgery. Previous endodontic filling was incomplete. (Endodonticperiodontic therapy by
Dr. Edward E. Beveridge.)
Figure 9-52 A, Badly broken-down pulpless molar with root resorption. Before endodontic treatment, cavity must be sealed off. B,
Custom-fitted copper band allows for full treatment. (Courtesy of Dr. James D. Zidell.)
tal therapy. In severe cases, the periodontal or carious dam applications have been developed. In all but the
defect may be beyond repair, requiring hemisection of most unusual circumstances, the rubber dam can be
the distal root of the lower second molar. Banding may placed in less than 1 minute.
then be helpful to seal off the bisected pulp chamber. Although the modern endodontic approach to the
use of the dam has changed, the importance and pur-
Orthodontic Bands poses of the dam remain the same:
Whereas the copper band is custom-fitted to adapt to a
carious defect extending well below the gingival mar- 1. It provides a dry, clean, and disinfected field.
gin, the orthodontic band is prefabricated to fit the 2. It protects the patient from the possible aspiration
tooth supragingivally. Thus, it is not used to replace the or swallowing of tooth and filling debris, bacteria,
copper band but to help retain a large temporary filling necrotic pulp remnants, and instruments or operat-
or support a tooth with undermined enamel walls. It is ing materials7678 (Figure 9-55).
an essential step in the treatment of a tooth that is 3. It protects the patient from rotary and hand instru-
thought to be cracking or split (Figure 9-54). It serves ments, drugs, irrigating solutions, and the trauma of
as an excellent temporary restoration to prevent split- repeated manual manipulation of the oral soft tissues.
ting during extended treatment, or after treatment,
when final restoration has to be postponed. All bands
are cemented with zinc oxyphosphate cement.
Temporary Crowns and Restorations
Aluminum shell crowns and plastic crowns or bridges
cemented with zinc oxideeugenol cement are not
acceptable as proper pretreatment temporization. The
placement of the rubber dam clamp and the tension of
the rubber dam displace these temporary crowns, as
does repeated rubber dam application and endodontic
manipulation. In addition, access attempted through
the temporary crown and cement may easily be misdi-
rected against one of the axial walls of the preparation
instead of directly into the pulp chamber.
RUBBER DAM APPLICATION
Rubber dam application is an essential prerequisite for Figure 9-53 Destruction caused by partially erupted third molar
providing nonsurgical endodontic treatment. For root and caries. Extended copper band will isolate crown for endodontic
canal treatment, rapid, simple, and effective methods of treatment. (Courtesy of Dr. James D. Zidell.)
*This most important point bears emphasis. All of the dental office
Figure 9-56 Oraseal ejected from tube seals tear in rubber dam, personnel should have nose cultures, and if staphylococci are pres-
despite moisture from saliva. (Courtesy of Ultradent Prod., USA.) ent, should apply Neosporin or Mycitracin to their nostrils each day.
Table 9-14 Rubber Dam Clamp Selection lished on the effect of rubber dam retainers on the sur-
face of porcelain. One study reported that damage to
Maxillary Teeth
the porcelain surface resulted when metal rubber dam
Central incisor Ivory 00 or 2, 212 or 9A,
retainers were in contact with porcelain-fused-to-metal
Hu-Friedy 27, Ash A
(PFM) restorations.84 Another study demonstrated
Lateral incisor Ivory 00, 212 or 9A, Ash C
that neither the broad contact of a plastic retainer beak
Canine Ivory 2 or 2A, 212 or 9A
nor the point contact under a metal retainer beak dam-
Premolars Ivory 2 or 2A, Hu-Friedy 27
aged the contact area of porcelain surface of a PFM
Molars Ivory 3 or 4, Ivory 8A, 12A or 13A,
cylinder.85 However, repeated applications of rubber
14 or 14A, Ash A
dam clamps, in multiple appointments necessary to
Mandibular Teeth complete endodontic procedures, is likely to increase
Incisors Ivory 0 or 00, 212 or 9A, Ash C the risk of damage.
Canine Ivory 2 or 2A, 212 or 9A For endodontic treatment particularly, the use of
Premolars Ivory 2 or 2A, Hu-Friedy 27 clamps with wings allows a more rapid, efficient means
Molars Hu-Friedy 18, Ivory 8A, 12A or of applying the rubber dam. A well-trained assistant is
13A, 14 or 14A, 26, Ash A, able to perform much of the usual technical procedure
fatigued Ivory 2A of application described later in this section. The wings
allow the dentist to place the clamp, dam, and frame in
one operation (Figure 9-59). In addition, the wings
Plastic clamps (Moyco/Union Broach, USA) are cause a broader buccal-lingual deflection of the dam
also available in two sizes, large and small, and are from the involved tooth, allowing increased access.
used in selected cases. When metal clamp obstruction Rubber dam clamps undergo stress with repeated
is a problem in radiography, radiolucent plastic use and sterilization. Additionally, clamps that are used
clamps allow for an unobstructed view of the tooth. during endodontic procedures may be chemically
Plastic clamps can also be used to isolate teeth during stressed and subject to fracture if in contact with the
vital tooth bleaching, using a heat lamp to avoid irrigant sodium hypochlorite.86 It is a good safety
excessive heat buildup that occurs with conventional measure to place dental floss ligatures around both
metal clamps. ends of the clamp bows so that if the clamp fractures,
Metal rubber dam clamps may damage tooth struc- both portions can be retrieved.
ture, restorations, and the porcelain surface of crowns Forceps. Either the Ash- or Ivory-style clamp for-
or veneers. Conflicting reports have recently been pub- ceps is satisfactory. One advantage of the Ivory forceps,
A B
Figure 9-58 Le Cadre Articul rubber dam frame. A, In closed position, frame is curved to fit face. B, Open position, from either side, allows
passage of radiographic film holder. (Courtesy of Jored, Ormoy, France, and Trophy, USA.)
Technique of Application
Three methods of applying a rubber dam, two for a
single-bowed clamp and one for a double-bowed
clamp, are described in the following sections.
Assistant.
however, is the projections from the engaging beaks. 1. Punch one appropriate-sized hole just off center of
These allow the operator the opportunity to exert a a 6 inch 6 inch piece of dam material. Rotate the
gingivally directed force, which is often necessary to dam to match the tooth to be treated: upper or
direct the clamp beyond the height of contour and into lower, right or left. Traditionally, only the teeth
proximal undercuts. receiving therapy should be included in the dam
The projections on the beaks also allow positive con- application.
trol, enabling the jaws of clamps to be tipped to depress 2a. Stretch the dam over the frame and place the wings
either the toe or heel of the clamp. The Ash-style of the selected clamp in the punched hole with the
forceps beaks, on the other hand, afford a fulcrum bow of the clamp to the distal (Figure 9-60), or
point for posterior or anterior rotation of the clamp. 2b. Place only the bow of the clamp through the
Tucking Instrument. A plastic or cement instru- punched hole of the rubber dam.
ment is used to shed the rubber dam off the wings of 3. Place the forceps in the clamp holes with tension and
the clamp once the clamp has been positioned. It is also hold in readiness for the dentist (see Figure 9-60).
used, along with a stream of air, to invert or tuck the
edges of the dam into the gingival sulci, thus ensuring Application by the Team Dentist.
a moisture-proof seal. This is particularly necessary in 4. Place an index finger in the vestibule to retract the
multiple-tooth applications. lip and cheek. The patient is instructed to place the
Dental Floss. At one time it was recommended tongue on the opposite side.
that dental floss be routinely used as a ligature placed 5. Sight the tooth to be clamped between the jaws of
around the cervix of each tooth to invert or tuck the the clamp (Figure 9-61, A). Direct vision is essential.
dam and provide a seal. Through the use of medium or 6. Place the clamp into the cervical proximal under-
heavy dam material, this is no longer necessary. Floss is cuts on the tooth as the index finger is removed
still essential, however, for the testing of contacts from the vestibule (Figure 9-61, B). Finger pressure
before dam application and for passing the dam mate- is sometimes used to ensure seating of the clamp
rial through the contacts. In both instances, the opera- 7a. For 2a above, shed the dam off the clamp wings
tor should release his lingual grasp of the floss and pull with the tucking instrument (Figure 9-61, C). Care
it out to the buccal, rather than back through the con- is taken not to rip the dam, or
tact point. 7b. For 2b above, loosely apply the rubber dam frame
Saliva Ejector. Any disposable/radiolucent saliva to the corners of the rubber dam with the aid of the
ejector is acceptable. It should always be placed under- assistant. Then stretch the dam under the wings of
neath the dam for endodontic use, in contrast to the the clamp with the tucking instrument and tighten
procedure of cutting a hole through the dam. This will the rubber dam over the entire frame.
Figure 9-61 A, Dentist retracts lip and cheek with thumb and index finger of left hand and sites tooth to be clamped (here a maxillary pre-
molar) between bows of the clamp. Care must be taken not to clamp wrong tooth. B, Clamp is carried into gingival undercuts. If undercuts
are slight, clamp may be rotated on tooth to take advantage of undercuts along labial and lingual-proximal long axis. C, Dam is shed from
clamp wings with tucking instrument, which is also used to carry lip of dam under gingival sulcus after tooth is air-dried. D, Dental floss is
used to carry dam past interproximal contacts. Floss should then be pulled to buccal rather than removed back past contact.
A B
Figure 9-62 A, Rubber dam in place, exposing involved tooth previously marked with a marking pen. B, Clamp placement in gingival
undercuts. Dental floss carries dam past interproximal contacts and is removed by pulling to buccal rather than back through contacts.
(Courtesy of Jeffrey M Coil.)
ensure that no interproximal dam septum has been Fourth Circumstance. Partially erupted tooth.
left between the teeth. Variation. An Ivory #14A or Ash #A clamp forced
subgingivally into the cervical undercut will often hold.
Circumstances Requiring Variations from the On occasion, an Ash #C clamp, placed on the oblique,
Usual Application will suffice. For supragingival retention, when no
A number of circumstances require a variation from undercut is present, Japanese researchers have recom-
the standard dam application. mended placing a small amount of self-curing compos-
First Circumstance. A well-done gingival gold fill- ite resin on the labial and lingual unetched enamel sur-
ing or PFM veneer crown on the involved tooth that faces. The clamp is set in this scaffold of the cured resin.
could be damaged by clamps. After use, the resin can be lifted off with an excavator.91
Variation. Clamp one tooth posterior to, and Fifth Circumstance. Caries, resulting in a subgin-
extend the rubber dam one tooth anterior to, the gival restorative margin of the involved tooth (Figure
involved tooth. 9-64, A).
Second Circumstance. Multiple adjacent teeth Variation. Clamp one tooth posterior to, and
requiring treatment. extend rubber dam one or two teeth anterior to, the
Variation. The posterior tooth is clamped normally involved tooth. The furthest anterior tooth isolated may
while the clamp is reversed (with the bow pointing receive a rubber dam clamp with its bow pointing
mesially) on the more anterior tooth. By another mesially. If floss shreds through, or the rubber dam rips
approach, the most posterior tooth is clamped normally, between the contacts, Oraseal may be necessary to
while the anterior portion of the dam is retained and develop a fluid seal (Figure 9-64, B). This multiple-tooth
retracted without a clamp. Neaverth has suggested that a isolation facilitates easy placement of an interproximal
1
4-inch-wide strip of dam can be stretched thin to simu-
late dental floss (personal communication, Feb. 2000). It
is then passed through the contact and, when released,
acts as a wedge holding the dam in place (Figure 9-63).
Third Circumstance. Bridge abutments, splints,
and orthodontic bands with wires.
Variation. Punch a larger-than-usual hole in the
dam. Smear Oraseal around the hole on the underside of
the dam. This mucilaginous material prevents leakage.
Clamp the tooth in the normal manner. In addition, place
a round toothpick through the gingival embrasure next
to the pontic. If leakage is still a problem, add more
Oraseal around the abutment at the site of the leakage.
A
B
Figure 9-63 Narrow strip of rubber dam (arrow) passed through Figure 9-64 A, Four-tooth and two-clamp dam isolation in patient
contact point acts as wedge to hold dam anteriorly without addi- with Dilantin hyperplasia. B, Possible leakage toward the buccal and
tional clamp. (Courtesy of Dr. E.J. Neaverth.) lingual is controlled by Oraseal. (Courtesy of Jeffrey M. Coil.)
matrix used during final restoration, without interfer- of displacement, on the bow of the clamp. The clamp
ence from a rubber dam clamp on the involved tooth. may be reversed on the working tooth; a second clamp
Sixth Circumstance. Hemisected maxillary or is placed over the rubber dam on the next tooth poste-
mandibular molars. rior to absorb the pressure of the rubber dam.
Variation. Hemisected mandibular molars are Periodontal crown lengthening to elongate the
treated as a premolar. Those that are wide buccolin- crown of a fractured or badly decayed tooth was dis-
gually are best clamped with a fatigued Hu-Friedy or cussed in the section Endodontic Pretreatment.
Ivory #2 or #2A. Ninth Circumstance. Extensive caries resulting in
A hemisected maxillary molar with the lingual root subgingival buccal and/or lingual margin(s).
remaining is also best treated as a large premolar. A Hu- Variation. The involved tooth can undergo peri-
Friedy #27 clamp frequently adapts well. When the two odontal crown lengthening, addition of restorative
buccal roots of a maxillary molar remain, it is then best material to allow for supragingival clamp placement, or
treated as a small molar, and an Ash #A frequently suf- gingival surgery to expose more tooth structure to
fices. Often the hemisected maxillary molar can be allow for clamp placement (see Figure 9-51).
clamped only by placing the clamp obliquely. Tenth Circumstance. Fractured cusp with subgin-
Seventh Circumstance. Full-crown preparation gival margin on buccal or lingual surface.
without a cervical undercut to retain the clamp. Variation. Use three-tooth rubber dam isolation
Variations. A proper full-crown preparation will as in second circumstance. By placing a short cotton
shed toward the occlusal, and the clamp may not pro- roll under the wing of the rubber dam clamp, addi-
vide adequate resistance to the tension of the rubber tional reflection of the rubber dam can be achieved
dam. It may be necessary to place parallel horizontal (Figure 9-65). Note that the clamp would otherwise be
grooves on the buccal and lingual axial walls of the unstable if placed on the involved tooth in the tradi-
preparation near the gingival margin to permit the tional single-tooth isolation.
clamp to grasp onto the preparation. The Ivory #2 or Eleventh Circumstance. Tooth with calcified pulp
#2A clamp will fit into these grooves for retention. It chamber and canal(s).
has also been suggested that applying composite resin Variation. Use three-tooth rubber dam isolation
on the buccal and lingual unetched surfaces might be as in second circumstance. Involved tooth is without a
superior to cutting grooves.91 clamp, allowing the operator to better visualize the CEJ
Eighth Circumstance. Posterior teeth with mini- region of the tooth. There are no clamp wings to
mal tooth structure for clamp retention. obstruct ones view. A periodontal probe can be traced
Variation. The tension of the rubber dam as it is along the root surface to orientate oneself to the
stretched taut over the frame exerts pressure, or a force crownroot angulations during difficult-access cavity
preparations. Additionally, the image in working films
is unlikely to be obstructed by the clamp (Figure 9-66).
Figure 9-65 Placement of cotton roll (arrow) under the palatal Figure 9-66 Fractured first molar isolated in three-tooth dam
wing of the clamp stretches the dam against the palate, exposing placement with clamp on second molar, allowing unobstructed view
more of the fractured tooth surface. Seal can be augmented with of canal orifices in first molar. Distal canal marked by gutta-percha to
Oraseal. (Courtesy of Jeffrey M. Coil.) visualize correct drilling direction. (Courtesy of Jeffrey M. Coil.)
44. Tahibana H, Matsumoto K. Applicability of x-ray computer- 68. Leonard M. The efficacy of an intraosseous injection system of
ized tomography in endodontics. Endod Dent Traumatol delivering local anesthesia. J Am Dent Assoc 1995;126:81.
1990;6:16. 69. Leonard M. The Stabident System of intraosseous anesthesia.
45. Brynolf I. Improved viewing facilities for better roentgenodi- Dent Econ 1997;87:51.
agnosis. Oral Surg 1971;32:808. 70. Nustein J, Reader A, Nist R, et al. Anesthetic efficacy of the
46. Spiegler G. Wiesollen Rontgenufrahmen Betrachtet Werden? supplemental intraosseous injection of 2% lidocaine with
Forstchr Geb Roentgenstr 1937;56:662. 1:100,000 epinephrine in irreversible pulpitis. JOE
47. Ball KA. Endoscopic surgery. St. Louis (MO): Mosby/Year 1998;24:487.
Book; 1997. p. 1. 71. Parente SA, Anderson RW, Herman WW, et al. Anesthetic effi-
48. Detsch S, Cunninghan W, Langloss J. Endoscopy as an aid to cacy of the supplemental intraosseous injection for teeth
endodontic diagnosis. JOE 1979;5:60. with irreversible pulpitis. JOE 1998;24:826.
49. Held S, Kao Y, Well D. Endoscope B and endodontic applica- 72. Malamed SF, Weine F. Profound pulpal anesthesia [audiotape].
tion. JOE 1996;22:327. Chicago: American Association of Endodontics; 1988.
50. Shulman B, Leung B. Endodscopic surgery: an alternative 73. Bobotis HG, et al. A microleakage study of temporary restora-
technique. Dent Today 1996;15:42. tive materials used in endodontics. JOE 1989;15:569.
51. Bahcall JK, DiFiore PM, Pouladakis TK. An endoscopic tech- 74. Parris L, Kapsimalis P. Effect of temperature change on the
nique for endodontic surgery. JOE 1999;25:132. sealing properties of temporary filling materials. Oral Surg
52. Bahcall JK, Barss JT. Orascopic endodontics: changing the way 1960;13:982.
we think about endodontics in the 21st century. Dent 75. Anderson RW, et al. Microleakage of temporary restorations in
Today 2000;19. complex endodontic access preparations. JOE 1989;15:526.
53. Bahcall JK, Barss JT. Fiberoptic endoscope usage for intracanal 76. Goulschin J, Heling B. Accidental swallowing of an endodon-
visualization. JOE 2001;27:128. tic instrument. Oral Surg 1971;40:621.
54. Malamed SF. Beyond the basics: emergency medicine in den- 77. Gouila CD. Accidental swallowing of an endodontic instru-
ment. Oral Surg 1979;48:269.
tistry. J Am Dent Assoc 1997;128:843.
78. Lambrainidis T, Bettes P. Accidental swallowing of endodontic
55. Walton RE, Abbott BJ. Periodontal ligament injection: a clini-
instruments. Endod Dent Traumatol 1996;12: 301.
cal evaluation. J Am Dent Assoc 1981;103:571.
79. Friedman S, Torneck CD. In vivo model for assessing the func-
56. Malamed SF. Teeth requiring supplemental injections.
tionally efficacy of endodontic filling materials and tech-
Unpublished data, 1997.
niques. JOE 1997;23:557.
57. Malamed SF. Handbook of local anesthesia. 4th ed. St. Louis
80. Roy A, Epstein J, Onno E. Latex allergies in dentistry: recogni-
(MO): Mosby; 1997.
tion and recommendations. J Can Dent Assoc 1997;63:297.
58. Jastak JT, Yagiela JA. Local anesthesia of the oral cavity.
81. Fors UGH, Berg J-O, Sandberg H. Microbiological investiga-
Philadelphia: WB Saunders; 1995.
tion of saliva leakage between rubber dam and tooth dur-
59. Gow-Gates GAE. Mandibular conduction anesthesia: a new
ing endodontic treatment. JOE 1986;12:396.
technique using extraoral landmarks. Oral Surg 82. Roahen JO, Lento CA. Using cyanoacrylate to facilitate rubber
1973;36:321. dam isolation of teeth. JOE 1992;18:517.
60. Malamed SF. The Gow-Gates mandibular nerve block: evalua- 83. Bramwell JD, Hicks ML. Solving isolation problem with rub-
tion after 4275 cases. Oral Surg 1981;51:463. ber base adhesive. JOE 1986;12:363.
61. Jofre J, Munzenmayer C. Design and preliminary evaluation of 84. Madison S, Jordan RD, Krell KV. The effects of rubber dam
an extraoral Gow-Gates guiding device. Oral Surg retainers on porcelain-fused-to-metal restorations. JOE
1998;85:661. 1986;12:183.
62. Akinosi JO. A new approach to the mandibular nerve block. Br 85. Zerr MA, Johnson WT, et al. Effect of rubber dam retainers on
J Oral Surg 1977;15:83. porcelain-fused-to-metal. Gen Dent 1996;44:132.
63. Vasirani SJ. Closed mouth mandibular nerve block: a new 86. Sutton J, Saunders WP. Effect of various irrigant and autoclav-
technique. Dent Dig 1960;66:10. ing regimes on the fracture resistance of rubber dam
64. Loetscher CA, Melton DC, Walton RE. Injection regimen for clamps. Int Endod J 1996;29:333.
anesthesia of the maxillary first molar. J Am Dent Assoc 87. Mejia JL, Donado JE, Posada A. Accidental swallowing of a
1988;117:337. rubber dam clamp. JOE 1996;22:619.
65. Malamed SF. The periodontal ligament (PDL) injection: an 88. Alexander RE, Delhom JJ. Rubber dam clamp ingestion, an
alternative to inferior alveolar nerve block. Oral Surg operative risk: report of a case. J Am Dent Assoc
1982;53:117. 1971;82:1387.
66. Brannstrom M, Lindskog S, Nordenvall KJ. Enamel hypoplasia 89. Beemster G. Unusual position for a rubber dam clamp. Oral
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Chapter 10
ENDODONTIC CAVITY PREPARATION
John I. Ingle, Van T. Himel, Carl E. Hawrish, Gerald N. Glickman,
Thomas Serene, Paul A. Rosenberg, L. Stephen Buchanan, John D. West,
Clifford J. Ruddle, Joe H. Camp, James B. Roane, and Silvia C. M. Cecchini
The chapter on success and failure (chapter 13) sub- CORONAL CAVITY PREPARATION
stantiates the endodontic dogma of careful cavity Basic Coronal Instruments
preparation and canal obturation as the keystones to
successful root canal therapy. Apical moisture-proof Preparations on and within the crown are completed
seal, the first essential for success, is not possible unless with power-driven rotary instruments. For optimal
the space to be filled is carefully prepared and dbrided operating efficiency, separate ranges of bur speed are
to receive the restoration. As in restorative dentistry, needed. Although two handpieces are usually required,
the final restoration is rarely better than the initial developments in electric handpiece engineering allow
cavity preparation. one motor to provide both low- and high-speed ranges
Endodontic cavity preparation begins the instant the of rpm. Handpieces are also being developed that auto-
involved tooth is approached with a cutting instru- matically reverse on lockage of the file.2
ment, and the final obturation of the canal space will The correct burs are mounted by the dental assistant
depend in great measure on the care and accuracy exer- prior to their use. Rarely should a bur have to be placed
cised in this initial preparation. or changed during the operation. For initial entrance
through the enamel surface or through a restoration, the
DIVISIONS OF CAVITY PREPARATION ideal cutting instrument is the round-end carbide fis-
For descriptive convenience, endodontic cavity prepa- sure bur such as the Maillefer Transmetal bur or Endo
ration may be separated into two anatomic divisions: Access diamond stone (Dentsply/Maillefer, Tulsa, Okla.),
(a) coronal preparation and (b) radicular preparation. mounted in a contra-angle handpiece operating at accel-
Actually, coronal preparation is merely a means to an erated speed. With this instrument, enamel, resin,
end, but to accurately prepare and properly fill the ceramic, or metal perforation is easily accomplished, and
radicular pulp space, intracoronal preparation must be surface extensions may be rapidly completed.
correct in size, shape, and inclination. Porcelain-fused-to-metal restorations, however, are
If one thinks of an endodontic preparation as a con- something else. Stokes and Tidmarsh have shown the
tinuum from enamel surface to apex, Blacks principles effectiveness of various bur types in cutting through dif-
of cavity preparationOutline, Convenience, ferent types of crowns3 (Figure 10-2). Precious metal
Retention, and Resistance Formsmay be applied alloys are relatively easy to penetrate, whereas non-
(Figure 10-1).1 The entire length of the preparation is precious metals present considerable difficulty. Although
the full outline form. In turn, this outline may have to nonprecious alloys can be cut with tungsten carbide burs,
be modified for the sake of convenience to accommo- they chatter severely. This vibration results in patient
date canal anatomy or curvature and/or instruments. discomfort and tends to loosen the crown from the luting
In some techniques, the canal may be prepared for cement. The extra coarse, dome-ended cylinderwas
slight retention of a primary gutta-percha point. But the only bur type that cut smoothly and remained clini-
most important, resistance must be developed at the cally effective during the cutting of five successive access
apical terminus of the preparation, the so-called apical cavities in the nonprecious metal found frequently
stop, the barrier against which virtually every canal under metal-ceramic crowns.3 Teplitsky and Sutherland
filling must be compacted. also found diamond instrumentation perfect for access
Figure 10-2 Comparison of round tungsten carbide burs versus extra-coarse dome-ended cylinder diamond burs used to cut nonprecious
alloys. A, Tungsten carbide round bur before use. B, Same bur after preparing five cavities. C, Extra-coarse diamond bur before use. D, Same
after preparing two cavities. Loss of abrasive on dome end. Tungsten carbide burs always chattered. The coarse diamond bur was the only
one that cut smoothly and remained clinically effective during five successive cavity preparations. Reproduced with permission from
Stokes AN and Tidmarsh BG.3
by sight alone and is not generally employed in a blind two-dimensional blueprint of pulp anatomy. It is the
area where reliance on tactile sensation is necessary. third dimension that the clinician must visualize, as a
supplement to two-dimensional thinking, if one is to
Pulp Anatomy in Relation to Cavity Preparation clean and shape accurately and fill the total pulp space
The alliance between endodontic cavity preparation (Plate 1, A).
and pulp anatomy is inflexible and inseparable. To Often the number or anatomy of the canals dictates
master the anatomic concept of cavity preparation, the modifications of the cavity preparation. If, for example,
operator must develop a mental, three-dimensional a fourth canal is found or suspected in a molar tooth,
image of the inside of the tooth, from pulp horn to api- the preparation outline will have to be expanded to
cal foramen. Unfortunately, radiographs provide only a allow for easy, unrestrained access into the extra canal.
dentin of the pulpal roof and walls overhanging the convenience in the placement of intracoronal restora-
floor of the chamber (Plate 1, B). tions. In endodontic therapy, however, convenience
This intracoronal preparation is contrasted to the form makes more convenient (and accurate) the prepa-
extracoronal preparation of operative dentistry, in ration and filling of the root canal. Four important
which outline form is always related to the external benefits are gained through convenience form modifi-
anatomy of the tooth. The tendency to establish cations: (1) unobstructed access to the canal orifice, (2)
endodontic outline form in the conventional operative direct access to the apical foramen, (3) cavity expansion
manner and shape must be resisted (Plate 1, C). to accommodate filling techniques, and (4) complete
To achieve optimal preparation, three factors of authority over the enlarging instrument.
internal anatomy must be considered: (1) the size of Unobstructed Access to the Canal Orifice. In
the pulp chamber, (2) the shape of the pulp chamber, endodontic cavity preparations of all teeth, enough
and (3) the number of individual root canals, their cur- tooth structure must be removed to allow instruments
vature, and their position. to be placed easily into the orifice of each canal without
Size of Pulp Chamber. The outline form of interference from overhanging walls. The clinician
endodontic access cavities is materially affected by the must be able to see each orifice and easily reach it with
size of the pulp chamber. In young patients, these the instrument points. Failure to observe this principle
preparations must be more extensive than in older not only endangers the successful outcome of the case
patients, in whom the pulp has receded and the pulp but also adds materially to the duration of treatment
chamber is smaller in all three dimensions (Plate 1, D). (Plate 2, A to D).
This becomes quite apparent in preparing the anterior In certain teeth, extra precautions must be taken to
teeth of youngsters, whose larger root canals require search for additional canals. The lower incisors are a
larger instruments and filling materialsmaterials case in point. Even more important is the high inci-
that, in turn, will not pass through a small orifice in the dence of a second separate canal in the mesiobuccal
crown (Plate 1, E). root of maxillary molars. A second canal often is
Shape of Pulp Chamber. The finished outline form found in the distal root of mandibular molars as well.
should accurately reflect the shape of the pulp chamber. The premolars, both maxillary and mandibular, can
For example, the floor of the pulp chamber in a molar also be counted on to have extra canals. During
tooth is usually triangular in shape, owing to the trian- preparation, the operator, mindful of these variations
gular position of the orifices of the canals. This triangu- from the norm, searches conscientiously for addi-
lar shape is extended up the walls of the cavity and out tional canals. In many cases, the outline form has to
onto the occlusal surface; hence, the final occlusal cavity be modified to facilitate this search and the ultimate
outline form is generally triangular (Plate 1, C). As cleaning, shaping, and filling of the extra canals
another example, the coronal pulp of a maxillary pre- (Figure 10-5).
molar is flat mesiodistally but is elongated buccolingual- Luebke has made the important point that an entire
ly. The outline form is, therefore, an elongated oval that wall need not be extended in the event that instrument
extends buccolingually rather than mesiodistally, as does impingement occurs owing to a severely curved root or
Blacks operative cavity preparation (Plate 1, F). an extra canal (personal communication, April 1983)
Number, Position, and Curvature of Root Canals. (Plate 1, G). In extending only that portion of the wall
The third factor regulating outline form is the number, needed to free the instrument, a cloverleaf appearance
position, and curvature or direction of the root canals. may evolve as the outline form. Hence, Luebke has
To prepare each canal efficiently without interference, termed this a shamrock preparation (Plate 1, H).
the cavity walls often have to be extended to allow an It is most important that as much crown structure
unstrained instrument approach to the apical foramen. be maintained as possible. MOD cavity preparations
When cavity walls are extended to improve instrumen- reduce tooth stiffness by more than 60%, and the
tation, the outline form is materially affected (Plate 1, loss of marginal ridge integrity was the greatest con-
G). This change is for convenience in preparation; tribution to loss of tooth strength.7
hence, convenience form partly regulates the ultimate Direct Access to the Apical Foramen. To provide
outline form. direct access to the apical foramen, enough tooth struc-
ture must be removed to allow the endodontic instru-
Principle II: Convenience Form ments freedom within the coronal cavity so they can
Convenience form was conceived by Black as a mod- extend down the canal in an unstrained position. This
ification of the cavity outline form to establish greater is especially true when the canal is severely curved or
PLATE 1
Outline Form
A. A standard radiograph (left) in buccolingual pro- triangular preparation in a youngster reflects pul-
jection provides only a two-dimensional view of pal horn extension and size of the pulp chamber,
what is actually a three-dimensional problem. If a whereas ovoid preparation in an adult relates to a
mesiodistal x-ray projection could be made grossly receded pulp. Extension toward the incisal
(right), one would find the pulp of the maxillary allows central-axis access for instruments.
second premolar to be flat tapering ribbon rather E. Large size and shape of coronal preparation in a
than round thread visualized on the initial radi- recently calcified incisor relate to huge pulp hous-
ograph. The final ovoid occlusal cavity preparation ing. To remove all pulp remnants and to accom-
(F) will mirror the internal anatomy rather than modate large endodontic instruments and filling
the buccolingual x-ray image. materials, coronal preparation must be an exten-
B. Coronal preparation of a maxillary first molar sive, triangular, funnel-shaped opening. Actually,
illustrating the major principle of endodontic cav- no more than the lingual wall of pulp chamber has
ity outline form: the internal anatomy of the tooth been removed. In lower incisors, the outline form
(pulp) dictates the external outline form. This is may well be extended into the incisal edge. This
accomplished by extending preparation from preparation allows absolutely direct access to apex.
inside of the tooth to the outside surface, that is, F. The outline form of the endodontic coronal cavity
working from inside to outside. in the maxillary first premolar is a narrow, elon-
C. Endodontic cavity preparation, mandibular first gated oval in buccolingual projection (bottom),
molar, superimposed on inlay, restoring proxi- which reflects the size and shape of a broad, flat
mal-occlusal surfaces. Blacks outline form of pulp chamber of this particular tooth.
inlay is related to the external anatomy and envi- G. Buccal view of an inadequate coronal preparation
ronment of the tooth, that is, the extent of carious in a maxillary molar with a defalcated mesiobuccal
lesions, grooves, and fissures and the position of root. There has been no compensation in cavity
the approximating premolar. A triangular or preparation for severe curvature of the mesial canal
rhomboidal outline form of endodontic prepara- or for the obtuse direction by which the canal
tion, on the other hand, is related to the internal leaves the chamber. The operator can no longer
anatomy of the pulp. No relationship exists maintain control of the instrument, and a ledge has
between the two outline forms. been produced (arrow). Extension of the outline
D. Size and shape of endodontic coronal preparations form and internal preparation to the mesial (dot-
in mandibular incisors related to size and shape of ted line) would have obviated this failure.
the pulp and chamber. A contrast in outline form H. Shamrock preparation. Modified outline form to
between a young incisor (left) with a large pulp accommodate the instrument unrestrained in the
and an adult incisor (right) is apparent. The large severely curved mesial canal seen in G.
Figure 10-5 Rogues Gallery of aberrant canals, bifurcations, and foramina, all cleaned, shaped, and obturated successfully. (Courtesy of
Drs. L. Stephen Buchanan and Clifford J. Ruddle.)
leaves the chamber at an obtuse angle (Plate 2, E). Failure to properly modify the access cavity outline
Infrequently, total decuspation is necessary. by extending the convenience form will ultimately lead
Extension to Accommodate Filling Techniques. It to failure by either root perforation, ledge or shelf
is often necessary to expand the outline form to make formation within the canal, instrument breakage, or
certain filling techniques more convenient or practical. the incorrect shape of the completed canal preparation,
If a softened gutta-percha technique is used for filling, often termed zipping or apical transportation.
wherein rather rigid pluggers are used in a vertical
thrust, then the outline form may have to be widely Principle III: Removal of the Remaining Carious
extended to accommodate these heavier instruments. Dentin and Defective Restorations
Complete Authority over the Enlarging Instrument. Caries and defective restorations remaining in an
It is imperative that the clinician maintain complete endodontic cavity preparation must be removed for three
control over the root canal instrument. If the instru- reasons: (1) to eliminate mechanically as many bacteria
ment is impinged at the canal orifice by tooth structure as possible from the interior of the tooth, (2) to eliminate
that should have been removed, the dentist will have the discolored tooth structure, that may ultimately lead to
lost control of the direction of the tip of the instru- staining of the crown, and (3) to eliminate the possibility
ment, and the intervening tooth structure will dictate of any bacteria-laden saliva leaking into the prepared cav-
the control of the instrument (Plate 2, G). ity. The last point is especially true of proximal or buccal
If, on the other hand, the tooth structure is removed caries that extend into the prepared cavity.
around the orifice so that the instrument stands free in After the caries are removed, if a carious perforation
this area of the canal (Plate 2, H), the instrument will of the wall is allowing salivary leakage, the area must be
then be controlled by only two factors: the clinicians repaired with cement, preferably from inside the cavity.
fingers on the handle of the instrument and the walls of A small piece of premixed temporary cement, Cavit or
the canal at the tip of the instrument. Nothing is to Cavit G (Premier Dental Products; Plymouth, Pa.), may
intervene between these two points (Plate 2, F). be forced through the perforation and applied to the
dry walls of the cavity, while care is taken to avoid forc- if it is imperative that the tooth be retained, a simple
ing the cement into a canal orifice. A cotton pellet, gingivoplasty will establish the required crown
moistened with any sterile aqueous solution such as length. In any case, this procedure is usually necessary
saline or a local anesthetic, will cause the Cavit to set. before the tooth can be restored. In this case, the
Coronal perforations may also be repaired with adhe- occlusal cavity may be sealed and the incised gingiva
sive composite resins placed by the acid-etch technique protected with the placement of a putty-like periodon-
in a perfectly dry milieu. tal dressing over the entire stump and gingiva. Cotton,
If the caries is so extensive that the lateral walls are and then a thin layer of Cavit, should first cover the
destroyed, or if a defective restoration is in place that is canal orifices.
loose and leaking, then the entire wall or restoration
should be removed and later restored. It is important Principle IV: Toilet of the Cavity
that restoration be postponed until the radicular All of the caries, debris, and necrotic material must be
preparation has been completed. It is much easier to removed from the chamber before the radicular prepa-
complete the radicular preparation through an open ration is begun. If the calcified or metallic debris is left
cavity than through a restored crown. As a matter of in the chamber and carried into the canal, it may act as
fact, the more crown that is missing, the easier the an obstruction during canal enlargement. Soft debris
radicular preparation becomes. The ultimate in ease of carried from the chamber might increase the bacterial
operation is the molar tooth broken off at the gingival population in the canal. Coronal debris may also stain
level (Figure 10-6). As long as a rubber dam can be the crown, particularly in anterior teeth.
placed on the tooth, it need not be built up with amal- Round burs, of course, are most helpful in cavity toi-
gam, cement, or an orthodontic band; having to work let. The long-blade, endodontic spoon excavator is
through a hole only complicates the endodontic proce- ideal for debris removal (Figure 10-7). Irrigation with
dures. In addition, if the band comes off, the length of sodium hypochlorite is also an excellent measure for
tooth measurements is invalidated and must be cleansing the chamber and canals of persistent debris.
re-established. An adequate temporary filling can The chamber may finally be wiped out with cotton,
always be placed in the remaining pulp chamber. and a careful flush of air will eliminate the remaining
If enough tooth does not remain above the gingiva debris. However, air must never be aimed down the
to place a rubber dam clamp and seal against saliva, and canals. Emphysema of the oral tissues has been pro-
Figure 10-6 Carious involvement of the maxillary molar has Figure 10-7 Long-blade endodontic spoon excavator compared
destroyed most of the crown. Enough tooth structure remains to with standard Blacks spoon excavator. The long-blade instrument
adapt the rubber dam clamp. A wide-open cavity allows greater ease (left) is needed to reach the depths of molar preparations.
of operation. If the caries extends below the gingival level, gingivec-
tomy will expose solid tooth structure.
PLATE 2
Convenience Form
A. Obstructed access to mesial canals in a mandibular Walls are generally reduced with burs or long, thin
first molar. The overhanging roof of the pulp cham- diamond points (see B and C above) and with
ber misdirects the instrument mesially, with result- endodontic files, Gates-Glidden drills, or orifice
ing ledge formation in the canal. It is virtually openers. Burs are rarely used in the floor or imme-
impossible to see and difficult to locate mesial canal diate orifice area. In the event that a second canal is
orifices each time the instrument is introduced. suspected in the mesiobuccal root of the maxillary
B. Internal cavity preparation. Removing the roof molar, the cavity outline would be extended in both
completely from the pulp chamber will bring canal of these directions to broaden the search.
orifices into view and allow immediate access to Depending on the technique used to fill the canal,
each orifice. Using a round bur and working from the outline form may also be expanded somewhat
the inside out will accomplish this end. to accommodate pluggers used in obturation.
C. Final finish of the convenience form is completed F. The complete authority of the enlarging instru-
with a fissure bur, diamond point, or nonend-cut- ment is maintained when all intervening tooth
ting batt bur. The entire cavity slopes toward the structure is removed and the instrument is con-
mesial direction of approach, which greatly simpli- trolled by the clinicians fingers on the handle of
fies instrument placement. the instrument and the tip of the instrument is free
D. Unobstructed access to canal orifices. The mesial in the lumen of the canal.
wall has been sloped to mesial for the approach to G. Complete authority of enlarging instrument. If
the mandibular molar is from the mesial. The tip of the lateral wall of the cavity has not been suffi-
the instrument follows down the mesial wall at ciently extended and the pulpal horn portion of
each corner of the triangular preparation and liter- the orifice still remains in the wall, the orifice will
ally falls into orifices. After the position of each have the appearance of a tiny mouse hole. This
orifice has been determined, the mouth mirror lateral wall will then impinge on enlarging the
may be laid aside. instrument and will dictate the direction of the
The distal wall of preparation also slopes to the instrument tip. The operator will have lost control
mesial and is easily entered from the mesial of the instrument and the situation.
approach. H. By extending the lateral wall of the cavity, thus
E. Direct access to apical foramen. Extensive removal removing all intervening dentin from the orifice,
of coronal tooth structure is necessary to allow the mouse hole in the wall will be eliminated and
complete freedom of endodontic instruments in the orifice will appear completely in the floor. Now
the coronal cavity and direct access to the apical the enlarging instrument will stand free of the
canal. This is especially true when the root is severe- walls, and the operator will regain control of the
ly curved or leaves the chamber at an obtuse angle. instrument (see F above).
duced by a blast of air escaping out of the apex. In an authors, we have chosen the larger figures, that is, the
in vitro study, Eleazer and Eleazer found a direct rela- figures furthest from normal.924 We have also adapted
tion between the size of the apical foramen and the liberally from the important work by Dempster et al.
likelihood of expressing air into the periapical tissues. on the angulation of the teeth in the alveolar process.25
Addtional risks are incurred as air from these syringes In addition, new information on multiple canals has
is not sterile.8 Some dental schools do not allow the use been brought to light.
of the three-way air/water syringe once access into the
chamber has been achieved. Multiple and Extra Canals
As previously stated, toilet of the cavity makes up a Although it should come as no surprise, the high inci-
significant portion of the radicular preparations. dence of additional canals in molars, premolars, and
mandibular incisors is significant. Hess, as early as
DETAILED CORONAL CAVITY PREPARATION 1925, pointed out that 54% of his 513 maxillary molar
Descriptions and Caveats specimens had four canals.26 For years these facts were
With the basic principles of endodontic cavity prepara- generally ignored.
tion in mind, the student is urged to study the detailed At this juncture, however, one cannot help but be
plates that follow, each dealing with coronal prepara- struck by the magnitude of the numbers of additional
tion. Again, keep in mind the importance of the intra- versus traditional canals. For example, maxillary molars
coronal preparation to the ultimate radicular prepara- may have four canals rather than three canals as much
tion and filling. as 95% of the time. Using a No. 1 round bur and/or
For each group of teethfor example, maxillary ultrasonic instruments to remove secondary dentin
anterior teeth, mandibular premolar teeththere is a from the pulpal floor along the mesiobuccal-palatal leg
plate showing in detail the suggested cavity preparation of the molar triangle will uncover an additional 31% of
and operative technique applicable to that particular these orifices.27 An earlier study found these secondary
group of teeth. The technique plate is followed by canals 69% of the time in vitro but only 31% in vivo.23
plates of the individual teeth within the group. Four Another in vivo study found two canals in the
separate views of each tooth are presented: (1) the mesiobuccal roots of maxillary first molars 77% of the
facial-lingual view as seen in the radiograph; (2) the time, and, of these, 62% had two apical foramina.28
mesiodistal view, impossible to obtain radiographically Although a fourth root in maxillary molars is rare
but necessary to the three-dimensional mental image (0.4%),29,30 single-canal taurodontism (bull-tooth)
of the pulp anatomy; (3) a cross-sectional view at three was found in 11.3% of one patient cohort.31
levels; and (4) a view of the occlusal or lingual surface The incidence of accessory canals in the furcation of
with cavity outline form. maxillary molars, canals that extend all the way from
Detailed variations in preparation related to each the pulpal floor to the furcation area, is 48% in one
particular tooth, as well as information about tooth study32 and 68% in another.33 These accessory canals
length, root curvature, and canal anatomy variations, are only about twice the size of a dentinal tubule and so
are presented. These plates are followed by a plate of are rarely mistaken for a canal orifice even though they
errors commonly committed in the preparation of this are large enough to admit bacteria to the pulp from a
group of teeth. furcal periodontal lesion. In mandibular molars,
The mandibular incisorscentrals and laterals through-and-through furcal accessory canals are found
are so anatomically similar that they are confined to 56% of the time in one study32 and 48% in another.33
one plate. Mandibular molars also exhibit secondary root
The reader is reminded that the preparations illus- canals, over and above the traditional three. Although
trated here are minimal preparations, that the outline as many as five canals34 and as few as one and two
form is a direct reflection of the pulp anatomy. If the canals35,36 rarely occur in mandibular molars, four
pulp is expansive, the outline form will also be expan- canals are not unusual. Bjorndal and Skidmore report-
sive. Furthermore, the outline form may have to be ed this occurrence 29% of the time in a US cohort, a
greatly enlarged to accept heavier instruments or rigid second distal canal being the usual anomaly.23 The
filling materials. Chinese found four canals in 31.5% of their cases.37
Generally speaking, the length-of-tooth measure- Weine et al. however, reported that only 12.5% of their
ments are approximations. Nonetheless, they are help- second molar specimens had a second distal canal and
ful and should alert the dentist to what to expect as that only one had two separate apical foramina.35
normal. When there is a lack of agreement between Anomalies also occur in the mesial root.38
Premolar teeth are also prone to secondary canals. Ethnic variance may be one part of the equation.
Maxillary first premolars, which generally have two African Americans have more than twice as many
canals, have three canals 5 to 6% of the time.14,39 two-canal mandibular premolars (32.8% versus
Twenty-four percent of maxillary second premolars 13.7%) than do Caucasian patients: Four out of ten
have second root canals and occasionally three canals.15 black patients had at least one lower premolar with two
In Brazil, two canals were found 32.4% of the time and or more canals.42 In a southern Chinese population,
three canals in 0.3% of the cases.40 however, the roots of mandibular second molars are
Mandibular premolars are notorious for having fused 52% of the time and only have two canals, rather
extra canals26.5% in first premolars and 13.5% in than three, 55% of the time.36 The Chinese also have
second premolars.21 A US Army group reported canal two canal lower incisors 27% of the time, but only 1%
bifurcations as deep as 6 to 9 mm from the coronal ori- terminate in two foramina,43 compared to two forami-
fice 74% of the time in mandibular first premolars.22
na terminations 30% of the time in a US study.11 A
Almost one-third of all mandibular lateral incisors
Brazilian study reports two canals with two foramina in
have two canals with two foramina.11 A Turkish report
1.2% of mandibular canines.44
lists two newly defined canal configurations, one that
The incidence of taurodontism varies all over the
ends in three separate foramina.12
Every dentist who has done considerable root canal world. In Saudi Arabia, 43.2% of adult molars studied
therapy must ask, How many of these extra canals were taurodonts in 11.3% of the patient cohort.31 In
have I failed to find in the past? Also, there appears to Brazil, 11 cases of taurodontism in mandibular pre-
be a wide discrepancy between the figures quoted molars, a very rare occurrence, were described.45 The
above, which are based on laboratory studies, and those seminal studies of Pineda and Kuttler were done in
found under clinical conditions. Hartwell and Bellizi Mexico on extracted teeth, many presumably from a
found four canals in maxillary first molars only 18% of native cohort.14,18
the time in vivo (in comparison to the figure of 85% In any event, anomalous and multiple canals are a
found in vitro, cited above).41 In mandibular first worldwide problem, a fact that makes imperative a
molars, the reverse was true: they actually filled a careful search in every tooth for additional canals. Just
fourth canal 35% of the time, whereas 29% of extract- as important, the facts emphasize the necessity of
ed teeth had a fourth canal.41 choosing a method of preparation and filling that will
How may one account for the wide discrepancy ensure the obturations of these additional canals (see
between these figures of incidence of additional canals? Figure 10-5).
Plates 3 to 27
Folio of
CORONAL ENDODONTIC
CAVITY PREPARATIONS
Originally Illustrated by
VIRGINIA E. BROOKS
Modified by
PHYLLIS WOOD
PLATE 3
A. Entrance is always gained through the lingual sur- G. After the outline form is completed, the surgical-
face of all anterior teeth. Initial penetration is length bur is carefully passed into the canal.
made in the exact center of the lingual surface at Working from inside to outside, the lingual shoul-
the position marked X. A common error is to der is removed to give continuous, smooth-flowing
begin the cavity too far gingivally. preparation. Often a long, tapering diamond point
will better remove the lingual shoulder.
B. Initial entrance is prepared with a round-point
tapering fissure bur in an accelerated-speed con- H. Occasionally, a No. 1 or 2 round bur must be used
tra-angle handpiece with air coolant, operated at a laterally and incisally to eliminate pulpal horn
right angle to the long axis of the tooth. Only debris and bacteria. This also prevents future dis-
enamel is penetrated at this time. Do not force the coloration.
bur; allow it to cut its own way. I. Final preparation relates to the internal anatomy
C. Convenience extension toward the incisal contin- of the chamber and canal. In a young tooth with
ues the initial penetrating cavity preparation. a large pulp, the outline form reflects a large trian-
Maintain the point of the bur in the central cavity gular internal anatomyan extensive cavity that
and rotate the handpiece toward the incisal so that allows thorough cleansing of the chamber as well
the bur parallels the long axis of the tooth. Enamel as passage of large instruments and filling materi-
and dentin are beveled toward the incisal. als needed to prepare and fill a large canal. Cavity
Entrance into the pulp chamber should not be extension toward the incisal allows greater access to
made with an accelerated-speed instrument. Lack the midline of the canal.
of tactile sensation with these instruments pre- J. Cavity preparations in adult teeth, with the
cludes their use inside the tooth. chamber obturated with secondary dentin, are
D. The preliminary cavity outline is funneled and ovoid in shape. Preparation funnels down to the
fanned incisally with a fissure bur. Enamel has a orifice of the canal. The further the pulp has reced-
short bevel toward the incisal, and a nest is pre- ed, the more difficult it is to reach to this depth
pared in the dentin to receive the round bur to be with a round bur. Therefore, when the radiograph
used for penetration. reveals advanced pulpal recession, convenience
extension must be advanced further incisally to
E. A surgical-length No. 2 or 4 round bur in a allow the bur shaft and instruments to operate in
slow-speed contra-angle handpiece is used to pen- the central axis.
etrate the pulp chamber. If the pulp has greatly
receded, a No. 2 round bur is used for initial pene- K. Final preparation with the reamer in place. The
instrument shaft clears the incisal cavity margin
tration. Take advantage of convenience extension
and reduced lingual shoulder, allowing an unre-
toward the incisal to allow for the shaft of the pen-
strained approach to the apical third of the canal.
etrating bur, operated nearly parallel to the long
The instrument remains under the complete con-
axis of the tooth.
trol of the clinician. An optimal, round, tapered
F. Working from inside the chamber to outside, a cavity may be prepared in the apical third, tailored
round bur is used to remove the lingual and labial to the requirements of round, tapered filling mate-
walls of the pulp chamber. The resulting cavity is rials to follow. The remaining ovoid part of the
smooth, continuous, and flowing from cavity mar- canal is cleaned and shaped by circumferential fil-
gin to canal orifice. ing or Gates-Glidden drills.
PLATE 4
A. Lingual view of a recently calcified incisor with a labially and thus nearer the central axis. Incisal
large pulp. A radiograph will reveal extension allows better access for large instruments
1. extent of the pulp horns and filling materials used in the apical third canal.
2. mesiodistal width of the pulp
E. Lingual view of an adult incisor with extensive sec-
3. apical-distal curvature (8% of the time)
ondary dentin formation.
4. 2-degree mesial-axial inclination of the tooth
A radiograph will reveal
These factors seen in the radiograph are borne in
1. full pulpal recession
mind when preparation is begun.
2. apparently straight canal
B. Distal view of the same tooth demonstrating 3. 2-degree mesial-axial inclination of the tooth
details not apparent in the radiograph:
1. presence of a lingual shoulder at the point F. Distal view of the same tooth demonstrating
where the chamber and canal join details not apparent in the radiograph:
2. broad labiolingual extent of the pulp 1. narrow labiolingual width of pulp
3. 29-degree lingual-axial angulation of the tooth 2. reduced size of the lingual shoulder
3. apical-labial curvature (9% of the time)
The operator must recognize that 4. 29-degree lingual-axial angulation of the tooth
a. the lingual shoulder must be removed with a
tapered diamond point to allow better access The operator must recognize that
to the canal. a. a small canal orifice is difficult to find.
b. these unseen factors affect the size, shape, b. apical-labial curvature, not usually seen radi-
and inclination of final preparation. ographically, can be determined by explo-
ration with a fine curved file and mesially ori-
C. Cross-sections at three levels: 1, cervical; 2, mid- ented radiographs.
root; and 3, apical third: c. axial inclination of the root calls for careful
1. Cervical level: the pulp is enormous in a young orientation and alignment of the bur to pre-
tooth, wider in the mesiodistal dimension. vent gouging.
Dbridement in this area is accomplished by
extensive perimeter filing. G. Cross-sections at three levels: 1, cervical; 2, mid-
2. Midroot level: the canal continues ovoid and root; and 3, apical third:
requires perimeter filing and multiple point 1. Cervical level: the canal, only slightly ovoid,
filling. becomes progressively more round.
3. Apical third level: the canal, generally round in 2. Midroot level: the canal varies from slightly
shape, is enlarged by reshaping the cavity into ovoid to round.
a round tapered preparation. Preparation ter- 3. Apical third level: the canal is generally round
minates at the cementodentinal junction, 0.5 in the older patient.
to 1.0 mm from the radiographic apex. An H. Ovoid, funnel-shaped coronal preparation pro-
unusually large apical third canal is more ovoid vides adequate access to the root canal. The pulp
in shape, must be prepared with perimeter fil- chamber, obturated by secondary dentin, need not
ing rather than reaming, and must be obturat- be extended for coronal dbridement. Adult cav-
ed with multiple points or warm gutta-percha. ity preparation is narrow in the mesiodistal width
D. Large, triangular, funnel-shaped coronal prepara- but is almost as extensive in the incisogingival
tion is necessary to adequately dbride the cham- direction as preparation in a young tooth. This
ber of all pulp remnants. (The pulp is ghosted in beveled incisal extension carries preparation near-
the background.) Note the beveled extension er the central axis, allowing better access to the
toward the incisal that will carry the preparation curved apical third.
PLATE 5
A. Lingual view of a recently calcified incisor with a E. Lingual view of an adult incisor with extensive sec-
large pulp. A radiograph will reveal ondary dentin formation.
1. extent of the pulp horns A radiograph will reveal
2. mesiodistal width of the pulp 1. full pulp recession
3. apical-distal curvature (53% of the time) 2. severe apical curve to the distal
4. 16-degree mesial-axial inclination of the tooth 3. 16-degree mesial-axial inclination of the tooth
Factors seen in the radiograph are borne in mind
F. Distal view of the same tooth demonstrating
when preparation is begun.
details not apparent in the radiograph
B. Distal view of the same tooth demonstrating 1. narrow labiolingual width of the pulp
details not apparent in the radiograph: 2. reduced size of the lingual shoulder
1. presence of a lingual shoulder at the point 3. apical-lingual curvature (4% of the time)
where the chamber and canal join 4. 29-degree lingual-axial angulation of the tooth
2. broad labiolingual extent of the pulp
The operator must recognize that
3. 29-degree lingual-axial angulation of tooth
a. a small canal orifice is difficult to find.
The operator must recognize that b. apical-lingual curvature, not usually seen radi-
a. the lingual shoulder must be removed with a ographically, can be determined by explo-
tapered diamond point to allow better access ration with a fine curved file and mesially ori-
to the canal. ented radiographs.
b. these unseen factors will affect the size, c. axial inclination of the root calls for careful
shape, and inclination of final preparation. orientation and alignment of the bur to pre-
vent labial gouging. A corkscrew curve, to
C. Cross-sections at three levels: 1, cervical; 2, mid-
the distal and lingual, complicates preparation
root; and 3, apical third:
of the apical third of the canal.
1. Cervical level: the pulp is large in a young
tooth and wider in the labiolingual dimension. G. Cross-sections at three levels: 1, cervical; 2, mid-
Dbridement in this area is accomplished by root; and 3, apical third:
extensive perimeter filing. 1. Cervical level: the canal is only slightly ovoid
2. Midroot level: the canal continues ovoid and and becomes progressively rounder.
requires additional filing to straighten the grad- 2. Midroot level: the canal varies from slightly
ual curve. Multiple point filling is necessary. ovoid to round.
3. Apical third level: the canal, generally round 3. Apical third level: the canal is generally round
and gradually curved, is enlarged by filing to a in the older patient.
straightened trajectory. Preparation is com- A curved canal is enlarged by alternate reaming
pleted by shaping the cavity into a round, and filing. Ovoid preparation will require multiple
tapered preparation. Preparation terminates at point filling.
the cementodentinal junction, 0.5 to 1.0 mm
H. Ovoid, funnel-shaped coronal preparation should
from the radiographic apex.
be only slightly skewed toward the mesial to pres-
D. Large, triangular, funnel-shaped coronal prepara- ent better access to the apical-distal. It is not neces-
tion is necessary to adequately dbride the chamber sary to extend preparation for coronal dbride-
of all pulpal remnants. (The pulp is ghosted in the ment, but an extensive bevel is necessary toward
background.) Note the beveled extension toward the the incisal to carry preparation nearer the central
incisal, which will carry the preparation labially and axis, allowing better access to the apical third.
thus nearer the central axis. Incisal extension allows
better access to the apical third of the canal.
PLATE 6
Maxillary Canine
Pulp Anatomy and Coronal Preparation
A. Lingual view of a recently calcified canine with a in the background.) Note the long, beveled exten-
large pulp. A radiograph will reveal sion toward the incisal, which will carry the prepa-
1. coronal extent of the pulp ration labially and thus nearer the central axis.
2. narrow mesiodistal width of the pulp Incisal extension allows better access for large
3. apical-distal curvature (32% of the time) instruments and filling materials used in the apical
4. 6-degree distal-axial inclination of the tooth third of the canal.
These factors, seen in the radiograph, are borne in
E. Lingual view of an adult canine with extensive sec-
mind when preparation is begun, particularly the
ondary dentin formation. A radiograph will reveal
severe apical curve.
1. full pulp recession
B. Distal view of the same tooth demonstrating 2. straight canal (39% of the time)
details not apparent in the radiograph: 3. 6-degree distal-axial inclination of tooth
1. huge ovoid pulp, larger labiolingually than the
F. Distal view of the same tooth demonstrating
radiograph would indicate
details not apparent in the radiograph:
2. presence of a labial shoulder just below the
1. narrow labiolingual width of the pulp
cervical
2. apical labial curvature (13% of the time)
3. narrow canal in the apical third of the root
3. 21-degree lingual-axial angulation of the tooth
4. 21-degree lingual-axial angulation of the tooth
These unseen factors will affect the size, shape, The operator should recognize that
and inclination of the final preparation. a. a small canal orifice is difficult to find.
b. apical labial curvature, not seen radiographi-
C. Cross-section is at three levels: 1, cervical; 2, mid-
cally, can be determined only by exploration
root; and 3, apical third:
with a fine curved file and mesially oriented
1. Cervical level: the pulp is enormous in a young
radiographs.
tooth, much wider in the labiolingual direc-
c. distal-lingual axial inclination of the root calls
tion. Dbridement in this area is accomplished
for careful orientation and alignment of the
with a long, tapered diamond point and exten-
bur to prevent gouging.
sive perimeter filing.
d. apical foramen toward the labial is a problem.
2. Midroot level: the canal continues ovoid in
shape and requires perimeter filing and multi- G. Cross-sections at three levels: 1, cervical; 2, mid-
ple point filling. root; and 3, apical third:
3. Apical third level: the straight canal (39% of 1. Cervical level: the canal is slightly ovoid.
time), generally round in shape, is prepared by 2. Midroot level: the canal is smaller but remains
shaping the cavity into round tapered prepara- ovoid.
tion. Preparation should terminate at the cemen- 3. Apical third level: the canal becomes progres-
todentinal junction, 0.5 to 1.0 mm from the sively rounder.
radiographic apex. If unusually large or curved,
H. Extensive, ovoid, funnel-shaped preparation must
the apical canal requires perimeter filing and
be nearly as large as for a young tooth. A beveled
multiple point or warm gutta-percha filling.
incisal extension carries preparation nearer the
D. Extensive, ovoid, funnel-shaped coronal prepara- central axis, allowing better access to the curved
tion is necessary to adequately dbride the cham- apical third. Discovery by exploration of an apical-
ber of all pulpal remnants. (The pulp is ghosted labial curve calls for even greater incisal extension.
Maxillary Canines
PLATE 7
A. PERFORATION at the labiocervical caused by fail- E. DISCOLORATION of the crown caused by failure
ure to complete convenience extension toward the to remove pulp debris. The access cavity is too far
incisal, prior to the entrance of the shaft of the bur. to the gingival with no incisal extension.
B. GOUGING of the labial wall caused by failure to F. LEDGE formation at the apical-distal curve caused
recognize the 29-degree lingual-axial angulation of by using an uncurved instrument too large for the
the tooth. canal. The cavity is adequate.
C. GOUGING of the distal wall caused by failure to G. PERFORATION at the apical-distal curve caused
recognize the 16-degree mesial-axial inclination of by using too large an instrument through an inad-
the tooth. equate preparation placed too far gingivally.
D. PEAR-SHAPED PREPARATION of the apical canal H. LEDGE formation at the apical-labial curve caused
caused by failure to complete convenience exten- by failure to complete the convenience extension.
sions. The shaft of the instrument rides on the cav- The shaft of the instrument rides on the cavity
ity margin and lingual shoulder. Inadequate margin and shoulder.
dbridement and obturation ensure failure.
PLATE 8
A. Entrance is always gained through the lingual sur- from inside to outside, the lingual shoulder is
face of all anterior teeth. Initial penetration is made removed with a long, fine, tapered diamond point to
in the exact center of the lingual surface at the posi- give a continuous, smooth-flowing preparation.
tion marked X. A common error is to begin too
H. Occasionally, a No. 1 round bur must be used lat-
far gingivally.
erally and incisally in the cavity to eliminate pulpal
B. The initial entrance cavity is prepared with a 701 U horn debris and bacteria. This also prevents future
tapering fissure bur in an accelerated-speed con- discoloration.
tra-angle handpiece with air coolant, operated at a
I. Final preparation related to the internal anatomy
right angle to the long axis of the tooth. Only
of the chamber and canal. In a young tooth with
enamel is penetrated at this time. Do not force the
a large pulp, the outline form reflects triangular
bur; allow it to cut its own way.
internal anatomyan extensive cavity that allows
C. Convenience extension toward the incisal continues thorough cleansing of the chamber as well as pas-
initial penetrating cavity. Maintain the point of the sage of large instruments and filling materials
bur in the central cavity and rotate the handpiece needed to prepare and fill the large canal. Note
toward the incisal so that the bur parallels the long extension toward the incisal to allow better access
axis of the tooth. Enamel and dentin are beveled to the central axis.
toward the incisal. Entrance into the pulp chamber
J. Cavity preparations in an adult tooth with the
should not be made with an accelerated-speed
chamber obliterated with secondary dentin are
instrument. Lack of tactile sensation with these ovoid. Preparation funnels down to the orifice of
instruments precludes their use inside the tooth. the canal. The further the pulp has receded, the
D. The preliminary cavity outline is funneled and more difficult it is to reach to this depth with a
fanned incisally with a fissure bur. The enamel has round bur. Therefore, when a radiograph reveals
a short bevel toward the incisal, and a nest is pre- advanced pulpal recession, convenience exten-
pared in the dentin to receive the round bur to be sion must be advanced further incisally to allow
used for penetration. the bur shaft to operate in the central axis. The
incisal edge may even be invaded and later
E. A surgical-length No. 2 round bur in a slow-speed
restored by composites.
contra-angle handpiece is used to penetrate into the
pulp chamber. If the pulp has greatly receded, the K. Final preparation showing the reamer in place.
No. 2 round bur is used for initial penetration. Take The instrument shaft clears the incisal cavity
advantage of convenience extension toward the margin and reduced lingual shoulder, allowing an
incisal to allow for the shaft of the penetrating bur, unrestrained approach to the apical third of the
operated nearly parallel to the long axis of the tooth. canal. The instruments remain under the com-
plete control of the clinician. Great care must be
F. Working from inside the chamber to the outside, a
taken to explore for additional canals, particular-
round bur is used to remove the lingual and labial
ly to the lingual of the pulp chamber. An optimal
walls of the pulp chamber. The resulting cavity is
round, tapered cavity may be prepared in the api-
smooth, continuous, and flowing from cavity mar-
cal third, tailored to requirements of round,
gin to canal orifice.
tapered filling materials to follow. The remaining
G. After the outline form is completed, a surgical-length ovoid part of the canal is cleaned and shaped by
bur is carefully passed down into the canal. Working extensive filing.
PLATE 9
A. Lingual view of a recently calcified incisor with a E. Lingual view of an adult incisor with extensive sec-
large pulp. A radiograph will reveal ondary dentin formation.
1. extent of the pulp horns A radiograph will reveal:
2. mesiodistal width of the pulp 1. full pulp recession
3. slight apical-distal curvature of the canal (23% 2. an apparently straight canal
of the time) 3. mesial-axial inclination of the tooth (central
4. mesial-axial inclination of the tooth (central incisor 2 degrees, lateral incisor 17 degrees).
incisor 2 degrees, lateral incisor 17 degrees).
F. Distal view of the same tooth demonstrating
These factors, seen in the radiograph, are borne in
details not apparent in the radiograph:
mind when preparation is begun.
1. labiolingual width of the pulp
B. Distal view of the same tooth demonstrating 2. reduced size of the lingual shoulder
details not apparent in the radiograph: 3. unsuspected presence of bifurcation of pulp
1. presence of a lingual shoulder at the point into the labial and lingual canals nearly 30%
where the chamber and canal join of the time
2. broad labiolingual extent of the pulp 4. 20-degree lingual-axial angulation of the tooth
3. 20-degree lingual-axial angulation of the tooth
The operator must recognize that
The operator must recognize that
a. smaller canal orifices are more difficult to find.
a. the lingual shoulder must be removed with a
b. labial and lingual canals are discovered by
fine, tapered diamond point to allow better
exploration with a fine curved file to both labi-
access to the canal.
al and lingual.
b. these unseen factors affect the size, shape,
c. axial inclination of the root calls for careful
and inclination of the final preparation.
orientation and alignment of the bur to pre-
C. Cross-sections at three levels: 1, cervical; 2, mid- vent gouging.
root; 3, apical third:
1. Cervical level: the pulp is enormous in a young G. Cross-sections at three levels: 1, cervical; 2, mid-
tooth, wider in the labiolingual dimension. root; and 3, apical third:
Dbridement in this area is accomplished by 1. Cervical level: the canal is only slightly ovoid.
extensive perimeter filing. 2. Midroot level: the two canals are essentially
2. Midroot level: the canal continues ovoid and round.
requires perimeter filing and multiple point 3. Apical third level: the canals are round and
filling. curve toward the labial.
3. Apical third level: the canal, generally round in It is important that all mandibular anterior teeth
shape, is enlarged by shaping the cavity into a be explored to both labial and lingual for the pos-
round, tapered preparation. Preparation ter- sibility of two canals.
minates at the cementodentinal junction, 0.5 H. Ovoid, funnel-shaped coronal preparation provides
to 1.0 mm from the radiographic apex. adequate access to the root canal. An adult cavity is
D. Large, triangular, funnel-shaped coronal prepara- narrow in the mesiodistal width but is as extensive in
tion is necessary to adequately dbride the chamber the incisogingival direction as preparation in a
of all pulp remnants. (The pulp is ghosted in the young tooth. This beveled incisal extension carries
background.) Note the beveled extension toward the preparation nearer to the central axis. The incisal
incisal, which will carry the preparation labially and edge may even be invaded. This will allow better
thus nearer the central axis. Incisal extension allows access to both canals and the curved apical third.
better access for instruments and filling materials Ideal lingual extension and better access will often
used in the apical third of the canal. lead to discovery of the second canal.
Average Length 21.5 mm 22.4 mm One canal 70.1% 56.9% Straight 60%
One foramen
Maximum Length 23.4 mm 24.6 mm Two canals 23.4% 14.7% Distal Curve 23%
One foramen
Minimum Length 19.6 mm 20.2 mm Two canals 6.5% 29.4% Mesial Curve 0%
Two foramens
Range 3.8 mm 4.4 mm Lateral canals 5.2% 13.9% *Labial Curve 13%
*Lingual Curve 0%
*Not apparent in radiograph
PLATE 10
Mandibular Canine
Pulp Anatomy and Coronal Preparation
A. Lingual view of a recently calcified canine with a the background.) Note the beveled extension
large pulp. A radiograph will reveal toward the incisal, which will carry the preparation
1. coronal extent of the pulp labially and thus nearer the central axis. Incisal
2. narrow mesiodistal width of the pulp extension allows better access for large instruments
3. apical-distal curvature (20% of the time) and filling materials used in the apical third canal.
4. 13-degree mesial-axial inclination of tooth
E. Lingual view of an adult canine with extensive sec-
These factors, seen in the radiograph, are borne in
ondary dentin formation. A radiograph will reveal
mind when preparation is begun.
1. full pulp recession
B. Distal view of the same tooth demonstrating 2. slight distal curve of the canal (20% of the
details not apparent in the radiograph: time)
1. broad labiolingual extent of the pulp 3. 13-degree mesial-axial inclination of the tooth
2. narrow canal in the apical third of the root
3. apical-labial curvature (7% of time) F. Distal view of the same tooth demonstrating
4. 15-degree lingual-axial angulation of the tooth details not apparent in the radiograph:
These unseen factors affect the size, shape, and 1. labiolingual width of the pulp
inclination of the final preparation. 2. 15-degree lingual-axial angulation of the tooth
The operator must recognize that
C. Cross-sections at three levels: 1, cervical; 2, mid- a. a small canal orifice, positioned well to the
root; and 3, apical third: labial, is difficult to find.
1. Cervical level: the pulp is enormous in a young b. lingual-axial angulation calls for careful orien-
tooth, wider in the labiolingual direction. tation of the bur to prevent gouging.
Dbridement in this area is accomplished with c. apical-labial curvature (7% of the time).
extensive perimeter filing.
2. Midroot level: the canal continues ovoid and G. Cross-sections at three levels: 1, cervical; 2, mid-
requires perimeter filing and multiple root; and 3, apical third:
gutta-percha point filling. 1. Cervical level: the canal is slightly ovoid.
3. Apical third level: the canal, generally round, is 2. Mid-root level: the canal is smaller but remains
enlarged by filing to reduce the curve to a rela- ovoid.
tively straight canal. This canal is then complet- 3. Apical third level: the canal becomes progres-
ed by shaping action into round, tapered prepa- sively rounder.
ration. Preparation terminates at the cemento- The canal is enlarged by filing and is filled.
dentinal junction, 0.5 to 1.0 mm from the radi- H. Extensive ovoid, funnel-shaped preparations must
ograph apex. If unusually large or ovoid, the be as large as preparation for a young tooth. The
apical canal requires perimeter filing. cavity should be extended incisogingivally for
D. Extensive ovoid, funnel-shaped coronal prepara- room to find the orifice and enlarge the apical third
tion is necessary to adequately dbride the cham- without interference. An apical-labial curve would
ber of all pulp remnants. (The pulp is ghosted in call for increased extension incisally.
Mandibular Canines
PLATE 11
A. GOUGING at the labiocervical caused by failure to D. FAILURE to explore, dbride, or fill the second
complete convenience extension toward the incisal canal caused by inadequate incisogingival exten-
prior to entrance of the shaft of the bur. sion of the access cavity.
B. GOUGING of the labial wall caused by failure to E. DISCOLORATION of the crown caused by failure
recognize the 20-degree lingual-axial angulation of to remove pulp debris. The access cavity is too far
the tooth. to the gingival with no incisal extension.
C. GOUGING of the distal wall caused by failure to F. LEDGE formation caused by complete loss of con-
recognize the 17-degree mesial-axial angulation of trol of the instrument passing through the access
the tooth. cavity prepared in proximal restoration.
PLATE 12
A. Entrance is always gained through the occlusal sur- Tension of the explorer shaft against the walls of
face of all posterior teeth. Initial penetration is preparation will indicate the amount and direction
made parallel to the long axis of the tooth in the of extension necessary.
exact center of the central groove of the maxillary
D. Working from inside the pulp chamber to outside,
premolars. The 701 U tapering fissure bur in an
a round bur is used at low speed to extend the cav-
accelerated-speed contra-angle handpiece is ideal
ity buccolingually by removing the roof of the pulp
for penetrating gold casting or virgin enamel sur-
chamber.
face to the depth of the dentin. Amalgam fillings
are opened with a No. 4 round bur in a slow-speed E. Buccolingual extension and finish of cavity walls
contra-angle handpiece. are completed with a 701 U fissure bur at acceler-
ated speed.
B. A regular-length No. 2 or 4 round bur is used to
open into the pulp chamber. The bur will be felt to F. Final preparation should provide unobstructed
drop when the pulp chamber is reached. If the access to canal orifices. Cavity walls should not
chamber is well calcified and the drop is not felt, impede complete authority over enlarging instru-
vertical penetration is made until the contra-angle ments.
handpiece rests against the occlusal surface. This G. Outline form of final preparation will be identical
depth is approximately 9 mm, the position of the for both newly erupted and adult teeth.
floor of the pulp chamber that lies at the cervical Buccolingual ovoid preparation reflects the anato-
level. In removing the bur, the orifice is widened my of the pulp chamber and the position of the
buccolingually to twice the width of the bur to buccal and lingual canal orifices. The cavity must
allow room for exploration for canal orifices. If a be extensive enough to allow for instruments and
surgical-length bur is used, care must be exercised filling materials needed to enlarge and fill canals.
not to perforate the furca. Further exploration at this time is imperative. It
C. An endodontic explorer is used to locate orifices to may reveal the orifice to an additional canal, a sec-
the buccal and lingual canals in the first premolar ond canal in the second premolar, or a third canal
or the central canal in the second premolar. in the first premolar.
PLATE 13
A. Buccal view of a recently calcified first premolar E. Buccal view of an adult first premolar with exten-
with a large pulp. sive secondary dentin formation. A radiograph will
A radiograph, if exposed slightly from the mesial, reveal
will reveal 1. full pulp recession and thread-like appearance
1. mesiodistal width of the pulp of the pulp
2. presence of two pulp canals 2. radiographic appearance of only one canal
3. apparently straight canals 3. 10-degree distal-axial inclination of the tooth
4. 10-degree distal-axial inclination of the tooth Owing to misalignment of the bur, perforation of
These factors, seen in the radiograph, are borne in the mesiocervical, at the point of mesial indenta-
mind when preparation is begun. One should tion, may occur.
always expect two and occasionally three canals.
F. Mesial view of the same tooth demonstrating
B. Mesial view of the same tooth demonstrating details not apparent in the radiograph:
details not apparent in the radiograph: 1. pulp recession and a greatly flattened pulp
1. height of the pulp horns chamber
2. broad buccolingual dimension of the pulp 2. buccolingual width revealing the pulp to be
3. two widespread and separate roots, each with a ribbon shaped rather than thread-like
single straight canal 3. single root with parallel canals and a single
4. 6-degree buccal-axial angulation of the tooth apical foramen
These unseen factors will affect the size and shape 4. 6-degree buccal-axial angulation of the tooth
of the final preparation. Pulp horns in the roof of
The operator must recognize that
the pulp chamber are not to be confused with true
a. small canal orifices are found well to the buccal
canal orifices in the cavity floor. Verticality of the
and lingual and are difficult to locate.
tooth simplifies orientation and bur alignment.
b. the direction of each canal is determined only
C. Cross-sections at three levels: 1, cervical; 2, mid- by exploration with a fine curved instrument.
root; and 3, apical third: c. a single apical foramen cannot be determined;
1. Cervical level: the pulp is enormous in a therefore, two canals must be managed as two
young tooth, very wide in the buccolingual separate canals.
direction. Dbridement of the chamber is d. virtually always there will be two and occa-
completed in coronal cavity preparation with sionally three canals.
a round bur. Canal orifices are found well to
G. Cross-sections at three levels: 1, cervical; 2, mid-
the buccal and lingual.
root; and 3, apical third:
2. Midroot level: the canals are only lightly ovoid
1. Cervical level: the chamber is very narrow
and may be enlarged to a round, tapered cavity.
ovoid, and canal orifices are at the buccal and
3. Apical third level: the canals are round and are
lingual termination of the floor.
shaped into round, tapered preparations.
2. Midroot level: the canals are round.
Preparations terminate at the cementodenti-
3. Apical third level: the canals are round.
nal junction, 0.5 to 1.0 mm from the radio-
graphic apex. H. Ovoid coronal preparation must be more extensive
in the buccolingual direction because of parallel
D. Ovoid coronal preparation need not be as long
canals. More extensive preparation allows instru-
buccolingually as the pulp chamber. However, the
mentation without interference.
outline form must be large enough to provide two
filling points at same time. Buccal and lingual walls
smoothly flow to orifices.
Curvature of Roots
PLATE 14
A. Buccal view of a recently calcified second premolar 1. pulp recession and the thread-like appear-
with a large pulp. A radiograph will reveal ance of the pulp
1. narrow mesiodistal width of the pulp 2. roentgen appearance of two roots (2% of the
2. apical-distal curvature (34% of the time) time)
3. 19-degree distal-axial inclination of the tooth 3. bayonet curve of the roots (20% of the time)
These factors, seen in the radiograph, are borne in 4. 19-degree distal-axial inclination of the tooth
mind when preparation is begun. F. Mesial view of the same tooth demonstrating
B. Mesial view of the same tooth demonstrating details not apparent in the radiograph:
details not apparent in the radiograph: 1. buccolingual width revealing the coronal pulp
1. broad buccolingual width revealing the pulp to to be ribbon shaped rather than thread-like
be ribbon shaped 2. high bifurcation and two separate apical third
2. single root with a large single canal roots
3. 9-degree lingual-axial angulation of the tooth
3. 9-degree lingual-axial angulation of the tooth
The operator must recognize that
The pulp is shown to be a broad ribbon rather
a. small canal orifices are deeply placed in the
than a thread as it appears from radiograph.
root and will be difficult to locate.
These unseen factors affect the size, shape, and b. the direction of each canal is determined by
inclination of the final preparation. exploration with a fine curved file carried down
C. Cross-sections at three levels: 1, cervical; 2, mid- the wall until the orifice is engaged. Then, by
root; and 3, apical third: half-rotation, the file is turned to match the first
1. Cervical level: the pulp is enormous in a young curve of the canal, followed by penetration until
tooth, very wide in the buccolingual direction. the tip again catches on the curved wall. A sec-
Dbridement of the chamber is completed ond half-turn and further penetration will carry
during coronal cavity preparation with a the tip of the instrument to within 0.5 to
round bur. The canal orifice is directly in the 1.0 mm of the radiographic apex. Retraction
will remove dentin at both curves.
center of the tooth.
2. Midroot level: the canal remains ovoid in G. Cross-sections at three levels: 1, cervical; 2, mid-
shape and requires perimeter filing. root; and 3, apical third:
3. Apical third level: the canal, round in shape, is 1. Cervical level: the chamber, very narrow ovoid,
filed and then shaped into a round, tapered extends deeply into the root.
preparation. Preparation terminates at the 2. Midroot level: the bayonet curve and round
cementodentinal junction, 0.5 to 1.0 mm from canal orifices are apparent.
the radiographic apex. 3. Apical third level: the canals are round. The
severe curve at the bayonet is reduced by fil-
D. Ovoid preparation allows dbridement of the ing action into a gradual curve.
entire pulp chamber and funnels down to the
ovoid midcanal. H. An ovoid coronal cavity is prepared well to the
mesial of the occlusal surface, with a depth of pen-
E. Buccal view of an adult second premolar with exten- etration skewed toward the bayonet curvature.
sive secondary dentin formation. A radiograph, if Skewing the cavity allows an unrestrained
exposed slightly from the mesial, will reveal approach to the first curve.
PLATE 15
A. UNDEREXTENDED preparation exposing only D. FAULTY ALIGNMENT of the access cavity through
pulp horns. Control of enlarging instruments is full veneer restoration placed to straighten the
abdicated to cavity walls. The white color of the crown of a rotated tooth. Careful examination of the
roof of the chamber is a clue to a shallow cavity. radiograph would reveal the rotated body of the tooth.
B. OVEREXTENDED preparation from a fruitless E. BROKEN INSTRUMENT twisted off in a
search for a receded pulp. The enamel walls have cross-over canal. This frequent occurrence may
been completely undermined. Gouging relates to be obviated by extending the internal preparation
failure to refer to the radiograph, which clearly to straighten the canals (dotted line).
indicates pulp recession. F. FAILURE to explore, dbride, and obturate the
C. PERFORATION at the mesiocervical indentation. third canal of the maxillary first premolar (6% of
Failure to observe the distal-axial inclination of the the time).
tooth led to bypassing receded pulp and perfora- G. FAILURE to explore, dbride, and obturate the sec-
tion. The maxillary first premolar is one of the ond canal of the maxillary second premolar (24%
most commonly perforated teeth. of the time).
PLATE 16
A. Entrance is always gained through the occlusal sur- D. Working from inside the pulp chamber to outside,
face of all posterior teeth. Initial penetration is a regular-length No. 2 or 4 round bur is used to
made in the exact center of the central groove of extend the cavity buccolingually by removing the
mandibular premolars. The bur is directed parallel roof of the pulp chamber.
to the long axis of the tooth. The 702 U taper fis-
sure bur in an accelerated-speed contra-angle E. Buccolingual extension and finish of cavity walls
handpiece is ideal for perforating gold casting or are completed with a 702 U fissure bur at acceler-
virgin enamel surface to the depth of the dentin. ated speed.
Amalgam fillings are penetrated with a round bur
F. Final ovoid preparation is a tapered funnel from
in a high-speed contra-angle handpiece.
the occlusal to the canal, providing unobstructed
B. A regular-length No. 4 round bur is used to open access to the canal. No overhanging tooth structure
vertically into the pulp chamber. The bur will be should impede complete authority over enlarging
felt to drop when the pulp chamber is reached. If instruments.
the chamber is well calcified, initial penetration is
continued until the contra-angle handpiece rests G. Buccolingual ovoid outline form reflects the anato-
against the occlusal surface. This depth of 9 mm is my of the pulp chamber and position of the cen-
the usual position of the canal orifice that lies at the trally located canal. The cavity is extensive enough
cervical level. In removing the bur, the occlusal to allow for instruments and filling the materials
opening is widened buccolingually to twice the needed to enlarge and fill canals. Further explo-
width of the bur to allow room for exploration. ration at this time may reveal the orifice to an
C. An endodontic explorer is used to locate the cen- additional canal, especially a second canal in the
tral canal. Tension of the explorer against the walls first premolar. The outline form of the final prepa-
of preparation will indicate the amount and direc- ration will be identical for both newly erupted and
tion of extension necessary. adult teeth.
PLATE 17
A. Buccal view of a recently calcified first premolar allow passage of instruments used to enlarge and
with a large pulp. A radiograph, if exposed slightly fill the canal space.
from the mesial, will reveal:
E. Buccal view of an adult first premolar with exten-
1. narrow mesiodistal width of the pulp
sive secondary dentin formation. A radiograph will
2. presence of one pulp canal
reveal
3. relatively straight canal
1. pulp recession and thread-like appearance of
4. 14-degree distal-axial inclination of the root
the pulp
All of these factors, seen in radiograph, are borne
2. radiographic appearance of only one canal
in mind when preparation is begun.
3. 14-degree distal-axial inclination of the root
B. Mesial view of the same tooth demonstrating
F. Mesial view of the same tooth demonstrating
details not apparent from the radiograph:
details not apparent in the radiograph:
1. height of the pulp horn
1. buccolingual ribbon-shaped coronal pulp
2. broad buccolingual extent of the pulp
2. single-root, bifurcated canal at the midroot
3. apical-buccal curvature (2% of the time)
level and a single apical foramen
4. 10-degree lingual-axial angulation of the root
3. 10-degree lingual-axial angulation of the root
These unseen factors will affect the size, shape,
and inclination of the final preparation. Severe api- The operator must recognize that
cal curvature can be detected only by exploration a. small orifices are difficult to locate.
with a fine curved file. Near-verticality of the tooth b. the presence of a bifurcated canal is determined
simplifies orientation and bur alignment. only by exploration with a fine curved file.
c. a single apical foramen can be determined by
C. Cross-sections at three levels: 1, cervical; 2, mid-
placing instruments in both canals at the same
root; and 3, apical third:
time. The instruments will be heard and felt to
1. Cervical level: the pulp is enormous in a young
grate against each other.
tooth, very wide in the buccolingual dimen-
sion. Dbridement of the ovoid chamber is G. Cross-sections at three levels: 1, cervical; 2, mid-
completed during coronal cavity preparation root; and 3, apical third:
with a round bur. 1. Cervical level: the chamber is very narrow
2. Midroot level: the canal continues ovoid and ovoid.
requires perimeter filing. 2. Midroot level: the two branches of the canal
3. Apical third level: the canal, generally round in are round.
shape, is enlarged by shaping into a round, 3. Apical third level: the canal is round.
tapered preparation. Preparation terminates at Divisions of the canal are enlarged by filing. The
the cementodentinal junction, 0.5 to 1.0 mm buccal canal would be filled to the apex and the lin-
from the radiographic apex. gual canal to the point where the canals rejoin.
D. Ovoid coronal preparation allows dbridement of H. Ovoid funnel-shaped coronal preparation must be
the entire pulp chamber, funnels down to the ovoid extensive enough buccolingually to allow for
midcanal, and is large enough buccolingually to enlarging and filling both canals.
PLATE 18
A. Buccal view of a recently calcified second premolar buccolingually to allow enlarging and filling of
with a large pulp. A radiograph will reveal both canals.
1. mesiodistal width of the pulp
E. Buccal view of an adult second premolar with
2. apical-distal curvature (40% of the time)
extensive secondary dentin formation. A radi-
3. 10-degree distal-axial inclination of the root
ograph, if exposed slightly from the mesial, will
These factors, seen in the radiograph, are borne in
reveal
mind when preparation is begun.
1. pulp recession and thread-like appearance of
B. Mesial view of the same tooth demonstrating the pulp
details not apparent in the radiograph: 2. sweeping distal curve of the apical third of the
1. broad buccolingual ribbon-shaped coronal root of the tooth (40% of the time)
pulp 3. 10-degree distal-axial angulation of the root
2. single root with pulpal bifurcation in the apical
F. Mesial view of the same tooth demonstrating
third
details not apparent in the radiograph:
3. 34-degree buccal-axial angulation of the root
1. buccolingual ribbon-shaped pulp
These unseen factors affect the size, shape, and
2. minus 34-degree buccal-axial angulation of the
inclination of the final preparation. Apical third
root
bifurcation, unseen in the radiograph, emphasizes
the necessity of careful canal exploration. The operator should recognize that
a. a small canal orifice will be difficult to locate.
C. Cross-sections at three levels: 1, cervical; 2, mid-
b. the direction of the canal is best explored with
root; and 3, apical third:
a fine curved file that is carried to within 0.5 to
1. Cervical level: the pulp is large in a young
1.0 mm of the radiographic apex. Retraction
tooth, very wide in the buccolingual dimen-
will then remove dentin at the curve.
sion. Dbridement of the chamber is complet-
ed during coronal cavity preparation with a G. Cross-sections at three levels: 1, cervical; 2, mid-
round bur. root; and 3, apical third:
2. Midroot level: the canal continues to be long 1. Cervical level: the chamber is very narrow
ovoid and requires perimeter filing. ovoid.
3. Apical third level: the canals, generally round, 2. Midroot level: the canal is less ovoid.
are shaped into round, tapered preparations. 3. Apical third level: the canal is round.
Preparation terminates at the cementodentinal The sweeping curve at the apical third is filed to a
junction, 0.5 to 1.0 mm from the radiographic gradual curve.
apex.
H. Ovoid funnel-shaped coronal cavity is modest in
D. Ovoid, coronal funnel-shaped preparation allows size and skewed slightly to the mesial, allowing
dbridement of the entire pulp chamber down to adequate room to instrument and fill the curved
the ovoid midcanal. The cavity is large enough apical third.
Average Length 21.4 mm One canal 85.5% Straight 39% Lingual Curve 3%
Maximum Length 23.7 mm One foramen Distal Curve 40% Bayonet Curve 7%
Minimum Length 19.1 mm Two canals* 1.5% Mesial Curve 0% Trifurcation Curve 1%
Range 4.6 mm One foramen Buccal Curve 10%
PLATE 19
PLATE 20
A. Entrance is always gained through the occlusal sur- D. Again, working at slow speed from inside to out-
face of all posterior teeth. Initial penetration is side, a round bur is used to remove the roof of the
made in the exact center of the mesial pit, with the pulp chamber. Internal walls and floor of prepara-
bur directed toward the lingual. The 702 U taper- tion should not be cut into unless difficulty is
ing fissure bur in an accelerated-speed encountered in locating orifices. In that case, surgi-
contra-angle handpiece is ideal for perforating cal-length No. 2 round burs are necessary to
gold casting or virgin enamel surface to the depth explore the floor of the chamber.
of dentin. Amalgam fillings are penetrated with a
No. 4 or 6 round bur operating in a slow-speed E. Final finish and funneling of cavity walls are com-
contra-angle handpiece. pleted with a 702 U fissure bur or tapered diamond
points at accelerated speed.
B. According to the size of the chamber, a
regular-length No. 4 round bur is used to open into F. Final preparation provides unobstructed access to
the pulp chamber. The bur should be directed canal orifices and should not impede complete
toward the orifice of the palatal canal or toward authority of enlarging instruments. Improve ease
the mesiobuccal canal orifice, where the greatest of access by leaning the entire preparation
space in the chamber exists. It will be felt to drop toward the buccal, for all instrumentation is intro-
when the pulp chamber is reached. If the chamber duced from the buccal. Notice that the preparation
is well calcified, initial penetration is continued extends almost to the height of the buccal cusps.
until the contra-angle rests against the occlusal The walls are perfectly smooth, and the orifices are
surface. This depth of 9 mm is the usual position of located at the exact pulpal-axial angles of the cavi-
the floor of the pulp chamber, which lies at the cer- ty floor.
vical level. Working from inside out, back toward G. Extended outline form reflects the anatomy of the
the buccal, the bur removes enough roof of the pulp chamber. The base is toward the buccal and
pulp chamber for exploration. the apex is to the lingual, with the canal orifice
C. An endodontic explorer is used to locate orifices of positioned at each angle of the triangle. The cavity
the palatal, mesiobuccal, and distobuccal canals. is entirely within the mesial half of the tooth and
Tension of the explorer against the walls of prepa- need not invade the transverse ridge but is exten-
ration will indicate the amount and direction of sive enough, buccal to lingual, to allow positioning
extension necessary. Orifices of canals form the of instruments and filling materials. Outline form
perimeter of preparation. Special care must be of final preparation is identical for both a newly
taken to explore for a second canal in the erupted and an adult tooth. Note the orifice to
mesiobuccal root. the fourth canal.
PLATE 21
Curvature of roots
Length of Tooth Mesiobuccal Distobuccal Palatal Canal Direction Palatal Mesial Distal Canals in the mesiobuccal root
Average Length 19.9 mm 19.4 mm 20.6 mm Three canals 41.1% Straight 40% 21% 54% One canal 41.1%
Maximum Length 21.6 mm 21.2 mm 22.5 mm Four canals 56.5% Distal Curve 1% 78% 17% One foramen
Minimum Length 18.2 mm 17.6 mm 17.6 mm Five canals 2.4% Mesial Curve 4% 0% 19% Two canals 40%
Range 3.4 mm 3.6 mm 3.8 mm *Buccal Curve *55% 0% 0% One foramen
*Lingual Curve 0% 0% 0% Two canals 18.9%
Bayonet Curve 0% 1% 10% Two foramina
*Not apparent in radiograph
PLATE 22
A. Buccal view of a recently calcified second molar to the buccal and is extensive enough to allow posi-
with a large pulp. A radiograph will reveal tioning of instruments and filling materials needed
1. large pulp chamber to enlarge and fill canals.
2. mesiobuccal, distobuccal, and palatal roots,
E. Buccal view of an adult second molar with exten-
each with one canal
sive secondary dentin formation.
3. gradual curvature of all three canals
A radiograph will reveal
4. vertical axial alignment of the tooth
1. pulp recession and thread-like pulp
These factors, seen in radiograph, are borne in
2. anomalous appearance of only one root and
mind when preparation is begun.
two canals
B. Mesial view of the same tooth demonstrating 3. vertical axial alignment of the tooth
details not apparent in the radiograph:
F. Mesial view of the same tooth demonstrating
1. buccolingual width of the pulp chamber
details not apparent in the radiograph:
2. gradual curvature in two directions of all three
1. pulp recession
canals
2. anomalous appearance of only one root and
3. buccal inclination of the buccal roots
two canals
4. vertical axial alignment of the tooth
3. sweeping curvature of the lingual canal
These unseen factors will affect the size, shape,
4. vertical axial alignment of the tooth
and inclination of the final preparation.
The operator must recognize that
C. Cross-section at two levels: 1, cervical; and 2, apical
a. canal orifices are difficult to find by explo-
third:
ration.
1. Cervical level: the pulp is enormous in a young
b. a detailed search must be made for the third
tooth. Dbridement of a triangular chamber is
canal.
completed with round burs. The dark cavity
floor with lines connecting orifices is in G. Cross-sections at two levels: 1, cervical; and 2, api-
marked contrast to white walls. cal third.
2. Apical third level: the canals are essentially 1. Cervical level: ovoid pulp chamber is dbrided
round and are shaped into a round, tapered during cavity preparation with a round bur.
preparation. Preparations terminate at the 2. Apical third level: canals are round. Preparations
cementodentinal junction, 0.5 to 1.0 from the terminate at the cementodentinal junction, 0.5
radiographic apex. to 1.0 mm from the radiographic apex.
D. Triangular outline form is flattened as it reflects H. Ovoid outline form reflects the internal anatomy of
the internal anatomy of the chamber. Note that the the pulp chamber and elongated parallelogram
distobuccal canal orifice is nearer the center of the shape of the occlusal surface. The entire prepara-
cavity floor. The entire preparation sharply slopes tion slopes sharply to the buccal.
Length of Tooth Mesiobuccal Distobuccal Palatal Number of Roots Direction Palatal Mesial Distal Canals in the mesiobuccal root
Average Length 20.2 mm 19.4 mm 20.8 mm Three 54% Straight 63% 22% 54% One canal 63%
Maximum Length 22.2 mm 21.3 mm 22.6 mm Fused 46% Distal 0% 54% ? One foramen
Minimum Length 18.2 mm 17.5 mm 19.0 mm Mesial 0% 0% 17% Two canals 13%
Range 4.0 mm 3.8 mm 3.6 mm *Buccal 37% One foramen
Lingual 0% Two canals 24%
Two foramina
*Not apparent in radiograph
PLATE 23
A. UNDEREXTENDED preparation. Pulp horns have D. INADEQUATE vertical preparation related to fail-
merely been nicked, and the entire roof of the ure to recognize severe buccal inclination of an
pulp chamber remains. White color dentin of the unopposed molar.
roof is a clue to underextension (A1). Instrument E. DISORIENTED occlusal outline form exposing only
control is lost. the palatal canal. A faulty cavity has been prepared in
B. OVEREXTENDED preparation undermining full crown, which was placed to straighten a rotat-
enamel walls. The crown is badly gouged owing to ed molar (E1). Palpating for mesiobuccal root
failure to observe pulp recession in the radiograph. prominence would reveal the severity of the rotation.
C. PERFORATION into furca using a surgical-length F. LEDGE FORMATION caused by using a large
bur and failing to realize that the narrow pulp straight instrument in a curved canal.
chamber had been passed. Operator error in failure G. PERFORATION of a palatal root commonly
to compare the length of the bur to the depth of the caused by assuming the canal to be straight and
pulp canal floor. Length should be marked on the failing to explore and enlarge the canal with a fine
bur shank with Dycal. curved instrument.
PLATE 24
A. Entrance is always gained through the occlusal sur- D. Again, working at slow speed from the inside to
face of all posterior teeth. Initial penetration is made outside, a round bur is used to remove the roof of
in the exact center of the mesial pit, with the bur the pulp chamber. Internal walls and floor of
directed toward the distal. The 702 U tapering fis- preparation should not be cut into unless difficul-
sure bur in an accelerated-speed contra-angle hand- ty is encountered in locating orifices. In that case,
piece is ideal for perforating gold casting or virgin surgical-length No. 2 or 4 round burs are necessary
enamel surface to the depth of dentin. Amalgam fill- to explore the floor of the chamber.
ings are penetrated with a No. 4 round bur operat-
ing in a high-speed contra-angle handpiece. E. Final finish and funneling of cavity walls are com-
pleted with a 702 U fissure bur or diamond point
B. According to the size of the chamber, a regular-length at accelerated speed.
No. 4 or 6 round bur is used to open into the pulp
chamber. The bur should be directed toward the ori- F. Final preparation provides unobstructed access to
fice of the mesiobuccal or distal canal, where the canal orifices and should not impede the complete
greatest space in the chamber exists. It will be felt to authority of enlarging instruments. Improve ease
drop when the pulp chamber is reached. If the of access by leaning the entire preparation
chamber is well calcified, initial penetration is con- toward the mesial, for all instrumentation is intro-
tinued until the contra-angle handpiece rests against duced from the mesial. Notice that the cavity out-
the occlusal surface. This depth of 9 mm is the usual line extends to the height of the mesial cusps. The
position of the floor of the pulp chamber, which lies walls are perfectly smooth and the orifices located
at the cervical level. Working from inside out, back at the exact pulpal-axial angle of the cavity floor.
toward the mesial, the bur removes enough roof of G. Square outline form reflects the anatomy of the
the pulp chamber for exploration. pulp chamber. Both mesial and distal walls slope
C. An endodontic explorer is used to locate orifices of mesially. The cavity is primarily within the mesial
the distal, mesiobuccal, and mesiolingual canals. half of the tooth but is extensive enough to allow
Tension of the explorer against the walls of prepa- positioning of the instrument and filling materi-
ration indicates the amount and direction of exten- als. The outline form of the final preparation will
sion necessary. Orifices of the canals form the be identical for both a newly erupted and an
perimeter of preparation. Special care must be adult tooth. Further exploration should deter-
taken to explore for an additional canal in the dis- mine if a fourth canal can be found in the distal. If
tal root. The distal canal should form a triangle so, the outline is extended in that direction. In that
with two mesial canals. If it is asymmetric, always case, an orifice will be positioned at each angle of
look for the fourth canal 29% of the time. the square.
PLATE 25
A. Buccal view of a recently calcified first molar with 4. distal-axial inclination of the tooth
large pulp. The initial radiograph will reveal
F. Mesial view of the same tooth demonstrating
1. large pulp chamber
details not apparent in the radiograph:
2. mesial and distal roots, each apparently con-
1. pulp recession
taining one canal
2. mesial root, two canals, and a single foramen
3. vertical distal root with a severe apical curvature
3. minus 58-degree buccal-axial inclination of
4. curvature of the mesial root (84% of the time)
the roots
5. distal-axial inclination of the tooth
These factors, seen in radiograph, are borne in The operator must recognize that
mind when preparation is begun. a. careful exploration with two instruments at the
same time reveals a common apical foramen.
B. Mesial view of the same tooth demonstrating
b. mesial canals curve in two directions.
details not apparent in the radiograph:
1. single mesial root with two canals G. Cross-section at three levels: 1, cervical; 2, midroot;
2. minus 58-degree buccal-axial inclination of and 3, apical third:
the roots 1. Cervical level: the chamber is dbrided during
All of these unseen factors will affect the size, coronal cavity preparation with a round bur.
shape, and inclination of the final preparation. 2. Midroot level: the canals are nearly round and
are enlarged during reaming of an apical third.
C. Cross-section at three levels: 1, cervical; 2, midroot;
3. Apical third level: the canals are round and are
and 3, apical third:
shaped into a round, tapered preparation.
1. Cervical level: the pulp, enormous in a young
Preparations terminate at the cementodentinal
tooth, is dbrided during coronal cavity prepa-
junction, 0.5 to 1.0 mm from the radiographic
ration with a round bur.
apex.
2. Midroot level: the canals are ovoid. Severe
indentation on the distal surface of the mesial H. Distal view of the same tooth demonstrating
root brings the canal within 1.5 mm of the details not apparent in the radiograph:
external surface, an area frequently perforated 1. pulp recession
by stripping. 2. distal root with the usual single canal
3. Apical third level: the canals are round and are 3. buccal-axial inclination of the roots
shaped into round, tapered preparations. 4. distal canal curves in two directions
Preparations terminate at the cementodentinal The operator should recognize that
junction, 0.5 to 1.0 mm from the radiographic a. the presence of a fourth canal can be deter-
apex. mined only by careful exploration.
D. Distal view of the same tooth demonstrating I. Triangular outline form reflects the anatomy of
details not apparent in the radiograph: the pulp chamber. Both mesial and distal walls
1. height of distal pulp horns slope mesially. The cavity is primarily within the
2. ribbon-shaped distal canal mesial half of the tooth but is extensive enough to
E. Buccal view of an adult first molar with extensive allow positioning of instruments and filling mate-
secondary dentin formation. A radiograph will reveal rials. Further exploration should determine
1. pulp recession and thread-like pulp whether a fourth canal can be found in the distal.
2. mesial and distal roots, each apparently con- In that case, an orifice will be positioned at each
taining one canal angle of the rhomboid.
3. mesial curvature of the distal root (5% of the
time) and distal curvature of the mesial root
(84% of the time)
Average 20.9 mm 20.9 mm Two roots 97.8% Two canals 6.7% Two canals 40.5% One canal 71.1% Straight 16% 74%
Length One foramen Distal 84% 21%
Maximum 22.7 mm 22.6 mm Three roots 2.2% Three canals 64.4% Two canals Two canals 28.9% Mesial 0% 5%
Length Two foramina 59.5% Buccal 0% 0%
Minimum 19.1 mm 19.2 mm Four canals 28.9% Two canals 61.5% Lingual 0% 0%
Length One foramen
Range 3.6 mm 3.4 mm Two canals 38.5%
Two foramina
PLATE 26
A. Buccal view of a recently calcified second molar 1. pulp recession and a thread-like pulp
with a large pulp. A radiograph will reveal 2. mesial and distal roots, each apparently con-
1. large pulp chamber taining one canal
2. mesial and distal roots, each apparently con- 3. straight distal root (58%) and distal curva-
taining one canal ture of the mesial root (84%)
3. mesial curvature of the distal root (10%) 4. distal-axial inclination of the tooth
4. bayonet curvature of the mesial root (7%)
F. Mesial view of the same tooth demonstrating
5. distal-axial inclination of the tooth
details not apparent in the original radiograph:
These factors, seen in radiograph, are borne in
1. pulp recession
mind when preparation is begun.
2. mesial root with two canals that join and cross
B. Mesial view of the same tooth demonstrating over
details not apparent in the radiograph: 3. minus 52-degree buccal-axial inclination of
1. mesial root with two canals the roots
2. lingual curvature of the mesiobuccal canal
3. S curvature of the mesiolingual canal The operator should recognize that
4. minus 52-degree buccal-axial inclination of a. careful exploration with curved instruments is
the roots imperative.
These unseen factors will affect the size, shape, and b. mesial canals curve in two directions.
inclination of the final preparation. Canals must be G. Cross-section at three levels: 1, cervical; 2, midroot;
carefully explored with a fine curved file. The dou- and 3, apical third:
ble S curvature of the mesiolingual canal is espe- 1. Cervical level: the chamber is dbrided during
cially challenging. All three canals are enlarged by coronal cavity preparation with a round bur.
step-back or step-down filing. 2. Midroot level: the canals, only slightly ovoid in
C. Cross-section at three levels: 1, cervical; 2, midroot; shape, will be enlarged by step-back filing of
and 3, apical third: the apical third of the canals.
1. Cervical level: the pulp, enormous in a young 3. Apical third level: the canals are round and are
tooth, is dbrided during coronal cavity prepa- shaped into round, tapered preparations.
ration with a round bur. Preparations terminate at the cementodentinal
2. Midroot level: the canals are ovoid. Carefully junction, 0.5 to 1.0 mm from the radiographic
avoid filing against the distal surface of the apex.
mesial root, where stripping perforation H. Distal view of the same tooth demonstrating
often occurs. details not apparent in the radiograph:
3. Apical third level: the canals are round and are 1. pulp recession
shaped into round, tapered preparations. 2. single distal root with a usual single canal
Preparations terminate at the cementodentinal 3. buccal-axial inclination of the tooth
junction, 0.5 to 1.0 mm from the radiographic
apex. I. Triangular outline form reflects the anatomy of
the pulp chamber. Both mesial and distal walls
D. Distal view of the same tooth demonstrating slope mesially. The cavity is primarily within the
details not apparent in the radiograph: mesial half of the tooth but is extensive enough to
1. height of the distal pulp horns allow positioning of instruments and filling mate-
2. ribbon-shaped distal canal rials. Further exploration should determine
E. Buccal view of an adult second molar with exten- whether a fourth canal can be found in the distal.
sive secondary dentin formation. A radiograph will In that case, an orifice will be found at each angle
reveal: of the rhomboid.
Curvature of roots
Canals
Single Double Root
Length of Tooth Mesial Distal Mesial Distal Direction Root Mesial Distal
Average Length 20.9 mm 20.8 mm One canal 13% 92% Straight 53% 27% 58%
Maximum Length 22.6 mm 22.6 mm One foramen Distal Curve 26% 61% 18%
Minimum Length 19.2 mm 19.0 mm Two canals 49% 5% Mesial Curve 0% 0% 10%
Range 3.4 mm 3.6 mm One foramen *Buccal Curve 0% 4% 4%
Two canals 38% 3% *Lingual Curve 2% 0% 0%
Two foramina Bayonet Curve 19% 7% 6%
*Not apparent in radiograph
PLATE 27
A B
Figure 10-8 A, Cross-section through pulp canal showing ideal round preparation to remove canal debris and enough dentin to eliminate
virtually all bacteria in the tubuli. B, Serial section showing necrotic canal contents and debris-saturated dentin. Dbridement of necrotic
mass and instrumentation of the dentin to the black line are the goals of instrumentation.
step-down approach. In either event, certain principles men. In some preparations, Retention Form may be
of cavity preparation (in this case, radicular and coro- developed in the last 2 to 3 mm of the apical canal.
nal) must be followed to ensure thorough cleaning and Usually, however, the preparation is a continuous
proper shaping for obturation. tapered preparation from crown to root end.
The entire length of the cavity falls under the rubric
Principles Outline Form and toilet of the cavity. At the coronal
Once again, as expounded for coronal cavity prepara- margin of the cavity, the Outline Form must be con-
tion, a return to Blacks Principles of Cavity Preparation tinually evaluated by monitoring the tension of the
is in order.1 The root canal cavity is prepared with the endodontic instruments against the margins of the cav-
same principles in mind: ity. Remember to retain control of the instruments;
they must stand free and clear of all interference. Access
Outline Form may have to be expanded (Convenience Form) if
Convenience Form instruments start to bind, especially as larger, less flexi-
Toilet of the cavity ble instruments are used.
Retention Form The size and shape of the entire preparation will be
Resistance Form governed by the anatomy of the root canal. One attempts
Extension for prevention to retain this basic shape while thoroughly cleaning and
flaring to accommodate the instruments and filling
Figure 10-9 repeats the entire endodontic cavity materials used in dbridement and obturation.
preparation, from Outline Form beginning at the The entire preparation, crown to apex, may be con-
enamels edge to Resistance Form at the apical fora- sidered extension for prevention of future periradicu-
lar infection and inflammation.
Retention Form
In some filling techniques, it is recommended that the
initial primary gutta-percha point fit tightly in the apical
2 to 3 mm of the canal. These nearly parallel walls
(Retention Form) ensure the firm seating of this princi-
Figure 10-9 Concept of total endodontic cavity preparation,
coronal and radicular as a continuum, based on Blacks principles. pal point. Other techniques strive to achieve a continu-
Beginning at apex: A, Radiographic apex. B, Resistance Form, ously tapering funnel from the apical foramen to the
development of apical stop at the cementodentinal junction cavosurface margin. Retention Form in these cases is
against which filling is to be compacted and to resist extrusion of gained with custom-fitted cones and warm compaction
canal debris and filling material. C, Retention Form, to retain pri- techniques.
mary filling point. D, Convenience Form, subject to revision as
needed to accommodate larger, less flexible instruments. External
These final 2 to 3 mm of the cavity are the most cru-
modifications change the Outline Form. E, Outline Form, basic cial and call for meticulous care in preparation. This is
preparation throughout its length dictated by canal anatomy. where the sealing against future leakage or percolation
into the canal takes place. This is also the region where
accessory or lateral canals are most apt to be present.
Coronally, from the area of retention, the cavity
walls are deliberately flared. The degree of flare will
vary according to the filling technique to be usedlat-
eral compaction with cold or warm gutta-percha or
vertical compaction of heat-softened gutta-percha.
Resistance Form
Resistance to overfilling is the primary objective of
Resistance Form. Beyond that, however, maintaining
the integrity of the natural constriction of the apical Figure 10-10 Instruments and filling material should terminate
foramen is a key to successful therapy. Violating this short of the cementodentinal junction, the narrowest width of the
canal, and its termination at the foramen. This point is often 0.5 to
integrity by overinstrumentation leads to complica-
1.0 mm from the apex.
tions: (1) acute inflammation of the periradicular tis-
sue from the injury inflicted by the instruments or bac-
teria and/or canal debris forced into the tissue, (2) mation builds up the apex. One is also reminded that the
chronic inflammation of this tissue caused by the pres- dentinocemental junction, where Resistance Form may
ence of a foreign bodythe filling material forced be established, is the apical termination of the pulp.
there during obturation, and (3) the inability to com- Beyond this point, one is dealing with the tissues of the
pact the root canal filling because of the loss of the lim- periodontal ligament space, not the pulp.
iting apical termination of the cavitythe important The fact must also be established that the apical
apical stop. This could be compared to an attempt to foramen does not always lie at the exact apex of the
place a Class II amalgam filling without the limiting root. Most often, canals exit laterally, short of the radi-
presence of a proximal matrix band. ographic apex. This may be revealed by careful scrutiny
of the film with a magnifying glass or by placing a
Establishing Apical Patency curved exploratory instrument to the exact canal
Bearing in mind that canal preparations should ter- length and repeating the radiograph examination.
minate at the dentinocemental junction, slightly Japanese researchers reported from a native cohort that
short of the apex, one is left with a tiny remaining the apical foramen exits the exact apex only 16.7% of
portion of the canal that has not been properly the time in maxillary anterior teeth.52
cleaned and may contain bacteria and packed debris.
It is this section of the canal that is finally cleaned, Extension for Prevention
not shaped, with fine instrumentsNo. 10 or 15 files. Seidler once described the ideal endodontic cavity as a
This action is known as establishing apical patency. It round, evenly tapered space with a minimal opening at
should not be confused with overenlargement the foramen.53 Because one is working with round,
destroying the apical foramen. Cailleteau and tapered materials, one would think that this ideal is eas-
Mullaney surveyed all dental schools in the United ily achieved, particularly when one thinks of root
States to determine the prevalence of teaching apical canals as naturally round and tapered. As seen in the
patency. They found that 50% of the 49 schools anatomic drawings in this chapter, however, few canals
responding teach the concept.50 are round throughout their length. Thus, one must
In some casesyoungsters, root fractures, apical root usually compromise from the ideal, attempting to pre-
resorptionthe apical foramen is open, and these cases pare the round, tapered cavity but knowing that filling
always present difficulties in instrumentation and obtu- techniques must be used to make up for the variance
ration. Special techniques, to be discussed later, have from ideal. This is why single-point fillings, whether
been devised to overcome the loss of resistance form. silver or gutta-percha, are seldom used.
In Mexico, Kuttler has shown that the narrowest waist The extension of the cavity preparation through-
of the apical foramen often lies at the dentinocemental out its entire length and breadth is necessary, howev-
junction (Figure 10-10).51 He established this point at er, to ensure prevention of future problems.
approximately 0.5 mm from the outer surface of the root Peripheral enlargement of the canal, to remove all of
in most cases. The older the patient, however, the greater the debris, followed by total obturation is the primary
this distance becomes because continued cemental for- preventive method.
INSTRUMENTS AND METHODS FOR RADICU- 1. A formula for the diameter and taper in each size of
LAR CLEANING AND SHAPING instrument and filling material was agreed on.
Before launching into a detailed or even a broad dis- 2. A formula for a graduated increment in size from
cussion of the methods and shapes of canal cavity one instrument to the next was developed.
preparation, a description of the instruments and 3. A new instrument numbering system based on
methods used in cleaning and shaping the canal is nec- instrument metric diameter was established.
essary. The order of their appearance during prepa-
ration will also be discussed: basic endodontic instru- After initial resistance by many manufacturers, who felt
ments, irrigation, exploration for canal orifices, explo- that the change would entail a considerable investment in
ration of the canal, and length of tooth determination. new dies and machinery to produce them, all manufac-
Then the techniques of intraradicular cavity prepara- turers, worldwide, eventually accepted the new sizing.
tion will follow in detail. Pulpectomy is discussed later. This numbering system, last revised in 2002,58 using
numbers from 6 to 140, was not just arbitrary but was
Basic Endodontic Instruments based on the diameter of the instruments in hun-
After years of relative inactivity, a remarkable upsurge in dredths of a millimeter at the beginning of the tip of
endodontic instrument design and refinement has the blades, a point called D0 (diameter 1) (Figure 10-
recently developed. Historically, very little was done to 11), and extending up the blades to the most coronal
improve the quality or standardization of instruments part of the cutting edge at D16 (diameter 2)16 mm
until the 1950s, when two research groups started in length. Additional revisions are under way to cover
reporting on the sizing, strength, and materials that instruments constructed with new materials, designs,
went into hand instruments.5457 After the introduction and tapers greater than 0.02 mm/mm.
of standardized instruments,57 about the only changes At the present time, instruments with a taper greater
made were the universal use of stainless rather than car- than the ISO 0.02 mm/mm have become popular: 0.04,
bon steel and the addition of smaller (Nos. 6 and 8) and
larger (No. 110 to 140) sizes as well as color coding and
the re-emergence of power-driven instruments.
By 1962, a working committee on standardization had
been formed including manufacturers, the American
Association of Endodontists (AAE), and the American
Dental Association (ADA). This group evolved into the
present-day International Standards Organization (ISO).
It was not until 1976, however, that the first approved
specification for root canal instruments was published
(ADA Specification No. 28), 18 years after Ingle and
Levine first proposed standardization in 1958.56
Endodontic Instrument Standardization
Before 1958, endodontic instruments were manufac-
tured without benefit of any established criteria.
Although each manufacturer used what seemed to be a
unified size system, the numbering (1 through 6) was
entirely arbitrary. An instrument of one company
rarely coincided with a comparable instrument of
another company. In addition, there was little unifor-
mity in quality control or manufacture, no uniformity
existed in progression from one instrument size to the Figure 10-11 Original recommendation for standardized instru-
next, and there was no correlation of instruments and ments. Cutting blades 16 mm in length are of the same size and
filling materials in terms of size and shape. numbers as standardized filling points. The number of the instru-
ment is determined by diameter size at D1 in hundredths of mil-
Beginning in 1955, a serious attempt was made to limeters. Diameter 2 (D2) is uniformly 0.32 mm greater than D1.
correct these abuses, and in 1959, a new line of stan- Reproduced with permission from Ingle JI. In: Grossman LI, editor.
dardized instruments and filling material was intro- Transactions of the Second International Conference on
duced to the profession56: Endodontics. Philadelphia: University of Pennsylvania; 1958. p. 123.
0.06, and 0.08. This means that for every millimeter for endodontic files and reamers (Figure 10-12). It
gain in the length of the cutting blade, the width established the requirements for diameter, length,
(taper) of the instrument increases in size by 0.04, 0.06, resistance to fracture, stiffness, and resistance to corro-
and 0.08 of a millimeter rather than the ISO standard sion. It also included specifications for sampling,
of 0.02 mm/mm. These new instruments allow for inspection, and test procedures.58 The revision to ADA
greater coronal flaring than the 0.02 instruments. Specification No. 28 for K-type files and reamers high-
In contrast to these widened-flare files, a number of lighted 30 years of work to achieve international stan-
manufacturers have issued half sizes in the 0.02 flare dardization (Table 10-1). Since then, Specification No.
2.5, 17.5, 22.5, 27.5, 32.5, and 37.5to be used in shap- 28 has been modified again (1996), and still another
ing extremely fine canals. revision is in progress.
The full extent of the shaft, up to the handle, comes The ANSI/ADA standards have also been set for
in three lengths: standard, 25 mm; long, 31 mm; and other instruments and filling materials: No. 58,
short, 21 mm. The long instruments are often neces- Hedstroem files; No. 63, rasps and barbed broaches;
sary when treating canines over 25 mm long. Shorter No. 71, spreaders and condensers; No. 95, root canal
instruments are helpful in second and third molars or enlargers; as well as No. 57, filling materials; No. 73,
in the patient who cannot open widely. Other special absorbent points; and No.78, obturating points. The
lengths are available, such as the popular 19 mm ISOs standards are comparable with these specifica-
instrument. tions (N Luebke, personal communication, March
Ultimately, to maintain these standards, the AAE 24, 1999).
urged the ADA and the United States Bureau of Initially, manufacturers of endodontic instruments
Standards to appoint a committee for endodontic worldwide adhered rather closely to these specifica-
instrument standardization. A committee was formed tions. Some variations have been noted, however, in size
and, after considerable work and several drafts, pro- maintenance (both diameter and taper), surface debris,
duced a specification package that slightly modified cutting flute character, torsional properties, stiffness,
and embellished Ingles original standardization.57 cross-sectional shape, cutting tip design, and type of
These pioneering efforts reached international propor- metal5965 (Figure 10-13). More recently, Stenman and
tions when a worldwide collaborative committee was Spangberg were disappointed to note that the dimen-
formed: the ISO, consisting of the Fdration Dentaire sions of root canal instruments are becoming poorly
International, the World Health Organization, and the standardized and that few brands are now within
ADA Instrument Committee. The ISO has now formu- acceptable dimensional standards.66
lated international specifications using the ADA pro- Cormier et al. and Seto have both warned of the
posal as a model. importance of using only one brand of instruments
In 1989, the American National Standards Institute because of discrepancies in instrument size among
(ANSI) granted approval of ADA Specification No. 28 manufacturers.61,62 Early on, Seto also noted that grind-
ing the flutes in files rather than twisting them does not
improve the strength or ductility of the instru-
ment(and) may also create more undesirable fluting
defects.63 Since then, however, grinding has improved
and gained importance since all nickel-titanium instru-
ments must be machined, not twisted. Several recent
studies have indicated that this type of manufacturing
does not weaken instruments. In fact, most studies indi-
cate that both manufacturing processes produce files
that meet or exceed ADA standards.6769
It has also been found that autoclaving has no sig-
nificant deleterious effects on stainless steel or nickel-
Figure 10-12 Standardized dimensions of root canal files and titanium endodontic instruments.7072
reamers established by the ISO. Two modifications from Ingles
original proposal are an additional measurement at D3, 3 mm from ISO Grouping of Instruments
D1, and specification for shapes of the tip: 75 degrees, 15 degrees.
The taper of the spiral section must be at a 0.02 mm gain for each
In due time, the ISO-Fdration Dentaire International
millimeter of cutting length. Specifications for a noncutting tip are committee grouped root canal instruments according
forthcoming. to their method of use:
Table 10-1 Dimensions in Millimeters. Revision of endodontic instruments worldwide. Now made univer-
ADA Specification No. 28 Added Instrument Sizes 08 sally of nickel titanium and stainless steel rather than
and 110 to 150 to the Original Specification carbon steel, K-type instruments are produced using one
of two techniques. The more traditional is produced by
Diameter (Tolerance 0.02 mm)
Handle grinding graduated sizes of round piano wire into var-
Size D1 mm D2 mm D3 mm Color Code ious shapes such as square, triangular, or rhomboid. A
08 0.08 0.40 0.14 Gray second grinding operation properly tapers these pieces.
10 0.10 0.42 0.16 Purple To give the instruments the spirals that provide the cut-
15 0.15 0.47 0.21 White ting edges, the square or triangular stock is then grasped
20 0.20 0.52 0.26 Yellow by a machine that twists it counterclockwise a pro-
25 0.25 0.57 0.31 Red grammed number of timestight spirals for files, loose
30 0.30 0.62 0.36 Blue spirals for reamers. The cutting blades that are produced
35 0.35 0.67 0.41 Green are the sharp edges of either the square or the triangle. In
40 0.40 0.72 0.46 Black any instrument, these edges are known as the rake of
45 0.45 0.77 0.51 White the blade. The more acute the angle of the rake, the
50 0.50 0.82 0.56 Yellow sharper the blade. There are approximately twice the
55 0.55 0.87 0.61 Red number of spirals on a file than on a reamer of a corre-
60 0.60 0.92 0.66 Blue sponding size (Figure 10-15, A, B).
70 0.70 1.02 0.76 Green The second and newer manufacturing method is to
80 0.80 1.12 0.86 Black grind the spirals into the tapered wire rather than twist
90 0.90 1.22 0.96 White the wire to produce the cutting blades. Grinding is
100 1.00 1.32 1.06 Yellow totally necessary for nickel-titanium instruments.
110 1.10 1.42 1.16 Red Because of their superelasticity, they cannot be twisted.
120 1.20 1.52 1.26 Blue Originally, the cross-section of the K file was square
130 1.30 1.62 1.36 Green and the reamer triangular. Recently, manufacturers
140 1.40 1.72 1.46 Black have started using many configurations to achieve bet-
150 1.50 1.82 1.56 White ter cutting and/or flexibility. Cross-section is now the
prerogative of individual companies.
*New diameter measurement point (D3) was added 3 mm from K-Style Modification. After having dominated the
the tip of the cutting end of the instrument. Handle color cod- market for 65 years, K-style endodontic instruments
ing is official.
came into a series of modifications beginning in the
1980s. Not wholly satisfied with the characteristics of
Group I: Hand use onlyfiles, both K type (Kerr) their time-honored K-style instrument, the Kerr
and H type (Hedstroem); reamers, K type and U Manufacturing Company in 1982 introduced a new
type; and broaches, pluggers, and spreaders. instrument design that they termed the K-Flex File
Group II: Engine-driven latch typesame design as (Sybron Endo/Kerr; Orange Calif.), a departure from the
Group I but made to be attached to a handpiece. Also square and triangular configurations (Figure 10-15, C).
included are paste fillers. The cross-section of the K-Flex is rhombus or dia-
Group III: Engine-driven latch typedrills or mond shaped. The spirals or flutes are produced by the
reamers such as Gates-Glidden (G type). Peeso (P same twisting procedure used to produce the cutting
type), and a host of othersA-, D-, O-, KO-, T-, edge of the standard K-type files; however, this new
M-type reamers and the Kurer Root-Facer. cross-section presents significant changes in instru-
Group IV: Root canal pointsgutta-percha, silver, ment flexibility and cutting characteristics. The cutting
paper. edges of the high flutes are formed by the two acute
angles of the rhombus and present increased sharpness
The ISO grouping of endodontic instruments makes and cutting efficiency. The alternating low flutes
convenient a discussion by group of their manufacture, formed by the obtuse angles of the rhombus are meant
use, cutting ability, strengths, and weaknesses. to act as an auger, providing more area for increased
ISO Group I Instruments, Reamers, or Files. First debris removal. The decreased contact by the instru-
designed as early as 1904 by the Kerr Manufacturing ment with the canal walls provides a space reservoir
Company (Figure 10-14), K-style files and reamers are that, with proper irrigation, further reduces the danger
the most widely copied and extensively manufactured of compacting dentinal filings in the canal.
A B
C D
E F
Figure 10-13 Comparisons of the condition of unused instruments from different manufacturers. A, New No. 30 K file with consistently
sharp blades and point. B, New No. 35 K file, different brand, exhibiting dull blades. C, Cross-sectional profile of triangular No. 20 file show-
ing consistency in angles. D, Cross-section of competing No. 20 file with dull, rounded angles of cutting blades. E, No. 15 file showing lack
of consistency in the blade, reflecting poor quality control. F, New No. 08 file with no cutting blades at all.
The tactile sensation of an endodontic instrument considerably higher.74 Webber et al. found that instru-
set into the walls in the canal may be gained by ments with triangular cross sections were initially more
pinching one index finger between the thumb and fore- efficient but lost sharpness more rapidly than square
finger of the opposite hand and then rotating the ones of the same size.75
extended finger (Figure 10-16). Oliet and Sorin also found that wear does not
To summarize the basic action of files and reamers, appear to be a factor in instrument function, but rather
it may be stated that either files or reamers may be used instruments generally fail because of deformation or
to ream out a round, tapered apical cavity but that files fracture of the blades. Once an instrument became per-
are also used as push-pull instruments to enlarge by manently distorted, additional rotation only caused
rasping certain curved canals as well as the ovoid por- additional distortion, with minimum cutting frequent-
tion of large canals. In addition, copious irrigation and ly leading to fracture.74 A more recent in vitro study of
constant cleansing of the instrument are necessary to stainless steel files at Connecticut demonstrated that
clear the flutes and prevent packing debris at or significant wear and potential loss of efficiency occurred
through the apical foramen (Figure 10-17). after only one use of 300 strokes. They proposed that
The subject addressedhow K-style files and ream- endodontic instruments should be available in sterile
ers workmust logically be followed by asking how packaging for single-patient use.76 Another study, from
well they work. One is speaking here, primarily, about Brazil, concluded that stainless steel instruments, in
stainless steel instruments. small sizes, should be used once, and the No. 30 could
Oliet and Sorin evaluated endodontic reamers from be used three times. The No. 30 nickel-titanium instru-
four different manufacturers and found considerable ments, however, even after five times, did not show
variation in the quality, sharpness of the cutting edges, appreciable abnormalities in shape.77 Most endodon-
cross sectional configuration, and number of flutes of tists use the small instruments, 08 to 25 sizes only once.
the 147 different reamers tested. They further found Webber et al. used a linear cutting motion in moist
that triangular cross sectional reamers cut with greater bovine bone and found that there was a wide range of
efficiency than do the square cross sectional reamers, cutting efficiency between each type of root canal
but the failure rate of the triangular instruments was instrument, both initially and after successive use.75
Figure 10-16 Demonstration of sensation of an endodontic Figure 10-17 Worm of necrotic debris forced from the apex
instrument, which is set into dentin walls during reaming action. during canal enlargement. This mass of material could contain mil-
lions of bacteria that act as a nidus for acute apical abscess.
Similar findings were made by a group at Marquette instruments. In addition, Luks has shown that the
University, who compared K-type files with five recent- smaller reamers and files may be easily broken by twist-
ly introduced brands in three different sizes, Nos. 20, 25, ing the blades beyond the limits of the metal until the
and 30.78 Significant differences were noted in the in metal separated.80 On the other hand, Gutierrez et al.
vitro cutting efficiency among the seven brands. Wear found that although the instrument did not immedi-
was exhibited by all instruments after three successive 3- ately break, a progression of undesirable features
minute test periods. Depth of groove is also a significant occurred.81 Locking and twisting clockwise led to
factor in improving cutting ability (Figure 10-18). unwinding and elongation as well as the loss of blade
A group of researchers in Michigan also studied the cutting edge and blunting of the tip. With continued
cutting ability of K-type files.79 They reported a wide clockwise twisting, a reverse roll-up occurred. Cracks
variance in the cutting ability of individual files. This in the metal eventually developed that finally resulted
study appears to confirm what dentists have long in breakage, with all of its attendant problems. These
notedthe wide variance in cutting ability among findings were unusual in that breakage would have nor-
individual instruments, even from the same manufac- mally resulted long before roll-up occurred. It may
turer. Contrary to the Marquette findings,78 this study reflect a variance in the quality of metal used by the
reported an insignificant role played by wear in individual manufacturing companies. This point was
decreasing the cutting ability of regular K-type stainless borne out in a study by Lentine, in which he found a
steel files.79 This speaks of the strength of instruments, wide range of values within each brand of instrument
but what of their weaknesses? as well as between brands.82
The Oliet and Sorin,74 Webber et al.75 and Neal et An additional study of 360-degree clockwise rota-
79
al. studies all alluded to certain weaknesses in K-style tion (ISO revision of ADA Specification No. 28) found
Figure 10-18 Comparison between two competing brands of endodontic instruments showing widely different cutting ability related to the
depth of the blade groove.
only 5 K-style files failing of 100 instruments tested. found that most damage (87%) occurred while filing
They were sizes 30 to 50, all from one manufacturer.73 canals in posterior teeth with #10 stainless files. One file
Attempts to unscrew a locked endodontic file also separated for every 3.91 posterior teeth that were filed,
present a problem. Researchers at Northwestern and each student averaged over 5 (range 1 to 11) dam-
University demonstrated that endodontic files twisted aged files in the exercise.87
in a counterclockwise manner were extremely brittle in A group in France compared instrument fracture
comparison to those twisted in a clockwise manner.83 between traditional K and H files and the newer
They warned that dentists should exercise caution hybrid instruments. They found that the instru-
when backing-off embedded root canal instruments. ments with triangular cross sections, in particular the
This finding was strongly supported by Lautenschlager Flexofile (Dentsply/Maillefer; Tulsa, Okla.), were found
and colleagues, who found that all commercial files to be the most resistant to fracture. French researchers,
and reamers showed adequate clockwise torque, but like the Japanese researchers, found starting-point
were prone to brittle fracture when placed in counter- cracks and ductile fracture as well as plastic deforma-
clockwise torsion.84 tions and axial fractures88 (Figure 10-21).
In contrast, Roane and Sabala at the University of A group at the University of Washington compared
Oklahoma found that clockwise rotation was more rotation and torque to failure of stainless steel and
likely (91.5%) to produce separation and/or distortion nickel-titanium files of various sizes. An interesting
than counterclockwise rotation (8.5%) when they relation was noted. Stainless steel had greater rotations
examined 493 discarded instruments.85 In laboratory to failure in a clockwise direction, and the nickel titani-
tests, the Washington group also found greater rota- um was superior in a counterclockwise direction.
tional failure in clockwise rotation and greater failure Despite these differences, the actual force to cause fail-
in machined stainless steel K files over twisted K files.63 ure was the same.89
Sotokawa in Japan also studied discarded instru- Buchanan, among others, pointed out the importance
ments and indicted metal fatigue as the culprit in break- of bending stainless steel files to conform to curved
age and distortion86: First a starting point crack devel- canals. He recommended the use of pliers to make the
ops on the files edge and then metal fatigue fans out proper bend.90 Yesilsoy et al. on the other hand, observed
from that point, spreading towards the files axial cen- damage (flattening of the flutes) in cotton plier-bent files
ter (Figure 10-19). Sotokawa also classified the types of (Figure 10-22, A). The finger-bent files, however,
damage to instruments (Figure 10-20). He found the although not damaged, were coated with accumulated
No. 10 file to be the most frequently discarded.86 debris-stratified squamous epithelium cells and nail ker-
Montgomery evaluated file damage and breakage atin91 (Figure 10-22, B). Finger-bent files should be bent
from a sophomore endodontics laboratory and also while wearing washed rubber gloves or between a sterile
A B
Figure 10-19 Instrument breakage. A, Initial crack across the shaft near the edge of the blade, Type V (original magnification 1,000). B,
Full fracture of file broken in a 30-degree twisting simulation, Type VI ( original magnification 230). Reproduced with permission from
Sotokawa T.86
A B
Figure 10-21 Instrument fracture by cracks and deformation. A, Broken Hedstroem file with starting point at i (far right) spreading to
cracks (S) and ductile fracture (F). B, Broken K-Flex file with plastic deformations at D and axial fissure at Fs. Reproduced with permission
from Haikel Y et al.88
A B
Figure 10-22 Instruments precurved with cotton pliers or fingers. A, Cotton plier-precurved No. 25 file with attached metal chips, left.
Flutes are badly damaged. B, Finger-precurved No. 25 file with accumulated cellular debris between flutes. Reproduced with permission from
Yesilsoy C et al.91
gauze sponge. Maillefer manufactures a hand tool called cy than flutes and that triangular pyramidal tips out-
a Flexobend (Dentsply/Maillefer; Tulsa, Okla.) for prop- performed conical tips, which were least effective.96,97
erly bending files without damage. At the same time that a pitch was being made for the
To overcome the problems chronicled abovedistor- importance of cutting tips, other researchers, centered
tion, fracture, and precurvaturea group at Marquette around the University of Oklahoma, were redesigning
University suggested that nickel titanium, with a very tips that virtually eliminated their cutting ability. Powell
low modulus of elasticity, be substituted for stainless et al. began modifying the tips of K files by grinding to
steel in the manufacture of endodontic instruments.92 remove the transition angle from tip to first blade.98,99
On the other hand, the cutting efficiency of the Nitinol This was an outgrowth of Powells indoctrination at the
#35 K files was only 60% that of matching stainless University of Oklahoma by Roane et al.s introduction
steel files.93 of the Balanced Force concept of canal preparation.100
Tip Modification. Early interest in the cutting By 1988, Sabala et al. confirmed previous findings
ability of endodontic instruments centered around the that the modified tip instruments exerted less trans-
sharpness, pitch, and rake of the blades. By 1980, inter- portation and more inner curvature preparation. The
est had also developed in the sharpness of the instru- modified files maintained the original canal curvature
ment tip and the tips effect in penetration and cutting better and more frequently than did the unmodified
as well as its possible deleterious potential for ledging files.101 These findings were essentially confirmed in
and/or transportationmachining the preparation vitro by Sepic et al.102 and in vivo by McKendry et al.103
away from the natural canal anatomy. Powell et al. noted that each stainless steel files
The Northwestern University group noted that tip metallic memory to return to a straight position,
design, as much as flute sharpness, led to improved cut- increases the tendency to transport or ledge and eventu-
ting efficiency.94 They later designed experiments to ally to perforate curved canals.99 This action takes place
exclude tip design because the tip might overshadow on the outer wall, the convex curvature of the canal.
the cutting effects of flute design.95 Somewhat later, They pointed out that when this tip angle is reduced,
they reported that tips displayed better cutting efficien- the file stays centered within the original canal and cuts
all sides (circumference) more evenly. This modified-tip design, they are also more efficient as files per se.105110
file has been marketed as the Flex-R-file (Moyco/Union French clinicians (Yguel-Henry et al.) reported on the
Broach, Miller Dental; Bethpage, N.Y.) (Figure 10-23). importance of the lubricating effect of liquids on cut-
Recognizing the popularity of modified-tip instru- ting efficiency, raising this efficiency by 30% with H-
ments, other companies have introduced such instru- style files and 200% with K-files.108 Temple University
ments as Control Safe files (Dentsply/Maillefer; Tulsa, researchers, however, reported the proclivity that H
Okla.), the Anti-Ledging Tip file (Brasseler; Savannah, files have for packing debris at the apex.106 On the
Ga.), and Safety Hedstrom file (Sybron Endo/Kerr; other hand, El Deeb and Boraas found that H files
Orange, Calif.). tended not to pack debris at the apex and were the
At the University of Wales, rounded-tipped files most efficient.110
were compared with other files with triangular cross- Owing to their inherent fragility, Hedstroem files are
sections and various forms of tip modification. not to be used in a torquing action. For this reason,
Although the round-tipped files were the least efficient, ADA Specification No. 28 could not apply, and a new
they prepared canals more safely and with less destruc- specification, No. 58, has been approved by the ADA
tion than did the other files.104 and the American National Standards Committee.111
Hedstroem Files (aka Hedstrom). H-type files are H-Style File Modification. McSpadden was the
made by cutting the spiraling flutes into the shaft of a first to modify the traditional Hedstroem file. Marketed
piece of round, tapered, stainless steel wire. Actually, the as the Unifile and Dynatrak, these files were designed
machine used is similar to a screw-cutting machine. This with two spirals for cutting blades, a double-helix
accounts for the resemblance between the Hedstroem design, if you will. In cross-section, the blades present-
configuration and a wood screw (Figure 10-24, A). ed an S shape rather than the single-helix teardrop
It is impossible to ream or drill with this instrument. cross-sectional shape of the true Hedstroem file.
To do so locks the flutes into the dentin much as a Unfortunately, breakage studies revealed that the
screw is locked in wood. To continue the drilling action Unifile generally failed the torque twisting test (as did the
would fracture the instrument. Furthermore, the file is four other H files tested) based on ISO Specification No.
impossible to withdraw once it is locked in the dentin 58.112 The authors concluded that the specification was
and can be withdrawn only by backing off until the unfair to H-style files, that they should not be twisted
flutes are free. This action also separates files. more than one quarter-turn.73,112 At this time, Unifiles
Hedstroem files cut in one direction onlyretrac- and Dynatraks are no longer being marketed; however,
tion. Because of the very positive rake of the flute the Hyflex file (Coltene/Whaledent/Hygenic, Mahwah,
Figure 10-23 Flex-R-file with noncutting tip. A, Note rounded tip. B, Nose view of a noncutting tip ensures less gouging of the external
wall and reduced cavity transport. (Courtesy of Moyco Union Broach Co.)
Figure 10-25 A, Cross-sectional view of a U File reveals six corners in cutting blades compared with four corners in square stock and three
corners in triangular stock K files. B, Nickel-titanium U-shaped files in C-shaped molar canals. Note extreme flexibility (arrow) without sep-
aration. (A courtesy of Derek Heath, Quality Dental Products. B courtesy of Dr. John McSpadden.)
files are used in both a push-pull and rotary motion and although Briseno et al. compared Flexogates and Canal
are very adaptable to nickel-titanium rotary instru- Master (Brasseler, Savannah, Ga.) in vitro and found
ments. ProFiles are supplied in 0.04, 0.05, 0.06, 0.07, Flexogates less likely to cause apical transportation
and 0.08 tapers and ISO tip sizes of 15 through 80. (Figure 10-27).118
GT ProFiles, developed by Buchanan in the U design, Quantec Files. The newly designed Quantec
are unusual in that the cutting blades extend up the shaft instrument (Sybron-Endo/Kerr; Orange, Calif.), although
only 6 to 8 mm rather than 16 mm, and the tapers start called a file, is more like a reamera drill, if you will.
at 0.06 mm/mm (instead of 0.02), as well as 0.08 and It is not designed to be used in the files push-pull action
0.10, tapered instruments. They are made of nickel tita- but rather in the reamers rotary motion. Produced as
nium and come as hand instruments and rotary files. GT both hand- and rotary-powered instruments, the
instruments all start with a noncutting tip ISO size 20. Quantec has proved to be very effective as a powered
An unusual variation of the U-shaped design is the instrument. First designed by McSpadden, the instru-
LIGHTSPEED instrument114117 (Figure 10-26). Made ment has undergone a number of modifications that
only in nickel titanium, it resembles a Gates-Glidden have improved its efficiency and safety. Quantec is pro-
drill in that it has only a small cutting head mounted duced in three different tapers0.02, 0.04, and 0.06
on a long, noncutting shaft. It is strictly a rotary instru- mm/mmas well as safe-cutting and noncutting tips
ment but comes with a handle that may be added to the (Figure 10-28). The instruments are sized at the tip and
latch-type instrument for hand use in cleaning and numbered according to the ISO system15, 20, 25, etc.
shaping abrupt apical curvatures where rotary instru- The radial lands of the Quantec are slightly relieved to
ments may be in jeopardy. The instruments come in reduce frictional contact with the canal wall, and the
ISO sizes beginning with No. 20 up to No. 100. Half helix angle is configured to efficiently remove debris.
sizes begin at ISO 22.5 and range to size 65. The heads Hand Instrument Conclusions. The literature is
are very shortonly 0.25 mm for the size 20 and up to replete with references to the superiority of one instru-
1.75 mm for the size 100. ment or one method of preparation over all oth-
It is recommended that the LIGHTSPEED be used at ers.110,119122 Quite true is the statement, Regardless of
1,300 to 2,000 rpm and that the selected rpm remain the instrument type, none was able to reproduce ideal
constant. As with many of the new rotary instruments,
this speed calls for a controlled, preferably electric
handpiece. One of LIGHTSPEEDs touted advantages
is the ability to finish the apical-third preparation to a
larger size if dictated by the canal diameter. It has been
said that canal diameter, particularly in the apical
third, is a forgotten dimension in endodontics (per-
sonal communication, Dr. Carl Hawrish, 1999).
Gates-Glidden Modification. A hand instrument
also designed for apical preparation is the Flexogates,
aka Handygates (Dentsply/Maillefer; Tulsa, Olka.). A
safe-tipped variation of the traditional Gates-Glidden
drill, the Flexogates is still to be tested clinically,
Figure 10-29 A, Barbed broach. As a result of a careless barbing process, the effective shaft diameter is greatly reduced. Size coarse. B,
Ductile failure of size xx fine barbed broach fractured after axial twisting greater than 130 degrees. C, Brittle failure of coarse broach caused
by twisting while jammed in place. Reproduced with permission from Rueggeberg FA and Powers JM.125
as compared with only 500 MPa for a nickel-titanium Specification No. 28. However, when reviewing the lit-
wire.129 At 3% strain, the music wire breaks. On the erature on this subject the results seem to be mixed.
other hand, the nickel-titanium wire can be stretched Canalda and Berastequi found nickel-titanium files
much beyond 3% and can recover most of this defor- (Nitiflex and Naviflex) (Dentsply; Tulsa, Okla.) to be
mation on the release of stress. more flexible than the stainless files tested (Flexofile and
The superelastic behavior of nickel titanium also Flex-R).134 However, the stainless steel files were found
occurs over a limited temperature window. Minimum to be more resistant to fracture. Both types of metal
residual deformation occurs at approximately room exceeded all ANSI/ADA specifications. Canalda et al., in
temperature.129 A composition consisting of 50 atomic another study, compared identical instruments:
percent nickel and 50 atomic percent titanium seems CanalMaster (aka LIGHTSPEED) stainless steel and
ideal, both for instrumentation and manufacture. CanalMaster nickel titanium. Within these designs, the
Manufacture. Today, nickel-titanium instruments nickel-titanium values were superior in all aspects to
are precision ground into different designs (K style, those of stainless steel of the same design.135
Hedstrom, Flex-R, X-double fluted, S-double fluted, U Tepel et al. looked at bending and torsional proper-
files, and drills) and are made in different sizes and ties of 24 different types of nickel-titanium, titanium-
tapers. In addition, spreaders and pluggers are also aluminum, and stainless steel instruments.136 They
available. Nickel-titanium instruments are as effective found the nickel-titanium K files to be the most flexi-
or better than comparable stainless steel instruments in ble, followed in descending order by titanium alu-
machining dentin, and nickel-titanium instruments are minum, flexible stainless steel, and conventional stain-
more wear resistant.130 U and drill designs make it pos- less steel. When testing for resistance to fracture for 21
sible to use mechanical (ie, rotary handpiece) instru- brands, however, they found that No. 25 stainless steel
mentation. Moreover, new prototype rotary motors files had a higher resistance to fracture than their nick-
now offer the potential for improved torque control el-titanium counterpart.136
with automatic reversal that may ultimately decrease Wolcott and Himel, at the University of Tennessee,
rotary instrument breakage. compared the torsional properties of stainless steel K-
Finally, nickel-titanium files are biocompatible and type and nickel-titanium U-type instruments. As in
appear to have excellent anticorrosive properties.131 In previous studies, all of the stainless steel instruments
addition, implantation studies have verified that nickel showed no significant difference between maximum
titanium is biocompatible and acceptable as a surgical torque and torque at failure, whereas the nickel-titani-
implant.132 In a 1997 AAE questionnaire, the endodon- um instruments showed a significant difference
tic membership answered the following question, Do between maximum torque and torque at failure.137
you think nickel-titanium instruments are here to stay Essentially, this means that the time between wind-
and will become basic armamentaria for endodontic up and fracture in nickel-titanium instruments is
treatment? The responses were quite positive: yes, extended, which could lead to a false sense of security.
72%; maybe, 21%; and no, 4%.133 While studying cyclic fatigue using nickel-titanium
With the ability to machine flutes, many new designs LIGHTSPEED instruments, Pruett et al. determined
such as radial lands have become available. Radial lands that canal curvature and the number of rotations
allow nickel-titanium files to be used as reamers in a 360- determined file breakage. Separation occurred at the
degree motion as opposed to the traditional reamers with point of maximum curvature of the shaft.138 Cyclic
more acute rake angles. Although the most common use fatigue should be considered a valid term, even for
of this new design has been as a rotary file, the identical hand instrumentation, in light of the fact that many
instrument is available as a hand instrument. In addition, manufacturers are placing handles on files designed for
a converter handle is available that allows the operator to rotational use.
use the rotary file as a hand instrument. From these studies, it seems that if the clinician is
Torsional Strength and Separation. The clinician changing from a high-torque instrument, such as
switching from stainless to nickel-titanium hand instru- stainless steel, to a low-torque instrument, such as
ments should not confuse nickel titaniums superelastic nickel titanium, it would be wise to know that nickel-
characteristics with its torsional strength and so assume titanium instruments are more efficient and safer
that it has super strength. This misconception has led to when used passively.
unnecessary file breakage when first using this new Although instrument breakage should be rare, any
metal. Studies indicate that instruments, whether stain- instrument, hand or rotary, can break. It is the clini-
less steel or nickel titanium, meet or exceed ANSI/ADA cians knowledge and experience, along with the manu-
facturers quality control, that will ultimately minimize Consider discarding a file after abusive use in
breakage. At both the University of Tennessee and calcified or severely curved canals even though it
University of California at Los Angeles, breakage has not has been used only in one tooth. Use new files in
increased with the routine use of nickel-titanium hard cases and older files in easier cases. No one
instruments. If breakage occurs, the fractured piece can knows the maximum or ideal number of times a file
occasionally be removed or bypassed using ultrasonics can be used. Follow manufacturers instructions
and hand instruments in conjunction with magnifica- and the rule of being better safe than sorry. Once
tion. The dentist having problems with file breakage only is the safest number.
should seek help in evaluating his technique. One 5. Instrument fatigue occurs more often during the ini-
should practice on extracted teeth until a level of confi- tial stages of the learning curve. The clinician chang-
dence is reached that will help ensure safe and efficient ing from stainless steel to nickel titanium should take
patient care. continuing education courses with experienced clini-
The following is a list of situations that place nickel- cians and educators, followed by in vitro practice on
titanium hand instruments at risk along with sugges- plastic blocks and extracted teeth. Break files in
tions for avoiding problems: extracted teeth! Developing a level of skill and confi-
dence allows one to use the technique clinically.
Nickel-Titanium Precautions and Prevention 6. Ledges that develop in a canal allow space for
deflection of a file. The nickel-titanium instrument
1. Often too much pressure is applied to the file. Never can then curve back on itself. A nickel-titanium
force a file! These instruments require a passive instrument should not be used to bypass ledges.
technique. If resistance is encountered, stop imme- Only a small curved stainless steel file should be
diately, and before continuing, increase the coronal used, as described, in another section of this text.
taper and negotiate additional length, using a small- 7. Teeth with S-type curves should be approached
er, 0.02 taper stainless steel hand file. Stainless steel with caution! Adequate flaring of the coronal third
files should be used in sizes smaller than a No. 15. If to half of the canal, however, will decrease problems
one is using more finger pressure than that required in these cases. It may also be necessary to go
to break a No. 2 pencil lead, too much pressure is through a series of instruments an additional time
being used. Break a sharp No. 2 pencil lead and see or two in more difficult cases.
how little pressure is required! 8. If the instrument is progressing easily in a canal and
2. Canals that join abruptly at sharp angles are often then feels as if it hits bottom, DO NOT APPLY
found in roots such as the mesiobuccal root of max- ADDITIONAL PRESSURE! This will cause the
illary molars, all premolars, and mandibular incisors instrument tip to bind. Additional pressure applied
and the mesial roots of mandibular molars. The at this point may cause weakening or even breakage
straighter of the two canals should first be enlarged of the instrument. In this situation, remove the
to working length and then the other canal, only to instrument and try a smaller, 0.02 taper hand
where they join. If not, a nickel-titanium file may instrument, either stainless steel or nickel-titanium,
reverse its direction at this juncture, bending back carefully flaring and enlarging the uninstrumented
on itself and damaging the instrument. apical portion of the canal.
3. Curved canals that have a high degree and small 9. Avoid creating a canal the same size and taper of the
radius of curvature are dangerous.138 Such curva- instrument being used. The only exception is in the
tures (over 60 degrees and found 3 to 4 mm from use of the Buchanan GT file concept (to be dis-
working length) are often seen in the distal canals of cussed later). On removal from the canal, the debris
mandibular molars and the palatal roots of maxil- pattern on the file should be examined. Debris
lary first molars. should appear on the middle portion of the file.
4. Files should not be overused! All clinicians have Except for negotiating calcified canals and enlarging
experienced more fracture after files have been used the apical portion of the canal, the tip and coronal
a number of times. Remember that all uses of a file section of the file should not carry debris. Avoid
are not equal. A calcified canal stresses the file more cutting with the entire length of the file blade. This
than an uncalcified canal. A curved canal stresses total or frictional fit of the file in the canal will cause
the file more than a straight canal. One must also the instrument to lock.
bear in mind operator variability and the use of If this occurs, rotate the instrument in a counter-
lubricants, which will affect stress. clockwise direction and remove it from the canal.
The greater the distance a single file is advanced into files in the second block. Standardized photographs
the canal, the greater will be the chance of files lock- were taken of the blocks before and after instrumenta-
ing up. When the file feels tight throughout the tion. Overlay tracings were made of these photographs,
length of blade, it is an indication that the orifice and and differences in the shapes of the before and after
coronal one-third to two-thirds of the canal need drawings were measured.
increased taper. Instruments of varying design The nickel-titanium blocks received a higher grade
and/or taper can be used to avoid frictional fit. 67.9% of the time and the stainless steel blocks 14.8%
Nickel-titanium instruments with tapers from 0.04, of the time. Working length was maintained signifi-
0.06, and greater, as well as Gates-Glidden drills and cantly more often (p < .05) in the nickel-titanium
sonic/ultrasonic instruments, serve this purpose well. group than in the stainless steel group. There was no
10. Sudden changes in the direction of an instrument ledging of canals using the more flexible nickel-titani-
caused by the operator (ie, jerky or jabbing move- um files compared with 30.4% ledging when stainless
ments) must be avoided. A smooth gentle reaming steel files were used. When using nickel-titanium files,
or rotary motion is most efficient. the students were short of working length in only 3% of
11. As with any type of instrument, poor access prepa- the canals compared with 46% of the canals when
ration will lead to procedural errors. using stainless steel files. Although the canals were
12. Advancing or pushing an instrument into a canal in instrumented beyond the intended working length in
too large an increment causes it to act as a drill or 25% of the nickel-titanium blocks, the students were
piston and greatly increases stress on the metal. able to develop an apical stop within 1 mm between
Except for the most difficult cases and the necessity working length and the end of the canal. In the stain-
of using small instruments, the tip should not be less steel group, 6% of canals fell into this category. The
used to cut into or drill into the canal; it should act degree of destruction around the foramen was signifi-
only as a guide. Regardless of the technique being cantly different (p < .05). Apical zipping occurred
used, nickel-titanium instruments should be 31.7% less often with the Nitinol files.139 Stripping of
advanced in small increments with a more passive the canal walls was less with the nickel-titanium files. A
pressure than that used with stainless steel. second study in which the blocks were instrumented by
13. Do not get in a hurry! Do not get in a hurry! Do not a member of the faculty had similar findings.140
get greedy and try to make nickel titanium do more An observation from these studies was the creation
than it is designed to do. of a smooth belly shape on the outer aspect of the api-
14. Inspection of instruments, particularly used instru- cal third of the canals instrumented with nickel-titani-
ments, by staff and doctor is critical. Prior to inser- um instruments. This seemed to replace the ledging
tion and on removal, look at the blade. Rotate the file, that occurred with stainless steel. Other studies have
looking for deflections of light. This indicates a dam- shown that this may be attributable to the technique in
aged instrument. Also remember that, unlike stain- which the files were used.
less steel, nickel titanium has an excellent memory. Are nickel-titanium hand instruments best used with
The file should be straight. If any bend is present, the a push-pull filing motion or with a reaming or rotary
instrument is fatigued and should be replaced. motion? In one study, nickel-titanium files used in a fil-
15. Do not assume that the length of files is always accu- ing motion caused a significantly greater amount of the
rate; measure each file. Some files are longer from outer canal wall to be removed, between 3 and 6 mm
handle to tip than others. Files may also become short of working length. The stainless steel files, howev-
longer or shorter if they are unraveled or twisted. er, removed significantly more of the outer canal wall, at
working length and in the danger zone, than did the
Comparative Studies rotary or hand nickel-titanium files. The rotary nickel-
Nickel-titanium instruments function differently than titanium files were significantly faster and maintained
those made of stainless steel, even when the cross-sec- better canal shape than the other groups. The results of
tional design, taper, flutes, and tip are identical. In an this study indicate that nickel-titanium instruments
effort to compare hand nickel-titanium to stainless should be used with a rotational or reaming motion
steel files, a series of studies were initiated at The and are effective in shaping root canal systems.141
University of Tennessee. Eighty-two second-year dental Using computed tomography, Gambill et al.
students were required to instrument two epoxy blocks reamed extracted teeth with either stainless steel or
containing curved canals. The only variable was the use nickel-titanium files and reported that the nickel-tita-
of stainless steel files in one block and nickel-titanium nium files caused less canal transportation, removed
less dentin, were more efficient, and produced more International, Woodinville, Wash.), the Quantec ETM
centered canals.142 Electric torque control motor (Sybron-Endo; Irving,
On the other hand, not all studies are in agreement Calif.), and the Moyco/Union Broach Sprint EDM
concerning cutting efficiency. Tepel et al. tested 24 Electronic Digital Motor handpiece (Miller Dental;
brands of hand instruments specifically for cutting effi- Bethpage, N.Y.). These electric motors are specifically
ciency. They found that flexible stainless steel files were designed to power the new nickel-titanium instruments
more efficient than nickel titanium. However, they did in canal preparation. The speeds vary from 300 rpm sug-
not address the quality of the completed canal.143 gested for the NiTi ProFiles (Tulsa Dental; Tulsa, Okla.)to
Elliot et al., at Guys Hospital in London, used resin 2,000 rpm recommended for the LightSpeed instruments.
blocks to compare stainless steel (Flexofiles) and nick- Newer electric handpieces are available wherein not
el-titanium (Nitiflex) instruments used with either a only the speed can be controlled but the torque as well,
balanced force or stepback technique.144 The authors that is, the speed and torque can be set for a certain size
concluded that it is preferable to use nickel-titanium instrument and the handpiece will stall and reverse if
instruments in a balanced force technique and stainless the torque limit is exceeded. Emerging as contenders in
steel in a filing technique because stainless steel files can this field are the new Aseptico ITR Motor handpiece
be precurved. Considering the results from Tennessee (Aseptico International; Woodinville, Wash.), the Nouvag
and London, nickel-titanium instruments should be TCM ENDO motor (Nouvag, Switzerland), the new
used as reamers, not files. Endo-Pro Electric (Medidenta/MicroMega; Woodside,
N.Y.), and the new ProTorq motor handpiece (Micro
ISO Groups II and III Motors Inc; Santa Ana, Calif.).
Engine-driven instruments can be used in three types An entirely new wrinkle in rotary handpieces is the
of contra-angle handpieces: a full rotary handpiece, Morita Tri Auto-ZX (J. Morita USA Inc. Irvine, CA), a
either latch or friction grip, a reciprocating/quarter- cordless, battery-powered, endodontic, slow-speed (280
turn handpiece, or a special handpiece that imparts a rpm) handpiece with a built-in apex locator. It uses
vertical stroke but with an added reciprocating quarter- rotary nickel-titanium instruments held by a push-but-
turn that cuts in when the instrument is stressed. In ton chuck. The Tri Auto-ZX has three automatic func-
addition, there are battery-powered, slow-speed hand- tions: The handpiece automatically starts when the file
pieces that are combined with an apex locator, designed enters the canal and stops when the file is removed. If
to prevent apical perforations. Because the instruments too much pressure is applied, the handpiece automati-
used in these handpieces are generally designed for the cally stops and reverses rotation. It also automatically
type of action delivered, it is best to describe the hand- stops and reverses rotation when the file tip reaches the
piece before discussing their instruments. apical stop, as determined by the build-in apex locator.
Rotary Contra-angle Handpiece Instruments. The Tri Auto-ZX will work in a moist canal.
Instrumentation with a full rotary handpiece is by Reciprocating Handpiece. A commonly used flat
straight-line drilling or side cutting. Mounted with plane reciprocating handpiece is the Giromatic
round or tapered burs or diamond points, full rotary (Medidenta/MicroMega; Woodside, N.Y.). It accepts only
contra-angle handpieces can be used to develop coro- latch-type instruments. In this device, the quarter-turn
nal access to canal orifices. In addition, special reamers, motion is delivered 3,000 times per minute. More recent-
listed under ISO Group II, may be used to funnel out ly, Kerr has introduced the M4 Safety Handpiece (Sybron-
orifices for easier access, to clean and shape canals with Kerr; Orange, Calif.), which has a 30-degree reciprocating
slow-turning nickel-titanium reamer-type instru- motion and a unique chuck that locks regular hand files in
ments, and to prepare post channels for final restora- place by their handles (Figure 10-30). The Kerr Company
tion of the tooth. recommends that their Safety Hedstrom Instrument be
Since some of these instruments (stainless) do not used with the M4. Zakariasen et al. found the M4, mount-
readily bend, they should be used in perfectly straight ed with Safety Hedstrom files, to be somewhat superior to
canals. Because they are often misdirected or forced step-back hand preparations and a shorter time of prepa-
beyond their limits, they notoriously cause perfora- ration.145,146 German researchers found much the same
tions or break in the hands of neophytes. for both the M4 and the Giromatic.147
One solution to these problems is to use a slower hand- The Endo-Gripper (Moyco/Union Broach; Bethpage,
piece: the Medidenta/Micro Mega MM 324 reduction N.Y.) is a similar handpiece, with a 10:1 gear ratio and a
gear Handpieces (Medidenta/Micro Mega, Woodside, 45-degree turning motion. As with the Kerr M4, the
N.Y.), the Aseptico Electric Motor Handpiece (Aseptico Endo-Gripper also uses regular hand, not contra-angle,
time, all of the drills fractured near the shank, a major much in vogue. Although the K-style configuration is
departure from the previous test.158,159 still widely used, the rotary U-style (ProFile) and drill
The Peeso reamer (Dentsply/Maillefer; Tulsa, Okla.) style (Quantec) instruments are proving ever more
is most often used in preparing the coronal portion of popular. The use of these instruments will be described
the root canal for a post and core. One must be careful later in the chapter.
to use the safe-ended Peeso drill to prevent lateral
perforation. Gutta-percha should have previously been Ultrasonic and Sonic Handpieces
removed to post depth with a hot plugger. Round burs Instruments used in the handpieces that move near or
should never be used. faster than the speed of sound range from standard K-
The use of rotary instruments will be described in type files to special broach-like instruments.
the instrumentation section. If used correctly, they can Ultrasonic endodontics is based on a system in which
be a tremendous help in facilitating instrumentation. sound as an energy source (at 20 to 25 kH) activates
an endodontic file resulting in three-dimensional acti-
Rotary K-Type, U-Type, H-Type, vation of the file in the surrounding medium.160 The
and Drill-Type Instruments main dbriding action of ultrasonics was initially
As previously stated, the same instrument designs thought to be by cavitation, a process by which bubbles
described for hand instruments are available as rotary- formed from the action of the file, become unstable,
powered instruments. To think this a new idea, one has collapse, and cause a vacuum-like implosion. A com-
only to return to a year 1912 catalog to learn that rotary bined shock, shear and vacuum action results.160
instruments were being used nearly a century ago, K- Ultrasonic handpieces use K files as a canal instru-
style rotary broaches (reamers) made of carbon steel ment. Before a size 15 file can fully function, however,
(Figure 10-32). At that early time, the probability of the canal must be enlarged with hand instruments to at
their breakage was precluded by the very slow speed of least a size 20.
the treadle-type, foot-powered handpieces. Although Richman must be credited with the first use
Today, at speeds that vary from 300 to 2,500 rpm, (1957) of ultrasonics in endodontics,161 Martin and
and with the growing use of nickel-titanium instru- Cunningham were the first to develop a device, test it, and
ments, rotary canal preparation is once again very see it marketed in 1976.162171 Ultimately named the
Figure 10-32 Historical illustration of Kerr Engine Drills, circa 1912. The shape of the drills resembles present-day K-style reamers. Made
of carbon steel, they were probably safe to use in straight canals with a slow, treadle-type, foot-powered handpiece. (Courtesy of Kerr Dental
Manufacturing Co., 1912 catalog.)
Cavitron Endodontic System (Dentsply/Caulk; York, process.190192 They believe that a different physical
Pa.), (Figure 10-33), it was followed on the market by the phenomenon, acoustic streaming, is responsible for
Enac unit (Osada Electric Co., Los Angeles, Calif.) and the dbridement. They concluded that transient cavi-
the Piezon Master 400 (Electro Medical Systems, SA, tation does not play a role in canal cleaning with the
Switzerland), as well as a number of copycat devices. CaviEndo unit; however, acoustic streaming does
These instruments all deliver an irrigant/coolant, appear to be the main mechanism involved.190 They
usually sodium hypochlorite, into the canal space pointed out that acoustic streaming depends on free
while cleaning and shaping are carried out by a vibrat- displacement amplitude of the file and that the vibrat-
ing K file. ing file is dampened in its action by the restraining
The results achieved by the ultrasonic units have walls of the canal.
ranged from outstanding162183 to disappointing.184189 The Guys Hospital group found that the smaller files
Surely, there must be an explanation for such wide vari- generated greater acoustic streaming and hence much
ance in results. cleaner canals. After canals are fully prepared, by what-
The answer seems to lie in the extensive experimen- ever means, they recommended returning with a fully
tation on ultrasonic instruments carried out, principal- oscillating No. 15 file for 5 minutes with a free flow of
ly at Guys Hospital in London. They thoroughly stud- 1% sodium hypochlorite.191 In another study, the Guys
ied the mechanisms involved and questioned the role Hospital group found that root canals had to be
that cavitation and implosion play in the cleansing enlarged to the size of a No. 40 file to permit enough
A
Figure 10-33 A, CaviEndo unit with handpiece (right) and
reservoir hatch (top right). Dials (front panel) regulate vibratory
settings. Foot control not shown. B, CaviEndo handpiece mount-
ed with an Endosonic diamond file. Irrigating solution emits
through a jet in the head. (Courtesy of Dentsply/Cavitron.)
clearance for the free vibration of the No. 15 file at full (2.5%) for water, however, all of the bacteria were killed,
amplitude.192 Others, including Martin, the developer, proving once again the importance of using an irrigating
have recommended that the No. 15 file be used exclu- solution with bactericidal properties.197
sively.165,174,186 The efficacy of ultrasonography to thor- Ahmad and Pitt Ford also pitted one ultrasonic unit
oughly dbride canals following step-back preparation against the otherCaviEndo versus Enac.198 They
was dramatically demonstrated by an Ohio State/US evaluated canal shape and elbow formation: There was
Navy group. There was an enormous difference in no significant differencein the amount of apical
cleanliness between canals merely needle-irrigated dur- enlargement. They did find, however, that the Enac
ing preparation and those canals prepared and followed unit had a greater propensity for producing elbows, as
by 3 minutes of ultrasonic instrumentation with a No. well as apical deviation and change of width.198
15 file and 5.25% sodium hypochlorite.193 Ahmad, at Guys Hospital, suggested that the man-
Another British group reached similar conclusions ufacturers of ultrasonic units consider different file
about the oscillatory pattern of endosonic files.194 designs. She found the K-Flex to be more efficient than
These researchers pointed out that the greatest dis- the regular K style.199
placement amplitude occurs at the unconstrained tip
and that the greatest restraint occurs when the instru- Ultrasonic Conclusions
ment is negotiating the apical third of a curved canal. One can draw the conclusion that ultrasonic endodon-
This is the damping effect noted by the Guys Hospital tics has added to the practice of root canal therapy.
group, the lack of freedom for the tip to move freely to There is no question that canals are better dbrided if
either cut or cause acoustic streaming to cleanse.190 ultrasonic oscillation with sodium hypochlorite is
Krell at The University of Iowa observed the same phe- used at the conclusion of cavity preparation. But the
nomenon, that the irrigant could not advance to the files must be small and loose in the canal, particularly
apex until the file could freely vibrate.195 The British in curved canals, to achieve optimum cleansing.
researchers also reported better results if K files were
precurved when used in curved canals.196 Sonic Handpieces
At Guys Hospital, another interesting phenomenon The principal sonic endodontic handpiece available
was discovered about ultrasonic canal preparationthat, today is the Micro Mega 1500 (or 1400) Sonic Air Endo
contrary to earlier reports,170 ultrasonics alone actually System (Medidenta/ Micro Mega) (Figure 10-34). Like
increased the viable counts of bacteria in simulated root the air rotor handpiece, it attaches to the regular airline
canals.197 This was felt to be caused by the lack of cavita- at a pressure of 0.4 MPa. The air pressure may be var-
tion and the dispersal effects of the bacteria by acoustic ied with an adjustable ring on the handpiece to give an
streaming. On substitution of sodium hypochlorite oscillatory range of 1,500 to 3,000 cycles per second.
Tap water irrigant/coolant is delivered into the prepa- widened the canals more effectively than the Rispi
ration from the handpiece. Sonic files, whilst the Heliosonic [Trio Sonic] files were
Walmsley et al., in England, studied the oscillatory particularly ineffective202
pattern of sonically powered files. They found that out The research group at Temple University found
in the air, the sonic file oscillated in a large elliptical essentially the same results. They recommended that
motion at the tip. When loaded, as in a canal, however, the Shaper Sonic files be used first and that the remain-
they were pleased to find that the oscillatory motion ing two-thirds of the canal be finished with the Rispi
changed to a longitudinal motion, up and down, a Sonic.203 Ehrlich et al. compared canal apical transport
particularly efficient form of vibration for the prepara- using Rispi Sonic and Trio Sonic files versus hand
tion of root canals.200 instrumentation with K files.204 They found no differ-
The strength of the Micro Mega sonic handpiece lies ence in zipping among the three instruments. Even the
in the special canal instruments used and the ability to worst transport was only 0.5 mm. Tronstad and
control the air pressure and hence the oscillatory pattern. Niemczyk also tested the Rispi and Shaper files against
The three choices of file that are used with the Micro other instruments. They reported no complications
Mega 1500 are the RispiSonic, developed by Dr. Retano (broken instruments, perforations, etc) with either of
Spina in Italy, the Shaper Sonic (Medidenta; Woodside, the Sonic instruments.205 Miserendino et al. also found
N.Y.), developed by Dr. J. M. Laurichesse in France, and that the Micro Mega sonic vibratory systems using
the Trio Sonic (Medidenta; Woodside, N.Y.) (also called Rispi Sonic and Shaper files were significantly more
in Europe the Heliosonic and the Triocut File) (Figure efficient than the other systems tested.206
10-35). The Rispi Sonic resembles the old rat-tail file. The
ShaperSonic resembles a husky barbed broach. The Comparisons in Efficacy and Safety of Automated
TrioSonic resembles a triple-helix Hedstroem file. All of Canal Preparation Devices
these instruments have safe-ended noncutting tips. Before making an investment in an automated
The RispiSonic has 8 cutting blades and the Shaper endodontic device, one should know the comparative
Sonic has 16. The ISO sizes range from 15 to 40. values of the different systems and their instruments.
Because graduated-size instruments have varying shaft
sizes, the instrument must be tuned with the units tun-
ing ring to an optimum tip amplitude of 0.5 mm.
As with the ultrasonic canal preparation, these
instruments must be free to oscillate in the canal, to rasp
away at the walls, and to remove necrotic debris and
pulp remnants. To accommodate the smallest instru-
ment, a size 15, the canal must be enlarged to the work-
ing length with hand instruments through size No. 20.
The sonic instruments, with the 1.5 to 2.0 mm safe tips,
begin their rasping action this far removed from the
apical stop. This is known as the sonic length. As the
instrument becomes loose in the canal, the next-size
instrument is used, and then the next size, which devel-
ops a flaring preparation. The sonic instruments are
primarily for step-down enlarging, not penetration.
Cohen and Burns emphasized the three objectives of
shaping the root canal: (a) developing a continuous
tapering conical form; (b) making the canal narrow
apically with the narrowest cross-sectional diameter at
its terminus, and (c) leaving the apical foramen in its
original position spatially.201
To satisfy these requirements, two of the sonic
instruments have been quite successful. At the dental A B C
school in Wales, Dummer et al. found the Rispi Sonic Figure 10-35 Three instruments used with the MM1500 Sonic Air
and Shaper Sonic files to be the most successful, the handpiece. A, RispiSonic. B, ShaperSonic. C, TrioSonic (aka
Trio Sonic less so202: In general, the Shaper Sonic files Heliosonic or Triocut). (Courtesy of Medidenta/Micro Mega.)
Unfortunately, the ultimate device and instrument has at Iowa, found hand preparation with the step-back
not been produced and tested as yet. Some are better in technique superior to sonic and ultrasonic preparation
cutting efficiency, some in following narrow curved except in the important apical area, where they were
canals, some in producing smooth canals, and some in similar.211 The Iowa group also found that ultrasonic
irrigating and removing smear layer, but apparently and sonic files best cleaned ovoid canals.212
none in mechanically reducing bacterial content. Lev et al. prepared the cleanest canals using the
As stated above, Miserendino et al. found that the cut- step-back technique followed by 3-minute use of a
ting varied considerably. They ranked the RispiSonic file CaviEndo ultrasonic file with sodium hypochlorite.213
at the top, followed by the ShaperSonic, the Enac U file This approach has become an optimum and standard
(Osada Electric), and the CaviEndo K file.206 procedure for many endodontists.
Tronstad and Niemczyks comparative study favored Stamos et al. also compared cleanliness following
the Canal Finder System in narrow, curved canals. On ultrasonic dbridement with sodium hypochlorite or
the other hand, the Rispi and Shaper files in the Micro tap water. Using water alone, the Enac system was more
Mega Sonic handpiece proved the most efficacious in effective, but when sodium hypochlorite was used, the
all types of root canals. The Cavitron Endo System was CaviEndo unit (which has a built-in tank) was superi-
a disappointment in that it was so slow, blocked and or. They also reported ultrasonic preparation to be
ledged the canals, and fractured three files in severely significantly faster than hand instrumentation.214
curved canals. They also found the Giromatic with A US Army research group tested sonic versus ultra-
Rispi files to be effective in wide straight canals, less so sonic units and concluded that they were all effective in
in curved canals, where four Rispi files fractured.205 canal preparation but judged the Micro Mega Sonic Air
Bolanos et al. also tested the Giromatic with Rispi System, using Rispi and Shaper Sonic files, as the best
files against the Micro Mega Sonic handpiece with system tested.215
Rispi and Shaper files. They found the RispiSonic best Fairbourn et al. compared four techniques accord-
in straight canals, the ShaperSonic best in curved ing to the amount of debris extruded from the apex.
canals, and both better than the Giromatic/Rispi The sonic technique extruded the least and hand
and/or hand instrumentation with K-Flex files. The instrumentation the most debris. Ultrasonic was
Shaper files left the least debris and the Giromatic/Rispi halfway between.216 Whether the debris discharged
left an extensive amount of debris.203 into the apical tissue contains bacteria was of the
Kielt and Montgomery also tested the Micro Mega utmost importance. Using sterile saline as an irrigant,
Sonic unit with TrioSonic files against the ultrasonic Barnett et al. found sodium hypochlorite to be four
Cavitron Endo and Enac units with K files.207 Even times more effective than sterile saline.217 A US Navy
though others found the Trio Sonic files less effective group found essentially the same thing.218
(than the Rispi or Shaper files),204 Kielt and Comparative Conclusion of Automated Devices.
Montgomery concluded that overall the Medidenta It appears safe to say that no one automated device will
unit was superior to the other endosonic systems and answer all needs in canal cleaning and shaping. Hand
to the hand technique (control).207 The Zakariasen instrumentation is essential to prepare and cleanse the
group at Dalhousie University reported unusual suc- apical canal, no matter which device, sonic or ultrason-
cess in combining hand instrumentation with sonic ic, is used. The sonic unit Micro Mega 1500 reportedly
enlargements using the Micro Mega 1500.208 enlarges the canal the fastest when Rispi or Shaper files
Walker and del Rio also compared the efficacy of the are used, whereas the Canal Finder System, using
Cavitron Endo and Enac ultrasonic units against the A-style files, leads in instrumenting narrow curved
Micro Mega Sonic unit and found no statistically sig- canals. Finally, the ultrasonic CaviEndo and Enac units,
nificant difference among the groups, however, liquid using small K files and half-strength sodium hypochlo-
extruded from the apical foramen in 84% of their test rite for an extended time (3 minutes), seem to dbride
teeth. They felt that sodium hypochlorite may the canal best. No technique without sodium
improve the dbridement of the canal. They also did hypochlorite kills bacteria, however.
not test the Rispi or Shaper Sonic files.209 One must evaluate ones practice and decide which
At the University of Minnesota, the ultrasonic units device, no device, or all three best suit ones needs.
were again tested against the sonic unit. The researchers
found the Micro Mega Sonic to be the fastest in prepa- ISO Group IV Filling Materials
ration time and caused the least amount of straighten- An ADA specification has also been written for filling
ing of the canals.210 On the other hand, Reynolds et al., materialscore materials such as gutta-percha and sil-
ver points, as well as sealer cements classified by their A potential complication of irrigation is the forced
chemical make-up and mode of delivery. extrusion of the irrigant and debris through the apex. This
raises questions concerning the choice of irrigating solu-
IRRIGATION tion, the best method of delivering the irrigant, and the
Chemomechanical Dbridement volume of irrigant used. Other variables include how long
The pulp chamber and root canals of untreated nonvi- the solution is left in the canal, ultrasonic activation, tem-
tal teeth are filled with a gelatinous mass of necrotic perature of the irrigant, and the effect of combining dif-
pulp remnants and tissue fluid (Figure 10-36). Essential ferent types of solutions. Although the presence of an irri-
to endodontic success is the careful removal of these gant in the canal throughout instrumentation facilitates
remnants, microbes, and dentinal filings from the root the procedure, there are specific lubricating agents
canal system. The apical portion of the root canal is designed for that purpose: examples are RC Prep (Premier
especially important because of its relationship to the Dental; King of Prussia, Pa.), GlyOxide (Smith Kline
periradicular tissue. Although instrumentation of the Beecham, Pittsburgh, Pa.), REDTAC (Roth International,
root canal is the primary method of canal dbridement, Chicago, Ill.), and Glyde File Prep (Dentsply/Maillefer;
irrigation is a critical adjunct. Irregularities in canal sys- Tulsa, Okla.). It is highly recommended that canals always
tems such as narrow isthmi and apical deltas prevent be instrumented while containing an irrigant and/or a
complete dbridement by mechanical instrumentation lubricating agent. Instrumentation in this manner may
alone. Irrigation serves as a physical flush to remove prevent the complication of losing contact with the meas-
debris as well as serving as a bactericidal agent, tissue urement control owing to an accumulation of debris in
solvent, and lubricant. Furthermore, some irrigants are the apical segment of the canal.
effective in eliminating the smear layer.
Root Canal Irrigants
A wide variety of irrigating agents are available. It is
recommended that the practitioner understands the
potential advantages and disadvantages of the agent to
be used.
Sodium Hypochlorite. Sodium hypochlorite is
one of the most widely used irrigating solutions.
Household bleach such as Chlorox contains 5.25%
sodium hypochlorite. Some suggest that it be used at
that concentration, whereas others suggest diluting it
with water, and still others alternate it with other
agents, such as ethylenediaminetetraacetic acid with
centrimide (EDTAC) (Roydent Products; Rochester
Hills, Mich.) or chlorhexidine (Proctor & Gamble,
Cincinnati, Ohio). Sodium hypochlorite is an effective
antimicrobial agent, serves as a lubricant during instru-
mentation, and dissolves vital and nonvital tissue.
Questions concerning the use of sodium hypochlorite
are often focused on the appropriate concentration,
method of delivery, and concern with cellular damage
caused by extrusion into the periradicular tissues.
Researchers do not agree on the precise concentration
of sodium hypochlorite that is advisable to use.
Baumgartner and Cuenin, in an in vitro study, found
that 5.25%, 2.5%, and 1.0% solutions of sodium
hypochlorite completely removed pulpal remnants and
predentin from uninstrumented surfaces of single-canal
premolars.219 Although 0.5% sodium hypochlorite
Figure 10-36 Gelatinous mass of necrotic debris should be elimi-
nated from the pulp canal before instrumentation is started. removed most of the pulpal remnants and predentin
Forcing this noxious infected material through the apical foramen from uninstrumented surfaces, it left some fibrils on the
might lead to an acute apical abscess. surface. They commented that It seemed probable that
there would be a greater amount of organic residue study, 3% sodium hypochlorite was found to be optimal
present following irrigation of longer, narrower, more for dissolving tissue fixed with parachlorophenol or
convoluted root canals that impede the delivery of the formaldehyde.226 Clearly, the final word has not been
irrigant. This concern seems reasonable as the ability of written on this subject.
an irrigant to be distributed to the apical portion of a Sodium Hypochlorite Used in Combination with
canal is dependent on canal anatomy, size of instru- Other Medicaments. Whether sodium hypochlorite
mentation, and delivery system. Trepagnier et al. report- should be used alone or in combination with other
ed that either 5.25% or 2.5% sodium hypochlorite has agents is also a source of controversy. There is increas-
the same effect when used in the root canal space for a ing evidence that the efficacy of sodium hypochlorite,
period of 5 minutes.220 as an antibacterial agent, is increased when it is used in
Spngberg et al. noted that 5% sodium hypochlorite combination with other solutions, such as calcium
may be too toxic for routine use.221 They found that hydroxide, EDTAC, or chlorhexidine. Hasselgren et al.
0.5% sodium hypochlorite solution dissolves necrotic found that pretreatment of tissue with calcium
but not vital tissue and has considerably less toxicity for hydroxide can enhance the tissue-dissolving effect of
HeLa cells than a 5% solution. They suggested that sodium hypochlorite.227
0.5% sodium hypochlorite be used in endodontic ther- Wadachi et al., using 38 bovine freshly extracted
apy. Bystrom and Sundquist examined the bacteriolog- teeth, studied the effect of calcium hydroxide on the
ic effect of 0.5% sodium hypochlorite solution in dissolution of soft tissue on the root canal wall.228 They
endodontic therapy.222 In that in vivo study, using 0.5% found that the combination of calcium hydroxide and
sodium hypochlorite, no bacteria could be recovered sodium hypochlorite was more effective than using
from 12 of 15 root canals at the fifth appointment. This either medicament alone.
was compared with 8 of 15 root canals when saline However, Yang et al., using 81 freshly extracted human
solution was used as the irrigant. Baumgartner and molars, examined the cleanliness of main canals and
Cuenin also commented that The effectiveness of low inaccessible areas (isthmi and fins) at the apical, middle,
concentrations of NaOCl may be improved by using and coronal thirds.229 Complete chemomechanical
larger volumes of irrigant or by the presence of replen- instrumentation combined with 2.5% sodium hypochlo-
ished irrigant in the canals for longer periods of rite irrigation alone accounted for the removal of most
time.219 On the other hand, a higher concentration of tissue remnants in the main canal. Prolonged contact
sodium hypochlorite might be equally effective in with calcium hydroxide to aid in dissolving main canal
shorter periods of time. tissue remnants after complete instrumentation was inef-
Siqueira et al., in an in vitro study, evaluated the effect fective. They also found that tissues in inaccessible areas
of endodontic irrigants against four black-pigmented (isthmi and fins) of root canals were not contacted by cal-
gram-negative anaerobes and four facultative anaerobic cium hydroxide or sodium hypochlorite and were poorly
bacteria by means of an agar diffusion test. A 4% sodi- dbrided. As they noted, however, it could be that their
um hypochlorite solution provided the largest average study did not permit sufficient time (1 day or 7 days) for
zone of bacterial inhibition and was significantly supe- the tissue to be degraded. Hasselgren et al. reported that
rior when compared with the other solutions, except porcine muscle was completely dissolved after 12 days of
2.5% sodium hypochlorite (p < .05). Based on the aver- exposure to calcium hydroxide.227 The contrasting results
ages of the diameters of the zones of bacterial growth of some investigators may be explained by their different
inhibition, the antibacterial effects of the solution were methodologies including varied tissues studied, as well as
ranked from strongest to weakest as follows: 4% sodium a variety of delivery systems and the vehicle included in
hypochlorite; 2.5% sodium hypochlorite; 2% chlorhex- the calcium hydroxide mix.
idine, 0.2% chlorhexidine EDTA, and citric acid; and Other variables to be considered include temperature
0.5% sodium hypochlorite.223 as well as shelf life of the solution.230232 Raphael et al.
The question of whether sodium hypochlorite is tested 5.25% sodium hypochlorite on Streptococcus fae-
equally effective in dissolving vital, nonvital, or fixed tis- calis, Staphylococcus aureus, and Pseudomonas aerugi-
sue is important since all three types of tissue may be nosa at 21C and 37C and found that increasing the
encountered in the root canal system. Rosenfeld et al. temperature made no difference on antimicrobial effi-
demonstrated that 5.25% sodium hypochlorite dis- cacy and may even have decreased it.233 Pseudomonas
solves vital tissue.224 In addition, as a necrotic tissue sol- aeruginosa was particularly difficult to eliminate. Buttler
vent, 5.25% sodium hypochlorite was found to be sig- and Crawford, using Escherichia coli and Salmonella
nificantly better than 2.6%, 1%, or 0.5%.225 In another typhosa, studied 0.58%, 2.7%, and 5.20% sodium
A B
Figure 10-37 A, Coronal portion of a root canal of a tooth treated in vivo with Salvizol. The canal wall is clean, and very small pulpal tis-
sue remnants are present; the tubules are open, and many intertubular connections with small side branches are visible. B, Middle portion
of root canal treated with Salvizol. Note the tridimensional framework arrangement of tubular openings. Very little tissue debris is present.
Intratubular connections are clearly seen. Reproduced with permission from Kaufman AY et al.239
ly effective on initial exposure, it is not a substantive canals of their filings, debris, and bacteria, all the way to
antimicrobial agent. the apex, has been well documented by Cunningham et
Kaufman reported the success of several cases using al.168,169 as well as others. More recently, they have been
bis-dequalinium acetate (BDA) as a disinfectant and joined by a number of clinicians reporting favorable
chemotherapeutic agent247 He cited its low toxicity, results with ultrasonic/sonic irrigation, from thorough-
lubrication action, disinfecting ability, and low surface ly cleansing the walls in necrotic open apex cases, 252 to
tension, as well as its chelating properties and low inci- removing the smear layer.253 Griffiths and Stock pre-
dence of post-treatment pain. ferred half-strength sodium hypochlorite to Solvidont
Others have pointed out the efficacy of BDA. In one in dbriding canals with ultrasound.254 Sjgren and
report, it was rated superior to sodium hypochlorite in Sundqvist found that ultrasonography was best in elim-
dbriding the apical third.248 When marketed as inating canal bacteria but still recommended the use of
Solvidont (Dentsply/DeTrey, Switzerland), the an antibacterial dressing between appointments.255
University of Malaysia reported a remarkable decrease Others were not as impressed.256,257 In fact, one
in postoperative pain and swelling when BDA was used. group found sodium hypochlorite somewhat better
They attributed these results to the chelation properties than tap water when used with ultrasonography but
of BDA in removing the smear layer coated with bacte- also noted that both irrigants were ineffective in
ria and contaminants as well as the surfactant properties removing soft tissue from the main canal, the isthmus
that allow BDA to penetrate into areas inaccessible to between canals, the canal fins, and the multiple
instruments.249 Bis-dequalinium acetate is recom- branches or deltas.252 However, they used ultrasonics
mended as an excellent substitute for sodium hypochlo- for only 3 minutes with a No. 15 file and 1 minute
rite in those patients who are allergic to the latter. with a No. 25 diamond file.252 As Druttman and Stock
Outside North America, it enjoys widespread use. pointed out, with the ultrasonic method, results
A Loyola University in vitro study reported that full- depended on irrigation time.258 As previously noted,
strength Clorox (sodium hypochlorite) and Gly-Oxide the cleanest canals are achieved by irrigating with
(urea peroxide), used alternately, were 100% effective ultrasonics and sodium hypochlorite for 3 minutes
against Bacteroides melaninogenicus, which has been after the canal has been totally prepared (Figure 10-
implicated as an endodontic pathogen. Alternating 38). Moreover, ultrasonics proved superior to syringe
solutions of sodium hypochlorite and hydrogen perox- irrigation alone when the canal narrowed to 0.3 mm
ide cause a foaming action in the canal through the (size 30 instrument) or less.259 Buchanan noted that it
release of nascent oxygen. Hydrogen peroxide (3%) is the irrigants alone that clean out the accessory
alone also effectively bubbles out debris and mildly canal. Instruments cannot reach back into these pas-
disinfects the canal. In contrast, Harrison et al. have sages. Only the copious use of a tissue-dissolving irri-
shown that using equal amounts of 3% hydrogen per- gant left in place for 5 to 10 minutes repeatedly will
oxide and 5.25% sodium hypochlorite inhibited the ensure auxiliary canal cleaning.260
antibacterial action of the irrigants.250 Because of the
potential for gaseous pressure from residual hydrogen
peroxide, it must always be neutralized by the sodium
hypochlorite and not sealed in the canal.
It must be understood that each of the studies cited
above has examined limited test results concerning the
use of various irrigants or combinations of irrigants.
However, there are other factors aside from the solution
used. For example, Ram pointed out that the irriga-
tional removal of root canal debris seems to be more
closely related to canal diameter than to the type of
solution used.251 This, in turn, must be related to the
viscosity or surface tension of the solution, the diame-
ter and depth of penetration of the irrigating needle,
the volume of the solution used, and the anatomy of
the canal. Figure 10-38 Irrigating solution climbs the shaft of a CaviEndo
Ultrasonic Irrigation. As stated previously, the use vibrating No. 15 file to agitate and dbride unreachable spaces in
of ultrasonic or sonic irrigation to better cleanse root the canal. (Courtesy of Dentsply/Cavitron.)
A B
C D
Figure 10-41 A, Canal wall untreated by acid. Note granular material and obstructed tubuli. B, Midroot canal wall treated with citric acid.
The surface is generally free of debris. C, Midroot canal wall cleaned with phosphoric acid, showing an exceptionally clean regular surface.
D, Apical area of root canal etched by phosphoric acid, revealing lateral canals. Reproduced with permission from Tidmarsh BG.268
Other organic acids have been used to remove the Therapeutics Hd, Sweden), quaternary ammonium
smear layer: polyacrylic acid as Durelon and Fuju II liq- bromide, used to reduce surface tension and increase
uids, both 40% polyacrylic acid.273 penetration.275 The optimal pH for the demineralizing
Chelating Agents. The most common chelating efficacy of EDTA on dentin was shown by Valdrighi to
solutions used for irrigation include Tublicid, EDTA, be between 5.0 and 6.0.276
EDTAC, File-Eze, and RC Prep, in all of which EDTA is Goldberg and Abramovich have shown that EDTAC
the active ingredient. Nygaard-stby first suggested the increases permeability into dentinal tubules, accessory
use of EDTA for cleaning and widening canals.274 Later, canals, and apical foramina277 (Figure 10-42).
Fehr and Nygaard-stby introduced EDTAC (N-O McComb and Smith found that EDTA (in its commer-
Figure 10-47 Step-down preparation. Necessity of maintaining control over burs and endodontic instruments in following out advanced
pulpal recession. A, Coronal cavity is enlarged sufficiently to accommodate the shaft of a No. 4 surgical-length bur that must function with-
out touching the cavity walls. B, Freely operating the No. 4 surgical-length bur following out receded pulp. C, A No. 2 surgical-length bur
used in depths of preparation. Repeated radiographs may be necessary to judge the progress of the instrument. D, Fine root canal instru-
ment used to explore and finally enlarge the patent portion of the canal.
below the floor of the pulp chamber into a e. Mandibular incisors frequently have two canals.
mesiobuccal and a mesiolingual canal. The lingual canal is hidden beneath the internal
c. Mandibular first and second molars may have shoulder that corresponds to the lingual cin-
two distal canals, with either separate orifices, or gulum. This shoulder prominence must be
a common orifice as described for the mesial. removed with a No. 2 long-shank round bur or
d. Mandibular first premolars frequently have a a fine tapered diamond stone to permit prop-
second canal branching off the main canal to the er exploration.
buccal or lingual, several millimeters below the
pulp chamber floor. In summary, the unexpected should always be
anticipated, and the operator must be prepared to
expand the access cavity for convenience in enlarging
one of these canals or even just to increase visual exam-
ination of the pulp chamber floor in searching for such
anatomic variance.
EXPLORATION OF THE CANAL
Besides the use of radiographs, the use of a fine curved
reamer or file is a method available to determine cur-
vature in canals. Stainless steel instruments are better
suited for this purpose. The superelastic properties of
nickel titanium, which make them desirous during the
cleaning and shaping phase, are not helpful in the
smaller sizes (6, 8, 10) when used for pathfinding.
Many times, however, it cannot be determined that the
canal is curved until enlargement begins and resistance
Figure 10-48 Two canals in the mesial root are clearly discernible develops to instrument placement above the No. 25 or
by radiograph (arrows). Both canals apparently have separate api- No. 30 file owing to a lack of file flexibility. This will be
cal foramina. (Courtesy of Dr. James D. Zidell.) discussed later in the chapter.
Figure 10-52 A, Working length film, mandibular premolar. The patient experienced sensitivity even though the instrument appears
approximately 3 mm short of the radiographic apex. B, Preoperative mesio-angled radiograph of the same tooth showing canal curvature
and the labial exit of the foramen (arrow) not evident on the working length film. (Courtesy of Dr. Thomas P. Mullaney.)
0.5 to 1.0 mm short of the radiographic apex, but with space short of the apical constriction. Such leakage
variations. Problems exist in locating apical landmarks supports the continued existence of viable bacteria and
and in interpreting their positions on radiographs. contributes to a continued periradicular lesion and
lowered rate of success.
Clinical Considerations In this era of improved illumination and magnifica-
Before determining a definitive working length, the coro- tion, working length determination should be to the
nal access to the pulp chamber must provide a straight- nearest one-half millimeter. The measurement should be
line pathway into the canal orifice. Modifications in made from a secure reference point on the crown, in close
access preparation may be required to permit the instru- proximity to the straight-line path of the instrument, a
ment to penetrate, unimpeded, to the apical constriction. point that can be identified and monitored accurately.
As stated above, a small stainless steel K file facilitates the Stop Attachments. A variety of stop attachments
process and the exploration of the canal. are available. Among the least expensive and simplest
Loss of working length during cleaning and shaping to use are silicone rubber stops. Several brands of
can be a frustrating procedural error. Once the apical instruments are now supplied with the stop attach-
restriction is established, it is extremely important to ments already in place on the shaft. Special tear-shaped
monitor the working length periodically since the or marked rubber stops can be positioned to align with
working length may change as a curved canal is the direction of the curve placed in a precurved stain-
straightened (a straight line is the shortest distance less steel instrument.
between two points).314,315 The loss may also be relat- The length adjustment of the stop attachments
ed to the accumulation of dentinal and pulpal debris in should be made against the edge of a sterile metric ruler
the apical 2 to 3 mm of the canal or other factors such or a gauge made specifically for endodontics. Devices
as failing to maintain foramen patency,316 skipping have been developed that assist in adjusting rubber
instrument sizes, or failing to irrigate the apical one- stops on instruments326 (Figure 10-55). It is critical that
third adequately. Occasionally, working length is lost the stop attachment be perpendicular and not oblique
owing to ledge formation or to instrument separation to the shaft of the instrument (Figure 10-56).
and blockage of the canal. There are several disadvantages to using rubber
Two in vivo studies measured the effect of canal stops. Not only is it time consuming, but rubber stops
preparation on working length.314316 The mean short- may move up or down the shaft, which may lead to
ening of all canals in these studies was found to range preparations short or past the apical constriction.
from 0.40 mm to 0.63 mm. The clinician should develop a mental image of the
There has been debate as to the optimal length of position of the rubber stop on the instrument shaft in
canal preparation and the optimal level of canal obtu- relation to the base of the handle. Any movement from
ration.317 Most dentists agree that the desired end that position should be immediately detected and cor-
point is the apical constriction, which is not only the rected. One should also develop a habit of looking
narrowest part of the canal318 but a morphologic land- directly at the rubber stop where it meets the reference
mark299,302 that can help to improve the apical seal
when the canal is obturated.319321
Failure to accurately determine and maintain work-
ing length may result in the length being too long and
may lead to perforation through the apical constric-
tion. Destruction of the constriction may lead to over-
filling or overextension and an increased incidence of
postoperative pain. In addition, one might expect a
prolonged healing period and lower success rate owing
to incomplete regeneration of cementum, periodontal
ligament, and alveolar bone.322325
Failure to determine and maintain working length
accurately may also lead to shaping and cleaning short
Figure 10-55 Guldener Endo-M-Bloc has 32 depth guides in two
of the apical constriction. Incomplete cleaning and rows. Front row indicators from 10 to 30 mm in 1 mm increments.
underfilling may cause persistent discomfort, often Back row indicators are 0.5 mm deeper. Helpful ruler at end. The
associated with an incomplete apical seal. Also, apical device is invaluable in step-back or step-down techniques.
leakage may occur into the uncleaned and unfilled (Courtesy of Dentsply/Maillefer).
Figure 10-58 A, Initial measurement. The tooth is measured on a good preoperative radiograph using the long cone technique. In this case,
the tooth appears to be 23 mm long on the radiograph. B, Tentative working length. As a safety factor, allowing for image distortion or mag-
nification, subtract at least 1 mm from the initial measurement for a tentative working length of 22 mm. The instrument is set with a stop at
this length. C, Final working length. The instrument is inserted into the tooth to this length and a radiograph is taken. Radiograph shows
that the image of the instrument appears to be 1.5 mm from the radiographic end of the root. This is added to the tentative working length,
giving a total length of 23.5 mm. From this, subtract 1.0 mm as adjustment for apical termination short of the cementodentinal junction (see
Anatomic Considerations). The final working length is 22.5 mm. D, Setting instruments. The final working length of 22.5 mm is used to set
stops on instruments used to enlarge the root canal.
Figure 10-59 Weines recommendations for determining working length based on radiographic evidence of root/bone resorption. A, If no
root or bone resorption is evident, preparation should terminate 1.0 mm from the apical foramen. B, If bone resorption is apparent but there
is no root resorption, shorten the length by 1.5 mm. C, If both root and bone resorption are apparent, shorten the length by 2.0 mm.
(Courtesy of Dr. Franklin Weine.)
instrument in place. A preferable method is to expose canal frequently constricts (minor diameter) before
the radiograph from a mesial-horizontal angle. This exiting the root. There is also a tendency for the canal
causes the lingual canal to always be the more mesial to deviate from the radiographic apex in this
one in the image (MLM, Clarks rule) or, alternatively, region.299,301,302,339,356
MBDwhen the x-ray beam is directed from the Seidberg et al. reported an accuracy of just 64%
Mesial, the Buccal canal is projected toward the Distal using digital tactile sense.296 Another in vivo study
on the film. found that the exact position of the apical constriction
When a mandibular molar appears to have two could be located accurately by tactile sense in only 25%
mesial roots or apices of different lengths or positions, of canals in their study.357
two mesial instruments can be used, and again the If the canals were preflared, it was possible for an
tooth can be examined radiographically from the expert to detect the apical constriction in about 75% of
mesial and Clarks or Ingles rule (MLM or MBD) the cases.358 If the canals were not preflared, determi-
applied. nation of the apical constriction by tactile sensation
Accuracy. Just how accurate is this radiographic was possible in only about one-third of the cases.359
measurement method? For one thing, accuracy All clinicians should be aware that this method, by
depends on the radiographic technique used. Forsberg, itself, is often inexact. It is ineffective in root canals
in Norway, demonstrated that paralleling technique with an immature apex and is highly inaccurate if the
was significantly more reliable than the canal is constricted throughout its entire length or if
bisecting-angle technique.333 A US Army group, how- the canal has excessive curvature. This method should
ever, found that the paralleling technique was absolute- be considered as supplementary to high-quality, care-
ly accurate only 82% of the time.334 Von der Lehr and fully aligned, parallel, working length radiographs
Marsh were accurate in anterior teeth 89% of the and/or an apex locator.
time.335 Paralleling still magnifies actual tooth length A survey found that few general practice dentists
by 5.4%.331 and no endodontists trust the digital tactile sense
As Olson et al. pointed out, 82 to 89% accuracy is method of determining working length by itself.360
not 100%, so they recommended back-up methods Even the most experienced specialist would be prudent
such as tactile feel, moisture on the tip of a paper point, to use two or more methods to determine accurate
or electronic apex locators.334 Similar results and rec- working lengths in every canal.
ommendations have been reported worldwide.336341 A
British group, for example, recommended the use of Determination of Working Length by Apical
radiovisiography with image enhancement to improve Periodontal Sensitivity
the quality of length-of-tooth radiographs.341 Any method of working length determination, based
on the patients response to pain, does not meet the
Accuracy of Working Length Estimation by Direct ideal method of determining working length. Working
Digital Radiography or Xeroradiography length determination should be painless. Endodontic
Several studies have evaluated the advantages of using therapy has gained a notorious reputation for being
direct digital radiography or xeroradiography for the painful, and it is incumbent on dentists to avoid per-
estimation of working length.342355 petuating the fear of endodontics by inserting an
The results of the studies indicate that there is no endodontic instrument and using the patients pain
statistically significant difference in working length reaction to determine working length.
estimation accuracy between conventional film, direct If an instrument is advanced in the canal toward
digital radiography, and xeroradiography. On the other inflamed tissue, the hydrostatic pressure developed
hand, rapid imaging and reduction in radiation by inside the canal may cause moderate to severe, instan-
these techniques represent a significant advancement taneous pain. At the onset of the pain, the instrument
in dental radiography (see Chapter 9). tip may still be several millimeters short of the apical
constriction. When pain is inflicted in this manner, lit-
Determination of Working Length by tle useful information is gained by the clinician, and
Digital Tactile Sense considerable damage is done to the patients trust.
If the coronal portion of the canal is not constrict- When the canal contents are totally necrotic, howev-
ed, an experienced clinician may detect an increase in er, the passage of an instrument into the canal and past
resistance as the file approaches the apical 2 to 3 mm. the apical constriction may evoke only a mild awareness
This detection is by tactile sense. In this region, the or possibly no reaction at all. The latter is common
A
Figure 10-61 A, Typical circuit for electronic determination of working
length. Current flows from Electronic apex locator (EAL) to the file, to the
cementoenamel junction and back to the EAL, where the position of the tips
is illustrated. The circuit is completed through lip attachment. B, The apical
foramen some distance from the radiographic apex stresses the importance
of finding the actual orifice by EAL. D = dentin; C = cementum. A courtesy
of Dr. Stephen Weeks. B reproduced with permission from Skillen WG. J Am
Dent Assoc 1930;17:2082. B
There is evidence that electronic devices measure mainly used, the studies might be improved by prior shaping
the impedance of the probing electrode (contact imped- and cleaning of the canal followed by multiple elec-
ance with the tissue fluid) rather than tissue impedance tronic working length determinations.
itself. Huang reported that the principle of electronic root In in vivo comparative studies in which the electron-
canal measurement can be explained by physical princi- ic file tip to apical constriction is also assessed by radi-
ples of electricity alone.389 Ushiyama and colleagues pre- ographs, the validity of the results is open to question.
sented this as the voltage gradient method that could The comparisons are only as accurate as the accuracy of
accurately measure working length in root canals filled the radiographic method of estimating working length.
with electrolyte.381383 A major disadvantage with this Current information places this accuracy in the 39 to
method was that it used a special bipolar electrode that 86% range.301,340,356,365,395398
was too large to pass into narrow root canals. Using cadavers, Pratten and McDonald compared
Experimental Design and Parameters of Accuracy the accuracy of three parallel radiographs of each canal
Studies. In vitro accuracy studies may be conducted at three horizontal angles with the accuracy of the
on models using an extracted tooth in an electrolyte to Endex apex locator.399 Even in these ideal conditions,
simulate clinical conditions.366,368370,390394 The ideal radiographic estimation was no more accurate than
conditions in in vitro testing may give accuracy results electronic determination.
higher than those obtainable in clinical practice. Another important point in accuracy studies is the
Alternatively, in the fabrication of the in vitro model, error tolerance that is accepted in the experimental
electrolyte may be inadvertently forced into the canal design. There appears to be a growing concern that either
space and give rise to an inaccuracy. a +0.5 error or a 0.5 error may give rise to clinical prob-
In vivo accuracy studies more closely reflect the real- lems and that the 0.5 tolerance may be unacceptable.400
ity of conditions in clinical practice. The best studies It would be useful clinically to use the apical con-
are those that use an apex locator to determine the striction as the ideal apical reference point in the canal
working length of a canal followed by locking the rather than the apical foramen.401,402 Consideration
measuring instrument at the electronic length. The should also be given to using 0.5 to 0.0 mm as the
tooth is extracted, and the exact relationship between most clinically ideal error tolerance.
the electronic length and the apical constriction is Classification and Accuracy of Apex Locators.
determined. Unfortunately, this design is not a viable The classification of apex locators presented here is a
alternative in most studies. Even when the design is modification of the classification presented by
McDonald.403 This classification is based on the type of The Digipex (Mada Equipment Co., Carlstadt, N.J.)
current flow and the opposition to the current flow, as has a visual LED digital indicator and an audible indi-
well as the number of frequencies involved. cator.404 It requires calibration. The Digipex II is a
First-Generation Apex Locators. First-generation combination apex locator and pulp vitality tester.
apex location devices, also known as resistance apex The Exact-A-Pex (Ellman International, Hewlett,
locators,403 measure opposition to the flow of direct cur- N.Y.) has an LED bar graph display and an audio indi-
rent or resistance. When the tip of the reamer reaches the cator.404 An in vivo study reported an accuracy of 55%
apex in the canal, the resistance value is 6.5 kilo-ohms ( 0.5 mm from the apical foramen).
(current 40 mA). Although it had some problems, the The Foramatron IV (Parkell Dental, Farmingdale,
original device was reported to be most accurate in N.Y.) has a flashing LED light and a digital LED display
palatal canals of maxillary molars and premolars.295 and does not require calibration. Two in vivo studies
Initially, the Sono-Explorer (Satalec, Inc, Mount Laurel, were reported on the Foramatron IV (Figure 10-
N.J.) was imported from Japan by Amadent. Today, most 62).408,409 Electronic determinations in one study were
first-generation apex location devices are off the market. found to be accurate ( 0.5 mm from the radiographic
Second-Generation Apex Locators. Second-genera- apex) in 65% of the cases.408 In the other study, 32% of
tion apex locators, also known as impedance apex loca- the cases were coincident with the radiographic apex
tors,403 measure opposition to the flow of alternating and 36% were short.409 None were long. This device is
current or impedance. Inoue developed the Sono- small, lightweight, and inexpensive.
Explorer,377380 one of the earliest of the second-gener- The Pio (Denterials Ltd., St. Louis, Mo.) apex loca-
ation apex locators. Several other second-generation tor has an analog meter display and an audio indicator.
apex locators then became available, including a num- It has an adjusting knob for calibration.
ber of improvements in the Sono-Explorer. Third-Generation Apex Locators. The principle on
The major disadvantage of second-generation apex which third-generation apex locators are based
locators is that the root canal has to be reasonably free of requires a short introduction. In biologic settings, the
electroconductive materials to obtain accurate readings. reactive component facilitates the flow of alternating
The presence of tissue and electroconductive irrigants in current, more for higher than for lower frequencies.
the canal changes the electrical characteristics and leads Thus, a tissue through which two alternating currents
to inaccurate, usually shorter measurements.390 This cre- of differing frequencies are flowing will impede the
ated a catch-22 situation. Should canals be cleaned and lower-frequency current more than the higher-fre-
dried to measure working length, or should working quency current. The reactive component of the circuit
length be measured to clean and dry canals?404 may change, for example, as the position of a file
There is another issue: not all apex locators incorpo- changes in a canal. When this occurs, the impedances
rate the same degree of sophistication in electronic cir- offered by the circuit to currents of differing frequen-
cuitry that adjusts its sensitivity to compensate for the cies will change relative to each other. This is the prin-
intracanal environment405 or indicates on its display ciple on which the operation of the third-generation
that it should be switched from a wet to a dry mode apex locators is based (SM Weeks, personal communi-
or vice versa. Pilot and Pitts reported that 5.25% sodi- cation, 1999).
um hypochlorite solution, 14.45% EDTA solution, and Since the impedance of a given circuit may be sub-
normal saline were conductive, whereas RC Prep and stantially influenced by the frequency of the current
isopropyl alcohol were not.406 flow, these devices have been called frequency
The Apex Finder (Sybron Endo/Analytic; Orange, dependent (SM Weeks, personal communication,
Calif.) has a visual digital LED indicator and is self-cal- 1999). Since it is impedance, not frequency, that is
ibrating. The Endo Analyzer (Analytic/Endo; Orange, measured by these devices, and since the relative mag-
Calif.) is a combined apex locator and pulp tester. The nitudes of the impedances are converted into length
Apex Finder has been subjected to several in vivo stud- information, the term comparative impedance may
ies.365,397,407,408 Compared to radiographic working be more appropriate (SM Weeks, personal communica-
length estimations, one study placed the accuracy at tion, 1999).
67% ( 0.5 mm from the radiographic apex).365 In a Endex (Osada Electric Co., Los Angeles, Calif. and
study in which Apex Finder working length determina- Japan), the original third-generation apex locator, was
tions were compared with direct anatomic working described by Yamaoka et al.410 (Figure 10-63). In
length measurements, only 20% of the determinations Europe and Asia, this device is available as the APIT. It
were coincident, and 53% were short.397 uses a very low alternating current.411 The signals of
Figure 10-62 Modern electrical apex locator that displays A, by digital readout, distance of the file tip to the cementodentinal junction in
tenths of millimeters; B, O reading, flashing red light, and pulsing tone when the cementodentinal junction is reached. C, If the apical con-
striction is penetrated, a yellow warning light flashes, a visual E (error) is displayed, and an audio alarm warns the dentist. (Courtesy of
Formatron/Parkell Products, Inc., Farmingdale, N.Y.)
two frequencies (5 and 1 kHz) are applied as a com- ference in impedance values begins to change. As the
posite waveform of both frequencies. As the attached apical constriction is reached, the impedance values are
endodontic reamer enters the coronal part of the canal, at their maximum difference, and these differences are
the difference in the impedances at the two frequencies indicated on the analog meter and audio alarm. This
is small. As the instrument is advanced apically, the dif- impedance difference is the basis of the difference
method.380 The unit must then be reset (calibrated)
for each canal.
The device operates most accurately when the canal
is filled with electrolyte (ie, normal saline or sodium
hypochlorite). Gutta-percha must be removed from the
canals in re-treatment cases before electronic working
length determination is made with this device. The
manufacturer indicates that the size of the endodontic
instrument does not affect the measurement.411
The Endex has been the subject of several accuracy
studies.358,364,397,399,412420 One in vitro study reported
that the Endex was superior to second-generation
devices when there was conductive fluid in the canals
and when the apical foramen was widened.413 Other in
vitro studies compared the Endex electronic working
length determination with direct anatomic working
length measurement. One study reported an accuracy
Figure 10-63 Endex (aka APIT), the original third-generation
of 96.5% (0.5 to 0.0 mm from the apical foramen).414
apex locator. It measures the impedance between two currents and
works in a wet canal with sodium hypochlorite. (Courtesy of Another study reported an accuracy of 85% ( 0.5 mm
Osada Electric Co.) from the apical foramen).358
The Pratten and McDonald in vitro study of teeth in Two electric potentials are obtained that correspond to
human cadavers compared Endex determinations to two impedances of the root canal. These two potentials
radiograph estimations and to direct anatomic work- are converted to logarithmic values, and one is subtract-
ing length measurements. The Endex was slightly more ed from the other. The result drives the meter. The
reliable than the radiographic technique: 81% of the rationale of the JUSTWO resembles that of the Root
Endex determinations were 0.5 to 0.0 mm from the ZX.422 The analog meter and audio indicator display the
apical constriction in the study.399 position of the instrument tip inside the canal. The unit
Two in vivo studies compared the Endex determina- determines working length in the presence of elec-
tions to radiographic working length estimations. One trolytes. Although no calibration is required, a calibra-
study reported that 63% of the determinations were tion check is recommended.
1.0 to 0.0 mm from the radiographic apex,409 where- Two in vitro studies have been reported on this
as the other study reported an accuracy of 89.6% ( 0.5 device. In one, in which electronic measurements were
mm from the apical constriction) in moist canals.415 compared to radiographic working length, the mean
One in vivo study reported that the Endex could be distance from the radiographic apex was 0.98 0.44
used to determine working length under various con- mm. In the other study, the device showed an average
ditions, such as bleeding, exudate, and hypochlorite in deviation of 0.04 0.05 mm from the direct anatomic
the canals.420 Four studies reported on the comparison working length measurement.423
of Endex determinations and direct anatomic measure- The APEX FINDER A.F.A. (All Fluids Allowed
ments. Two of the studies reported an accuracy of 72% Model 7005, Sybron Endo/Analytic; Orange, Calif.)
and 93%, respectively ( 0.5 mm from the apical fora- uses multiple frequencies and comparative impedance
men).364,418 A third study reported that about 66% of principles in its electronic circuitry (Figure 10-64). It is
the determinations were 0.75 to 0.0 mm from the api- reported to be accurate regardless of irrigants or fluids
cal constriction and the determinations were unaffect- in the canals being measured. It has a liquid crystal dis-
ed by pulp status.417 The fourth study reported that the play (LCD) panel that indicates the distance of the
determinations were coincident with the minor fora- instrument tip from the apical foramen in 0.1 mm
men in 37% of the canals and short in 47%.397 increments. It also has an audio chime indicator. The
The Neosono Ultima Ez Apex Locator (Satelec Inc; display has a bar graph canal condition indicator that
Mount Laurel, N.J.) is a third-generation device that reflects canal wetness/dryness and allows the user to
supersedes the second-generation Sono-Explorer line. To
circumvent the Japanese patents of two alternating cur-
rent frequencies, Amadent developed a device with mul-
tiple frequences and implanted a microchip that sorts out
two of the many frequencies to give an accurate reading
in either wet or dry canals. It works best in the presence
of sodium hypochlorite. The Ultima-Ez is mounted with
a root canal graphic showing file position as well as an
audible signal. The ability to set the digital readout at
0.5 or 1.0 mm allows measurements of wide open canals
as well. The Ultima-Ez also comes with an attached pulp
tester, called the Co-Pilot (Amadent; Cherry Hill, N.J.).
To date, the Dental Advisor (Ogden, Utah) has had five
consultants who used the device 26 times and reported its
reliability to be better in wet canals than in dry. They also
stated that it was Quick and easy to use.
The Mark V Plus (Moyco/Union Broach, Miller
Dental, Bethpage, N.Y.) is identical in circuitry and
performance to the Neosono Ultima Ez. To date, no
evaluations of the device have been published.
The JUSTWO or JUSTY II (Toesco Toei Engineering
Figure 10-64 The Apex Finder A.F.A. (All Fluids Allowed) third-
Co./Medidenta, Woodside, N.Y. and Japan) is another generation apex locator. It functions best with an electrolyte present
third-generation apex locator. The device uses frequen- and displays, on an LCD panel, the distance of the file tip from the
cies of 500 and 2,000 Hz in a relative value method.421 apex in 0.1 mm increments. (Courtesy of Sybron Endo/Analytic.)
improve canal conditions for electronic working length cal constriction, but, according to the manufacturer,
determination.424 The Endo Analyzer 8005 combines the 0.5-increment mark is an average of 0.2 to 0.3 mm
electronic apex location and pulp testing in one unit. beyond the apical constriction.428 The operating
McDonald et al. reported an in vitro study of the instructions for the Root ZX state, The working length
Apex Finder A.F.A.425 The device was able to locate the of the canal used to calculate the length of the filling
cementodentinal junction or a point 0.5 mm coronal material is actually somewhat shorter. Find the length
to it with 95% accuracy. of the apical seat (i.e., the end point of the filling mate-
The ROOT ZX (J. Morita Mfg. Co.; Irvine, Calif. and rial) by subtracting 0.5-1.0 mm from the working
Japan), a third-generation apex locator that uses dual- length indicated by the 0.5 reading on the meter.428
frequency and comparative impedance principles, was They suggested that the Root ZX should be used with
described by Kobayashi (Figure 10-65)387,388 The elec- the 0.0 or APEX increment mark as the most accurate
tronic method employed was the ratio method or apical reference point. The clinician should then adjust
division method. The Root ZX simultaneously meas- the working length on the endodontic instrument for
ures the two impedances at two frequencies (8 and 0.4 the margin of safety that is desired (ie, 1 mm short).
kHz) inside the canal. A microprocessor in the device A number of in vitro and in vivo studies on the accu-
calculates the ratio of the two impedances. The quo- racy and reliability of the Root ZX have been report-
tient of the impedances is displayed on an LCD meter ed.397,401,433438 Electronic working length determina-
panel and represents the position of the instrument tip tions made with the Root ZX were compared with
inside the canal. The quotient was hardly influenced direct anatomic working length measurements after
by the electrical conditions of the canal but changed extraction of the teeth in the study. Four studies indi-
considerably near the apical foramen.388 cated an accuracy for the Root ZX in the range of 82 to
The Root ZX is mainly based on detecting the change 100% ( 0.5 mm from the apical foramen).433438 One
in electrical capacitance that occurs near the apical con- study reported an accuracy of 82% ( 0.5 mm from the
striction.388 Some of the advantages of the Root ZX are apical constriction).401 McDonald et al. reported that
that it requires no adjustment or calibration and can be the Root ZX demonstrated 95% accuracy in their study
used when the canal is filled with strong electrolyte or when the parameters were 0.5 to 0.0 mm from the
when the canal is empty and moist. The meter is an cementodentinal junction.425
easy-to-read LCD. The position of the instrument tip Combination Apex Locator and Endodontic
inside the canal is indicated on the LCD meter and by the Handpiece. The Tri Auto ZX (J. Morita Mfg. Corp.
monitors audible signals. The Root ZX, as well as sever- USA; Irvine, Calif.) is a cordless electric endodontic
al other apex locators, allows shaping and cleaning of the handpiece with a built-in Root ZX apex locator
root canal with simultaneous, continuous monitoring of (Figure 10-66).439 The handpiece uses nickel-titanium
the working length.371,387,388,419,426429 rotary instruments that rotate at 280 50 rpm.440 The
Several studies have reported on the accuracy and position of the tip of the rotary instrument is continu-
reliability of the Root ZX.392,403,412,430432 In these ously monitored on the LED control panel of the hand-
studies, electronic working length determinations piece during the shaping and cleaning of the canal.
made by the Root ZX were compared with direct The Tri Auto ZX has three automatic safety mech-
anatomic working length mesurements. Three studies anisms. The handpiece automatically starts rotation
reported an accuracy for the device that ranged from when the instrument enters the canal and stops when
84 to 100% ( 0.5 mm from the apical fora- the instrument is removed (auto-start-stop mecha-
men).392,412,430 Murphy et al. used the apical constric- nism). The handpiece also automatically stops and
tion as the ideal apical reference point in the canal and reverses the rotation of the instrument when the
reported an accuracy of 44% in the narrow tolerance torque threshold (30 grams/centimeter) is exceeded
range of 0.0 to + 0.5 mm from the apical constric- (auto-torque-reverse mechanism), a mechanism
tion.402 One study reported that the Root ZX showed developed to prevent instrument breakage. In addi-
less average deviation than a second-generation device tion, the handpiece automatically stops and reverses
(Sono-Explorer Mark III) tested.432 rotation when the instrument tip reaches a distance
Studies on the Root ZX display increment marks from the apical constriction that has been preset by
reiterate that the Root ZX display is a relative scale and the clinician (auto-apical-reverse mechanism), a
does not indicate absolute intracanal distances from mechanism controlled by the built-in Root ZX apex
the apical constriction. In clinical practice, the 0.5- locator and developed to prevent instrumentation
increment mark is often taken to correspond to the api- beyond the apical constriction.
The Tri Auto ZX has four modes. In the Electronic auto-start-stop and the auto-torque-reverse mecha-
Measurement of Root (EMR) mode, a lip clip, hand file, nisms do not function. The auto-apical-reverse mecha-
and file holder are used with the apex locator in the nism does function. MANUAL mode is generally used
handpiece to determine working length. The handpiece with large instruments for coronal flaring.
motor does not operate in this mode. In LOW mode, the Kobayashi et al. suggested that to get the best
torque threshold is lower than in the HIGH mode. The results, it may be necessary to use some hand instru-
LOW mode is used with small to mid-sized instruments mentation in combination with the Tri Auto ZX,
for shaping and cleaning the apical and mid-third sec- depending on the difficulty and morphology of the
tions of the root canal. All three automatic safety mech- root canal being treated.439
anisms are functional in this mode. In HIGH mode, the In vitro, the accuracy of the EMR mode of the Tri
torque threshold is higher than the LOW mode but Auto ZX to determine working length to the apical
lower than the MANUAL mode. The HIGH mode is constriction has been reported at 0.02 0.06 mm.441
used with mid-size to large instruments for shaping and Another in vitro study reported that about half of the
cleaning in the mid-third and coronal-third sections of canals studied were short (0.48 0.10 mm) and half
the root canal. All three automatic safety mechanisms were long (+ 0.56 0.05).431 A second study conclud-
are functional in this mode. MANUAL mode offers the ed that shaping and cleaning with the Tri Auto ZX
highest threshold of torque. In MANUAL mode, the (AAR mechanism set at 1.0) consistently approximated
the apical constriction.442 The accuracy was reported to incomplete root formation requiring apexification.452
have 95% acceptable measurements ( 0.5 mm) in a They reported that in all cases, the EAL was 2 to 3 mm
study that compared the direct anatomic working short of the radiographic apex at the beginning of
length with the electronic working length.443 apexification therapy. When the apical closure was
The accuracy of the level of instrumentation with the complete, the apex locator was then 100% accurate. In
Tri Auto ZX (J. Morita Mfg. Corp. USA; Irvine, Calif.) was cases of immature teeth with open apices, a study
reported in an in vivo study.444 The canals were shaped reported that apex locators were inaccurate.453 In con-
and cleaned with the Tri Auto ZX (low mode) with the trast, an in vivo study using absorbent paper points for
auto-apical-reverse mechanism set at 1.0. In all cases, radi- estimating the working lengths of immature teeth has
ographs showed that the preinstrumentation working been described.454 They reported that in 95% of the
length was within 0.5 mm of the final instrument working cases for which the working length was estimated by
length and without overextension of gutta-percha, instru- paper points, they were within 1 mm of the working
ment breakage, or canal transportation. length estimated by radiographs.
Other Apex-Locating Handpieces. Kobayashi et al. An in vitro study evaluated the accuracy of the Root
reported the development of a new ultrasonic root ZX in determining working length in primary teeth.455
canal system called the SOFY ZX (J. Morita Mfg. Corp.; Electronic determinations were compared with direct
Irvine, Calif.), which uses the Root ZX to electronically anatomic and radiographic working lengths. They
monitor the location of the file tip during all instru- reported that the electronic determinations were simi-
mentation procedures.445,446 The device minimizes the lar to the direct anatomic measurements (0.5 mm).
danger of overinstrumentation. Radiographic measurements were longer (0.4 to 0.7
The Endy 7000 (Ionyx SA, Blanquefort Cedex, mm) than electronic determinations.
France) is available in Europe. It is an endodontic hand- Apex locators can be very useful in management of
piece connected to an Endy apex locator that reverses the inpatients and outpatients. For example, they can be an
rotation of the endodontic instrument when it reaches a important tool in endodontic treatment in the operat-
point in the apical region preset by the clinician. ing room. They also reduce the number of radi-
Other Uses of Apex Locators. Sunada suggested ographs, which may be important for those who are
the possibility of using apex locators to detect root per- very concerned about radiation hygiene. In some
forations.376 It was later reported that Electronic Apex patients, such concern is so strong that dental radi-
Locators (EALs) could accurately determine the loca- ographs are refused. An apex locator can be of enor-
tion of root or pulpal floor perforations.447,448 The mous value in such situations.
method also aided in the diagnosis of external resorp- Contraindications. The use of apex locators, and
tion that had invaded the dental pulp space or internal other electrical devices such as pulp testers, electrosur-
resorption that had perforated to the external root sur- gical instruments, and desensitizing equipment, is con-
face.367 A method for conservative treatment of root traindicated for patients who have cardiac pacemak-
perforations using an apex locator and thermal com- ers. Electrical stimulation to the pacemaker patient can
paction has been reported.449 interfere with pacemaker function. The severity of the
An in vitro study to test the accuracy of the Root ZX interference depends on the specific type of pacemaker
to detect root perforations compared with other types and the patients dependence on it.456 In special cases,
of apex locators reported that all of the apex locators an apex locator may be used on a patient with a pace-
tested were acceptable for detection of root perfora- maker when it is done in close consultation with the
tions.450 No statistical significance was found between patients cardiologist.457
large perforations and small perforations. Prepared pin The Future. The future of apex locators is very
holes can be checked by apex locators to detect perfo- bright. Significant improvement in the reliability and
ration into the pulp or into the periodontal liga- accuracy of apex locators took place with the develop-
ment.451 Horizontal or vertical root fractures could ment of third-generation models. It is probable that
also be detected as well as post perforations. more dentists will now use apex locators in the man-
In this latter case, the EAL file holder is connected to agement of endodontic cases. At this time, however, the
a large file, and the file then contacts the top of the post. conclusions of studies have not demonstrated that
The Root ZX will sound a single sustained beep, and apex locators are clearly superior to radiographic tech-
the word APEX will begin flashing. niques, nor can they routinely replace radiographs in
An in vivo study has evaluated the usefulness of an working length determination. It has been demonstrat-
apex locator in endodontic treatment of teeth with ed that they are at least equally accurate.399
Studies have concluded that when apex locators are back up (or down) the canal with progressively larger
used in conjunction with radiographs, there is a reduc- instrumentsthe step-back or serial techniqueor
tion in the number of radiographs required365,408,458 and the opposite, starting at the cervical orifice with larger
that some of the problems associated with radiographic instruments and gradually progressing toward the apex
working length estimation can be eliminated.459 with smaller and smaller instrumentsthe step-down
An understanding of the morphology in the apical technique, also called crown-down filing.
one-third of the canal is essential.299308,311,312 Hybrid approaches have also developed out of the
Consideration should be given to adopting the parame- two methods. Starting coronally with larger instru-
ter of 0.5 to 0.0 mm (from the apical constriction) as the ments, often power driven, one works down the straight
most ideal apical reference point in the canal. Electronic coronal portion of the canal with progressively smaller
working length determinations should be accomplished instrumentsthe step-down approach. Then, at this
with multiple measurements and should be done in con- point, the procedure is reversed, starting at the apex
junction with the shaping and cleaning procedure. with small instruments and gradually increasing in size
Consideration should be given to the evaluation of the as one works back up the canalthe step-back
accuracy of obturation as an indicator of the accuracy of approach. This hybrid approach could be called, quite
the working length determination. Future apex locators clumsily, the step-down-step-back technique or modi-
should be able to determine working length in all electric fied double-flared technique. 463
conditions of the root canal without calibration. The Any one of these methods of preparing the root canal
meter display on future apex locators should accurately will ensure staying within the confines of the canal and
indicate how many millimeters the endodontic instru- delivering a continuously tapered preparation and, as
ment tip is from the apical constriction.371 Buchanan noted, eliminate blocking, apical ledging,
transportation, ripping, zipping and perforation.464
TECHNIQUES OF RADICULAR CAVITY Step-Back Preparation. Weine, Martin, Walton,
PREPARATION and Mullaney were early advocates of step-back, also
Over the years, there has been a gradual change in the called telescopic or serial root canal preparation.465468
ideal configuration of a prepared root canal. At one Designed to overcome instrument transportation in
time, the suggested shape was round and tapered, the apical-third canal, as described earlier (Figure 10-
almost parallel, resembling in silhouette an obelisk like 67), it has proved quite successful. When Weine coined
the Washington Monument, ending in a pyramid the term zip to describe this error of commission, it
matching the 75-degree point of the preparatory became a buzz word, directing attention to apical
instruments. After Schilders classic description of aberrant preparations, principally in curved canals.
cleaning and shaping, the more accepted shape for Walton has depicted these variations, ranging from
the finished canal has become a gradually increasing ledge to perforation to zip (Figure 10-68). The damage
taper, with the smallest diameter at the apical constric- not only destroys the apical constriction, so important
ture, terminating larger at the coronal orifice.460 to the compaction of the root canal filling, but also pro-
This gradually increasing taper is effective in final fill- duces an hourglass-shaped canal.469 In this, the nar-
ing for as Buchanan pointed out, the apical movement rowest width of the canal is transported far away from
of the cone into a tapered apical preparationonly the apex and prevents the proper cleansing and filling
tightens the apical seal.461 But, as Buchanan further of the apical region (see Figure 10-68). In the case of
noted, overzealous canal shaping to achieve this taper severely curved canals, perforation at the curves elbow
has been at the expense of tooth structure in the coronal leads to disastrous results (Figure 10-69).
two-thirds of the preparation leading to perforations Step-Back Preparation and Curved Canals. This
and, one might add, materially weakening the tooth.461 method of preparation has been well described by
Grossly tapered preparations may well go back to Berg, Mullaney.468 His approach has been modified, however,
an early Boston endodontist, who enlarged canals to to deliver a continuing tapered preparation.461
enormous size to accommodate large heated pluggers Mullaney divided the step-back preparation into two
used to condense warm sectional gutta-percha.462 phases. Phase I is the apical preparation starting at the
apical constriction. Phase II is the preparation of the
Step-Back or Step-Down? remainder of the canal, gradually stepping back while
As previously stated, two approaches to dbriding and increasing in size. The completion of the preparation is
shaping the canal have finally emerged: either starting at the Refining Phase IIA and IIB to produce the continu-
the apex with fine instruments and working ones way ing taper from apex to cervical (Figure 10-70).
A
Figure 10-69 Apical curve to the buccal of the palatal root went
undetected and was perforated by heavy instruments and then
overfilled. Right-angle radiographs failed to reveal buccal or lingual
curves. Step-back preparation could have prevented perforation.
(Courtesy of Dr. Richard E. Walton.)
A B C D
Figure 10-68 Hazards of overenlarging the apical curve. A, Small flexible instruments (No. 10 to No. 25) readily negotiate the curve. B,
Larger instruments (No. 30 and above) markedly increase in stiffness and cutting efficiency, causing ledge formation. C, Persistent enlarge-
ment with larger instruments results in perforation. D, A zip is formed when the working length is fully maintained and larger instruments
are used. (Courtesy of Dr. Richard E. Walton.)
Figure 10-70 Step-back preparation. A, Phase IApical preparation up to file No. 25 with recapitulation using prior size files. B, Phase II
Stepping-back procedure in 1 mm increments, Nos. 25 through 45. Recapitulation with a No. 25 file to full working length. C, Refining Phase
II-AGates-Glidden drills Nos. 2, 3, and 4 used to create coronal and midroot preparations. D, Refining Phase II-BNo. 25 file, circum-
ferential filing smooths step-back. E, Completed preparationa continuous flowing flared preparation from the cementodentinoenamel
junction to the crown. Adapted with permission from Mullaney TP.468
canal silhouette in the film.461,464 He made the point for they are directly in line with the x-ray beam. Their
that the bladed part of the file must be bent all the way, apical orifices appear on the film well short of the root
even up to the last half millimeter, remembering that apex. So, curving the file to match the canal is para-
canals curve most in the apical one-third470 (Figure mount to success in the step-back maneuver unless
10-72). One must also remember that the most difficult nickel-titanium files are used. Attempting to curve
curves to deal with are to the buccal and/or the lingual nickel-titanium files can introduce metal fatigue.
A B
Figure 10-72 A, Stainless steel file series appropriately bent for
continuously tapering preparation. Note that the instrument shaft
straightens more and more with size increase. B, The file on the left
is bent for straight or slightly curved canals. The file on the right is
bent to initially explore and negotiate abrupt apical canal curva-
tures. Reproduced with permission from Buchanan LS.464
restriction only to size 25. Hawrish pointed out the Figure 10-74 A stylized step-back (telescopic) preparation. A
apparent lack of interest in canal diameter versus the working length of 20 mm is used as an example. The apical 2 to 3
great interest in the proper canal length (personal com- mm are prepared to size 25. The next 5 mm are prepared with suc-
cessively larger instruments. Recapitulation with No. 25 to full
munication, 1999). Many, in fact most, canals should be
length between each step. The coronal part of the canal is enlarged
enlarged beyond size 25 at the apical constriction in order with circumferential filing or Gates-Glidden drills. Reproduced
to round out the preparation at this point and remove as with permission from Tidmarsh BG. Int Endod J 1982;15:53.
much of the extraneous tissue, debris, and lateral canals
as possible. A size 25 file is used here as an example and
as a danger point for beyond No. 25 lies danger! Thus, the preparation steps back up the canal 1 mm
As stainless steel instruments become larger, they and one larger instrument at a time. When that portion
become stiffer. Metal memory plus stress on the of the canal is reached, usually the straight midcanal,
instrument starts its straightening. It will no longer stay where the instruments no longer fit tightly, then
curved and starts to dig, to zip the outside (convex) wall perimeter filing may begin, along with plenty of irriga-
of the canal. tion (Figure 10-75).
It must be emphasized here that irrigation between It is at this point that Hedstroem files are most effec-
each instrument use is now in order, as well as recapit- tive. They are much more aggressive rasps than the K
ulation with the previous smaller instrument carried to files. The canal is shaped into the continuous taper so
full depth and watch wound. This breaks up the apical conducive to optimum obturation. Care must be taken
debris so that it may be washed away by the sodium to recapitulate between each instrument with the orig-
hypochlorite. All of these maneuvers (curved instru- inal No. 25 file along with ample irrigation.
ments, lubrication, cleaning debris from the used This midcanal area is the region where reshaping
instrument, copious irrigation, and recapitulation) will can also be done with power-driven instruments:
ensure patency of the canal to the apical constriction. Gates-Glidden drills, starting with the smaller drills
Phase II. In a fine canal (and in this example), the (Nos. 1 and 2) and gradually increasing in size to No. 4,
step-back process begins with a No. 30 K-style file. Its 5, or 6. Proper continuing taper is developed to finish
working length is set 1 mm short of the full working Phase IIA preparation. Gates-Glidden drills must be
length. It is precurved, lubricated, carried down the used with great care because they tend to screw them-
canal to the new shortened depth, watch wound, and selves into the canal, binding and then breaking. To
retracted. The same process is repeated until the No. 30 avoid this, it has been recommended that the larger
is loose at this adjusted length (Figure 10-74). sizes be run in reverse. But, unfortunately, they do not
Recapitulation to full length with a No. 25 file follows to cut as well when reversed. A better suggestion is to
ensure patency to the constriction. This is followed by lubricate the drill heavily with RC-Prep or Glyde,
copious irrigation before the next curved instrument is which will prevent binding and the rapid advance
introduced. In this case, it is a No. 35, again shortened problem. Lubrication also suspends the chips and
by 1.0 mm from the No. 30 (2.0 mm from the apical No. allows for a better feel of the cutting as well as the first
25). It is curved, lubricated, inserted, watch wound, and canal curvature. Used Gates-Glidden drills are also less
retracted followed by recapitulation and irrigation. aggressive than new ones.
A B
Figure 10-78 A, Ovoid canal shape in a young mandibular molar sectioned just below the floor of the pulp chamber. The distal canal
(top) and the mesiobuccal canal (lower left) both require perimeter filing to complete their preparation. Watch-winding or reaming action
alone would accurately shape mesiolingual canal (lower right) into a round tapered preparation. B, Dumbbell-shaped canal that could not
accurately be enlarged into a round tapered preparation. Perimeter filing action and multiple gutta-percha point filling would be required to
accurately shape and obturate this shape of a canal. Tactile sensation with a curved exploring instrument should inform the operator that he
is not dealing with a round tapered canal. (Note related abscess, upper left.)
Chelation and Enlargement. A number of canals, small constrictions in the coronal part of the canal. If
particularly fine curved canals, will appear to be almost working length is estimated to be 20 mm but the clini-
calcified or blocked by attached pulp stones. They may cian can negotiate only 10 mm of canal, increasing the
still be negotiated if the clinician uses a chelating agent taper of the canal to the 10 mm level often removes the
and the utmost patience. constrictions and allows a small file to negotiate farther
Ethylenediaminetetraacetic acid buffered to a pH of into the canal. This is one of the strengths of following
7.3 was long ago advocated by Nygaard-stby to dis- the step-down or crown-down technique.
solve a pathway for exploring instruments.275,479 When Fraser has shown that, contrary to popular belief,
the mineral salts have been removed from the obstruct- chelating agents do not soften dentin in the narrow parts
ing dentin by chelation, only the softened matrix of the canal, although softening can occur in the cervical
remains.480 This may be removed by careful watch-wind- and middle portions.481,482 Ethylenediaminetetraacetic
ing action to drill past the obstruction. This maneuver acid must be concentrated enough in an area to be
may be improved if the coronal portion of the canal is effective.
widened so that only the instrument tip is cutting. R C Prep, File-Eze, and Glyde, which contain EDTA,
Files with tapers greater than the traditional 0.02 act more as lubricating agents since the concentration
mm/mm have made negotiating these calcified canals of EDTA contained therein is very modest. The Canal
more predictable. Calcification occurs nearest the irri- Finder System, using No. 08 files, has been very effec-
tant to which the pulp is reacting. Since most irritants tive in opening curved calcified canals in the presence
are in the coronal region of the pulp, the farther apical of an EDTA lubricant.
one goes into the canal, the more unlikely it is to be cal- Selden and McSpadden have recommended the use
cified. When files bind in these canals, it may be from of a dental operating microscope for peering down
calcified canals.483,484 More recently, the fiber-optic the file is binding at the apex. But, more often than
endoscope, such as used in abdominal and brain sur- not, the file is binding in the coronal canal. In this
gery, has given dentists a whole new look at the pulpal case, one should start with a wider (0.04 or 0.06 taper)
floor and the root canal. The OraScope (Spectrum instrument or a Gates-Glidden drill to free up the
Dental Inc; North Attlebora, Mass.), for example, has a canal so that a fine instrument may reach the mid- and
0.9 mm fiber-optic probe that will penetrate down the apical canal. This would be the beginning of step-
root canal, displaying its view, enormously magnified, down preparation. Buchanan has also emphasized the
on a computer screen. Incidentally, there is recent evi- importance of removing all pulp remnants before
dence that root canal calcification may be associated shaping begins to ensure that this tissue does not pile
with long-term prednisone therapy (60 mg per day up at the constriction and impede full cleaning and
over 8 years to treat lupus erythematosus).485 shaping to that point.461
K-File Series Step-Down Technique. As stated
Step-Down TechniqueHand Instrumentation above, the initial penetrating instrument is a small,
Initially, Marshall and Pappin advocated a curved, stainless steel K file, exploring to the apical con-
Crown-Down Pressureless Preparation in which striction and establishing working length. To ensure
Gates-Glidden drills and larger files are first used in this penetration, one may have to enlarge the coronal
the coronal two-thirds of the canals and then progres- third of the canal with progressively smaller Gates-
sively smaller files are used from the crown down Glidden drills or with instruments of larger taper such
until the desired length is reached486 This has become as the .04 or the .06 instruments. At this point, and in
known as the step-down or crown-down technique of the presence of sodium hypochlorite and/or a lubricant
cleaning and shaping. It has risen in popularity, espe- such as Glyde, step-down cleaning and shaping begins
cially among those using nickel-titanium instruments with K-Flex, Triple-Flex, or Safety Hedstrom (Sybron
with varying tapers. Endo/Kerr; Orange, Calif.) instruments in either the
A primary purpose of this technique is to minimize 0.02, 0.04, or 0.06 taper configuration depending on
or eliminate the amount of necrotic debris that could be the canal size to begin with. Starting with a No. 50
extruded through the apical foramen during instru- instrument (for example) and working down the canal
mentation. This would help prevent post-treatment dis- to, say, a size No. 15, the instruments are used in a
comfort, incomplete cleansing, and difficulty in achiev- watch-winding motion until the apical constriction (or
ing a biocompatible seal at the apical constriction.486 working length) is reached. When resistance is met to
One of the major advantages of step-down prepara- further penetration, the next smallest size is used.
tion is the freedom from constraint of the apical Irrigation should follow the use of each instrument and
enlarging instruments. By first flaring the coronal two- recapitulation after every other instrument. To proper-
thirds of the canal, the final apical instruments are ly enlarge the apical third, and to round out ovoid
unencumbered through most of their length. This shape and lateral canal orifices, a reverse order of
increased access allows greater control and less chance instruments may be used starting with a No. 20 (for
of zipping near the apical constriction.487 In addition, example) and enlarging this region to a No. 40 or 50
it provides a coronal escapeway that reduces the pis- (for example). The tapered shape can be improved by
ton in a cylinder effect responsible for debris extrusion stepping back up the canal with ever larger instru-
from the apex.488 ments, bearing in mind all the time the importance of
Step-Down, Step-by-Step. In this method, the lubrication, irrigation, and recapitulation. At this
access cavity is filled with sodium hypochlorite, and point, the canal should be ready for smear layer
the first instrument is introduced into the canal. At removal, drying, and either medication or obturation.
this point, there is a divergence in technique dictated Modified Technique. There have been a number of
by the instrument design and the protocol for pro- modifications of the step-down technique since it was first
ceeding recommended by each instrument manufac- promulgated. One of the most recent was by Ruddle (per-
turer. All of the directions, however, start with explo- sonal communication, 2001). Following complete access,
ration of the canal with a fine, stainless steel, .02 taper he suggested that clinicians face-off the orifices with an
(No. 8, 10, 15, or 20 file, determined by the canal appropriately sized Gates-Glidden drill. This creates a
width), curved instrument. It is important that the smooth guide path to facilitate the placement of subse-
canal be patent to the apical constriction before clean- quent instruments. Certain canal systems contain deep
ing and shaping begin. Sometimes the chosen file will divisions and may be initially opened at their coronal ends
not reach the apical constriction, and one assumes that with Micro Openers (Dentsply Maillefer; Tulsa, Okla.).
If the pulp is vital, a broach may be selected to sure, before retraction. The instrument is cleaned and
quickly extirpate it if space permits. At this stage of the operation repeated until the instrument is loose. A
treatment, the coronal two-thirds of any canal should lubricant such as RC PREP or GLYDE should be used.
be scouted with a No. 10 or 15 curved, stainless steel At this point, the canal should be flooded with EDTA
K file in the presence of a lubricant and/or sodium and the next smaller-size GT file is used, number 0.08,
hypochlorite. Exploration of this portion of the canal in the same mannercounterclockwise, engage, twist
will confirm straight-line access, cross-sectional diam- clockwise, and retract. One continues down the canal
eter, and root canal system anatomy. Files are used seri- using the 0.08, and 0.06 taper instruments until the api-
ally to flare the canal until sufficient space is generated cal restriction is reached. Constant irrigation with sodi-
to safely introduce either Gates-Gliddens or nickel-tita- um hypochlorite is most important! This constitutes
nium rotary shaping files. Frequent irrigation with what Buchanan terms the Second Shaping Wave, and
sodium hypochlorite and recapitulation with a No. 10 it should be completed in a matter of minutes.
file will discourage canal blockage and move debris The second wave is followed by the Third Shaping
into solution, where it can be liberated from the root Wave, in which regular ISO instruments are used to
canal system. One way to accomplish pre-enlargement the constriction to enlarge the apical canal diameter
of the canal is with Gates-Glidden drills that are used at beyond size 20, the tip diameter of the GT files.
approximately 800 rpm, serially, passively, and like a Beginning with fine instruments, and then stepping
brush to remove restrictive dentin. Initially, one should back 1 or 2 mm with instruments, up to size 35 or 40,
start with a Gates-Glidden drill No. 1 and carry each the apical region is rounded out. The final shaping is
larger instrument short of the previous instrument to a return of the last GT file used in the canal.
promote a smooth, flowing, tapered preparation. Buchanan pointed out that the GT instruments are
Frequent irrigation with sodium hypochlorite and sized to fit certain size canals. The 0.06 file, for instance,
recapitulation with a small clearing file to prevent is recommended for extremely thin or curved roots.
blockage are in order. The 0.08 file is best for lower anterior teeth, multirooted
Following pre-enlargement, Ruddle believes in nego- premolars, and the buccal roots of maxillary molars. The
tiating the apical one-third last, establishing patency, 0.10 file better matches the distal canal of mandibular
and confirming working length. He then recommends molars, the palatal roots of maxillary molars, single-
finishing the apical zone so that there is a smooth uni- canal premolars, mandibular canines, and maxillary
form taper from the orifice level to the radiographic ter- anterior teeth. The 0.12 instrument is for larger canals.
minus. He emphasized that a variety of instruments Buchanan is a great believer in the necessity of clean-
may be used to create the deep shape. If the clinician ing what he terms the patency zone, that tiny space
chooses 0.02 tapered files to finish the apical one- between the apical constriction and the apical terminus.
third, Ruddle uses a concept he calls Gauging and For this, in the presence of sodium hypochlorite, he
Tuning. Gauging is knowing the cross-sectional carefully instruments this space with a regular No. 10
diameter of the foramen that is confirmed by the size of file. He also believes that sodium hypochlorite should
instrument that snugs in at working length. Tuning be present in this region for a total of 30 minutes. If
is ensuring that each sequentially larger instrument uni- preparation time has been less than 30 minutes, he rec-
formly backs out of the canal 12 mm. ommends that a final lavage should remain in the canal
After removing the sodium hypochlorite, the canal is until 30 minutes have passed. This, in his view, dissolves
rinsed with 17% aqueous EDTA to remove the smear the final debris and tissue packed there, even in the
layer in preparation for obturation. Dentsply Maillefer accessory canals (personal communication, 2001).
has developed a Clean & Shape Kit that contains all of Quantec Instrument Technique. Using Quantec
the instruments necessary for this technique. instruments (Sybron Endo/Analytic; Orange, Calif.),
PROFILE GT (Greater Taper) Technique. If these which are more reamer like than files, the recommended
instruments (Dentsply/Tulsa Dental; Tulsa, Okla.) are technique for hand instrumentation is divided into three
used, Buchanan, the developer, recommends that one phases: negotiation, shaping, and apical preparation.
start with a 0.10 GT instrument to flare out the coronal NEGOTIATION: As is standard with virtually all
third of the canal. This means that this instrument is an cleaning and shaping techniques, the canal, in the pres-
ISO size 20 at the tip, but the taper is 0.10 mm/mm, that ence of sodium hypochlorite, is first explored with a
establishes a wider freedom for those instruments to standard No. 10 or 15 0.02 taper, curved, stainless steel
follow. The instrument is used in a twisting motion, first K file and working length is established (Figure 10-79,
counterclockwise and then clockwise with apical pres- A). Exploration is followed by a Quantec No. 25, 0.06
taper, nickel-titanium instrument, advanced in a ream- with the development and introduction of a new K-
ing action, from the canal orifice to just short of the type file design, the Flex-R File100,101 (Moyco Union
apical third, and followed by irrigation with sodium Broach). The technique can be described as position-
hypochlorite (Figure 10-79, B and C). ing and pre-loading an instrument through a clockwise
With a standard ISO 0.02, stainless steel, No. 10 or rotation and then shaping the canal with a counter-
15 file, a Glide Path for the instruments to follow is clockwise rotation.100 The authors evaluated damaged
developed to working length (Figure 10-79, D). The instruments produced by the use of this technique.
canal is then irrigated with EDTA (Figure 10-79, E), They discovered that a greater risk of instrument dam-
and the No. 20 and 25 stainless steel, 0.02 instruments age was associated with clockwise movement.85
are used to clean and shape the apical third to the api- For the best results, preparation is completed in a
cal constriction. This is followed again by copious irri- step-down approach. The coronal and mid-thirds of a
gation (Figure 10-79, F). canal are flared with Gates-Glidden drills, sizes 2
SHAPING: Using lubricants and sodium hypochlo- through 6, and then instrument shaping is carried into
rite, one returns to the Quantec instruments, all with the apical areas. This approach is less difficult than the
an ISO size No. 25 tip. Returning to the No. 25, 0.06 conventional step-back technique. Increasing the
taper instrument, it is used in a reaming action, as far diameter of the coronal and mid-thirds of a canal
down the canal as it will comfortably go (Figure 10-79, removes most of the contamination and provides
G). It is followed in succession by the No. 0.05 taper access for a more passive movement of hand instru-
Quantec and then the 0.04 and 0.03 tapers until the ments into the apical third. Shaping becomes less diffi-
apical stop is reached (Figure 10-79, H to J). Copious cult: the radius of curvature is increased as the arc is
irrigation follows the use of each instrument. decreased. In other words, the canal becomes straighter
QUANTEC APICAL PREPARATION: To ensure accuracy, and the apex accessible with less flexing of the shaping
the working length should be rechecked. If an apical instruments (Figure 10-80).
preparation larger in diameter than a No. 25 is desired, After mechanical shaping with Gates-Glidden drills,
one may return to the 0.02 taper Quantec instruments balanced force hand instrumentation begins: placing,
(which will now be quite loose in the midcanal), and cutting, and removing instruments using only rotary
the diameter of the apical third can then be enlarged up motions (Figure 10-80, C). Insertion is done with a
to a size No. 40, 45, or 50, depending on the original quarter-turn clockwise rotation while slight apical
size of the canal (Figure 10-79, K). Final irrigation to pressure is applied (Figure 10-81, 1). Cutting is accom-
remove the smear layer with EDTA and sodium plished by making a counterclockwise rotation, again
hypochlorite prepares the tapered canal for medication while applying a light apical pressure (Figure 10-81, 2).
or filling (Figure 10-79, L). The amount of apical pressure must be adjusted to
Efficacy of the Step-Down Technique. Compared match the file size (ie, very light for fine instruments to
to the step-back circumferential filing technique with fairly heavy for large instruments).100 Pressure should
precurved files as described by Weine,488 Morgan and maintain the instrument at or near its clockwise inser-
Montgomery found the step-down technique signifi- tion depth. Then counterclockwise rotation and apical
cantly better in shape and terminus.489 pressure act together to enlarge and shape the canal to
Another in vitro study found significantly less debris the diameter of the instrument. Counterclockwise
extruded from the apical orifice when step-down pro- motion must be 120 degrees or greater. It must rotate
cedures were used compared to step-back procedures. the instrument sufficiently to move the next larger cut-
Neither technique was totally effective, however, in pre- ting edge into the location of the blade that preceded it,
venting total debris extrusion.490 in order to shape the full circumference of a canal. A
greater degree of rotation is preferred and will more
Variation of the Three Basic Preparations completely shape the canal to provide a diameter equal
A variety of techniques have been developed, all based to or greater than that established by the counterclock-
on the step-down, step-back, or hybrid approach to wise instrument twisting during manufacture.
preparation. Most are inspired by new canal instru- It is important to understand that clockwise rotation
ments and/or vibratory devices. sets the instrument, and this motion should not
Balanced Force Concept Using Flex-R Files. After exceed 90 degrees. If excess clockwise rotation is used,
many years of experimentation, Roane et al. introduced the instrument tip can become locked into place and
their Balanced Force concept of canal preparaton in the file may unwind. If continued, when twisted coun-
1985.100 The concept came to fruition, they claimed, terclockwise, the file may fail unexpectedly. The process
Figure 10-79 Step-down technique, with Quantec hand instruments, cleaning and shaping. A, Explore to the apex and establish working
length (WL) with a stainless steel (SS) No. 10 or 15 0.02 taper file. B, Enlarge the orifices and two-thirds of the way down the canal with a nick-
el-titanium (NiTi) No. 25 0.06 taper file. C, Irrigate all of the canals with sodium hypochlorite (NaOCl). D, Establish a glide path to WL with
SS No. 15, 0.02 taper file. E, Irrigate with ethylenediaminetetraacetic acid (EDTA). F, Enlarge to WL with SS No. 20 and 25 0.02 files. Irrigate
with NaOCl. G, With Glyde and NaOCl, enlarge down the canal as far as possible with NiTi No. 25 0.06 file. Irrigate. H, Continue further down
the canal with a NiTi No. 25 0.05 file. I, Continue further with a No. 25 0.04 file. J, Continue to WL with a NiTi No. 25 0.03 file. K, Enlarge
apical one-third up to size Nos. 40, 45, or 50 with 0.02 taper files. L, Final irrigation with EDTA and NaOCl to remove smear layer. Dry.
Figure 10-80 a, File displays full curvature of the canal before radicular access is modified. b, Radicular access is completed with a descend-
ing series of Gates-Glidden drills progressing toward the apex in 2.0 mm or less increments. c, The dotted line indicates the original curva-
ture, whereas the file displays the affective curvature after radicular access is improved. This modification materially reduces the difficulty of
apical shaping. (Courtesy of Dr. James B. Roane.)
is repeated (clockwise insertion and counterclockwise flutes and elevates it away from the apical foramen.100
cutting), and the instrument is advanced toward the Generous irrigation follows each shaping instrument
apex in shallow steps. After the working depth is since residual debris will cause transportation of the
obtained, the instrument is freed by one or more coun- shape. Debris applies supplemental pressures against
terclockwise rotations made while the depth is held the next shaping instrument and tends to cause
constant. The file is then removed from the canal with straightening of the curvature.
a slow clockwise rotation that loads debris into the Repeating the previously described steps, the clini-
cian gradually enlarges the apical third of the canal by
advancing to larger and larger instruments. Working
depths are changed between instruments to produce
an apical taper. The working loads can and should be
kept very light by limiting the clockwise motion and
thereby reducing the amount of tooth structure
removed by each counterclockwise shaping move-
ment. This technique can and should be used with
minimal force.
The balanced force technique can be used with any K-
type file491; however, the shaping and transportation con-
Figure 10-81 1. For a balanced force motion, the file is pushed trol are maximum when a Flex-R file is used.492 The Flex-
inwardly and rotated one quarter-turn clockwise. 2. It is then rotat- R file design incorporates a guiding plane and removes
ed more than one half-turn counterclockwise. The inward pressure the transition angles inherent on the tip of standard K-
must be enough to cause the instrument to maintain depth and
strip away dentin as it rotates counterclockwise. These alternate
type files (see Figure 10-23). Those angles, if present,
motions are repeated until the file reaches working length. enable the tip to cut in an outward direction and give it
(Courtesy of Dr. James B. Roane.) the ability to cut a ledge into the canal wall. Lacking a
Figure 10-82 Details of the final balanced force step-back preparation in the apical control zone. Apical constriction is formed at a meas-
ured depth for small, medium, or large canals. Root length (RL) and millimeters of step-back are shown left. Instrument size is shown right.
(Courtesy of Dr. James B. Roane.)
sharp transition angle, Flex-R files follow the canal and This shaping provides a minimum diameter at a known
are prevented from gouging into the walls. The tip design depth within the canal. A size 45 control zone is shaped
causes a Flex-R file to hug the inside of a curve and pre- by first expending a size 15 and 20 file to the periodon-
vents tip transport into the external wall of that curve.493 tal ligament and then reducing the working depth by 0.5
Balanced force instrumentation was born out of mm for sizes 25, 30, and 35 and completing the apical
necessity because Roane firmly believes in enlarging the shape 1 mm short using sizes 40 and 45. It goes without
apical area to sizes larger than generally practiced. He saying that sodium hypochlorite irrigation is used.
expects a minimum enlargement of size 45, 1.5 mm Single-appointment preparation and obturation are de
short of the foramen in curved canals, and size 80 in rigeur and also play an important role in the formation
larger single-rooted teeth (Figure 10-82). These sizes, of of these shaping concepts.
course, depend on root bulk, fragility, and the extent of The success of this shaping technique and enlarging
curvature. Sabala and Roane also believe in carrying the scheme has been closely evaluated in both clinical prac-
preparation through to full length, the radiographic tice and student clinics. Clinical responsiveness is
apex of the root. They purposely shape the foraminal impressive, and the efficiency has been unmatched until
area, and yet patients rarely experience flareups.494 A rotary shaping (Figure 10-83).
step-back in 12-mm increments is used with at least two Efficacy of Balanced Force Preparation. Sabala and
groups of instruments to form an apical control zone. Roane reported that, using the balanced force concept,
A B
Figure 10-83 Impressive result of balanced force canal preparation and obturation. A, Instruments in place demonstrating canal curvature.
B, Final obturation to extended sizes is more assurance that the canals have been thoroughly dbrided. (Courtesy of Dr. James B. Roane.)
students at the University of Oklahoma could enlarge used primarily in final canal dbridement. For canal
canals (in a laboratory exercise) with no measurable api- cleanliness, ultrasonic activation with a No. 15 file for 3
cal transportation.494 Moreover, the modified-tip instru- full minutes in the presence of 5% sodium hypochlo-
ment (Flex-R file) developed a nontransported prepara- rite produced smooth, clean canals, free of the smear
tion more frequently and predictably. Procedural acci- layer and superficial debris along their entire
dents occurred in 16.7% of the samples.493 In a previous length.498 This is exactly the technique used by a num-
publication, the authors concluded that most instru- ber of dentists seeking the cleanest canals in spite of
ments damaged by students (91.5%) using balanced which clean and shape technique they might have used.
force technique were damaged by overzealous clockwise This should be done after the smear layer has been
rotation.85 removed to ensure that all of the detritus, including
A University of Washington balanced force study, bacteria, is all flushed out.
using standard K-type files, concluded that effective Concern over the possible harmful effects of sodium
instrumentation of curved root canals may be accom- hypochlorite spilling out of the apical foramen was dealt
plished with straight instruments of fairly large size with at the State University of Louisiana. Investigators
without significant deviation from the original canal intentionally overinstrumented past the apex in a mon-
position. The original canal position was maintained key study and then evaluated the tissue response when
80% of the time after shaping with a No. 40 file. sodium hypochlorite was used with conventional filing
Original position was maintained in only 40% when a versus ultrasonic filing/irrigation. They were pleased to
size 45 file was the final apical instrument.491 A second find no significant difference between the two methods
University of Washington study compared balanced and a low to moderate inflammatory response.499
force and step-back techniques. This study disclosed Sonic. Sonic canal preparation and dbridement
that Balanced Force using Flex-R prototype files pro- with the Micro Mega 1500 Sonic Air (Micro
duced significantly less deviation from the center of the Mega/MediDenta, France/USA) handpiece has been
original canal than did the step-back method using quite popular, particularly with the military. Camp has
conventional K-type and Hedstroem files.492 The considerable experience with the Sonic handpiece and
authors noted that no instrument separations were instruments and recommended that stainless steel
experienced in this study. hand files size 10 or 15 first be used to establish a path-
McKendry at the University of Iowa reported that way down the canals until resistance is met, usually
the Balanced Force technique dbrided the apical canal about two-thirds of the canal length. He then begins
at least as adequately as the step-back filing technique the step-down approach with the sonic instruments
and as well as the CaviEndo ultrasonic method. the No. 15 Shaper or Rispisonic file (see Figure 10-34),
Furthermore, significantly less debris was extruded their length set 2 mm shy of the length reached with the
apically using balanced force compared to sonic or previous instrument. About 30 seconds are spent in
step-back preparations.495,496 While testing the each canal using a quick up and down, 2 to 3 mm
Balanced Force method at Georgia, the investigators stroke and circumferentially filing under water irriga-
found that early radicular flaring (step-back) made tion supplied by the handpiece. This is the time to
instrumentation much easier but did not necessarily remove any isthmus or fins between canals. The use of
improve the quality of the apical shape.497 each instrument is followed by copious sodium
It has been well established that the Balanced Force hypochlorite irrigation. The water from the handpiece
technique using guiding-tip files is fast and efficient. is turned off and the irrigant is agitated in the canal
However, Balanced Force, like any new technique, with the fine Sonic file.
should be practiced before it is used clinically. If exces- At this point, working length is established by a radi-
sive pressure is used, instrument separation may result. ograph or an electric apex locator, and the extension to
The large radicular shaping provided by use of Gates- the apical constriction is carried out with stainless steel
Glidden drills, if improperly guided, might cause a hand files to full working lengthNos. 15, 20, 25, and
strip perforation into the furcation. Use in undergrad- 30. Following sodium hypochlorite irrigation, Camp
uate clinics has proven this technique reliable and safe returns to the Sonic No. 15 (or a 20 or 25 in larger
for routine use. Once mastered, Balanced Force tech- canals) Shaper or Rispisonic file for 30 seconds in each
nique expands the shaping possibilities and extends canal. After irrigation, No. 30, 35, and 40 hand files are
ones operative abilities. again used followed by a larger Sonic instrument, and
Ultrasonic and Sonic Preparations. Ultrasonic. then No. 50 to 60 hand files are used to step-back up the
As stated before, ultrasonic instrumentation today is canal to ensure a tapered preparation. Final use of the
Figure 10-85 ProFile instrument sequence showing Orifice shapers and 0.04 tapers. (Courtesy of Dentsply/Tulsa Dental.)
range is still from 275 to 325 rpm.516 As these more In contrast to Profile Tapers, however, the total
tapered instruments are rotated, they produce an accel- length of the Orifice Openers is 19 mm, with a cutting
erated step-down preparation, resulting in a funnel- length of approximately 9 mm. Besides reducing file
form taper from orifice to apex. As these reamers separation, this shorter length also makes them easier
rotate clockwise, pulp tissue and dentinal debris are to manipulate in difficult access areas. ISO tip sizes of
removed and travel counterclockwise back up the 30, 40, and 50 are built into these files with tapers of
shaft. As a result, these instruments require periodic 0.06 and 0.07. These instruments serve the same func-
removal of dentin mud that has filled the U portion tion as the Quantec Flares.
of the file. The ProFile Variable Taper has a 60-degree bullet-
The U-blade design, similar in cross-section to the nose tip that smoothly joins the flat radial lands.
LightSpeed, has flat outer edges that cut with a planing
action, allowing it to remain more centered in the canal
compared to conventional instruments (Figure 10-
86).504506,509,510,515 The ProFile tapers also have a
built-in safety feature, in which, by patented design,
they purportedly unwind and then wind up backward
prior to breaking. These Profile Variable Taper instru-
ments are manufactured in standard ISO sizing as well
as Series 29 standards (ie, every instrument increases
29% in diameter).
The Orifice Shapers, in 0.06 and 0.07 mm/mm tapers,
are designed to replace Gates-Glidden drills for shaping
the coronal portion of the canal. Because of their
tapered, radial-landed flutes and U-file design, these
instruments remain centered in the canal while creating
Figure 10-86 Comparative cross-sectional shapes between a U-
a tapering preparation. In turn, this preflaring allows for shaped Profile 0.04 taper with a 90-degree rake angle and the con-
more effective cleaning and shaping of the apical half of ventional triangular reamer with a 60-degree cutting angle.
the canal with the Profile Series 0.04 Tapers. (Courtesy of Dentsply/Tulsa Dental.)
Although these tapers have a 90-degree cutting angle Profile System near the end of the canal preparation to
(Figure 10-87), the nonaggressive radial landed flutes blend the apical preparation with coronal preflare.
gently plane the walls without gouging and self-thread-
ing; in addition, they are cut deeper to add flexibility Canal Preparation
and help create a parallel inner core of metal. Thus, A basic technique that primarily uses Orifice Shapers
when the Profile Taper is rotated, stresses become more and Profile tapers is as follows: Once access, canal
evenly distributed along the entire instrument in con- patency, and an estimated working length have been
trast to a nonparallel core or tapered shaft of a conven- determined, the No. 30 0.06 taper Orifice Shaper is
tional instrument in which stresses are more concen- taken several millimeters into the canal, thus creating
trated toward the tip of its narrow end. An investiga- a pathway for the next instruments. The No. 50 0.07
tion by Blum, Mactou et al., however, demonstrated Orifice Shaper is then used to create more coronal
that torque can still develop at the apical 3 mm of the flare followed by the No. 40 0.06 taper Orifice
ProFiles even when used in a step-down procedure.517 Shaper. This last instrument should be advanced
ProFile instruments are available in either 0.04 about halfway down the canal using minimal pres-
(double taper) or 0.06 (triple taper) over the ISO 0.02 sure. Constant irrigation and recapitulation must be
taper. Kavanaugh and Lumley found no significant dif- followed throughout the entire sequence.
ferences between the 0.04 and 0.06 tapers with respect A working length radiograph is then taken with a
to canal transportation. On the other hand, the use of stainless steel hand file to determine the precise length.
0.06 tapers improved canal shape.515 The 0.04 is more The tip of all subsequent tapers becomes a guide as the
suitable for small canals and apical regions of most instrument cuts higher up the shaft, mostly with the mid-
canals, including the mesial roots of mandibular dle blades. In all cases, a ProFile taper file should never be
molars and buccal roots of maxillary molars. The 0.06 used in the canal longer than 4 to 6 seconds. The clini-
is recommended for the midroot portions of most cian must now passively advance the 0.04 or 0.06 taper
canals, distal roots of mandibular molars, and palatal instruments, or combinations thereof, to or near the
roots of maxillary molars. Similar to the graduating working length. As the rotary reamers move closer to
taper technique of the Quantec Series, the clinician has length, a funnel shape is imparted to the canal walls. In
the option of using alternating tapers within a single most cases, a No. 30 or an equivalent 29 Series 0.04 taper
canal (ie, combinations of 0.04, 0.06, and 0.07 taper eventually reaches at or near the working length with
ProFile instruments). minimal resistance. In more constricted cases, however, a
Since the development of the ProFile tapers, a num- No. 25 or 20 0.04 taper may be the first to reach the work-
ber of methods for use have been espoused. As such, ing length. If the tapers are not taken to full working
there is currently no recommended stand-alone tech- length, hand files, either stainless steel or nickel-titanium,
nique. In fact, a number of clinicians incorporate the can be used to complete the apical 1 to 2 mm.
Figure 10-88 Profile GT Rotary sizes and tapers of the standard GT: 0.06, 0.08, 0.10, and 0.12 mm/mm tapers with a common ISO size 20
tip and the Accessory files with a common 0.12 mm/mm taper but variable tips of ISO sizes 35, 50, and 70. (Courtesy of Dentsply/Tulsa
Dental.)
mum flute diameter is also set at 1.0 mm, safely limit- three steps: step-down with ProFile GTs and then step
ing coronal enlargement. back with ProFile 0.04 taper files and a GT file to create
Because the GT files vary by taper but have the same final canal shape. As in all rotary techniques, a step-
tip diameters and maximum flute diameters, the flute down approach is used once initial negotiation is com-
lengths become shorter as the tapers increase. The 0.06 pleted with hand files and lubricant. Standard GT files
taper is designed for moderate to severely curved canals (0.12, 0.10, 0.08, and 0.06 tapers) are then used in a
in small roots, the 0.08 taper for straight to moderately step-down manner at 150 to 300 rpm, allowing each to
curved canals in small roots, and the 0.10 taper for cut to their passive lengths.
straight to moderately curved canals in large roots. A set Working length should be determined once the GT
of three accessory GT files (see Figure 10-88) is available file has reached two-thirds of the estimated length of
for unusually large root canals having apical diameters the canal. In some cases, the 0.06 taper will reach full
greater than 0.3 mm. These instruments have a taper of length. Since the standard GT files all have a 0.20 mm
0.12 mm per mm, a larger maximum flute diameter of tip diameter, the 0.08 and 0.10 taper files should easily
1.5 mm, and varying tip diameters of 0.35, 0.50, and go to length if a 0.08 or 0.10 taper is desired for that
0.70 mm. When used in canals with large apical diame- particular canal.
ters, they are typically able to complete the whole shape Rather than using the GT file to the apical terminus,
with one file. The ProFile GT files are thus designed so a variation of the technique involves the creation of an
that the final taper of the preparation is essentially apical taper. ProFile 0.04 taper instruments, usually
equivalent to the respective GT file used. sizes 25 to 35, can be used in a step-back fashion, start-
A recent study (unpublished, 2000) conducted at the ing about 2 mm short of working length. The standard
University of Pacific found that undergraduate dental GT files can then be used in a step-down fashion again
students, who were trained in the GT rotary technique, to create the final canal shape right to working length,
completed shapes in 75% less time than with standard or, if preferred, hand instruments may be used to shape
K files and Gates-Glidden drills. Shapes were also the apical 2 mm of the canal. If additional coronal flare
rounder throughout their lengths, and coronal canal is needed, an appropriate GT accessory file can be used.
shaping was more conservative. With the ProFile GT rotary instrumentation tech-
Canal Preparation. According to the manufactur- nique, as with most other nickel-titanium rotary tech-
er, the ProFile GT technique can be broken down into niques, basic rules need to be adhered to. Speeds must
be kept constant, a light touch must be used, the GT each millimeter over the 14 mm length of their cutting
files should not be used in a canal more than 4 to 6 sec- blades. This is what makes the instruments unique.
onds, and irrigation and lubrication must be continu- Shaping File S-1 is designed to prepare the coronal
ally used throughout the procedure. one-third of the canal, whereas Shaping File S-2
enlarges and prepares the middle third in addition to
ProTaper Rotary System the critical coronal region of the apical third.
According to the developers, ProTaper (Progressively Eventually, both size instruments may also help enlarge
Tapered), nickel-titanium rotary files substantially sim- the apical third of the canal as well.
plify root canal preparation, particularly in curved and Finishing Files. The three finishing files have been
restricted canals. The claim is made that they consis- designed to plane away the variations in canal diame-
tently produce proper canal shaping that enables pre- ter in the apical one-third. Finishing Files F-1, F-2,
dictable obturation by any vertical obturation method. and F-3 have tip diameters (D0) of ISO sizes 20, 25,
This new instrument system, consisting of three shap- and 30, respectively. Their tapers differ as well (Figure
ing and three finishing files, was co-developed by 10-89, C). Between D0 nd D3, they taper at rates of
Drs. Clifford Ruddle, John West, Pierre Mactou, and 0.07, 0.08, and 0.09 mm/mm, respectively. From D4 to
Ben Johnson and was designed by Franois Aeby and D14, each instrument shows a decreased taper that
Gilbert Rota of Dentsply/Maillefer in Switzerland. improves its flexibility.
The distinguishing feature of the ProTaper System Although primarily designed to finish the apical
(Dentsply/Tulsa Dental) is the progressively variable third of the canal, finishers do progressively expand the
tapers of each instrument that develop a progressive middle third as well. Generally, only one instrument is
preparation in both vertical and horizontal directions. needed to prepare the apical third to working length,
Under use, the file blades engage a smaller area of and tip sizes (0.20, 0.25, or 0.30) will be selected based
dentin, thus reducing torsional load that leads to on the canals curvature and cross-sectional diameter.
instrument fatigue and file separation. During rota- Finisher F-3 has been further engineered to increase its
tion, there is also an increased tactile sense when com- flexibility in spite of its size (Figure 10-89, D).
pared with traditionally shaped rotary instruments.
Taper lock is reportedly reduced, extending a newly ProTaper Benefits.
found freedom from concern about breakage. As with
1. The progressive (multiple) taper design improves
any new system, however, the ProTaper beginner is
flexibility and carving efficiency, an important
advised to first practice on extracted teeth with restrict-
asset in curved and restrictive canals (Figure 10-
ed curved canals.
89, E).
ProTaper Configurations. As previously stated,
2. The balanced pitch and helical angles of the instru-
the ProTaper System consists of only six instrument
ment optimize cutting action while effectively
sizes: three shaping files and three finishing files.
augering debris coronally, as well as preventing the
Shaping Files. The Shaping Files are labeled S-X, S-
instrument from screwing into the canal.
1, and S-2. The S-X Shaper (Figure 10-89, A) is an aux-
3. Both the shapers and the finishers remove the
iliary instrument used in canals of teeth with shorter
debris and soft tissue from the canal and finish the
roots or to extend and expand the coronal aspects of
preparation with a smooth continuous taper.
the preparation, similar to the use of Gates-Glidden
4. The triangular cross-section of the instruments
drills or orifice openers. The S-X has a much increased
increases safety, cutting action, and tactile sense
rate of taper from D0 (tip diameter) to D9 (9.0 mm
while reducing the lateral contact area between the
point on the blades) than do the other two shapers, S-
file and the dentin (Figure 10-89, F).
1 and S-2. At the tip (D0), the S-X shaper has an ISO
5. The modified guiding instrument tip can easily fol-
diameter of 0.19 mm. This rises to 1.1 mm at D9 (com-
low a prepared glide path without gouging side walls.
parable to the tip size of a size 110 ISO instrument).
After D9, the rate of taper drops off up to D14, which
Canal Preparation.
thins and increases the flexibility of the instrument.
ProTaper System: Guidelines for Use
The S-1 and S-2 files start at tip sizes of 0.17 mm and
0.20 mm, respectively, and each file gains in taper up to 1. Prepare a straight-line access cavity with no restric-
1.2 mm (Figure 10-89, B). But unlike the consistent tions in the entry path into the chamber.
increase of taper per millimeter in the ISO instruments, 2. Fill the access cavity brimful with sodium
the ProTaper Shapers have increasingly larger tapers hypochlorite and/or ProLube.
A B
C D
E F
Figure 10-89 The ProTaper File Rotary System. A, Shaping File X, an auxiliary instrument used primarily to extend canal orifices and
widen access as well as create coronal two-thirds shaping in short teeth. B, Shaping Files 1 and 2, used primarily to open and expand the
coronal and middle thirds of the canal. C, Finishing Files 1, 2, and 3, used to expand and finish the apical third of progressively larger canals.
D, Finishing File 3 is used to finish the apical third of larger canals. A No. 30 file is used to gauge the apical opening. Recapitulation with a
regular No. 30 instrument, followed by liberal irrigation, is most important. E, The flexibility and cutting ability of nickel-titanium ProTaper
Rotary Files are assets in preparing curved constricted canals. F, Triangular cross-section presents three sharp blade edges that improve cut-
ting ability and tactile sense. Reproduced with permission from ADVANCED ENDODONTICS video and Drs. John West and Clifford
Ruddle. (Color reproduction courtesy of Dentsply Tulsa Dental)
3. Establish a smooth glide path with No. 10 and No. ment is found to be snug, the preparation is finished.
15 stainless steel hand files. With the instrument in place, radiographically veri-
4. Use maximum magnification to observe the move- fy the exact length before final irrigation.
ment of the rotary instrument. Seeing rotary api- 7. If the F-1 and the No. 20 hand file are loose, contin-
cal movement is safer than simply feeling such ue the preparation with the Finisher F-2, which is
movement. 0.25 mm diameter at the tip. Confirm with a No. 25
5. Use a torque- and speed-controlled electric motor, hand instrument and, if snug, confirm the length
powering the handpiece at 200 to 300 rpm. radiographically, irrigate, and complete.
6. Be much gentler than with hand instruments. 8. If the F-2 instrument and the No. 25 hand file are
Always treat in a moist canal. Irrigate frequently! loose, continue the preparation to just short of the
7. Slow down! Each instrument should do minimal working length with the Finisher F-3 file, which has
shaping. Only two, three, or four passes may be a 0.30 mm tip diameter, and follow with the con-
required for the file to engage restrictive dentin and firming No. 30 instrument. If the No. 30 is found to
carve the shape to the proper depth. be snug, the preparation is finished (see Figure 10-
8. Instruments break when flutes become loaded or 89, D). If this is loose, there are a number of tech-
when instruments are forced. Check the flutes fre- niques to enlarge the apical third to larger sizes.
quently under magnification and clean them. Cyclic 9. Frequent irrigation and file cleansing are impera-
fatigue from overuse, or if the glide path is not well tiveirrigation and recapitulation!
established, also leads to breakage.
9. ProTaper instruments are disposable and, like all Now that the perfectly tapered preparation is com-
endodontic files and reamers, are designed for sin- plete, smear layer removal with EDTA and sodium
gle-patient use. Sometimes instruments are even hypochlorite is in order, followed by either medication
changed within the same treatment (eg, in the case and/or obturation.
of a four-canal molar).
10. Irrigate with 17% EDTA or a viscous chelator dur- Quantec System and Graduating Taper Technique
ing the ProTaper shaping. The Quantec Series (Sybron Endo/Analytic; Orange,
Calif.) consists of a series of 10 graduated nickel-titani-
um tapers from 0.02 through 0.06 with ISO tip siz-
ProTaper System: Directions for Use
ing507,518 (Figure 10-90). The Quantec Flare Series, with
1. Establish proper access and a glide path with No. 10 increased tapers of 0.08, 0.10, and 0.12, all with tip sizes
and No. 15 stainless steel files to the working length of ISO 25, are designed to quickly and safely shape the
or the apical constriction exit. coronal third of the canal. In contrast to the basic prin-
2. Flood the canal and chamber with sodium ciples of other rotary instrument techniques, this system
hypochlorite and begin shaping with the Shaper S-1 incorporates a built-in graduated tapers technique,
using multiple, passive-pressure passes. Go no deep- whereby a series of varying tapers are used to prepare a
er than three-quarters of the estimated canal length. single canal. The instruments are used at 300 to 350 rpm
Irrigate and recapitulate with a No. 10 hand file, in a high-torque, gear-reduction, slow-speed handpiece.
establishing patency to full working length. Now, Proponents of the graduating tapers technique
with S-1, extend the preparation to full working claim that, theoretically, using a series of files of a sin-
length. Again irrigate and recapitulate. gle taper, whether it is a conventional 0.02 taper or a
3. Brush with the Shaper S-X to improve the greater taper, will result in decreased efficiency as larg-
straight-line access in short teeth or to relocate canal er instruments are used, that is, more of the file comes
access away from furcations in posterior teeth. into contact with the dentinal walls, making it more
4. Shaping file S-2 is now used to full working length. difficult to remove dentin as forces are generated over a
Irrigate, recapitulate, and reirrigate. larger area.518 Ultimately, each instrument will become
5. Confirm and maintain working length with a hand fully engaged along the canal wall, potentially inhibit-
file. (Remember, as curves are straightened, canals ing proper cleaning and shaping of the apical canal.
are shortened.) In contrast and in accordance with the graduating
6. With Finisher F-1, passively extend the preparation tapers technique, by restricting the surface contact
to within 0.5 mm of the working length. Withdraw between instrument and wall, an instruments efficien-
after one second! And only one second! The F-1 has cy is increased since the forces used are concentrated on
a tip size of 0.20 mm, and if a No. 20 hand instru- a smaller area. In this technique, for example, once a
A B
Figure 10-90 A, The Quantec series of variably tapered instruments comes in both safe-cutting (SC) and noncutting (LX) tips and three
lengths: 17, 21, and 25 mm (see Figure 10-28). Quantec files are 30% shorter in the rotary handle, and when used in the Axxess Minihead
handpiece, over 5 mm of length are saved. B, Cross-section of the newest Sybronendo rotary file-K3. Note that three cutting blades have pos-
itive rakes that materially increase the cutting ability. Also note that the radial land relief reduces friction and provides debris collection space.
The nickel-titanium files come in 0.04 and 0.06 tapers, tip sizes ISO 10 to 60, and increasing variable helical flute angle from D1 to D16.
(Courtesy of SybronEndo.)
0.02 taper has shaped the canal, a 0.03 taper with the narrow curvatures, and calcified canal systems. This
same apical diameter would engage the canal more faceted 60-degree tip cuts as it moves apically; as the tip
coronally; by altering the taper from 0.02, to 0.03, and approaches a curve, conceptually, a balance takes place
up the scale to 0.06, the efficiency of canal preparation between file deflection and cutting. The LX noncutting
is maximized by restricting surface contact. tip, on the other hand, is a nonfaceted bullet-nosed tip,
The Quantec rotary instruments are uniquely engi- acting as a pilot in the canal and deflecting around severe
neered with slightly positive rake or blade angles on curvatures in less constricted canals (see Figure 10-28,
each of their twin flutes; these are designed to shave B). These LX Quantec instruments are also recommend-
rather than scrape dentin (negative rake angle), which ed for enlarging the body and coronal segments and
most conventional files do. Flute design also includes a managing delicate apical regions.
30-degree helical angle with flute space that becomes Canal Preparation. The Graduating Tapers technique
progressively larger distal to the cutting blade, helping involves a modified step-down sequence, starting with a
channel the debris coronally. More peripheral mass has larger tapered file first and progressing with files of lesser
been added to these files rather than depending on core taper until working length is achieved. The technique
strength alone as in other rotary systems. involves canal negotiation, canal shaping, and, finally, api-
Quantecs wide radial lands are purported to pre- cal preparation. As in all instrumentation techniques,
vent crack formation in the blades and aid in deflecting straight-line access to the canal orifices must be made first,
the instrument around curvatures. By recessing the followed by passive negotiation of the canal using No. 10
wide radial lands behind the blade, there is a concomi- and No. 15 0.02 taper hand files. A Quantec No. 25, 0.06
tant reduction in frictional resistance while maintain- taper, 17 mm in length, is passively used. In most cases, this
ing canal centering. instrument should approach the apical third of the canal;
With respect to tip geometry, the clinician has a at this point, the working length must be established.
choice of two designs. The SC safe-cutting tip (see Figure A Glide Path is now established for all subsequent
10-28, A) is specifically designed for small, tight canals, Quantec files by working No. 10 and No. 15 0.02 taper
hand files along with sodium hypochlorite to the estab- the head of the LightSpeed to a size larger than what
lished working length. During the shaping phase, each could normally be produced using tapered instruments.
Quantec file, progressing sequentially from a 0.12 taper Since taper adds metal and decreases both flexibility and
down to a 0.03 taper, is passively carried into the canal as tactile feel toward the more apical regions of the canal,
far as possible. In all cases, light apical pressure must be the LightSpeed instrument head, with its short cutting
applied, using a light pecking motion and never advanc- blades, only binds at its tip, thus increasing the accuracy
ing more than 1 mm per second into the canal. Each of the tactile feedback. This results in rounder and cen-
instrument should be used for no more than 3 to 5 sec- tered apical preparations.502,508,514,519521 Success with
onds. The sequence is repeated until a 0.06 or 0.05 taper the LightSpeed, however, is predicated on straight-line
reaches the working length. The apical preparation can access, an adequate coronal preflare, and establishment
then be deemed complete or further enlarged by using of working length prior to its introduction into a canal.
the Quantec standard 0.02 taper No. 40 or No. 45 rotary The LightSpeed instrument has a short cutting blade
instruments or hand files. with three flat radial lands, which keeps the instrument
With the Quantec series, the correct amount of api- from screwing into the canal, a noncutting pilot tip (see
cal pressure must be maintained at all times; the con- Figures 10-90 inset, and Figure 10-26), and a small-
tinuously rotating instrument should either be inserted diameter noncutting flexible shaft, which is smaller
or withdrawn from the canal while allowing for its slow than the blade and eliminates contact with the canal
apical progression. The instrument, however, should be wall. Laser-etched length control rings on the shaft
withdrawn after the desired depth has been reached eliminate the need for silicone stops (see Figure 10-90).
and not left in the canal for an extended period of time, The LightSpeed instrument has a cross-sectional U-
potentially causing canal transportation, ledge forma- blade design in which flat radial lands with neutral rake
tion, and instrument separation. Thus, to reduce pro- angles enhance planing of the canal walls and centering
cedural problems, there should always be a continuous of the instrument within the canal. The helical blade
apical/coronal movement of the instrument, and, if the angle and narrow shaft diameter facilitate debris
rotating file begins to make a clicking sound (file bind- removal coronally.
ing), one should withdraw the file and observe for Canal Preparation. Following proper coronal access,
instrument distortion. preflaring with Gates-Glidden drills or another method
is highly recommended. The working length must first be
LightSpeed Endodontic Instruments established with at least a No. 15 stainless steel K file.
The LightSpeed rotary instrumentation system Prior to using the LightSpeed in the handpiece, the clini-
(LightSpeed Technology; San Antonio, Tex.), so named cian should first select and hand-fit a No. 20 LightSpeed
because of the light touch needed as the speed of instrument that binds short of the working length. Once
instrumentation is increased, involves the use of spe-
cially engineered nickel-titanium Gates-Glidden-like
reamers (see Figure 10-90) that allow for enhanced tac-
tile control and apical preparations larger than those
created via conventional techniques and other nickel-
titanium rotary systems.502,508,514,519521 The set of
instruments consists of ISO-sized rotary files from size
20 through 100, including nine half-sizes ranging from
22.5 through 65. The half sizes help reduce stress on
both the instrument and root during preparation and
decrease the amount of cutting that each instrument
must accomplish. In most clinical cases, about 8 to 14
instruments are needed. They are used in a continuous,
360-degree clockwise rotation with very light apical
pressure in a slow-speed handpiece. The recommended
rpm is between 750 and 2,000, with preference toward
Figure 10-91 LightSpeed instrument. The head has a noncutting
the 1,300 to 2,000 range. tip and is the U-style design. Note the small cutting head and the
Owing to the flexible, slender, parallel shaft (Figure long noncontacting shaft, making the LightSpeed a unique instru-
10-91) that makes up the body of the instrument, the cli- ment, much like a Gates-Glidden in configuration. (Courtesy of
nician can prepare the apical portion of the canal with LightSpeed Technology.)
Canal Preparation. Once Gates-Glidden drills are instruments must be used with light apical pressure
used to prepare and shape the coronal region of the and never be forced and must always be used in a
canal in a step-down manner, and the canal has been at lubricated canal system to reduce frictional resistance,
least partially negotiated with hand files, Pow-R files preferably with RC-Prep or Glyde or another accept-
can be used. The clinician should select a file that binds able lubricant.
at its tip in the middle third and begin to gradually Abrupt curvatures, S-shaped canal systems, and
move and push that file as it is rotating, slightly with- canals that join must be avoided with any nickel-titani-
drawing it every 0.25 mm penetration until no more um rotary file; use of rotary files in these cases may also
than 2 mm of depth are achieved or until resistance is lead to breakage. When a nickel-titanium file rotates
felt. Like any other nickel-titanium file, these instru- inside any canal system, it becomes stressed and may
ments must be used passively and with a light touch or subsequently wobble in the handpiece once the
pecking motion. The working length should now be instrument is removed; the file should be disposed of.
determined using a hand file. Constant recapitulation As the nickel-titanium file experiences any undue
with hand files is the rule along with constant irriga- stress, including cyclic fatigue,514 the metal undergoes a
tion. The next smaller Pow-R file is used to continue crystalline (microscopic) phase transformation and
shaping an additional 1 to 2 mm deeper. Rotary instru- can become structurally weaker. In many cases, there is
mentation continues, decreasing sizes in sequence usually no visible or macroscopic indication that the
until the shaping is about 1.5 mm short of the apical metal has fatigued. With repeated sterilization,
foramen. The remaining portion of the canal can be Rapisarda et al. demonstrated decreased cutting effi-
finished with hand instruments or with Pow-R files. If ciency and alteration of the superficial structure of
more flare is needed, particularly if an obturation tech- Nickel-titanium ProFiles, thus indicating a weakened
nique that requires deep condenser penetration is con- structure, possibly prone to fracture.522 Essentially, a
sidered, a rotary incremental step-back can be used to nickel-titanium file may disarticulate without any
generate additional space in the apical and middle por- warning, especially if not properly used. Thus, it
tions of the canal. behooves the astute clinician to develop a systematic
Both the RBS files and Pow-R instruments are used method for recognizing potential problems (grabbing
in high-torque, gear-reduction handpieces with rpm or frictional locking of files into the canal, unwinding,
ranging from 300 to 400. twisting, cyclic fatigue, etc) and disposing of these
nickel-titanium instruments. No one knows the maxi-
Principles of Nickel-Titanium Rotary mum or ideal number of times that a nickel-titanium
Instrumentation file can be used.
Irrespective of the nickel-titanium system used, nickel- There is no doubt that the evolution of mechanized
titanium instruments are not designed for pathfinding, or rotary instrumentation using specially designed
negotiating small calcified or curved canals, or bypass- nickel-titanium files in gear-reduction, high-torque
ing ledges. Placing undue pressure on these extremely handpieces has revolutionized endodontics owing to
flexible instruments may lead to file breakage. This is their speed and efficacy in canal shaping and maintain-
attributable to the fact that nickel-titanium has less ing canal curvature. There is also no doubt that the
longitudinal strength and may deflect at a point where development of the shape-memory alloy, nickel titani-
pressure is off the file. As mentioned throughout this um, for use in endodontics has elevated the practice of
section, stainless steel instruments should be used ini- endodontics to a higher level. With the evolution of
tially for pathfinding owing to their enhanced stiffness. torque-control electric motors and the continual engi-
Once the canal has been negotiated with at least a stain- neering of more sophisticated instrument designs,
less steel No. 15 K-type file or a ledge has been bypassed cleaning and shaping with rotary instruments, made
and removed, then rotary nickel-titanium instruments with shape-memory alloys, may eventually become the
can be used. Stainless steel instruments are also more standard of care.
radiopaque than nickel-titanium and show up better
in tooth length measurements. LASER-ASSISTED CANAL PREPARATION
When using a gear-reduction, slow-speed, nickel- After the development of the ruby laser by Maiman in
titanium rotary handpiece, the clinician must always 1960, Stern and Sognnaes (1964) were the first investi-
keep the handpiece head aligned with the long axis of gators to look at the effects of ruby laser irradiation on
each canal as good straight-line access decreases exces- hard dental tissues.523 Early studies of the effects of
sive bending on the instrument. Nickel-titanium rotary lasers on hard dental tissues were based simply on the
empirical use of available lasers and an examination of discussed laser-endodontic therapy, some as supple-
the tissue modified by various techniques. mentary and others as a purely laser-assisted
Laser stands for Light Amplification by Stimulated method.527 Although the erbium:YAG (May 1997) and
Emission of Radiation, and it is characterized by being erbium:YSGG (October 1998) lasers were approved for
monochromatic (one color/one wavelength), coher- dental hard tissues, lasers still need to be approved by
ent, and unidirectional. These are specific qualities the US Food and Drug Administration (FDA)
that differentiate the laser light from, say, an incandes- Committee on Devices for intracanal irradiation. The
cent light bulb. FDAs clearance for these devices includes caries
For any procedures using lasers, the optical interac- removal and cavity preparation, as well as roughening
tions between the laser and the tissue must be thor- enamel. Other countries, such as Germany, Japan, and
oughly understood to ensure safe and effective treat- Brazil, have been conducting basic research and laser
ment. The laser-light interaction is controlled by the clinical trials, and some of the devices have been used
irradiation parameters, that is, the wavelength, the there for treatment.
repetition rate, the pulse energy of the laser, as well as
the optical properties of the tissue. Typically, optical Laser Endodontics
properties are characterized by the refraction index, In 1971, at the University of Southern California,
scattering (s), and absorption coefficients (a). Weichman and Johnson were probably the first
However, the ultimate effects of laser irradiation on researchers to suggest the use of lasers in endodontics.528
dental tissue depend on the distribution of energy A preliminary study was undertaken to attempt to ret-
deposited inside the tooth. Laser energy must be roseal the apical orifice of the root canal using an
absorbed by tissue to produce an effect. The tempera- Nd:YAG and a carbon-dioxide laser. Although the goal
ture rise is the fundamental effect determining the was not achieved, relevant data were obtained. In 1972,
extent of changes in the morphology and chemical Weichman et al. suggested the occurrence of chemical
structure of the irradiated tissue.524 and physical changes of irradiated dentin.529 The same
Lasers emitting in the ultraviolet, visible (ie, argon laser wavelengths were then used, with different materi-
laser488 and 514 nm), and near infrared (ie, als, in an attempt to seal internally the apical constriction.
neodymium:yttrium-aluminum-garnet [Nd:YAG] Applications of lasers in endodontic therapy have
laser1.064 m) are weakly absorbed by dental hard been aggressively investigated over the last two decades.
tissue, such as enamel and dentin, and light scattering According to Stabholz of Israel, there are three main
plays a very important role in determining the energy areas in endodontics for the use of lasers: (1) the peria-
distribution in the tissue. Nd:YAG laser energy, on the pex, (2) the root canal system, and (3) hard tissue,
other hand, interacts well with dark tissues and is mainly the dentin.530 One of the major concerns of
transmitted by water. Argon lasers are more effective on endodontic therapy is to extensively clean the root canal
pigmented or highly vascular tissues. to achieve necrotic tissue dbridement and disinfection.
Excimer lasers (193, 248, and 308 nm) and the In this sense, lasers are being used as a coadjuvant tool
erbium laser (~3.0 m) are strongly absorbed by den- in endodontic therapy, for bacterial reduction, and to
tal hard tissues. Neev et al. have shown that the excimer modify the root canal surface. The action of different
at 308 nm is efficiently absorbed by dentin since it types of laser irradiation on dental root canalsthe car-
overlaps protein absorption bands.525,526 The erbium bon-dioxide laser,531 the Nd:YAG laser,532 the argon
laser emits in the mid-infrared, which coincides with laser,533 the excimer laser,534 the holmium:YAG laser,535
one of the peaks of absorption of water and the OH- of the diode laser,536 and, more recently, the erbium:YAG
hydroxyapatite. Because of that, this laser is strongly laser537has been investigated.
absorbed by water, the absorbed energy induces a rapid Unlike the carbon-dioxide laser, the Nd:YAG (Figure
rise in temperature and pressure, and the heated mate- 10-93, A), argon, excimer, holmium, and erbium laser
rial is explosively removed. beams can be delivered through an optical fiber (Figure
The carbon-dioxide lasers emitting in the far infrared 10-93, B) that allows for better accessibility to different
(10.6 m) were among the first used experimentally for areas and structures in the oral cavity,530 including root
the ablation of dental hard tissues. The carbon-dioxide canals. The technique requires widening the root canal
laser is the most effective on tissues with high water con- by conventional methods before the laser probe can be
tent and is also well absorbed by hydroxyapatite. placed in the canal. The fibers diameter, used inside the
Studies have been conducted evaluating the effects canal space, ranges from 200 to 400 m, equivalent to a
of laser irradiation inside root canals. The authors have No. 20-40 file (Figure 10-93, C).
A C
Figure 10-93 A, Nd:YAG (1.06 m) laser device delivered by a quartz fiber optic200, 300, 320, and 400 m diameter fiber available. B,
Endo fiber (arrow) (285 and 375 m fiber available) and handpiece for the erbium:YAG laser. C, Radiograph of canine tooth with
Erbium:YAG fiber introduced into the root canal. (Courtesy of American Dental Technologies; Corpus Christi, Tex.)
Dederich et al., in 1984, used an Nd:YAG laser to optic at a stationary point, 1 mm from the apical fora-
irradiate the root canal walls and showed melted, men, for 2 to 3 seconds. Infiltration of inflammatory
recrystalized, and glazed surfaces.527 Bahcall et al., in cells was observed in all groups in 2 weeks, including
1992, investigated the use of the pulsed Nd:YAG laser to the control group. Indeed, the degree of inflammation
cleanse root canals.538 Their results showed that the reported in the laser-irradiated group at 2 weeks, 30 Hz
Nd:YAG laser may cause harm to the bone and peri- (0.67 mJ/p) for 2 seconds, was significantly less than in
odontal tissuesa good example that laser parameters the control group at 4 and 8 weeks. However, the same
should constitute one of the factors for safety and effi- authors have shown542 that carbonization was
cacy of laser treatment. observed in irradiated root canals depending on the
According to Levy532 and Goodis et al.,539 the parameter used. A technique considered optimal by
Nd:YAG, in combination with hand filing, is able to Gutknecht et al. would be the irradiation from apical to
produce a cleaner root canal with a general absence of coronal surface in a continuous, circling fashion.543
smear layer. The sealing depth of 4 m produced by the Different laser initiators (dyes to increase absorp-
Nd:YAG laser was reported by Liu et al.540 tion) with the Nd:YAG laser were tested by Zhang et
One concern for laser safety is the heat produced at al.544 Black ink was an effective initiator for this laser,
the irradiated root surface that may cause damage to but the root canal was inconsistently changed. It might
surrounding supporting tissue. Studies evaluating be a consequence of the lack of uniformity in the distri-
changes at the apical constriction and histopathologic bution of the ink or laser irradiation inside the canals.
analysis of the periapical tissues were presented by Under the scanning electron microscope (SEM),
Koba and associates.541,542 They maintained the fiber lased dentin showed different levels of canal dbride-
ment, including smear layer removal and morphologic lows a decrease in the risk of subsurface thermal dam-
changes, related to the energy level and repetition rate age since less energy is necessary to heat the surface.
used.545 There was no indication of cracking in all of The efficacy of argon laser irradiation in removing
the SEM samples at these laser parameters. The debris from the root canal system was evaluated by
erbium:YAG laser, at 80 mJ, 10 Hz, was more effective Moshonov et al.533 After cleaning and shaping, a 300 m
for debris removal (Figure 10-94, A), producing a fiber optic was introduced into the root canals of single-
cleaner surface with a higher number of open tubules rooted teeth to their working length. During irradiation,
when compared with the other laser treatment and the the fiber was then retrieved, from the apex to the orifice.
controlwithout laser treatment (Figure 10-94, B). A Scanning electron microscopic analysis revealed that sig-
decreased level was observed when the energy was nificantly more debris was removed from the lased
reduced from 80 to 40 mJ. Nd:YAG laser-irradiated group than from the control (Figure 10-95).
samples presented melted and recrystalized dentin and Although it appears that argon laser irradiation of
smear layer removal (Figure 10-94, C). the root canal system efficiently removes intracanal
The root canal walls irradiated by the erbium:YAG debris, its use as a treatment modality in endodontics
laser were free of debris, the smear layer was removed, requires further investigation. This is partially true
and the dentinal tubules were opened, as recently because this laser is emitted in a continuous mode
reported by Takeda et al.546,547 and Harashima et al.,548 like the carbon-dioxide laserin the range of millisec-
although areas covered by residual debris could be onds. This means that a longer period of interaction
found where the laser light did not enter into contact with the intracanal surface is required and, conse-
with the root canal surface.548 Scanning electron quently, a great increase in temperature.
microscopic evaluation showed different patterns as a One of the limitations of the laser treatment was
result of the different mechanisms of laser-tissue inter- demonstrated by Harashima et al.550 Where the
action by these two wavelengths.546548 (argon) laser optic fiber had not touched or reached
According to Hibst et al., the use of a highly the canal walls, areas with clean root canal surfaces
absorbed laser light, like the erbium laser, tends to were interspersed with areas covered by residual
localize heating to a thin layer at the sample surface, debris. Access into severely curved roots and the cost of
thus minimizing the absorption depth.549 There fol- the equipment are other limitations.
A B
Indications Technique
Pulp mummification with arsenic trioxide, formalde- The following are the steps in the performance of a
hyde, or other destructive compounds was at one time well-executed pulpectomy:
preferable to extirpation.560 With the advent of effec-
tive local anesthetics, pulpectomy has become a rela- 1. Obtain regional anesthesia.
tively painless process and superseded mummifica- 2. Prepare a minimal coronal opening and, with a
tion, with its attendant hazards of bone necrosis and sharp explorer, test the pulp for depth of anesthesia.
prolonged postoperative pain. 3. If necessary, inject anesthetic intrapulpally.
4. Complete the access cavity. begun. All pulp tissue that has not been removed by the
5. Excavate the coronal pulp. round bur should be eliminated with a sharp spoon
6. Extirpate the radicular pulp. excavator. The tissue is carefully curetted from the pulp
7. Control bleeding and dbride and shape the canal. horns and other ramifications of the chamber. Failure
8. Place medication or the final filling. to remove all tissue fragments from the pulp chamber
may result in later discoloration of the tooth. At this
Each of these steps must be completed carefully before point, the chamber should be irrigated well to remove
the next is begun, and each requires some explanation. blood and debris.
near the apical foramen will stop the flow of blood third of the canal, allowing for more efficient removal
and all pain sensations. At the same time, the needle of the pulp.
displaces the pulp tissue and creates the desired
pathway for a broach. Partial Pulpectomy
2. A broach, small enough not to bind in the canal, is When a partial pulpectomy is planned, a technique
passed to a point just short of the apex. The instru- described by Nygaard-stby (personal communica-
ment is rotated slowly, to engage the fibrous tissue in tion, 1963) is employed. From a good radiograph, the
the barbs of the broach, and then slowly withdrawn. width of the canal at the desired level of extirpation is
Hopefully, the entire pulp will be removed with the determined. A Hedstroem file of correct size is blunt-
broach (Figure 10-98, B). If not, the process is ed so that the flattened tip will bind in the canal at the
repeated. If the canal is large, it may be necessary to predetermined point of severance. The Hedstroem file
insert two or three broaches simultaneously to has deep fluting and makes a cleaner incision than
entwine the pulp on a sufficient number of barbs to other intracanal instruments. Enlargement of the
ensure its intact removal. canal coronal portion is then carried out with a series
3. If the pulp is not removed intact, small broaches are of larger instruments trimmed to the same length.
used to scrub the canal walls from the apex outward Neither Stromberg563 nor Pitt Ford564 was particu-
to remove adherent fragments. A word of caution: larly enthusiastic about healing following pulpectomy,
The barbed broach is a friable instrument and must either total or partial. Working with dogs, both were
never be locked into the canal. Handle with care! troubled by postoperative periradicular infections pos-
sibly induced by coronal microleakage. Pitt Ford con-
Small Canal, Total Pulpectomy sidered anachoresis the route of bacterial contamina-
If the canal is slender, and a total pulpectomy is indi- tion. Others have found, however, that intracanal infec-
cated, extirpation becomes part of canal preparation. A tions by anachoresis do not occur unless the periradic-
broach need not be used. Small files are preferred for ular tissues were traumatized with a file and bleeding
the initial instrumentation because they cut more was induced into the canal.565
quickly than reamers. In such a canal, Phase I instru-
mentation to a No. 25 file is usually minimal to remove Control of Bleeding and Dbridement of Canal
the apical pulp tissue (Figure 10-99). New rotary Incomplete pulpectomy will leave in the canal frag-
increased-tapered instruments open up the coronal ments of tissue that may remain vital if their blood
A B
Figure 10-99 A, Space between canal walls and No. 10 file demonstrates need to instrument the canal to at least file size No. 25 for total
pulpectomy. B, No. 25 instrument engaging walls and removing pulp. (Courtesy of Dr. Thomas P. Mullaney.)
supply is maintained through accessory foramina or endodontic therapy, a temporary pulpotomy can be
along deep fissures in the canal walls (Figure 10-100). performed in a relatively short period of time. In a busy
These remnants of the pulp may be a source of severe practice, where it may not be practical to complete
pain to the patient, who will return seeking relief as instrumentation at the emergency visit, a pulpotomy
soon as the anesthesia wears off. This is a desperately can be done. First, anesthetic solution is used to irrigate
painful condition and requires immediate reanestheti- the pulp chamber. The coronal pulp is then amputated
zation and extirpation of all tissue shreds. Any over- with a sharp excavator. A well-blotted Formocresol pel-
looked tissue will also interfere with proper obturation let may be sealed in with a suitable temporary. Some
during immediate filling procedures. advocate sealing in cotton alone, with no medication.
Persistent bleeding following extirpation is usually a The temporary pulpotomy will normally provide the
sign that tags of pulp tissue remain. If the flow of patient with relief until complete instrumentation can
blood is not stopped by scrubbing the canal walls with be carried out at a subsequent appointment. Swedish
a broach, as described above, it may originate in the dentists used this technique in 73 teeth with irre-
periradicular area. In these cases, it is best to dry the versible pulpitis and arrested toothache 96% of the
canal as much as possible after irrigating with anes- time. Three patients, however, had to return for total
thetic. A dry cotton pellet is then sealed in until a sub- pulpectomy for pain relief.566
sequent appointment.
Placement of Medication or Root Canal Filling
Emergency Pulpotomy If pulpectomy was necessitated by pulpitis resulting
Although complete pulpectomy is the ideal treatment from operative or accidental trauma, or planned
for an irreversibly inflamed vital pulp requiring extirpation of a normal pulp for restorative purposes
was done, cleaning and shaping and obturation of
the canal can be completed immediately. If a delay is
necessary, a drug of choice or dry cotton should be
sealed in the chamber. The final canal filling should
never be placed, however, unless all pulpal shreds are
removed and hemorrhage has stopped. Immediate
filling is contraindicated if the possibility of pulpal
infection exists.
INTRACANAL MEDICATION
Antibacterial agents such as calcium hydroxide are rec-
ommended for use in the root canal between appoint-
ments. While recognizing the fact that most irrigating
agents destroy significant numbers of bacteria during
canal dbridement, it is still thought good form to fur-
ther attempt canal sterilization between appointments.
The drugs recommended and technique used are thor-
oughly explored in chapter 3.
IATRAL ERRORS IN ENDODONTIC
CAVITY PREPARATION
For a description of the prevention and correction
of mishaps in endodontic cavity preparations, see
chapter 15.
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canals with the Roane technique. JOE 1987;10:479. 514. Pruett JP, Clement DJ, Carnes DL Jr. Cyclic fatigue testing of
492. Bachman CA, et al. A radiographic comparison of two root nickel-titanium endodontic instruments. JOE 1997;23:77.
canal instrumentation techniques. JOE 1992;18:19. 515. Kavanaugh D, Lumley PJ. An in vitro evaluation of canal
493. Roane JB. Presentation, American Association of Endodontics preparation using Profile .04 and .06 taper instruments.
Annual Meeting, Las Vegas, Nevada April 1990. Endod Dent Traumatol 1988;14:16.
494. Sabala CL, Roane JB, et al. Instrumentation of curved canals 516. Gabel WP, Hoen M, Steinman HR, et al. Effect of rotational
using a modified typed instrument: a comparison study. speed on nickel-titanium file distortion. JOE 1999;25:752.
JOE 1988;14:59. 517. Blum JY, Machtou P, Micallef JP. Location of contact areas on
495. McKendry DJ. A histologic evaluation of apical root canal rotary Profile instruments in relationship to the forces
debridement comparing two endodontic instrument tech- developed during mechanical preparation on extracted
niques [abstract]. JOE 1988;14:198. teeth. Int Endod J 1999;32:108.
496. McKendry DJ. Comparison of balanced forces, endosonic and 518. Schwartz FS, McSpadden JT. The Quantec rotary nickel titani-
step-back filing instrumentation techniques: quantification um instrumentation system. Endod Pract 1999;2:14.
of extruded apical debris. JOE 1990;16:24. 519. Tharuni SL, Parameswaran A, Sukumaran VG. A comparison
497. Swindle RB, et al. Effect of coronal-radicular flaring on apical of canal preparation using the K-file and LightSpeed in
transportation. JOE 1991;17:147. resin blocks. JOE 1996;22:474.
498. Charles TJ, Charles JE. The balanced force concept of instrumen- 520. Knowles KI, Ibarolla JL, Christiansen RK. Assessing apical
tation of curved canals revisited. Int Endod J 1998;31:166. deformation and transportation following the use of
499. Alacam T. Scanning electron microscope study comparing the LightSpeed root-canal instruments. Int Endod J
efficacy of endodontic irrigating systems. Int Endod J 1996;29:113.
1987;20:287. 521. Poulsen WB, Dove SG, del Rio CE. Effect of nickel-titanium
500. Jahde EM, et al. A comparison of short-term periradicular engine-driven instrument rotational speed on root canal
responses to hand and ultrasonic overextension during morphology. JOE 1995;21:609.
root canal instrumentation in the Macaca fascicularis mon- 522. Rapisarda E, Bonaccorso A, Tripi TR, Guido G. Effect of steril-
key. JOE 1987;13:388. ization on the cutting efficiency of rotary nickel-titanium
501. Mungel C, et al. The efficacy of step-down procedures during endodontic files. Oral Surg 1999;88:343.
endosonic instrumentation. JOE 1991;17:111. 523. Stern RH, Sognnaes RF. Laser beam effect on dental hard tis-
502. Glosson CR, Haller RH, Dove SB, del Rio CE. A comparison of sues [abstract]. J Dent Res 1964;43:873.
root canal preparations using NiTi engine-driven, and K- 524. Wigdor HA, Walsh JT, Featherstone JDB, et al. Lasers in den-
Flex endodontic instruments. JOE 1995;21:146. tistry. Laser Surg Med 1995;16:103.
503. Luiten D, Morgan L, Baumgartner C, Marshall JG. 525. Neev J, Liaw LL, Stabholz A, et al. Tissue alteration and ther-
Comparison of four instrumentation techniques on apical mal characteristics of excimer laser interaction with dentin.
canal transportation. JOE 1995;21:26. SPIE Proc 1992;1643:386.
504. Weine FS. The use of non-ISO-tapered instruments for canal 526. Neev J, Stabholz A, Liaw LL, et al. Scanning electron
flaring. Compend Dent Educ 1996;17:651. microscopy and thermal characteristics of dentin ablated
505. Bryant ST, Dummer PMH, Pitoni C, et al. Shaping ability of by a short pulsed XeCl excimer laser: Laser Surg Med
.04 and .06 taper ProFile rotary nickel-titanium instru- 1993;12:353.
ments in simulated root canals. Int Endod J 1999;32:155. 527. Dederich DN, Zakariasen KL, Tulip J. Scanning electron
506. Bryant ST, Thompson SA, Al-Omari MA, Dummer PMH. microscopic analysis of canal wall dentin. JOE 1984;10:428.
Shaping ability of Profile rotary nickel titanium instru- 528. Weichman JA, Johnson FM. Laser use in endodontics. A pre-
ments with ISO sized tips in simulated root canals. Part 1. liminary investigation. Oral Surg 1971;31:416.
Int Endod J 1998;31:275. 529. Weichman JA, Johnson FM, Nitta LK. Laser use in endodon-
507. Thompson SA, Dummer PMH. Shaping ability of Quantec tics. Part II. Oral Surg 1972;34:828.
Series 2000 rotary nickel-titanium instruments in simulat- 530. Stabholz A. Lasers in endodontics. In: Proceedings 6th
ed root canals: part 1. Int Endod J 1998;31:259. International Congress on Lasers in Dentistry, Maui,
508. Thompson SA, Dummer PMH. Shaping ability of LightSpeed Hawaii, July 2831, 1998. p. 7.
rotary nickel-titanium instruments in simulated root 531. Zackariasen KL, Dederich DN, Tulip J, et al. Bacterial action of
canals: part 1, Int Endod J 1997;23:698. carbon dioxide laser irradiation in experimental dental
509. Thompson SA, Dummer PMH. Shaping ability of Profile .04 root canals. Can J Microbiol 1986;32:942.
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ulated root canals. Part 1. Int Endod J 1997;30:1. laser beam: a comparative study. JOE 1992;18:123.
510. Thompson SA, Dummer PMH. Shaping ability of Profile .04 533. Moshonov J, Sion A, Kasirer J, et al. Efficacy of argon laser irra-
taper Series 29 rotary nickel-titanium instruments in sim- diation in removing intracanal debris. Oral Surg
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534. Pini R, Salimbeni R, Vannini M, Barone R. Laser dentistry: a 549. Hibst R, Stock K, Gall R, Keller U. ErYAG laser for endodontics
new application of excimer in root canal therapy. Laser efficiency and safety. In: Wigdor H, Featherstone JDB,
Surg Med 1989;9:352. Rechmann P, editors. Lasers in dentistry II. Proc SPIE
535. Nuebler-Moritz M, Gutknecht N, Sailer HF, Hering P, Prettl W. 1997;3192:14.
Laboratory investigation of the efficacy of holmium:YAG 550. Harashima T, Takeda FH, Kimura EJN, Matsumoto K. Effect of
laser irradiation in removing intracanal debris. In: Wigdor argon laser irradiation on instrumented root canal walls.
HA, Featherstone JDB, Rechmann P, editors. Lasers in den- Endod Dent Traumatol 1998;14:26.
tistry III. Proc SPIE 1997;2973:150. 551. Stabholz A, Neev J, Liaw LHL, et al. Sealing of human dentinal
536. Moritz A, Gutknecht N, Goharkhay K, et al. In vitro irradia- tubules by Xe-Cl 308-nm excimer laser. JOE 1993;19:267.
tion of infected root canals with a diode laser: results of 552. Hennig T, Rechmann P, Hadding U. Influences of 2nd har-
microbiologic, infrared spectrometric, and stain penetra- monic alexandrite laser radiation on bacteria. In:
tion examinations. Quintessence Int 1997;28:205. Proceedings 6th International Congress on Lasers in
537. Mehl A, Folwaczny M, Haffner C, Hickel R. Bactericidal effects Dentistry, Maui, Hawaii, July 2831, 1998. p. 225.
of 2.94 m Er:YAG laser radiation in dental root canals. 553. White JM, Goodis HE, Cohen JN. Bacterial reduction of con-
JOE 1999;25:490. taminated dentin by Nd:YAG laser [abstract]. J Dent Res
538. Bahcall J, Howard HA, Miserendino L, Walia H. Preliminary 1991;70:412.
investigation of the histological effects of laser endodontic 554. Stabholz A, Kettering J, Neev J, Torabinejad M. Effects of the
treatment on the periradicular tissues in dogs. JOE XeCl excimer laser on Streptococcus mutans. JOE
1992;18:47. 1993;19:232.
539. Goodis HE, White JM, Marshall SJ, Marshall GW. Scanning elec- 555. Gutknecht N, Moritz A, Conrads G, et al. Bacterial effect of
tron microscopic examination of intracanal wall dentin: ver- Nd:YAG laser in in vitro root canals. J Clin Laser Med Surg
sus laser treatment. Scanning Microsc 1993;7:979. 1996;14:77.
540. Liu HC, Lin CP, Lan WH. Sealing depth of Nd:YAG laser on 556. Gutknecht N, Nuebler-Moritz M, Burghardt SF, Lampert F.
human dentinal tubules. JOE 1997;23:691. The efficiency of root canal disinfection using a holmi-
541. Koba K, Kimura Y, Matsumoto K, et al. A histopathological um:yttrium-alumimium-garnet laser in vitro. J Clin Laser
study of the morphological changes at the apical seat and Med Surg 1997;15:75.
in the periapical region after irradiation with a pulsed 557. Gouw-Soares SC. Avaliacao bacteriana em dentina radicular
Nd:YAG laser. Int Endod J 1998;31:415. contaminada irradiada com laser de Ho:YAG. Estudo in
542. Koba K, Kimura Y, Matsumoto K, et al. A histological study of vitro [thesis]. Sao Paulo (Brazil): Faculdade de
the effects of pulsed Nd:YAG laser irradiation on infected Odontologia da Universidade de Sao Paulo; 1998.
root canal in dogs. JOE 1999;25:151. 558. Lussi A, Nussbacher U, Grosrey J. A novel non-instrumented
543. Gutknecht N, Kaiser F, Hassan A, Lampert F. Long-term clini- technique of cleansing the root canal system. JOE
cal evaluation of endodontically treated teeth by Nd:YAG 1993;19:549.
lasers. J Clin Laser Med Surg 1996;14(1):7. 559. Lussi A, Portman P, Nussbacher U, et al. Comparison of two
544. Zhang C, Kimura Y, Matsumoto K, et al. Effects of pulsed lased devices for root canal cleansing by the noninstrumentation
Nd:YAG laser irradiation on root canal wall dentin with technology. JOE 1999;25:9.
different lasers initiators. JOE 1998;24:352. 560. McQuillen JH. Dr. Maynards method of extirpating the pulp.
545. Cecchini SCM, Zezell DM, Bachmann L, et al. Evaluation of Dent Cosmos 1860;1:312.
two laser systems for intracanal irradiation. In: 561. Bohannan HM, Abrams L. Intentional vital pulp extirpation
Featherstone JDB, Rechmann P, Fried D, editors. Lasers in for prosthesis. J Prosthet Dent 1961;11:781.
dentistry V. Proc SPIE 1999;3593:31. 562. McQuillen JH. Review of dental literature and art: Who first
546. Takeda FH, Harashima T, Kimura Y, Matsumoto K. The mor- filled nerve cavities? Dent Cosmos 1862;3:556.
phological study of root canal walls with Er:YAG laser irra- 563. Stromberg T. Wound healing after total pulpectomy in dogs.
diation in removing debris and smear layer on root canal Odontol Revy 1969;20:147.
walls. JOE 1998;24:548. 564. Pitt Ford TR. Vital pulpectomyan unpredictable procedure.
547. Takeda FH, Harashima T, Eto JN, et al. Effect of Er:YAG laser Int Endod J 1982;15:121.
treatment on the root canal walls of human teeth: an SEM 565. Delivarris PD, Fan VSC. The localization of blood-borne bac-
study. Endod Dent Traumatol 1998;14:270. teria in instrumented unfilled and overinstrumented
548. Harashima T, Takeda FH, Kimura EJN, Matsumoto K. Effect of canals. JOE 1984;10:521.
Nd: YAG laser irradiation for removal of intercanal debris 566. Hasselgren G, Reit C. Emergency pulpotomy: pain relieving
and smear layer extracted human teeth. Jour of Clin Laser effect with and without the use of sedative dressing. JOE
Med and Surg. 1997;15:131. 1989;15:254.
Chapter 11
OBTURATION OF
THE RADICULAR SPACE
John I. Ingle, Carl W. Newton, John D. West, James L. Gutmann,
Gerald N. Glickman, Barry H. Korzon, and Howard Martin
The Washington Study of endodontic success and fail- physiochemical irritant to produce the periradicular
ure suggests percolation of periradicular exudate into inflammation of apical periodontitis.
the incompletely filled canal as the greatest cause of Such a sequence of events might well explain the
endodontic failure. Nearly 60% of the failures in the paradox of the periradicular lesion associated with a
study were apparently caused by incomplete oblitera- noninfected pulpless tooth. Periradicular inflamma-
tion of the radicular space (see chapter 13).
Dow and Ingle demonstrated in vitro the possibility
of apical percolation using a radioactive isotope.1 After
filling the root canals of extracted teeth, they placed the
teeth in radioactive iodine (131I). In teeth with a
fluid-tight seal of the apical foramen and a well-oblit-
erated canal space, there was no penetration of the
radioactive iodine (Figure 11-1, A). In the poorly filled
canalsfilled so by designa deep penetration into
the canal by 131I was apparent in the radioautographs
(Figure 11-1, B).
On the basis of this study, one might hypothesize
that the penetration of radioactive iodine into a
poorly filled root canal in vitro is analogous to fluid
percolation into the canal of in situ pulpless teeth
with incomplete canal obliteration (Figure 11-2).
Apical percolation may be considered a logical
hypothesis. However, the role of the end products of
microleakage in the production of periradicular
inflammation is open to speculation. It would seem
safe to assume that the noxious products leaking
from the apical foramen act as an inflammatory irri-
tant. The unanswered question concerns the produc-
tion of irritants in the canal. It is presently speculat-
ed that the transudate constantly leaking into the
unfilled or partially filled canal arises indirectly from A B
the blood serum and consists of a number of
water-soluble proteins, enzymes, and salts. It is fur- Figure 11-1 A, Failure of radioactive iodine (131I) to penetrate
ther speculated that the serum is trapped in the into well-filled canal. Only periradicular cementum that was not
coated with sticky wax has absorbed isotope. B, Massive reaction to
cul-de-sac of the poorly filled canal, away from the penetration of radioactive iodine (131I) into poorly filled canal.
influences of the bloodstream, and undergoes degra- Violent response at periapex is comparable to in vivo response to
dation there. Later, when the degraded serum slowly toxic canal products. Reproduced with permission from Dow PR
diffuses out to the periradicular tissue, it acts as a and Ingle JI.1
Figure 11-3 Ideal termination of canal preparation and obturation. A, Apical constriction at cementodentinal junction marks end of root
canal. From this point to anatomic apex (0.5 to 0.7 mm), tissue is periodontal. B, Photomicrograph of periapex. Small arrows at cemento-
dentinal junction. Large arrow (bottom) at denticle inclusion. A reproduced with permission from Goerig AC. In: Besner E, et al, editors.
Practical endodontics. St. Louis: CV Mosby; 1993. p. 46. B reproduced with permission from Brynolf I. Odontol Revy 1967;18 Suppl. 11.
Figure 11-4 Instrumentation and root canal filling beyond apical Figure 11-5 Periradicular puff (arrows) at four portals of exit,
limitation. Minor inflammatory and foreign body reaction has devel- maxillary premolar, provides assurance that canals are filled.
oped in response to irritant. (Courtesy of Dr. Seiichi Matsumiya.)
preparation and that all of the aberrations, as well as the solid-core filling materials, are eventually tolerated by
lateral and accessory canals of the root canal system, the periradicular tissues once the cements have set. The
have been cleansed and filled. No accounting is given of tissue reaction that does occur can be a fibrous walling
postoperative discomfort. In any case, overfilled canals off of the foreign body (Figure 11-7). On the other
tend to cause more postoperative discomfort than do hand, fewer stormy postoperative reactions can be
those filled to the dentinocemental junction. expected if canal instrumentation and filling are limit-
Many authors believe that filling just short of the ed by the narrowest waist of the apical foramen.
radiographic apex is greatly preferred to overfilling.
Filling short of the apex following pulpectomy is espe- WHEN TO OBTURATE THE CANAL
cially recommended by Nygaard-stby,32 Blayney,33 The root canal is ready to be filled when the canal is
and most recently Strindberg.34 Horsted and cleaned and shaped to an optimum size and dryness.
Nygaard-stby reported on pulpectomies of 20 vital Many feel that the smear layer lining the canal walls
human teeth, stating that the space between the should also be removed. The tooth should be comfort-
gutta-percha-Kloropercha fillings and the tissue surface able. Dry canals may be obtained with absorbent points
was filled by new connective tissue within a few except in cases of apical periodontitis or apical cyst, in
months.35 They claimed the same results with clinically which weeping into the canal persists.
healthy and chronically inflamed pulps (Figure 11-6). The exception to the aforementioned criteria is the
The University of Washington study also found no fail- case in which mild discomfort persists. Experience has
ures among those well-obliterated cases in which the shown that filling the root canal in such cases usually
filling terminated slightly short of the apex, whereas alleviates the symptoms. However, filling a root canal
3.85% of the failures were caused by overfilling. known to be infected is risky. Ingle and Zeldow have
Despite all of this, a high degree of success is still described the increase in postoperative discomfort
achieved if overfilling occurs. Fortunately, most of the from filling infected root canals.36 They also have
root canal sealers currently used, as well as the shown that the degree of success in a group of infected
cases was 11.2% less than that in an a priori group of
cases with negative bacteriologic cultures.37 More
Figure 11-6 Partial pulpectomy adequately obliterated to point of Figure 11-7 Tissue reaction to foreign body such as gutta-percha.
amputation. Even though root canal filling is short of apex, perfect (Courtesy of Dr. S.N. Bhaskar and US Army Institute of Pathology.)
healing has developed, as evidenced by normal pulp and periradic-
ular tissue. (Courtesy of Dr. Seiichi Matsumiya.)
recently, Sjgren and his associates in Sweden found gutta-percha escaped notice as a practical product for
that, after 5 years, 94% of those cases exhibiting nega- nearly 200 years. The first successful use of the curious
tive cultures at the time they were filled were com- material seems to have been as insulation for undersea
pletely successful. In marked contrast, only 68% of the cables. This was in 1848, and patents followed for its
cases filled with positive cultures were successful after use in the manufacture of corks, cement thread, surgi-
5 years, a 26% difference in success rate.38 cal instruments, garments, pipes, and sheathing for
ships. Some boats were made entirely of gutta-percha.
MATERIALS USED IN OBTURATION Gutta-percha golf balls were introduced by the latter
The materials used to fill root canals have been legion, part of the nineteenth century; until 1920, golf balls
running the gamut from gold to feathers. Grossman were called gutties. Gutta-percha has been known to
grouped acceptable filling materials into plastics, dentistry for over 100 years.40
solids, cements, and pastes.39 He also delineated 10 Actually, true gutta-percha may not be the product
requirements for an ideal root canal filling material presently supplied to the dental profession.
that apply equally to metals, plastics, and cements: Manufacturers privately admit they have long used bal-
ata, which is the dried juice of the Brazilian trees
1. It should be easily introduced into a root canal. Manilkara bidentata, of the sapodilla family. Gutta-per-
2. It should seal the canal laterally as well as apically. cha also comes from the sapodilla family, but from
3. It should not shrink after being inserted. Malaysian trees, genera Payena or Palaquium.
4. It should be impervious to moisture. Chemically and physically, balata and gutta-percha
5. It should be bacteriostatic or at least not encourage appear to be essentially identical; investigators in this
bacterial growth. field may have been given balata to test and told it was
6. It should be radiopaque. gutta-percha. In any event, the point appears to be
7. It should not stain tooth structure. moot, and either product is here called gutta-percha.
8. It should not irritate periradicular tissue. Chemically pure gutta-percha (or balata) exists in
9. It should be sterile or easily and quickly sterilized two distinctly different crystalline forms (alpha and
immediately before insertion. beta) that can be converted into each other. The alpha
10. It should be removed easily from the root canal if form comes directly from the tree. Most commercial
necessary. gutta-percha, however, is the beta crystalline form.40
There are few differences in physical properties between
Both gutta-percha and silver points meet these the two forms, merely a difference in the crystalline lat-
requirements. If the gutta-percha point has a fault, it tice depending on the annealing and/or drawing process
lies in its inherent plasticity, for it requires special han- used when manufacturing the final product.41
dling to position it. The major fault with the silver Traditionally, the beta form of gutta-percha was
point is its lack of plasticityits inability to be com- used to manufacture endodontic gutta-percha points
pacted. Both must be cemented into place, however, to to achieve an improved stability and hardness and
be effective. reduce stickiness. However, through special processing
and/or modifications to the formulation of the gutta-
Solid-Core Materials percha compound, more alpha-like forms of gutta-per-
Gutta-percha is by far the most universally used cha have been introduced, resulting in changes in the
solid-core root canal filling material and may be classi- melting point, viscosity, and tackiness of the gutta-per-
fied as a plastic. To date, modern plastics have been dis- cha point. Gutta-percha with low viscosity will flow
appointing as solid-core endodontic filling materials. with less pressure or stress,42 while an increase in tack-
However, new plastics are on the horizon. Silver amal- iness will help create a more homogeneous filling.
gam, used in the retrosurgical technique wherein the Various manufacturers have introduced products to
canal is filled from the apex, must also be considered a take advantage of these properties (eg, Thermafil,
plastic filling material. Densfil, Microseal).
The effect of heating on the volumetric change of
Gutta-percha gutta-percha is most important to dentistry. Gutta-per-
Because modern petrochemical plastics have proved so cha expands slightly on heating, a desirable trait for an
disappointing for canal obturation, a new interest has endodontic filling material.43 This physical property
developed in old-fashioned gutta-percha. First shown manifests itself as an increased volume of material that
as a curiosity in the mid-seventeenth century, may be compacted into a root canal cavity. Volumetric
studies show that it is possible to overfill a root canal cha and wax) and 76.4% inorganic fillers (zinc oxide and
preparation when heat and vertical condensation are barium sulfate).49 High zinc oxide levels were found to
applied because the volume of the gutta-percha filling increase brittleness in the points and decrease tensile
is greater than the space it occupies.44 strength. These percentages of composition essentially
Although the material is thought to be compressed have been confirmed by a French group. However, they
with force that would reduce its volume, studies have found that it is the high content of gutta-percha in the
shown that it is actually compacted, not compressed,45 points that results in their brittleness.50
and increased volumetric changes are due to heating. Gutta-percha points also become brittle as they age,
Unfortunately, warmed gutta-percha also shrinks as probably through oxidation.51 Storage under artificial
it returns to body temperature. Schilder et al. therefore light also speeds their rate of deterioration.52 On the
recommend that vertical pressure be applied in all other hand, they can be rejuvenated somewhat by alter-
warm gutta-percha techniques to compensate for vol- nate heating and cooling.53
ume changes that occur as cooling takes place.46 Evidence of slight antibacterial activity from gutta-
Camps et al. found that, even though warm gutta-per- percha points exists54; however, it is too weak to be an
cha is easily compacted, the plugger must be intro- effective microbiocide. As the destruction of bacteria is
duced apically since permanent deformation is under- key to endodontic success, a new formulation of gutta-
gone only after a 50% reduction in volume.47 This con- percha that contains iodoform, Medicated Gutta-
trasts with the use of cold gutta-percha in which an Percha (MGP) (Medidenta, Woodside, N.Y.), has been
important pressure must be applied to obtain perma- developed by Martin and Martin.55 Within the filled
nent deformation, but the spreaders do not have to be root canal, the iodine/iodoform depot in the MGP cone
introduced apically since a 6% deformation is already is a biologically active source for inhibiting microbial
permanent. Although techniques of gutta-percha growth. The iodoform is centrally located within the
placement involving heating in the root canal caused gutta-percha and takes about 24 hours to leach to the
reversible physical changes, no apparent changes in surface. The iodoform remains inert until it comes in
chemical composition take place.48 contact with tissue fluids that activate the free iodine.55
Studies of pure gutta-percha are actually rather A canal filled with MGP gutta-percha could serve as a
meaningless because endodontic gutta-percha contains protection against bacterial contamination from coro-
only a fraction of gutta-percha per se. A study at nal microleakage reaching the apical tissue. The use of
Northwestern University49 of the chemistry of heat during obturation does not affect either the release
gutta-percha filling points supplied by five manufactur- of the iodoform or its chemical composition.
ers found only about 20% of the chemical composition Gutta-percha cones have also been introduced that
to be gutta-percha, whereas the 60 to 75% of the com- contain a high percentage of calcium hydroxide
position is zinc oxide filler (Table 11-1). The remaining (4060%) (Roeko) to permit simple placement of the
constituents are wax or resin to make the point more pli- medicament within the canal space between appoint-
able and/or compactible and metal salts to lend ments. Once the calcium hydroxide has leached out, the
radiopacity. On an organic versus inorganic basis, point is no longer useful as a filling material and must
gutta-percha points are only 23.1% organic (gutta-per- be removed. Holland et al. have reported on the use of
Table 11-1 Mean (x- ) and Standard Deviation (SD) of Percentage Weights from Chemical Assay of the
Gutta-percha Endodontic Filling Materials
Gutta-percha Wax and/or Resin Metal Sulfates Zinc Oxide
Brand x- SD x- SD x- SD x- SD
Configuration
Gutta-percha points (or cones) are supplied in two
shapes. The traditional form is cone shaped to con-
form to the perceived shape of the root canal. Today
these cones are preferred by dentists who use the warm
gutta-percha/vertical compaction technique of filling.
Also, because the original spreaders used in the lateral
compaction technique were shaped to match these
cone shapes and sizes, traditional cones have long been
used as the accessory cones in the lateral compaction
technique. B
The other shape of gutta-percha points is standard- Figure 11-8 A, Five different brands of standardized gutta-percha
ized to the same size and shape as the standardized points showing irregularities in apical one third of tip. B, Three dif-
(ISO) endodontic instruments. These points are avail- ferent brands of standardized gutta-percha points of same size
able in the standardized .02 taper as well as in increased showing irregularities that produce variations in tip caliber.
Reproduced with permission from Goldberg F et al.60
taper sizes (.04, .06, etc) to correspond to the newer
tapered instrument sizes. Color coding the numbered
points to match ISO instrument color has become rou- well-calcified round tapered canals: maxillary first pre-
tine and it is now rare to find the standardized points molars with two or three canals, or the buccal roots of
without these convenient markings (N. Lenz, personal mature maxillary molars and mesial roots of mandibu-
communication). Although gutta-percha points are lar molars if they are straight. In youngsters, even these
supposed to be standardized according to instrument canals are too large and too ovoid for single silver point
size, a startling lack of uniformity has been found,59 as use. Silver points are also not indicated for filling ante-
well as an alarming degree of deformation of the points rior teeth, single canal premolars, or large single canals
in their apical third60 (Figure 11-8). in molars.
Before being used for root canal filling, gutta-percha Silver points often fail when used outside these situ-
points should be free of pathogenic microorganisms. ations (Figure 11-9). These failures in judgment have
Siqueira et al. studied four commonly used disinfec- given silver points a bad name. Seltzer and colleagues
tants and found that only 5.25% sodium hypochlorite have dramatically shown that failed silver points are
was effective in eliminating Bacillus subtilis spores from always black and corroded when removed from the
gutta-percha cones after 1 minute of contact. canal.62 Goldberg has further noted that corrosion may
Glutaraldehyde, chlorhexidine, and ethyl alcohol did be observed microscopically in cases previously judged
not decontaminate the gutta-percha points even after to be successful by clinical and radiographic criteria.63
10 minutes of contact.61 Kehoe reported a case of localized argyia of the buccal
gingiva, a dark-blue pigmented tattoo surrounded by
Silver a gray halo (Figure 11-9, C), related to severe corrosion
Silver points are the most widely used solid-core metal- of a failing silver point64 (Figure 11-9, D).
lic filling material, although points of gold, iridioplat- Gutierrez and his associates in Chile found that
inum, and tantalum are also available. Silver points canal irrigants corrode silver points.65 Brady and del
may be indicated in mature teeth with small or Rio reported that sulfur and chlorides were detected by
D
Figure 11-9 Root canal filling failure after 20 years. A, Silver point incorrectly used in mandibular premolar. Pain and swelling were first
indications of periradicular inflammation. B, Electron photomicrograph (300 original magnification) of corroded silver point removed
from canal seen in A. Moisture and decomposed cement were found in canal as well. C, Dark blue-pigmented lesion (argyria) surrounded
by gray halo caused by leakage from silver point corrosion. D, Corroded silver point removed from lingual canal in C 10 years after inser-
tion. (Electron photomicrograph, B, courtesy of Samuel Seltzer). C and D reproduced with permission from Kehoe JC.64
microanalysis of failed corroded points.66 Possibly the only cement depended on is a flashing between the
corrosion begins from within the canal, an aftermath of silver and the dentin wall. Silver has more rigidity than
apical microleakage. gutta-percha and hence can be pushed into tightly fit-
From such studies and a good deal of clinical evi- ting canals and around curves where it is difficult to
dence, the assumption has developed that silver points force gutta-percha. In an effort to avoid the problems
always corrode. This need not be true if the round inherent in silver points, yet make use of their versatil-
tapered point truly fits the round tapered cavity, sealing ity, Messing suggested that points be made of titani-
the foramen as a cork seals a bottle (Figure 11-10). The um.67 After 3 years, Messing, using titanium, reported
A B
Figure 11-10 Silver point removed from palatal canal of successfully treated molar, 7 years after treatment. No corrosive deposits are appar-
ent. A, 60 original magnification; B, 600 original magnification. Reproduced with permission from Seltzer S et al.62
three failures caused by excessive canal curvature and 12. It should not provoke an immune response in peri-
tear-drop (zip) perforations with leakage, cases radicular tissue.6972
contraindicated for either titanium or silver.67 13. It should be neither mutagenic nor carcino-
genic.73,74
Sealers
In addition to the basic requirements for a solid filling
material, Grossman listed 11 requirements and charac- Unfortunately, zinc oxideeugenol (ZOE) paste and
teristics of a good root canal sealer68: ZOE paste modified with paraformaldehyde have been
found to alter dog pulp tissue, making it antigenetical-
1. It should be tacky when mixed to provide good ly active.75 Epoxy resin sealer (AH-26), on the other
adhesion between it and the canal wall when set. hand, does not produce any systemic antibody forma-
2. It should make a hermetic [sic] seal. tion or delayed hypersensitivity reaction.72
3. It should be radiopaque so that it can be visualized As far as mutagenicity and carcinogenicity are con-
in the radiograph. cerned, Harnden73 reported that eugenol and its
4. The particles of powder should be very fine so that metabolites, although suspect, were uniformly negative
they can mix easily with the liquid. in a bacterial mutagenicity test; hence the probability
5. It should not shrink upon setting. that eugenol is a carcinogen is relatively low.
6. It should not stain tooth structure. Formaldehyde, formalin, and paraformaldehyde, on
7. It should be bacteriostatic or at least not encourage the other hand, are highly suspect. The US Consumer
bacterial growth. Product Safety Commission has issued warnings
8. It should set slowly. about the hazards of formaldehyde75 following a study
9. It should be insoluble in tissue fluids. on the subject by the National Academy of Sciences.76
10. It should be tissue tolerant, that is, nonirritating to In regard to some of the other 11 requirements orig-
periradicular tissue. inally elucidated by Grossman,68 it can be said that only
11. It should be soluble in a common solvent if it is nec- polycarboxylates and glass ionomers satisfy require-
essary to remove the root canal filling.
ment No. 1, good adhesion to dentin.77 Newer adhe-
One might add the following to Grossmans 11 basic sives are being tested at this time, however, and some
requirements: appear promising.
As far as requirement No. 2, the hermetic sic seal, is grey and that crowns filled with IRM and Dycal
concerned, the literature is replete with evaluations of became somewhat darker. No discolorations were
sealing effectiveness, many of them contradictory, and recorded for teeth filled with Durelon, Fuji glass
virtually all questionable as to their validity.7880 This is ionomer, Fletchers cement, or zinc phosphate
discussed later in the chapter. cement.87 Sealers that contain silver as a radiopacifier,
Radiopacity, requirement No. 3, is provided by salts such as Kerrs Root Canal Sealer (Rickerts Formula) or
of heavy metals and a halogen: lead, silver, barium, bis- the original AH-26, are notorious as tooth stainers. All
muth, or iodine. Beyer-Olsen and Orstavik measured in all, it seems wise to avoid leaving any sealers or stain-
the radiopacity of 409 root canal sealers and concluded ing cements in the tooth crown.
that it would be difficult to compare radiographically Grossman himself investigated the significance of
the quality of root filling when such a variance exists in his requirement No. 7, bacteriostatic effect of sealers.88
radiopacifiers.81 After testing 11 root canal cements, he concluded that
Requirement No. 4, dealing with particle size, was they all exerted antimicrobial activity to a varying
also investigated by Orstavik, who found sealer film degree, those containing paraformaldehyde to a
thicknesses, after mixing, ranging from 49 to 180 m.82 greater degree initially. With time, however, this latter
There was no apparent correlation, however, between activity diminished, so that after 7 to 10 days the
particle size and film thickness. He did point out the formaldehyde cements were no more bactericidal than
problems encountered with a thick film and proper the other cements.
sealing of the primary gutta-percha point. He found A British group studying the antibacterial activity
that some sealers may prevent reinsertion of a of four restorative materials reached much the same
gutta-percha point to its correct prefitted position.82 conclusion regarding ZOE and glass ionomer
Requirement No. 5, It should not shrink upon set- cements.89 Another study found that 10 sealers inhib-
ting, is notoriously violated if a canal is filled with ited growth of Streptococcus sanguis and Streptococcus
gutta-percha dissolved in chloroform. Whatever the mutans.90 A Temple University study found that
volume of the chloroform in the mixture, that will be Grossmans Sealer had the greatest overall antibacter-
the percentage of shrinkage as the chloroform gradual- ial activity, but that AH-26 was the most active against
ly evaporates.83 Moreover, all of the sealers shrink Bacteroides endodontalis, an anaerobe.91 Heling and
slightly on setting, and gutta-percha also shrinks when Chandler, at Hebrew University, also found AH26,
returning from a warmed or plasticized state. At the within dentinal tubules, to have the strongest antimi-
University of Connecticut Kazemi et al. found that crobial effect over three other well-known sealers.92
ZOE sealers begin shrinking within hours after mix- The Dundee University group, working with anaer-
ing but that AH-26first expanded and showed no obes, found, in descending order of antimicrobial
shrinkage for 30 days. They concluded that significant activity, Roth Sealer (Grossmans) to be the best, fol-
dimensional change and continued volume loss can lowed by Ketac-Endo, Tubliseal, Apexit, and
occur in some endodontic sealers.84 Sealapex.93 Mickel and Wright also found Roth Sealer
The admonition that sealers and filling materials to be more bactericidal than the calcium hydroxide
should not stain tooth structure, Grossmans require- sealers and attributed the effect to the concentration
ment No. 6, is evidently being violated by a number of of eugenol.94 From Germany, Schafer and Bossman
sealers. Van der Burgt from Holland and her associates reported on the efficacy of a new liquid antimicrobial,
reported that Grossmans cement, zinc oxideeugenol, camphorated chloroxylenol (ED 84), as a good tem-
Endomethasone, and N2 induced a moderate porary root canal dressing for a duration of 2 days.
orange-red stain to the crowns of upper premolar For a longer term dressing, they recommended calci-
teeth.85 She further found that Diaket and Tubli-Seal um hydroxide.95
caused a mild pink discoloration, whereas AH-26 Grossman stated in requirement No. 9 that sealers
gave a distinct color shift toward grey. On the other should not be soluble in tissue fluids. Smith96 and
hand, Rieblers paste caused a severe dark red stain. McComb and Smith97 found a wide variance in sealer
Diaket caused the least discoloration.86 As far as the solubility after 7 days in distilled water, ranging from
staining ability of other materials is concerned, Van der 4% for Kerrs Pulp Canal Sealer to much less than 1%
Burgt found that Cavit produced a light to moderate for Diaket (Figure 11-11). Peters found after 2 years
yellowish/green stain, that gutta-percha caused a mild that virtually all of the sealer was dissolved out of test
pinkish tooth discoloration, that AH-26 Silver-Free teeth filled by lateral or vertical compaction.98
and Duo Percha induced a distinct color shift towards Therefore most sealers are soluble to some extent.
Cements
Zinc OxideEugenol. An early ZOE cement,
developed by Rickert (Kerr Pulp Canal Sealer; Kerr
Dental; Orange, Calif.), has been the standard of the
profession for years. It admirably met the requirements
set down by Grossman except for severe staining. The
silver, added for radiopacity, causes discoloration of the
teeth, thus creating an undesirable public image for
endodontics. Removing all cement from the crowns of
teeth would prevent these unfortunate incidents.100
Pulp Canal Sealer (PCS) has more recently emerged
as the favorite sealer of the warm gutta-percha, vertical
condensation adherents. However, one of its disadvan-
tages was the rapid setting time in high heat/humidity
regions of the world. To solve this problem, Kerr
Figure 11-11 Solubility of root canal cements. Zinc reconfigured the formula into Pulp Canal Sealer EWT
oxideeugenol cements were most soluble, and polyketones and
(Extended Working Time) (Sybron Endo/Kerr;
polycarboxylates were least soluble. Reproduced with permission
from McComb D and Smith D.97 Orange, Calif.) that now has a 6 hour working time.
The regular-set cement is also still available. Recent
apical microleakage studies have shown the regular
The very important requirement No. 10, tissue tol- Pulp Canal Sealer (PCS) to be significantly better
erance, will be dealt with at length later in the chapter. than Roth 801 and AH26 at 24 weeks.101Additional
Suffice it to say at this time that the paraformalde- research, comparing sealing ability between regular
hyde-containing sealers appear to be the most toxic and Pulp Canal Sealer and the new EWT sealer, found no
irritating to tissue. A case in point is reported from significant difference between the two.102
Israel: necrosis of the soft tissue and sequestration of In 1958 Grossman recommended a nonstaining
crestal alveolar bone from the leakage of paraformalde- ZOE cement as a substitute for Rickerts formula.103
hyde paste from a gingival-level perforation.99 Now available as Roths Sealer, it has become the stan-
dard by which other cements are measured because it
Cements, Plastics, and Pastes reasonably meets most of Grossmans requirements for
The cements, which have wide American acceptance, cement. The formula is as follows68:
are primarily ZOE cements, the polyketones, and
epoxy. The pastes currently in worldwide vogue are Powder
chlorapercha and eucapercha, as well as the iodoform Zinc oxide, reagent 42 parts
pastes, which include both the rapidly absorbable and Staybelite resin 27 parts
the slowly absorbable types. Despite their disadvan- Bismuth subcarbonate 15 parts
tages, pastes are applicable in certain cases. The plastics Barium sulfate 15 parts
show promise, as do the calcium phosphate products. Sodium borate, anhydrous 1 part
At present the methods most frequently used in filling Liquid
root canals involve the use of solid-core points, that are Eugenol
inserted in conjunction with cementing materials.
Gutta-percha and silver per se are not considered ade- This cement is available commercially as Roths 801
quate filling material unless they are cemented in place (Roths Pharmacy, USA) or U/P Root Canal Sealer
in the canal. The sealers are to form a fluid-tight seal at (Sultan, USA).
All ZOE cements have an extended working time but The one common denominator of these medicated
set faster in the tooth than on the slab because of sealers is formaldehyde in one form or another. Since
increased body temperature and humidity. If the formalin is such a tissue-destructive chemical, it is no
eugenol used in the preceding nonstaining cement wonder that every cytotoxic test lists these sealers as the
becomes oxidized and brown, the cement sets too rap- number one irritant.
idly for ease of handling. If too much sodium borate It is the claim of their advocates that these sealers
has been added, the setting time is overextended. constantly release antimicrobial formalin. This appears
The main virtues of such a cement are its plasticity to be true, but it is this dissolution that breaks the seal
and slow setting time in the absence of moisture, togeth- and leads to their destructive behavior (see Tissue
er with good sealing potential because of the small volu- Tolerance of Root Canal Sealers, Cements, and Pastes).
metric change on setting. Zinc eugenate has the disad- Nogenol was developed to overcome the irritating
vantage, however, of being decomposed by water quality of eugenol.103 The product is an outgrowth of a
through a continuous loss of the eugenol. This makes noneugenol periodontal pack. The base is zinc oxide,
ZOE a weak, unstable material and precludes its use in with barium sulfate as the radiopacifier along with a
bulk, such as for retrofillings placed apically through a vegetable oil. Set is accelerated by hydrogenated rosin,
surgical approach.96 Other zinc oxidetype cements in methyl abietate, lauric acid, chlorothymol, and salicylic
use are Tubliseal (Sybron Endo/Kerr; Orange, Calif.), acid. Removing eugenol from Nogenol evidently does
Wachs Cement (Roths Pharmacy, Chicago Ill.), and exert the sought-after effect of reducing toxicity.
Nogenol (G-C America; Alsip, Ill. and Japan). It seems quite obvious that all these root canal
As Kerrs PCS fell into some disfavor because of cements differ widely in setting times, plasticity and
staining, the company developed a nonstaining sealer, physical properties. None of the materials show her-
TubliSeal. Marketed as a two-paste system, it is quick metic [sic] sealing in the literal sense.96
and easy to mix. It differs from Richerts cement in Calcium Hydroxide Sealers. In the second edition
that its zinc oxidebase paste also contains barium sul- of Endodontics (1976), Luebke and Ingle first forecast a
fate as a radiopacifier as well as mineral oil, cornstarch, new paradigm for endodontics: a broader use of calci-
and lecithin. The catalyst is made up of a polypale um hydroxide in medicating and sealing the root canal.
resin, eugenol, and thymol iodide. If the advantage of This is coming to pass, particularly with the introduc-
TubliSeal is its ease of preparation, its disadvantage has tion of the calcium hydroxide sealers.
been its rapid set, especially in the presence of mois- CRCS (Calciobiotic Root Canal Sealer, Coltene/
ture. The company has reformulated the sealer to Whaledent/Hygenic; Mahwah, N.J.) is essentially a
extend working time, and it is now available as ZOE/eucalyptol sealer to which calcium hydroxide has
Sealapex Regular or Sealapex EWT (Extended been added for its so-called osteogenic effect. CRCS takes
Working Time). 3 days to set fully in either dry or humid environments. It
Wachs Cement. Meanwhile, in the Chicago area, also shows very little water sorption.104 This means it is
Wachs cement became popular. A much more compli- quite stable, which improves its sealant qualities, but
cated formula, its powder base consists of zinc oxide, brings into question its ability to actually stimulate
with bismuth subnitrate and bismuth subiodide as cementum and/or bone formation. If the calcium
radiopacifiers, as well as magnesium oxide and calcium hydroxide is not released from the cement, it cannot exert
phosphate. The liquid consists of oil of clove along with an osteogenic effect, and thus its intended role is negated.
eucalyptol, Canada balsam, and beechwood creosote. SealApex (Sybron Endo/Kerr; Orange, Calif.) is also a
The advantage of Wachs is a smooth consistency calcium hydroxidecontaining sealer delivered as paste to
without a heavy body. The Canada balsam makes the paste in collapsible tubes. Its base is again zinc oxide, with
sealer tacky. A disadvantage is the odor of the liquid calcium hydroxide as well as butyl benzene, sulfonamide,
like that of an old-time dental office. and zinc stearate. The catalyst tube contains barium sul-
At one time, medicated variations of ZOE cements fate and titanium dioxide as radiopacifiers as well as a
were very popular and, to some extent, remain so today. proprietary resin, isobutyl salicylate, and aerocil R972. In
N2 and its American counterpart, RC2B, are the best 100% humidity, it takes up to 3 weeks to reach a final set.
examples, along with Spad and Endomethasone in In a dry atmosphere, it never sets. It is also the only seal-
Europe. There is no evidence that these products seal er that expands while setting.105 As with CRCS, the ques-
canals better than or as well as other sealers. However, tion remains: Is SealApex soluble in tissue fluids to release
there is evidence that they dissolve in fluid and thus the calcium hydroxide for its osteogenic effect? And if so,
break the seal. does this dissolution lead to an inadequate seal?
At Creighton University it was established that, in a Diaket (3M/Espe; Minneapolis, Minn.), an early one
limited surface area, such as in a minimal apical open- first reported in 1951, is a resin-reinforced chelate
ing, a negligible amount of dissolution occurred.106 formed between zinc oxide and a small amount of plas-
At Baylor University, however, Gutmann and Fava tic dissolved in the liquid B-diketone. A very tacky
found in vivo that extruded SealApex disappeared from material, it contracts slightly while setting, which is
the periapex in 4 months.107 This dissolution did not subsequently negated by uptake of water. In a recent
appear to delay healing. However, the authors suspect- dye-penetration study, the sealing ability of Diaket was
ed sealer dissolution may continue within the canal similar to Apexit but significantly better than Ketac-
system as well, thus eventually breaking the apical seal. Endo112 (3M/Espe; Minneapolis, Minn.).
If water sorption is an indicator of possible dissolu- AH-26 (Dentsply/Maillefer, Tulsa, Okla), an epoxy
tion, SealApex showed a weight gain of 1.6% over 21 days resin, on the other hand, is very different. It is a glue,
in water. In contrast, CRCS gained less than 0.4%.104 The and its base is biphenol A-epoxy. The catalyst is hexa-
fluid sorption characteristics of SealApex may be due to methylenetetramine. It also contains 60% bismuth
its porosity, which allows marked ingress of water. oxide for radiographic contrast. As AH-26 sets, traces
LIFE (Sybron Endo/Kerr; Orange, Calif.), a calci- of formaldehyde are temporarily released, which ini-
um hydroxide liner and pulp-capping material simi- tially makes it antibacterial. AH-26 is not sensitive to
lar in formulation to SealApex, has also been suggest- moisture and will even set under water. It will not set,
ed as a sealer.108 however, if hydrogen peroxide is present. It sets slowly,
From Liechtenstein comes an experimental calcium in 24 to 36 hours. The Swiss manufacturers of AH-26
hydroxide sealer called Apexit (Vivadent; Schaan, recommend that mixed AH-26 be warmed on a glass
Liechtenstein). Australians found that it sealed better slab over an alcohol flame, which renders it less vis-
than SealApex and ImbiSeal.109 cous. AH-26 is also sold worldwide as ThermaSeal
Japanese researchers have introduced a calcium (Dentsply/Tulsa; Tulsa, Okla.).
hydroxide sealer that also contains 40% iodoform. It is Recognizing the advantages of AH-26 (high
named Vitapex (NEO Dental, Japan), and its other radiopacity, low solubility, slight shrinkage, and tissue
component appears to be silicone oil.110 Iodoform, a compatibility), as well as some of its disadvantages
known bactericide, is released from the sealer to sup- (formaldehyde release, extended setting time [24
press any lingering bacteria in the canal or periapex. hours], and staining), the producers of AH26 set out to
One week following deposits in rats, Vitapex, containing develop an improved product they renamed AH PLUS
45Ca-labeled calcium hydroxide, was found throughout (Dentsply International). They retained the epoxy resin
the skeletal system. This attests to the dissolution and glue of AH26 but added new amines to maintain the
uptake of the iodoform material. No evidence is given natural color of the tooth. AH Plus comes in a
about the sealing or osteogenic capabilities of pastepaste system, has a working time of 4 hours and
Vitapex.110 NEO Dental has also produced another a setting time of 8 hours, half the film thickness and
ZOE-type sealer that contains not only iodoform but half the solubility of regular AH26, and may be
calcium hydroxide as well. It is called Dentalis and is removed from the canal if necessary. In a comparative
distributed in North America by DiaDent, Canada. It toxicity study, AH Plus was found to be less toxic than
sets rapidly (5 to 7 minutes) and is very tacky. regular AH-26.113 AH Plus is also sold worldwide as
Martin has also introduced a US Food and Drug ThermaSeal Plus (Dentsply/Tulsa; Tulsa, Okla.).
Administration (FDA)-approved ZOE sealer, MCS, Glass ionomer cements have also been developed for
Medicated Canal Sealer (Medidenta, Woodside, N.Y.), endodontics. One of these is presently marketed as
that contains iodoform, to go along with MGP gutta- Ketac-Endo (3M/Espe; Minneapolis, Minn.). Saito
percha points that also contain 10% iodoforml.55 Testing appears to have been an early proponent of endodontic
of MCS in vitro showed that it developed a bacterial glass ionomers. He suggested using Fuji Type I luting
zone of inhibition twice the size of regular ZOE sealer. cement to fill the entire canal.114 Pitt-Ford in England rec-
Researchers in Germany have also developed an ommended endodontic glass ionomers as early as 1976.115
experimental calcium hydroxide sealer that was report- However, he found the setting time too rapid. Stewart was
ed on favorably by Pitt-Ford and Rowe.111 combining Ketac-Bond and Ketac-Fil before these glass
ionomers were specifically formulated for endodontics.
Plastics and Resins He was pleased with the result in six cases.116
Other sealers that enjoy favor worldwide are based At Temple University, eight different formulations of
more on resin chemistry than on essential oil catalysts. Ketac cement were researched for ease of manipulation,
radiopacity, adaptation of the dentinsealer interface, tation depends on smear-layer removal, which is diffi-
and flow.117 Ray and Seltzer chose the sealer with the cult to achieve in the apical third of the canal.
best physical qualities: the best bond to dentin, the fewest At Loma Linda University, isopropyl cyanoacrylate
voids, the lowest surface tension, and the best flow. A was found to be more adequate in sealing canals than
method of triturating and injecting the cement into the were three other commercial sealers.128 However, fur-
canal was also developed. Ketac-Endo was the outcome. ther research was discontinued because of a lack of
In a follow-up study, the Temple group evaluated the acceptance by the FDA (M. Torabinejad, personal
efficacy of Ketac-Endo as a sealer in obturating 254 communication, August 1997).
teeth in vivo. At the end of 6 months, they reported a A polyamide varnish, Barrier (Interdent, Inc; Culver
success and failure rate comparable to that of other City, Calif.), has also been tried as a sealer but was
studies using other sealers.118 found to be not as effective as ZOE.129
Their greatest concern was the problem of removal in At the University of Minnesota, the efficacy of four
the event of re-treatment since there is no known solvent different dentin bonding agents used as root canal seal-
for glass ionomers. A Toronto/Israel group reported, ers was tested.No leakage was measurable in 75% of the
however, that Ketac-Endo sealer can be effectively canals sealed with Scotchbond (3-M Corporation; South
removed by hand instruments and chloroform solvent El Monte, Calif.), in 70% of canals sealed with Restodent
followed by one minute with an ultrasonic No. 25 file.119 (Lee Pharmaceuticals; St. Paul, Minn.), in 60% of canals
More recently, leakage studies compared Ketac-Endo sealed with DentinAdhesit (Ivoclar; Schaan,
with AH26120,121 and Roths 801E and AH26.122 US Leichtenstein), and in only 30% of canals sealed with
Navy researchers found Ketac-Endo allowed greater dye GLUMA130 (Bayer Dental; Laver Kusan, Germany). The
penetration than Roths 801E and AH26.122 On the same researchers reported the dramatic improvement
other hand, the Amsterdam group found AH26 leaked in the quality of sealing root canals using dentin bond-
more than Ketac-Endo. They related the difference to ing agents.131
film thickness: 39 microns for AH26 and 22 microns for It seems quite probable that dentin bonding agents
Ketac-Endo.120 In addition, the new AH product, AH will play a major role in sealant endodontics. Their
Plus, has half the film thickness of regular AH26. ability to halt microleakage is a superb requisite for
Conversely, a Turkish group found no statistical differ- future investigation. The Minnesota study130 returned
ences in leakage between Ketac-Endo and AH26.121 to single-cone gutta-percha filling with the adhesives,
As far as toxicity is concerned, two Greek studies the cone inserted undoubtedly to spread the adhesive
found Ketac-Endo to be a very biocompatible materi- laterally and to occupy space to reduce shrinkage. One
al. The first study compared Ketac-Endo to Endion, might even visualize a rebirth of the silver point com-
which they found to be highly toxic,123 and the sec- bined with one of the adhesives such as Amalgambond
ond study found only mild inflammation with Ketac- (Parkell Co., Farmingdale, N.Y.), which adheres to
Endo, whereas TubliSeal (Sybron Endo/Kerr; Orange, dentin as well as to metals.
Calif.) caused necrosis and inflammation as long as 4 From Zagreb, Croatia, a group used two different
months later.124 A study from Mexico, however, found compaction methods, vertical and lateral, to condense
that Ketac Silver, the precursor to Ketac-Endo, composite resin with a bonding agent as a total filling
induces irreversible pulpal damage.125 material. They first developed an apical plug with bond-
ing agent Clearfil (Morita Co.; Irvine, Calif. and Japan)
Experimental Sealers and then photopolymerized layer on layer of composite
In the never-ending search for the perfect root canal resin with an argon laser as they compacted the compos-
sealers, new fields have been invaded, including resin ite with pluggers. They found fewer voids in their final
chemistry, which is proving so successful in restorative filling than with lateral condensation132 (Figure 11-12).
dentistry, and calcium phosphate cements, which are a From Siena, Italy, another group used dentin bonding
return to nature. agents, along with AH26 sealer and gutta-percha lateral-
Early on, at Tufts University, a group experimented ly condensed, to obturate canals for leakage tests. They
with a Bis GMA unfilled resin as a sealer.126 The new found less leakage in those cases in which the bonding
material was found to be biocompatible but impossible agents were used along with AH26 versus AH26 alone.133
to remove.
Low-viscosity resins such as pit and fissure sealants Problems
have also been tried as sealers but would not seem Some obvious obstacles must be overcome, however,
suitable as root canal filling materials.127 Close adap- before these bonding agents become commercial
A B
Figure 11-12 A, Apical bonding plug of Clearfil. Margin between bonding plug and composite filling can be seen clearly. B, Bundles of the
resin tags remaining at the composite replica after the dentin was dissolved in vitro. Reproduced with permission from Anic I et al.132
endodontic sealants. First is preparation of the dentin greater detail at the end of this chapter (see A New
to remove all of the smear layer. As Rawlinson pointed Endodontic Paradigm).
out, it is very difficult to remove all of the smear from
the apical third canal, even if sodium hypochlorite and Sealer Efficacy
citric acid are used with ultrasonic dbridement.127 Hovland and Dumsha probably summarized it best:
A second obstacle is radiopacity. Radiopaquing metal Although all root canal sealers leak to some extent
salts must be added to the adhesive, and this is sure to there is probably a critical level of leakage that is unac-
upset the delicate chemical balance that leads to poly- ceptable for healing, and therefore results in endodon-
merization.134 All of the bonding agents are very tech- tic failure. This leakage may occur at the interface of the
nique sensitive, and many do not polymerize in the dentine and sealer, at the interface of the solid core and
presence of moisture or hydrogen peroxide.135 The sealer, through the sealer itself, or by dissolution of the
third problem is placement: Which delivery system will sealer.139 And one might add, microleakage from the
best ensure a total, porosity-free placement?136 A final crown down alongside even a well-compacted root fill-
obstacle is removal in the event of failure. These resins ing. The authors went on to find that Sealapex was no
polymerize very hard, all the more reason to place a different after 30 days than TubliSeal or Grossmans
gutta-percha core allowing future entry down the canal. Sealer when it comes to leakage.139
No question, there is a variance in the impermeabil-
Calcium Phosphate Obturation ity of the many sealers on the market. The literature is
The possibility that one could mix two dry powders replete with test after test, most done without prejudice
with water, inject the mixture into a root canal, and but some done to promote a product. Microleakage
have it set up as hard as enamel within 5 minutes is research can be rigged to prove a point. Should I use
exciting, to say the least. And yet just such a possibility radioisotopes, or should I use India ink with its large
may be emerging. particle size? Should I use methylene blue or should I
Developed and patented at the American Dental use bacteria larger than the tubuli? Should I allow the
Association (ADA) Paffenbarger Research Center at the sealer to set on the bench top or in 100% humidity?
National Institute of Standards and Technology by Drs. Should I test immediately, at 24 hours, 1 week, 1
W. E. Brown and L. C. Chow and their associates, calci- month? Should the tests be done under normal atmos-
um phosphate cements might well be the future ideal pheric pressure or under vacuum? Should I centrifuge
root canal sealer, long sought but never achieved.137,138 the test pieces? Should I remove the smear layer? All of
In mixing two variations of calcium phosphate with these factors have been shown to affect sealability
water, Brown and Chow demonstrated that hydroxyap- results materially, to favor one product over another.
atite would form.The pros and cons of calcium phos- In choosing a sealer, factors other than adhesion
phate (hydroxyapatite) obturation is discussed in must be considered: setting time, ease of manipulation,
antimicrobial effect, particle size, radiopacity, proclivi- More recent studies relating to zinc oxide-base sealers
ty to staining, dissolvability, chemical contaminants (and those previously referenced) have found essentially
(hydrogen peroxide, sodium hypochlorite), cytotoxici- the same results for ZOE and calcium hydroxide sealer
ty, cementogenesis, and osteogenesis. solubility,96,98,105,106,110 leakage,104,108,109,127,139,141,153159
Therefore, rather than quoting from the endless list and bacterial inhibition.88,91,151,160,161
of reports, each one suppressing or refuting another, a Despite their deficiencies, ZOE cements and their
resum will be presented and a long list of references variations continue to be the most popular root canal
provided for perusal by the interested student. sealers worldwide. But they are just that, sealers, and
Resum of Adhesion. All presently available seal- any attempt to depend on them wholly or in great part
ers leak; they are not impermeable. That is the first materially reduces long-term success. That is the prin-
caveat. The second is that some leak more than others, cipal reason why silver points failedtoo little solid
mostly through dissolution. The greater the sealer/peri- core and too much cement in an ovoid canal (see
radicular tissue interface, that is, apical perforations or Figure 11-9, A).
blunderbuss open apices, the faster dissolution takes If the apical orifice can be blocked principally by
place. It goes without saying that readily dissolving solid-core material, success is immeasurably improved
sealers are not indicated in these cases. over the long term, if not for a lifetime.162 On the other
Zinc Oxide, Calcium Hydroxide-Type Sealers. In hand, in every study in which obturation without seal-
a 2-year solubility study, Peters found that ZOE sealer ers is attempted, the leakage results are enormously
was completely dissolved away.98 This fact alone should greater. Sealers are necessary! Researchers agree, how-
cause one to question the advisability of totally filling ever, that thorough cleaning and shaping of the canal
the canal with ZOE cement. space are the key to perfect obturation.
One might think that first lining the canal with var- Plastic and Resin-Type Sealers. It seems reason-
nishes such as Barrier129 or Copalite140 might improve able to assume that plastics, resins, and glues should be
the seal, but neither does. more adhesive to dentin and less resorbable than the
On the basis of leakage studies alone one would be mineral oxide cements. But they have not proved to be
hard pressed to favor one of the ZOE or zinc oxide-cal- dramatically so. In one study, AH-26 was found com-
cium hydroxide sealers over the others. Kerrs Pulp parable to ZOE sealer but better than six others.141
Canal Sealer (Rickerts), Nonstaining Root Canal Sealer In another study, AH-26 and Diaket were found
(Grossmans), Wachs Sealer, TubliSeal, Nogenol, CRCS, satisfactory as sealers along with all the ZOE prod-
SealApex, Vitapex, Apexit, or even Dycal or Life, all ucts.142 Another study found Diaket less effective than
appear to be a wash when numerous studies are TubliSeal but better than N2.143
examined.104,112,120122,132,133,141147 A study compar- In a recent Australian study, however, AH-26 was
ing the newer Kerr Pulp Canal Sealer EWT (Extended found to have better sealing capabilities than were three
Working Time) versus the original Pulp Canal Sealer other cements: Apexit, Sealapex, and TubliSeal.108,109 In
found no significant difference in microleakage.102 New Zealand, however, Sealapex outperformed AH-26
Moreover, recent studies comparing Pulp Canal Sealer up to the twelfth week, but there was no significant dif-
(PCS) with Roth 801 and AH26 found PCS a signifi- ference after that time.158
cantly better sealant.101 As far as the new glass ionomer cement, Ketac-Endo,
The reports are not as favorable, however, for the is concerned, Ray and Seltzer found it superior to
paraformaldehyde-containing sealers N2, RC2B, Spad, Grossmans Sealer,117 but others found it difficult to
and Endomethasone. Sargenti has asserted that oblitera- remove in re-treatment.118 More recently, Dutch
tion, along with disinfection, is important for success.148 researchers found Ketac superior in sealing to AH26.120
On the other hand, he has stated that it is not mandato- On the other hand, US Navy researchers found Roths
ry to have a compact root canal filling.149 He also claims 801E and AH26 superior to Ketac Endo.122 Moreover,
that N2 is not resorbed from the canal but is slowly one Turkish group found Apexit and Diaket superior to
absorbed from the periradicular tissues, an action he calls Ketac,112 but a second Turkish group found no differ-
semi-resorbable.149 At another time and place, he mod- ence.121 It would appear the jury is still out on the
ifies the statement by saying that N2 is practically non- sealing ability of Ketac Endo.
resorbable from the canal.148 Yates and Hembree found The early leakage reports on the adhesives used
N2 to be the least effective sealer when compared with experimentally as root canal sealers are most encourag-
TubliSeal or Diaket after 1 year.143 Block and Langeland ing. A 1987 report, when adhesives were in their infan-
reported 50 failed cases treated with N2 or RC2B.150 cy, placed Scotchbond first, with no leakage measura-
ble in 75% of the canals and GLUMA last, with 30% At present, four approaches are being used to evalu-
showing no leakage.130,131 Adhesives today are in their ate scientifically (as opposed to empirically) the toxic
third and fourth generations, far superior to the initial effects of endodontic materials: (1) cytotoxic evalua-
resins. Also, there are adhesives such as C & B tion, (2) subcutaneous implants, (3) intraosseous
Metabond (Parkell Co., USA) or All Bond (Bisco implants, and (4) in vivo periradicular reactions. The
Products, USA) that actually polymerize best in a moist studies done on the toxicity of the materials in question
environment. Canals obturated for leakage studies with are categorized into these four evaluative methods.
laterally condensed gutta-percha sealed with a combi- Cytotoxic Evaluation. Cytotoxic studies are done
nation of dentin bonding agents plus AH26 versus by measuring leukocyte migration in a Boyden cham-
AH26 alone were to be found to be superior.133 ber; by measuring the effect that suspect materials or
A thoroughly modern approach of sealing the apical their extracts have on fibroblasts or HeLa cells in cul-
foramen with a resin bond called Clearfil (Morita Co.; ture; or by using radioactively labeled tissue culture
Irvine, Calif.), followed by obturation with a composite cells, or tissue cultureagar overlay, or a fibroblast
resin condensed laterally as it was being photopoly- monolayer on a millipore filter disk. The results are
merized in the canal with an argon laser, layer by layer, quite similar.
shows promise for the future (see Figure 11-12).132 The numerous cytotoxic evaluations may be summa-
With any use of dentin adhesives and/or compos- rized by stating that a disappointing number of todays
ite resin, it is imperative that the smear layer be sealers are toxic to the very cells they have been com-
removed so that the hybrid layer may form against pounded to protect. Some of them are toxic when first
the dentin and the adhesive is able to flow into the mixed, while they are setting over hours, days, or weeks,
dentinal tubuli (see Figure 11-12, B). Once again, the and some continue to ooze noxious elements for years.
difficulty of removing the smear layer in the apical This is, of course, caused by dissolution of the cement,
region must be emphasized.127 thus releasing the irritants. All of the zinc oxide-type
Experimental Calcium Phosphate Sealers (CPC). sealers, for example, gradually dissolve in fluid, releasing
Already, the early reports on Japanese apatite sealers eugenol, which Grossman, in 1981, pointed out is a
find them comparable to Sealapex but better sealants phenolic compound and is irritating (L.I. Grossman,
than two other ZOE cements.163 personal communication, August 1981). More recently,
Studies emanating from the A.D.A. Paffenbarger this has been confirmed by the group in Verona, Italy.166
Center find calcium phosphate cements very praise- Chisolm introduced zinc oxide and oil of clove
worthy for their sealing properties as well as for their (unrefined eugenol) cement to dentistry in 1873.167
tissue compatibility. In one study, they proved better One would think that after 125 years something less
sealants than a ZOE/gutta-percha filling.164 In another toxic would be the favorite root canal sealer.167 Eugenol
study, researchers found that the apatite injectable is not only cytotoxic but neurotoxic as well.168
material demonstrated a uniform and tight adaptation Zinc oxide and eugenol, even when calcium hydrox-
to the dentinal surfaces of the chambers and root canal ide is added to the mixture, has been found universally
walls. CPC also infiltrated the dentinal tubules.165 to be a leading cytotoxic agent.168181 Removing eugenol
Since these sealers set as hydroxyapatite, one must be (or any of the essential oils) from the mixture greatly
aware that they are very difficult, but not impossible, to reduces the toxicity. Witness the spectacular differences
remove from the canal. in cytotoxicity when unsaturated fatty acids are substi-
tuted for eugenol and/or eucalyptol in sealers such as
Tissue Tolerance of Root Canal Sealers, Nogenol or experimental Japanese sealers.105,182,183
Cements, and Pastes Eugenol alone is not the only culprit in ZOE irrita-
Without question, all of the materials used at this junc- tion. Zinc oxide itself must also be indicted. Early on,
ture to seal root canalsgutta-percha, silver, the seal- Das found zinc oxide to be quite toxic.57 More recent-
ers, cements, pastes, and plasticsirritate periradicular ly, Meryon reported that the cytotoxicity of ZOE
tissue if allowed to escape from the canal. And, if placed cement may be based more on the possible toxic effect
against a pulp stump, as in partial pulpectomy, they of zinc ions.184 Maseki et al. also indicated that zinc
irritate the pulp tissue as well. The argument seems to might be a major offender when they found that dilu-
be not whether the tissue is irritated when this happens tions of eugenol released from set cement allowed via-
but rather to what degree and for how long it is irritat- bility of 75% of their test cells.185
ed, as well as which materials are tolerable or which are Toxicity from zinc ions may well extend beyond that
intolerable irritants. found in sealers. In testing the toxicity of gutta-percha
points, Pascon and Spngberg concluded that all brands lowed 92 cases for up to 612 years after the canals had
of points were highly cytotoxic and further that been overfilled with standard ZOE (Grossmans-type
although pure raw gutta-percha was nontoxic, zinc sealer). In no recall 50 months or longer did material
oxideshowed high toxicity. The toxicity of gutta-per- remain in the periradicular tissues was their conclu-
cha points was attributed to leakage of zinc ions into the sion. In 12 cases, careful evaluation of the radi-
fluids.186 Adding calcium hydroxide to ZOE-type ographs of these cases convinced the authors that seal-
cements mollifies their toxicity somewhat.178,179 er had also been absorbed from within the canal.192
If one were forced to classify popular ZOE-type seal- Cytotoxic studies on the plastics and resins reveal
ers from worst to best as far as cytotoxicity studies are much the same results as with the zinc oxide-type
concerned, one would have to rank the pure ZOE seal- cements. For example, some have found AH-26, the
ers as worst: Grossmans and Rickerts, followed by epoxy resin, the most toxic of the resins tested,183 and
Wachs and TubliSeal, Sealapex, CRCS, and finally some found it the least toxic. In the latter study, Diaket
Nogenol,183 although there is not universal agreement (and TubliSeal) showed moderate cytotoxic effect.193 In
on this total ranking. At Loma Linda University, for contrast, both studies found that formaldehyde-con-
example, TubliSeal was found the least toxic followed taining sealers were highly toxic.183,193
by Wachs and Grossmans,175 whereas at Connecticut, Early on, a US Navy study found AH-26 the least
Wachs ranked ahead of TubliSeal.174 Later at the toxic, as did a study at Tennessee.169,172 Again, Diaket
University of Connecticut, however, researchers report- was in between. Swedish dentists reported a mild
ing in vitro studies found TubliSeal to be virtually response using AH-26.194 In Buenos Aires, AH-26 was
non-toxic at all experimental levels.177 In marked con- found to have a moderate effect and Diaket a markedly
trast, a Greek group reported in vivo studies showing toxic effect, both at the end of 1 hour.195 AH-26,
TubliSeal exhibited severe inflammation and necrosis remember, releases formaldehyde as it sets. Both of
as long as 4 months later.124 The same group also found these resin sealers were much less toxic, however, than
Apexit (a calcium hydroxide additive sealer) and Kerrs the ZOE control. Statistically significant were the very
classic Pulp Canal Sealer (ZOE) remained as irritants mild effects of glass ionomer endodontic sealer.195
over a 4-month period.187 Researchers in India also Newer formulationsAH Plus and Ketac Endo
found TubliSeal severely toxic at 48 hours and 7 days have had cytotoxic and genotoxic studies done.113,123
but not so at 3 months.188 AH Plus was compared with its original product, AH
An extensive study in Venezuela found that CRCS 26, and in an in vitro test caused only slight or no cel-
(ZOE-calcium hydroxide additive) was the least cytotox- lular injuries and did not cause any genotoxicity or
ic against human gingival fibroblasts, followed by mutagenicity.113 In a study done in Greece, Ketac Endo
Endomet and AH26. They also reported that MTA proved to be a very biocompatible material, whereas
(Dentsply/Tulsa; Tulsa, Okla.) root-end filling material Endion was highly cytotoxic.123
was not cytotoxic.189 Another study of calcium hydrox- Subcutaneous Implants. Subcutaneous implants
ide-containing sealers found that, with Sealapex, no of root canal sealers, to test their toxic effects, are done
inflammatory infiltrate occurred, whereas with CRCS, a either by needle injection under the skin of animals, or
moderate inflammatory infiltrate occurred. by incision and actual insertion of the product, either
Inflammation of the severe type accompanied alone or in Teflon tubes or cups. Freshly mixed mate-
Apexit.190 rial may be implanted, allowing it to set in situ, or
Paraformaldehyde-containing sealers are some- completely set material may be inserted to judge
thing else. Not only do they generally contain zinc long-term effects.
oxide and eugenol, but they also boast 4.78 to 6.5% The results are what one would expect from the cyto-
highly toxic paraformaldehyde. Virtually every cytotox- toxicity studies. Eugenol, as all of the essential oils, is a
ic study on N2, RC2B, Traitment SPAD, tissue irritant,196198 particularly during initial set.104
Endomethasone, Triolon, Oxpara, Rieblers paste, and The long-term results are also not promising.199,200
so forth finds these materials to be the most toxic of all As Tagger and Tagger observed after 2 months, the
the sealers on the market, bar none.171,172,191 This is more severe subcutaneous tissue reaction to the zinc
discussed further later in the chapter. oxide-eugenol sealer was probably due to the instabili-
Once again one must bear in mind that the resorba- ty of the material, which slowly disintegrated in contact
bility, the dissolvability of all of the zinc oxide sealers, with tissue moisture.201,202
allows them to continue to release their toxic elements At Northwestern University Nogenol proved to be
and to break their seal. Augsburger and Peters fol- better tolerated initially than TubliSeal or Richerts
sealer, but at 6 months the effects of TubliSeal were In Vivo Tissue Tolerance Evaluations. There is no
worse and the effects of Richerts (Kerrs RCS) and question that the ideal method of testing a drug, a sub-
Nogenol were the same.104 Both contain zinc oxide. stance, or a technique is in vivo in a human subject.
Initial inflammation surrounding implants of Unfortunately, human experimentation is often dan-
SealApex and CRCS, the calcium hydroxide sealers, gerous, costly, and unethical, and therefore, for the
appears to be resolved at 90 days.203 Yesilsoy found most part, animals are substituted. It can also be said
SealApex caused a less severe inflammation reaction that the closer one rises up the phylum tree to Homo
than did CRCS. Both Grossmans ZOE sealer and sapiens, the more valid the experiment: Monkeys are
CRCS did not have overall favorable histologic reac- better than dogs, and pigs, believe it or not, are better
tions.203 Japanese researchers, announcing a new cal- than cats.
cium hydroxide sealer, Vitapex, which also contains In any event, many of the earlier studies were done
iodoform and silicone oil, stated that granulation tissue on rats. This was tiny meticulous root canal therapy
formed around the implanted material and a nidus of compared with the treatment of human beings.
calcification then developed within this tissue.204 Erausquin and Muruzabal, working in Buenos Aires,
AH-26 elicited no response at 35 days in one performed the seminal in vivo research on tissue toler-
study205 and was well tolerated at 60 days in anoth- ance to sealers with hundreds of tests on techniques
er.126 Without question, N2 and other paraformalde- and materials.215 They concluded that all of the com-
hyde/ZOE cements are consistently the most toxic.205,206 mercial root canal sealers were toxic, causing extensive
Tissue-implantation ranking of endodontic sealers to moderate tissue damage as soon as they escape
would again have to list Nogenol, then AH-26, SealApex, through the foramen (Figure 11-13). In all honesty,
and TubliSeal. CRCS, along with the ZOE sealers, would however, the authors did believe that periradicular
rank higher in toxicity, and the formaldehyde cements necrosis may be due in part to an infarct caused by
rank as unacceptable. A recent comparative study found pressure obstruction of the regions vessels.216 Necrosis
the formalin-containing cements caused faster and more of the periodontal ligament provoked necrosis in the
prolonged nerve inhibition and paresthesia.207 adjacent cementum and alveolar bone as well (Figure
Osseous Implant. Surprisingly, sealers implanted 11-14). In the rat, the periodontal ligament regenerat-
directly into bone evoke less inflammatory response than ed within 7 days if toxic irritation did not continue.
these same cements evoke in soft tissue. From Marseille In comparing the various sealers, Erausquin and
comes a report of two ZOE sealers implanted into rab- Muruzabal found that straight ZOE cement was high-
bits mandibles. At 4 weeks, both sealer implants showed ly irritating to the periradicular tissues and caused
slight to moderate reactionsno bone formation or necrosis of the bone and cementum.217 Inflammation
bone resorption. At 12 weeks, there were slight to very persisted for 2 weeks or more. Finally, the ZOE became
slight reactionsbone formation in direct contact with encapsulated. Much the same inflammatory reaction
the sealersand bone ingrowth into the implant tubes. was observed at the US National Bureau of Standards
Part of the implanted sealer was absorbed, and when monkey teeth were overfilled with ZOE
macrophages were loaded with the sealer.208 cement218 (Figure 11-15).
A US Army group found essentially the same as the In a further study, Erausquin and Muruzabel studied
French group.209 When Deemer and Tsaknis overfilled other ZOE-based cements. All of the cements, if the
the tubes, the overfillings did not significantly com- canal was overfilled, showed a tendency to be
promise the healing of the rat intraosseous tissue. resorbed by phagocytes. Grossmans Sealer and N2
However, they noted the irritating properties of unset both provoked severe inflammatory reactions, and
Grossmans sealer.210 Rickerts sealer caused moderate infiltration. The most
In Argentina, Zmener and Dominguez tested glass severe destruction of the alveolar bone, however, was
ionomer cements in dog tibias and stated that at 90 caused by poor dbridement and poor filling of the
days the inflammatory picture had resolved with pro- canals. The least reaction was found when the canal
gressive new bone formation.211 was not overfilled.215
Again, the paraformaldehyde-containing cements The tissue reactions to overinstrumentation and over-
came off second best.212214 filling noted by Erausquin and Muruzabal were con-
There is not enough evidence to rank cements firmed by Seltzer and colleagues.219 In all cases, they found
implanted into bone. However, one must be impressed immediate periradicular inflammation in response to
with the mild-to-stimulating reactions that are report- overinstrumentation. When the root canals were filled
ed in bone. short of the foramen, the reactions tended to subside
A B
Figure 11-13 Periradicular tissue reaction to overfilling of rats teeth. A, Filling with Procosol Nonstaining Sealer (zinc oxideeugenol) 1
day postoperatively. Polymorphonuclear leukocytes have invaded even crack in cement. B, Filling with zinc oxideeugenol cement 4 days
postoperatively. Early polymorphonuclear leukocyte infiltration in reaction to material is apparent. Reproduced with permission from
Erausquin J, Muruzabal M. Arch Oral Biol 1966;11:373.
A B
Figure 11-15 Monkey study, periradicular area, 2 months after ZOE Grossman Sealer overfill (Gs). A, Acute inflammation with giant cells
(Gc) and necrotic bone sequestration (SEQ). B, Marked acute inflammation. Polymorphonuclear leukocytes predominate. Reproduced with
permission from Hong YC et al.218
within 3 months and complete repair eventually took More recently, Norwegian researchers tested AH26
place. In contrast, the teeth with overfilled root canals against Endomethasone, Kloropercha, and ZOE. At 6
exhibited persistent chronic inflammatory responses. months they concluded that the periradicular reaction
There was also a greater tendency toward epithelial prolif- to the endodontic procedures and to the materials was
eration and cyst formation in the overfilled group. limited.222 On the other hand, the University of
Another South American group reported on dog peri- Connecticut group found long-term (2 or 3 years) dif-
radicular specimens overfilled with SealApex, CRCS, and ferences, ranking AH26 as a mild irritant, ZOE as mod-
ZOE. All responded with chronic inflammation.220 erate, and Kloropercha as severe.223
The least irritating of the cements tested by Erausquin One must remember that gutta-percha points them-
and Muruzabal were Diaket and AH-26. Following over- selves can be a periradicular tissue irritant,186,224,225 as
filling with these sealers, the inflammation was general- well as an allergen.226 Moreover, solvents such as chlo-
ly very mild. Diaket, which showed a marked tendency roform, eucalyptol, and xylol can also act as irritants.227
to be projected beyond the apex, became readily encap- One must conclude that periradicular tissue reac-
sulated (Figure 11-16). AH-26, on the other hand, was tion to all of the cements will at first be inflammatory,
resorbed instead (Figure 11-17). The researchers but as the cements reach their final set, cellular repair
observed, when a foreign body is not too irritating, it takes place unless the cement continues to break down,
becomes either resorbed or encapsulated by the body releasing one or more of its toxic components.
(see Figure 11-17). Both of these processes occurred in In retrospect, one must not overlook the casual obser-
teeth filled with Diaket and AH-26.221 vation made by the group at Tufts University: There
Figure 11-16 A, Moderate overfilling with Diaket 15 days postoperatively. Debris from instrumentation is to right of apex and black fill-
ing. B, High-power (22 original magnification) view of Diaket and periapex. Loose connective tissue, abundance of fibroblasts, and some
macrophages and giant cells are apparent. Dentinal debris (right border) is also being attacked by macrophages. Reproduced with permis-
sion from Erausquin J and Muruzabal M.221
were several small well-encapsulated areas of mild seem that the dental profession has not yet decided
inflammation that seemed to be associated with apical upon a universal root canal filling material.228
ramifications that were not cleaned and that contained The N2/Sargenti Controversy. The term N2, as
necrotic debris.224 Although arborization of the pulp at used here, is a code word for formaldehyde-containing
the periapex is more apt to happen in dogs and monkeys endodontic cements. Actually, formaldehyde is a gas,
than in humans, one cannot blink away the fact that a whereas the forms used in dentistry are variations of
final filling is no better than its preparation, and if formalin, the aqueous solution, or paraformaldehyde, a
necrotic and infected dentin and debris are left in place, white crystalline polymer.
the case stands a greater chance of eventual failure. N2 itself contains 6.5% paraformaldehyde, as does its
One can summarize the discussion on root canal US counterpart, RC2B. Other paraformaldehyde/for-
sealers by repeating a statement made more than 100 malin-containing cements, popular in Europe, such as
years ago by Dr. A. E. Webster of Toronto: It would Endomethasone, Rieblers Paste, or the SPAD products,
may contain more or less than 6.5% formaldehyde. All
of them are toxic.
Legal Status in the United States. The controversy
swirling around N2 and RC2B deserves special discus-
sion. The use of these cements, recommended primari-
ly by members of the American Endodontic Society (a
group of general dentists), has become a cause clbre,
pitting endodontist against generalist, academician
against practitioner. Along with these cements comes a
method of practicethe so-called Sargenti Method.
The method and Sargenti have been imported from
Switzerland, but the N2 cement was barred at the bor-
ders by the FDA in about 1980. To evade the importa-
tion ban, disciples of Sargenti developed their own
(and very similar) cement powder, RC2B. This was
also banned under an FDA order that stated that the
Agency will take immediate regulatory action to stop
Figure 11-17 Fragments of AH-26 scattered throughout periradic-
ular tissue 30 days postoperatively, indicating resorption of sealer.
the commercial manufacture and distribution of N2
Giant cells surrounded large fragment of AH-26. Reproduced with type drugs (R. J. Crout, personal communication,
permission from Erausquin J and Muruzabal M.221 June 19, 1980).
The FDA pointed out, however, that they do not reg- denouncing these products, has been published in the
ulate the practice of dentistry and that an endodontist last 25 years from all over the world.248256 Pitt-Ford
or a general dentist may use the N2 product them- found, for example, that N2 and Endomethasone
selves or arrange to have a supply obtained by prescrip- caused a universal ankylosis and root resorption of
tion for that individual patient. The dentist, however, dogs teeth filled, but not overfilled, with these toxic
should recognize that he is responsible for the conse- products.250
quences of the use of N2 within his practice (R. J. The two most definitive in vivo studies on the effects of
Crout, personal communication, June 19, 1980). paraformaldehyde were done at Indiana University.257,258
The basis for these actions and this warning is the In a 1-month study using monkeys, researchers found
statement,The Food and Drug Administration has long apical periodontitis around 7 of 9 apices and a granulo-
held, and still does, that N2 has not been demonstrated ma with considerable loss of bone around another when
to be safe and effective for use in root canal therapy (R. RC2B was applied to 10 inflamed pulps, as recommend-
J. Crout, personal communication, June 19, 1980). ed by Sargenti. The treated pulps were in no better
As late as 1992, the FDA was still warning dentists shape than the untreated inflamed controls.257
that the N2 material is considered to be an unap- At 6 months and 1 year, severe periradicular inflam-
proved new drugand may not legally be imported or mation with liquefaction necrosis developed after
distributed in interstate commerce,229 and in 1993 RC2B was applied to coronal pulps with pulpitis. None
an advisory panel to the FDA rejected new drug appli- of the control teeth had periradicular inflammation.258
cation No. 19-182 submitted by N2 Products When RC2B was used to fill well-prepared root canals,
Corporation of Levittown, Pennsylvania.230 previously allowed to become necrotic, the results were
This action follows on the heels of jury awards of even more overwhelming: osteomyelitis at 6 months
$250,000 in one case and $280,000 in another to and abscess formation, even cyst formation, within
patients injured by overextension of N2 into the peri- massive periradicular lesions at 1 year (Figure 11-18).
radicular tissues of two female patients.229,231 The cases treated with RC2B were no better, or were
Paralegally, the Council on Dental Therapeutics of worse, than the necrotic canal cases left open to salivary
the American Dental Association reissued a resolution bacteria (Figure 11-19). Around a fragment of RC2B
against paraformaldelyde sealers that concluded that found in the tissue, advanced inflammation, necrosis,
the FDA has not approved any products with this for- and even osteomyelitis were present (Figure 11-20). At
mulation, [so] the Council cannot recommend the use the National Bureau of Standards, much the same
of these products at this time.232 This report but- destruction was found (Figure 11-21).218
tressed two previous negative pronouncements by The most important constituent in any of these
Council in 1977 and 1987.233,234 cements (N2, RC2B, Endomethasone, SPAD) is the
At the state level, the Florida Board of Dentistry has paraformaldehyde, according to their proponents. As a
banned Sargenti cement, charging that use of the filling matter of fact, Sargenti allows for the removal of any
material falls short of the minimum standard of (den- ingredient from the powder except paraformalde-
tal) care in Florida.235 This action was precipitated by a hyde.148 Unfortunately, it is this toxic product, unique
number of lawsuits, including an out-of-court settle- to these cements, that causes the destruction. It is its
ment for $1,000,000 to a woman horribly disfigured release, as the sealers are resorbed, that allows for their
after paraformaldehyde paste was misused (R. Uchin, destructive behavior. Neiburger reported a case show-
personal communication, September 22, 1992). ing radiographic disappearance of RC2B from the peri-
The American Association of Endodontists has also apex within 5 weeks.259 The Indiana group noted
issued a position statement condemning the use of resorption of RC2B within 1 month.257
paraformaldehyde sealers.236 Nerve Damage from Paraformaldehyde. It has
Paraformaldehyde Toxicity. As initially com- long been recommended by its proponents that N2 be
pounded, N2 was a ZOE cement containing 6.5% placed in the canal with a fast-spinning Lentulo spiral.
paraformaldehyde as well as some lead and mercury This is a perfectly reasonable approach, but one has to
salts. Concern over lead and mercury transport via the know when enough is enough. Sargenti warns that,
bloodstream to vital organs237247 forced the American without great care, overfilling is likely with this tech-
producers of the N2 lookalike, RC2B, to drop the heavy nique. He does not say, however, how very damaging
metals. However, in no way would they reduce the toxic such overextension will be.148 Periradicular destruction
paraformaldehyde from the formula. A myriad of dam- was shown in the Indiana studies.257,258 Also, the ADA
aging research papersin vitro, in vivo, clinical Council on Dental Therapeutics and Devices has
Figure 11-18 N2/RC2B formalin cement study. A, Control specimen, pulp necrosis 3 months standing. Apical granuloma with epithelial
proliferation. B, Osteomyelitis 6 months after treatment of necrotic canal with RC2B. Areas of necrotic bone within dense inflammatory infil-
trate. C, Apical cyst developing 6 months after treatment of necrotic canal with RC2B. Note epithelial lining within dense inflammatory infil-
trate. Reproduced with permission from Newton CW et al.258
Figure 11-19 One year after treatment of necrotic canal with Figure 11-20 Overfill with RC2B. After 1 year, severe inflamma-
RC2B, large granuloma and strands of proliferating epithelium are tion with necrosis is apparent. Adjacent bone was osteomyelitic.
apparent. Reproduced with permission from Newton CW et al.258 Reproduced with permission from Newton CW et al.258
A B
Figure 11-24 A, Scanning electron micrograph view of dentin smear layer. Top half of photo is smear. Lower half of cut surface shows
occluded tubuli. B, Smear layer (left) after canal preparation. Note packed debris and extensions into tubuli. (Courtesy of Drs. Martin
Brnnstrm and James L. Gutmann.)
spreader must reach within 1.0 to 2.0 mm of the work- able spreaders. This technique requires a knowledge
ing length (Figure 11-29), an apical stop must be creat- and understanding of the size and shapes created by
ed to resist apically directed condensation, and the different cleaning and shaping instruments, as well as
accessory gutta-percha cones must be smaller in diam- of the spreaders. If the spreader taper is greater than the
eter than the spreader/plugger (see Figure 11-27). canal taper, there will be an apically directed force dur-
Lateral condensation is not the technique of choice in ing condensation that can result in overfill. If the taper
preparations that cannot meet these criteria and not all of the canal is greater than that of the spreader, there is
canals can be shaped to meet these criteria. Before a tendency to displace the master cone coronally during
embarking on the filling process, however, several condensation.
important steps in preparation must first be complet- Allison and his colleagues at the University of
ed: spreader size determination, primary point and Georgia vividly demonstrated the importance of deep
accessory point size determination, drying the canal, spreader penetration. They also pointed out that the
and mixing and placement of the sealer. most important factor affecting the quality of the api-
Spreader Size Determination. Before trying in the cal seal is the shape of the canal, a true tapered prepa-
trial point, it is mandatory to fit the spreader to reach ration that would allow the spreader to nearly reach the
to within 1.0 to 2.0 mm of the true working length and apical terminus. Canals so treated had virtually no api-
to match the taper of the preparation. Spreaders are cal percolation310 (Figure 11-31). Spreaders should
available that have been numbered to match the instru- always be fit into an empty canal (Figure 11-32) to
ment size (Figure 11-30). Therefore, a spreader of the ensure that the force is absorbed by the gutta-percha
same apical instrument size or one size larger is chosen and not the canal walls, which could result in root frac-
so that it reaches to within 1.0 to 2.0 mm but will not ture. After the gutta-percha is placed, and the spreader
penetrate the apical orifice. Not all canals can be is inserted but does not reach the premeasured depth,
shaped to fit the variety of lengths and tapers of avail- condensation of the gutta-percha will occur laterally
A B
Figure 11-33 Length-adjusted gutta-percha points. A, Size 30 gutta-percha point shortened with scissors. Distortion prevents proper place-
ment at apical seal. B, Size 30 gutta-percha point trimmed with scalpel, allowing more perfect apical fit. Reproduced with permission from
Jacobsen EL.314
Tactile Test. The second method of testing the trial is a better criterion of success than either the visual or tac-
point is by tactile sensation and will determine whether tile method.315
the point tightly fits the canal. In the event the apical 3 The trial point radiograph presents the final oppor-
to 4 mm of the canal have been prepared with near par- tunity to check all of the operative steps of therapy
allel walls (in contrast to a continuous taper), some completed to date. It will show whether the working
degree of force should be required to seat the point, and, length of the tooth was correct, whether instrumenta-
once it is in position, a pulling force should be required tion followed the curve of the canal, and whether a per-
to dislodge it. This is known as tugback. Allison and foration developed. It will also, of course, show the rela-
the Georgia group have shown, however, that significant tionship of the initial filling point to the preparation.
tugback in primary gutta-percha point placement is not Occasionally the radiograph shows the point forced
essential to ensure a proper root canal seal.315 well beyond the apex. If this is the case, an incorrect
Again, if the point is loose in the canal, the next larg- working length has been used during instrumentation,
er size point should be tried, or the method of cutting and the operator may have wondered why the patient
segments from the tip of the initial point, followed by complained of discomfort. The overextended point
trial and error positioning, should be used. Care must
be taken not to force the sharp tip of a point through
the foramen.
Patient Response. Patients who are not anes-
thetized during the treatment of a nonvital pulp or at
the second appointment of a vital pulp may feel the
gutta-percha penetrate the foramen. Adjustments can
then be made until it is completely comfortable. This is
a good test when the position of the foramen does not
appear to be accurately determined by the radiograph
or by tactile sensation. Pulp remnants from a short
preparation will cause a sensation of much greater
intensity than periapical tissue. Granulation tissue may
not produce any sensation at all.
Radiograph Test. After the visual and tactile tests for
the trial point have been completed, its position must be
Figure 11-34 Trial point radiograph. Confirmation film indicates
checked by the final testthe radiograph (Figure 11-34). the primary point should be advanced by another 2.0 mm by either
The film must show the point extending to within 1 mm enlarging one more size or trying the next smaller point. (Courtesy
from the tip of the preparation. Radiographic adaptation of Dr. Carl W. Newton.)
A B C
D E F
Figure 11-40 Lateral compaction, multiple-point filling procedure. Spreader has previously been tested to reach to within 1.0 mm of api-
cal constriction. Thin layer of sealer lines canal walls, tip of point is coated with cement. A, Primary point is carried fully to place, to within
1.0 mm of apical stop. Excess in crown is severed at cervical with hot instrument. B, Spreader (arrow) is inserted to full depth, allowed to
remain 1 full minute as gutta-percha is compacted laterally and somewhat apically. C, Spreader is removed by rotation and immediately
replaced by first auxiliary point previously dipped in sealer. D, Spreader (arrow) is returned to canal to laterally compact mass of filling.
Secondary vertical compaction seals apical foramen. E, Spreader is again removed, followed by matching auxiliary point. Process continues
until canal is totally obturated. F, All excess gutta-percha and sealer are removed from crown to below free gingival level. Vertical compaction
completes root filling. After an intraorifice barrier is placed, a permanent restoration with adhesives is placed in crown.
gutta-percha mass and provide a more effective seal straight finger spreaders. Nickel titanium has also
against coronal leakage.325 All of the sealer and gutta- improved flexibility and has been shown to penetrate
percha should then be removed from the pulp chamber to significantly greater depths than does stainless steel
and a final radiograph taken (Figure 11-43). After an in curved canals.326
intraorifice barrier is placed, either a final or temporary In 1955 Ingle drew attention to the discrepancy in
coronal filling should follow. spreader sizes as well as matching gutta-percha points.327
If one follows this techniquelateral compaction of After 35 years of confusion, the ISO/ADA endodontic
cold gutta-percha pointsa number of questions may standardization committee, in 1990, recommended that
arise: What size and style of spreader should be used? spreaders and pluggers be modeled after the accepted
Which accessory gutta-percha points match the standardized instruments and gutta-percha points, No.
spreaders in size and taper? How much force should be 15-45 for spreaders and No. 15-140 for pluggers.
used with a spreader? Can vertical fractures occur? This new attempt to bring order out of chaos would
Spreader Size and Taper. Spreaders are supplied in abandon the old confusing numbering systems (1-10,
multiple shapes, sizes, lengths, and tapers, including D-11, D-11T, ABCD, XF, FF, MF, F, FM, M, etc) and rec-
hand spreaders with a bent binangle shaft, and small ommend that all spreaders, pluggers, and auxiliary
tures with the D-11 hand spreader than with the less their lower incisors fractured at loads less than 5 kg, in
tapered B-finger spreader.333 marked contrast to the maxillary incisors and canines. In
At Melbourne University researchers compared load the lower incisor sample, fractures occurred when only
and strain using hand versus finger spreaders and three accessory points were compacted. Like the Iowa and
found that strains generated by finger spreaders were Melbourne groups, they speculated that vertical root
significantly lower than hand spreaders. They also fractures might not be detected clinically until long after
concurred with the Iowa group when they noted that the fracture was initiated.337 Again at Iowa, the relation-
lateral condensation may lead to incomplete root frac- ship between tooth reduction and vertical fracture was
tures and that these fractures may later lead to full ver- studied to show that vertical root fracture did not occur
tical fractures under the stresses of restoration or mas- in maxillary anterior teeth under a constant force of 3.3
tication.334 Blum described the intracanal pressure kg for 15 seconds until 40% of the total canal width was
developed during condensation as the wedging effect reduced and was always preceded by visible craze lines.338
and measurements graphed from a force analyzer From Greece, Morfis condemned lateral condensa-
device showed that gutta-percha deformation occurs at tion and long post placement as responsible for root
only 0.8 kg for lateral condensation.335 fractures. He reported 17 (3.69%) vertical fractures of
Researchers at the University of Washington found it 480 endodontically treated teeth.339
took 7.2 kg (15.8 lbs) to fracture a maxillary central inci- Using engineering models, a US Air Force group
sor. However, 16% of their maxillary anterior teeth frac- found that lateral condensation required a smaller
tured at loads under 10 kg. They felt that 5 kg (11 lbs) amount of force than vertical condensation to produce
were a safe load for these husky teeth.336 When this the same amount of stress near the apex whereas
same group tested mandibular incisors, they produced the average stress throughout the entire canal was
fractures with only 1.5 kg (3.3 lbs) of load, and 22% of higher for vertical condensation. They felt that the
term lateral condensation may be somewhat of a mis- sured depth in narrowly prepared canals. One must
nomer, and that lateral condensation may be more know, however, that more vertical force will be exerted
likely to produce undesirable stress concentrations against the primary point as the spreader will tend to
than is vertical condensation.340 This was noted earli- catch in the gutta-percha and force it apically (Figure
er at the University of Georgia, when it was stated that 11-45). Overfills occur with greater frequency when the
the force of the spreader is apparently transmitted 1 to vertical force is greater. This also occurs when the
2 mm beyond the spreader tip and molds the points spreader taper is greater than the canal preparation.
and sealer against the walls as it forces them apical- Nickel-titanium spreaders will penetrate to greater
ly.315 Essentially the same thing was noted at the depths and distribute forces more evenly than will stain-
University of North Carolina.341 less steel spreaders in curved canals (Figure 11-46).
Immature Canals and Apices. The immature canal
Nickel-Titanium Spreaders is complicated by a gaping foramen. The apical open-
Studying the distribution of forces in lateral condensa- ing is either a nonconstrictive terminus of a tubular
tion, a US Army group used photoelastic models to canal or a flaring foramen of a blunderbuss shape.
demonstrate that nickel-titanium spreaders induced Every effort should be made to attain the genetically
stress patterns distributed along the surface of curved programmed closure of the foramen that remains open
canals compared to concentrated spikes of stress when because of early pulp death. This can be accomplished by
stainless steel spreaders were used.342 They also point- apexification, a method of recharging the growth poten-
ed out that, because of their flexibility, nickel-titanium tial and restoring root growth and foramen closure.
spreaders penetrated to a significantly greater depth Apexification is discussed thoroughly in chapter 15.
than the stainless steel spreaders in curved canals.343 If apexification fails or is inappropriate, special
Variations of Lateral Compaction. The preceding methods must be used to obturate the canals without
illustration of obturating a straight canal by lateral benefit of the constrictive foramen serving as a confin-
compaction applies with modifications for filling ing matrix against which to condense. Fortunately, in
curved canals, immature open apices, or tubular canals.
Curved Canals. Virtually all canals exhibit some
curvature. Over 40% of maxillary lateral incisors have
a breaking curve in the apical third. Over 50% of the
palatal roots of maxillary first molars curve back to the
buccal. These are examples of the apical curves.
General root curvature is apparent radiographically in
most of the posterior teeth. Many hidden curves to
the buccal or lingual cannot be seen radiographically in
anterior teeth.
Lateral compaction of curved canals can be very
effective in most cases. However, it may be difficult if
not impossible in severely curved, dilacerated, or bayo-
net canals. If smaller, more flexible spreaders cannot
reach within the apical 1 mm, or the taper of the prepa-
ration is less than that of the spreader, then lateral con-
densation is not the technique of choice. Teasing a flex-
ible primary point smaller than size 30 to place at the
apex, or expecting a stiff spreader to reach within 1 mm
of the working length precludes the use of proper later-
al compaction. There are other techniques that use
warmed or thermoplasticized gutta-percha that are
more applicable. They will be discussed subsequently.
In the vast majority of curved canals, where lateral
compaction is applicable, the routine is exactly the
same: sealer placement and primary point placement, Figure 11-45 Lateral compaction of primary gutta-percha point
followed by spreaders and auxiliary points. Alternating in curved canal. Spreader catches into point, forcing it apically.
spreader sizes is usually required to reach the premea- Extra vertical compaction must be compensated for.
B
Figure 11-50 Chloroform dip technique. A, Note that just the tip is
Figure 11-49 Trial point radiograph of tailor-made gutta-percha immersed and for only 1 second. B, Final compaction of tubular
point. Space exists alongside this roll, which indicates it should be canal. Warm gutta-percha/vertical compaction is preferred technique
enlarged and retested. for cases with such thin walls. (Courtesy of Dr. Carl W. Newton.)
Figure 11-52 Cross-sections of an in vitro study, demonstrating the efficacy of lateral compaction of cold gutta-percha points, each point
a different color. A, Single primary point 1.0 mm from apex apparently fills canal. B, First auxiliary point added following distortion of mas-
ter point, 2.0 mm from apex. C, Second and third auxiliary points 3.0 mm from apex. Canal still totally obturated. D, Second, third, and
fourth points fill canal. Primary point not visible. Small amount of sealer at 4 oclock and 7 oclock positions 4.0 mm from apex. E, Fifth
point joins other; master point does not show. Small amount of sealer at 5 oclock and 7 oclock 5.0 mm from apex. F, Sixth point added;
master point reappears 6.0 mm from apex. G, Seventh point in place, no sealer apparent, canal totally obturated, 7.0 mm from apex.
Reproduced with permission from Sakhal S et al.382
Figure 11-53 Comparative results of lateral compaction following well-compacted versus poorly compacted root canal fillings. A, Complete
healing 1 year after treatment despite overfilling with gutta-percha. (Spaces are artifacts). B, Periradicular granuloma developing 75 days fol-
lowing poorly compacted root filling. Bacteria and necrotic debris left in canal. Reproduced with permission from Malooley J et al.345
the use of a solvent to soften the primary gutta-percha To begin the obturation by lateral compaction, one
point in an effort to ensure that it will better conform must immediately position the customized master
to the aberrations in apical canal anatomy. This is a point to its full measured length and then spread it
variation of a very old obturation method, the so- aside to allow the softened gutta-percha to flow. The
called Callahan-Johnston technique first promulgated spreader is rotated out and is followed by additional
by Callahan in July of 1911.383 The problem with the points, spreader and points. Because 2.0 mm of the
original technique centered around the use of too master tip have been solvent softened, it will flow to
much of the chloroform solvent. Price, a foe of place to produce smooth, homogeneous, well-con-
Callahan, set out to prove how ineffective the Callahan densed gutta-percha fills closely adapted to the internal
root fillings were.384 Although Callahan claimed that canal configuration in the apical third, including the
the mixture of chloroform, rosin, and gutta-percha did filling of lateral canals, fins, and irregularities.385 An
not shrink, Price observed a 24% decrease in volume in Israeli group warns, however, that the point should be
vitro. The chloroform had evaporated leaving pow- positioned and spread within 15 seconds of being soft-
dered gutta-percha. ened; otherwise, it will have lost its plasticity. After 30
Todays use of solvents is quite modest in compari- seconds of air drying, it changes shape.386
son with the older methods. Usually only the tip of the The principal solvent used in this technique is chlo-
point is dipped in the solvent and then only for 1 sec- roform. At one time there was concern that it was car-
ond (see Figure 11-50, A). Two or three dips will cause cinogenic, but it has recently been cleared for clinical
serious leakage.385 use in dentistry by the FDA, Occupational Safety and
In this technique the primary point is blunted and Health Administration, and ADA.387 In any event,
fitted 2.0 mm short of the working length. It is then other solvents such as eucalyptol, halothane, xylene,
dipped in the solvent for 1 second and set aside while and rectified turpentine have been evaluated as substi-
sealer is placed in the canal. This allows the solvent to tutes for chloroform.388
partially evaporate. Too much solvent, as with a two- or In addition to the popular dip technique, sealers are
three-dip method, will materially increase leakage. Not prepared by dissolving gutta-percha in these solvents as
only does the gutta-percha volume shrink as the sol- well as in rosin and balsam. These mixtures have long
vent evaporates in the canal, the sealer leaks as well, been popular as sealers and dips for gutta-percha points.
probably because of solvent dissolution.385 Such mixtures are called chloropercha, Kloropercha, or
A B C
Figure 11-54 Compaction results from three methods of obturation purposely done without sealer. A, Chloropercha filling presents best
immediate appearance. Unfortunately, a 12.4% shrinkage follows, leading to massive leakage. B, Lateral compactioncold gutta-percha
showing coalescence of primary and accessory points at apex but separating midcanal. C, Warm gutta-percha/vertical compaction. Filling is
homogeneous; replication is excellent. Reproduced with permission from Wong M et al.409
eucapercha. Sealers such as CRCS (Calciobiotic Root Halothane and eucalyptol, as alternatives to chloro-
Canal Sealer) and Wachs Sealer, respectively, contain the form, were found to be no better in dissolving or seal-
solvents oil of eucalyptol and Canada balsam. ing ability.395397 However, Morse and the Temple
Efficacy of Solvent-Customized Gutta-percha University group used eucapercha as a sealer and noted
Master Points. As the University of Washington that it shrinks less than warm gutta-percha or gutta-
group noted, customizing master points with solvents percha/chloropercha.398
improves the seal of gutta-percha.385 At the University A Tel Aviv group summarized best the value of cus-
of Iowa, researchers found essentially the same tomized master points softened by solvents. They
thing.389 Peters found virtually no solubility in distilled found that chloroform-dipped points provided a sig-
water after 2 years when the chloroform dip method nificantly better seal than standardized points when
was used with lateral compaction.389a obturating flat canals.399 Few canals are perfectly
Goldman found Kloropercha as a sealer superior to round in shape.
chloropercha or lateral compaction with ZOE sealer.390
Kloropercha contains balsam, rosin, and zinc oxide in Vertical Compaction of Warm Gutta-percha*
addition to gutta-percha and chloroform, which makes Over 30 years ago, Schilder introduced a concept of
it more homogeneous. The US Army Research Institute cleaning and shaping root canals in a conical shape and
also tested chloropercha and Kloropercha. Initially, with then obturating the space three-dimensionally with
the solvent/gutta-percha filling, they achieved dramatic gutta-percha, warmed in the canal and compacted ver-
results (Figure 11-54, A). After 2 weeks, however, tically with pluggers.400 It was his contention that all the
chloropercha shrank 12.42% and the Kloropercha portals of exit were clinically significant and would be
4.68%, whereas the simple chloroform dip shrank only obturated with a maximum amount of gutta-percha
1.4%. The comparative results versus lateral and vertical and a minimum amount of sealer (Figure 11-55).
compaction were dramatic391 (Figure 11-54, B and C).
Morse and Wilcko recommend eucalyptol as a sol-
vent to form euchapercha. It shrinks 10% less than
chloropercha.392,393 Others found the quick-dip tech- *John West gratefully acknowledges the assistance of Herbert
nique superior to euchapercha as a sealer.394 Schilder and James Clark in preparing this section.
A B
Figure 11-56 Comparison in shape and size between pulp and traditional gutta-percha cones. A, Conical pulp extirpated from 10-year-old
boy. Note enormous lateral canal. B, Traditional (nonstandardized) gutta-percha cone similar in taper and bulk to pulp anatomy. (Courtesy
of Dr. John D. West.)
A B C
Figure 11-57 Fitting the master gutta-percha cone. A, Cone fit to radiographic terminus. B, Cone is cut back 0.5 mm. When placed to depth,
the incisal reference remains the same. C, Compaction film reveals two apical foramina as well as large lateral canal opposite lateral lesion.
(Courtesy of Dr. John D. West.)
plugger to capture the maximum cushion of warm should be recorded by plugger number and depth of
gutta-percha as the heat wave is carried apically.405 penetration. The pluggers are then set aside for imme-
Only one or two pluggers may be needed for shorter diate use.
teeth, whereas three or four are used in longer canals. Heat Transfer Instrument. Initially, an instrument
Most cases require three graduated sizes. designed much like a spreader was used to transfer heat
Schilder pluggers are marked with serrations every 5 from a Bunsen burner to the gutta-percha. It was heated
mm, so that the depth that each instrument penetrates cherry-red, immediately carried into the canal, sub-
A B C
Figure 11-58 Warm gutta-percha conforming to egg-shaped canal. A, Primary gutta-percha cone fits 0.5 to 1.0 mm short of radiograph-
ic apex. B, Cold plugger advances the thermoplasticized gutta-percha into apical constricture. C, Vertical pressure compacts warmed
gutta-percha into nonround foramen. (Courtesy of Dr. John D. West.)
and creates a platform to begin the first wave of syringes, such as Obtura II (Obtura/Spartan, USA).
compaction. In any event, the plasticized gutta-percha must be
9. Using the widest vertical plugger that has previous- compacted with vertical pluggers to ensure its flow
ly been coated with cement powder as a separating against canal walls, to weld it to the apical materials,
medium, the gutta-percha is folded into a mass and and to minimize shrinkage (Figure 11-61, S).
compacted in an apical direction with sustained 5- 17. The final act involves the thorough cleansing of the
to 10-second pressure (Figure 11-61, H). This is the pulp chamber below the CE junction, the addition
first heat wave. The temperature of the gutta-percha of an appropriate barrier, and the placement of a
has been raised 5 to 8C above body temperature, permanent restoration (Figure 11-61, T). In molar
which allows deformation from compaction. At this teeth, extra sealer should be placed in the chamber
temperature (42 to 45C), the gutta-percha retains area, warm gutta-percha is syringed into the cham-
its same crystalline beta form with minimal shrink- ber flow, and the gutta-percha is compacted with
age as it cools back to body temperature. large amalgam pluggers to ensure that any furcal
10. The second heat wave begins by introducing the portals of exit will be filled prior to final restoration
heat carrier back into the gutta-percha, where it (Figure 11-62).
remains for 2 to 3 seconds (Figure 11-61, I) and,
when retrieved, carries with it the first selective Like all dental techniques, vertical compaction of
gutta-percha removal (Figure 11-61, J). warm gutta-percha is technique sensitive. It is impera-
11. Immediately, the midsized coated plugger is sub- tive, therefore, to seek professional training in this spe-
merged into the warm gutta-percha. The vertical cial obturation method.407
pressure also exerts lateral pressure. This filling Efficacy of Vertical Compaction of Warm Gutta-
mass is shepherded apically in 3 to 4 mm waves cre- percha. Warm gutta-percha, vertically compacted,
ated by repeated heat and compaction cycles has proved most effective in filling the canals of severe-
(Figure 11-61, K). ly curved roots and roots with accessory, auxiliary, or
12. The second heating of the heat carrier warms the lateral canals, or with multiple foramina. Since the first
next 3 to 4 mm of gutta-percha and again an indication of such anatomic variations may be
amount is removed on the end of the heat carrier observed during the filling procedure, it behooves the
(Figure 11-61, L). dentist to use a filling technique that ensures obtura-
13. The narrowest plugger is immediately inserted in tion in case such unusual canals are open and patent.
the canal and the surplus material along the walls is The chief proponents of the warm gutta-percha
folded centrally into the apical mass so that the heat technique at Boston University point out that consis-
wave begins from a flat plateau. The warmed tent success in obturation will be achieved only when
gutta-percha is then compacted vertically, and the the canal is properly cleaned and shaped, and when
material flows into and seals the apical portals of copious amounts of sodium hypochlorite are used to
exit (Figure 11-61, M). flush away the debris, bacteria, and dentinal filings.408
14. The apical down-pack is now completed, and if a After this proper preparation, predictable three-dimen-
post is to be placed at this depth, no more sional obturation with vertical compaction is easily
gutta-percha need be used (Figure 11-61, N). accomplished. In this technique, the two concepts,
15. Backpacking the remainder of the canal completes cleaning and shaping and three-dimensional obtura-
the obturation. The classic method of backpacking tion, are inseparable.
consists of placing 5 mm precut segments of As previously stated, very few microleakage studies
gutta-percha in the canal, cold welding them with have been done comparing warm gutta-percha/vertical
the appropriate plugger to the apical material compaction with other techniques. Lateral compaction
(Figure 11-61, O), warming them with the heat-car- is usually used as a control in these studies. The few
rier (Figure 11-61, P), and then compacting. It that do exist, however, speak favorably for warm/verti-
should be noted that no selective removal of cal compaction.
gutta-percha is attempted in the backpacking Brothman compared lateral and vertical techniques
(Figure 11-61, Q). This sectional procedure is con- and found no statistically significant difference in filling
tinued with heat and the next wider plugger until efficiency.356 He reported, however, a significantly greater
the entire canal is obturated (Figure 11-61, R). incidence of accessory canal filling with sealer by vertical
16. An alternative method of backpacking may be done compaction. He concluded that ribbon-shaped canals
by injecting plasticized gutta-percha from one of the were better filled by lateral compaction, whereas for cen-
tric canals, vertical condensation appears better.356 inclusions scattered randomly throughout the root
Reader and Himel reported significantly more gutta-per- canal.410 A US Army group tested three different meth-
cha in the lateral canals when compared with cold lateral ods and found the differences in radioactive microleakage
or warm lateral/vertical compaction.357 Torabinejad et al. to 45Ca were not significant.353
compared a number of obturation techniques and con- A tendency to overfill the canal while using the
cluded that comparable results were achieved with all four warm gutta-percha/vertical compaction technique was
methods, but reported close adaptation in the middle and noted by a Lebanese group who reported that apical
apical thirds by the vertical method.358 Wong et al. report- cone displacement was greater with vertical com-
ed a homogeneous filling with excellent replication.409 At paction. Clinically, they observed that overextension
Dalhousie University, three obturation methods were is more likely to occurwhen the master cone is
compared and all three techniques proved equally satis- adapted only 0.5 mm short. There were no overexten-
factory, although the researchers did note cold-welds sions with lateral compaction.411
with vertical compaction.352 Lugassey and Yee also noted Schilder has twice reported to meetings of the
the cold welds as well as microscopic voids, folds and American Association of Endodontists his evaluations
Figure 11-61 Technique of warm gutta-percha/vertical compaction. A, Master gutta-percha cone fits tightly to radiographic apex. Marked
at incisal edge to establish length reference. B, Master cone cut back 0.5 to 1.0 mm at tip and retried in canal. Trimmed incisal reference
remains same. C, Largest plugger prefit to coronal third of canal. D, Midsize plugger prefit to midcanal without touching walls. E, Smallest
plugger prefit to within 3 to 4 mm of radiographic apex. Remains free in canal. F, Kerr Sealer deposited in midcanal with Handy Lentulo spi-
ral. Apical third of master cone is lightly coated with sealer and gently teased to place. Incisal reference checked. G, Surplus gutta-percha
removed with heat carrier down to canal orifice. H, Largest plugger compacts warmed gutta-percha into bolus. Midroot lateral canal being
obturated. I, Heat carrier transfers heat 3 to 4 mm into middle third of mass. Wiping carrier against walls softens excess gutta-percha. J, First
selective gutta-percha removal.
of success and failure when his recommendations of partially healed (75%), no healing (50%), or worse. Total
cleaning and shaping and obturation with warm healing or 90% healing was noted in 56% of the cases
gutta-percha and vertical compaction were followed. within the first 6 months. At 24 months, 99% of the 100
The cases were done by endodontic graduate students cases were fully healed.412 The one failed case (an
at Boston University. 84-year-old woman) was subsequently revealed by sur-
The first was a radiographic study, treatment of 100 gery to have an apical bifurcation. Apicoectomy below
maxillary anterior teeth with periradicular lesions.412 the bifurcation allowed normal healing within 1 year.
The lesions ranged in size from 8 to 35 mm. The age On the basis of this radiographic study of maxillary
range was 14 to 84 years and involved both sexes. anterior teeth, Schilder reported 100% success after 2
Radiographic observations were made at 6, 12, 18, and years for cleaning and shaping and three-dimensional
24 months. Healing was judged as totally healed (90%), obturation by warm gutta-percha/vertical compaction.412
Figure 11-61 (Continued) K, Midsize plugger compacts heat-softened gutta-percha apically. Second lateral canal appears as obturated. L,
Heat transfer instrument warms apical gutta-percha. Second selective removal of material. M, Smallest plugger compacts apical mass into
apical preparation and accessory canals now appear obturated as well. N, Plugger folds surplus gutta-percha around walls into flattened cen-
tral mass. Radiograph confirms total obturation of apical third of canal. If a post is to be placed, obturation is complete. O, To complete obtu-
ration by segmented gutta-percha, a 3 mm blunted section is placed and cold-welded with the medium plugger to the apical mass. P, Heat
carrier warms first backpack piece. Q, Warmed backpack piece married by compaction to apical filling. Process is continued to fill entire
canal. R, If gutta-percha gun (Obtura II) is used for backfill, the needle is inserted to the apical segment and then backed out, leaving deposit.
Plasticized gutta-percha is compacted to complete obturation to canal orifice. S, Final compaction of backpack done with largest plugger. T,
Gutta-percha and sealer are removed to below free gingival level, crown is thoroughly cleansed, and final restoration is placed in the coronal
cavity. (Courtesy of Dr. John D. West.)
device for warming gutta-percha in the canal, positioned in the backfill space in the canal. The System
Buchanan and Analytic perfected the System-B Heat B temperature is now set at 100C. Preheat the plugger
Source and associated pluggers (SybronEndo/Analytic; out of the canal for only 14 second, cut the heat, but
Irvine, Calif.). This new heat source monitors the tem- immediately plunge the plugger into the backfill cone
perature at the tip of the heat-carrier pluggers, thus and hold it in place for 3 to 5 seconds as the gutta-per-
delivering a precise amount of heat for an indefinite cha cools. Another cone is added in the backfill space
time.419 and heat is again applied. The final plugging is done
System B obturation is predicated on a precise with a large cold regular plugger. Another method of
preparation, perfectly tapered to match as closely as backfilling is to use the Obtura II gutta-percha gun.
possible the shape of the nonstandardized gutta-percha To date there have been few reports on the success of
cones-fine, fine-medium, medium, and medium-large the System B Technique. On the other hand, concern
(F, FM, M, and ML). Another Buchanan/Analytic has been expressed about the 200C heated plugger so
development is gutta-percha cones that match the near the thin root at the apex. The short period of time
shape produced during canal preparation using this high heat is delivered, however, seems to preclude
Greater Taper instruments. any periodontal damage.
Downpack Technique. An appropriate size gutta- Warm/Sectional Gutta-percha Obturation. The
percha cone, matching the completed preparation use of small warmed pieces of gutta-percha, the
shape, is tested in the canal to be sure it goes fully to so-called sectional obturation technique, is one of the
place. This is confirmed radiographically. Continuous earliest modifications of the vertical compaction
Wave Technique requires good canal shape and metic- method described earlier. Webster might well have
ulous gutta-percha cone fitting. The cone must fit in its been describing this procedure in 1911 when he spoke
last 1 mm, and fit to full length before minimal cutback about filling with gutta-percha, using points heated
(less than 0.5 mm).419 The cone is then removed and and well packed in with hot instruments.228
the corresponding plugger is tried for size in the canal. Eventually this became known as the Chicago tech-
It should stop at its binding-point, about 5 to 7 mm nique since it was widely promoted by Coolidge,
short of the working length. The stop attachment is Blayney, and Lundquist, all of Chicago. It was also the
then adjusted at the coronal reference point and the favorite technique of Berg of Boston.420
plugger is removed and attached to the Heat Source. The method begins like other methods: fitting the
The canal is dried. plugger to the prepared tapered canal (Figure 11-63,
The primary point is coated with sealer and pushed A). It should fit loosely and extend to within 3 mm of
into place, all the way to the apical stop. The Heat the working length. A silicone stop is then set on the
Source is activated, set for use and touch, and the shaft marking this length (Figure 11-63, B). Next, the
temperature is set for 200C and the power dial at 10. primary gutta-percha point is blunted and carried to
The cone is then seared at the orifice with the preheat- place. It should be fitted 1 mm short of the working
ed plugger tip, and the preheated plugger is then driv- length and confirmed radiographically (Figure 11-63,
en smoothly through the gutta-percha to within 3 to 4 C). Upon removal, 3 mm of the tip of the point are
mm of its binding point in the canal. This will take cleanly excised with a scalpel (Figure 11-63, D) and this
about 2 seconds. Maintaining apical pressure, the plug- small piece is then luted to the end of the warmed plug-
ger will continue to move apically, and at this time the ger (Figure 11-63, E). Sealer is placed, lining the canal,
heat switch is released. The plugger is held there, cold, the gutta-percha tip is warmed by passing it through an
under sustained pressure, for an additional 10 seconds. alcohol flame, and it is then carried to place. Under api-
It is during this period the gutta-percha flows to the cal pressure, the plugger is rotated to separate the
apical matrix and into accessory canals. The pressure gutta-percha (Figure 11-63, F) and it is thoroughly
also compensates for the shrinkage that might occur as packed in place. At this point, it is best to expose a radi-
the mass cools. ograph to be sure the initial piece is in position (Figure
To remove the plugger: while still maintaining apical 11-63, G). If so, the remainder of the canal is filled in a
pressure, the heat switch is activated for only 1 second like manner, compacting additional pieces of warmed
followed by a 1-second pause. The cold plugger is then gutta-percha until the canal is filled to the coronal ori-
quickly withdrawn. Following radiographic confirma- fice421 (Figure 11-63, H).
tion, the remainder of the canal is now ready for backfill. If a post is planned, the compaction can stop after the
Backfill Technique. Using the same size gutta-per- second piece, leaving 5 to 6 mm of apical canal filled.
cha cone and plugger, the cone is coated with sealer and Another variation of heat-softening the gutta-percha is
Figure 11-63 Sectional gutta-percha obturation. A, Canal prepared with flare. B, Plugger preselected to fit loosely in canal and extend to
within 3 mm of working length. C, Master gutta-percha point fitted to within 1.0 mm of working length. Confirm by radiograph. D,
Gutta-percha is removed and 3 mm of apical point are excised (arrow). E, Plugger is warmed in alcohol flame and point is luted to plugger.
Gutta-percha is warmed by passing through alcohol flame and quickly coated with cement. F, Warm gutta-percha is carried to place; plug-
ger is rotated to loosen and then used for compaction. G, Radiograph should confirm well-condensed apical filling. H, Remainder of canal
is filled by lateral or vertical condensation, by Compactor or Obtura. (Courtesy of Dr. Ahmad Fahid.)
to soften each piece in chloroform or halothane in a After the primary point is fitted to full working length,
quick dip. the hand spreader and the Endotec plugger/spreader
Rather than laboriously adding sections of are fitted as well. At this point, silicone stops are placed
gutta-percha, backfilling may be done with thermo- to mark the length of canal.
plasticized gutta-percha from one of the gutta-percha After drying of the canal, a limited amount of sealer
guns. In evaluating such backfill, Johnson and Bond is applied. The primary point is then firmly positioned
noted that it may be clinically acceptable to backfill and gently adapted with a hand or finger spreader. It
canals up to 10 mm in a single increment using sealer has also been recommended that one or two addition-
and the Obtura II gutta-percha system.422 al gutta-percha points be placed to reduce the possibil-
Lateral/Vertical Compaction of Warm Gutta-percha. ity that the warm plugger will loosen the point when
Considering the ease and speed of lateral compaction as the tip is retracted.
well as the superior density gained by vertical com-
paction of warm gutta-percha, Martin developed a
device that appears to achieve the best qualities of both
techniques. Called Endotec II (Medidenta Inc;
Woodside, N.Y.), the newly designed device is a battery-
powered, heat-controlled spreader/plugger that ensures
complete thermo-softening of any type of gutta-percha.
It is supplied with two AA batteries that provide the
energy to heat the attached plugger/spreader tips
(Figure 11-64). The quick-change, heated tips are sized
equivalent to a No. 30 instrument, are autoclavable, and
may be adjusted to any access angulation. Martin claims
that the Endotec combines the best of the two most
popular obturation techniques: warm/vertical and the
relative simplicity of lateral compaction (H. Martin,
personal communication, December 1999). Figure 11-64 Endotec II handpiece contains battery power pack.
Canal cleaning and shaping for this technique is a Button initiates heat in attached plugger. (Courtesy of Medidenta,
continuous taper design with a definite apical stop. Inc.)
At this juncture the Endotec plugger is placed in the measurably improve compaction while obturating a
canal to full depth. The activator button is pressed and mandibular molar with a C-shaped canal by using the
the heating plugger is moved in a clockwise motion. EndoTec in what they termed a zap and tap maneu-
The heat button is then released and the plugger cools ver: preheating the Endotec plugger for 4 to 5 seconds
immediately. It is now removed from the gutta-percha before insertion (zap) and then moving the hot instru-
with a counterclockwise motion. This lateral com- ment in and out in short continuous strokes (taps) 10
paction has formed a space for an additional point to to 15 times. The plugger was removed while still hot,
be added, after which the plugger is again placed, heat- followed by a cold spreader with insertion of addi-
ed, moved clockwise for 10 to 15 seconds, cooled, and tional accessory points.423
retracted counterclockwise (Figure 11-65). Now the Concern has been voiced that heat from the tip will
plugger can be used cold to compact the softened damage the periodontium, and that the lateral/vertical
gutta-percha, followed again by warming and lateral pressure exerted will be too stressful. In the first instance,
space preparation for additional points. it was found there was no heat related damage to peri-
In this manner (lateral compaction with the heated odontal tissues from either of the two methods
plugger to provide space for additional gutta-percha, employed: Endotec and warm/vertical compaction.424
and the vertical compaction with the cooled plugger to A US Army group also tested for heat damage from the
condense the heat-softened gutta-percha) the canal is Touch n Heat unit, which produces more heat (816C)
entirely obturated. Finally, a cold hand plugger can be than the Endotec. They pointed out that even though the
used to firmly condense the fused gutta-percha bolus. internal gutta-percha mass reached 102C, gutta-percha
The Endotec can also be used to soften and remove and dentin are poor heat conductors, and this tempera-
gutta-percha for post preparation or in the event of re- ture would not be of sufficient magnitude to cause
treatment. An Air Force group also found they could damage in the periodontal tissues.425
In the second instance, that of stress development,
Martin and Fischer have shown, in a photoelastic stress
test, that warm lateral condensation (Endotec) created
less stress during obturation than did cold lateral con-
densation.373
Efficacy of the Warm/Lateral Technique. Because
gutta-percha is heated with this technique, there must
be a commensurate shrinkage when it cools. This fact
alone would bring into question the density of the final
filling. However, Martin point out that the Schilder
compaction method leads to 0.45% shrinkage, and
since Endotec temperatures are lower than with the
other technique, shrinkage following Endotec usage
should be lower as well.426
A US Army group evaluated the quality of the apical
seal produced by lateral versus warm lateral com-
paction and found no significant difference in leak-
age.359 In contrast, Kersten, in Amsterdam, reported
that Endotec had significantly less leakage than any of
four other methods.372 Ewart and Saunders, in
Glasgow, found much the same.427
Himel and Cain, at Tennessee, achieved the best
result with the Endotec if they condensed the
gutta-percha bolus five times with the cold plugger
after each warming with the plugger heated. This prac-
tice filled lateral and accessory canals as well: the
gutta-percha was not melted but soft enough it would
Figure 11-65 Motion for using Endotec II- plugger/spreader
flow into fins and ramifications.428 A US Army group
vertical pressure with sweeping lateral pressure. Additional
gutta-percha points will be added. (Courtesy of Dr. Howard reported they could improve the density (by weight) of
Martin.) laterally compacted canals by 14.63% by a follow-up
use of the Endotec. A second use added another 2.43% However, problems developed and the Compactor fell
of gutta-percha.429 into disfavor. Fragility and fracture of the instruments,
As far as tissue reactions to the technique are con- along with overfilling because of the difficulty in master-
cerned, Castelli et al. found that some Endotec speci- ing the technique, led to its demise. However, phoenix-
mens generated small restrictive inflammatory infil- like, it rose again in different shapes and forms. In
trates restricted to the root canal opening, whereas the Europe, Maillefer modified the Hedstroem-type instru-
warm gutta-percha vertical condensation inflamma- ment as the Gutta-Condenser, and Zipperer (Germany)
tory reactions, because of their extensive nature, were called its modification the Engine Plugger. The latter
probably the source of maintaining discomfort and more closely resembles an inverted K-file.
pain.424 McSpadden, in the meantime, modified his original
Thermomechanical Compaction of Gutta-percha. patent and brought out a newer, gentler, slower-speed
A totally new concept of heat softening and compact- model. It is now supplied as an engine-driven instru-
ing gutta-percha was introduced by McSpadden in ment made of nickel titanium (see Figure 11-66) and
1979. Initially called the McSpadden Compactor, the presented as part of the Microseal System (Analytic/
device resembled a reverse Hedstroem file, or a reverse Quantec, USA). Because of their flexibility, the NiTi con-
screw design. It fit into a latch-type handpiece and was densers may be used in curved canals.
spun in the canal at speeds between 8,000 and 20,000 The Microseal Condenser is used in conjunction
rpm. At these speeds, the heat generated by friction with heat-softened, alpha phase-like gutta-percha as
softened the gutta-percha and the design of the blades well as regular gutta-percha points. Of course, sealer is
forced the material apically. In experienced hands, always used. To obturate a canal, the clinician is advised
canals could be filled in seconds. to place the primary gutta-percha point, followed by
the appropriate size Condenser (one that will reach
near the working length), which has been coated with
the heat-softened gutta-percha (Figure 11-67). The
Condenser is spun in the canal with a controlled speed
handpiece at 1,000 to 4,000 rpm to form a firmer core.
This flings the gutta-percha laterally and vertically
(Figure 11-68).
McSpadden has developed a technique to fill
open-apex cases as well by initially depositing a bolus
of low-heat gutta-percha at the apex with a large con-
denser. This is allowed to cool and harden to form an
apical plug against which the remaining canal is obtu-
rated with gutta-percha points and additional
heat-softened gutta-percha.430
To date, this particular techniquecombining the
reverse screw-type condenser with warmed alpha
gutta-perchahas not been widely reported in US lit-
erature; however, the technique is popular in Europe,
with some reporting from there.
Efficacy of the Thermomechanical Compaction
Method. The original McSpadden compactor was
well studied in the 1990s, and these findings are not
totally moot because a modification is being distributed
as the Brasseler TLC (Thermal Lateral Condensation) as
well as the aforementioned European models, the
Maillefer Gutta-Condensor and the Zipperer Engine
Plugger. These instruments have enjoyed a good deal of
use, particularly for backfilling after the initial vertical
Figure 11-66 Micro-Seal Gutta-percha Condenser is operated at
slow speed. The reverse-screw action compacts plasticized or lateral compaction is complete.
gutta-percha apically and laterally. (Courtesy of SybronEndo/ This latter method has been termed the hybrid tech-
Analytic-Quantec.) nique by Tagger et al. of Tel Aviv.375 They first coat their
A B
Figure 11-68 A, Remarkable flexibility of nickel-titanium condenser allows careful rotation in curved canals at very slow speed. B, Final fill-
ing by Condenser. (Courtesy of Dr. John McSpadden.)
cation of a spinning compactor could produce this hand, they make a case for the less aggressive method:
much rise in temperature.433 Saunders, also at Dundee, slower-speed, lower-temperature plasticized gutta-per-
performed in vivo hyperthermia studies on ferrets cha that can be placed with less stress to the tooth, yet
using an Engine Plugger at 10,000 rpm. He found a provide optimal obturation.
median 18.31C temperature rise during use, which Thermomechanical Solid-Core Gutta-percha
then dropped to a 1.25C rise in 1 minute.434 He also Obturation. One other innovation using the thermo-
examined these specimens histologically 20 days after mechanical principle to compact gutta-percha in the
testing and found resorption of cementum in 20% of root canal has been introduced as the J.S. Quick-Fill
the specimens. At 40 days he found about 25% exhibit- (J.S. Dental Co., Sweden/USA). This system consists of
ed resorption as well as ankylosis of bone to cementum titanium core devices that come in ISO sizes 15 to 60,
and sounded a note of caution.435 resemble latch-type endodontic drills, coated with
In Sweden, with workers using the compactor for 8 alpha-phase gutta-percha (Figure 11-69). These devices
seconds, temperature increases as much as 50C (35C are fitted to the prepared root canal and then, following
mean) were recorded. They, too, felt that periodontal the sealer, are spun in the canal with a regular
complications from thermomechanical condensation are low-speed, latch-type handpiece. Friction heat plasti-
possible.436 At the University of Florida, a group stated cizes the gutta-percha and it is compacted to place by
that higher speeds or longer duration than recommend- the design of the Quick-Fill core. After compaction,
ed could cause an adverse temperature riseand a there are two choices: either the compactor may be
detrimental effect upon the quality of the seal.437 removed while it is spinning and final compaction
These outer-limit studies lead one to conclude that completed with a hand plugger or the titanium solid
care must be used, kinder and gentler, in any of these core may be left in place and separated in the coronal
mechanical, heat-generating methods. On the other cavity with an inverted cone bur.
Pallares and Faus, from Valencia, Spain, conducted
an apical leakage dye study comparing J.S. Quick-Fill
against lateral condensation. They found no significant
difference in efficacy; however, they did find with the
J.S. Quick-Fill that the sealer (AH26) adapted more
peripherally against the dentin walls and the gutta-per-
cha was more centrally located. The cement had also
penetrated the dentinal tubules and the lateral and
accessory canals.438 Canalda-Sahli and his coworkers,
also from Spain, found that J.S. Quick-Fill could be
used successfully to seal root canals in teeth with large
straight canals.439
Ultrasonic Plasticizing. The technique of plasticiz-
ing gutta-percha in the canal with an ultrasonic instru-
ment was first suggested by Moreno from Mexico.440
He used a Cavitron ultrasonic scaler (Dentsply/Caulk;
Milford, Dela.) with a PR30 insert, but because of its
design it could be used only in the anterior mouth.
Moreno placed gutta-percha points to virtually fill the
canal. He then inserted the attached endodontic instru-
ment into the mass, activated the ultrasonic instrument
(without the liquid coolant), and as it plasticized the
gutta-percha by friction, advanced it to the measured
root length. Final vertical compaction could be done
with hand or finger pluggers.440
At San Antonio, workers questioned the heat gener-
Figure 11-69 J.S. Quick-Fill titanium carriers coated with
alpha-phase gutta-percha comes in four sizes and operates in regu-
ated by this technique. Would it be damaging? Using the
lar slow-speed handpiece. Friction plasticizes gutta-percha. Cavitron PR30, they found very little heat rise: 6.35C in
Titanium core may be severed and left or removed while still spin- 6.3 seconds. Using an Enac ultrasonic unit (Osada Co.;
ning. (Courtesy of J.S. Dental Mfg. Co.) Los Angeles, Calif. and Japan), however, they recorded a
Figure 11-70 Comparison in obturation between hand-lateral compaction and ultrasonic compaction. Left, Accessory point folded in
canal during lateral compaction following finger spreading. G, individual gutta-percha points. C, canal wall. High power (320 original mag-
nification). Center, Gutta-percha compacted by Enac ultrasonic spreader tips (no fluid coolant.) Note uniformity of gutta-percha mass with
only two crevice marks (A). C denotes canal walls. High power (320 original magnification). Right, Low power (10 original magnifica-
tion) of apical third obturation by ultrasonic. B marks well-filled foramen. Rectangular area is seen at high power in center panel. Reproduced
with permission from Baumgardner KR and Krell KV.442
19.1C rise in temperature because it took 141 seconds size has been reduced to either 20 gauge (equal to a size 60
to plasticize the mass. They felt the heat generated by file) or 23 gauge (equal to a size 40 file) (Figure 11-72).
the Cavitron would not be harmful.441 Although regular beta-phase gutta-percha is still
At the University of Iowa, on the other hand, a group used, the clinician can now choose a less viscous, high-
was quite impressed with a technique using an Enac er flow form of gutta-percha known as Easy Flow
ultrasonic unit (Osada) with an attached spreader. (Charles B. Schwed Co.; Kew Gardens, N.Y.).
Unlike the University of Texas group, however, they did Gutmann and Rakusin, leading proponents of
not attempt to plasticize the gutta-percha. They felt the thermoplasticized gutta-percha obturation, have
spreader more easily penetrated the mass of gutta-per- emphasized the importance of properly preparing
cha than did the finger spreaders, and that in the end, the canal to receive the injection needle and com-
the energized spreading technique led to a more pacting the warm gutta-percha. They point out the
homogeneous compaction of gutta-percha with less importance of preparing a continuously tapering
stress and less apical microleakage442 (Figure 11-70). funnel from the apical matrix to the canal orifice.446
Thermoplasticized Injectable Gutta-percha Obtur- They especially note the significance of properly
ation. An innovative device, introduced to the profes- shaping the transitional area from the apical third to
sion in 1977, immediately caught the fancy of dentists the middle third, particularly in curved canals
interested in the compaction of warm gutta-percha. (Figure 11-73), and warn against the development of
Developed by a group at Harvard/Forsyth Institute, the coke-bottle canals so frequently seen following
gutta-percha was ejected out of a prototype pressure Gates-Glidden canal preparations (Figure 11-74).
syringe that had warmed it to 160C. At this temperature, The tapered preparation enhances the flow of the
the gutta-percha would flow through an 18-gauge nee- plasticized material, whereas the Coke-bottle prepa-
dle.443 From this early model, a more efficient system was ration negates the flow.446
developed and patented.444,445 Today, through further A definitive apical matrix is also important. This
improvements, the device is marketed as the Obtura II constriction prevents the extrusion of filling material
Heated Gutta-Percha System (Obtura-Spartan Corp., into the periapex (see Figure 11-73). Preparations to
Fulton; Mo.) (Figure 11-71), with digitally controlled tem- size 25 or 30 files at the apical terminus, tapered to a
peratures ranging from 160C to 200C while the needle size 60 file at the coronal orifice, have proven perfectly
adequate as long as there is sufficient blending of the Initially, a technique was developed of depositing
coronal preparation with the apical preparation. the warm plasticized gutta-percha well down into the
Methods of Use. Although initially it was hoped canal and then compacting it with hand or finger plug-
that the gutta-percha gun could be used to totally gers to the apical terminus. In using this method, how-
obturate the canal, it soon became apparent that sealer ever, one must be prepared to act as soon as the
and further compaction were necessary. Sealer serves gutta-percha is placed because it cools rapidly and
its usual role of filling the microscopic interface hardens, often within 1 minute; however, the Easy Flow
between the dentin and gutta-percha as well as acting gutta-percha does afford at least 10 to 15 more seconds
as a lubricant. Compaction became necessary to close of working time.
spaces and gaps while forcing the gutta-percha lateral-
ly and vertically. It also compensates for shrinkage as
the gutta-percha cools. Furthermore, the smallest injec-
tion needle, 23 gauge, was too large to reach the apex in
most cases.
Figure 11-73 Gutmann insists that the most critical area of canal
Figure 11-72 Warm plasticized gutta-percha stream extruded preparation is the transition from the apical third to the middle
through needle tip (arrow) of Obtura II. (Courtesy of third of the canal. Reproduced with permission from Gutmann JL
Obtura/Spartan USA.) and Rakusin H.446
Another popular obturation method used by many ing these test teeth was only 1.1C over 60 seconds. This
endodontists is to initially place a fitted master point to appears to be a safe temperature level.450
the apical terminus and follow this with the Obtura Others recorded much higher (137.81C) intracanal
needle-tip, depositing a bolus of warm gutta-percha recordings.451 Hardie recorded a temperature rise of
around the point. This is immediately compacted ver- 9.65C on the external surface of a tooth.452 This
tically and laterally. More plasticized gutta-percha is dropped to 4.75C in 3 minutes and compared with a
then added and compacted. This technique will better 15.38C rise in temperature generated by an Engine
ensure apical closure without overfilling. Plugger compactor spinning at 8,000 rpm.452 Bone
Success with any of these techniques is operator injury has been reported with external root tempera-
dependent. Repeated practice on plastic-block canals as ture rises of 10C if maintained for 1 minute.453
well as extracted teeth is imperative. To gain intraoral Hardies reported 9.65C increase (dropping to 8.20C
experience, one might start by using the device to back- in 1 minute) appears to fall within safe limits.452 Weller
fill other methods before tackling full-treatment cases and Koch evaluated external root temperatures in vitro
and by initially using the system on large, relatively when using gutta-percha thermoplasticized at 200C
straight canals. As a matter of interest, the Obtura II is and additionally found that the rise in temperature was
probably being used more frequently as a backfilling well below the critical level of 10C.454
device than for primary obturation. The efficacy of thermoplasticized gutta-percha in
Efficacy and Safety of the Thermaplastic Injectable filling fins and cul-de-sacs,455 internal resorption cavi-
Gutta-Percha Technique. A number of studies on the ties,456,457 C-shaped canals, accessory canals, and
heat generated by this method have been done. arborized foramina is well documented (Figure 11-76).
Gutmann et al. found in vitro that the gutta-percha All researchers insist, however, that sealer is necessary
emerged from the needle at 71.2C in a body tempera- to prevent microleakage.347,458 Clinical success rates
ture environment.449 with the injection technique have been reported at
In an in vivo study on dogs, the mean intracanal 93.1%.459
temperature of the gutta-percha was 63.7oC. Compared with other techniques, the thermoplasti-
Maximum temperature elevation on the bone overly- cized, regular beta-phase (higher heat) gutta-percha
proved equal to laterally compacted cold gutta-percha third of the canal. If the System B or vertical com-
in a number of studies of microleakage362364 and sig- paction is used, the method already results in an api-
nificantly poorer in others.347,348 Virtually all of the cally compacted segment.
studies reported some overfilling and apical extru- According to the Inject-R Fill technique, the coronal
sions.347,348,362,363 At least one author admitted, how- walls must be resealed with sealer prior to filling the
ever, that his groups results confirmed the opinion of region with gutta-percha from the device.460 The
Gutmann and Rakusin that clinicians should take time Inject-R Fill must first be heated in a flame or an elec-
to master the technique before employing it in the tronic heater and the coronal surface of the gutta-per-
treatment of their patients.347 As with any obturation cha already in the canal should be warmed using a
technique, the efficacy and long-term success of the heated instrument. When a burner is used, the stainless
method are highly dependent on the cleaning and steel gutta-percha filled sleeve is waved through the
shaping of the canal and the resultant degree of reten- flame until gutta-percha begins to extrude from the
tion and resistance form that is developed. open end. The warmed unit is then placed into the ori-
Inject-R FillBackfilling Technique. As stated earli- fice of the canal. For the device to fit, the canal orifice
er, the Obtura II is frequently used in backfilling, a must be at least 2 mm in diameter. A push of the han-
method for completing total canal obturation after the dle toward the canal injects the heated gutta-percha
apical third of the canal has been filled. Another into the canal. The carrier is then rotated to break it
method of backfilling has been developed by Roane at free from the access.
the University of Oklahoma and is marketed as Inject- Prefitted hand or finger pluggers are subsequently
R Fill (Moyco-Union Broach; Bethpage, N.Y.). used to compact the gutta-percha and push the inject-
Inject-R Fill, a miniature-sized metal tube contain- ed mass into contact with the apical segment. The plug-
ing conventional gutta-percha and plunger, simplifies ger must be positioned in the center of the mass and
warmed vertical compaction by altering the backfilling pressed firmly toward the apex. Pressure is sustained
process. The technique allows for delivery of a single for a few seconds before the plugger is rocked from side
backfill injection of gutta-percha once the apical seg- to side and rotated to break it free. As the plugger is
ment of a canal has been obturated (Figure 11-77). removed, a small void is left in the center of the mass.
The apical segment of the canal can be obturated The void is closed by folding over remaining gutta-per-
using any technique including lateral compaction, tra- cha from the sides and packing it apically. This process
ditional warm vertical compaction, or System B. If a is repeated until a larger plugger can be used without
cold lateral technique is used, the cones of gutta-percha creating a void and the gutta-percha mass is firm.
extruding from the canal must first be heat severed at a Coating the tip of each Inject-R Fill with sealer before
sufficient depth so a plugger can be used to compact placing it in the canal will prevent sticking of the gutta-
the remaining heat-softened segment in the apical percha and should enhance the gutta-percha/
sealer/canal interface. According to Roane, the tech-
nique is rapid and produces a result similar to that of
warm vertical compaction (personal communicaton,
April 2000).
An important caveat must be issued, warning any-
one using a system of injection, thermoplasticized
gutta-perchabe very careful not to force or overin-
ject the heat-softened material.461 Disastrous results
may develop if, for example, the softened gutta-percha
is injected into the maxillary sinus or the inferior alve-
olar canal (Figure 11-78).
SOLID-CORE CARRIER: MANUAL INSERTION
ThermaFil (Dentsply/Tulsa)
Densfil (Dentsply/Maillefer),
Soft-Core (Soft-Core System, Inc.), and
Three Dee GP (Deproco UK Ltd.)
Figure 11-77 Inject-R-Fill shows protrusion of heat-softened
gutta-percha prior to its insertion into the canal. (Courtesy of In 1978, Johnson described a unique yet simple
Moyco/Union Broach Co.) method of canal obturation with thermoplasticized
A B
Figure 11-78 A, Plasticized gutta-percha extruded from syringe overfills enormous area of mandible. B, Pathologic specimen of
osteomyelitic bone and chronic inflammation attached to extruded gutta-percha. Reproduced with permission from Gatot A et al.461
alpha-phase gutta-percha carried into the canal on an ThermaFil is a patented endodontic obturator con-
endodontic file.462 What was a curiosity in 1978 has sisting of a flexible central carrier, sized and tapered to
become today a popular and respected technique of match variable tapered files (.04/.06) endodontic files.
canal obturation (Figure 11-79). ThermaFil is consid- The central carrier is uniformly coated with a layer of
ered the major core-carrier technique, and through a refined and tested alpha-phase gutta-percha.463 The
licensing agreement with Dentsply, a duplicate prod- use of the variable tapered files in canal preparation has
uct, Densfil was created. Recently, two similar products enhanced the fit, placement, movement, and com-
were introduced: Soft-Core, and its European version, paction of the gutta-percha delivered by the ThermaFil
Three Dee GP. core carrier. Likewise, the ThermaFil system now
A B
Figure 11-79 A, Original handmade gutta-percha obturator mounted on regular endodontic file. B, Modern manufactured Thermafil
Obturatorsalpha-phase gutta-percha mounted on radiopaque, flexible, plastic carriers. Note silicone stop attachments. A reproduced with
permission from Johnson WB.462 (B courtesy of Dentsply/Tulsa Dental Products.)
Previously, the built-in rubber stop, on the calibrated ers.468 The use of the size verifiers in choosing the cor-
shaft, had been set at the proper length position. The car- rectly sized core carrier has also reduced the incidence
rier is not twisted during placement, and attempts to of material overextension.
reposition the carrier should be avoided to prevent dis- The precurving of ThermaFil obturators is usually
ruption of the gutta-percha that was initially positioned not necessary if the canal is prepared properly, as the
through the compacting action of the core carrier. flexible carrier will easily move around curves. With
Once it is ensured radiographically that the canal this technique, gutta-percha will flow easily into canal
has been filled to the desired position, the shaft is sev- irregularities such as fins, anastomoses, lateral canals,
ered in the coronal cavity. While the handle is firmly and resorptive cavities464,469 (Figure 11-82).
held aside, a No. 37 inverted cone bur is used to trim off Efficacy of ThermaFil Obturation. A nationally
the shaft 2 mm above the coronal orifice. Specific burs recognized evaluator of materials, devices, and tech-
have also been developed for this task: Prepi Bur niques, Clinical Research Associates (CRA), headed by
(Prepost Preparation Instrument) (Dentsply/Tulsa; Christensen, has indicated that ThermaFil allows sim-
Tulsa, Okla.). The Prepi Bur, a noncutting metal ball, is ple, fast, predictable filling of root canals. It was found
run in a handpiece and is also used to create postspace to be especially useful for small or very curved
safely and efficiently when needed. This space can be canals.470 Radiographic assessment of this gutta-per-
created immediately or on a delayed basis without cha delivery technique has been quite favorable,468 and
altering the apical seal.466 recent adaptation studies that have looked at the con-
Johnson has suggested that the final compaction can temporary use of the technique have found it compa-
be improved if a 4 to 5 mm piece of a regular gutta-per- rable to, if not better than, lateral compaction.469,471
cha cone is inserted into the softened gutta-percha and Gutmann et al. and W. P. and E. M. Saunders from
compacted apically and laterally with a large plugger. 464 Glasgow evaluated ThermaFil versus lateral compaction
Gutta-percha accessory points can also be used in a sim- in a series of studies.469,471 They reported that
ilar fashion to achieve a greater depth of material deliv- ThermaFil resulted in more dense and well adapted
ery if the canal is very wide buccolingually. In this case, root canal fillings throughout the entire canal system
an appropriately sized spreader would be used to com- than lateral condensation with standard gutta-percha.
pact the cones into the softened mass. The use of warm Both techniques demonstrated acceptable root canal
injected gutta-percha by Obtura (Obtura/ Spartan, fillings in the apical one-third of the canal. Similar
USA) is also an accepted technique to add sufficient excellent adaptation was observed when comparing
bulk to the obturating material. The gutta-percha ThermaFil with the System B technique.472 However,
reaches its final set in 2 to 4 minutes. the gutta-percha from the ThermaFil carrier did show a
greater propensity to extrude beyond the apex.469,472
THERMAFIL SAFETY Wolcott and coworkers, in an in vitro study at
Saw and Messer from Australia evaluated and com- Tennessee, found that the movement of ThermaFil
pared the root strains associated with the compaction gutta-percha and sealer into lateral canals was compa-
of gutta-percha delivered from the Obtura and rable to lateral compaction; however, the ThermaFil
ThermaFil with lateral compaction.467 The ThermaFil was more effective in the main canal.473 Weller et al. at
technique required only minimal compaction that was Georgia used a split-tooth model to assess gutta-percha
limited to the coronal end of the carrier. Therefore, adaptation using Obtura, three types of ThermaFil core
with this technique there was significantly less strain carriers, and lateral compaction.474 No root canal seal-
during delivery and compaction than there was with er was used. The best adaptation was with Obtura
the other tested techniques. obturations, followed by ThermaFil plastic, ThermaFil
An apical stop or definitive apical constriction must titanium, ThermaFil stainless steel, and lateral com-
be present to prevent movement of the gutta-percha paction. Of interest in this study was the lack of apical
and/or the plastic core from extending beyond the root extrusion noted with the ThermaFil obturations.
canal. Often, a small puff of sealer or gutta-percha will In assessing leakage patterns with the contemporary
be extruded.464 A US Army group found that ThermaFil technique, Gutmann and W. P. and E. M.
ThermaFil was more apt to extrude through a patent Saunders found initially no significant differences in
apical foramen than was Obtura, Ultrafil, or warm lat- leakage between the techniques.469 At 3 to 5 months,
eral compaction (Endotec). On the other hand, if a however, both techniques revealed apical microleakage.
dentin plug was present at the apical orifice, On the other hand, ThermaFil obturations demon-
ThermaFil was less apt to extrude than were the oth- strated greater adaptation to the intricacies of the canal
system.469 Fabra-Campos reported much the same Silver Point Technique. Another solid-core mate-
from Spain.475 Using plastic-carrier ThermaFil and lat- rial of long standing (but not in good standing) is the
eral compaction, Pathomvanich and Edmunds from silver point technique. Despite nearly universal disap-
Wales used four different leakage methods and found probation, there are uses for silver points.
no difference in the leakage patterns with any of the The fault lies not in the point but in the execution.
evaluative techniques, nor was there any difference The cavity prepared to receive the point must be as
between lateral compaction and ThermaFil.476 Valli perfectly rounded and tapered as the point itself. It
and coworkers compared Densfil (Thermafil look-a- must fit like a cork in a bottle. Too often, round silver
like) obturations with lateral compaction in canals that points are cemented into ovoid canals. Over the years,
were prepared with hand instruments.477 While the as the sealer surrounding the point gradually dissolves
Densfil obturations showed less mean apical leakage away, microleakage and a subsequent periradicular
(1.39 mm) than lateral compaction (2.76 mm), the lesion develop.
data were not significant. Similarily, they also com- With all of the other techniques available, why use
pared the coronal leakage with both techniques, with silver points at all? They are very easy to use in narrow
the mean coronal leakage for Densfil being 2.87 mm canals. They are rigid, yet flexible, and can be posi-
and the mean coronal leakage for the lateral com- tioned rapidly. Ingle has pointed out that When
paction being 4.028 mm, but no statistically significant properly cemented to place, they provide a perfectly
differences were noted. adequate filling for the geriatric patient at a real time
Most recently, both short- and long-term leakage saving.478 He further noted that the very elderly have a
comparing ThermaFil with System B in the absence of limited life expectancy, and that silver points, even
the smear layer was reported by Kytridou et al.472 There improperly done, have been known to last over 20
were no significant differences in the short-term leak- years. Treatment for a 75-year-old patient may be
age patterns (10 and 24 days); however, leakage at 67 somewhat different than that for a 25-year-old patient.
days was greater in the ThermaFil group. Unlike other Furthermore, secondary dentin formation narrows
studies, however, these specimens were stored in Hanks the canal lumen in ancient teeth, lending them to
Balanced Salt Solution to better simulate the periradic- preparation by reaming. Good candidates would be
ular tissue fluid environment. the straight round canals in upper central incisors, or
the two canals in upper first premolars, or a straight SimpliFill was originally developed by Senia at
palatal canal in an upper first molar, or a straight distal Lightspeed Technology to complement the canal shape
canal of a lower first molar. Occasionally, even buccal created using Lightspeed instruments. The Apical GP
canals in upper molars, upper canines, or mesial canals Plug size is the same ISO size as the Lightspeed Master
in lower molars qualify if they are straight.478 Apical Rotary (MAR) (see Chapter 10).
These might well be cases in which the final apical prepa- Following the completion of canal preparation using
ration can best be done with one of the new reamer-type rotary Lightspeed, the specially designed Apical GP
instruments: the Handy-Gates (Dentsply/Maillefer; Tulsa, Plug Carrier corresponding to the MAR is trial fitted
Okla. and Switzerland) or the LightSpeed (LightSpeed without sealer into the dry canal. Before insertion,
Tech., Inc.; San Antonio, Tex.). In any event,the silver point however, the rubber stopper on the carrier, with its
baby need not be thrown out with the bath. attached gutta-percha, is set 2 mm short of the working
length. The carrier is then inserted into the canal and
APICAL THIRD FILLING slowly advanced, until it should start to bind at the
SimpliFill Obturation Technique length indicated by the rubber stop (ie, 2 mm short of
SimpliFill is a relatively new, two-phased obturation the working length). Once the fit has been verified, the
method that advocates the use of a stainless steel carri- Apical Plug carrier is removed and the canal is coated
er to place and compact a 5 mm segment of gutta-per- with an appropriate sealer using the MAR or a sealer
cha into the apical portion of a canal (Figure 11-83). saturated paper point. The rubber stopper on the carri-
Once placed, the carrier is removed, leaving a plug of er is now advanced 2 mm to the working length. The
gutta-percha. If a post is not desired, the second phase GP Plug is subsequently coated with sealer, inserted in
uses a specially designed syringe to backfill the remain- the canal, and advanced until resistance is felt, about 2
der of the canal with Ketac-Endo sealer along with mm short of the working length. Using the carrier, the
accessory cones of gutta-percha. The clinician can also GP Plug is now vertically compacted to the working
choose any other method to backfill the remaining por- length with firm apical pressure. The carrier must not
tion of the canal. According to the manufacturer, the be rotated during insertion or compaction. Once the
overall advantages of SimpliFill are that its use helps GP Plug is snugly fit, the GP Plug is released by rotat-
conserves dentin because of the Lightspeed instrumen- ing the carrier handle counterclockwise. During this
tation technique (less flaring); it eliminates additional rotation, the carrier must not be pushed or pulled. If
internal forces since no spreader or plugger is used to the GP Plug does not release, the carrier sleeve is
compact the apical plug; it is simple to master; and, in grasped with cotton pliers and, while pushing apically
contrast to other core-carrier systems, no carrier is left on the sleeve, the handle of the carrier is rotated coun-
in the canal. terclockwise and withdrawn.
Phase two consists of backfilling the remaining canal
if no post is desired. The clinician has a number of
options for backfilling, including the method advocat-
ed by the manufacturer described as follows. A
SimpliFill syringe is loaded with a sealer such as Ketac-
Endo and the sealer is slowly injected into the canal
space as the tip of the needle, equivalent to size #40 file,
contacts the GP Plug and is slowly withdrawn.
Inserting the needle all the way to the top of the plug
will help eliminate formation of air bubbles during the
backfill. An ISO standardized gutta-percha cone, equiv-
alent in size to the Apical GP Plug used to fill the apical
segment, is then coated with sealer and placed into the
sealer-filled canal until it contacts the compacted GP
Plug. Accessory gutta-percha cones can be added as
space fillers. As stated earlier, the clinician can also
backfill using traditional warm-vertical compaction or
Figure 11-83 SimpliFill apical gutta-percha plug. Point is lightly may simply backfill using the Obtura II.
heated and used as primary apical fill. Carrier is twisted for removal Since the technique is so new, there was only one
and used as plugger. (Courtesy of LightSpeed Technol.) published study. In 1999, Santos and coworkers at the
University of Texas at San Antonio evaluated the proto- this deliberately constitutes the new technique, a
type sectional method (SimpliFill) and compared it to biologic seal rather than a mechanochemical seal.
laterally compacted gutta-percha.479 In their study, sin- The premise that dentin filings will stimulate osteo
gle canal teeth were prepared using Lightspeed and or cementogenesis is well founded. Gottlieb and Orban
were subsequently obturated using three methods: lat- noted cementum forming around dentin chips in the
eral gutta-percho compaction with Ketac-Endo sealer, PDL as early as 1921. The German literature is replete
lateral compaction with Roths 801 sealer, or the with this method. Mayer and Ketterl filled 1,300 canals
SimpliFill sectional method with Ketac-Endo sealer fol- with apical dentin chips and reported 91% success.481
lowed by a single cone of gutta-percha in Ketac-Endo Ketterl later reported 95% success with cementum-like
sealer as backfill. Using India ink to measure leakage, closure at the apex.482 Waechter and Pritz also reported
they found no statistically significant difference in api- osteocementum apical closing in 20 human cases.483
cal microleakage among the three groups. In addition, Baume et al. described osteodentin closings but
it was noted that the sectional method was significant- incomplete calcification across all of their histologic
ly faster than lateral compaction.479 Although the tech- serial sections.484
nique appears promising, further studies will be neces- More often than not, dentin chip obturation undoubt-
sary along with clinical trials to determine the long- edly prevents overfilling. El Deeb et al. found exactly that:
term efficacy of the SimpliFill system. The presence of the apical dentinal plug, they stated,
Dentin Chip Apical Filling. A method finding was significantly effective in confining the irrigating
increasing favor, and one that inadvertently happens solutions and filling materials to the canal space.485
more often than not, is the apical dentin chip plug, This same conclusion was reached by Oswald et al.,
against which other materials are then compacted. who observed that dentin chips lead to quicker healing,
Quite probably, some of the so-called miraculous minimal inflammation, and apical cementum deposi-
cures occur apically, to prepared but unfilled canals, tion, even when the apex is perforated486 (Figure 11-
because the apical foramens have actually been obtu- 84). Holland et al., from Sao Paulo, found, however,
rated by dentin chips from the preparation.480 To do that dentin chips, if infected, are a serious deterrent to
Figure 11-84 Dentin chip root canal plug after 3 months. Left, Periradicular area. B, bone, C, cementum, DP, dentin plug. Arrows indicate
canal wall. Right, High-power view of same periradicular area. C, cementum within canal around dentin chips (arrows). OB, new bone cells.
Reproduced with permission from Oswald RJ and Friedman CE.486
A B
Figure 11-88 Periradicular repair following intracanal application of calcium hydroxide. A, Low-power view of periapex. Acute inflammatory
resorption of dentin and cementum following pulpectomy. Canal filled with calcium hydroxide mixture (CH). New hard tissue forming across
apex in response to Ca(OH)2. B, Higher-power view of repair leading to apical cap (arrow). (Courtesy of Dr. Billie Gail Jeansonne.)
the dentin walls, disinfecting the space, and totally filling As noted previously, calcium hydroxide resorbs away
the canal with calcium hydroxide, will practically ensure from the apex faster than do dentin chips.496 However,
apexification (Figure 11-89). The same phenomenon Pissiotis and Spngberg noted that calcium hydroxide
applies to the closed apexcementification reacting to mixed with saline resorbed but was replaced by bone in
the placement of a plug of calcium hydroxide. This is mandible implant studies.508
also the theory behind the calcium hydroxidecontain- Method of Use. Calcium hydroxide can be placed
ing sealers that appear to be better in theory than in as an apical plug in either a dry or moist state. Dry cal-
practice.507 cium hydroxide powder may be deposited in the coro-
A B
C D
Figure 11-89 Apexification of pulpless incisor with periradicular lesion. A, Preoperative film. B, Calcium hydroxide and camphorated
monochlorophenol filling canal and extruding through apex. C, Nine months later, canal filled with sealer, softened gutta-percha, and heavy
vertical compaction. No overfilling. D, Two-year recall. (Courtesy of Dr. Raymond G. Luebke.)
nal orifice from a sterilized amalgam carrier. The bolus INJECTION OR SPIRAL OBTURATION
may then be forced apically with a premeasured plug- By all accounts, filling the entire root canal by injection,
ger and tapped to place with the last size apical file that or pumping, or spiraling material into place has great
was used. One to 2 mm must be well condensed to appeal. Unfortunately, the methods fall short, either
block the foramen. Blockage should be tested with a file because the technique is inappropriate or the materials
that is one size smaller. used are inadequate.
Moist calcium hydroxide can be placed in a number Already discussed are the deficiencies encountered
of ways: as described earlier with amalgam carrier and when warm gutta-percha is injected from one of the
plugger, with a Lentulo spiral, or by injection from one syringes to fill the entire canal. These inadequacies are
of the commercial syringes loaded with calcium caused by shrinkage from the heated to the cooled
hydroxide: Calasept (J.S. Dental Prod., Sweden/USA) state, by failure to compact and eliminate voids, or by
or TempCanal (Pulpdent Corp.; Boston Mass.). In the extrusionserious overfilling.
latter method, the calcium hydroxide paste is deposited An earlier favorite method of filling the canal with
directly at the apical foramen from a 27-gauge needle chloropercha and pumping it into place with
and is then tamped to place with a premeasured plug- gutta-percha points failed because of the severe shrink-
ger. If some escapes, no great damage occurs. Because age from chloroform evaporation.383 This method was
of time constraints in military dentistry, a US Air Force followed by totally filling the canal with injected ZOE
group recommended compacting a plug of dry calcium cement, which will provide an immediate seal, but is
hydroxide powder at the open apex and immediately often subject to dissolution and leakage over the years,
placing the final root canal filling.509 leading to eventual failure.
In a comparison of techniques for filling entire small Fogel tested five sealers placed in canals with a pres-
curved canals with calcium hydroxide, the University of sure syringe. After 30 days, he found that AH-26, Cavit,
North Carolina group found the Lentulo spiral the Durelon, and ZOE cement all exhibited microleakage,
most effective, followed by the injection system. although AH-26 had the least marginal leakage and was
Counterclockwise rotation of a No. 25 file was the least the easiest to manage.513
effective.510 If the calcium hydroxide deposit is thick The fate of totally obturating canals with cements
enough and well condensed, it should serve not only as alone using a Lentulo spiral was sealed when a number
a stimulant to cemental growth but also as a barrier to of disasters of gross overfilling with N2 or RC2B were
extrusion of well-compacted gutta-percha obturation. reported. The material itself could hardly be blamed,
Efficacy of Calcium Hydroxide Apical Obturation. even though it is quite toxic. Rather, the blame falls on
The University of Washington group reported good the dentist misusing the device in a spinning handpiece
results with calcium hydroxide plugs. Both calcium (Figure 11-90). The Lentulo spiral will also cause
hydroxide and dentin chips worked equally well con- underfilling if not carefully monitored (Figure 11-91).
trolling extrusion of filling materials. Although One possible exception to the dangers and foibles of
both plugs resulted in significant calcification at the injecting filling material into the root canal may lie
foramenthe dentin plugs were complete No sig- with the emerging hydroxyapatite as an obturant. In
nificant difference in periradicular inflammation was this case, the calcium phosphate powders are mixed
noted.496 However, Holland noted persisting chronic with glycerine and the paste is injected into the canal.
inflammation and a wide variance in hard tissue depo- The moisture left in the canal and the apical moisture
sition.495 One would suspect contamination by oral cause the paste to set to hydroxyapatite. If the material
bacteria compromised his results. is extruded, it resorbs and will be replaced by bone.
A University of Alabama group tested for microleak- Admittedly, neither the technique nor the product have
age canals filled by lateral compaction but blocked at been thoroughly researched to date.137,138,163,164
the apex with three forms of calcium hydroxide: calci-
um hydroxide-USP, Calasept, or Vitapex (DiaDent DOWEL OR POST PREPARATION:
Group International; Burnaby, B.C., Canada). There POSSIBLE LEAKAGE
was no significant difference in leakage among the Once again, what comes out of the canal may be more
three forms of calcium hydroxide.511 Weisenseel et al. important than what goes in. In this case, it is the
confirmed much the same, stating that teeth with removal of a coronal portion of the root canal filling to
apical plugs of calcium hydroxide demonstrated signif- accommodate post or dowel placements.
icantly less leakage than teeth without apical plugs. All
were filled with laterally compacted gutta-percha.512
A B
Figure 11-90 Gross negligence in canal instrumentation and obturation. A, Apical perforation into maxillary sinus. B, Gross overfilling by
syringe leads to chronic sinusitis. Dentist was found guilty of negligence.
in microleakage when they removed all but 4 mm of radiolucencies found that 15% of the failure cases had
laterally condensed gutta-percha and sealer with four posts in place. The important findings, however, were
different methods of removal: a flame-heated the relationships to the length of the remaining apical
endodontic plugger, an electrically heated Touch n plug and the ineffective cemented seal of the post. A
Heat spreader, Peeso reamers, and GPX burs.516 GPX significantly higher percentage of failures was related
burs (Brasseler; Savannah, Ga.) are designed specifical- to apical fillings under 3 mm (Figure 11-93), and 24%
ly to remove gutta-percha and will not engage the of the posts with improper cement seal were associated
dentin walls (Figure 11-92). Others have evaluated the with periradicular radiolucencies.521
efficacy of the methods used in filling canals prior to
post preparation. In a Belgian leakage study, REMOVAL OF DEFECTIVE ROOT CANAL
researchers found no significant difference between FILLINGS AND OBJECTS AND RE-TREATMENT
obturation techniques: silver points, lateral com- Endodontists have long complained that their specialty
paction, warm/vertical compaction, Ultrafil injected, or has regressed from primary care into re-treatodontics.
Obtura technique.517 Many specialists note that 30 to 50% of their practice is
At Loma Linda University, lateral and vertical obtu- re-treatment. That includes having to take over a par-
ration was followed by gutta-percha removal with hot tially treated case, or worse yet, having to remove defec-
pluggers down to 5 to 6 mm from the apex. Coronal tive root canal fillings and entirely redo the treatment.
leakage studies in these specimens were then compared Chenail and Teplitsky reviewed the iatral as well as
with Thermafil obturation in which the metal-core car- patient-placed objects that block root canals. Among
rier was notched 5 to 6 mm from the tip and then twist- the iatral obstructions, they listed paper points, burs,
ed off after the obturator was fully into place. The api- files, glass beads, amalgam, and gold filings (and, one
cal plugs in the Thermafil group had the highest degree might add, plugger and spreader tips, and of course
of coronal dye penetration. The reason behind a coro- gutta-percha, cements and sealers, broaches, silver
nal leakage study was based on the fact that cemented points, and posts). Among the objects placed by
posts have an inherently weak seal and that oral fluids patients in teeth left open to drain, they listed nails,
(with bacteria) penetrate apically alongside the post pencil lead, toothpicks, tomato seeds, hatpins, needles,
and may reach the periapex if the apical gutta-percha pins, and other metal objects.522 Numerous methods
plug fails.518 and devices have been developed to retrieve and
Saunders et al. found in apical leakage studies that remove these obstructions.
when Thermafil plastic core carriers were used, the seal Gutta-percha and Sealer Removal. Compared
was not adversely affected by either immediate or with other filling materials, gutta-percha and sealer are
delayed post preparation.519 Mattison found little dif-
ference between Thermafil plastic and metal carri-
ers.520 A significant Swedish report of periradicular
relatively easy to remove. After the canal orifice of the tive filling and one or two drops of solvent are intro-
defective filling is uncovered, the adhesion of the duced from a syringe or the beaks of cotton pliers. The
gutta-percha is tested with a fine Hedstroem file. That reaming and filing actions are much improved as the
is, an attempt is made to pass the file alongside the fill- gutta-percha dissolves. One must be careful, however,
ing to the apical stop. If the filling is really defective, it not to pump the liquified mixture out through the api-
may be lifted out by blades of the file, or possibly, with cal foramen. Larger files are used high in the canal,
two fine files, one on either side of the gutta-percha. decreasing markedly in size toward the apex.523
If the gutta-percha is solid but the filling failed After the bulk of the old filling is removed, aggres-
because it is well short of the apex, a hot plugger may sive filing is done in an attempt to remove all of the
be repeatedly plunged into the mass, bringing out gutta-percha and sealer from the walls. Plaques of
gutta-percha each time. As much of the filling as possi- smear layer, debris, and bacteria must be uncovered to
ble should be removed by heat before instruments are ensure future success.
used to complete the job. Pieces of filling in the canal The solvents commonly used to liquefy gutta-percha
have been known to divert the file, and with persist- are chloroform, xylol, eucalyptol, and halothane.
ence, a perforation may be developed (Figure 11-94). Chloroform has been the favorite but fell into disfavor
Peeso reamers, Gates-Glidden drills, and round burs from a carcinogenic scare. Halothane was recommend-
should not be used because they are easily diverted. A ed as a substitute even though it is harder to obtain.
GPX gutta-percha remover is less dangerous in a With the lifting of the FDA ban on chloroform, fear of
low-speed handpiece because it coronally extrudes the it waned and it is still widely used.
frictionally heated gutta-percha without contacting the A number of studies evaluated solvents plus
dentin walls (see Figure 11-92). mechanical means of filling, namely, removal and rein-
Occasionally, gutta-percha solvents will need to be strumentation. Chloroform was used successfully in
used. Again, a well is made in the center of the defec- bypassing gutta-percha in well-sealed canals using a
Canal Finder System with K-files. The vertical stroke of
the Canal Finder handpiece served well to carry the
files to the apical stop in an average of 32 seconds in the
in vivo cases.524
Wilcox et al. found that no technique or solvent
removed all of the debris, although it appears that ini-
tially using heated pluggers, followed by chloroform
with ultrasonic instrumentation, had a slight edge.525
Wilcox later found canals were no cleaner when either
chloroform or sodium hypochlorite was used.526
Others have compared chloroform with other sol-
vents, and each time chloroform comes out ahead as the
most rapid and complete solvent.527531 Chloroform
dissolves gutta-percha nearly three times faster than
halothane.528 A US Navy group found halothane to be
an acceptable alternative to chloroform, particularly
when used with ultrasonic instrumentation.530 At
Creighton University, a group found both chloroform
and halothane effective in removing Thermafil
gutta-percha fillings with plastic cone carriers.531
Re-treatment Success Following Gutta-percha and
Sealer Removal. Bergenholtz et al. examined 660
teeth after re-treatment for failures and reported a 94%
success rate 2 years later. Of the cohort with periradic-
ular radiolucencies, however, 48% completely healed,
30% appeared to be healing, and 22% remained as fail-
Figure 11-94 Perforation (arrow) developed during attempt to ures.531 They later reported that, when teeth with peri-
remove old gutta-percha filling. Small pieces of gutta-percha will radicular lesions had overextensions during retreat-
divert endodontic instruments leading to perforation. ment, success was significantly reduced.532
Block and Langeland reported re-treatment of 50 Rowe has devised another technique using cyano-
endodontic failures that had been filled with N2. They acrylate glue (Permabond or Superglue #3) and hypo-
too stated that paste placed beyond the foramen dermic needles (A. H. R. Rowe, personal communica-
caused tissue damage and reduced prognosis.533 tion, 1981). From an assortment of different gauge nee-
Hard Paste Filling Removal. Gutta-percha and dles, one is selected that fits snugly, like a sleeve, over
soft sealer removal is one thing, but removing hard the protruding silver point. The bevel is removed,
pastes and cements such as N2, zinc phosphates, and blunting the needle, which is then cemented over the
silicates, that have no known solvents, is quite another. silver point. After 5 minutes of setting time, the needle
Krell and Neo reported the successful yet laborious is grasped with pliers or heavy hemostat and the silver
removal of hard pastes using a Cavi-Endo ultrasonic point worried from place (Figure 11-95, D). A varia-
unit.534 At the University of Minnesota, using an Enac tion of this method uses a larger-gauge needle and a
ultrasonic device with continuous water irrigation and small Hedstroem file. The piece of blunted needle is
a No. 30 file, they were able to remove hard paste fill- placed over the butt of the silver point. The file is then
ings in 3 minutes in one case and 10 minutes in anoth- inserted down the inside of the needle and wedged
er. The Enac unit vibrates at 30,000 Hz and had to be tightly into the space between (Figure 11-95, E).
operated at the full setting of 8 to be effective. The Another unique approach uses orthodontic ligature
Cavi-Endo vibrates at 25,000 Hz.535 wire and plastic tubing. First, a groove is cut around the
Silver Point, Post, and Obstruction Removal. The protruding butt end of the silver point with a half
removal of a cemented silver point is usually more diffi- round or wheel bur. The ligature wire is then doubled
cult than the removal of gutta-percha. If the point is bro- over, and the two free ends are passed through the tub-
ken off down in the canal, a method suggested by ing to form a loop at the end. The groove in the silver
Feldman536 in 1914 and modified by Glick (D. Glick, per- point is then lassoed with the wire loop (Figure 11-
sonal communication, February, 1965) may be used. Glick 95, F), which is cinched up tight with the plastic sleeve.
forces three fine Hedstroem files down alongside the point Adding a drop of cyanoacrylate cement may improve
as far as they will go (Figure 11-95, A). The three files are the grip. The tubing is tightly grasped with pliers or a
then twisted around one another, thus entangling the soft hemostat and the point is worked loose.537
silver point in a grip much like that exerted by a broach Acknowledging the source (see Figure 11-95, D),
holder (Figure 11-95, B). This method has also been com- Johnson and Beatty developed a commercial version of
pared with the grip exerted by the trick Mexican straw this tube/cyanoacrylate device. It may be used to
finger-cotthat becomes tighter the harder one pulls. The remove silver points, broken files, cemented posts, or
gradual pull on the files often loosens the silver point. This metal carriers of Thermafil.538 The EndoExtractor
procedure may be repeated a number of times, each time (Brasseler, USA) consists of tubular, trepan-end cutting
loosening the silver point a bit more. burs described by Masseram,539 along with a variety of
Getting down alongside the point to get a purchase sizes of tubes with handles attached. The
with the files may be difficult. Using a No. 1/2 round different-sized trepan burs fit over the point/post and
bur in a slow handpiece, removing sealer and dentin are used to cut a trench around it, thus freeing a few
but not nicking the point, is a start. After this, small millimeters of the point that may be grasped. An
files, chloroform, and/or EDTA may extend the dis- appropriate-sized hollow-tube extractor is chosen that
tance alongside the point to allow deeper penetration will snugly fit the extruding point.The extractor is then
with the very fine Hedstroem files. cemented to at least 2 mm of the point with cyano-
If the point has fortunately been left protruding into acrylate glue, and 5 minutes are allowed for it to set.
the pulp chamber, a sharp spoon excavator or curette The handle on the tube may then be used to twist and
also may be used to pry the point from its seat. A more lift the point from its seat. At the University of
efficient spoon excavator has been marketed by Stardent Minnesota, researchers have reported the successful use
with a triangular notch cut out in the tip of the blade. of the EndoExtractor to remove posts, silver points,
With this modification, the blade grips the silver from and broken files when all else failed.540
two sides rather than just by the curve of the blade, An improved version of the Endo Extractor
(Figure 11-95, C). Silver points may sometimes be (Roydent Dent. Prod., USA) uses the same principle,
grasped with an alligator ear forceps or an ophthalmic except that a Jacobs chuck, activated by a twist of the
suture holder (Castroviejo curved) (Hu-Friedy; handle, grasps the point/post, so that it may be pulled
Chicago, Ill.), broken loose from the cement by twisting, from the canal. Ruddle has also developed a post puller,
and removed. the Ruddle Instrument Removal System (IRS)
A B C
E F
Figure 11-95 Methods of removing silver points. A, Three fine Hedstroem files are worked down alongside silver point. B, By clockwise
motion, three files are twisted around each other, forming vise-like grip on soft silver that can then be dislodged. C, Special split-tongue
excavator used to pry point from place. D, Blunted hypodermic needle that fits tightly over silver point attached by cyanoacrylate. When
adhesive sets, needle is grasped with pliers or heavy hemostat. E, Loose-fitting blunted hypodermic needle is placed over silver point.
Hedstroem file is wedged alongside and used to worry point loose. F, Loop of orthodontic wire in plastic sleeve used to lasso groove cut
in silver point. Cyanoacrylate may be used to improve attachment.
(Dentsply/Tulsa Dental; Tulsa, Okla.), that trephines One must conclude that the ultrasonic and sonic
around the post by ultrasonics, then screws onto it and handpieces have added a whole new dimension to
levers the post from the canal. clearing obstructed canals, whether soft gutta-percha
Ultrasonic/Sonic Removal of Canal Obstructions. and sealer, hard setting cements, or metallic objects
The tightly fitted, well-cemented silver point that is that must be removed for re-treatment.
flush with the canal orifice is a challenge to remove.541
In these cases, and in the case of cemented posts, TEMPORARY CORONAL FILLING MATERIALS
removal is enhanced through the use of sonic or ultra- An unusual amount of research time and effort has
sonic devices. At the University of Iowa, researchers been expended in testing the efficacy of various inter-
placed a fine Hedstroem file down into the canal along- mediate coronal filling materials. At the outset, it is safe
side the defective silver point. The file was then enervat- to say that neither gutta-percha nor temporary stop-
ed by a Cavitron scaler and slowly withdrawn (Figure ping is presently used. Since those days, quickly placed,
11-96). A number of tries were usually necessary before yet apparently adequate, cements such as Cavit
the silver point loosened and could be retrieved. (Premier Dental, King of Prussia, Pa.) have dominated
At UCLA, Kuttler activated posts with a Cavitron the field.
scaler until the cement seal was broken and the post To properly select a temporary, one should know the
could be either extracted or unscrewed. criteria for selection.The role of these cements is to pre-
Deeper in the canal, the ultrasonic CaviEndo vent the root canal system from becoming contaminated
endodontic unit, mounted with a No. 15 file, can be during treatment by food debris, buccal fluids and
used to loosen obstructions and often float them microorganisms.543 Torabinejad et al. have pointed out
out.523 At the University of Saskatchewan, it was that, during or after treatment, root canals can be con-
reported that copious water irrigation was necessary taminated under several circumstances: (1) if the tem-
and that gentle up and down strokes were used until porary seal has broken down, (2) if the filling materials
the fragments floated out They removed not only and/or tooth structure have fractured or been lost, and
silver points and broken files, but spreader and bur tips (3) if the patient delays final restoration too long.544
as well. They warn that patience is needed.522 The properties that a good temporary material must
In Germany, the use of the Canal Finder System ver- possess have been well delineated by French
tical stroke handpiece retrieved 50% of the defective sil- researchers: good sealing to tooth structure against
ver points and fractured instruments. Alternate use of an marginal microleakage, lack of porosity, dimensional
ultrasonic activated file was also recommended.542 variations to hot and cold close to the tooth itself, good
abrasion and compression resistance, ease of insertion
and removal, compatibility with intracanal medica-
ments, and good esthetic appearance.543
This same French group has produced the definitive
study on the leading temporary cements presently on the
market: Cavit and IRM and TERM (Dentsply/Caulk,
USA). They note that Cavit is a premixed paste supplied
in collapsible tubes, that IRM is a ZOE cement rein-
forced by a polymethylemethacrylate resin, and that
TERM is a light-cure composite (urethane dimethacry-
late polymer resin).543
Others have learned that Cavit can cause discomfort
in vital teeth, probably through dessication. Also, it is a
moisture-initiated, autopolymerizing premixed calci-
um sulfate polyvinyl chloride acetate cement, and it
expands while setting.545 IRM must be mixed on a slab,
and thus porosity may be incorporated; TERM is
injected into the cavity and light cured for 40 seconds.
Figure 11-96 Removal of silver point flush with canal orifice
French researchers used bacteria in their microleak-
being removed with ultrasonic aid. Hedstroem file is placed along- age study because bacteria are the principal problem.
side point and ultrasonic scaler is activated as file is withdrawn. Streptococcus sanguis, an oral pathogen, is 500 times
Reproduced with permission from Krell KV et al.541 greater in size than blue aniline dye. Therefore, any
leakage indicates wide gaps or high porosity. The the glass ionomer Ketac Fil to be quite adequate if the
French group placed temporary fillings 4 mm thick and cavity is first acid etched. This rather time-consuming
tested leakage after 4 days of immersion in bacteria, approach gave a similar result to Kalzinol (Dentsply/
and then after thermocycling from 4 to 57C. DeTrey, Switzerland/USA), a reinforced ZOE cement.555
They found that Cavit and TERM did not allow bac- There are other factors that might affect the tempo-
teria to penetrate before or after thermocycling, whereas rary seal, one being the intracanal medicaments that
30% of the IRM fillings let S. sanguis pass before thermo- could dissolve and loosen the seal from below. Rutledge
cycling and 60% of the IRMs leaked after thermocycling. and Montgomery found, however, that neither
They believe that IRM was leaking through the filling eugenol, formocresol, nor CMCP broke the seal of
material itself because of mixing porosity, as well as mar- TERM, although the walking bleach paste of sodium
ginally.543 There is no question that, for short-duration, perborate and superoxol did so.573 Another group sug-
intermediate fillings, Cavit and TERM are preferred. gested that a pellet of cotton soaked in a medicament
Seven years later, the French group again tested the (CMCP) would act as a barrier if bacteria leaked
efficacy of Cavit, IRM, TERM, and a new adhesive, through the temporary filling.574
Fermit (Vivadent, France/USA), via leakage studies.546 Does a filling already in place that is penetrated by the
They concluded that Cavit was more leakproof than access cavity have any effect on microleakage? The answer
the other cements at day 2and at day 7. Cement is yes on two counts. First, the filling itself may be faulty
thickness averaged 4.1 mm.546 and leaking, and second, the temporary filling-in-the-fill-
In Taiwan, a new temporary material, Caviton (G-C ing may not adhere, and leakage will ensue.
Dental, Japan/USA), was tested against Cavit and IRM. If one suspects that the filling to be perforated for
The Chinese reported that Caviton provided the best access is already faulty, it should be totally removed.560
seal, followed by Cavit. IRM was a poor last.547 If this happens, a temporary filling will have to with-
Others have tested these materials (Cavit, IRM, and stand the trauma and abuse suffered by a two- or three-
TERM) and other temporary cements as well. The surface filling. In this event, a temporary material must
results are confusing, probably because of the indicator be chosen to withstand these stresses. At the University
dyes used, the significant temperature changes,548550 of Georgia, researchers determined that TERM
the stresses of mastication,551 the softening effect of restorations provided excellent seals and were statisti-
medicaments,552,553 and the length of time the fillings cally superior to Cavit and IRM for restoring complex
withstand the variables.554 endodontic access preparations. IRM leaked immedi-
Some found that Cavit must be at least 3.5 mm ately from thermal stress. Cavit has a setting expan-
thick,554 and that one should not plan an intervisit sion of 14%, so that it literally grew right out of Class
period for longer than 1 week.553,555 Most found Cavit, II cavities and severely cracked. Its low compressive
Cavit-G, and Cavit-W (hardness variations) as good as, strength and high solubility made it unacceptable for
if not the best of, the temporaries.543,555563, 567 Others long-term use.564
found Cavit less adequate than IRM and ZOE At the University of Georgia, workers prepared
cements.550,551,564,568570 endodontic access cavities in Class I amalgam fillings
Many studies agreed with the Deveaux group in Lille, and then restored the access cavities with various tem-
France, that TERM was superior or equal to all of the porary materials. Glass ionomer, TERM, Cavit-G, and
other temporary coronal sealants.543,558,561564,571 At IRM all provided excellent seals for up to 2 weeks,
the Universities of Iowa, Saskatchewan, and California, whereas zinc phosphate and polycarboxylate cements
workers disagreed with the value of TERM as a proved inadequate. No thermocycling was done. It
sealant.556,559,560 Most others also agreed with Deveaux tends to break the seal of all of these materials placed in
that the use of IRM is ill-advised, and that it leaks badly amalgam cavities.565
before and after thermocycling.543,558,559,562564 At Indiana University, they tested ZOE and Cavit in
More recently, a Berlin group found it efficacious to cavities prepared in amalgam and composite. They found
add glass-ionomer cement to temporary replace- that ZOE seals against marginal leakage better than Cavit
ments.572 They reported that only glass-ionomer when the access opening is placed through composite
cement and IRM combined with glass-ionomer cement resin, and that Cavit seals better than ZOE when the access
may prevent bacterial penetration to the periapex of opening is placed through amalgam. Thermocycling
root filled teeth over a 1 month period.572 apparently broke the bond with amalgam.566
Some research groups found zinc phosphate and Torabinejad et al. pointed out the importance of the
polycarboxylate cements most inadequate,562,563 but temporary seal lasting even after root canal therapy is
completed, emphasizing the importance of early final under full crowns.579583 One must assume that, along
restoration of the tooth. It took only 19 days for these pathways, bacteria could reach the pulp space
Staphylococcus placed in the crown to reach the apex in occupied by root canal fillings and then down the root
50% of the test cases and 42 days for 50% of the Proteus canal filling to the apex.544 None of the current luting
samples to do the same.544 The Torabinejad team later agents routinely prevent marginal leakage of cast
reported that bacteria in natural saliva will contami- restorations.582 Furthermore, all crowns leaked
nate root canals obturated by either lateral or vertical gingivally regardless of the type of crown margin
compaction, from crown to apex, in just 30 days if left preparation.583
open to the saliva.575 Therefore, it goes without saying that so-called per-
At Temple University, it was found that bacterial manent restorations of endodontic access cavities suf-
endotoxin could penetrate the full length of an obturat- fer microleakage as well. At the University of Iowa,
ed canal in just 20 days.576 More recently, the Iowa group Wilcox and Diaz-Arnold restored lingual access cavities
found that endotoxin, a potent inflammatory agent, with either Ketac-Fil glass ionomer cement or
may be able to penetrate obturating materials faster than Herculite composite resin (Sybron Endo/Kerr Dental
bacteria.577 They also extended the caveat: the need for Orange, Calif.). Acid etch was used as well as GLUMA
an immediate and proper coronal restoration after root dentin-bonding agent. After thermocycling, all of the
canal treatment is therefore reinforced.577 specimens leaked and they leaked right past the zinc
One must conclude from this full discussion that phosphate and/or temporary-stopping bases under-
temporary fillings are most important in multiple- neath. One specimen even leaked all the way to the api-
appointment treatment to prevent recontamination cal foramen.578
between appointments and, further, that the material A series of experiments at the University of Iowa
must be tough enough to withstand mastication. found that coronal microleakage, in the presence of
Between-appointment intervals should not exceed 1 saliva, was inevitable up to 85% of the time.584 At
week, and the temporaries must be thick enough to Indiana University, researchers also noted the penetrat-
prevent leakage. Finally, long-term temporization is ing effect of saliva and recommended re-treatment of
inadvisable. obturated root canals that have been exposed to the
TERM and glass-ionomer cement appear to be the oral cavity for at least 3 months.585
most acceptable temporaries, followed by Cavit in Class To confirm in vivo the penetrating effects of saliva
I cavities. ZOE, zinc phosphate, polycarboxylate from leaking coronal restorations seen in vitro,586 the
cements, and IRM, per se, are much less acceptable, and, Iowa group did coronal microleakage studies on mon-
of course, temporary stopping is totally unacceptable. keys. They reported dye penetration down the filled
root canals no matter which sealer was used: Sealapex,
FINAL CORONAL RESTORATION: AH-26, or ZOE.587
MICROLEAKAGE Undoubtedly, one of the causes of microleakage
It might be that as many root canal fillings fail because under cemented restorations relates to the dissolution
of bacterial entry from leaking coronal restorations as of the cement. Phillips et al., in a human in vivo study,
fail from periradicular leakage. As stated earlier, found that zinc phosphate cement was much more
Torabinejad et al. demonstrated an inordinate (50%) likely to disintegrate than were polycarboxylate or glass
bacterial contamination from the crown clear through ionomer cements.588 This is particularly important
to the apex, around and through well-compacted because zinc phosphate is still the most widely used lut-
gutta-percha fillings.544 ing agent.
After bacteria pass permanent occlusal fillings, there If all of these standard luting cements are faulty in
appears to be a clear track right past the bases placed their sealing ability, what is one to do to prevent
over the root canal fillingeither zinc phosphate microleakage? The answer appears to lie in the use of
cement or temporary stopping.578 the new adhesive resins, or glue that will adhere to all
Melton et al. recommended that leaking permanent tooth structures, as well as metals, other resins, and
restorations should be removed in their entirety porcelain.
before endodontic treatment560; it makes even more Tjan, Tan, and Li, at Loma Linda University, have
sense to remove any suspicious restorations after treat- shown that when the 4-META adhesive Amalgambond
ment as well, not try simply to restore the access cavity. (Parkell Dental, Farmingdale, N.Y.) is used to line both
There is a terrifying body of literature, for example, the prepared dentin and enamel, the newly placed
that testifies to microleakage all the way to the pulp amalgam filling is virtually leakproof (Figure 11-97, A).
In contrast, a cavity lined with Copalite allowed leakage Northwestern University revealed much the same
around the amalgam as far as the pulp589,590 (Figure resultsthe root canals that received an intraorifice
11-97, B). Amalgambond can also be used to bond new barrier leaked significantly less than the unsealed con-
amalgam to old amalgam, or composite to amalgam, trols, all of which leaked in < 49 days.592
gold, or other composite. Another 4-META product, At the University of Toronto a different approach
C & B Metabond (Parkell Dental, USA), will lute gold or was triedsealing the canals with two experimental
porcelain restorations to tooth without future leakage. glass-ionomer sealers, one containing an antimicrobial
Wilcox attempted to use GLUMA (Miles substance. The first sealer proved effective in prevent-
Laboratories, USA), the dentin-bonding agent, to ing the penetration of E. faecalis probably because of
adhere a composite resin to the tooth structure of the natural release of fluoride. The experimental sealer
endodontic access cavities in anterior teeth. After ther- with the added antibacterial needs more study.593
mocycling, it failed.578 Martin has recently introduced gutta-perch points
At this juncture, the solution to the problem of and an accompanying ZOE sealer, both of which con-
microleakage appears to be the resin-adhesive agents, tain iodoform, a well-known bacterial suppressant. In
particularly those that will adhere to more than just vitro results appear promising; however, long-term in
other resins, and possibly another approachplacing vivo efficacy has yet to be shown. The products are
an intraorifice barrier base, medicated or nonmedicat- marketed as MPG gutta-percha points and MCS root
ed, over the coronal root canal filling. canal sealer (Medidenta Products, Woodside, N.Y.).
At the University of Tennessee, the Himel group
placed pigmented glass-ionomer cements over the A NEW ENDODONTIC PARADIGM
coronal termination of the root canal filling. They It has been recognized for decades that the ideal end
reported that the teeth without an intraorifice barrier result of root canal therapy would be the closure of the
leaked significantly more than the teeth with the [glass- apical and all lateral foramina with reparative cemen-
ionomer] barriers (p < .05).591 Similar research at tum.594,595 This permits re-establishment of a complete
A B
Figure 11-97 Comparative study in microleakage between resin adhesive and copal varnish. A, Amalgam filling bonded to dentin (D) and
cementum (arrow) with Amalgambond and no microleakage. B, Amalgam filling lined with Copalite. Gross microleakage at gingival floor
(arrows) as well as from upper margin (curved arrow). (Courtesy of Drs. A. H. L. Tjan and D. E. Tan.)
attachment apparatus and precludes future failure reported that the disintegration of Sealapex indicat-
caused by pulpoperidontal fluid exchange and retroin- ed that solubility may be the price for increased activi-
vasion of bacteria. ty.601 In other words, these sealers must dissolve to
Following well-executed treatment, wherein infec- release their calcium hydroxide. It then becomes a
tion and irritation are terminated, cementoblasts and question of which will happen firstcementification
periodontal ligament slowly resurface the damaged across the apex or leakage into the exposed canal with
root and even close minor foramina that no longer its attendant problems? Is there a substitute for calcium
contain neurovascular bundles. hydroxide that may have its stimulating effects but not
But well-obturated major foramina that present a sur- its drawbacks? The answer may be hydroxyapatite!
face of sealers and/or gutta-percha to the periradicular Calcium-Phosphate Cement Obturation. Years
tissue will not be closed over. Cementum will not grow ago, Nevins and his associates were using cross-linked
across mildly irritating sealer surfaces. This leaves these collagencalcium phosphate gels to induce hard tissue
foramina vulnerable to leakage as cement sealers dissolve formation.602 More recently, Harbert has suggested
away over the years. How can this dilemma be resolved? using tricalcium phosphate as an apical plug, much like
Cementification. In the last two editions of this dentin shavings and calcium hydroxide have been
text, Ingle and Luebke made a case for the wider use of used.603 Even more recently, calcium phosphate cement
calcium hydroxide as a stimulating and healing agent (CPC) has been suggested as a total root canal filling
(Figure 11-98). The same thought occurred to others material.138
to use calcium hydroxide in filling the canal as well as The ADA-Paffenbarger Dental Research Center at
an interappointment canal medicament.595597 the US National Institute of Standards and Technology
Today, these speculations have become a reality. has developed a simple mixture of calcium phosphates
Calcium hydroxide is frequently being used as an apical that sets to become hydroxyapatite.Two calcium
plug before total obturation.499526,598 Furthermore, phosphate compounds, one acidic and one basic, are
calcium hydroxide is being incorporated into root unique in that when mixed with water they set into a
canal sealers in such commercial products as CRCS and hardened masshydroxyapatitethe principal min-
Sealapex. Although the reviews have been mixed on eral in teeth and bones.137 Tetracalcium phosphate is
these latter products, there have been some favorable the basic constituent, and the acidic component is
reports, but not without unfavorable side effects from either dicalcium phosphate dihydrate or anhydrous
overfilling.105111,153160,599601 dicalcium phosphate. Water is neither a reactant nor
A Turkish group found hard tissue formation more an important product in the reaction, but merely a
pronounced after root filling with Sealapex than with vehicle for dissolution of the reactants.137 Setting time
calcium hydroxide600 However, a Tel Aviv group may be extended by adding glycerin to the mixture.
Using a mild phosphoric acid solution speeds the dis-
solution of the components. Even aliquots of blood
from a surgical site may be substituted for water.
The final set, calcium phosphate cement (CPC),
consists of nearly all crystalline material, and porosity
is in direct ratio to the amount of solvent (water) used.
It is as radiopaque as bone. It is nearly insoluble in
water and is insoluble in saliva and blood, but is readi-
ly soluble in strong acids, which may be considered in
the event it must be removed.137
In testing the sealing ability of CPC when used as a
root canal sealer-filler, the Paffenbarger group report-
ed that in most of the specimens there was no dye
penetration into the filler-canal wall interface
(Figure 11-99). The mean depth of penetration was
only 0.15 mm overall.
Glycerin was used in mixing the CPC to improve its
extrudability from a 19-gauge needle. A funnel-shaped
Figure 11-98 Calcification forming around nidus of calcium needle is being considered (L. C. Chow, personal com-
hydroxide in tissue (arrow). (Courtesy of Dr. Raymond G. Luebke.) munication, August 1992). As far as tissue response to
A B
Figure 11-99 Noticeable difference in density of interface between filling materials and dentin wall (D). A, Canal filled with gutta-percha
(GP) and Grossmans cement (GC). Note discrepancies in sealer interface. B, Canal filled with calcium phosphate cement (CPC-A). Dense
interface explains superiority in apical leakage pattern. Reproduced with permission from Sugawara A, et al. JOE 1990;16:162.
CPC is concerned, the calcium phosphate treated ani- immediately adjacent to the cement218 (Figures 11-100,
mals showed mild irritation after 1 month, but thereafter 11-101). Exhaustive tests of CPC by Chinese researchers
the adverse tissue reactions were minimal. New bone for- in Shanghai found that CPC had no toxicity and all tests
mation adjacent to the cement was also observed.137 In for mutagenicity and potential carcinogenicity of CPC
another study, 63% of the specimens showed no evi- extracts are negative. They also noted that the implant
dence of inflammatory response to the CPC.604 Still tightly joined with the surrounding bone.605
another study, done on monkeys, in which canals were Krell and Wefel also found that, as a sealer, CPC
deliberately overfilled, new bone formation developed adheres well to the canal wall.606 In marked contrast to
A B
Figure 11-100 Periradicular area 3 months after purposeful overfill of canal with calcium phosphate cement CPC. The CPC (C) is bordered
by slender new bone trabeculae (NB) at the periphery where foam histocytes (H) are frequently present (right). LB, lamellar bone. A, 75
original magnification. B, 300 original magnification. Reproduced with permission from Hong YC et al.218
A B
Figure 11-101 Periradicular area 6 months after CPC overfill. A, Numerous ossification nidi (arrowheads) extend in various directions to
communicate with one another. Surrounding calcium phosphate cement (C), better seen in B, high power (300 original magnification). LB,
lamellar bone. Reproduced with permission from Hong YC et al.218
CPC, leakage was observed in the gutta-percha/ZOE as well as True Bone Ceramics (TBC), the latter derived
controls138 (see Figure 11-99). And at the US Naval from the incineration of bovine bone.611 Initially, with
Dental School, CPC was used as an apical barrier to both products, multinucleate giant cells and bone
facilitate obturation much as dentin chips and calcium resorption appeared. Within 3 months, however, new
hydroxide have been used. The teeth receiving apical bone had formed and the apex had been closed com-
CPC barriers...had significantly less dye penetration pletely with new hard tissue.611
than teeth without apical barriers. They recommend- If a delivery system can be perfected for CPC, it
ed CPC as a replacement for calcium hydroxide in could well be the sealer/barrier/filler of future
apexification cases.607 endodontics. The Paffenbarger Center did find that
Japanese researchers have already marketed apatite their material provided better sealant qualities than did
sealers. Two of them, G-5 and G-6, were tested at ZOE and gutta-percha.165 The fact that hydroxyapatite
Indiana University against Super-EBA for biocompata- is a naturally occurring product, and that bone grows
bility.608 While finding Super-EBA and G-5 biocompat- into and eventually replaces extruded material, makes
able, the researchers found G-6 promoted moderate it very acceptable biologically.612 Moreover, it may
inflammation and foreign body giant cell response. In replace calcium hydroxide in treating open-apex cases
addition to CPC, both G-5 and G-6 contain radiopaci- and fractured roots.
fiers, potassium fluoride, and citric acid, except G-6 Another possibility of using hydroxyapatite relates
contained more of the latter.608 to the laser. A cross-linked collagen-hydroxyapatite
A Japanese group at Osaka tested another commer- mixture has been placed in the root canal and melted
cial apatite sealer, ARS (Apatite Root Sealer), and found to place with a laser beam through a fiber optic.
that it caused severe inflammatory reactions.609 In the To date, none of these uses of calcium phosphate
same test, the Osaka group added 2.5% chondroitin cements have been approved by the US Food and Drug
sulfate to CP cement (TMD-5) and reported that it Administration, although clinical trials have been
has excellent histocompatability and potential as a applied for. This long, slow, and costly process must be
root canal sealer.609 undertaken before the products can be released for use
An Italian company has added hydroxyapatite to by the profession. More recently, an experimental
ZOE sealer, Bioseal (Ogna Lab. Farma., Italy), much as material, mineral trioxide aggregate (MTA), has been
calcium hydroxide has been added to CRCS sealer. suggested as a root-end filling material.613 This may
Whereas Gambarini and Tagger reported that Bioseal also turn out to be a promising material for use as an
did not adversely affect the sealing properties of the orthograde filling of the apical end of the root canal
cement, its beneficial effects were not within the scope prior to filling the remainder of the canal with
of the study.610 gutta-percha. It is presently being used primarily as a
In an entirely different direction in the development retrofilling material.
of apical barrier materials, Japanese researchers have Adhesive Resins. Very little has been published on
tested the use of freeze-dried allogenic dentin powder the use of adhesives in filling root canals.126,130,131 It
stands to reason that adhesive resins could serve to seal 7. Antoniazzi JH, Mjor IA, Nygaard-stby B. Assessment of the
dentin walls after smear removal. If it can be made to sealing properties of root filling materials. Odontol Tidskr
1968;76:261.
adhere to other filling materials such as gutta-percha, 8. Zakariasen KL, Stadem PS. Microleakage associated with mod-
and if it can be made radiopaque without ruining its ified eucapercha and chloropercha root canal filling tech-
setting and adhesive qualities, one would think that niques. Int Endod J 1982;15:67.
adhesives may have a bright future in endodontics. 9. Keane KM, Harrington GW. The use of chloroform-softened
Amalgambond already has been used to seal amalgam gutta-percha master cone and its effect on the apical seal.
JOE 1984;10:57.
retrofillings against microleakage.
10. Holland, GR. Periradicular response to apical plugs of dentin
At the University of Minnesota, Zidan and El Deeb and calcium hydroxide in ferret canines. JOE 1984;10:71.
found that Scotchbond, which bonds chemically to cal- 11. El Deeb ME, Zucker KJ, Messer H. Apical leakage in relation to
cium, provided a significantly better seal than radiographic density of gutta-percha using different obtu-
Tubliseal.130,131 In Australia, Gee found that he could ration techniques. JOE 1985;11:25.
12. El Deeb ME. The sealing ability of injection-molded thermo-
only achieve a result comparable to lateral compaction
plasticized gutta-percha. JOE 1985;11:84.
with AH-26 as a sealer by falling back on a complex sys- 13. Kennedy WA, Walker WA III, Gough RW. Smear layer removal
tem involving GLUMA as a bonding agent, followed by effects on apical leakage. JOE 1986;12:21.
Concise composite, plus AH-26 and gutta-percha. 14. Kersten HW, et al. Thermomechanical compaction of
GLUMA and Concise alone gave a poor leakage result.614 gutta-percha. I. A comparison of several compaction pro-
This hardly speaks well for GLUMA or Concise. cedures. Int Endod J 1986;19:125. Also II. 1986;19:134.
15. Marshall FJ, Massler M. Sealing pulpless teeth evaluated with
Kanca has shown that certain bonding agents will radioisotopes. J Dent Med 1961;16:172.
not adhere to moist dentin. GLUMA is one of these, as 16. Yee FS, Lugassy AA, Peterson JN. Filling of the root canals with
well as Scotchbond II, Clearfil, Photobond, and Tenure. adhesive materials. JOE 1975;1:145.
Since it is almost impossible to totally dry a root canal, 17. Czonstkowsky M, Michanowicz A, Varques JA. Evaluation of
an adhesive must be selected that bonds to both wet an injection of thermoplasticized low-temperature
gutta-percha using radioactive isotopes. JOE 1985;11:71.
and dry dentin. Kanca recommended All Bond 2 (Bisco 18. Fuss Z, et al. Comparative sealing quality of gutta-percha fol-
Dental, USA),615 although Amalgambond and C & B lowing the use of the McSpadden compactor and the
Metabond are just as effective. engine plugger. JOE 1985;11:117.
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are a number of possible methods of obturating root 21. Delivanis PD, Chapman KA. Comparison and reliability of
canals that will be kinder and gentler. More laborato- techniques for measuring leakage and marginal penetra-
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579. Mondelli J, et al. Marginal microleakage in cemented complete 600. Sonat B, et al. Periradicular tissue reaction to root fillings with
crowns. J Prosthet Dent 1978;40:632. Sealapex. Int Endod J 1990;23:46.
580. Larsen TD, Jensen JR. Microleakage of composite resin and 601. Tagger M, Tagger E, et al. Release of calcium and hydroxyl ions
amalgam core material under complete cast core crowns. J from set endodontic sealers containing calcium hydroxide.
Prosthet Dent 1980;44:40. JOE 1988;14:588.
581. Tjan AHL, et al. The effect of thermal stress on the marginal 602. Nevins AJ, et al. Pulpotomy and partial pulpectomy proce-
seal of cast gold full crowns. J Am Dent Assoc 1980;100:48. dures in monkey teeth using cross-linked collagen-calcium
582. Kawamura RM, et al. Marginal seal of cast full crowns: an in phosphate gel. Oral Surg 1980;49:360.
vitro study. Gen Dent 1983;31:282. 603. Harbert H. Generic tricalcium phosphate plugs: an adjunct in
583. Goldman M, et al. Microleakagefull crowns and the dental endodontics. JOE 1991;17:131.
pulp. JOE 1992;18:473. 604. Chohayeb AA, Chow LC, et al. Evaluation of calcium phos-
584. Swanson K, Madison S. An evaluation of coronal microleakage phate as a root canal sealer-filler material. JOE 1987;13:384.
in endodontically treated teeth. Part I. Time periods. JOE 605. Changsheng L, Wang W, Shen W, et al. Evaluation of the bio-
1987;13:56. compatability of a nonceramic hydroxyapatite. JOE
585. Magura ME, et al. Human saliva coronal microleakage in 1997;23:490.
obturated root canals: an in vitro study. JOE 1991;17:324. 606. Krell KV, Wefel JS. Calcium phosphate cement root canal seal-
586. Madison S, Swanson K, et al. An evaluation of coronal erscanning electron microscopic examination. JOE
microleakage in endodontically treated teeth. Part II. Sealer 1984;10:571.
types. JOE 1987;13:109. 607. Goodell GG, Mork TO, Hutter JW, Nicoll BK. Linear dye pen-
587. Madison S, Wilcox LR. An evaluation of coronal microleakage etration of a calcium phosphate cement apical barrier. JOE
in endodontically treated teeth. Part III. In vivo study. JOE 1997;23:174.
1988;14:455. 608. Steinbrunner RL, Brown CE Jr, Legan JJ, Kafrawy AH.
588. Phillips RW, et al. In vivo disintegration of luting cements. J Biocompatability of two apatite cements. JOE 1998;24:325.
Am Dent Assoc 1987;114:339. 609. Yoshikawa M, Hayami S, Tsuji I, Toda T. Histopathological
589. Tjan AHL, Tan DE. Microleakage of combined amalgam/com- study of a newly developed root canal sealer containing
postie resin restorations with Amalgambond [abstract]. tetracalcium-dicalcium phosphates and 1.0% chondroitin
JDR 1992;71:210. sulfate. JOE 1997;23:162.
590. Tjan AHL, Li T. Microleakage of amalgam restorations lined 610. Gambarini G, Tagger M. Sealing ability of a new hydroxyap-
with Amalgambond or All-Bond liner [abstract]. JDR atite-containing sealer using lateral condensation and ther-
1991;71:660. matic compaction of gutta-percha, in vitro. JOE
591. Wolcott JF, Hicks ML, Himel VT. Evaluation of pigmented 1996;22:165.
intraorifice barriers in endodontically treated teeth. JOE 611. Yoshida T, Itoh T, Saitoh T, Sekine I. Hisopathological study of
1999;25:589. the use of freeze-dried allogenic dentin powder and tru
592. Pisano DM, DiFiore PM, McClanahan SB, et al. Intraorifice bone ceramic as apical barrier materials. JOE 1998;24:581.
sealing of gutta-percha obturated root canals to prevent 612. Friedman CD, et al. Hydroxyapatite cement. II. obliteration
coronal microleakage. JOE 1998;24:659. and reconstruction of the cat frontal sinus. Arch
593. McDougall IG, Patel V, Santerre P, Friedman S. Resistance of Otolaryngol Head Neck Surg 1991;117:385.
experimental glass ionomer sealers to bacterial penetration 613. Torabinejad M, Watson TF, Pitt Ford TR. Sealing ability of a
in vitro. JOE 1998;25:739. mineral trioxide aggregate when used as a root-end filling
594. Grove CJ. Natures method of making perfect root fillings fol- material. JOE 1993;19:591.
lowing pulp removal. Dent Cosmos 1921;63:969. 614. Gee JY. A comparison of five methods of root canal obturation
595. Coolidge ED, Kesel RG. Endodontology, 2nd ed. Philadelphia: by means of dye penetration. Aust Dent J 1987;32:279.
Lea & Febiger; 1956. 615. Kanca J III. Improving bond strength through acid etching of
596. Laws A. Calcium hydroxide as a possible root filling material. dentin and bonding to wet dentin surfaces. J Am Dent
N Z Dent J 1962;58:199. Assoc 1992;123:35.
Chapter 12
ENDODONTIC SURGERY
Steven G. Morrow and Richard A. Rubinstein
treatments is high, failures do occur. Many retrospective 12-1). Even though these indications describe specific
studies have established endodontic success rates, rang- situations, they should not be considered automatic
ing from a high of 96% to a low of 53%.613 indications but should be applied as judgment and cir-
Additionally, in recent years, there has been an increas- cumstances dictate.
ing interest in endodontic re-treatment procedures (see
chapter 13). Studies reporting the success rate for non- CONTRAINDICATIONS
surgical re-treatment indicate successes as low as 62% Few absolute contraindications to endodontic surgery
to as high as 98%.1418 This emphasis on nonsurgical exist. Most contraindications are relative, and they are
re-treatment of endodontic failures has probably had usually limited to three areas: (1) the patients medical
the single greatest impact on the indications for surgical status, (2) anatomic considerations, and (3) the den-
intervention in the treatment of endodontic pathosis. tists skills and experience.
A classic categorization of specific indications and Advances in medicine have dramatically increased
contraindications was developed by Luebke, Glick, and life expectancy and the survival rate from most of
Ingle and has been modified for this chapter19 (Table todays diseases. Dentists are, with increasing frequen-
B C
cy, being asked to treat medically compromised of all potential medical complications and a review of
patients. When considering performing any surgical the patients current drug regimen, a consultation with
procedure on a patient who reports a major systems the primary care physician or specialist may be in
disorder (cardiovascular, respiratory, digestive, hepatic, order. The dentist should explain to the physician the
renal, immune, or skeletomuscular), a thorough med- needed endodontic surgical treatment, including a
ical history is mandatory. Following the identification brief description of the procedure, anesthetic agents
surgeon with the needed armamentarium is usually decrease in the length of morbidity will follow the
able to circumvent these anatomic limitations and release of pressure and the evacuation of the by-prod-
accomplish successful endodontic surgery. ucts of inflammation and infection.21 Surgical drainage
It is imperative that dental professionals keep in may be accomplished by (1) incision and drainage (I &
mind that all treatment rendered by them to their D) of the soft tissue or (2) trephination of the alveolar
patients must be in the patients best interest and at the cortical plate.
highest quality possible. As a professional, one has an
obligation to know ones limitations of clinical skills Incision and Drainage
and to confine treatment efforts to be consistent with Fluctuant soft-tissue swelling occurs when periradicular
those limitations. Unless the general practitioner has inflammatory exudate exits through the medullary
had extensive surgical training and experience, the bone and the cortical plate. Once through the cortical
majority of endodontic surgical procedures should be plate, the exudate spreads into the surrounding soft tis-
done by trained endodontic specialists. When receiving sues. When this occurs, an incision should be made
care of a specialized nature, patients need and deserve through the focal point of the localized swelling to
treatment that meets the standard of care delivered by relieve pressure, eliminate exudate and toxins, and stim-
competent practitioners who are trained as special- ulate healing. If the swelling is intraoral and localized,
ists.19 The standard of care in dentistry is that practiced the infection may be managed by surgical drainage
by the specialist in any given dental discipline.20 alone. However, if the swelling is diffuse or has spread
into extraoral musculofascial tissues or spaces, surgical
CLASSIFICATION OF ENDODONTIC drainage should be supplemented with appropriate sys-
SURGICAL PROCEDURES temic antibiotic therapy.22 (Figure 12-5) (also see chap-
Endodontic surgery encompasses surgical procedures ter 18, Pharmacology for Endodontics).
performed to remove the causative agents of periradic- Learning the correct timing for I & D takes experi-
ular pathosis and to restore the periodontium to a state ence. The patient often presents with a generalized, dif-
of biologic and functional health. These procedures fuse facial swelling that is indurated. Caution should
may be classified as follows: always be exercised with hard swellings of this nature,
especially when accompanied by a fever. Such an infec-
1. Surgical drainage tion can extend into fascial planes and anatomic spaces
1. Incision and drainage (I & D) and become life threatening. Consultation with, or
2. Cortical trephination (fistulative surgery) referral to, an appropriate specialist may be indicated.
2. Periradicular surgery Unfortunately, incision into a diffuse or indurated
1. Curettage swelling before its localization is often unsuccessful in
2. Biopsy affording immediate relief or reduction of the swelling.
3. Root-end resection When this situation exists, it has been suggested that
4. Root-end preparation and filling the patient be placed on appropriate systemic antibiot-
5. Corrective surgery ic therapy and instructed to use hot salt water mouth
1. Perforation repair holds (1412 tsp of salt in a 1012-oz glass of hot water)
a. Mechanical (iatrogenic) in the swollen area to assist in the localization of the
b. Resorptive (internal and external) swelling to a more fluctuant state. The clinical situation
2. Root resection should be monitored every 24 hours. As soon as the
3. Hemisection swelling has localized and a fluctuant area has devel-
oped, surgical drainage should be performed.3
3. Replacement surgery (extraction/replantation)
Incision and Drainage Tray Setup. The tray setup
4. Implant surgery should be simple and uncluttered. The instruments
1. Endodontic implants and supplies needed for the procedure should be laid
2. Root-form osseointegrated implants out in the order of their use (Figure 12-6).
Local Anesthesia. Whenever possible, nerve block
SURGICAL DRAINAGE injection is the preferable method for obtaining local
Surgical drainage is indicated when purulent and/or anesthesia. In some cases, block injections must be sup-
hemorrhagic exudate forms within the soft tissue or plemented with local infiltration to obtain adequate
the alveolar bone as a result of a symptomatic peri- local anesthesia. In other clinical situations, block
radicular abscess. A significant reduction of pain and a injections are either impossible or impractical and
such as a No. 11 or No. 12, rather than a rounded No. 15 drainage through the root canal system (apical trephi-
blade. The exudate should be aspirated and, if indicated, nation) whenever possible. This may involve the
a sample collected for bacteriologic culturing. Probing removal of intraradicular posts and/or existing root
with a curette or hemostat into the incisional wound to canal obturation material. Apical trephination involves
release exudate entrapped in tissue compartments will penetration of the apical foramen with a small
facilitate a more effective result2 (Figure 12-7). endodontic file and enlarging the apical opening to a
Placement of a Drain. The use of drains following size No. 20 or No. 25 file to allow drainage from the
an I & D procedure is controversial. Frank et al. recom- periradicular lesion into the canal space. The decision
mended the use of a rubber dam drain to maintain the about whether to perform apical or cortical trephina-
patency of the surgical opening.3 McDonald and tion is based primarily on clinical judgment regarding
Hovland have stated that the incision alone will usual- the urgency of obtaining drainage.
ly provide the needed drainage.28 However, if initial Cortical trephination involves making an incision
drainage is limited, placement of a drain may be indi- through mucoperiosteal tissues and perforating
cated. The drain may be made of either iodoform gauze through the cortical plate with a rotary instrument
or rubber dam material cut in an H or Christmas (Figure 12-8). Some practitioners prefer to lay a
tree shape. It may be sutured in place for added reten- mucoperiosteal flap to expose the buccal/labial cortical
tion and should be removed after 2 to 3 days. Bellizzi plate before the trephination procedure. The objective is
and Loushine recommended the use of a 14-inch to create a pathway through the cancellous bone to the
Penrose drain, which should be sutured in place and vicinity of the involved periradicular tissues. It is often
removed in 24 to 48 hours.29 difficult to identify the appropriate site for cortical
Gutmann and Harrison stated that the use of drains trephination. Good quality diagnostic radiographs and
following I & D procedures has been greatly abused.2 careful clinical examination will aid in determining the
Patients with localized or diffuse intraoral swellings, appropriate trephination site. The site most often rec-
even if mild extraoral swelling is present, do not usual- ommended is at or near the root apex.3,3234 Gutmann
ly require drains following I & D procedures. Healing and Harrison2 suggest, however, that the trephination
will progress much more rapidly without insertion of site should be at or about midroot level in the interden-
an artificial barrier in the incisional wound site. The tal bone, either mesial or distal to the affected tooth.
tissues should be allowed to close the incisional wound Cortical trephination should always be initiated from a
at their normal wound-healing pace, which is about 24 buccal approach, never from the lingual or palatal.
to 48 hours. When sufficient drainage has occurred, Gutmann and Harrison recommend using either a No.
epithelial closure of the incisional wound will follow. 6 or No. 8 round bur in a high-speed handpiece to pen-
The insertion of a drain is only indicated in cases pre- etrate the cortical plate. A reamer or K-type file is then
senting with moderate to severe cellulitis and other passed through the cancellous bone into the vicinity of
positive signs of an aggressive infective process. the periradicular tissues. It is not necessary to pass the
instrument directly to the root apex to achieve effective
Cortical Trephination results.2 The clinician must exercise good judgment to
Cortical trephination is a procedure involving the per- avoid anatomic structures such as the maxillary sinus
foration of the cortical plate to accomplish the release and the neurovascular contents of the mandibular canal
of pressure from the accumulation of exudate within and the mental foramen, as well as the tooth itself.
the alveolar bone. This is a limited-use procedure and
is fraught with peril and potential negative complica- PERIRADICULAR SURGERY
tions. Patients who present with moderate to severe As previously discussed, the indications for, and the
pain but with no intraoral or extraoral swelling may application of, periradicular endodontic surgery have
require drainage of periradicular exudate to alleviate undergone dramatic changes in the last two decades.
the acute symptoms. Literature pertaining to this pro- These changes have been especially evident when deal-
cedure is very limited and consists primarily of case ing with the treatment of failed nonsurgical endodon-
reports, opinions, and clinical experiences.2 Two clini- tic treatments. A widely held principle of endodontic
cal studies have been reported on trephination proce- diagnosis and treatment planning is that the primary
dures. However, they were both designed to investigate modality for endodontic treatment failure should be
the efficacy of trephination in avoiding postobturation nonsurgical endodontic re-treatment whenever possi-
pain rather than in treating existing acute condi- ble2,3,28,3539 (see chapter 13, Outcome of Endodontic
tions.30,31 The treatment of choice for these patients is Treatment and Re-treatment).
A B
C D
E F
Figure 12-7 Incision and drainage of acute apical abscess. A, Good level of anesthesia is established and region is packed with gauze
sponges. B, Sweeping incision is made through core of lesion with No. 11 or 12 scalpel. Drainage is aspirated by assistant. C, Profile view of
incision showing scalpel carried through to bone. D, In some cases a small curved hemostat through defect of bony plate into body of infec-
tion. By spreading beaks, adequate drainage is established and may be maintained by suturing T-drain through incision. Patient requires
antibiotics for bacteremia and analgesics to control discomfort. E, T-drain is positioned to ensure patency of incision until all drainage ceas-
es. F, If drain will not remain in place, it may be sutured.
Figure 12-9 Suggested surgical instrument setup. Top Row: Extra 2-inch 2-inch gauze; irrigating syringe with sterile saline, (Monoject);
two extra carpules lidocaine 1/50,000 epinephrine; Teflon gauze cut in small squares; surgical length FG carbide burs No. 6, No. 8, and No.
H267 (Brassler); 4-0 Vicryl (Polyglactin 910) suture; needle holder; scissors. Bottom Row: Scalpel handle with No. 15C Bard-Parker blade;
mouth mirror, front surface No. 4; cow horn DE explorer; No. 16 DE endodontic explorer; periodontal probe; perio curettes; bone curettes;
Morse No. 00 scaler (Ransom and Randolph); periosteal elevators; flap retractors; locking cotton pliers; root-end filling material carrier; root-
end filling condenser; front surface micro mirrors. Instruments required for endodontic surgery are prearranged on the surgical tray with
logical placement in order of their use from left to right. Instruments are sterilized and packaged in readiness for use.
contamination and thereby reducing the inoculation of their ability to produce profound anesthesia but in the
microorganisms into the surgical wound. Chlorhexidine manner in which they are metabolized and the poten-
gluconate (Peridex) has been shown to decrease salivary tial for allergic reactions. Esters have a much higher
bacterial counts by 80 to 90% with a return to normal allergic potential than do amides.41 The only ester local
within 48 hours.40 Gutmann and Harrison recommend anesthetic available in dental cartridges in the United
that chlorhexidine gluconate oral rinses should be start- States is a combination of propoxycaine and procaine
ed the day before surgery, given immediately before sur- (Ravocaine).
gery, and continued for 4 to 5 days following surgery.2 The amide group of local anesthetics, which include
The reduction in numbers of oral bacteria before and lidocaine (Xylocaine), mepivacaine (Carbocaine),
during the early postsurgical period and the inhibition prilocaine (Citanest), bupivacaine (Marcaine), etido-
of plaque formation produce a markedly improved envi- caine (Duranest), and articaine (Ultracaine), undergo a
ronment for wound healing.2 complex metabolic breakdown in the liver. Patients
Most periradicular surgical procedures, regardless of with a known liver dysfunction should be adminis-
their indication, share a number of concepts and prin- tered amide local anesthetic agents with caution
ciples: (1) the need for profound local anesthesia and because of the potential for a high systemic blood con-
hemostasis, (2) management of soft tissues, (3) man- centration of the drug. Also, patients with severe renal
agement of hard tissues, (4) surgical access, both visual impairment may be unable to remove the anesthetic
and operative, (5) access to root structure, (6) peri- agent from the blood, which may result in an increased
radicular curettage, (7) root-end resection, (8) root- potential for toxicity as a result of elevated blood levels
end preparation, (9) root-end filling, (10) soft-tissue of the drug. Therefore, significant renal dysfunction
repositioning and suturing, and (11) postsurgical care. presents a relative contraindication, and dosage limits
All of these concepts and principles may not be used in should be lowered.23,41
any given surgery. However, an in-depth knowledge The high clinical success rate in producing profound
and understanding of these principles, and the manner and prolonged local anesthesia along with its low poten-
in which they relate to the biology and physiology of tial for allergic reactions makes lidocaine (Xylocaine)
the tissues involved, is of major importance. The strict the anesthetic agent of choice for periradicular surgery.
adherence to and application of these principles will Selection of another anesthetic agent is indicated only in
greatly influence the success of the surgical treatment the presence of a true documented contraindication. If
and will minimize patient morbidity. the use of an amide anesthetic agent (lidocaine) is
absolutely contraindicated, the ester agent, procaine-
Anesthesia and Hemostasis propoxycaine with levonordefrin (Ravocaine with Neo-
The injection of a local anesthetic agent that contains a Cobefrin), is the only choice at present.2
vasoconstrictor has two equally important objectives: Selection of Vasoconstrictor Agent. The choice of
(1) to obtain profound and prolonged anesthesia and (2) vasoconstrictor in the local anesthetic will have an
to provide good hemostasis both during and after the effect on both the duration of anesthesia and the qual-
surgical procedure. To sacrifice one for the other is ity of hemorrhage control at the surgical site.23,4244
shortsighted and unnecessary. Failure to obtain pro- Vasopressor agents used in dentistry are direct-acting,
found surgical anesthesia will result in needless pain and sympathomimetic (adrenergic) amines that exert their
anxiety for the patient. Inadequate hemostasis will result action by stimulating special receptors (alpha- and
in poor visibility of the surgical site, thus prolonging the beta-adrenergic receptors) on the smooth muscle cells
procedure and resulting in increased patient morbidity. in the microcirculation of various tissues. These agents
With the proper handling of any medical condition with include epinephrine (Adrenalin), levonordefrin (Neo-
which the patient may present, and the selection of an Cobefrin), and levarterenol (Levophed, noradrenaline,
appropriate anesthetic agent and vasoconstrictor, it is norepinephrine).41,42 For the purpose of hemostasis,
possible to accomplish both objectives. there is little or no justification for the use of
Selection of Anesthetic Agent. The selection of an levarterenol. The degree of hemostasis required for
appropriate anesthetic agent should always be based on most periradicular surgical procedures cannot be pro-
the medical status of the patient and the desired dura- duced safely by levarterenol.41
tion of anesthesia needed (see chapter 9, Preparation Ahlquist was the first to determine the existence of two
for Endodontic Treatment). The two major groups of types of adrenergic receptors.45 He termed them alpha
local anesthetic agents are the esters and amides. The and beta. He documented that each produces different
important difference between these groups lies not in responses when stimulated. Many tissues have both alpha
and beta receptors; however, one will usually predomi- some distance from the surgical site. Thus, the vasopres-
nate. Gage demonstrated that the action of a vasopressor sor agent in the anesthetic preparation used in nerve
drug on the microvasculature depends on (1) the pre- block anesthesia will not significantly affect the blood
dominant receptor type and (2) the receptor selectivity of flow at the surgical site. Profound nerve block anesthesia
the vasopressor drug.46 Alpha receptors predominate in can be achieved with a local anesthetic containing dilute
the oral mucosa and gingival tissues, whereas beta recep- (1:100,000 or 1:200,000) epinephrine.23,24
tors predominate in skeletal muscle.23,47 Epinephrine Hemostasis, unlike anesthesia, however, cannot be
receptor selectivity is approximately equal for alpha and achieved by injecting into distant sites.48 Only the small
beta receptors. Levonordefrin receptor selectivity, howev- vessels of the microvasculature are affected by the
er, is primarily for alpha-adrenergic receptors. injected vasopressor; larger vascular channels are not.
Stimulation of the alpha-adrenergic receptors will An inferior alveolar nerve block injection effectively
result in contraction of the smooth muscle cells in the blocks pain transmission from the surgical site; howev-
microvasculature with a subsequent reduction of blood er, the vasopressor injected has no effect on the inferi-
flow through the vascular bed. Stimulation of the beta- or alveolar artery and normal blood flow continues to
adrenergic receptors will result in a relaxation of the the peripheral surgical site. Therefore, additional injec-
smooth muscle cells in the microvasculature with a sub- tions must be administered in the soft tissue in the
sequent increased blood flow through the vascular bed. immediate area of the surgery. This is accomplished by
Since epinephrine receptor selectivity is equal for alpha local infiltration using a higher concentration
and beta receptors, and beta receptors predominate in (1:50,000 epinephrine) of vasopressor in the anesthetic
skeletal muscle, it is important not to inject epinephrine solution. In the maxilla, infiltration anesthesia can
into skeletal muscles in the area of endodontic surgery or simultaneously achieve anesthesia and hemostasis. It is
a vasodilation with increased blood flow will result.23,46 important to note that, whatever technique is used to
Epinephrine is the most effective and most widely obtain anesthesia, infiltration in the surgical site is
used vasoconstrictor agent used in dental anesthet- always required to obtain hemostasis. 2,57
ics.41,4850 The other vasopressors available are less The infiltration sites of injection for periradicular
effective. Even though they are used in higher concen- surgery are always multiple and involve deposition of
trations in an effort to compensate for their lower anesthetic throughout the entire surgical field in the
effectiveness, the difference in the degree of clinical alveolar mucosa just superficial to the periosteum at the
effect is readily observable. Many studies have been level of the root apices (Figure 12-10). Following block
reported measuring the plasma catecholamine levels anesthesia, using a 30-gauge needle with the bevel
and the clinical effects of the injection of epinephrine toward bone, a small amount of solution (0.250.50 mL)
containing local anesthetics for dental treatment.5155 should be slowly deposited. The needle tip is then moved
The results of these studies indicate that even though peripherally (mesially and distally) and similar small
the plasma level of catecholamines increases following amounts are slowly injected in adjacent areas.2,48
the injection, this increase does not generally appear to
be associated with any significant cardiovascular effects
in healthy patients or those with mild to moderate
heart disease. Pallasch stated that the hemodynamic
alterations seen with elevated plasma epinephrine are
usually quite short in duration, probably because of the
very short plasma half-life of epinephrine, usually less
than 1 minute. He also stated that the good achieved by
the inclusion of vasoconstrictors in dental local anes-
thetics greatly outweighs any potential deleterious
effects of these agents.56
Injection Sites and Technique. For periradicular
surgery, it is imperative that profound prolonged anes-
thesia and maximum hemostasis be achieved. In addi-
tion to the choice of anesthetic and vasopressor agents,
the sites and technique of injection are important factors Figure 12-10 Proper placement of needle for infiltration anesthesia
as well. Nerve block anesthesia involves injection in close to obtain maximum surgical hemostasis is in the alveolar mucosa just
proximity to a main nerve trunk that is usually located superficial to the periosteum at the level of the root apices.
The rate of injection in the target sites directly dures. Visual access enables the endodontic surgeon to
affects the degree of hemostasis.2 The recommended see the entire surgical field. Operative access allows the
injection rate is 1 mL/minute, with a maximum safe surgeon to perform the needed surgical procedure(s)
rate of 2 mL/minute.41,58 Rapid injection produces with the highest quality and in the shortest amount of
localized pooling of solution in the injected tissues, time. This will result in the least amount of surgical
resulting in delayed and limited diffusion into adjacent trauma and a reduction in postsurgical morbidity.
tissues. This results in minimal surface contact with the All surgical procedures require the intentional
microvascular bed and less than optimal hemostasis. wounding of specific tissues, and the subsequent
The amount of anesthetic solution needed varies wound healing depends on the type of tissues wound-
and depends on the size of the surgical site. In a small ed and the type of wound inflicted. The surgeons goal
surgical site involving only a few teeth, one cartridge must always be to minimize trauma to both the soft
(1.8 cc) of solution containing 1:50,000 epinephrine is and hard tissues involved in the surgical procedure.
usually sufficient to obtain adequate hemostasis. For Most periradicular surgical procedures require the rais-
more extensive surgery involving multiple teeth, it is ing of a mucoperiosteal flap.
rarely necessary to inject more than two cartridges (3.6 Flap Designs and Incisions. Good surgical access is
cc) of anesthetic (1:50,000 epinephrine) to achieve fundamentally dependent on the selection of an appro-
both anesthesia and hemostasis. priate flap design. Numerous flap designs have been pro-
Reactive Hyperemia: The Rebound Phenomenon. posed for periradicular surgery (Figure 12-11). It must
It is important that the endodontic surgeon be aware of be noted, however, that no one flap design is suitable for
the delayed beta-adrenergic effect that follows the hemo- all surgical situations. It is necessary to know the advan-
stasis produced by the injection of vasopressor amines. A tages and disadvantages of each flap design.
rebound occurs from an alpha (vasoconstriction) to a Principles and Guidelines for Flap Design.
beta (vasodilation) response and is termed reactive Regardless of the design of the surgical flap, there are a
hyperemia or the rebound phenomenon. 59 number of principles and guidelines that apply to the
Following the injection of a vasopressor amine, tis- location and extent of incisions. The adherence to these
sue concentration of the vasopressor gradually decreas- principles and guidelines will ensure that the flapped
es to a level that no longer produces an alpha-adrener- soft tissues will fit snugly in their original position and
gic vasoconstriction. The restricted blood flow slowly will properly cover the osseous wound site and provide
returns to normal but then rapidly increases far beyond an adequate vascular bed for healing:
normal, as a beta-adrenergic dilatation occurs.23,59,60
This rebound phenomenon is not the result of beta 1. Avoid horizontal and severely angled vertical inci-
receptor activity but results from localized tissue sions.
hypoxia and acidosis caused by the prolonged vasocon- The gingival blood supply is primarily from the same
striction.47,61 Once this reactive hyperemia occurs, it is vessels supplying the alveolar mucosa. As these vessels
usually impossible to re-establish hemostasis by addi- enter into the gingiva, they assume a vertical course
tional injections. Therefore, if a long surgical procedure parallel to the long axis of the teeth and are positioned
is planned (multiple roots or procedures), the more in the reticular layer superficial to the periosteum.
complicated and hemostasis-dependent procedures They are known as the supraperiosteal vessels.62,63
(root-end resection, root-end preparation and filling) They are arterioles with a diameter of about 100
should be done first. The less hemostasis-dependent m and are the terminal branches of the buccal, lin-
procedures, such as periradicular curettage, biopsy, or gual, greater palatine, inferior alveolar, and superior
root amputation, should be reserved for last. alveolar arteries.64
The rebound phenomenon has another important The collagen fibers of the gingiva and alveolar
clinical implication: postsurgical hemorrhage and mucosa provide structural strength to these tissues.
hematoma. These possible postsurgical sequelae are Collectively, these fibers are termed the gingival liga-
best minimized by proper soft-tissue repositioning ment. This ligament consists of a number of fiber
and postsurgical care, described in more detail later in groups that form attachments from crestal bone and
this chapter. supracrestal cementum to the gingiva and the perios-
teum on the buccal and lingual radicular bone. The
Soft-Tissue Management collagen fibers that attach to the periosteum course
The establishment of good surgical access, both visual over the crestal radicular bone in a direction parallel
and operative, is a requirement for all surgical proce- to the long axis of the teeth.65
Figure 12-11 Surgical flap design and nomenclature for flaps. A, Single vertical (tri-
angular). Above, Relaxing incision is vertical and placed over interdental bone.
Horizontal incision is in the gingival sulcus and releases the papillae as it extends lat-
erally. Below, Adequate access reaches periapical region of tooth involved in surgery
(arrow). More retraction may be gained by extending both vertical and horizontal inci-
sion. B, Double vertical (trapezoidal). Above, Oblique vertical incisions provide for a
broader base of the flap. They may cross, however, over radicular bone. Below,
Trapezoidal flap when fully reflected provides excellent access to the apices of teeth in
the surgical area. C, Double vertical (rectangular). Above, Recommended if bony fen-
estration is expected. Vertical relaxing incisions are placed over interdental bone and
not over radicular surfaces to avoid fenestrated root surfaces. Below, Excellent surgical
access is achieved to all periradicular areas of the teeth involved in the surgical area.
This flap design is recommended for maximum apical extension when needed. D,
Scalloped (Luebke-Ochsenbein). Above, This flap avoids interference with the archi-
tecture of the gingival sulcus and the interdental papillae. The horizontal incision is
placed parallel and just apical to the free gingival grove. A vertical relaxing incision is
placed at each of the terminal ends of the horizontal incision. Below, Surgical access is
good to the middle and apical periradicular areas but limited to the incisal one-third.
It is critical that solid bone support the incision when repositioning the flap.
Horizontal and severely angled incisions, such as severance of the gingival blood vessels that run per-
used in semilunar flaps and in broad-based rectan- pendicular to the line of incision.
gular flaps, shrink excessively during surgery as a 2. Avoid incisions over radicular eminences.
result of contraction of the cut collagen fibers that Radicular eminences, such as the canine, maxillary
run perpendicular to the line of incision. As a result first premolar, and first molar mesiobuccal root
of this shrinkage, it is often difficult to return the prominences, often fenestrate through the cortical
flap edges to their original position without placing bone or are covered by very thin bone with a poor
excessive tension on the soft tissues. This often blood supply. These bony defects may lead to soft-
results in tearing out of the sutures and subsequent tissue fenestrations if incisions are made over them.
scar formation from healing by secondary intention Vertical (releasing) incisions should be made paral-
(Figure 12-12). Horizontal or severely angled inci- lel to the long axis of the teeth and placed between
sions may also result in interference of the blood the adjacent teeth over solid interdental bone, never
supply to the unflapped gingival tissues because of over radicular bone (Figure 12-13).
Figure 12-13 Vertical incisions should be made over the thick Figure 12-14 The flap retractor should be broad enough to pro-
bone that lies in the trough (arrow) between the radicular emi- vide visual access to the surgical site and also rest on solid bone
nences. without impinging soft tissue.
A B
Figure 12-15 An incision should be no closer than 5 mm to a bony defect. A, Vertical incision is too close to bony defect. B, Incision placed
one tooth mesially allows for better visual access and solid bony support for the incision.
7. The junction of the horizontal sulcular and vertical 8. The flap should include the complete mucoperios-
incisions should either include or exclude the teum (full thickness).
involved interdental papilla. The flap should include the entire mucoperiosteum
Vertical releasing incisions should be made parallel (marginal, interdental and attached gingiva, alveolar
to the long axis of the teeth and placed between the mucosa, and periosteum). Full-thickness flaps result
adjacent teeth over solid interdental bone, never in less surgical trauma to the soft tissues and better
over radicular bone. The vertical incision should surgical hemostasis than do split-thickness flaps.
intersect the horizontal incision and terminate in The major advantages of full-thickness flaps are
the intrasulcular area at the mesial or distal line derived from the maintenance of the supraperiosteal
angle of the tooth. The involved interdental papilla blood vessels that supply these tissues.
should never be split by the vertical incision or inter-
sect the horizontal incision in the midroot area According to Gutmann and Harrison, the two major
(Figure 12-16). categories of periradicular surgical flaps are the full
mucoperiosteal flaps and the limited mucoperiosteal
flaps.2 The location of the horizontal component of the
incision is the distinguishing characteristic between the
two categories of surgical flaps. All full mucoperiosteal
flaps involve an intrasulcular horizontal incision with
reflection of the marginal and interdental (papillary)
gingival tissues as part of the flap. Limited mucope-
riosteal flaps have a submarginal (subsulcular) hori-
zontal or horizontally oriented incision, and the flap
does not include the marginal or interdental tissues.2
The addition of plane geometric terms to describe flap
designs, as suggested by Luebke and Ingle, provides for
an easily identifiable classification of periradicular sur-
gical flap designs.67 The classification of periradicular
surgical flaps is found in Table 12-2, and a description
of these flaps and their application in endodontic sur-
gery follows.
Full Mucoperiosteal Flaps. Triangular Flap. The
triangular flap is formed by a horizontal, intrasulcular
Figure 12-16 Incisions that split the papillae do not heal as well incision and one vertical releasing incision (Figure 12-
and may leave a periodontal defect following suture removal. 11, A). The primary advantages of this flap design are
Table 12-2 Classification of Surgical Flaps The major disadvantage of the rectangular flap
1. Full mucoperiosteal flaps design is the difficulty in reapproximation of the flap
(a) Triangular (one vertical releasing incision) margins and wound closure. Postsurgical stabilization
(b) Rectangular (two vertical releasing incisions) is also more difficult with this design than with the tri-
(c) Trapezoidal (broad-based rectangular) angular flap. This is primarily due to the fact that the
(d) Horizontal (no vertical releasing incision) flapped tissues are held in position solely by the
2. Limited mucoperiosteal flaps sutures. This results in a greater potential for postsurgi-
(a) Submarginal curved (semilunar) cal flap dislodgment. This flap design is not recom-
(b) Submarginal scalloped rectangular (Luebke-Ochsenbein) mended for posterior teeth.
Trapezoidal Flap. The trapezoidal flap is similar to
that it affords good wound healing, which is a result of the rectangular flap with the exception that the two
a minimal disruption of the vascular supply to the vertical releasing incisions intersect the horizontal,
flapped tissue, and ease of flap reapproximation, with a intrasulcular incision at an obtuse angle (see Figure 12-
minimal number of sutures required. The major disad- 11, B). The angled vertical releasing incisions are
vantage of this flap design is the somewhat limited sur- designed to create a broad-based flap with the vestibu-
gical access it provides because of the single vertical lar portion being wider than the sulcular portion. The
releasing incision. This limited surgical access often desirability of this flap design is predicated on the
makes it difficult to expose the root apexes of long teeth assumption that it will provide a better blood supply to
(eg, maxillary cuspids) and mandibular anterior teeth. the flapped tissues. Although this concept is valid in
In posterior surgery, both maxillary and mandibu- other tissues, such as the skin, its application is
lar, the vertical releasing incision is always placed at the unfounded in periradicular surgery.68
mesial extent of the horizontal incision, never the dis- Since the blood vessels and collagen fibers in the
tal. This affords the surgeon maximum visual and mucoperiosteal tissues are oriented in a vertical direc-
operative access with minimum soft-tissue trauma. For tion, the angled vertical releasing incisions will sever
anterior surgery, the vertical releasing incision should more of these vital structures. This will result in more
be placed at the extent of the horizontal incision that is bleeding, a disruption of the vascular supply to the
closest to the surgeon and is therefore dependent on unflapped tissues, and shrinkage of the flapped tissues.
the surgeons position to the right or left of the patient. The trapezoidal flap is contraindicated in periradicu-
After reflecting a triangular flap, sometimes the sur- lar surgery. 32,68
geon may find it necessary to obtain additional access. Horizontal Flap. The horizontal, or envelope, flap
This can be easily obtained by placement of a distal is created by a horizontal, intrasulcular incision with
relaxing incision. A relaxing incision is a short vertical no vertical releasing incision(s). This flap design has
incision placed in the marginal and attached gingiva very limited application in periradicular surgery
and located at the extent of the horizontal incision because of the limited surgical access it provides. Its
opposite the vertical releasing incision. This incision is major applications in endodontic surgery are limited to
also good for relieving flap retraction tension while repair of cervical defects (root perforations, resorption,
achieving adequate surgical access. caries, etc) and hemisections and root amputations.
As a result of the excellent wound-healing potential Limited Mucoperiosteal Flaps. Submarginal
of this flap design and the generally favorable surgical Curved (Semilunar) Flap. The submarginal or semi-
access it provides, use of the triangular mucoperiosteal lunar flap is formed by a curved incision in the alveolar
flap is recommended whenever possible. It is recom- mucosa and the attached gingiva (see Figure 12-11, E).
mended for maxillary incisors and posterior teeth. It is The incision begins in the alveolar mucosa extending
the only recommended flap design for mandibular into the attached gingiva and then curves back into the
posterior teeth because of anatomic structures con- alveolar mucosa. There are no advantages to this flap
traindicating other flap designs.2 design and its disadvantages are many, including poor
Rectangular Flap. The rectangular flap is formed surgical access and poor wound healing, which results
by an intrasulcular, horizontal incision and two vertical in scarring. This flap design is not recommended for
releasing incisions (see Figure 12-11, C). The major periradicular surgery.
advantage of this flap design is increased surgical access Submarginal Scalloped Rectangular (Luebke-
to the root apex. This flap design is especially useful for Ochsenbein) Flap. The submarginal scalloped rectan-
mandibular anterior teeth, multiple teeth, and teeth gular flap is a modification of the rectangular flap in
with long roots, such as maxillary canines. that the horizontal incision is not placed in the gingival
sulcus but in the buccal or labial attached gingiva. The Flap Design for Palatal Surgery. Periradicular sur-
horizontal incision is scalloped and follows the contour gery from a palatal approach is difficult due to the sur-
of the marginal gingiva above the free gingival groove geons limited visual and operative access to this area.
(Figure 12-11, D). The major advantages of this flap The only flap designs indicated for palatal approach
design are that it does not involve the marginal or surgery are the horizontal (envelope) and the triangu-
interdental gingiva and the crestal bone is not exposed. lar, with the latter being preferred. The palatal surgical
The primary disadvantages are that the vertically ori- approach should be limited to the posterior teeth.
ented blood vessels and collagen fibers are severed, Anterior teeth should be approached from the labial
resulting in more bleeding and a greater potential for aspect, except when radicular pathosis dictates a palatal
flap shrinkage, delayed healing, and scar formation. approach, for example, curettement of a cyst located
When considering the use of this flap design, the toward the palate.
endodontic surgeon must keep in mind that the hori- The horizontal intrasulcular incision for the trian-
zontal, scalloped incision must be placed and the flap gular flap should extend anteriorly to the mesial side of
repositioned over solid bone. Careful evaluation of any the first premolar or, for the horizontal (envelope) flap,
buccal or labial periodontal pockets must also be made to the midline. It should extend distally as far as need-
to minimize the possibility of leaving unflapped gingi- ed to afford access to the involved palatal root. A distal
val tissue without bony support. relaxing incision extending a few millimeters from the
The importance of properly angled diagnostic radi- marginal gingiva toward the midline or over the
ographs cannot be overemphasized when considering tuberosity area can be added to achieve better access
the use of this flap design. The size and position of any and to relieve tension on the distal extent of the flap.
periradicular inflammatory bone loss must also be The vertical releasing incision for the triangular flap
considered when placing the horizontal incision to should extend from a point near the midline and join
ensure that the margins of the flap, when reapproxi- the anterior extent of the horizontal incision mesial to
mated, will be adequately supported by solid bone. the first premolar. There is no validity to concerns
Proponents of this flap design stress the importance regarding a potential hemorrhage problem with verti-
of not involving the marginal gingiva and the gingival cal incisions in the palatal mucosa in the premolar area.
sulcus in the horizontal incision, which may result in The greater palatine artery branches rapidly as it cours-
an alteration of the soft-tissue attachment and crestal es anteriorly and an incision in the premolar area
bone levels. It has been reported, however, that, with results in a minimal disruption to the vascular supply.
proper reapproximation of the reflected tissues and The palatal mucosa is tough and fibrous, and flap
good soft-tissue management, the gingival attachment reflection and retraction can be difficult in this area.
level is minimally altered or unchanged when full Placement of a sling suture in the flapped tissue
mucoperiosteal flaps are used. attached to a tooth or a bite block on the opposite side
The key element in preventing loss of the soft-tissue of the maxillary arch may aid the surgeon in improving
attachment level is ensuring that the root-attached tis- visual and operative access by eliminating the need to
sues are not damaged or removed during surgery.6870 manually retract the flap while performing this poten-
It has also been reported that crestal bone loss is mini- tially difficult surgical procedure (Figure 12-17).
mal (about 0.5 mm) when full mucoperiosteal flaps are Incisions. Following the selection of the flap
used in periodontic surgery. These procedures may design, it is important to select the proper scalpel blade
involve apical positioning of flaps, excision of margin- to accomplish the delicate task of making smooth,
al gingiva, and root planing that must rely on new clean, atraumatic incisions. Incisions for the majority
attachment of soft tissue to cementum. Unlike peri- of mucoperiosteal flaps for periradicular surgery can
odontal surgery, endodontic surgery can accomplish be accomplished by using one or more of four scalpel
reattachment that results in little or no crestal bone blades: No. 11, No. 12, No. 15, and No. 15C (Figure 12-
loss.71 Harrison and Jurosky reported that crestal bone 18). The horizontal incision should be made first, fol-
showed complete osseous repair of resorptive defects lowed by the vertical releasing incisions to complete the
and no alteration of crestal height following periradic- perimeters of the flap design.
ular surgery using a triangular (full mucoperiosteal) The horizontal incision for a full mucoperiosteal
flap.70 In the absence of periodontal disease, a complete flap begins in the gingival sulcus and should extend
return to anatomic and functional normalcy can be through the fibers of the gingival attachment to the cre-
expected, following periradicular surgery using trian- stal bone. Care should be exercised to ensure that the
gular or rectangular flap designs.2 interdental papilla be incised through the midcol area,
Figure 12-19 No. 15C scalpel blade placed in the gingival sulcus
Figure 12-17 Single sling suture retracts palatal flap, giving surgi- for horizontal incision.
cal access and freeing hands of surgeon to hold mouth mirror and
handpiece. (Courtesy of Dr. Donald D. Antrim.)
separating the buccal and lingual papilla and incising The horizontal incision for a limited mucoperiosteal
the fibers of the epithelial attachment to crestal bone. flap should begin in the attached gingiva and be placed
Because these tissues are extremely delicate and space is about 2 mm coronal to the mucogingival junction
very limited, this important incision is best made with (Figure 12-20). The incision should be scalloped fol-
a small scalpel blade, such as No. 11 or No. 15C (Figure lowing the contour of the marginal gingiva. It is impor-
12-19). By holding the scalpel handle in a pen grasp tant that the horizontal incision never be placed coro-
and using finger rests on the teeth, the surgeon can nal to the depth of the gingival sulcus. The depth of the
achieve maximum control and stability when perform- gingival sulcus must be measured before placement of
ing these delicate incision strokes. An attempt should this flap design. The No. 15 or No. 15C scalpel blade is
be made to accomplish the horizontal incision using as recommended for this incision. An attempt should be
few incision strokes as necessary to minimize trauma to made to incise through the gingiva and periosteum to
the marginal gingiva. the cortical bone using firm pressure and a single,
smooth stroke. Multiple incision strokes will result in
increased trauma to the gingival tissue, which, in turn,
may contribute to retarded healing and scar formation.
Vertical releasing incisions, whether for full or limit-
ed mucoperiosteal flaps, should always be vertical and
placed between adjacent teeth over interdental bone.
They should never be placed over radicular bone. The
incision should penetrate through the periosteum so
that it can be included in the flap. The incision stroke
should begin in the alveolar mucosa and proceed in a
coronal direction until it intersects the horizontal inci-
sion (Figure 12-21). Contrary to a well-ingrained surgi-
cal axiom, it is not necessary to accomplish this incision
in a single stroke.2 It is often difficult to accomplish
penetration completely through the gingiva, mucosa,
submucosa, and periosteum in a single stroke of the
scalpel. An initial incision stroke that penetrates the
mucosa and gingiva can be followed by a second that
penetrates through the periosteum to the surface of the
Figure 12-18 Scalpel blades for surgical incisions. From top: cortical bone. More accurate placement of the vertical
Microsurgical blade, No. 15C, No. 15, No. 12, No. 11. releasing incision will often result from this two-stroke
Figure 12-20 Horizontal incision for submarginal scalloped rectangular flap is placed in the attached gingiva just apical to the free gingi-
val groove and follows the contour of the marginal gingiva. Patient biting on gauze can swallow more easily and prevents seepage of hemor-
rhage. (Courtesy of Dr. Donald D. Antrim.)
Figure 12-21 Vertical releasing incision should begin in the alveolar mucosa and proceed in a coronal direction until it intersects the hor-
izontal incision.
A B
Figure 12-25 Neurovascular bundle is seen in cadaver dissection exiting through the mental foramen (arrow). Notice its relationship to the
apices of both mandibular premolars.
base of the flap, mechanical trauma to the alveolar lesion may result in the loss of buccal or labial cortical
mucosa may result in delayed healing and increased plate, or if a natural root fenestration is present, the
postsurgical morbidity. tooth root may be visible through the cortical plate. In
There are a number of tissue retractors available for other cases, the cortical bone may be very thin, and
use in endodontic surgery (Figure 12-26). Selection of probing with a small sharp curette will allow penetra-
the proper size and shape of the retractor is important in tion of the cortical plate.
minimizing soft-tissue trauma. If the retractor is too The most difficult and challenging situation for the
large, it may traumatize the surrounding tissue. If the endodontic surgeon occurs when several millimeters of
retractor is too small, flapped tissue falls over the retrac- cortical and cancellous bone must be removed to gain
tor and impairs the surgeons access. This results not access to the tooth root, especially when no periradicu-
only in increased soft-tissue trauma but also in extend- lar radiolucent lesion is present. A number of factors
ing the length of the surgical procedure. An axiomatic should be considered to determine the location of the
principle of endodontic surgery is that the longer the bony window in this clinical situation. The angle of the
flap is retracted, the greater the postsurgical morbidity. crown of the tooth to the root should be assessed.
This is a logical conclusion based on the probability that Often the long axis of the crown and its root are not the
blood flow to the flapped tissues is impeded during flap same, especially when a prosthetic crown has been
retraction. In time, this will result in hypoxia and acido- placed. When a root prominence or eminence in the
sis with a resulting delay in wound healing.2,23,59 cortical plate is present, the root angulation and posi-
Regardless of whether the retraction time is short or tion are more easily determined. Measurement of the
long, the periosteal surface of the flap should be irri- entire tooth length can be obtained from a well-angled
gated frequently with physiologic saline (0.9% sodium radiograph and transferred to the surgical site by the
chloride) solution. Saline should be used rather than use of a sterile millimeter ruler. After a small defect has
water because the latter is hypotonic to tissue fluids. It been created on the surface of the cortical plate, a
is not necessary to irrigate the superficial surface of the radiopaque marker, such as a small piece of lead foil
flap because the stratified squamous epithelium pre- from a radiographic film packet or a small piece of
vents dehydration from this surface. Limited mucope- gutta percha, can be placed in the bony defect and a
riosteal flaps are more susceptible to dehydration and direct (not angled) radiograph exposed. The
may require more frequent irrigation than would full radiopaque object will provide guidance for the posi-
mucoperiosteal flaps.2 tion of the root apex.7679
When the cortical plate is intact, another method to
Hard-Tissue Management
locate the root apex is to first locate the body of the
Following reflection and retraction of the mucope- root substantially coronal to the apex where the bone
riosteal flap, surgical access must be made through the covering the root is thinner. Once the root has been
cortical bone to the roots of the teeth. Where cortical located and identified, the bone covering the root is
bone is thin, as in the maxilla, a large periradicular slowly and carefully removed with light brush strokes,
working in an apical direction until the root apex is
identified (Figure 12-27). Barnes identified four ways
in which the root surface can be distinguished from the
surrounding osseous tissue: (1) root structure general-
ly has a yellowish color, (2) roots do not bleed when
probed, (3) root texture is smooth and hard as opposed
to the granular and porous nature of bone, and (4) the
root is surrounded by the periodontal ligament.80
Under some clinical conditions, however, the root
may be very difficult to distinguish from the surround-
ing osseous tissue. Some authors advocate the use of
methylene blue dye to aid in the identification of the
periodontal ligament. A small amount of the dye is
painted on the area in question and left for 1 to 2 min-
utes. When the dye is washed off with saline, the peri-
Figure 12-26 Flap retractors. Top: No. G3 (Hu-Friedy); Middle: No. odontal ligament will be stained with the dye, making
3 (Hu-Friedy); Bottom: Rubinstein (JedMed Co., St. Louis, MO). it easier to identify the location of the root.32,77,81,82
of the surgery: root-end resection and root-end filling. result in increased hemorrhage and shredding the tissue
Although it is advisable to limit osseous tissue removal will result in more difficult removal. To accomplish
to no more than is necessary, failure to achieve suffi- removal of the entire tissue mass, the largest bone curette,
cient visual and operative access results in extending consistent with the size of the lesion, is placed between
the time required for the surgical procedure, increasing the soft-tissue mass and the lateral wall of the bony crypt
the stress level of the surgeon, trauma to adjacent tis- with the concave surface of the curette facing the bone.
sues, and postsurgical patient morbidity. Pressure should be applied against the bone as the curette
is inserted between the soft-tissue mass and the bone
Periradicular Curettage around the lateral margins of the lesion. Once the soft tis-
Once the root and the root apex have been identified sue has been freed along the periphery of the lesion, the
and the surgical window through the cortical and bone curette should be turned with the concave portion
medullary bone has been properly established, any dis- toward the soft tissue and used in a scraping fashion to
eased tissue should be removed from the periradicular free the tissue from the deep walls of the bony crypt.
bony lesion. This removal of periradicular inflammato- Again, care should be taken not to penetrate the soft-tis-
ry tissue is best accomplished by using the various sizes sue mass with the curette.
and shapes of sharp surgical bone curettes and angled Once the tissue has been detached from the walls of
periodontal curettes (Figure 12-29). Several instrument the crypt, its removal can be facilitated by grasping it
manufacturers provide a wide assortment of curettes with a pair of tissue forceps. The tissue should be
that can be used for dbridement of the soft tissue immediately placed in a bottle containing 10%
located adjacent to the root. The choice of specific buffered formalin solution for transportation to the
curettes is very subjective, and endodontic surgeons pathology laboratory. Although the majority of peri-
will develop a preference for curettes that work best for radicular lesions of pulpal origin are granulomas,
them. It is advisable, however, to have a wide assort- radicular cysts, or abscesses, a multitude of benign and
ment of curettes available in the sterile surgery pack to neoplastic lesions have been recovered from periradic-
use should the need arise. ular areas.97 All soft tissue removed during periradicu-
Before proceeding with periradicular curettage, it is lar curettage should be sent for histopathologic exami-
advisable to inject a local anesthetic solution contain- nation to ensure that no potentially serious pathologic
ing a vasoconstrictor into the soft-tissue mass. This will condition exists.98
reduce the possibility of discomfort to the patient dur- When the periradicular inflammatory soft tissue
ing the dbridement process and will also serve as hem- cannot be removed as a total mass, dbridement is
orrhage control at the surgical site. Additional injec- much more difficult and time consuming. As demon-
tions of local anesthetic solution may be necessary if strated by Fish, there is a considerable amount of
the amount of soft tissue needing to be removed is reparative tissue in periradicular lesions.99 Although it
extensive and hemorrhage control is a problem. has been advocated for many years that all the soft tis-
Curettement of the inflammatory soft tissue will be sue adjacent to the root be removed during periradicu-
facilitated if the tissue mass can be removed in one piece. lar surgery, in theory and practice this may not be nec-
Penetration of the soft-tissue mass with a curette will essary. This is especially true in cases where the lesion
invades critical anatomic areas and structures such as
the maxillary sinus, nasal cavity, mandibular canal, or
adjacent vital teeth. Curettement of soft tissue in these
and other critical anatomic areas should be avoided.2
Root-End Resection
Root-end resection is a common yet controversial
component of endodontic surgery. Historically, many
authors have advocated periradicular curettage as the
definitive treatment in endodontic surgery without
root-end resection. Their rationale for this approach
centered primarily around the perceived need to main-
tain a cemental covering on the root surface and to
Figure 12-29 Assorted curettes for removing periradicular maintain as much root length as possible for tooth sta-
inflammatory soft tissue. bility.100102 According to Gutmann and Harrison, no
the root than either the No. 57 or the Lindeman bur. The Maillet and associates evaluated the connective-tis-
multifluted carbide finishing bur tended to improve the sue response to healing adjacent to the surface of
smoothness of the resected root face, whereas the ultra- dentin cut by a Nd:YAG laser versus dentin cut by a fis-
fine diamond tended to roughen the surface.108 sure bur. Disks of human roots 3.5 mm thick were
Since Theodore H. Maiman produced light amplifi- implanted in the dorsal subcutaneous tissue of rats for
cation by stimulated emission of radiation (LASER) in 90 days. The disks were then recovered, with the sur-
1960, lasers have found application in many areas of rounding tissue, at various times. The tissue against the
industry and medicine. Laser technology has been cut dentin surfaces was assessed for extent of inflam-
developed very rapidly and is now being used in vari- mation and fibrous capsule thickness by light
ous fields of dentistry. Most lasers used in dentistry microscopy. Their results showed a statistically signifi-
operate either in the infrared or visible regions of the cant increase in inflammation and fibrous capsule
electromagnetic spectrum. These lasers act by produc- thickness adjacent to the dentin surfaces cut with the
ing a thermal effect. This means that the laser beam, Nd:YAG laser compared with the bur-cut surfaces.112
when absorbed, has the capability to coagulate, vapor- Miserendino submitted a case report in which the
ize, or carbonize the target tissue. It is important to CO2 laser was used to perform a root-end resection
note that different types of lasers may have different and to sterilize the unfilled apical portion of the root
effects on the same tissue and the same laser may have canal space. He stated that the rationale for laser use in
different effects on different tissues. endodontic periradicular surgery includes (1)
Recently, many investigators have studied and improved hemostasis and concurrent visualization of
reported on the in vitro and in vivo effects of the appli- the operative field, (2) potential sterilization of the
cation of laser energy for root-end resections in contaminated root apex, (3) potential reduction in per-
endodontic periradicular surgery. A team of investiga- meability of root-surface dentin, (4) reduction of post-
tors from the Tokyo Medical and Dental University in operative pain, and (5) reduced risk of contamination
Japan reported on an in vitro study using the Er:YAG of the surgical site through elimination of the use of
laser for root-end resections. They reported that there aerosol-producing air turbine handpieces. He conclud-
was no smear layer or debris left on the resected root ed that the initial results of the clinical use of the CO2
surfaces prepared by the use of the Er:YAG laser. Smear laser for endodontic periradicular surgery confirms the
layer and debris, however, were left on the root surfaces previous in vitro laboratory findings and indicates that
prepared with a fissure bur.109 further study of the application of lasers for microsur-
Komori and associates reported on an in vitro study gical procedures in endodontics is in order.113
evaluating the use of the Er:YAG laser and the Ho:YAG Komori and associates recently reported on eight
laser for root-end resections. They reported that the patients (13 teeth) in whom the Er:YAG laser was used
Er:YAG laser produced smooth, clean, resected root for root-end resections in periradicular endodontic
surfaces free of any signs of thermal damage. The surgery. They reported that all procedures were per-
Ho:YAG laser, however, produced signs of thermal formed without the use of a high- or low-speed dental
damage and large voids between the gutta-percha root handpiece. Although the cutting speed of the laser was
canal fillings and the root canal walls.110 slightly slower than with the use of burs, the advantages
Moritz and associates reported on an in vitro study of the laser included the absence of discomfort and
evaluating the use of the carbon-dioxide (CO2) laser vibrations, less chance for contamination of the surgi-
as an aid in performing root-end resections. They cal site, and reduced risk of trauma to adjacent tissue114
chose the laser because it had previously been shown (Figure 12-31).
to have a sealing effect on the dentinal tubules. Their Extent of the Root-End Resection. William
results indicated that the use of the CO2 laser as an Hunters classic presentation on the role of sepsis and
adjunct following root-end resection with a fissure antisepsis in medicine had an impact that lasted for
bur resulted in decreased dentin permeability, as many years on the extent of root-end resections in peri-
measured by dye penetration and sealing of dentinal radicular surgery. Historically, it was believed that fail-
tubules determined by SEM examination. Their con- ure to remove all foci of infection could result in a per-
clusion was that CO2 laser treatment optimally pre- sistence of the disease process. Since the portion of the
pares the resected root-end surface to receive a root- root that extended into the diseased tissue was infect-
end filling because it seals the dentinal tubules, elimi- ed, and the cementum was necrotic, it was necessary
nates niches for bacterial growth, and sterilizes the to resect the root to the level of healthy bone.
root surface.111 Andreasen and Rud, in 1972, were unable to demon-
A B C
Figure 12-31 Root-end resection using LASER energy. A, Pretreatment radiograph revealing failing endodontic treatments with periradic-
ular inflammatory lesions. B, Radiograph following endodontic retreatment and root-end resection of teeth No. 9 and No. 10 using Er:YAG
laser. C, Twenty-six-month postsurgical radiograph revealing good periradicular healing. (Courtesy of Dr. Silvia Cecchini.)
strate the validity of this concept. Their findings indi- 6. Presence and extent of periodontal defects.
cated that there was no correlation between the pres- 7. Level of remaining crestal bone.
ence of microorganisms in the dentinal tubules and the
degree of periradicular inflammation.115 The endodontic surgeon must constantly be aware
The extent of root-end resection will be determined that conservation of tooth structure during root-end
by a number of variable factors that a dental surgeon resection is desirable; however, root conservation
must evaluate on an individual, case-by-case basis. It is should not compromise the goals of the surgical proce-
not clinically applicable to set a predetermined amount dure (Figure 12-32).
of root-end removal that will be appropriate for all Angle of Root-End Resection. Historically,
clinical situations. The following factors should be con- endodontic textbooks and other literature have recom-
sidered when determining the appropriate extent of mended that the angle of root-end resections, when
root-end resection in periradicular surgery: used in periradicular surgery, should be 30 degrees to
45 degrees from the long axis of the root facing toward
1. Visual and operative access to the surgical site the buccal or facial aspect of the root. The purpose for
(example: resection of buccal root of maxillary first the angled root-end resections was to provide
premolar to gain access to the lingual root). enhanced visibility to the resected root end and opera-
2. Anatomy of the root (shape, length, curvature). tive access to enable the surgeon to accomplish a root-
3. Number of canals and their position in the root end preparation with a bur in a low-speed hand-
(example: mesial buccal root of maxillary molars, piece.2,3,29,32,63,7678,103
mesial roots of mandibular molars, two canal More recently, several authors have presented evi-
mandibular incisors). dence indicating that beveling of the root end results in
4. Need to place a root-end filling surrounded by solid opening of dentinal tubules on the resected root sur-
dentin (because most roots are conical shaped, as face that may communicate with the root canal space
the extent of root-end resection increases, the sur- and result in apical leakage, even when a root end fill-
face area of the resected root face increases). ing has been placed. Ichesco and associates, using a
5. Presence and location of procedural error (example: spectrophotometric analysis of dye penetration, con-
perforation, ledge, separated instrument, apical cluded that the resected root end of an endodontically
extent of orthograde root canal filling). treated tooth exhibited more apical leakage than one
B C
Figure 12-32 A, Mandibular canine abutment found to have two canals (arrows) on surgical exposure. B, One-year recall of A, with com-
plete healing. C, Two-canal mandibular incisors serving as double abutments. Larger retrofillings obturate two foramina to rescue case.
(Courtesy of Dr. L. Stephen Buchanan.)
without root-end resection.116 Beatty, using a similar Tidmarsh and Arrowsmith examined the cut root
method of dye penetration analysis, examined apical surface following root-end resections at angles between
leakage at different root-end resection angles and 45 degrees and 60 degrees approximately 3 mm from
reported that significantly more leakage occurred in the root apex. Using scanning electron microscopy,
those roots where the root-end filling did not extend to they reported the presence of an average of 27,000
the height of the bevel.117 Vertucci and Beatty proposed dentinal tubules per mm2 on the face of the root-end
that exposed dentinal tubules may constitute a poten- resection midway between the root canal and the den-
tial pathway for apical leakage.118 tinecementum junction.119
Gagliani and associates assessed the apical leakage often have a straightforward, uncomplicated root canal
measured by dye penetration in extracted teeth with system, except for lateral or accessory canals, usually
root-end resections at 45-degree and 90-degree angles located in the apical one-third of the root.
from the long axis of the root. Their findings indicated Roots with multiple canals, however, have the poten-
a statistically significant increase in leakage extending to tial to have more complicated root canal systems. An
the root canal space through dentinal tubules in those isthmus or anastomosis may exist between two root
teeth with 45-degree angled root-end resections. They canals in the same root.121 This isthmus connection,
concluded that, by increasing the angle of the root-end when it occurs, becomes an important factor in the abil-
resection from the long axis of the root, the number of ity to thoroughly clean and dbride these root canal sys-
exposed dentinal tubules increases. If infection persists tems (Figure 12-33). They also become a significant fac-
within the root canal system coronal to the root-end fill- tor in the design and placement of the root-end prepa-
ing, the likelihood of bacteria and/or bacterial by-prod- ration. If an isthmus exists and is not included in the
ucts spreading outside of the root canal is high.120 root-end preparation, the remaining necrotic pulp tissue
Regardless of the angle or the extent of the root-end and debris may be a nidus for recurrent infection and
resection, it is extremely important that the resection subsequent treatment failure. The use of methylene blue
be complete and that no segment of root is left unre- dye placed on the resected root surface can also aid in the
sected. The potential for incomplete root-end resection detection of an existing root canal isthmus.
is especially high in cases where the root is broad in its Several authors have reported on studies investigat-
labiallingual dimension and where surgical access and ing the actual incidence of an isthmus being present
visibility are impaired. Carr and Bentkover stated that between two root canals in the same root. These
failure to cut completely through the root in a buc- reports indicate that the mesial root of the mandibular
callingual direction is one of the most common errors first molar has the highest incidence, at 89%, followed
in periradicular surgery.82 Once the desired extent and by the mesiobuccal root of the maxillary first molar, at
bevel of root-end resection have been achieved, the face 52%.122127 In the past, the existence of a canal isthmus
of the resected root surface should be carefully exam- was often overlooked, and when identified, it was diffi-
ined to verify that complete circumferential resection cult to prepare with the traditional bur preparation.
has been accomplished. This can be accomplished by The recognition and proper management of a canal
using a fine, sharp explorer or the tip of a Morse scaler isthmus is an important factor that may affect the suc-
guided around the periphery of the resected root sur- cess of periradicular surgery involving roots with two
face. If complete resection is in doubt, a small amount or more canals.
of methylene blue dye can be applied to the root sur- Importance of Surgical Hemostasis. Good visual-
face for 5 to 10 seconds. After the area has been irrigat- ization of the surgical field and of the resected root sur-
ed with sterile saline, the periodontal ligament will face is essential in determining the optimum placement
appear dark blue, thereby highlighting the root outline. of the root-end preparation. The ability to visualize the
fine detail of the anatomy on the resected root surface
Root-End Preparation depends on excellent surgical hemostasis to provide a
The purpose of a root-end preparation in periradicular clean, dry, surgical site. Presurgical hemostasis was dis-
surgery is to create a cavity to receive a root-end filling. cussed earlier in this chapter and its importance cannot
Historically, root-end preparations have been per- be overemphasized. Frequently, however, the need for
formed by the use of small round or inverted cone burs additional hemostasis at the surgical site becomes evi-
in a miniature or straight low-speed handpiece. One dent. This surgical hemostasis is best achieved by the
major objective of a root-end preparation is that it be use of various topical or local hemostatic agents.
placed parallel to the long axis of the root. It is rare that Ideally, these hemostatic agents should be placed sub-
sufficient access is present to allow a bur in a contra sequent to the root-end resection and before the root-
angle or straight handpiece to be inserted down the end preparation and filling.2 These topical and local
long axis of the root. These preparations are almost hemostatic agents have been broadly classified by their
always placed obliquely into the root with a high risk of mechanism of action128 (see Table 12-3).
perforation to the lingual. Bone Wax. The recommended use of bone wax
It is important for proper root-end preparation that dates back more than 100 years.128 In 1972, Selden
the endodontic surgeon have a thorough knowledge of reported bone wax to be an effective hemostatic agent
the root canal morphology of the tooth being treated. in periradicular surgery.129 Bone wax contains mostly
Incisor teeth with single roots and single canals most highly purified beeswax with the addition of small
Table 12-3 Classification of Topical Hemostatic amounts of softening and conditioning agents. Its
Agents hemostatic mechanism of action is purely mechanical
in that the wax, when placed under moderate pressure,
1. Mechanical agents (Nonresorbable)
plugs the vascular openings. It has no effect on the
a. Bone wax (Ethicon, Somerville, NJ)
blood-clotting mechanism.
2. Chemical agents When using bone wax for surgical hemostasis, it
a. Vasoconstrictors: epinephrine (Racellets, Epidri, should first be packed firmly into the entire bony cavi-
Radri) (Pascal Co, Bellevue, WA) ty. The excess should then be carefully removed with a
b. Ferric sulfate: Stasis (Cut-Trol, Mobile, AL); curette until only the root apex is exposed. When the
Viscostat; Astringedent (Ultradent Products, Inc, UT)
root-end surgical procedure is completed, all remain-
3. Biologic agents ing bone wax should be thoroughly removed before
a. Thrombin USP: Thrombostat (Parke-Davis, Morris surgical closure. Numerous authors, however, have
Plains, NJ); Thrombogen (Johnson & Johnson reported the presence of persistent inflammation, for-
Medical, New Brunswick, NJ) eign-body giant cell reactions, and delayed healing at
4. Absorbable hemostatic agents the surgical site following the use of bone wax.130133
a. Mechanical agents With the availability of more biocompatible and
i. Calcium sulfate USP biodegradable products for local hemostasis, bone wax
b. Intrinsic action agents can no longer be recommended for use in periradicu-
i. Gelatin: Gelfoam (Upjohn Co, Kalamazoo, MI); lar surgery. 2,134
Spongostan (Ferrostan, Copenhagen, Denmark) Vasoconstrictors. Vasoconstrictors, such as epi-
ii. Absorbable collagen: Collatape (Colla-tec Inc, nephrine, phenylephrine, and nordefrin, have been rec-
Plainsboro, NJ); Actifoam (Med-Chem Products ommended as topical agents for hemorrhage control
Inc, Boston, MA) during periradicular surgery. Of these agents, epineph-
iii. Microfibrillar collagen hemostats: Avitene rine has been shown to be the most effective and the
(Johnson & Johnson, New Brunswick, NJ) most often recommended.2,128,135,136 Cotton pellets
c. Extrinsic action agents containing racemic epinephrine in varying amounts
i. Surgicel (Johnson & Johnson, New Brunswick, NJ) (Epidri, Racellete, Radri) are available (Figure 12-34).
USP = United States Pharmacopeia. For example, each Epidri pellet contains 1.9 mg of
Figure 12-34 Racellet Pellets (Pascal Co, Bellevue, WA). Each pel- Figure 12-35 Telfa pads contain no cotton fibers and can be cut
let contains 0.55 mg of racemic epinephrine. Epidri pellets (Pascal into small squares that are easily adapted to the surgical site.
Co) contain 1.9 mg racemic epinephrine.
racemic epinephrine. Each Racellete No. 2 pellet con- periradicular surgery, the pulse rate of the patient did
tains 1.15 mg and each Racellete No. 3 pellet contains not change.137 Pallasch has stated that, although the use
0.55 mg of epinephrine. Radri pellets contain a combi- of vasoconstrictors in topical hemostatic agents and
nation of vasoconstrictor and astringent. Each Radri gingival retraction cord remains controversial, data
pellet contains 0.45 mg of epinephrine and 1.85 mg of exist from which to formulate reasonable guidelines.
zinc phenolsulfonate. Elevated blood levels of epinephrine can occur with
Two areas of concern when using cotton pellets con- their use but do not generally appear to be associated
taining epinephrine need to be addressed. The first is the with any significant cardiovascular effects in healthy
potential for leaving cotton fibers in the surgical site and patients or those with mild to moderate heart disease.
the second is the possible hemodynamic effect of epi- In patients with more severe heart disease, epineph-
nephrine on the vascular system. Gutmann and rine-impregnated cotton pellets or gauze, or gingival
Harrison stated that cotton fibers that are left at the sur- retraction cord, should be used with caution or avoid-
gical site may impair the actual root-end seal by being ed.138 Kim and Rethnam, however, have stated that,
trapped along the margins of the root-end filling mate- because epinephrine used topically causes immediate
rial.2 They also stated that cotton fibers may serve as for- local vasoconstriction, there is little absorption into the
eign bodies in the surgical site and result in impaired systemic circulation and thus a reduced chance of a sys-
would healing. Cotton pellets and gauze products con- temic effect.128
taining cotton should, therefore, be considered the least Ferric Sulfate. Ferric sulfate is a chemical agent
desirable materials to be used for root-end isolation or that has been used as a hemostatic agent for over 100
hemostasis. Sterile Telfa pads (Kendall Co., Mansfield, years. It was first introduced as Monsels solution (20%
Mass.) are useful adjuncts as they contain no cotton ferric sulfate) in 1857. Its mechanism of action results
fibers. They can be cut into small squares that are easily from the agglutination of blood proteins and the acidic
adapted to the surgical site (Figure 12-35). pH (0.21) of the solution. In contrast to vasoconstric-
Weine and Gerstein and Selden have cautioned tors, ferric sulfate effects hemostasis through a chemi-
against the use of vasoconstrictors as topical agents for cal reaction with the blood rather than an alpha-adren-
hemostasis during periradicular surgery because their ergic effect.128
use may result in systemic vascular change.76,129 Besner, Ferric sulfate is easy to apply, requires no applica-
however, has shown that when a Racellete No. 2 pellet tion of pressure, and hemostasis is achieved almost
containing 1.15 mg of epinephrine was used during immediately (Figure 12-36). Ferric sulfate, however, is
A C
Figure 12-36 Hemodent (Premier Dental; King of Prussia, Pa.). A, Ferric sulfate achieves hemostasis as a result of agglutination of blood pro-
teins rather than from an alpha-adrenergic effect like epinephrine. B, An Infusion Tip (Ultradent Products Inc., Utah) placed on a 1.0 cc syringe
(Monoject) containing a small amount of ferric sulfate solution. The infusion tip allows for controlled placement of the hemostatic agent.
C, Close-up of infusion tip.
known to be cytotoxic and may cause tissue necrosis effective as other available topical hemostatic
and tattooing. Systemic absorption is unlikely agents.134 In a report of a study by Codben and asso-
because the agglutinated protein plugs that occlude ciates, no impedance of bone healing was evident 3
the blood-vessel orifices isolate it from the vascular months following the use of topical thrombin.141
supply. 128 Lemon and associates, using rabbit Topical thrombin has been used successfully in neu-
mandibles, reported a significant adverse effect on rosurgery, cardiovascular surgery, and burn surgery;
osseous healing when ferric sulfate was left in the sur- however, its use in periradicular surgery has not been
gical site following creation of experimental surgical adequately investigated at this time. The main disad-
bony defects.139 Jeansonne and associates, however, vantages of topical thrombin are its difficulty of han-
using a similar rabbit model, reported that when fer- dling and high cost.
ric sulfate was placed only until hemostasis was Calcium Sulfate. Calcium sulfate (plaster of Paris)
obtained and the surgical site was thoroughly curetted is a resorbable material used in surgery for over 100
and irrigated with sterile saline 5 minutes later, there years. It has gained popularity, in recent years, as a bar-
was no significant difference in osseous repair, as rier material in guided tissue-regeneration proce-
compared with the untreated controls.140 Ferric sul- dures.142,143 Calcium sulfate can also be used as a hemo-
fate appears to be a safe hemostatic agent when used static agent during periradicular surgery. It consists of a
in limited quantities and care is taken to thoroughly powder and liquid component that can be mixed into a
curette and irrigate the agglutinated protein material thick putty-like consistency and placed in the bony
before surgical closure.128 crypt using wet cotton pellets to press it against the
Thrombin. Topical thrombin has been developed walls. The hemostatic mechanism of calcium sulfate is
for hemostasis wherever wounds are oozing blood similar to bone wax in that it acts as a mechanical bar-
from small capillaries and venules. Thrombin acts to rier, plugging the vascular channels. In contrast to bone
initiate the extrinsic and intrinsic clotting pathways. wax however, calcium sulfate is biocompatible, resorbs
It is designed for topical application only and may be completely in 2 to 4 weeks, and does not cause an
life threatening if injected. Topical thrombin has increase in inflammation. It is porous, which allows for
been investigated as a hemostatic agent in abating fluid exchange so that flap necrosis does not occur when
bleeding in cancellous bone. Although there was less left in place following surgery. Calcium sulfate also has
bleeding than in the control, thrombin was not as the advantage of being relatively inexpensive.128
Gelfoam and Spongostan. Gelfoam and Spongostan dry, directly to the bleeding site, while using pressure.
are hard, gelatin-based sponges that are water insoluble Hemostasis is usually achieved in 2 to 5 minutes.128
and resorbable. They are made of animal-skin gelatin Microfibrillar Collagen Hemostat. Avitene and
and become soft on contact with blood. Gelatin sponges Instat are two popular forms of microfibrillar collagen.
are thought to act intrinsically by promoting the disinte- It is derived from purified bovine dermal collagen,
gration of platelets, causing a subsequent release of shredded into fibrils, and converted into an insoluble
thromboplastin. This, in turn, stimulates the formation partial hydrochloric acid salt. It functions through top-
of thrombin in the interstices of the sponge.128 ical hemostasis, providing a collagen framework for
The main indication for the use of gelatin-based platelet adhesion. This initiates the process of platelet
sponges is to control bleeding in surgical sites by leav- aggregation and adhesion and formation of a platelet
ing it in situ, such as in extraction sockets, where plug.150 Avitene has been recommended as a viable
hemostasis cannot be achieved by the application of means of controlling hemorrhage in periodontal sur-
pressure. During periradicular surgery, hemostasis is gery, resulting in a minimal interference in the osseous
needed for improved visualization to accomplish the wound-healing process.151,152, Haasch and associates
delicate task of root-end resection and filling. Once the have demonstrated its potential use in periradicular
gelatin sponge contacts blood, it swells and forms a surgery.153 In a study designed to examine osseous
soft, gelatinous mass. This swollen, soft, gelatinous regeneration in the presence of Avitene, Finn and asso-
mass tends to visually obscure the surgical site. Because ciates found that bone formation proceeded unevent-
it is soft, pressure cannot be applied to the severed fully without a foreign-body reaction.154
microvasculature without dislodging the gelatin The application of microfibrillar collagen products
sponge, which will result in a continuation of bleeding. may be difficult and tedious, at times, because of their
The major use for gelatin-based sponges in periradicu- affinity for wet surfaces, such as instruments and
lar surgery is placement in the bony crypt, after root- gloves. To overcome these problems, it has been recom-
end resection and root-end filling have been completed mended that they be applied to the surgical site by use
just before wound closure. Because gelatin-based of a spray technique. This allows direct application of
sponges promote disintegration of platelets, release of the hemostatic agent to the bleeding points.155 Other
thromboplastin, and the formation of thrombin, they disadvantages of microfibrillar collagen products: they
may be beneficial in reducing postsurgical bleeding are inactivated by autoclaving, their use in contaminat-
from the rebound phenomenon. ed wounds may enhance infection, and they are expen-
The initial reaction to gelatin-based sponge material sive compared with other topical hemostatic agents.128
in the surgical site is a reduction in the rate of osseous Surgicel. Surgicel is a chemically sterilized sub-
healing. Boyes-Varley and associates examined early stance resembling surgical gauze and is prepared by the
healing in the extraction sockets of monkeys. oxidation of regenerated cellulose (oxycellulose), which
Histologically, the sockets containing gelatin-based is spun into threads, then woven into a gauze that is
sponge material displayed a greater inflammatory cell sterilized with formaldehyde. Its mode of action is
infiltrate, marked reduction in bone in-growth, and a principally physical since it does not affect the clotting
foreign-body reaction at 8 days.144 Olson and associ- cascade through aggregation or adhesion of platelets,
ates, however, reported that there was no distinguish- such as the collagen-based products. Surgicel initially
able difference in healing rate or inflammatory cell acts as a barrier to blood and then as a sticky mass that
infiltrate between extraction sockets in which Gelfoam acts as an artificial coagulum or plug.134
was placed and the controls after 90 days.145 Surgicel left in bone following surgery has been
Collagen. Collagen-based products have been used shown to markedly reduce the rate of repair and
extensively as surgical hemostatic agents. It is believed increase inflammation. Difficulty in completely remov-
that four principal mechanisms of action are involved ing Surgicel from bony wounds has been described,
in hemostasis enhanced by collagen-based products: with even minimally retained fragments resulting in
(1) stimulation of platelet adhesion, aggregation, and inflammation and a foreign-body reaction.130 The
release reaction146; (2) activation of Factor VIII manufacturer, Johnson and Johnson, does not recom-
(Hageman Factor)147; (3) mechanical tamponade mend implantation of Surgicel in bony defects.156
action148; and (4) the release of serotonin.149 The colla- Instrumentation. Root-end preparation tech-
gen used for surgical hemostasis is obtained from niques have historically involved a recommendation
bovine sources and is supplied in sheets (Collatape) that the endodontic surgeon, following the root-end
and sponge pads (Actifoam). Both forms are applied resection, examine the root canal filling to determine
the quality of the seal. Adequately evaluating the qual- require periradicular surgery are often those in which
ity of seal of a root canal filling requires measure- the anatomy is unusual or complex.82
ments in the area of microns, and we currently do not Bur Preparation. The traditional root-end cavity
possess these capabilities at a clinical level. SEM stud- preparation technique involved the use of either a
ies have shown that the act of root-end resection dis- miniature contra angle or straight handpiece and a
turbs the gutta-percha seal.157,158 The preparation small round or inverted cone bur. The objective was to
for, and the placement of, a root-end filling is there- prepare a class I cavity preparation down the long axis
fore recommended whenever root-end resection has of the root within the confines of the root canal. The
been performed.82 recommended depth of the preparation ranged from 1
Root-end preparations should accept filling materi- to 5 mm, with 2 to 3 mm being the most commonly
als that predictably seal off the root canal system from advocated.76,78,104
the periradicular tissues. Carr and Bentkover have The ability of the endodontic surgeon to prepare a
defined an ideal root-end preparation as a class I prepa- class I cavity parallel to the long axis of the root with a
ration at least 3.0 mm into root dentin with walls par- miniature contra angle handpiece may be difficult and
allel to and coincident with the anatomic outline of the depends on the physical access available around the
pulp space.82 They also identified five requirements root apex. According to Arens et al., this requires a min-
that a root-end preparation must fulfill: imum of 10 mm above or below the point of entry.32
Accomplishing this with a straight handpiece is virtual-
1. The apical 3 mm of the root canal must be freshly ly impossible. These preparations are most often placed
cleaned and shaped. obliquely into the root, resulting in a risk of perfora-
2. The preparation must be parallel to and coincident tion and/or weakening of the dentin walls, and predis-
with the anatomic outline of the pulp space. posing to a possible root fracture (Figure 12-37, A).
3. Adequate retention form must be created. Ultrasonic Root-End Preparation. Ultrasonic
4. All isthmus tissue, when present, must be removed. root-end preparation techniques have been developed
5. Remaining dentin walls must not be weakened. in an attempt to solve the major inadequacies and
shortcomings of the traditional bur-type preparation.
For successful root-end preparations, the endodon- The use of ultrasonic instrumentation during periradic-
tic surgeon must be well versed in both root morphol- ular surgery was first reported by Richman in 1957
ogy and root canal system anatomy. The teeth that when he used an ultrasonic chisel to remove bone and
Figure 12-37 Comparison between bur and ultrasonic root-end preparations. A, Bur preparation shows large cavity prepared obliquely to
the canal with a No. 3312 inverted cone bur. B, Ultrasonic preparation shows clean preparation parallel to the canal. Scanning electron micro-
graph. (Courtesy of Dr. Gary Wuchenich and Dr. Debra Meadows.)
cavities that followed the direction or the root canal Their data also indicated that more dentin cracks
more closely than those prepared with a bur 161,162 (see occurred when the ultrasonic tip was used on the high-
Figure 12-37, B). frequency setting than on the low-frequency setting
A recent controversy has developed regarding the and that more cracks resulted following ultrasonic
potential for ultrasonic energy in root-end cavity root-end cavity preparation, regardless of the frequen-
preparation to result in the formation of cracks in the cy setting, than after root-end resection alone.167
dentin surrounding the root-end preparation. Some Calzonetti and associates used a polyvinylsiloxane
authors have reported that the use of ultrasonic instru- replication technique to study cracking after root-end
mentation resulted in an increased number and extent resection and ultrasonic root-end preparation in
of dentin crack formation.163,164 Others have reported cadavers teeth. They found no cracks in 52 prepared
no difference in the incidence of dentin crack forma- root-ends examined under scanning electron
tion between bur and ultrasonic root-end cavity prepa- microscopy.168 Their results indicate that there is a pos-
ration in extracted teeth.165,166 sibility that the intact periodontal ligament adds a pro-
Layton and associates reported an in vitro study tective function by absorbing the shock of ultrasonic
evaluating the integrity of the resected root-end sur- vibrations to prevent cracking in the clinical setting, a
faces, following root-end resection and after root-end possibility that was not observed in extracted human
preparation, with ultrasonic instrumentation at low teeth studies.
and high frequencies. The results indicated that root- Morgan and Marshall reported on an in vivo study
end resection alone may result in dentin crack forma- using electron microscopy to examine resin casts made
tion regardless of the type of root-end preparation. from polyvinylsiloxane impressions taken following
root-end resection and root-end preparation with In vitro cytotoxicity and biocompatibility studies
ultrasonic instrumentation at low power setting. Their using cell cultures have also been published. Owadally
results revealed that no cracks were evident on any of and associates reported on an in vitro antibacterial and
the roots following root-end resection alone and only cytotoxicity study comparing IRM and amalgam. Their
one small, shallow, incomplete crack was detected from results indicated that IRM was significantly more anti-
25 roots following ultrasonic root-end preparation.169 bacterial than amalgam at all time periods of exposure,
Sumi and associates reported on a human clinical and amalgam was significantly more cytotoxic than
outcomes assessment study that evaluated the suc- IRM.173 Makkawy and associates evaluated the cyto-
cess/failure rate of periradicular surgeries performed toxicity of resin-reinforced glass ionomer cements
on 157 teeth involving root-end cavity preparations compared with amalgam using human periodontal lig-
using ultrasonic instrumentation. Observation periods ament cells. Their results indicated that, at 24 hours,
ranged from 6 months to 3 years. Outcome assessment amalgam significantly inhibited cell viability compared
was based on clinical and radiographic findings. A suc- with resin-reinforced glass ionomer cement and the
cess rate of 92.4% was reported. It was concluded that controls. At 48 and 72 hours, however, all materials
ultrasonic root-end preparation provides excellent tested exhibited a similar slightly inhibitory effect on
clinical results.170 Available evidence indicates that cell viability.174
root-end cavity preparation using ultrasonic instru- Chong and associates compared the cytotoxicity of a
mentation provides a convenient, effective, and clini- glass ionomer cement (Vitrebond; 3M Dental; St Paul,
cally acceptable method for preparing the resected Minn.), Kalzinol, IRM and EBA cements, and amalgam.
root end to receive a root-end filling. Their results indicated that fresh IRM cement exhibited
the most pronounced cytotoxic effect of all materials
Root-End Filling tested. Aged Kalzinol was the second most cytotoxic
The purpose of a root-end filling is to establish a seal material, with no significant difference being reported
between the root canal space and the periapical tissues. between Vitrebond EBA cement and amalgam.175
According to Gartner and Dorn, a suitable root-end fill- Zhu, Safavi, and Spangberg evaluated the cytotoxic-
ing material should be (1) able to prevent leakage of bac- ity of amalgam, IRM cement, and Super-EBA cement
teria and their by-products into the periradicular tissues, in cultures of human periodontal ligament cells and
(2) nontoxic, (3) noncarcinogenic, (4) biocompatible human osteoblast-like cells. Their results indicated that
with the host tissues, (5) insoluble in tissue fluids, (6) amalgam was the most cytotoxic of the materials tested
dimensionally stable, (7) unaffected by moisture during and showed a reduction in total cell numbers for both
setting, (8) easy to use, and (9) radiopaque.171 One cell types. IRM and Super-EBA, however, were signifi-
might add, it should not stain tissue (tattoo). cantly less cytotoxic than amalgam and demonstrated
Root-End Filling Materials. Numerous materials no reduction in total cell numbers for both periodon-
have been suggested for use as root-end fillings, includ- tal ligament and osteoblast-like cells.176
ing gutta-percha, amalgam, Cavit, intermediate restora- Several authors have published results of in vivo tis-
tive material (IRM), Super EBA, glass ionomers, com- sue compatibility studies of various root-end filling
posite resins, carboxylate cements, zinc phosphate materials using an experimental animal model.
cements, zinc oxideeugenol cements, and mineral tri- Harrison and Johnson reported on a study designed to
oxide aggregate (MTA). The suitability of these various determine the excisional wound-healing responses of
materials has been tested by evaluating their microleak- the periradicular tissues to IRM, amalgam, and gutta-
age (dye, radioisotope, bacterial penetration, fluid filtra- percha using a dog model. Healing responses were eval-
tion), marginal adaptation, and cytotoxicity and clinical- uated microscopically and radiographically at 10 and
ly testing them in experimental animals and humans. 45 days postsurgically. They reported no evidence of
A large number of in vitro studies dealing with the inhibition of dentoalveolar or osseous wound healing
marginal adaptation and sealing ability (leakage) of associated with amalgam, gutta-percha, or IRM.
various root-end filling material have been published. Statistical analysis showed no difference in wound
The results of these studies have often been inconsis- healing among the three materials tested.177
tent, contradictory, and confusing and have been ques- Pitt Ford and associates examined the effects of
tioned as to their clinical relevance. Factors such as the IRM, Super-EBA, and amalgam as root-end filling
choice of storage solutions and the molecular size of materials in the roots of mandibular molars of mon-
the dye particles, and many other variables, can cru- keys. They reported that the tissue response to IRM and
cially influence the outcome of these in vitro studies.172 Super-EBA was less severe than that to amalgam. No
inflammation was evident in the bone marrow spaces has also been shown to be less cytotoxic than amalgam,
adjacent to root-end fillings of IRM and Super-EBA. In IRM, or Super-EBA. Animal usage tests in which MTA
contrast, however, inflammation was present in the and other commonly used root-end filling material
alveolar bone marrow spaces with every root end filled were compared have resulted in less observed inflam-
with amalgam.178,179 mation and better healing with MTA. In addition, with
A research group at Kyushu University in Japan MTA, new cementum was observed being deposited on
reported the results of a histologic study comparing the the surface of the material183194 (Figure 12-41).
effects of various root-end filling materials, including a Many prospective and retrospective human clinical
4-META-TBB resin (C&B Metabond, Parkell, usage studies have been reported that assess the out-
Farmingdale, N.Y.), using a rat model. The materials come of periradicular surgery involving the placement
tested were amalgam, light-cured glass ionomer of various root-end filling materials. It is difficult to
cement, IRM, a 4-META-TBB resin, and light-cured compare the results of these studies because the
composite resin. The 4-META-TBB resin and light- authors have used differing evaluation criteria and
cured composite resin root-end fillings showed the observations periods. It is important, however, to con-
most favorable histologic response among the materi- sider some of the more significant of these clinical
als tested. These materials did not provoke inflamma- usage reports.
tion and did not appear to inhibit new bone formation, Oynick and Oynick, in 1978, reported on the clinical
as seen with the other materials.180 use of a resin and silicone-reinforced zinc oxide and
Torabinejad and associates reported on a study eugenol cement (Stailine, Staines, England) as a root-
designed to examine and compare the tissue reaction to end filling material in 200 cases over a period of 14
several commonly used root-end filling material and a years. Radiographic evaluations following periradicu-
newly developed material, MTA (ProRoot, Tulsa lar surgical procedures using Stailine indicated favor-
Dental/Dentsply International; Tulsa, Okla.). Their study able healing. Histologic and SEM evaluations of the
involved the implantation of amalgam, IRM, Super-EBA, root apex and adjacent periradicular bone, taken by
and MTA in the tibias and mandibles of guinea pigs. The block section, revealed newly formed bone in areas of
presence of inflammation, predominant cell type, and previous resorption and collagen fibers growing into
thickness of fibrous connective tissue adjacent to each the filling material.195
implanted material was evaluated. The tissue reaction to Dorn and Gartner reported on a retrospective study
implanted MTA was the most favorable observed at both of 488 periradicular surgical treatments in which three
implantation sites; in every specimen, it was free of inflam- different root-end filling materials were used, IRM,
mation. Mineral trioxide aggregate was also the material Super-EBA, and amalgam. The evaluation period was
most often observed with direct bone apposition.181 from 6 months to 10 years. Outcome assessment was
Mineral trioxide aggregate was developed by conducted by evaluation of the most recent recall radi-
Torabinejad and his associates at Loma Linda University.
The main molecules present in MTA are calcium and
phosphorous ions, derived primarily from tricalcium sil-
icate, tricalcium aluminate, tricalcium oxide, and silicate
oxide. Its pH, when set, is 12.5 and its setting time is 2
hours and 45 minutes. The compressive strength of MTA
is reported to be 40 MPa immediately after setting and
increases to 70 MPa after 21 days. The result of solubili-
ty testing of MTA (ADA specification #30) indicated an
insignificant weight loss following testing.182
Mineral trioxide aggregate has been extensively eval-
uated for microleakage (dye penetration, fluid filtration,
bacterial leakage), marginal adaptation (SEM), and bio-
compatibility (cytotoxicity, tissue implantation, and in
vivo animal histology). The sealing ability of MTA has
been shown to be superior to that of Super-EBA and
Figure 12-41 Mineral trioxide aggregate (MTA) retrofilling.
was not adversely affected by blood contamination. Its Cementum (arrow) formed subjacent to the filling material (sepa-
marginal adaptation was shown to be better than amal- rated from the material during slide preparation). B = bone; D =
gam, IRM, or Super-EBA. Mineral trioxide aggregate dentin; RC = root canal. (Courtesy of Dr. M. Torabinejad.)
ograph as compared with the immediate postsurgical Barkhordar and Russel reported on an in vitro study
radiograph. Analysis of the data indicated there was no that examined the effect of irrigation with doxycycline
significant difference in the outcome of healing rates hydrochloride, a hydroxy derivative of tetracycline, on
between IRM and Super-EBA. There was a significant the sealing ability of IRM and amalgam, when used as
difference, however, in the outcome between IRM, root-end fillings. Their results indicated significantly
Super-EBA, and amalgam, the latter being the worst.196 less microleakage following irrigation with doxycycline
Pantschev and associates, however, reported on a involving both IRM and amalgam, compared with the
prospective clinical study that evaluated the outcome of control irrigation with saline. They also suggested that,
periradicular surgical procedures using either EBA because of the long-lasting sustentative of doxycycline
cement or amalgam. The minimum evaluation period on root surfaces and its slow release in a biologically
was 3 years and healing was based on clinical and radi- active state, their results support its use for dentin con-
ographic analysis. Their data indicated no significant ditioning before placement of a root-end filling in peri-
difference in the outcome between the two materials radicular surgery.209
evaluated.197 Based on a review of the currently available litera-
Rud and associates have reported on several prospec- ture, there does not appear to be an ideal root-end
tive and retrospective human usage studies in an attempt filling material. Intermediate restorative material,
to evaluate the acceptability of a composite resin, com- Super-EBA, and MTA appear to be the currently avail-
bined with a dentin bonding agent, as a root-end filling able materials that most closely meet the requirements,
material. The placement is different from other root-end both physical and biologic, for a root-end filling mate-
fillings in that no root-end preparation, other than root- rial. MTA is a relatively new material, compared with
end resection, is made. The material covers the entire IRM and Super-EBA, and long-term human usage
resected root-end surface. They have shown that the cre- studies are as yet not available for any of these materi-
ation of a leak-resistant seal is possible with this materi- als. Final judgment on their use will need to be reserved
al; however, the process is very technique sensitive as a until such clinical usage studies are available.
result of the need for strict moisture control. They have Placement and Finishing of Root-end Fillings.
reported complete bone healing in 80 to 92% of cases The method for placement of the root-end filling mate-
using this technique. Their observation periods ranged rial will vary depending on the type of filling material
from 1 to 9 years.198202 used. Amalgam may be carried to the root-end prepa-
Smear Layer Removal. Instrumentation of dentin ration with a small K-G carrier that is sized for root-
results in the accumulation of a smear layer covering end preparations. Deeper lying apices may be more
the dentinal surface and occluding the dentinal tubules. easily reached by using a Messing gun (Figure 12-42).
It has been shown that bacteria may colonize in the Zinc oxideeugenol cements (IRM and Super-EBA) are
smear layer and penetrate the dentinal tubules.203 best mixed to a thick clay-like consistency, shaped into a
Removal of this smear layer seems desirable in the sit- small cone, and attached to the back side of a spoon exca-
uation of root-end fillings that are placed in a bacteri- vator or the tip of a plastic instrument or Hollenback
ally contaminated root apex. Irrigation with tetracy- carver and placed into the root-end preparation.
cline has been shown to remove the smear layer.204
Smear layer removal from resected root ends and
dentin demineralization by citric acid has been shown
to be associated with more rapid healing and deposi-
tion of cementum on the resected root-end.205
Tetracyclines have a number of properties of interest
to endodontists; they are antimicrobial agents, effective
against periodontal pathogens; they bind strongly to
dentin; and when released they are still biologically
active.206 Root surfaces exposed to anaerobic bacteria
accumulate endotoxin and exhibit collagen loss, which
may suppress fibroblast migration and proliferation,
thus interfering with healing.207 Root surface condi-
tioning with acidic agents, such as tetracycline, not
only removes the smear layer, it also removes endotox- Figure 12-42 Root-end filling material carriers. Top, Messing gun
in from contaminated root surfaces.208 with a curved tip. Bottom, Small K-G carrier.
A B
C D
Figure 12-46 Various suture materials. A, Dexon II (braided absorbable polyglycolic acid) suture. B, Silk (braided nonabsorbable) suture.
C, Vicryl (braided absorbable polyglactin 910) suture. D, API (absorbable chromic gut) suture.
formaldehyde to increase its strength and is then Collagen. Reconstituted collagen sutures are made
shaped into the appropriate monofilament size. Gut from bovine tendon after it has been treated with
sutures are absorbable; however, the absorption rate is cyanoacetic acid and then coagulated with acetone and
variable and can take up to 10 days. Because of the dried. Collagen sutures offer no advantage over gut for
unpredictability of gut suture absorption in oral tis- endodontic surgery since their absorption rate and tis-
sues, a scheduled suture removal appointment should sue response are similar. They are available only in
be made. small sizes and used almost exclusively in microsurgery.
Chromic gut sutures consist of plain gut that has Polyglycolic Acid (PGA). Suture material made from
been treated with chromium trioxide. This results in a fibers of polymerized glycolic acid is absorbable in mam-
delay in the absorption rate. Because retention of malian tissue. The rate of absorption is about 16 to 20
sutures beyond a few days is not recommended in days. Polyglycolic acid sutures consist of multiple fila-
endodontic surgery, the use of chromic gut sutures ments that are braided and share handling characteristics
offers no advantage. Also, evidence indicates that plain similar to silk. Polyglycolic acid was the first synthetic
gut is more biocompatible with oral soft tissues than is absorbable suture and it is manufactured as Dexon.
chromic gut.2,219221 Polyglactin (PG). In 1975, Craig and coworkers
Gut suture material is marketed in sterile packets reported the development of a copolymer of lactic acid
containing isopropyl alcohol. When removed from the and glycolic acid called polyglactin 910 (90 parts glycol-
packet, the suture is hard and nonpliable because of its ic acid and 10 parts lactic acid).224 Sutures of polyglactin
dehydration. Before using, gut sutures should be are absorbable and consist of braided multiple filaments.
hydrated by placing them into sterile, distilled water for Their absorption rate is similar to that of polyglycolic
3 to 5 minutes. After hydration, the gut suture material acid. They are commercially available as Vicryl.
will be smooth and pliable with manipulative proper- Many studies have been reported evaluating the
ties similar to silk.223 response of the oral soft tissues to gut, collagen,
Figure 12-48 Suturing technique. A, Damp 2-inch 2-inch gauze is used to smooth tissue flap into place. B, Most unattached portion of
the flap is sutured to attached tissue. Two- to three-millimeter margin should be present between puncture points and incision lines.
C, Wound edges are approximated with the first tie. D, Surgeons knot is used to tie suture in place. E, Interrupted sutures are used to secure
remainder of flap.
After the suture needle has been passed through the secure and stabilize the horizontal component of full
mucoperiosteum on both sides of the incision, the mucoperiosteal flaps. The surgical needle is inserted
suture material should be drawn through the tissue through the buccal or facial interdental papillae, then
until the end opposite the needle is approximately 1 to through the lingual interdental papillae, and then back
2 inches from the tissue. The suture should be tied with through the interdental embrasure. It is tied on the
a secure knot. A surgical knot is the most effective and buccal or facial surface of the attached gingiva (Figure
least likely to slip. The surgeons knot is best tied by 12-49, A). This suture technique highly predisposes the
wrapping double loops or throws of the long end (the fragile interdental tissue and col to inflammation and
end with the needle attached) of the suture around the retarded healing, resulting in a loss of the outer gingi-
needle holder. By then grasping the short end of the val epithelium, with possible blunting or formation of
suture with the needle holder and slipping the throws a double papillae.
off, the first half of the surgical knot is tied. After A modification of this interrupted loop suture is
adjusting the tissue tension, the second half of the knot described as follows. After the surgical needle has been
is tied by repeating the same process, except wrapping passed through the buccal and lingual papillary gingi-
the loops of suture around the needle holder in the va, the suture is passed over the interdental contact and
opposite direction from the first tie, like a square knot. secured with a surgeons knot. This modification elim-
Suture knots should be placed to the side of the inci- inates the presence of suture material in the interdental
sion. Suture knots collect food, plaque, and bacteria, embrasure, thus reducing postsurgical inflammation to
thus resulting in localized infection and a delay in heal- this delicate tissue. In clinical situations in which the
ing when placed directly over the incision (Figure 12- horizontal component of a full mucoperiosteal flap
48, C and D). involves a tooth or teeth with full-coverage crowns, this
Interrupted Loop (Interdental) Suture. The inter- modification allows for a slight incisal or occlusal repo-
rupted loop, or interdental suture, is used primarily to sitioning of the mucoperiosteal flap. This can be
their early removal.2 The primary purpose for placing discomfort associated with the placement of the scis-
sutures following endodontic surgery is to approximate sors blade under the suture, a procedure that is partic-
the edges of the incisional wound and to provide stabi- ularly painful in areas of persistent swelling and edema,
lization until the epithelium and myofibroblast commonly seen in the mucobuccal fold.
fibronectin network provides a sufficient barrier to dis- Sharp-pointed scissors are used to cut the suture
lodgment of the flapped tissues. This usually occurs material, followed by grasping the knotted portion
within 48 hours following surgery. It has been recom- with cotton pliers and removing the suture. Various
mended that sutures should not be allowed to remain designs of scissors are available and can be selected
longer than 96 hours. according to specific access needs in different areas of
A suture removal kit should contain a cotton swab, the mouth. It has been suggested that a No. 12 scalpel
2-inch 2-inch gauze sponges, suture scissors, cotton blade be used to sever the suture. The advantages are
pliers, and a mouth mirror (Figure 12-55). The sutures stated to be a predictably sharp cutting edge and less
and surrounding mucosa should be cleaned with a cot- tug on the suture.232
ton swab containing a mild disinfectant followed by
hydrogen peroxide. This helps to destroy bacteria and Corrective Surgery
remove plaque and debris that have accumulated on Corrective surgery is categorized as surgery involving
the sutures, thus reducing the inoculation of bacteria the correction of defects in the body of the root other
into the underlying tissues as the suture is pulled than the apex. When the coronal and middle thirds of
through. A topical anesthetic should also be applied the root are involved, it is imperative to physically
with a swab at the surgical site. This greatly reduces the observe, diagnose, and repair the defect. A full sulcular
mucoperiosteal flap, such as the triangular or rectangu-
lar design, must be used to gain adequate visual and
surgical access. Corrective surgical procedures may be
necessary as a result of procedural accidents, resorption
(internal or external), root caries, root fracture, and
periodontal disease. Corrective surgery may involve
periradicular surgery, root resection (removal of an
entire root from a multirooted tooth leaving the clini-
cal crown intact), hemisection (the separation of a
multirooted tooth and the removal of a root and the
associated portion of the clinical crown), or intention-
al replantation (extraction and replantation of the
tooth into its alveolus after the corrective procedure has
been done). Reparative defects of the root and associat-
ed procedures are classified as follows:
I. Perforation repair
A. Mechanical
B. Resorptive/caries
A B C
Figure 12-56 A, Lateral midroot perforation with extruded filling material. B, Radiograph following surgical removal of extruded filling
material, root-end resection, root-end fill, and repair of perforation defect with mineral trioxide aggregate (MTA). C, Radiograph 2 years fol-
lowing surgery.
attempt at correction should be an internal repair (see managed by intentional replantation, root resection, or
chapter 14, Endodontic Mishaps: Their Detection, hemisection.
Correction, and Prevention). Corrective surgery should Midroot perforations, such as those resulting from
be reserved for those teeth when internal repair is not a postspace preparations, should be immediately sealed
treatment option or when internal repair has failed. internally, if possible, or calcium hydroxide should be
Strip perforations that occur on the distal aspect placed as an intracanal dressing and sealed at a subse-
of the mesial roots of maxillary and mandibular molars quent appointment. If the perforation is excessively
are usually inaccessible and extremely difficult to repair large or long-standing, a full mucoperiosteal flap
surgically. Visual and surgical access is limited, and should be reflected, the perforation site identified, and
bone removal necessary to obtain access to the site of the repair made with an appropriate repair material
the perforation usually results in a major periodontal (Figure 12-56). If the perforation is located in the api-
defect. This type of clinical situation may be better cal third of the root, a root-end resection, extending to
A B
Figure 12-57 A, Lateral perforation of the apical one-third of the mesial root of tooth No. 31. B, Root-end resection of mesial root. Root
canal was obturated with mineral trioxide aggregate (MTA).
the point of the perforation, and a root-end filling If the resorptive defect opens into the gingival sulcus
should be considered as a more effective and efficient on the lingual or palatal surface of the tooth, surgical and
way of handling this clinical situation (Figure 12-57). visual access are much more difficult. A sulcular lingual
Resorption (External or Internal) and Root Caries. or palatal flap can be raised to explore the extent of the
Repair of a defect on the root surface, from either inter- defect. Vertical incisions on the lingual side of the
nal or external resorption, depends to a large extent on mandible should be avoided whenever possible because
whether there is communication between the resorp- of the fragile nature of this tissue. If the resorptive defect
tive defect and the oral cavity and/or the pulp space. is surgically accessible, treatment can proceed as
When communication between the defect and the oral described earlier. If it is not accessible, then intentional
cavity exists, a corrective surgical procedure is usually replantation or extraction should be considered.
necessary. When the resorptive defect has also commu- Some cases of resorption or root caries are so exten-
nicated with the pulp space, excessive and persistent sive that nothing can be done to save the entire tooth.
hemorrhage into the pulp space is usually evident dur- Extraction may be the solution for some cases, or total
ing root canal instrumentation. This makes cleaning, root amputation or hemisection may apply to others. A
shaping, and obturation of the pulp space very diffi- case in point calling for hemisection is illustrated in
cult, unless surgical repair of the resorptive defect is Figure 12-59. Internalexternal resorption has
done first. If the decision is made to repair the root destroyed virtually one half of a lower first molar, a ter-
defect before filling the pulp space, after the pulp tissue minal tooth in the arch, with opposing occlusion.
has been removed, a temporary, easily removable fill- Probing with a cowhorn explorer and viewing the radi-
ing should be placed in the root canal space. A large ograph reveals the massive lesion and defect (Figure 12-
gutta-percha point may be used for this purpose; no 59, A and B). The crown of the tooth is sectioned buc-
sealer is used. This will serve as an internal matrix to colingually with a high-speed fissure bur (Figure 12-59,
prevent the repair material from obstructing the root CE). The mesial crown and root are then extracted,
canal. Depending on the setting time of the repair and immediate root canal therapy is completed in the
material used, the pulp space may be prepared and remaining distal root (Figure 12-59, F and G). A pre-
obturated at the same appointment. Otherwise, an molar rubber dam clamp may be used on the remaining
intracanal dressing of calcium hydroxide should be bicuspidized distal root of the molar. The remaining
placed, the access cavity sealed from oral contamina- tooth structure and edentulous space should be restored
tion, and the pulp space prepared and obturated at a with a fixed partial denture as soon as possible to pre-
subsequent appointment (Figure 12-58). vent mesial drift of the distal root (Figure 12-59, H).
In the case of a resorptive defect that opens into the This provides for function against the maxillary oppo-
gingival sulcus, the approach depends to a great extent nent(s), thereby preventing continual eruption.
on the location and the extent of the defect. If it is Periodontal Repair. Guided Tissue (Bone)
approachable from the buccal or facial side, a full Regeneration. In the past, extensive periodontal defects
mucoperiosteal flap should be raised, and the extent of required extraction or root amputation. Today, with
the defect established. If the resorptive defect has not techniques of guided bone regeneration and demineral-
extended into the pulp space, it should be restored ized freeze-dried bone allografts, many teeth that were
with a suitable material, such as amalgam, composite previously untreatable can be saved. Several authors
resin, or glass ionomer cement. If the defect has have published reports on the effectiveness of the use
extended into the pulp space, the flap should be repo- calcium sulfate, alone and as a composite with an allo-
sitioned and stabilized with a suture. A rubber dam graft material, and resorbable and nonresorbable barrier
should be placed and a conventional coronal access membranes, with and without allografts, on the quality
preparation followed by removal of the pulp tissue and and quantity of alveolar bone regeneration in endodon-
placement of a temporary internal matrix should be tic and periodontic defects. Many of these case reports
done. Following this, the rubber dam should be have had mixed results.233238
removed, the flap elevated, the resorptive defect Few controlled clinical studies comparing the results
repaired, and the flap repositioned and stabilized with of the use of guided bone regeneration techniques have
sutures. The temporary internal canal matrix should been reported. Santamaria and associates reported on a
be removed and the root canal preparation and obtu- controlled clinical study to determine the degree of
ration completed or a calcium hydroxide intracanal bone regeneration following radicular cyst enucleation.
dressing placed and the endodontic treatment com- Thirty patients were involved in the study. The control
pleted at a subsequent appointment. group consisted of enucleation of the cyst only and the
A B
C D
E F
G H
Figure 12-58 Corrective surgical repair of root-resorptive defect. A, Constant drainage mesial to first premolar bridge abutment. Internal
and external resorption revealed in radiograph. B, Elevating rectangular flap uncovers huge dehiscence and resorptive defect Instrument
placed into defect proves connection with pulp lesion. C, Conventional occlusal endodontic cavity is prepared and pulpectomy is performed.
Internal matrix of endodontic silver point is placed. D, Internal matrix in place and hemorrhage controlled. E, Amalgam filling inserted into
external resorptive defect. Non-zinc alloy is used. F, Silver point is immediately removed and flap repositioned and sutured. Because of time
constraints in this particular case, canal enlargement and obliteration are completed at subsequent appointment. G, Radiograph 9 months
following therapy. Repair of bone is apparent. H, Photograph 9 months following therapy. Note complete repair of draining stoma and inci-
sions. (Courtesy of Dr. David Yankowitz.)
A B
C D
E F
G H
Figure 12-59 Technique for hemisecting and restoring mandibular molar. A, Using cowhorn explorer, resorptive lesion and relation to crest
of alveolar process are established. B, Huge area of internal resorption involving mesial half of molar. C, Extra long #559-XL fissure bur has
length or reach necessary to cut entirely through crown to furca. D, Tooth is sectioned from buccal to lingual with copious water and aspi-
ration. E, Sectioning completed. Base of cut must terminate at alveolar crest. F, Hemisected mandibular molar. Pathologic mesial half is ready
for extraction. Accuracy of sectioning is shown by radiograph. G, Care must be exercised not to gouge remaining distal portion. Root canal
therapy is completed at same dental appointment. Teeth are ready for immediate restoration. H, Importance of restoration for contact with
opposite arch is here demonstrated. (Restoration by Dr. Milan V. Starks.)
experimental groups involved enucleation of the cyst 2. Destruction of a root through resorptive processes,
plus the use of either a resorbable or nonresorbable caries, or mechanical perforations.
membrane. The residual volume and density of the 3. Surgically inoperable roots that are calcified, contain
newly formed tissue were measured by computer-assist- separated instruments, or are grossly curved.
ed tomography and computer-assisted digital image 4. The fracture of one root that does not involve the
analysis before and after enucleation. No statistically other.
significant difference was noted in the volume or densi- 5. Conditions that indicate the surgery will be techni-
ty of the newly formed tissue between the three treat- cally feasible to perform and the prognosis is rea-
ment groups 6 months postsurgically. The results sug- sonable.
gested that guided bone regeneration using membranes
does not contribute to increased quality or quantity of CONTRAINDICATIONS FOR ROOT AMPUTATIONS:
bone regeneration in this clinical situation.239 1. Lack of necessary osseous support for the remaining
Pecora and associates reported on a controlled clinical
root or roots.
study involving 20 patients with large endodontic bony
2. Fused roots or roots in unfavorable proximity to
lesions that failed to respond to nonsurgical endodontic
each other.
treatment. Following curettement of the lesions, 10 sites
3. Remaining root or roots endodontically inoperable.
were covered with Gortex membranes before reposition-
4. Lack of patient motivation to properly perform
ing the flap, and 10 were left uncovered. The investiga-
home-care procedures.
tors reported that radiographic analysis of the lesions 12
months postsurgically revealed that the quality and MORPHOLOGIC FACTORS: The length, width, and
quantity of the regenerated bone were superior when the contour of the roots are important factors in determin-
Gortex membranes were used.240 ing where the resective cut is made and the strength of
Root Amputation. Root amputation procedures are the remaining tooth structure. It is important to be
a logical way to eliminate a weak, diseased root to allow aware of the normal and varied anatomy that may be
the stronger root(s) to survive when, if retained togeth- encountered as these factors will materially affect the
er, they would collectively fail. Selected root removal procedures of root separation and removal. A careful
allows improved access for home care and plaque con- check of the radiograph and probing of periodontal
trol with resultant bone formation and reduced pocket pockets will help to reveal tooth-to-tooth and root-to-
depth. The incorporation of one half or two-thirds of a root proximities, as well as morphologic characteris-
tooth can be instrumental in obviating the need for a tics, such as root size and curvature, furcal location,
long-span fixed partial or a removable partial denture. and fused roots (Figure 12-60).
Quite often, amputation of a hopelessly involved root Two different approaches to resection are available.
of an abutment tooth saves an entire fixed prosthesis, One approach is to amputate horizontally or obliquely
even one that is full arch in extent. the involved root at the point where it joins the crown,
As always, case selection is an important factor in a process termed root amputation (Figure 12-61). The
success. Proper diagnosis, treatment planning, case other approach is to cut vertically the entire tooth in
presentation, and good restorative procedures are all halffrom mesial to distal of the crown in the maxil-
critical factors equally important to the resective proce- lary molars, and from buccal to lingual of the crown in
dure itself. The strategic value of the tooth involved the mandibular molarsremoving in either case the
must be convincing. pathologic root and its associated portion of the crown.
Evaluation of the involved tooth requires thorough This procedure is termed hemisection (Figure 12-62).
periodontal evaluation of the root or roots to be Bisection or bicuspidization refers to a division of
retained. Remaining structures need continuing peri- the crown that leaves the two halves and their respec-
odontal care, and this should be pointed out to the tive roots. This bisection is designed to form a more
patient. Bony support, the crownroot ratio, occlusal favorable position for the remaining segments that
relations, and restorability of the remaining segment all leaves them easier to clean and maintain (Figure 12-
determine the case outcome. 63). If the remaining roots are too close to each other,
minor orthodontic movement may be necessary to
INDICATIONS FOR ROOT AMPUTATION:
properly align them. The careful preparation and
1. Existence of periodontal bone loss to the extent that restoration of the remaining portions of the tooth to
periodontal therapy and patient maintenance do not minimize food entrapment and plaque accumulation
sufficiently improve the condition. are critical to the long-term success in this situation.
A B
Figure 12-61 A, Periradicular lesion consistent with possible ver-
tical root fracture. B, Mesiobuccal root amputation due to vertical
root fracture. C, Clinical crown restored with porcelain-fused-to-
metal prosthetic crown.
A B
Figure 12-62 A, Postspace perforation on distal aspect of mandibular first molar resulting in a periodontal defect. B, Hemisection and dis-
tal root amputation. Note the molars have been splinted together.
and vertical resections through the crown and the furca- To resect a root involving a tooth that is an abutment
tion. Kirchoff and Gerstein suggested reshaping the for a fixed partial denture or has previously been
crown with a bur so that the crown structure over the crowned and a new restoration has not been planned,
root to be removed is resected along with the root. This the endodontic surgeon must do the resection horizon-
simplifies the task by making the root-furcation junction tally or at an oblique angle. The more vertical the resec-
more visible for separation and extraction.241 tive cut, the greater the ease of maintaining cleanliness.
Care must be exercised in maintaining the correct a small round brush (Figure 12-65). The patient should
angulation of the bur to avoid gouging the remaining be instructed in its use and monitored postsurgically
root or crown. for proper effectiveness.
When the root to be removed has been completely AMPUTATION TECHNIQUE FOR MANDIBULAR MOLARS:
resected, there may be enough loss of periradicular Treatment planning is critical when evaluating
bone to permit it to be lifted or elevated from the sock- mandibular molars for root amputation. If the tooth is
et (Figure 12-64). It is possible, however, that sufficient not a terminal tooth in the arch or an abutment for a
periradicular bone and cortical plate remain such that fixed partial denture, extraction and replacement may
reflecting a mucoperiosteal flap is necessary so that suf- be a preferred treatment. Some outstanding successes,
ficient bone can be removed to facilitate root removal. however, are seen involving hemisection and placement
Elevation of a flap also allows for osseous recontouring. of a three-unit fixed partial denture (see Figure 12-68).
Recontouring of the crown at the point of resection The most common method of root amputation
is very important. Plain fissure burs and tapered dia- involving mandibular molar teeth is a hemisection. A
mond stones are ideal for this reshaping process. The terminal second mandibular molar is ideally suited for
junction of the crown with the furcation should be hemisection, provided there is opposing occlusion and
smooth, with a gradual taper toward the interdental adequate bone support for the remaining root (Figure
embrasure. There should not be any semblance of a 12-66). The remaining root and crown structure is
stump left, and enough clearance between the under- restored as a premolar.
surface of the crown and the tissue should be estab- The root to be retained undergoes endodontic ther-
lished to facilitate good oral hygiene. Following root apy. A post is placed in the retained root, if indicated,
amputation, oral hygiene can be enhanced by the use of or a coronalradicular core is placed. Following set of
A B
C D
Figure 12-64 Excellent example of bilateral oblique root amputation on the same patient. A, Right maxillary first molar before root canal
therapy and root amputation. Distobuccal root has lost its entire bony support. Because furca is exposed, flap need not be raised to ampu-
tate this root. B, Result 6 years after amputation. Occlusal table has been narrowed considerably. C, Left maxillary first molar in same patient
with bony housing of distobuccal root completely destroyed. D, Result 6 years following root canal therapy and amputation; patient is metic-
ulous in home care.
Figure 12-66 Terminal molar, hemisected and bicuspidized. A, Distal half of tooth removed. B, Final full crown restoration contacts both
adjacent and opposing molars.
A B
Figure 12-67 Mesial root amputation of a mandibular molar involving the distal abutment of a fixed partial denture. A, Root perforation
with root canal filling material and bone loss in the furcation. B, Radiograph taken 5 years following mesial root amputation.
bonding. A buccal/facial marginal mucoperiosteal flap Prevalence of these grooves may be higher than pre-
is raised, and the entire root is resected at a level well viously suspected. After examining 921 maxillary inci-
below the gingival margin. The remaining tooth struc- sors, Pecora and his associates in Sao Paulo reported a
ture should be contoured in a convex shape to resem- 2% incidence in central incisors and a 2.6% incidence
ble a pontic. The severed root should be removed to the in lateral incisors. Most of the central incisor grooves,
buccal side of the alveolar bone and the flap reposi- however, were found on the facial surface.252 Goon and
tioned and stabilized with appropriate sutures. his associates at the University of the Pacific in San
Several studies have evaluated the long-term success Francisco reported on an unusual facial radicular
of root-resected and hemisected teeth. The results groove in a maxillary lateral incisor.253
range from a success rate of 62 to 100% occurring over Robinson and Cooley have suggested a surgical
times ranging from 1 to 23 years. Combining the data intervention that may, in a number of cases, correct
from these studies indicates an overall success rate of the defect and allow healing.254 Following a palatal
88% for the time periods followed.242251 Long-term surgical exposure of the defect, the groove is eliminat-
prognosis of teeth with roots totally amputated or ed by grinding it away with round burs or diamond
hemisected depends on the quality of the original sur- points. Shallow grooves are handled differently from
gery and recontouring of the remaining tooth struc- deep grooves (Figure 12-69). If the lingual groove,
ture, on the quality of the root canal treatment in the however, is so deep that it communicates with the
remaining root or roots, on the quality of the final pulp space, the case is hopeless and extraction of the
restoration, on the quality and quantity of the remain- tooth is indicated.92
ing supporting bone, and on the status of periodontal
care. Any one, or combination, of these factors may REPLACEMENT SURGERY
cause failure of the case. When all of these elements are (EXTRACTION/REPLANTATION)
well executed, a superb and long-lasting result may be Grossman, in 1982, defined intentional replantation
achieved (Figure 12-68). as the act of deliberately removing a tooth andfol-
Surgical Correction of the Radicular Lingual Groove. lowing examination, diagnosis, endodontic manipu-
Another serious periodontal defect that can sometimes be lation, and repairreturning the tooth to its original
corrected surgically is the radicular lingual groove socket.255 Extraction/replantation is by no means a
(palatogingival groove). Found almost exclusively in max- recently developed procedure. Abulcasis, an Arabian
illary lateral and central incisors, this developmental physician practicing in the eleventh century, is the
defect in root formation precludes the deposition of first credited with recording the principle of extrac-
cementum in the groove; hence it prevents periodontal tion/replantation.256 Over the years since then, many
ligament (PDL) attachment. The groove then causes a authors have published reports of studies and case
narrow periodontal pocket, a bacterial pathway, often to reports dealing with the technique and results of
the root apex, that can lead to retroinfection of the pulp.92 extraction/replantation.257261
A B
C D
Figure 12-68 Hemisection of mandibular molar. A, Decision to hemisect molar and restore space relates to open contacts and future drifting. B,
Tooth is hemisected through furca, and pathologic root removed. Root canal filling of remaining distal root is done at the same appointment
through exposed pulp chamber. C, Final restoration of space converts first molar into a premolar. D, Forty-seven-year recall film attests to the
meticulous therapy and long-range efficacy of this case. (Endodontic therapy by Dr. Dudley Glick and restoration by Dr. James McPherson.)
A B
Figure 12-69 Surgical exposure of palatogingival groove allows saucerization with diamond stones or burs to remove pathologic groove.
A, Illustration of the chronic lesion (left) and saucerization to eliminate the lingual groove (right). The cross-section shows the contour of
the lingual surface with the groove (left) and after it has been removed. B, An acute lesion may result in less bone loss than a chronic lesion.
In this situation, it may be possible to eliminate the groove without flattening the entire lingual surface. The cross-section illustrates the con-
tour of the lingual surface as it might appear with the groove (left) and its contour after removal (right). Reproduced with permission from
Robison SF, Cooley RL. Gen Dent 1988;36:340.
mobility is achieved. This is a very crucial step in the required. If excessive mobility is evident, splinting is
extraction process as it helps to accomplish extrac- suggested. The recommended splinting type and
tion with the least chance of root fracture. length of time are the same as those for replantation
2. The appropriate forceps are chosen and preferably following traumatic avulsion and are discussed in
the beaks are wrapped with a sterile gauze sponge chapter 15, Endodontic Considerations in Dental
that is saturated with normal saline or Hanks Trauma. In the case of a posterior tooth, stabiliza-
Balanced Salt Solution. Every attempt should be tion may be achieved by placing a figure-8 suture
made to minimize damage to the cementum during over the occlusal surface of the tooth. The suture
the extraction process. may be secured on the occlusal surface of the tooth
3. Following extraction, the tooth should be held with by placing a shallow groove on the buccal-lingual
the forceps, protected by saturated gauze or by hand at aspect of the crown (Figure 12-70). Stabilization
the coronal portion using a saturated gauze. The roots may also be achieved by the use of a flexible wire
of the tooth should be thoroughly examined with with acid etching and bonding with composite resin
fiber-optic illumination and magnification to evaluate to an adjacent tooth (Figure 12-71).
for the presence of root fractures or radicular defects, 8. The patient should be seen 7 to 14 days following
such as perforations or resorptions. The application of intentional replantation surgery to remove any stabi-
methylene blue dye to the root surfaces may enhance lization that was placed and to evaluate tooth mobili-
visualization of otherwise nonvisible root defects. It is ty. Postsurgical evaluation is recommended at 2, 6,
extremely important that the root surfaces be con- and 12 months following surgery (Figure 12-72).
stantly bathed with either normal saline or Hanks
Balanced Salt Solution during the time the tooth is out Intentional replantation is not a completely pre-
of its socket. Intentional replantation is best done as a dictable procedure. Under favorable conditions, how-
team effort with each member of the team trained and ever, some authors have reported success rates in excess
skilled in their specific function. of 20 years.262268
4. If no root fractures are evident and the prognosis for
replantation appears positive, any root defects IMPLANT SURGERY
should be repaired with an appropriate material. If Two types of endosteal implants fall under the purview
root end resection is indicated, it should be done of endodontics: endodontic implants and osseointe-
with a plain fissure bur in a high-speed handpiece grated implants, also called endosseous implants.92
under constant irrigation. Two to three millimeters This is not to say that every dentist, or endodontist for
of root-end should be resected. A small class I root- that matter, should be placing endosteal implants,
end preparation should be done with either a bur or especially when the supporting alveolar bone is com-
an ultrasonic tip extending at least 3 mm into the promised. Only those who are specially trained and
root and an appropriate root-end filling placed. have extensive experience in periradicular and peri-
5. Following repair of any root defects and/or root-end odontal surgery should be involved in implant place-
resection and root-end filling, the extraction socket
should be irrigated with normal saline and gently suc-
tioned to remove any blood clot that may have
formed. The tooth is then carefully returned to its
socket. Reinsertion of the tooth into the socket may
be difficult at times, especially if there is a critical path
of insertion. Care must also be taken that the tooth is
returned to the socket in its proper orientation.
6. After the tooth has been inserted into the socket, a
rolled gauze sponge should be placed on the occlusal
aspect of the tooth and the patient instructed to bite
down so that the interocclusal force will seat the
tooth into its socket. The patient should be instruct-
ed to maintain interocclusal pressure for approxi-
mately 5 minutes.
7. In most cases, posterior teeth are well retained in Figure 12-70 Stabilization of the replanted tooth has been
their sockets and stabilization is usually not achieved by placing a suture over the occlusal surface.
A B
C D
Figure 12-72 A, Patient reported pain to pressure 1 year following root canal therapy, post and crown. Extraction/replantation chosen due
to proximity of mandibular canal. B, Radiograph 4 years following extraction/replantation procedure with intermediate restorative materi-
al (IRM) for root-end fillings. Patient is asymptomatic. C, Patient presented with pain and localized intraoral swelling, root canal therapy and
crown 20 years. D, Three years following extraction/replantation procedure. Silver point removed and root canal space filled with gutta per-
cha and sealer through retrograde approach.
which have proven quite successful (Figure 12-73). On surrounded the metal implant and separated it from the
the other hand, when too high a failure rate of alveolar bone274 (Figure 12-74).
endodontic implants developed, the profession backed Placing endodontic implants is a technique-sensi-
off from their use. Weine and Frank, however, retro- tive procedure. A perfectly round preparation must be
spectively revisited their endodontic implant cases reamed through the root apex and into the alveolar
placed over a 10-year period. While admitting to many bone. Failure to accomplish this task results in leakage
which did fail, they noted some remarkable long- around the implantdentin interface and eventual fail-
term successes with the technique.270 Their recom- ure of the implant (Figure 12-75). Another critical area
mendation was that endodontic implants not be dis- is structural weakening of the walls of the root as a
carded totally but used only in carefully selected cases. result of dentin removal in an attempt to create a
Orlay may have been among the first to use and advo- round apical orifice. This structural weakness may
cate endodontic implants.271 Frank is credited, however, result in root fracture either at the time of implant
with standardizing the technique, developing the proper placement or as a result of functional stresses on the
instruments, and matching implants.272, 273 Frank and tooth. It is also important that the periodontal condi-
Abrams were also able to show that a properly placed tion that has led to the periradicular bone loss has
endodontic implant was accepted by the periradicular been stabilized before endodontic implant placement.
tissue and that a narrow collar of healthy fibrous con- If not, the case will fail as a result of continued pro-
nective tissue, much like a circular periodontal ligament, gression of the periodontal disease.
Figure 12-74 A, Low-power photomicrograph of transverse section through subapical region of endodontic implant. Dark material at top
(arrow) is excess sealer. B, Higher power reveals connective tissue circular ligament configuration, without inflammation. Dark specks are
excess sealer being scavenged and resorbed. Reproduced with permission from Frank AL. J Am Dent Assoc 1969;78:520.
A B
C D
the conventional protocol: (1) the incorporation of two 1. Severity of the initial infection
procedures into one appointment, (2) the expediency of 2. Location of the root relative to the alveolus
total treatment time, and (3) the minimization of 3. Residual bone buccolingually and coronal apically
osseous collapse as well as resorption and maintenance 4. Vascularity of residual bone
of soft-tissue architecture. Immediate implant place- 5. Density of residual bone
ment, however, is not a universally applicable procedure. 6. Quality of cancellous marrow spaces
The presenting clinical situations may vary significantly. 7. Availability of bony walls to contain the bone-graft
According to Gelb, the variables that may affect the material
regenerative protocol include the following: 8. Volume of bone regeneration necessary
9. Soft tissue available for closure anterior teeth, for screw-retained prosthesis. For
10. Experience of the operator278 cement-retained anterior prostheses, the implant head
should be placed in line with the incisal edges of the
Gelb also stated, Despite these challenges, immedi- adjacent teeth. For cement-retained posterior prosthe-
ate implant surgery has been reported to have high pre- ses, the implant head should be placed slightly buccal
dictability, which compares favorably to outcome to the central fossa of the planned restoration.
reported in intact sites.278 In a study by Rosenquist Placement of the implant approximately 3 mm apical
and associates, 109 titanium threaded implants were to the cementoenamel junction of the adjacent teeth
placed immediately following extraction in 51 patients will ensure the maximum flexibility in the emergence
and evaluated over a mean observation time of 30 profile of the restoration.278
months. They reported a 92% survival rate for Bone Graft and Membrane Placement. Preserving
implants that replaced teeth extracted for periodontal and/or regenerating buccal or labial bone are important
reasons and a 96% survival rate for implants that to support soft-tissue dimensions and to give the
replaced teeth that were extracted for other reasons appearance of a root eminence. The use of bone-grafting
including endodontic treatment failure, root fracture, materials and membranes, resorbable and nonre-
and extensive caries.279 sorbable, may be used to promote bone growth around
Appropriate clinical situations for immediate the implant and to preserve or restore labial dimensions.
implant placement should have adequate bone apical Demineralized freeze-dried bone allograft is a common-
to the extraction socket and/or adequate bone buccol- ly used bone-graft material for this purpose.278
ingually to secure initial stability of the implant. The The bone-graft material is hydrated with sterile
apical dimension of bone should be a minimum of 3 to saline and packed into the void. Bone-graft material
4 mm in height and the buccolingual bone must be and a membrane are both used when there is a signifi-
evaluated on the basis of both quality and quantity. The cant defect or when narrowing of the labial dimension
presence of a localized infection does not generally pre- is of major concern. When the bony walls of the defect
clude immediate implant placement. Tooth removal are well defined and both cortical and cancellous
and dbridement of the area is usually sufficient to anatomy are good, placement of bone-graft material
control the infection. Immediate implant placement is alone is usually sufficient.278
contraindicated in the posterior mandible when insuf- Soft-Tissue Closure and Supportive Therapy.
ficient buccolingual bone exists for initial implant sta- Primary closure is the closure of choice whenever possi-
bility and apical extension of the implant beyond the ble. Care should be taken to maintain and preserve the
floor of the socket will result in damage to the soft tissue during incision and tooth extraction. The soft
mandibular nerve.278 tissue should be repositioned as close as possible to its
Extraction and Curettement Procedure. The original position. When primary closure is not possible,
tooth should be extracted with as little trauma as pos- the site should be covered with a nonresorbable mem-
sible. It is extremely important to retain the cortical brane. Nonresorbable membranes serve as a scaffold for
bone buccal and lingual to the extraction socket. In the soft-tissue growth and migration resulting in closure
case of multirooted teeth, it may be advantageous to over time. An alternative to placement of a nonre-
section the crown and roots so that the roots may be sorbable membrane when primary closure is not possi-
individually extracted. This may save trauma to a thin ble is the use of a connective-tissue graft.278
cortical plate. All soft tissue should be removed from Supportive therapy following immediate implant
the bony crypt with curettes until a solid bone founda- placement should include a bactericidal broad-spec-
tion is achieved. trum antibiotic such as amoxicillin, cephalexin
Implant Placement. After tooth extraction and (Keflex), or clindamycin for a period of 7 to 14 days.
thorough dbridement of the area, the major consider- Nonsteroidal anti-inflammatory drugs have been
ations for implant placement should be the specific shown to be effective in promoting healing following
functional and esthetic needs of the case. The drilling implant placement.278 Chlorhexidine oral rinses
sequence may be altered from that of implant place- should be used routinely following implant-placement
ment in an intact site as tapping and countersinking surgery. When primary closure is not possible and a
may not be necessary. The implant apex should be sta- connective-tissue graft is not done, dbridement of the
bilized in at least 3 to 4 mm of bone and the implant surgical area should be done with a cotton swab soaked
head should be positioned to conform to either the in chlorhexidine. The patient should be instructed to
central fossa, in posterior teeth, or the cingulum, in continue this regimen twice daily until closure has been
achieved. Gelb recommends that the sutures remain in Ruddle,286 Selden,287 Bellizzi and Loushine,288 Reuben
place for 2 weeks and those cases that contain a mem- and Apotheker,289 and others.
brane be monitored every 2 weeks until the membrane Surgical telescopes usually magnify in the range of
is removed.278 2.5 to 6.0, whereas the surgical operating microscope
It is important to emphasize that, although implant has a range of magnification of up to 40. The obvious
surgery is within the scope of endodontics, it is a very question is How much magnification is enough? As
technique-sensitive procedure that requires a relatively the level of magnification increases, the field of vision
long learning curve. It is recommended that the dental and the depth of field (focal depth) decrease, as does
practitioner participate in advanced training programs the aperture of the microscope, therefore limiting the
and gain considerable knowledge and experience in amount of light that reaches the surgeons eyes. This
diagnosis, treatment planning, and placement of makes use of magnification in excess of 30 very
osseointegrated implants before implementing their impractical. The slightest movement of the patient or
use in clinical practice. of the operating microscope will result in the loss of
visual field or focus. This can be very frustrating and
MICROSURGERY result in the time-consuming need to readjust the
For years, many dental practitioners have benefited microscope.
from the use of vision-enhancement devices, such as Magnifications in the range of 2.5 to 8.0 are rec-
loupes, surgical telescopes, and head-mounted surgical ommended for orientation to the surgical field and to
fiber-optic lamps (Figure 12-77). It is generally accepted provide a wide field of view and a good depth of field.
that the better the visual access to the operating field, the Midrange magnifications in the 10 to 16 are best for
higher the quality of treatment that can be accomplished. performing procedures such as root-end resections and
Perhaps one of the most important recent develop- root-end preparations. Higher range magnification in
ments in surgical endodontics has been the introduction the area of 18 to 30 should be reserved for observing
of the surgical operating microscope (Figure 12-78). and evaluating fine detail.
Otologists were the first medical specialists to introduce Rubinstein has identified several advantages of the
the operating microscope in the early 1940s. Slowly, the surgical operating microscope.290 They include
use of the operating microscope was introduced to the
fields of ophthalmology, neurosurgery, urology, and other 1. Visualizing the surgical field.
medical fields. Pioneers in the use of the operating micro- 2. Evaluating the surgical technique.
scope in surgical endodontics have been Buchanan,280 3. Reducing the number of radiographs needed.
Carr,281,282 Rubinstein,283,284 Pecora and Adreana,285 4. Expanding patient education through video use.
A A
B B
Figure 12-80 A, Beveled surface of the root of a maxillary lateral Figure 12-81 A, Finished root-end filling of a maxillary canine
incisor following root-end resection (16 original magnification). after use of a 30 fluted finishing bur (16 original magnification).
B, Root-end preparation following use of ultrasonic tips. Note use B, Mineral trioxide aggregate (MTA) root filling (26 original mag-
of microsurgical mirror (16 original magnification). nification).
A B
Figure 12-82 A, One-half millimeter blunt Blue Micro Tip mounted in a Stropko Irrigator on a triflow syringe. B, Blue Micro Tip drying
the root-end preparation of a maxillary lateral incisor (20 original magnification).
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265. Bender IB, Rossman LE. Intentional replantation of endodon- Implants 1996;11:205.
tically treated teeth. Oral Surg 1993;76:623. 280. Buchanan LS. The art of endodontics: a rationale for treat-
266. Raghoebar GM, Vissink A. Results of intentional replantation ment. DentToday 1993;12:30.
of molars. J Oral Maxillofac Surg 1999;57:240. 281. Carr GB. Advanced techniques and visual enhancement for
267. Kratchman S. Intentional replantation. Dent Clin North Am endodontic surgery. Endod Rep 1992;7:6.
1997;41:603. 282. Carr GB. Microscopes in endodontics. Calif Dent Assoc J
268. Nosonowitz D, Stanley H. Intentional replantation to prevent 1992;20:55.
predictable endodontic failures. Oral Surg 1984;57:423. 283. Rubinstein R. Horizons in endodontic surgery. Part I:
269. Jansen CE. Implant procedures 101. J Calif Dent Assoc The operating microscope. Oak County (MI) Review
2000;28:277. 1991;30:7.
270. Weine FS, Frank AL. Survival of the endodontic endosseous
284. Rubinstein R. Horizons in endodontic surgery. Part II: The
implant. J Endod 1993;19:524.
operating microscope. Oak County (MI) Review 1992;30:9.
271. Orlay JG. Endodontic splinting treatment in periodontal dis-
285. Pecora G, Andreana S. Use of dental operating microscope in
ease. Br Dent J 1960;108:118.
endodontic surgery. Oral Surg 1993;75:751.
272. Frank AL. Improvement in the crown:root ratio by endodon-
tic endosseous implants. J Am Dent Assoc 1967;74:451. 286. Ruddle CJ. Surgical endodontic retreatment. Calif Dent Assoc
273. Frank AL. Endodontic endosseous implants and treatment of J 1991;19:61.
the wide-open apex. Dent Clin North Am 1967;Nov:675. 287. Selden HS. The role of the dental operating microscope in
274. Frank AL, Abrams AM. Histologic evaluation of endodontic endodontics. Pa Dent J 1986;55:36.
implants. J Am Dent Assoc 1969;78:520. 288. Bellizzi R, Loushine R. Adjuncts to posterior endodontic sur-
275. Branemark PI, Zarb GA, Albektsson T. Tissue-integrated pros- gery. J Endod 1990;16:604.
thesis. Chicago: Quintessence Publishing; 1985. p. 11. 289. Reuben HL, Apotheker H. Apical surgery with the dental
276. Brunski JB, Moccaia FF, et al. The influence of functional use microscope. Oral Surg 1984;57:433.
of endosseous dental implants on the tissue-implant inter- 290. Rubinstein R. Endodontic microsurgery and the surgical oper-
face. I. Histological aspects. J Dent Res 1979;58:1953. ating microscope. Compend Contin Educ Dent
277. Mombelli A, Van Ossten MAC, et al. The microbiota associat- 1997;18:659.
ed with successful or failing osseointegrated titanium 291. Rubinstein RA, Kim S. Short-term observation of the results of
implants. Oral Microbiol Immunonol 1987;2:145. endodontic surgery with the use of a surgical operating
278. Gelb DA. Immediate implant surgery: ten-year clinical microscope and Super-EBA as root-end filling material. J
overview. Compend Contin Educ Dent 1999;20:1185. Endod 1999;25:43.
Chapter 13
OUTCOME OF ENDODONTIC
TREATMENT AND RE-TREATMENT
John I. Ingle, James H. Simon, Pierre Machtou, and Patrick Bogaerts
A question that should be asked of any discipline or tech- A group at Temple University, for example, reported
nique in dentistry is, What degree of success should be a 95.2% success rate at the end of 1 year with 458 canals
expected? Success, in turn, should be measured longitu- filled by the gutta-percha-euchapercha method.5 They
dinally in timelong-range success as opposed to found that teeth that started with vital inflamed pulps
short-term success. The beautiful resin restoration turn- had more success (98.2%) than teeth with nonvital
ing an ugly yellow in 1 year is not an unqualified success. pulps (93.1%). Contrary to other reports, however, they
By the same token, the denture worn in the bureau were far less successful with short-filled canals (71.1%)
drawer is far from successful, nor is the well-fitting partial than with flush-filled or overfilled canals (100%).
denture successful if it leads to clasp caries in 6 months. (Reports of 100% success must be questioned.)
Moreover, the endodontically treated tooth with a large South African researchers enjoyed a success rate
periradicular lesion that does not show signs of healing 2 similar to that of the Temple University group: 89%
years after treatment cannot be considered a success. success at the end of 1 year.6 Also, as with the Temple
To answer the question, How successful is group, they were successful 92% of the time in teeth
endodontic therapy? a study was undertaken at the filled to the apex and 91% of the time if the canals were
University of Washington School of Dentistry to evalu- overfilled. Filling short of the apex reduced their suc-
ate endodontically treated teeth to determine their rate cess rate to 82%.6
of success. More important to the study, the rate of fail- The poorest reported rate of success dealt with 845
ure was also established, and the causes of failure were Dutch military servicemen.7 After 17 years, 45% of the
carefully examined. Analysis of the failures led to mod- endodontically treated teeth had failed in nonaviators,
ifications in technique and treatment. Finally, the entire whereas only 7% had failed in aviator patients. There is
discipline of endodontic therapy was re-examined, and a simple explanation for this wide discrepancy in fail-
definitive improvements were made as a result. The ure rate. The aviators were usually treated with
improvements in treatment are reflected in the gutta-percha or silver point fillings, whereas the non-
improvement in success, which increased to 94.45% aviators were more frequently treated by therapy with
from a former success rate of 91.10%, an improvement special chemical compounds. Furthermore, the avia-
of 3.35 percentage points. In other words, nearly 95% tors teeth were more frequently crowned.7
of all endodontically treated teeth were successful. Hession, a highly respected endodontist in Australia,
There was also a hidden agenda to the Washington reported the highest rate of success: 98.7% of 151
studyto prove ourselves to a profession that, at that teeth.8 Nelson reported lower rates in England: 81.9%
time, was skeptical of root canal therapy. In light of of 299 teeth. With re-treatment, however, Nelson sal-
todays knowledge, the project had some design flaws vaged 11 of the treatment failures, raising the success
and misinterpretations and was not that well con- rate to 85.6%.9 Kerekes and Tronstad, using the stan-
trolled, even though each phase was subjected to statis- dardized technique recommended in this text, had a
tical analysis. The null hypothesis was ignored in an success rate similar to the Washington study,10 as did
effort to prove a point: root canal therapy could be Sjgren and his associates from Sweden.11 Their
successful if properly done. On the other hand, the fig- remarkable study of 356 endodontic patients, re-exam-
ures of the Washington study compared favorably with ined 8 to 10 years later, reported a 96% success rate if
other reports of success.113 the teeth had vital pulps prior to treatment. The success
a 91.10% success rate104 failures of 1,067 cases. year recalls, 281 teeth were successfula success rate of
After these improvements were instituted, the success 93.05%; 21 teeth were considered failuresa failure
rate rose to 94.45%9 failures of 162 cases. rate of 6.95%. These figures compare favorably with the
Five-Year Recall Analysis. From the beginning of 2-year recall analysis.
the study, enough 5-year recalls had returned to make a Two-Year Recall Analysis by Age of Patient.
statistically valid analysis of these cases. Of the 302 5- Reference is frequently made to age as a criterion for
A B C
Figure 13-4 A, Before radiograph, with large periradicular lesion. B, Treatment radiograph immediately following periradicular sur-
gery. Also note the fractured root tip of a central incisor (arrow) that tests vital. C, Two-year postoperative radiograph of successfully treat-
ed case. Lack of total periradicular repair (moderate repair) is related to extensive surface of filling material over which cementum cannot
grow. Also note fracture repair (arrow) of vital central incisor.
A B
Figure 13-5 A, Pulpless mandibular lateral incisor with no periradicular lesion. B, Constant periradicular health is revealed in a 2-year post-
operative radiograph, a successful case.
Figure 13-8 Large periradicular lesion (left) has healed completely (right) within 6 months in a patient 20 years of age.
Table 13-1 Distribution of Failures of Treated accounts for 9.61% of the failures. Thus, the two great-
Endodontic Cases: Two-Year Recall by Frequency of est causes of failure stand revealed: inadequate clean-
Occurrence ing and shaping and incomplete obturation. In other
words, over two-thirds of all of the endodontic failures
Causes of Failure Number of Failures % Failures
in the study were related to inadequate performance of
Incomplete obturation 61 58.66 two points of the endodontic triad, canal instrumen-
Root perforation 10 9.61 tation and canal obturation. This alone would call for
improved technique and attention to detail.
External root resorption 8 7.70
Categorical Arrangement of Causes of Failure.
Coexistent periodontal- 6 5.78 The 13 causes of endodontic failure may be arranged in
periradicular lesion three general categories of causes leading to failure: (1)
Canal grossly overfilled 4 3.85 apical percolation, (2) operative errors, and (3) errors
or overextended in case selection (Table 13-2). Actually, a clear-cut
Canal left unfilled 3 2.88 delineation of the agents of failure is difficult; apical
percolation into the canal accounts for almost all of
Developing apical cyst 3 2.88
these failures, as Table 13-2 shows.
Adjacent pulpless tooth 3 2.88 Apical Percolation. Three of the causes of failure
Silver point 2 1.92 shown in Table 13-2 lead to apical percolation and sub-
inadvertently removed sequent diffusion stasis into the canal (Figures 13-10
Broken instrument 1 0.96 and 13-11). Factor in the bacteria lurking in the region
Accessory canal unfilled 1 0.96 and these three causes together account for 63.47% of
all of the endodontic failures in the study and demon-
Constant trauma 1 0.96
strate how vital careful therapy is to success. One must
Perforation, nasal floor 1 0.96 also consider the potential of microleakage under and
Total failures 104 100.00 around coronal restorations: bacteria penetrating from
the crown to the periapex alongside poorly obturated
Distribution of 104 endodontic failures 2 years following therapy. canals.
When arranged by frequency of occurrence, note that incomplete Operative Errors. A category made up of errors in
obturation accounts for almost 60% of all failures, followed by root
perforation, which accounts for nearly 10% of 104 failures. Cause
coronal cavity preparation and canal preparation
of failure includes infrequently encountered conditions that occur accounts for almost 15% of the failures (root perfora-
less than 1% of the time. tion, 9.61%; broken instrument, 0.96%; and canal gross-
ly overfilled, 3.85%; total, 14.42% of all of the failures).
Table 13-2 Distribution of Failures of Treated These operative errors are all related to inadequate coro-
Endodontic Cases: Two-Year Recall by Category of nal cavity preparation, improper use of endodontic
Cause of Failure instruments and filling materials, and lack of standardi-
zation of endodontic equipment and material as it
Causes of Failure Number of Failures % Failures
arrives from the manufacturer. The latter problem has
Apical percolationtotal 66 63.46 now been reduced through instrument standardization.
Incomplete obturation 61 58.66 On the other hand, delicate root canal instruments
must not be mistreated by the inexperienced, and one
Unfilled canal 3 2.88
of the common complaints of the neophyte is instru-
Ag point inadvertently 2 1.92 ment breakage. Also, improper use of the instruments
removed causing root perforation and apex perforation
Operative errortotal 15 14.42 accounted for 14 of the 104 failures in the study.
Root perforation 10 9.61 Penetrating through the side of a curved root ultimate-
ly leads to incomplete instrumentation and incomplete
Canal grossly overfilled 4 3.85
obturation (Figure 13-12).
or overextended
Opening wide the apical foramen during instru-
Broken instrument 1 0.96 mentation illustrates that this is also a form of perfora-
Errors in case selectiontotal 23 22.12 tion and leads to gross overfilling or overextension.
Healing is delayed and often incomplete around the
External root resorption 8 7.70
grossly overfilled areas that may be caused by foreign-
Coexistent periodontal- 6 5.78 body reaction. Moreover, the perforated apical foramen
periradicular lesion has destroyed the apical stop and does not allow com-
Developing apical cyst 3 2.88 paction during canal filling. Although the canal may
Adjacent pulpless tooth 3 2.88 appear overfilled, it is actually incompletely obturated,
with resulting percolation and failure (Figure 13-13).
Accessory canal unfilled 1 0.96
The paucity of failures in this study owing to broken
Constant trauma 1 0.96 instruments illustrates that this is not as desperate a sit-
Perforation, nasal floor 1 0.96 uation as it is often considered to be. In analyzing the
Total failures 104 100.00 University of Washington caseload, Crump and Natkin
found that failure following instrument fragmentation
Distribution of 104 endodontic failures 2 years following therapy. was the same as in other endodontic cases.20
Causes of failure may be categorized into three general groupings: Broken instruments, however, are not favored any
apical percolation, which accounts for 63.46% of failures; operative
more than overfilling and underfilling are favored, but,
errors, which account for 14.42% of failures; and errors in case
selection, which account for 22.12% of the 104 failures. occasionally, both accidents may occur. Surgical treat-
ment is recommended in operable teeth if the instru-
ment is broken off in the apical one-third of the canal
A B
Figure 13-10 A, Although the root canal filling appears to be overextended, the fuzzy appearance indicates a lack of density necessary for
total obturation. Apical perforation destroyed the apical constriction necessary for compaction of the root canal filling. B, Root end biopsy
of this failure case shows root canal cement and cellular debris rather than well-condensed gutta-percha filling. Constant percolation into the
root canal space provides media for bacterial growth.
A B
Figure 13-11 A, Constantly draining sinus tract opposite the mesiobuccal root of a maxillary first molar (arrow) was thought to be relat-
ed to an advanced periodontal lesion. Total amputation of the mesiobuccal root is indicated. B, Amputated root reveals an error in diagno-
sis. The reamer is in an undetected second canal, whereas the arrow points to an obturated primary canal. Secondary canals in mesiobuccal
roots of first permanent molars occur about 60% of the time.
A B
Figure 13-13 A, Although this incisor appears to be grossly overfilled, careful examination (arrow) reveals failure to totally obturate the
canal. B, Tissue reaction to overfilling and underfilling in a single biopsy specimen from this failure case. Curved arrows direct attention to
a mass of cement forced into periradicular tissue. Heavy black arrow (right) indicates noninflammatory tissue capsule that has developed as
foreign-body reaction. Open arrow (bottom) points to a violent inflammatory reaction and an abscess related to bacterial products perco-
lating from the unfilled canal.
lesion would lead to failure?21 These are all factors that lar lingual grooves extending to the apex24 (Figure 13-
led to some of the failures in the Washington study, fac- 14) or the resorptive invasion from one endodontic
tors that constitute 22.12% of the total failures. Some lesion causing the necrosis of an adjoining tooth25
could well have been predicted at the time of therapy, (Figure 13-15).
but others were entirely unpredictable. There are, of course, multiple causes of failure not
As Table 13-2 shows, there were also minor causes revealed in the Washington study: retrofilling failures,
of failure: constant occlusal trauma from bruxism,22 root tip and foreign bodies left in surgical sites, root
perforation of the nasal floor, and unfilled accessory fenestration following surgery (Figure 13-16), cracked
or lateral canals. The low incidence of failure associat- or split roots, or carious destruction unrelated to the
ed with unfilled accessory canals came as a surprise root canal treatment (Figure 13-17). Ultimately, in all
considering the degree of emphasis placed by some on of these situations, bacteria are the final cause of fail-
the absolute necessity of totally obliterating these lat- ure. One must also recognize that one of the most fre-
eral canals. quent causes of failure of the treated pulpless tooth is
Returning to some of the greater causes of failure, fracture of the crown. The tooth must be carefully pro-
one should note that all eight cases of continuing root tected by an adequate restoration.
resorption were in maxillary lateral incisors. So one The Washington study has been faulted by some for
should be wary in evaluating the future of these teeth if being only a radiographic study. As Brynolf pointed
they exhibit extensive apical resorption prior to treat- out in her classic punch biopsy study of root-filled
ment. Most external apical root resorption stops in teeth in cadavers, histologic evaluation is a much more
response to successful root canal treatment! accurate method of determining if inflammation
Endodontic failure associated with periodontal remains at the apex than is radiologic evidence.26 But
pockets is usually the fault of the dentist for not recog- her research was done on cadavers, proving the imprac-
nizing the pockets existence. One stumbles ahead with ticality of punch biopsy on live patients. Green and
the endodontics before careful probing reveals the Walton followed up on Brynolf s approach, comparing
presence of an associated pocket and that concurrent histologic and radiographic findings on cadavers, and
periodontal/endodontal therapy will be necessary.23 also found that 26% of the teeth with no radiolucen-
In some cases, concurrent treatment may not solve cies showed chronic inflammation histologically.27 But
an unsolvable problem. Witness the destructive and that is not to say that these teeth were uncomfortable or
irreparable nature of some dens invaginatus or radicu- contributing to the patients poor health. How success-
A B
Figure 13-15 A, No radiolucency is apparent on a 4-year recall radiograph following root canal filling of a first premolar. Note the anatomic defect
on the canine (arrow). B, Radiograph taken 6 years after the lesion was first noticed. Failed root canal filling in the premolar led to periradicular
lesions, inflammatory external resorption of canine, and ultimately necrosis of the canine pulp. Reproduced with permission from Frank AL.25
ful is success? Better yet, what are the criteria of suc- the highest percentage of success is with teeth with
cess? Comfort and function? Radiographic? Histologic? vital pulps and the worst prognosis is for those with
Since histologic evaluation is impractical, if not illegal, large, long-standing periradicular lesions.
one would have to go with comfort and function and 2. The more dental treatment that is done, the poorer
the radiographic findings. the prognosis. In other words, good nonsurgical
There are well over 50 studies attempting to delin- endodontic treatment has the best prognosis. The
eate how successful our treatment procedures are and worst prognosis lies with teeth that have been re-
what the prognosis is for a particular form of treat- treated nonsurgically and then re-treated surgically
ment.28 All in all, the studies that have been done sug- once or twice more.
gest the following generalizations:
MICROBES
1. The more extensive and severe the endodontic To further elaborate on the role bacteria play in pulpal
pathosis, the poorer the prognosis. In other words, and periradicular disease, one must turn to the classic
research by Kakehashi and his associates at the National
Institute of Dental Research.29 They were able to show,
in a gnotobiotic study, that microorganisms alone
cause pulpal inflammation and necrosis as well as peri-
radicular infection.29 It follows that inadequate
removal of microbes (ie, bacteria, fungi, and viruses)
from the canal leads to continued infection and inflam-
mation30 and that all of the defects listed in the
Washington study are ultimately reduced to bacterial
invasion and/or colonization.
But what happens when everything is done right (ie,
cleaning, shaping, and obturation), yet failure still
occurs?3134 Can bacteria still be present after adequate
endodontic treatment?
There is strong evidence that bacteria may not be
Figure 13-16 Severe bony and soft tissue dehiscence extending to
completely eliminated after thorough cleaning, shap-
the periapex of a traumatized incisor. Postoperative defects of this
type may develop following surgery in an area of osseous fenestra- ing, and disinfection.3537 Moreover, when obturation
tion. Reproduced with permission from Luebke RG, Glick DH, is postponed, bacteria may be able to recolonize in the
Ingle JI. Oral Surg 1964;18:97. canal.38 Furthermore, try as one might, no preparation
technique can totally eliminate the intracanal irritants, age.41 Indeed, gutta-percha root canal fillings do not
and a critical amount can sustain periradicular resist salivary contamination.42,43 As Ray and Trope
inflammation (Figure 13-18).39,40 have been able to show, long term prognosis of
In addition, as stated previously, the obturated treatment seems to correlate directly with the quali-
canal may be recontaminated from coronal leak- ty of the coronal seal.44
A B
C D
Figure 13-18 A, The radiograph shows a mandibular cuspid that appears well obturated with a well-fitting coronal restoration. B, A sinus
tract is traced with a gutta-percha point to the apical lesion that has not responded to treatment. C, Surgical resection of the root end. D,
High-power photomicrographs show bacteria containing plaque on the external root surface.
There are also times when an irritant, such as infected respond to the irritants and inflammation and prolifer-
dentin chips, is packed at the apex or pushed through the ate into a cyst-like attempt to wall off the irritants.78
apex, there to serve as a continuing irritant45,46 that over- It has been suggested that these latent epithelial cell
whelms the bodys defense system. As stated before, the rests could be activated by the epidermal growth factor
periapical tissue could become colonized by periodontal present in saliva that contaminates canals left open for
contamination,47 the virulence of the bacteria, or extru- drainage.79,80 In the absence of treatment, or in the pres-
sion by overaggressive instrument action.4850 ence of persistent bacteria, epithelium continues to pro-
In most cases, the hosts immune system can overcome liferate to become a bay (pocket) cyst and eventually a
these antigens.51 On the other hand, some bacteria pos- true cyst.81,82 The distinction between a bay (pocket)
sess mechanisms to resist phagocytosis such as encapsu- cyst (Figure 13-20) and a true cyst is important from a
lation or the production of proteases aimed against the clinical standpoint. Since root canal therapy can directly
immune system.52,53 Bacteria may also bury themselves affect the lumen of the bay (pocket) cyst, the environ-
in a thick matrix that acts as a sort of apical plaque (see mental change may bring resolution of the lesion.
Figure 13-18, D).5456 There is a controversy over whether cysts heal after
Many organisms can survive in periradicular lesions: nonsurgical endodontic treatment. The true cyst is
Actinomyces, Peptostreptococcus,5760 Propionibac- independent of the root canal system, so conventional
terium,61,62 Prevotella and Porphyromonas, 6365 therapy may have no effect on it. The prevalence of true
Staphylococcus,66,67 and Pseudomonas aeruginosa.35 cysts is less than 10%. 65,66 Most practitioners now real-
Barnett, in fact, has stated that Pseudomonas refractory ize that true cysts, as well as some bay (pocket) cysts,
periradicular infection could be cured only by heavy probably do not heal with nonsurgical therapy. In spite
doses of metronidazole (Flagyl) following the failure of of good cleaning, shaping, and filling, these lesions
re-treatment and apicoectomy.68 have to be surgically removed to effect healing.
The dangers delineated above emphasize the point
FOREIGN BODIES initially stressed: if the case is carefully selected before
In spite of what has been stated above, foreign-body treatment, if the canal is correctly instrumented and
giant cell reaction can occur without the presence of obturated, and if the crown is properly restored, the
bacteria, but no fulminating infection will develop ultimate outcome should be successful.
without the bacteria.
A number of foreign bodies have been reported:
lentil beans,69 other vegetables,70 popcorn kernels71
(Figure 13-19), paper points, cellulose, and a variety of
unidentified materials.72 Human body defense cells are
unable to digest cellulose or cotton pellets.72,73
In addition, various lipids, cholesterols, and crystals
have also been implicated as periradicular irritants. By
their very presence, these intrinsic factors are capable of
sustaining an apical lesion despite correct endodontic
treatment.74
Root canal sealers can also act as a foreign body and
thus sustain a lesion, although, over time, extruded
sealers (and gutta-percha) may be phagocytized by
macrophages.75
The cytotoxicity of freshly mixed and unset sealers is
well documented.76 In the long term, however, obtura-
tion materials are far less irritating than microbes.75 It
can be concluded that an overfill may cause a delay in
healing but will not prevent it.77
EPITHELIUM
The role of epithelium must also be taken into account Figure 13-19 Biopsy of what was thought to be a root tip reveals
when reviewing failure to heal periapically. If the rest- columnar-like cells (arrow) of the outer husk of a popcorn kernel that
ing cells of Malassez remain in the region, they may was trapped in a fresh surgical area and served as a severe irritant.
A B
Figure 13-20 A, Periradicular lesion persisting 2 years following endodontic therapy appears to be either an apical cyst or chronic apical
periodontitis. B, Biopsy of the periapex demonstrated the epithelial lining of an apical cyst (arrow). Persistence of development of apical cysts
led to failure in three cases in study.
Measures to be Employed to Improve Success. 6. Use great care in fitting the primary filling point.
One may draw certain conclusions from this study and One must be certain to obliterate the apical portion
finally list a number of procedures to improve the rate of the canal. Be more exacting in the total obtura-
of success of treated endodontic cases. These are the tion of the entire root canal. Always use a root canal
Ten Commandments of Endodontics: sealer cement.
7. Use periradicular surgery only in those cases for
1. Use great care in case selection. Be wary of the case which surgery is definitely indicated.
that will be an obvious failure, but, at the same time, 8. Always check the apical density of the completed
be daring within the limits of capability. root canal filling of the patient undergoing peri-
2. Use greater care in treatment. Do not hurry; main- radicular surgical treatment, and this should be
tain an organized approach. Be certain of instru- done by using a sharp right-angled explorer. If
ment position and procedure before progressing. found wanting, the apical foramen is prepared and
3. Establish adequate cavity preparation of both the retrofilled.
access cavity, which can be improved by modifica- 9. Properly restore each treated pulpless tooth to pre-
tions of the coronal preparation, and the radicular vent coronal fracture and microleakage.
preparation, which can be improved by more thor- 10. Practice endodontic techniques until the proce-
ough canal dbridementcleaning and shaping. dures are as routine as the placement of an amal-
4. Determine the exact length of tooth to the foramen gam restoration or the extraction of a central inci-
and be certain to operate only to the apical stop, sor. Practice on extracted teeth mounted in acrylic
about 0.5 to 1.0 mm from the external orifice of the blocks is especially recommended.
foramen.
5. Always use curved, sharp instruments in curved Careful attention to details in following the Ten
canals, and especially remember to clean and Commandments of Endodontics will ensure a degree
reshape the curved instrument each time it is used. of success approaching 100%.
This applies to stainless steel instruments.
A B C
Figure 13-22 A, Failure case with apical and lateral periradicular lesions. B, Re-treatment eliminates bacterial infection through extensive
recleaning, reshaping, and canal medication. Obturation by vertical compaction fills the lateral canal as well. C, Complete healing 1 year later.
(Courtesy of Dr. Pierre Mactou.)
state of the tooth (as above) obviously being a key fac- acute symptomatic teeth.110 At the same time, others
tor in outcome.106 Stabholz et al.107 and Friedman108 have noted that these bacteria may have been planted
have noted that causes of endodontic failure fall into there as contaminants during previous endodontic
three categories: preoperative, intraoperative, and post- treatment.110116 As previously stated, infected dentin
operative causes. Of these three, intraoperative, that is, chips, extruded from overinstrumentation, may also be
iatrogenic, causes are the most prevalent but the most the root cause of refractory infections.103 Bergenholtz
easily controlled.109 For example, Nair has pointed out has stated thatroot filling material [per se] was not
that refractory periradicular infections are found in the immediate cause of the unsuccessful cases, but that
Table 13-3 Cross-sectional Studies on the Presence of Periapical Periodontitis (PAP) in Nontreated and
Endodontically Treated Teeth and Quality of Treatment
Endodontically Endodontically Treated Technically Inadequate
Lead Author Country Teeth with PAP (%) Treated Teeth (%) Teeth with PAP (%) Treatment (%)
Table 13-4 Nonsurgical Endodontic Re-treatment Table 13-5 Nonsurgical Endodontic Re-treatment
Outcome in Pulpless Teeth without Periapical Outcome in Teeth with Periapical Periodontitis
Periodontitis
Success Failure
Authors Cases Success (%) Authors Cases (%) Uncertain (%)
A B C
Figure 13-23 A, Failed endodontic treatment caused by overinstrumentation and failure to totally obturate the canal. Note the gross overex-
tension of sealer and that the final 6 mm of the canal are sealer only. B, Re-treatment by complete recleaning, reshaping, and canal medica-
tion before final obturation. C, Twelve-year recall shows total healing. Note recurrent decay at the distal margin of the crown (arrow) that
can lead to microleakage and potential failure. (Courtesy of Dr. Pierre Mactou.)
The canal should be cleaned segment by segment in the first place. One is warned that these cases are
through a coronal reservoir of 2.5% of sodium challenging, and this is probably not the occasion for
hypochlorite. Working length at the radiographic ter- one-appointment therapy. Continuing failure is
minus is established late in treatment, when the undoubtedly owing to remaining bacteria, and their
remainder of the canal has already been cleaned and elimination calls for extra effort. New data regarding
shaped. Maintenance of apical potency and constant failed root canals indicate that these microflora120122
recapitulation with fine files avoids canal blockage with differ from those of untreated necrotic teeth.
dentin debris. It also allows the sodium hypochlorite to Enterococci, for example, are quite prevalent in previ-
reach this area. Great care must be exercised when ously root-filled teeth and are quite difficult to elimi-
removing the previous filling material, particularly nate. Enterococcus faecalis is the most frequent strain and,
when solvents such as chloroform are used. as a monoinfection, is found in 33% of the cases.123
It is very difficult to remove all of the sealer and Entercocci are quite resistant to calcium hydroxide, so
gutta-percha from the canal walls. Wilcox et al. con- Safaui et al. have recommended the addition of iodine
tended that the last remnants of sealer can be removed potassium iodide in these cases.124 Heling and Chandler
only by vigorous reinstrumentation and reshaping of have recommended a mixture of 3% hydrogen peroxide
the canal117,118 but cautioned that overenlargement and 1.8% chlorhexidine as an alternative against E. fae-
may result.119 It would appear that sealer removal is calis.125 Staphylococcus aureus and Pseudomonos are also
most important since bacteria can easily hide under notorious refractory contaminants and may require a
previous sealer. prescription of metronidazole and amoxicillin to rid the
periapex of these bacteria.126128
CANAL MEDICATION
Re-treatment cases are notorious for continued failure! OBTURATION AND RESTORATION
In all probability this is caused by the failure to remove It goes without saying that total obturation is the sine
or kill the refractory bacteria responsible for the lesions qua non of successful re-treatment.
A B
Figure 13-24 A, Pretreatment radiograph reveals failed endodon-
tic treatment and a periradicular lesion. B, Re-treament by total
recleaning, reshaping, and canal medication. Final obturation by
vertical compaction fills the lateral canal as well. C, Six-year follow-
up. (Courtesy of Dr. Pierre Mactou.)
B C
For this, the reader is referred to chapter 11. 5. Morse DR, et al. A radiographic evaluation of the periradicu-
Furthermore, since many failures are believed to be lar status of teeth treated by the gutta-percha-eucapercha
related to microleakage from around coronal restora- endodontic method: a one year follow-up study of 458 root
canals, Part III. Oral Surg 1983;56:190.
tions, it is imperative that the re-treated tooth be prop- 6. Barbakow FH, et al. Endodontic treatment of teeth with peri-
erly restored, at once, not weeks later (Figure 13-24). radicular radiolucent areas in a general dental practice.
Molven and Halse have said it best: Success depends Oral Surg 1981;51:552.
on the elimination of root canal infection present when 7. Meeuwissen R, Eschen S. Twenty years of endodontic treat-
treatment starts, and the prevention of both contami- ment. JOE 1983;9:390.
nation during treatment and re-infection later. So suc- 8. Hession RW. Long-term evaluation of endodontic treatment:
anatomy, instrumentation, obturationthe endodontic
cess rates reflect the standard of the cleaning, shaping practice triad. Int Endodont J 1981;14:179.
and filling of root canals129 (Figure 13-25). 9. Nelson IA. Endodontics in general practicea retrospective
survey. Int Endodont J 1982;15:168.
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(February). endodontic treatment of teeth with apical periodontitis.
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Chapter 14
ENDODONTIC MISHAPS:
THEIR DETECTION, CORRECTION,
AND PREVENTION
Robert J. Frank
Endodontics is currently in the midst of its own procedural accident. Unfortunately, in some instances,
Industrial Revolution. The technological advances the mishap causes such extensive damage to the tooth
made routinely since the early part of this decade have that it may have to be extracted.
far exceeded the progress made since the discipline was Re-evaluation of the prognosis of a tooth involved
first recognized as a specialty. The advent of nickel- in an endodontic mishap is necessary and important.
titanium files, rotary instrumentation, endosonics, The re-evaluation may affect the entire treatment plan
radiovisiography, the endoscope, and the clinical micro- and may involve dentolegal consequences. Dental stan-
scope are but a few innovations that have changed the dard of care requires that patients be informed about
way in which endodontics is practiced. This progress any procedural accident.
has increased both productivity and quality of care. The How can mishaps be prevented? The literature pro-
publics awareness and interest in preserving their teeth vides much information that can help prevent acci-
are increasing, and cases that heretofore were not
attempted are now being successfully managed.
Improved instruments and equipment have contributed Table 14-1 Endodontic Mishaps
to the quality of care. On the other hand, the complexi- Access related
ty of the cases being treated by both general dentists and Treating the wrong tooth
endodontists is increasing, with the result that new Missed canals
problems are being created.Re-treatodontics and dis- Damage to existing restoration
assembly are new terms that have arisen as the profes- Access cavity perforations
sion attempts to correct these new problems, or proce- Crown fractures
dural mishaps as they are called. The purpose of this
Instrumentation related
chapter is to present common mishaps and the treat-
Ledge formation
ment approaches for managing them.
Cervical canal perforations
Endodontic mishaps or procedural accidents are
Midroot perforations
those unfortunate occurrences that happen during
Apical perforations
treatment, some owing to inattention to detail, others
Separated instruments and foreign objects
totally unpredictable. The mishaps listed in Table 14-1
Canal blockage
will be described in detail, including how to recognize
them, how to correct them, how they affect prognosis, Obturation related
and how to prevent them. Over- or underextended root canal fillings
Recognition of a mishap is the first step in its man- Nerve paresthesia
agement; it may be by radiographic or clinical observa- Vertical root fractures
tion or as a result of a patient complaint; for example,
Miscellaneous
during treatment, the patient tastes sodium hypochlo-
Post space perforation
rite owing to a perforation of the tooth crown allowing
Irrigant related
the solution to leak into the mouth.
Tissue emphysema
Correction of a mishap may be accomplished in one
Instrument aspiration and ingestion
of several ways depending on the type and extent of
dents. It is also true that experience can teach many probably a misdiagnosis; in the second instance, a
valuable lessons if one pays attention. Put another way, tooth adjacent to the one scheduled for treatment was
we learn from our own and others mistakes, and that inadvertently opened.
can be true of endodontic mishaps as well. So when a Correction includes appropriate treatment of both
file separates in a canal, the floor of the chamber is per- teeth: the one incorrectly opened and the one with the
forated while searching for canal orifices, or any of sev- original pulpal problem. It is not prudent to hide such
eral other unfortunate procedural accidents occur, an error from the patient. Mistakes happen in all
immediately inform the patient, correct the mishap, aspects of dental care. When a mistake does happen,
and re-evaluate the prognosis. Examine the various the safest approach, even if embarrassing, is to explain
steps that led to the mishap and determine how it could to the patient what happened and how the problem
have been avoided. Treatment evaluation can help pre- may be corrected.
vent future occurrences. Prevention. Mistakes in diagnosis can be reduced by
Endodontic mishaps sometimes have dentolegal attention to detail and obtaining as much information
consequences. These can be minimized or avoided by as possible before making the diagnosis. In terms of
providing patients with adequate information prior to arriving at a correct diagnosis, the baseball rule of
the endodontic procedure. The following suggestions three strikes and yer out can be applied to endodon-
can help in establishing good patient communication: tics: before making a definitive diagnosis, obtain at least
three good pieces of evidence supporting the diagnosis.
1. Inform the patient before treatment about the pos- For example, a radiograph showing a tooth with an
sible risks involved. If the patient has been told that apical lesion may suggest pulp necrosis. But to be cer-
a porcelain crown may chip during treatment, when tain of that diagnosis, it is necessary to have additional
this occurs it will not be unexpected. information such as a lack of response to electric pulp
2. When a procedural accident occurs, explain to the testing. A draining sinus tract leading to the tooth apex
patient the nature of the mishap, what can be done to should be proved radiographically with a gutta-percha
correct it, and what effect the mishap may have on the point inserted in the tract and radiographed. Three
tooths prognosis and on the entire treatment plan. such pieces of information make a diagnosis of pulp
3. If a procedural accident leads to a situation that is necrosis reasonable and a treatment plan that includes
beyond the treating dentists training and ability to root canal therapy logical.
handle, he or she should recognize the need to refer If less than three pieces of information are available,
the patient to a specialist. It is important to note here a definitive diagnosis may not be possible. The patient,
that the standard of care in endodontics has only however, may request that something be done because
one level; both general dentists and specialists are the symptoms are too unpleasant to endure. In such a
held to the same standard. case, it may be necessary to extirpate the pulp as a diag-
nostic procedure to obtain more information for a
For a more extensive discussion of endodontics and definitive diagnosis. If the patient agrees and under-
the law and informed consent, see chapter 1. stands that such a diagnostic procedure also requires
ACCESS-RELATED MISHAPS completion of the root canal therapy even if it turns
out that the problem is with another tooth, then it is
Treating the Wrong Tooth not unreasonable to proceed. It is, however, usually
If there is no question about diagnosis, treating the best, if the diagnosis is tentative, to apply the remedy of
wrong tooth falls within the category of inattention tincture of time to allow signs and symptoms to
on the part of the dentist. Obviously, misdiagnosis become more specific. This may prevent unnecessary
may happen and should not be automatically consid- procedures or an incorrect diagnosis.
ered an endodontic mishap. But if tooth #23 has been Once a correct diagnosis has been made, the embar-
diagnosed with a necrotic pulp and the rubber dam is rassing situation of opening the wrong tooth can be
placed on tooth #24 and that tooth opened, that is a prevented by marking the tooth to be treated with a pen
mishap. before isolating it with a rubber dam (Figure 14-1).
Recognition that the wrong tooth has been treated is
sometimes a result of re-evaluation of a patient who Missed Canals
continues to have symptoms after treatment. Other Some root canals are not easily accessible or readily
times, the error may be detected after the rubber dam apparent from the chamber; additional canals in the
has been removed. In the first instance, the error was mesial roots of maxillary molars and distal roots of
A B
Figure 14-5 Supracrestal perforation repair. A, Note the perforation (arrow) made in the mesial wall during access preparation. B, Repair
was done with amalgam; a matrix band was placed to confine the alloy, following which the filling was carved smooth.
(Figure 14-5). Cavit (Premier Dental Products, King of A material recently approved by the US Food and
Prussia, Pa.) will usually serve to seal these types of per- Drug Administration, mineral trioxide aggregate
forations during endodontic treatment. (MTA) (Pro-Root, Dentsply/Tulsa Dental, Tulsa,
Perforations into the periodontal ligament, whether Okla.), has shown convincing results (Figure 14-6),12
laterally or into the furcation, should be done as soon and several new studies have supported its use for per-
as possible to minimize the injury to the tooths sup- foration repairs.1217
porting tissues. It is also important that the material Hartwell and England reported less than promising
used for the repair provides a good seal and does not results using Teflon and/or decalcified freeze-dried
cause further tissue damage. bone to repair furcal perforations in monkeys.18 No
Several materials have been recommended for per- reparative bone formation developed, and epithelial
foration repair: Cavit,2 amalgam,3 calcium hydroxide downgrowth from the sulcus separated the connective
paste,4 Super EBA,5 glass ionomer cement,6 gutta-per- tissue and bone from cementum. It is apparent that a
cha,7 tricalcium phosphate,8 or hemostatic agents such furcal perforation that is not successfully repaired will
as Gelfoam.9 An in vitro dye penetration study creating soon communicate with the sulcus, resulting in a more
an artificial floor using either calcium sulfate or serious problem.
hydroxyapatite and then repairing the perforation with Prior to repair of a perforation, it is important to
Vitrebond (3M, St. Paul, Minn.) was reported by control bleeding, both to evaluate the size and locations
Alhadainy and Abdalla.10 The results indicated that cal- of the perforation and to allow placement of the repair
cium sulfate and hydroxyapatite, used as barriers, sig- material. Calcium hydroxide placed in the area of per-
nificantly improved the sealing ability of Vitrebond and foration and left for at least a few days will leave the
provided successful barriers against its overextension. area dry and allow inspection of perforation. Mineral
Mittal and coworkers reported their in vitro repair of trioxide aggregate, in contrast to all other repair mate-
furcation perforations using plaster of Paris with various rials, may be placed in the presence of blood since it
other materials.11 Evaluation using dye leakage showed requires moisture to cure. It is nevertheless preferable
amalgam to have the highest amount of leakage, fol- to control bleeding prior to repair so that the location
lowed in decreasing order by glass ionomer, composite, can be more accurately determined.
IRM, and AH26. An in vivo application of this technique Prognosis for a perforated tooth must generally be
is necessary, however, to evaluate periradicular respons- downgraded. How much it is downgraded is a clinical
es to these materials and long-term success. decision based on the circumstances such as the perfo-
The concept of using an artificial barrier against ration size and the existing periodontal condition. Sinai
which to condense and help confine the repair materi- proposed that the prognosis for a tooth with a perfora-
al has led to the use of absorbable, hemostatic collagen tion depends on the location of the perforation, the
products, such as Collastat OBP (Vitaphore Corp.) and length of time the perforation is open to contamina-
CollaCote (Colla-Tec, Inc, Plainsboro, N.J.). tion, the ability to seal the perforation, and accessibili-
B C
ty to the main canal.19 The overall success rate for per- and correct location, both permitting direct access to
foration repairs based on 55 cases was reported by the root canals. A thorough knowledge of tooth anato-
Kvinnsland et al. as 92%.20 Generally, it can be said that my, specifically pulpal anatomy, is essential for anyone
the sooner repair is undertaken, the better the chance performing root canal therapy.
of success. Surgical corrections may be necessary in
refractory cases. Crown Fractures
Prevention. Thorough examination of diagnostic Crown fractures of teeth undergoing root canal therapy
preoperative radiographs is the paramount step to are a complication that can be avoided in many instances.
avoid this mishap. Checking the long axis of the tooth The tooth may have a preexistent infraction that becomes
and aligning the long axis of the access bur with the a true fracture when the patient chews on the tooth weak-
long axis of the tooth can prevent unfortunate perfora- ened additionally by an access preparation.
tions of a tipped tooth. The presence, location, and Recognition of such fractures is usually by direct
degree of calcification of the pulp chamber noted on observation. It should be noted that infractions are often
the preoperative radiograph are also important infor- recognized first after removal of existing restoration in
mation to use in planning the access preparation. preparation of the access. When infractions become true
Perforations can also often be associated with an inad- fractures, parts of the crown may be mobile.
equate access preparation. Prevention of procedural Treatment. Crown fractures usually have to be
mishaps is best accomplished by close attention to the treated by extraction unless the fracture is of a chisel
principles of access cavity preparation: adequate size type in which only the cusp or part of the crown is
A B
C D
Figure 14-7 Tooth loss resulting from failure to reduce occlusion at onset of endodontic therapy. A, Preoperative radiograph. B, Occlusal
view as the patient presented on the second visit. C, Occlusal view of extracted tooth with arrows pointing to the mesiodistal fracture line.
D, Arrow indicating that the fracture had extended to the root surface.
A B
Figure 14-8 Vertical root fracture associated with overzealous canal preparation. A, Postoperative radiograph shows distal canals prepared
and filled leaving a thin-walled root (arrow). B, Twelve months later, the patient reported with a vertical root fracture. It should also be noted
that the pin placed before root canal therapy may also have contributed to a weakened root.
8). Also related to overinstrumentation are canal ledg- ing on itselfa subtle and easily missed radiographic
ings and apical transportations and perforations. characteristic.
Gutmann and Dumsha proposed a range of sizes to be Recognition. Ledge formation should be suspect-
used as a guideline for the apical termination of the ed when the root canal instrument can no longer be
canal preparation.22 For a detailed description of prop- inserted into the canal to full working length. There
er instrumentation techniques, refer to chapter 10. may be a loss of normal tactile sensation of the tip of
the instrument binding in the lumen. This feeling is
Ledge Formation supplanted by that of the instrument point hitting
Ledges in canals can result from a failure to make against a solid wall: a loose feeling with no tactile sen-
access cavities that allow direct access to the apical part sation of tensional binding (see Figure 14-9, A).
of the canals or from using straight or too-large When ledge formation is suspected, a radiograph of
instruments in curved canals (Figure 14-9). The newer the tooth with the instrument in place will provide
instruments with noncutting tips have reduced this additional information. The central x-ray beam should
problem by allowing the instruments to track the be directed through the involved area. If the radiograph
lumen of the canal, as have nickel-titanium files. shows that the instrument point appears to be directed
Occasionally, even skilled and careful clinicians devel- away from the lumen of the canal, completion of the
op canal ledges when treating teeth with unsuspected canal preparation must include an effort to bypass the
aberrations in canal anatomy. ledge formation.
One of the anatomic complexities in root canal Correction. The use of a small file, No. 10 or 15,
therapy is the curved root, which is generally evident with a distinct curve at the tip (see Figure 1049, B),
on radiographs. However, roots that curve toward or can be used to explore the canal to the apex. The curved
away from the central x-ray beam, that is, toward the tip should be pointed toward the wall opposite the
buccal or lingual, are much more difficult to discover. ledge. This is a situation in which the tear-shaped sil-
The frequent finding (55%) of a buccal curvature of icone instrument stops are valuable. The tear is
the palatal root of the maxillary first molar and the pointed in the same direction as the curve of the
labial or lingual curvature of the maxillary central instrument. The vaivn or watch-winding motion
incisor and canine are examples of anatomic varia- often helps advance the instrument. Whenever resist-
tions that can complicate root canal treatment (see ance is met, the file is slightly retracted, rotated, and
chapter 10, Plates 4, 6, and 21). Occasionally, the cur- advanced again until it bypasses the ledge. If the
vature in line with the central beam shows up as a exploring instrument can be introduced to full working
bulls-eye or target at the apex of the root return- length, a radiograph should confirm the return of the
A B
Figure 14-9 Cause and correction of ledge formation in a curved canal. A, A large straight instrument used in a curved canal cuts the ledge
at the curve. B, The ledge may be painstakingly removed with a severely curved file, rasping against the ledge (arrows) in the presence of sodi-
um hypochlorite or a lubricant such as Prolube (Dentsply/Tulsa Dental, Tulsa, Okla.). To bypass the ledge, the tip of a correcting file should
be severely curved to hug the inside wall of the curve.
file to the apical portion of the canal. Subsequent files this mishap. Using instruments with noncutting tips
should be used in the same manner as the exploring file and nickel-titanium files has been shown to be very
to maintain the true pathway. beneficial in maintaining root canal curvatures.
Completion of canal preparation can best be accom-
plished by following these recommendations: Use a Perforations
lubricant, irrigate frequently to remove dentin chips, Accidental canal perforations may be categorized by
maintain a curve on the file tip, and, using short file location. Perforation of the pulp chamber has already
strokes, press the instrument against the canal wall been described (access cavity perforations). Radicular
where the ledge is located (see Figure 14-9, B). The perforations can be identified as either cervical, mid-
canal should be constantly irrigated to wash out dentin root, or apical root perforations.
filings. The tip of the file must be checked repeatedly to Perforations in all of these locations may be caused
be certain that the curve is maintained. If the instru- by two errors of commission: (1) creating a ledge in the
ment is allowed to straighten, it will again catch on the canal wall during initial instrumentation and perforat-
ledge, and repeated filing will lead to deepening of the ing through the side of the root at the point of canal
ledge, or worse, a perforation. The possibility of perfo- obstruction or root curvature and (2) using too large
ration is enhanced by chelation with ethylenedi- or too long an instrument and either perforating
aminetetraacetic acid (EDTA); hence, this medicament directly through the apical foramen or wearing a hole
should not be used in these situations. in the lateral surface of the root by overinstrumenta-
Prevention. The best solution for ledge formation tion (canal stripping).
is prevention. Accurate interpretation of diagnostic
radiographs should be completed before the first Cervical Canal Perforations
instrument is placed in the canal. Awareness of canal The cervical portion of the canal is most often perfo-
morphology is imperative throughout the instrumen- rated during the process of locating and widening the
tation procedure. Finally, precurving instruments and canal orifice or inappropriate use of Gates-Glidden
not forcing them is a sure preventive measure. Failing burs.
to precurve instruments and forcing large files into Recognition often begins with the sudden appear-
curved canals are perhaps the most common causes of ance of blood, which comes from the periodontal liga-
B C
A B
C D
Figure 14-13 Midroot perforation repair. A, The lower first premolar has a midroot buccal perforation. The crown and post have been
removed and the lesion has been sealed with resorbable collagen. B, Using the surgical operating microscope, the perforation has been filled
with Super EBA (Harry J. Bosworth Co. Skokie Ill.). C, Seven-month recall shows evidence of healing. D, Two-year recall with a new restora-
tion in place. (Courtesy of Dr. A. Castellucci, Florence, Italy.)
A B
age owing to inability to properly seal the perforation. Recognition. An apical perforation should be sus-
The reduced prognosis must be considered when evalu- pected if the patient suddenly complains of pain dur-
ating the tooths role in an overall treatment plan. ing treatment, if the canal becomes flooded with hem-
Prevention. Berutti and Fedou have shown how orrhage, or if the tactile resistance of the confines of the
delicate the tooth structure is in these areas. In lower canal space is lost. If any of these occur, it is important
first molars at 1.5 mm below the bifurcation, they to confirm ones suspicions radiographically and
found the dentin of the root to be 1.2 to 1.3 mm thick attempt to correct them before further damage is done.
from the canal to the cementum. The mesiobuccal A paper point inserted to the apex will confirm a sus-
canal is in most danger of being stripped.29 pected apical perforation (Figure 14-15).
There must always have been concern about this Correction. Efforts to repair may be to attempt to
mishap. Peeso, writing as early as 1903, spoke of perfo- renegotiate the apical canal segment or to consider the
rated roots, often caused by a rotary instrument, no perforation site as the new apical opening and then
doubt including the one he designed.30 Two endodon- decide what treatment the untreated apical root segment
tic groups faced this problem and modified prepara- will require. One is now dealing with two foramina: one
tions to avoid these stripping accidents. Endodontics natural, the other iatral. Obturation of both of these
at the University of Southern California (USC) may foramina and of the main body of the canal requires the
have experienced these particular perforations through vertical compacting techniques with heat-softened
their advocacy of Peeso power-driven reamers as an gutta-percha (Figure 14-16). Often surgery is necessary,
auxiliary aid in enlarging the cervical third of the particularly if a lesion is present apically.
preparation.31 To overcome the problem, they devel- Apical perforation can also occur in a perfectly
oped a technique they termed anticurvature filing,32 straight canal if instrument use exceeds the correct
stressing the importance of maintaining mesial pres- working length. This destroys the Resistance Form of
sure on the enlarging instruments to avoid the delicate the root canal preparation at the cementodentinal
danger zone of the distal wall where the root is so junction, making it difficult to control the apical exten-
thin (see Figure 14-11, C). A similar technique was sions of the root canal filling.
advocated at Ohio State University.33 Others reported If the perforation is caused by overinstrumentation,
the same encouraging results.34,35 corrective treatment includes re-establishing tooth
Stripping can be prevented by exercising caution in length short of the original length and then enlarging
two areas: careful use of rotary instruments inside the the canal, with larger instruments, to that length. A
canal and following recommendations for canal prepara- careful adaptation of the primary filling point, often
tion in curved roots, as proposed by the USC group.32 blunted, is imperative. The canal is then cautiously filled
to that length cautiously so that the Resistance Form
Apical Perforations thus created will prevent filling extrusion out the apex.
Perforations in the apical segment of the root canal Creating an apical barrier is another technique that
may be the result of the file not negotiating a curved can be used to prevent overextensions during root
canal or not establishing accurate working length and canal filling. Materials used for developing such barri-
instrumenting beyond the apical confines. Perforation ers include dentin chips,37 calcium hydroxide powder,
of a curved root is the result of ledging, apical trans- Proplast (Vitek Inc. Houston Tex.), hydroxyapatite,38,39
portation, or apical zipping. The glossary of accept- and, more recently, MTA.14 In deciding which material
ed endodontic terminology defines transportation as to use, it is, as with so much in endodontics, more a
removal of canal wall structure on the outside curve in
the apical half of the canal due to the tendency of files
to restore themselves to their original linear shape dur-
ing canal preparation. 36 The term apical zip is also
defined as an elliptical shape that may be formed in
the apical foramen during preparation of a curved
canal when a file extends through the apical foramen
and subsequently transports that outer wall.36 Owing
to their curvatures, the maxillary lateral incisor,
mesiobuccal, and palatal roots of maxillary molars and
the mesial root of mandibular molars are most often Figure 14-15 Location of hemorrhage at the tip of a paper point
the sites of these types of perforations. suggests apical perforation.
B C
question of what works best in the hands of the indi- reviewed iatral and patient-placed foreign objects and
vidual clinician. The solution is often a compromise listed, in addition to the above, nails, pencil lead, tooth-
but is usually preferable to a surgical correction. picks, tomato seeds, hat pins, needles, pins, and other
Prognosis. There are probably more apical perfo- metal objects and advocated use of orthograde ultra-
rations than perforations in other areas of the pulp sonics for removal.40 Most commonly, files and ream-
space. Fortunately, with successful repair, apical perfo- ers are involved in these types of procedural mishaps.
rations have less adverse effect on prognosis than more Usually, the instrument is advanced into the canal until
coronal perforations. it binds, and efforts to remove it then lead to breakage,
Prevention. A detailed discussion addressing the leaving a segment of it in the canal. Other common
prevention of these problems can be found in chapter errors leading to this mishap are using a stressed
10 on instrumentation. instrument (Figure 14-17), placing exaggerated bends
on instruments to negotiate curved canals, and forcing
Separated Instruments and Foreign Objects a file down a canal before the canal has been opened
Many objects have been reported to break or separate sufficiently with the previous, smaller file and then
and subsequently become lodged in root canals. Glass using it in a reaming motion. The result is fracturing of
beads from sterilizers, burs, Gates-Glidden drills, amal- the instrument.
gam, lentulo paste fillers, files and reamers, and tips of Rotary instruments such as Gates-Glidden drills, if
dental instruments have all found their way into canals, stressed, will break close to the shank, leaving a piece
complicating treatment. Chenail and Teplitsky that can be grasped and easily retrieved. The Stieglitz
forceps (Figure 14-18) are especially useful for this. If sonic devices that loosen the fragments and float them
the break occurs closer to the bur head, retrieval is out. Use of ultrasonic devices is advocated in two differ-
much more difficult. ent case reports wherein a tunnel is created around the
Correction. The optimal correction of instrument separated instrument and a sleeve is positioned in the
fracture or the presence of other foreign objects in a canal and around the separated instrument. In one
canal is to remove the obstruction. As a general rule, study, cyanoacrylate is used to bind and remove the
efforts to remove instrument fragments should be made instrument,42 and in the other, a Hedstrom file is wedged
as the initial approach to corrective treatment. in the sleeve until the instrument is locked between the
Ultrasonic fine instruments have proven most effective flutes of the file and the wall of the sleeve.43 The efficacy
in loosening and flushing out broken fragments. Using of these techniques can be judged only on the basis of
microscopy and special fine diamond tips (Figure 14- the few case reports presented and may be attempted
19), a tunnel can be created around the separated instru- with no predictably favorable result. Recently, Hulsmann
ment, which can then be vibrated and dislodged (see reported on the successful use of the Canal Finder
chapter 10). Martin (personal communication to J Ingle, System in combination with ultrasonic devices in
April 1984) and Japanese researchers41 have had remark- bypassing and removing fractured instruments.44 Failing
able success removing broken instruments with ultra- that, one of the following steps may be taken:
A B
Figure 14-19 A, Arrow pointing to a separated rotary instrument in the mesiolingual canal of tooth #30. B, Postobturation film with an
arrow identifying tunneling that was created with an ultrasonic instrument to remove the separated instrument. (Courtesy of Dr. Marshall
Gomes, Lodi, California.)
1. If the instrument fragment is totally within the root instrument fragment is not protruding through the
canal system, one may attempt to bypass it with a apex, further treatment such as apical surgery may
small file or reamer. Often the instruments that break not be necessary. The instrument itself, if embedded
do so along the walls of the canal, being stuck between in the dentin before fragmentation, may help to seal
irregularities of secondary dentin or calcifications. the canal. Studies by Crump and Natkin45 and by
Broken instruments can often be bypassed if the Fox et al.46 have shown that success following instru-
canals are oval or irregular in shape. Bypassing is ment separation is equal to that of teeth without
made easier with a lubricant. If successful, the canal such mishaps.
preparation can be completed and the canal filled 3. If the fragment extends past the apex and efforts to
regardless of whether the instrument segment is remove it nonsurgically are unsuccessful, the correc-
removed during the process of canal preparation. The tive treatment will probably include apical surgery.
instrument segment thus becomes part of the filling The first step, though, will be to complete cleaning,
material. The effort to bypass a broken instrument shaping, and filling the canal, as described above.
has its own risk: possible perforation of the canal. Following that, apical surgery would include
2. If the fragment cannot be bypassed, one can prepare removal of the part of the instrument fragment that
and fill the canal to the level to which instrumenta- extends beyond the apex and retrofilling if indicated
tion can be accomplished. As long as the separated (Figure 14-20).
A B
C D
Figure 14-20 Treatment of a broken instrument past the apex. A, The patient presented with tooth #19 showing a broken file past the apex of
the mesial root (curved arrow) and also a small piece of a broken file in one of the distal canals (small arrow). The small file fragment is within
the root canal system. B, The root canals were re-treated; note that neither broken file could be removed. C, Film showing the result of apical resec-
tion of the mesial root to remove the file fragment extending into the alveolus. No retrofillings were indicated since the canals were adequately
obturated. D, Twelve-month re-evaluation shows satisfactory healing. (Courtesy of Dr. Donald Peters, Loma Linda University, California.)
Prognosis for a tooth with a separated instrument Correction is accomplished by means of recapitula-
may not change very much if the instrument can be tion. Starting with the smallest file used, the quarter-turn
bypassed. If surgical correction is needed, the progno- technique using a chelating agent can be helpful. If the
sis may be reduced, depending on the outcome of cor- blockout occurs at a curve or bend of the root, gently
rective treatment. In any event, it is important to tell precurving the instruments to redirect it is also effective.
the patient about the nature of the procedural mishap, Caution must be employed in attempting to recover
what effect it may have on the prognosis, and what cor- from a blockout occurring at a curve or bend. An all too
rective measures may be needed. common and unfortunate result is the creation of a ledge
Prevention of separation mishaps can be partially and/or lateral perforation. Precurving instruments dur-
accomplished by careful handling of instruments. ing the redirection process and radiographic confirma-
Some instruments, however, will break even with cau- tion are essential.
tious handling and utmost care. As mentioned earlier, a Prognosis depends on the stage of instrumentation
stressed instrument is the one most likely to separate completed when the blockout occurs. If the canal has
in a canal. A stressed instrument, as shown in Figure been adequately cleaned, it should have little or no effect.
14-17, may be recognized by the flutes, which may If, however, the blockout occurs before the canal is clean,
appear unwound. When the spacing appears uneven prognosis will be reduced. Teeth with vital pulps have a
between the cutting edges of a reamer or file, the better prognosis than those with necrotic pulps.
instrument is stressed and should not be used. Small Accidental blockage of the apical end of the canal
instruments, such as Nos. 08, 10, 15, and 20, should be should not be confused with the technique for creating
examined carefully during use to check for signs of an apical stop using dentin chips, as advocated by
stress. Instruments No. 08 and 10 should be used only Marshall49 (see chapter 11). In that technique, dentin
once. These smaller instruments should not be forced chips are purposely placed after cleaning and shaping,
or wedged into a canal; rather, they should be teased and the dentin used is clean. Infected chips and pulpal
gently into place. An instrument that cannot be insert- debris have been shown to deter healing.50
ed to the desired depth should be removed and the tip Prevention consists of frequent irrigation during
modified slightly by bending before resuming the canal preparation to remove dentin debris. The use of
pathfinding process. The use of a canal lubricant will water-soluble lubricants such as File-Eze or K-Y Jelly is
also help. This process may have to be repeated several also a preventive measure.
times before the path of the canal is negotiated.
Two other important points will aid in prevention of OBTURATION-RELATED MISHAPS
separation: sequential instrumentation, using the
quarter-turn technique, and increasing file size only Over- or Underextended Root Canal Fillings
after the current working file fits loosely into the canal Although controversy still may exist regarding apical
without binding. The gradual increase in file sizes, even termination of the root canal filling, there is general
to include the currently available half-sizes, and avoid- agreement that the ideal location is at or near the
ing the rush to finish will go a long way toward pre- dentinocemental junction. A number of studies have
venting mishaps. supported the apical termination of the filling material
just short of the radiographic apex.5154
Canal Blockage Root canal filling material is sometimes inadvertently
When a canal suddenly does not permit a working file to extruded beyond the apical limit of the root canal system,
be advanced to the apical stop, a situation sometimes ending up in the periradicular bone, sinus, or mandibu-
referred to as a blockout has occurred. Buchanan lar canal or even protruding through the cortical plate.
pointed out that blockage occurs when files compact Gross overextensions can lead to symptoms and treat-
apical debris into a hardened mass. He further noted ment failure. A frequent cause of this mishap is apical
that fibrous blockage occurs when vital pulp tissue is perforation with loss of apical constriction against which
compacted and solidified against the apical constric- gutta-percha is compacted. Treatment failure may be less
ture.47 The group at The University of Indiana reported from irritation of the filling material and more from leak-
much the same.48 age around a poorly compacted filling. Roane and associ-
Recognition occurs when the confirmed working ates have attempted to minimize apical canal transporta-
length is no longer attained. Evaluation radiographi- tiona frequent cause of overextrusion of root canal fill-
cally will demonstrate that the file is not near the api- ingby use of the balanced forced approach55,56 (see
cal terminus. chapter 10). The results have been promising.
Underextension of root canal filling material may be sometimes successful if the entire point can be
caused by failure to fit the master gutta-percha point removed with one tug. Many times, however, the
accurately. It can also result from a poorly prepared point will break off, leaving a fragment loose in the
canal, particularly in the apical part of the canal. periradicular tissue. Attempts at removing a laterally
No section addressing overextensions can be consid- condensed overextension, by using chloroform and a
ered complete without the inclusion of extruded Hedstroem file, will usually produce the same results
pastes. Case reports citing materials such as N2,57 as trying to retrieve an overextended thermoplastic
Hydron,58 AH26,59 Diaket,60 and even zinc filling material; it may be pushed further into the
oxideeugenolbased sealers61 have been published. periradicular tissue. If the overextended filling cannot
These articles have shown that, in addition to the be removed through the canal, it will be necessary to
effects of the material, the sequelae and untoward remove the excess surgically if symptoms or radicular
effects are location related. The risk of this occurrence lesions develop or increase in size. Root canal filling
rises in the root canal wherein the apical stop is inade- material such as gutta-percha and many sealers are
quately prepared. Rowe stated that, in teeth with apices generally well tolerated by the surrounding tissues,
approximating the inferior alveolar canal, the most and overextended fillings do not automatically
frequent cause of damage is excess filling material require surgical removal if asymptomatic and not
which has passed through the apices and either caused associated with lesions. If symptoms persist from a
pressure on the neurovascular bundle in the inferior tooth with an overextended gutta-percha filling, sur-
dental canal or produced a neurotoxic effect on the gical removal of the excess material is usually a rela-
nerve trunk62 (Figure 14-21). Overextension of mate- tively minor procedure (Figure 14-22). If the root
rials into the alveolar cancellous bone near other teeth canal has been adequately cleaned and filled, a retro-
that are not close to a sensory nerve can also be expect- filling is not necessary.
ed to produce mild, to moderate, to severe discomfort In re-treatments, the material being removed and the
until the initial inflammatory response subsides. method of removal both affect the potential for overex-
Recognition of an inaccurately placed root canal fill- tension and extent of damage to the surrounding tis-
ing usually takes place when a post-treatment radi- sues. Spngberg studied the effect of various root canal
ograph is examined. filling materials on HeLa cells and found that amalgam,
Correction of an underextended filling is accom- gutta-percha, and zinc phosphate had the least toxic
plished by re-treatment: removal of the old filling fol- effect, followed by calcium hydroxide paste, AH26, and
lowed by proper preparation and obturation of the Tubliseal (Kerr, Orange, Calif.). Chloropercha, Diaket,
canal. Correction of an overextended filling is more and N2 had the strongest toxicity.6366
difficult. An attempt to remove the overextension is Prognosis. The effects of over- or underextensions
on prognosis vary. Endodontic textbooks recommend
that care be used in obtaining good apical seals.67,68
Consequently, if the overextended filling provides an
adequate seal, treatment may still be successful. In cases
of underextended fillings, the prognosis depends on
the presence or absence of a periradicular lesion and
the content of the root canal segment that remains
unfilled. If a lesion is present or the apical canals have
necrotic or infected material in them, the prognosis
diminishes considerably without re-treatment.
Prevention. As with most mishaps, attention to
detail is the best form of prevention. Accurate working
lengths and care to maintain them will help prevent
overextensions. Modifying the obturation technique
may also be preventive. In younger patients with wider
Figure 14-21 Example of the risk in using a paste-type filling root canal systems or in teeth with apical resorption,
material. The root canals in this tooth were filled using a lentulo
the apical stop may not be adequate to prevent
spiral paste filler; note that part of the instrument is still in a canal
(small arrow). More serious is the presence of paraformaldehyde gutta-percha from being extruded. Techniques that cre-
paste in the mandibular canal (open arrow)a consequence of ate apical barriers with calcium hydroxide, dentin
spinning the paste into the root canal with the lentulo paste filler. chips, or MTA may be useful in these cases.
A B
Figure 14-22 Overextended root canal fill-
ing. A, Radiograph shows overextension of
gutta-percha. Symptoms were mild but per-
sistent, so surgical removal of the excess fill-
ing material was done. B, Radiograph shows
the tooth after apical curettage of excess
gutta-percha. No retrofilling was needed. C,
Radiograph shows completed restoration of
the tooth 6 months later; the symptoms sub-
sided after the surgical procedure.
Incorporation of two simple steps into ones root tooth with necrotic pulp. Cohenca and Rotstein report-
canal treatment technique can significantly decrease ed a case wherein endodontic therapy completely
the chance of aberrant fillings; first, confirmation and resolved the patients paresthesia.69 The converse of this,
adherence to canal working length throughout the however, is unfortunately also possible: the endodontic
instrumentation procedure and, second, taking a radi- therapy can cause paresthesia. Overextensions and/or
ograph during the initial phases of the obturation to overinstrumentations are the causative factors most
allow for corrective action, if indicated. often found in paresthesia secondary to orthograde
endodontic therapy.
Nerve Paresthesia Although it is true that most minor overextensions
There have been both local factors and systemic diseases do not require anything more than periodic observa-
reported as causative agents for paresthesia. Local fac- tion, nerve paresthesias or dysesthesias subsequent to
tors in dental-related paresthesias are not limited to gross overextensions of root canalfilling materials do
iatral root canal therapy. Patients presenting with this occur (see Figure 14-21).60,62 The nerve damage may
symptom should routinely be screened for an adjacent be transient or permanent and may be instituted by
overinstrumentation, overextensions, or injury to the cement repairs for furcal perforations have been
inferior alveolar nerve, which is also a potential prob- reported by Alhadainy and Himel.74 The bonding abil-
lem in surgical procedures. Finally, the use of formalde- ity of glass ionomer cement has led other investigators
hyde-containing pastes has been shown to have a high to use it in attempts to repair vertical root fractures. A
incidence of nerve toxicity.70 1-year success was reported in a single case.75 To date,
Correction of these iatral neuropathies is often no consistently successful techniques have been report-
through nonintervention and observation. Gatot and ed to correct this problem.
Tovi suggested the use of systemic prednisone to short- Because this mishap produces irreversible damage to
en the course of the condition, prevent secondary the tooth, it is most important to recognize the causes
fibrosis, and lessen the severity of sequelae.71 Surgical and adjust the techniques that might cause them.
decompression has also been reported, often with Prevention involves avoidance of overpreparing canals
unpredictable results.72 Although specifically address- and the use of a passive, less forceful obturation tech-
ing paresthesia from a surgical procedure, Girard pro- nique and seating of posts. Helfer et al. found a 9% mois-
posed caution in any procedure with the potential of ture loss in pulpless teeth compared with vital teeth.76 As
causing nerve damage: a result of that study, they concluded that endodontically
treated teeth are more brittle. Lewinstein and Grajower,
The most important process the dentist can practice however, found no such increased brittleness.77 Although
is prevention; one should be judicious in his selec- controversy still exists concerning the brittleness,
tion of cases. If another treatment for a problem is Tidmarsh remarked that the change in architecture of an
available, iatral neuropathies can be circumvented endodontically treated tooth required a restoration that
by using it. If there is no alternative treatment and will protect the tooth during function.78 Full cuspal cov-
neural damage is possible, the patient should be erage was recommended.
appropriately advised of the problem before surgery. Vertical root fracture can be attributed to overin-
Explicit written consent signed by the patient and strumentation (overflaring) of the canal, resulting in
witnessed is becoming standard.73 unnecessary removal of dentin along the canal walls,
with subsequent weakening. In Figure 14-8, the result
Vertical Root Fractures of overpreparation combined with pin placement has
Vertical root fractures can occur during different phas- created a situation that could well have been prevented
es of treatment: instrumentation, obturation, and post with more conservative preparation.
placement. In both lateral and vertical condensation
techniques, the risk of fracture is high if too much force
is exerted during compaction. Similarly, during post
placement, if the post is forced apically during seating
or cementation, the risk of fracture is high, particular-
ly if the post is tapered.
Recognition is often unmistakable. The sudden
crunching sound, similar to that referred to as crepitus
in the diseased temporomandibular joint, accompa-
nied with pain reaction on the part of the patient, is a
clear indicator that the root has fractured. A suggestive
teardrop radiolucency may appear in the radiograph
of a long-standing vertical root fracture (Figure 14-23)
and may be associated with only minor symptoms of
soreness in the tooth. To confirm the diagnosis of a ver-
tical fracture, exploratory surgery is a good way to visu-
alize the fracture, but finding a deep periodontal pock-
et of recent origin in a tooth with a long-present root
canal filling is most suggestive of a vertical fracture.
Correction. Unfortunately in most cases of verti-
cal fracture, extraction is the only treatment available at Figure 14-23 Vertical root fracture. Arrows surround the typical
this time. One may speculate that in the future it may halo radiolucency often seen in vertical root fractures. Note the
be possible to glue such fractures. Glass ionomer enormous screw-type post.
A B
Figure 14-24 A and B, Severe tissue emphysema caused by injecting hydrogen peroxide irrigant into tissues. Reproduced with permission
from Bhat KS.84
modified tip and side orifice or the blunt-end Prorinse way of at least 30 mL of sterile water or saline should
(Dentsply/Tulsa Dental, Tulsa, Okla.) will prevent this prevent damage of the sinus lining.92
mishap. Becking reported three cases from Holland, including
In the event that sodium hypochlorite is inadver- an accidental injection through a perforation followed
tently injected into the maxillary sinus, immediate by a severe secondary infection. He warned again that
lavage of the sinus through the same root canal path- the irrigating needle should always be loose in the canal
and that excessive pressure should not be exerted on the
syringe.93 A similar case reported from Israel involved
massive swelling and secondary infection in spite of
postoperative cortisone and antibiotic therapy.86
Hypersensitivity to sodium hypochlorite may occur,
as has been reported from Tel Aviv. A patient reported
a sensitivity to household bleach, and a forearm patch
test confirmed it. Wisely, the dentist chose to use a sub-
stitute irrigant during endodontic therapy.94
Tissue Emphysema
Subcutaneous or periradicular air emphysema is, for-
tunately, relatively uncommon. Tissue space emphyse-
ma has been defined as the passage and collection of
gas in tissue spaces or fascial planes.95 It has been
reported as an untoward event subsequent to various
Figure 14-25 Gross swelling caused by inadvertent injection of dental procedures, such as an amalgam restoration,96
5.25% sodium hypochlorite periradicular to a maxillary premolar. periodontal treatment,97 endodontic treatment,98 and
Demerol poorly controlled the pain. Swelling, pain, and discol-
oration disappeared within 10 days. Reproduced with permission
exodontia.99 The common etiologic factor is com-
from Sabala CL and Powell SE.85 pressed air being forced into the tissue spaces. Two pro-
cedures in endodontics, if carried out improperly, have Endodontic instruments, used in the absence of a rub-
the potential to cause a problem. First, during canal ber dam, can easily be aspirated or swallowed if inad-
preparation, a blast of air to dry the canal, and second, vertently dropped in the mouth. Case reports have
during apical surgery, air from a high-speed drill can been published with reamers or files located in either
lead to air emphysema. Any time a stream of air is the food or air passages. The common denominator in
directed toward exposed soft tissues, the potential for a all is failure to use a rubber dam. The standard of care
problem exists. for endodontic therapy requires the use of a rubber
Recognition. The usual sequence of events is rapid dam. It is not an option to not use it. The all too famil-
swelling, erythema, and crepitus. Hayduk et al. regard iar scenario is the student, taught the technique in den-
crepitus as pathognomonic of tissue space emphysema tal school, who abandons its use in private practice,
and therefore easily distinguished from angioedema.100 supposedly to save time. Practitioners performing
Although pain is not a major complaint, dysphagia101 endodontic therapy without the use of a rubber dam
and dyspnea102 have been reported. Unlike irrigant are placing themselves in unnecessary legal jeopardy.
extrusion reactions, tissue space emphysema remains Thomsen et al. reported an unfortunate result of doing
in the subcutaneous connective tissue and usually does endodontic therapy without the use of a rubber dam
not spread to the deep anatomic spaces.103 Migration (Figure 14-26).110 The patient developed appendicitis
of air into the neck region could cause respiratory dif- from the ingested file and required surgery. It should be
ficulty, and progression into the mediastinum could pointed out that all intraoral procedures involve risks:
cause death. Mejia et al. reported a situation in which a patient swal-
For obvious reasons, the problem should not be lowed a rubber dam clamp that accidentally was
treated lightly. Noble stated, dropped in the mouth. The patient fortunately passed
the clamp successfully, but the report illustrated the
There are several diagnostic signs of mediastinal need for constant care and attention.111
emphysema. First, a sudden swelling of the neck is Recognition in these cases is perhaps better termed
seen. Second, the patient may have difficulty suspicion because sometimes aspiration may not be
breathing and his voice will sound brassy. Third, recognizable. If an instrument aspiration or ingestion
the characteristic crackling can be induced when is apparent, the patient must be taken immediately to a
the swollen regions are palpated. Finally, the medical emergency facility for examination, which
mediastinal crunching noise is heard on ausculta- should include radiographs of the chest and abdomen.
tion, and air spaces are seen in anteroposterior It is also helpful to bring a sample file along so that the
and lateral chest radiographs.104 physician, who may be searching for an instrument in
the alveolar tree, has a better idea of the size and shape
Correction. Treatment recommendations vary of the instrument.
from palliative care and observation to immediate
medical attention if the airway or mediastinum is com-
promised. Broad-spectrum antibiotic coverage is indi-
cated in all cases to prevent the risk of secondary infec-
tion.105 The majority of reported cases have followed a
benign course followed by total recovery.106108
Preventive measures that should be taken to avoid
the risk of this occurrence during endodontic proce-
dures include using paper points to dry root canals. If
the air syringe is to be used, Jerome suggested horizon-
tal positioning over the access opening, using the
Venturi effect to aid in drying the canal.109 In surgi-
cal procedures, once a flap is reflected, apical access can
be made with the slow-speed or high-speed handpieces
that do not direct jets of air into surgery sites.
10. Alhadainy HA, Abdalla AI. Artificial floor technique used for
the repair of furcation perforations: a microleakage study.
JOE 1998;24:33.
11. Mittal M, et al. An evaluation of plaster of Paris barriers used
under various materials to repair furcation perforations (in
vitro study). JOE 1999;25:385.
12. Lee SJ, Monsef M, Torabinejad M. Sealing ability of mineral
trioxide (MT) aggregate for repair of lateral root perfora-
tions. JOE 1993;19:541.
13. Schwartz RS, et al. Mineral trioxide aggregate: a new material
for endodontics. J Am Dent Assoc 1999;130:967.
14. Torabinejad M, et al. Clinical applications of mineral trioxide
Figure 14-27 Routine placement of floss around the rubber dam aggregate. JOE 1999;25:197.
retainer will allow retrieval in the event that the patient aspirates it. 15. Sluyk SR, et al. Evaluation of setting properties and retention
characteristics of mineral trioxide aggregate when used as a
furcation perforation repair material. JOE 1998;24:768.
16. Koh ET, et al. Cellular response to mineral trioxide aggregate.
Correction in the dental operatory is limited to JOE 1998;24:543.
removal of objects that are readily accessible in the 17. Nakata TT, et al. Perforation repair comparing mineral triox-
ide aggregate and amalgam using an anaerobic bacterial
throat. High-volume suction, particularly if fitted with
leakage model. JOE 1998;24:184.
a pharyngeal tip, can be useful in retrieving lost items. 18. Hartwell GR, England MC. Healing of furcation perforations
Hemostats and cotton pliers can also be used. Once in primate teeth after repair with decalcified freeze-dried
aspiration has taken place, timely transport to a med- bone: a longitudinal study. JOE 1993;19:357.
19. Sinai IH. Endodontic perforations: their prognosis and treat-
ical emergency facility is essential. The dentist should ment. J Am Dent Assoc 1977;95:90.
accompany the patient there. 20. Kvinsland I, et al. A clinical and roentgenological study of 55
Prevention can best be accomplished by strict cases of root perforation. Int Endod J 1989;22:75.
adherence to the use of a rubber dam during all phases 21. Fava LRG. One appointment root canal treatment: incidence
of postoperative pain using a modified double-flared tech-
of endodontic therapy. If a rubber dam clamp is placed nique. Int Endod J 1991;24:258.
on the tooth to be treated before rubber dam place- 22. Gutmann JL, Dumsha T. In: Cohen S, Burns R, editors. Pathways
ment, aspiration of a loosened clamp can be avoided by of the pulp. 4th ed. St. Louis: CV Mosby; 1987. p. 170.
attaching floss to the clamp before placement (Figure 23. Fuss Z, et al. Determination of location of root perforations by
electronic apex locators. Oral Surg 1996;82:324.
14-27). 24. Scherer W, Dragoo MR. New subgingival restorative proce-
dures with Geristore resin ionomer. Pract Periodontics
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92. Ehrich DG, Brian JD Jr, Walker WA. Sodium hypochlorite an impacted mandibular third molar. J Am Dent Assoc
accident: inadvertent injections into the maxillary sinus. 1972;84:368.
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Chapter 15
ENDODONTIC CONSIDERATIONS
IN DENTAL TRAUMA
Leif K. Bakland
The outcome of traumatic events involving teeth This chapter contains information both on the
depends on three factors: the extent of injury, the qual- preservation, when indicated, of pulp vitality after a
ity and timeliness of initial care, and the follow-up traumatic injury and the appropriate endodontic inter-
evaluation and care. vention when pulp necrosis is present or expected.
The extent of injury is influenced by the severity of
the traumatic event1 and the presence or absence of pro- ETIOLOGY AND INCIDENCE
tective gear such as mouthguards, face shields, airbags, Sudden impact involving the face or head may result in
and seatbelts.2 Direction of force against the teeth and trauma to the teeth and supporting structures. The
supporting structures and the type of impactblunt or most frequent causes are falling while running, fol-
sharpalso can determine how much tissue damage lowed by traffic accidents, acts of violence, and sports.5
will result. It is well recognized that preventive measures Automobile accidents are often very destructive.
such as tooth and face protection during sporting events One estimate suggests that 20 to 60% of all traffic acci-
and seatbelts and airbags used in cars can significantly dents produce some injury to the facial regions. When
reduce the severity of injuries.2 such injuries involve teeth, avulsions or intrusions are
The quality and timeliness of initial care contribute the most common sequelae.6 Sports activities, both
to a desirable outcome by promoting healing. A good team and individual, can lead to dental injuries, which
example is the avulsed tooth: if it is replanted within have been shown to be common in high school athletes
the first few minutes after avulsion, the prognosis is who do not use mouthguards.7
good, with a high rate of success.3 It is important to The incidence of dental trauma continues to be
note, however, that the quality of initial care also is investigated. A large US study indicated that 25% of the
important. As Andreasen has pointed out, the initial population 6 to 50 years of age may have sustained
treatment should not add more trauma to already traumatic injuries to the anterior teeth.8 Surprisingly,
injured tissues.4 A good example of this principle is some are unaware of their dental injuries, and many
with respect to luxated teeth: the repositioning of dis- choose not to seek dental treatment.
placed teeth and adjacent tissues must be done very Most dental injuries occur during the first two
gently to promote desirable wound healing and long- decades of life. The most accident-prone time period is
term favorable outcome. from ages 8 to 12 years. Frequent dental injuries also
Follow-up evaluation and care are important com- occur from ages 2 to 3 years.5 As might be expected,
ponents of long-term successful outcomes.1 A replant- boys tend to injure their teeth more frequently than
ed avulsed tooth may show an excellent initial girls, by ratios varying from 2:1 to 3:1. One exception is
responsehealing of the severed periodontal liga- in the preschool age, during which time little gender
mentbut if the necrotic pulp is allowed to harbor difference is noted.5 Maxillary central incisors, fol-
bacteria, the resultant root resorption will lead to loss lowed by maxillary lateral incisors and then the
of the tooth. Often the long-term outlook for a trau- mandibular incisors, are the teeth most frequently
matized tooth is related to the response of the tooths involved.5 The most commonly observed dental trau-
pulpthus the importance of endodontic considera- ma involves fracture of enamel, or enamel and dentin,
tions in dental trauma. but without pulp involvement.5
Finally, it is becoming apparent that dental injuries can is also the classification that will be followed in this
result from child abuse or battered child syndrome. The chapter (Table 15-1).
dentist may be the first health care provider to observe
pediatric injuries resulting from abuse. More than half of EXAMINATION
the reported cases of child abuse include evidence of oro- Patients with dental injuries should be examined as
facial trauma. Many of these unfortunate children have soon after the traumatic incident as possible.12,13 The
intraoral injuries, such as tooth and jaw fractures. It is the examination process of trauma patients is similar to the
responsibility of all professionals to report suspected regular examination of all endodontic patients, as
cases of child abuse or neglect.9 described in chapter 6. However, owing to the possibili-
The following observations have been recommend- ty of concomitant injury to adjacent tissues and the fre-
ed as possible indicators of an abused child; none, how- quent need to provide insurance and/or a legal report, it
ever, are pathognomonic, and the absence of any of is prudent to pay particular attention to a careful exam-
them does not preclude the diagnosis of abuse10: ination and recording of clinical findings. For that rea-
son, the following sections have been given emphasis.
1. There is a delay in seeking medical (dental) help (or
help is not sought at all). History
2. The story of the accident is vague, is lacking in The clinical dental history is primarily the subjective
detail, and may vary with each telling and from per- statement by the patient. It includes the chief com-
son to person. plaint, history of the present illness (injury), and perti-
3. The account of the accident is not compatible with nent medical history.
the injury observed.
4. The parents mood is abnormal. Normal parents are Chief Complaint
full of creative anxiety for the child, whereas abusing The chief complaint may appear obvious in traumatic
parents tend to be more preoccupied with their own injuries. However, the patient should be asked about
problemsfor example, how they can return home severe pain and other significant symptoms. A bloody
as soon as possible. lip appears more dramatic, but a concomitant broken
5. The parents behavior gives cause for concernfor
example, they may become hostile and rebut accusa-
tions that have not been made. Table 15-1 Dentofacial Injuries
6. The childs appearance and interaction with the par-
Soft tissues
ents are abnormal. The child may look sad, with-
Lacerations
drawn, or frightened.
Contusions
7. The child may say something concerning the injury
Abrasions
that is different from the parents story.
Tooth fractures
Most hospitals have personnel who can offer advice Enamel fractures
to health care providers unsure about how to report Crown fracturesuncomplicated (no pulp exposure)
suspected abuse. Crown fracturescomplicated (with pulp exposure)
Crown-root fractures
CLASSIFICATION Root fractures
The purpose of classifying dental injuries is to pro- Luxation injuries
vide a description of specific conditions, allowing Tooth concussion
dentists to recognize and treat using recommended Subluxation
treatment remedies. It also allows data collection Extrusive luxation
worldwide to monitor many aspects of dental trau- Lateral luxation
matology: etiology, incidence, and treatment out- Intrusive luxation
come. The currently recommended classification is Avulsion
one based on the World Health Organization classifi-
Facial skeletal injuries
cation of diseases and modified by Andreasen and
Alveolar processmaxilla/mandible
Andreasen. 5 This classification is used by the
Body of maxillary/mandibular bone
International Association of Dental Traumatology
Temporomandibular joint
and is preferred over previous outdated systems.11 It
jaw may produce more pain and must be considered a interference are the most commonly reported symp-
higher priority. The chief complaint may include sever- toms. In addition, the patient should be asked about
al subjective symptoms, and these should be listed in any symptoms from adjacent soft tissues such as
order of importance to the patient. Also note the dura- tongue, lips, cheeks, gingiva, and alveolar mucosa.
tion of each symptom.
Medical History
History of Present Illness (Injury) The following aspects of the medical history are
Obtain information about the accident in chronologic emphasized for their importance in trauma cases:
order and determine what effect it has had on the
patient. Note any treatment before this examination 1. Allergic reactions to medications. Because both
and question the patient about previous injuries antibiotics and analgesics are frequently prescribed
involving the same area. The information can be gath- for trauma patients, it is necessary to know if the
ered by using questions such as the following: patient can tolerate the prescribed medication.
2. Disorders, such as bleeding problems, diabetes, and
When and where did the injury happen? Record the epilepsy. These are only some of the many physical
time and date as closely as the patient can recall. and medical conditions that may affect the manage-
Note the location, for example, playground, car acci- ment of a trauma patient. Because patients with
dent, etc. All of this may be highly pertinent if legal medical problems sometimes neglect to note such a
or insurance problems later develop. disorder on the questionnaire, the dentist may have
How did the injury happen? This question can pro- to question in more depth. Patients suffering from
vide important information. A blow to the face by a grand mal epilepsy, for example, may have telltale
blunt object, such as a fist, often produces a different
chipped or fractured teeth that were injured during
injury than if the chin is hit during a car accident or
seizures.
if the patient falls off a bicycle.14 Further, since chil-
3. Current medications. To avoid unwanted drug
dren with battered child syndrome may be seen, a
interactions, the dentist must know which drugs the
high degree of suspicion should be maintained in
patient is currently taking, including over-the-
cases with a marked discrepancy between the clinical
counter medications.
findings and the history supplied by the parent or
4. Tetanus immunization status. For clean wounds, no
guardian.10,11
Have you had treatment elsewhere before coming booster dose is needed if no more than 10 years have
here? Prior treatment affects both the treatment elapsed since the last dose. For contaminated
plan and the prognosis. If the tooth was avulsed, was wounds, a booster dose should be given if more than
it replanted immediately or how soon after the acci- 5 years have elapsed since the last dose.15
dent? Was it washed? Clinical Examination
Have you had similar injuries before? Repeated
injuries to teeth affect the pulps and their ability to A careful, methodical approach to the clinical examina-
recover from trauma. Previous trauma may also tion will reduce the possibility of overlooking or miss-
explain clinical findings not in harmony with the ing important details. The following areas should be
description of the most recent injury. This is partic- examined.
ularly true of abused children.
Soft Tissues
Have you noticed any other symptoms since the
injury? This type of question can provide very useful Soft tissue trauma, for the most part, is not covered in
information about the possible effects of the injury on this chapter, at least not in regard to treatment, such as
the nervous system. Signs and symptoms to watch for suturing. It is important, however, to examine all soft
are dizziness; vomiting; severe headaches; seizures or tissue injuries because it is not unusual for tooth frag-
convulsions; blurred vision; unconsciousness; loss of ments to be buried in the lips. The radiographic exam-
smell, taste, hearing, sight, or balance; or bleeding ination should include specific exposures of the lips
from the nose or ears. Affirmative response to any of and cheeks if lacerations and fractured teeth are pres-
the above indicates the need for emergency medical ent (Figure 15-1). In any event, all areas of soft tissue
evaluation.12 injury should be noted, and the lips, cheeks, and tongue
What specific problems have you had with the trau- adjacent to any fractured teeth should be carefully
matized tooth/teeth? Pain, mobility, and occlusal examined and palpated.
the proximity of the fracture to the crown. The degree for some time. But when the pulp recovers, its sensitiv-
of mobility can be recorded as follows: 0 for no mobil- ity to the EPT gradually returns. Such recovery can be
ity, 1 for slight mobility, 2 for marked mobility, and 3 monitored with the test. Other times, the pulp later
for mobility and depressibility. Examine for and record becomes necrotic after initially responding positively
the depths of any periodontal pockets. or even after apparent recovery from the initial injury.
The EPT can provide much useful information if its
Displacement advantages, as well as its limitations, are considered.
Note any displacement of the teeth that may be intru- Cold stimulus in the form of carbon dioxide or ice is
sive, extrusive, or lateral (either labial or lingual) or used extensively for pulp testing and is quite reliable.
complete avulsion. Sometimes the change is minimal, The response, however, is not easily quantified. The
and the patient should be asked about any occlusal usefulness of cold is most applicable in differentiating
interference that developed suddenly. In occlusal between reversible and irreversible pulpitis. Hot stimu-
changes, consider the possibility of jaw or root frac- lus has limited use in pulp testing traumatically injured
tures or extrusions. teeth. However, subjective symptoms can be useful,
particularly a history of spontaneous pain, indicating
Injury to Periodontal Ligament and Alveolus irreversibility.
The presence and extent of injury to the periodontal Discoloration, particularly a grayish hue, involving
ligament and supporting alveolus can be evaluated by permanent teeth is indicative of pulp necrosis, whereas
tooth percussion. Include all teeth suspected of having a yellowish hue means that extensive calcification has
been injured and several adjacent and opposing ones. occurred. The latter is not necessarily associated with
The results may be recorded as normal response, irreversible pulpitis or pulp necrosis.16,17
slightly sensitive, or very sensitive to percussion.
Careful tapping with a mirror handle is generally satis- Radiographic Examination
factory. In cases of extensive apical periodontal dam- Radiography is indispensable in the diagnosis and
age, however, it may be advisable to use no more than a treatment of dental trauma. Detection of dislocations,
fingertip for percussion. Normal, noninvolved teeth root fractures, and jaw fractures can be made by radi-
should be included for comparison. ographic examination. Extraoral radiography is indi-
In impact trauma with no fractures or displacement, cated in jaw and condylar fractures or when one sus-
the percussion test is very important. In some appar- pects trauma to the succedaneous permanent teeth by
ently undamaged teeth, the neurovascular bundle, intruded primary teeth. Soft tissue radiographic evalu-
entering the apical canal, may have been damaged, and ation is indicated when tooth fragments or possible
the possibility of subsequent pulp degeneration exists. foreign objects may have been displaced into the lips,
Such teeth are often sensitive to percussion. for example see Figure 15-1. The film should be placed
between the lip and the jaw, and short exposure at min-
Pulpal Trauma imal KVP is advocated.12
The condition of the dental pulp should be evaluated The size of the pulp chamber and the root canal, the
both initially and at various times following the trau- apical root development, and the appearance of the
matic incident. The response of the pulp to trauma periodontal ligament space may all be evaluated by
largely determines the treatment of and prognosis for intraoral radiographs. Such films are of prime impor-
injured teeth. Often the initial treatment may be no tance both immediately after injury and for follow-up
treatment but rather monitoring of the pulp response. evaluation.18 Changes in the pulp space, both resorp-
Pulps may deteriorate and become necrotic months or tive and calcific, may suggest pulp degeneration and
years after the original trauma, so periodic re-evalua- indicate therapeutic intervention (Figure 15-2). Other
tion is important in the management of dental radiographic views may be indicated in more extensive
injuries.1 injuries than those confined to the dentition. Finally, it
Several means of evaluating traumatized pulps are is also important to carefully file all radiographs for
available.1,12 The electric pulp test (EPT) has been future references and comparisons.
shown as reliable in determining pulpal status, that is,
in differentiating between vital and necrotic pulps. The Follow-up Evaluation
EPT should be used, and the results recorded, at the Trauma patients should be evaluated often enough,
initial visit and at subsequent recall visits. Often, after and over a long enough period of time, either to deter-
an impact injury, the pulp does not respond to the EPT mine that complete recovery has taken place or to
A
Figure 15-2 Subsequent to trauma one central incisor (a) shows
pulpal calcification, whereas the adjacent one (b) undergoes inter-
nal resorption (arrow). The latter requires endodontic intervention,
whereas pulpal calcification in and of itself does not.
A A
B B
Figure 15-4 Maxillary left central incisor developed an apical abscess Figure 15-5 A, Fistulous tract traced with gutta-percha point
30 years after a traumatic basketball accident. A, Note labial swelling from labial orifice to B, apical lesion.
(open arrows) and B, apical radiolucency. Pulp did not respond to an
electric pulp test, and the crown was slightly discolored.
and pulp necrosis not related to other obvious causes Tooth Fractures
such as caries and/or tooth infractions. Sinus tracts are This category of injuries includes all fractures from
sometimes the first indication of a previous injury; enamel infractions to complicated crown-root frac-
these tracts should be traced to identify areas of origin tures. They are the most commonly reported types of
(Figure 15-5). dental injuries, with an incidence of 4 to 5% of the
population (United States)8,20 accounting for over one-
TRAUMATIC INJURIES
third of all dental trauma.21
Soft Tissue Injuries
Description. Injuries to oral soft tissues can be lacer- Enamel Fractures
ations, contusions, or abrasions of the epithelial layer or a Description. Enamel fractures include chips and
combination of injuries.1 If treatment is indicated, it con- cracks confined to the enamel and not crossing the
sists of controlling bleeding, repositioning displaced tis- enamel-dentin border. These enamel infractions22 can
sues, and suturing. Oral soft tissues heal rather quickly. be seen by indirect light or transillumination or by the
Crown FracturesUncomplicated
(No Pulp Exposure) A
Description. Crown fractures involving enamel
and dentin without pulp exposure are called uncompli-
cated crown fractures by Andreasen5 and Class 2 frac-
tures by Ellis.23 They may include incisal-proximal cor-
ners, incisal edges or lingual chisel-type fractures in
anterior teeth, and, frequently, cusps in posterior teeth.
Cusp fractures in posterior teeth are often related to
blows to the face. Because anterior teeth are more often
involved in traumatic injuries, the description in this
chapter will refer only to these teeth.
Crown fractures that expose dentinal tubules may
potentially lead to contamination and inflammation of
the pulp. The outcome may be either formation of irri-
tational dentin or pulp necrosis. Which outcome
occurs depends on a number of factors: proximity of
the fracture to the pulp, surface area of dentin exposed,
age of the patient (pulp recession and size of dentinal
tubules), concomitant injury to the pulps blood sup-
ply, length of time between trauma and treatment, and
possibly the type of initial treatment performed.1, 22
Incidence. The enamel/dentin type of crown frac-
ture is a very common type of injury; a distinction,
however, is not always made between fractures involv-
ing only enamel and those involving both enamel and
B
dentin. The two groups together certainly comprise the
vast majority of dental injury cases.8,20,21 Figure 15-6 Sequelae to injury that initially produced only an
Diagnosis. The diagnosis of crown fracture with- enamel fracture, A, but includes, in part B, pulpal necrosis, arrested
out pulp involvement is made by clinical examination root development, and apical periodontitis. Note crown discol-
oration in A, visible in transmitted light (arrow)
with a mirror and an explorer. In addition, it is also
important to determine the status of the pulp and peri-
radicular tissues by the usual examination procedures.
Treatment. The primary goal of treatment in teeth
with crown fractures is to protect the pulp by sealing ed restorations. Placement of unsightly stainless steel
the dentinal tubules.24 The most effective method is by or temporary acrylic crowns is now a thing of the past
direct application of dentin bonding agents and bond- for enamel/dentin fractures.
If the fractured crown fragment is available, it is often and coronal fragment. Carefully re-insert the fragment
advantageous to use it to restore the tooth. The tech- onto the tooth, taking care that the path of insertion is
nique for reattachment (Figure 15-7) is as follows2527: correct. Remove excess resin and apply the curing light
Anesthetize the tooth and place a rubber dam to iso- circumferentially. (Alternatively, a dual-cure resin lut-
late the tooth. Clean the tooth segment and fractured ing agent may be used.) Polish the resin and check the
tooth with pumice and water. Determine the reattach- orclusion, which can be adjusted if necessary.
ment path of insertion, using a sticky wax handle to The expected outcome is usually good, although
hold the coronal fragment. Care should be taken to resistance to refracture is about 50% less than an intact
accurately refit the fragment since it can easily be mis- tooths resistance.25
aligned anteroposteriorly. Apply a suitable etchant, Early treatment of crown fractures is desirable. The
according to its manufacturers directions, to both the length of time between injury and treatment has a
tooth and the coronal segment extending 2 mm beyond direct adverse effect on the pulps ability to survive.
the cavosurface margins. Rinse well. Apply a dentinal The closeness of the fracture to the pulp and the size
primer followed by application of an unfilled resin. of the dentinal tubules also have a bearing on the
Next, dilute a light-cured composite resin with unfilled pulps continued vitality, the latter being significant in
resin to a creamy consistency and apply it to the tooth young patients.1,22
A B
C D
Figure 15-7 A, Uncomplicated fracture, central incisor. The dentin has been temporarily covered with glass ionomer. B, Radiograph, show-
ing fracture with incisal glass ionomer. C, The incisal tooth fragment, which had been kept in water for several days, has been bonded to the
tooth after removal of the glass ionomer. D, The tooth as it appears 212 years after incisal fragment reattachment. (Courtesy of Dr. Mitsuhiro
Tsukiboshi.)
Follow-up and Prognosis. As with most traumatic Treatment planning is influenced by tooth maturity
injuries, patients with crown fractures need to be re- and extent of fracture. Every effort must be made to
evaluated periodically to determine pulpal status. preserve pulps in immature teeth. Conversely, in
Traumatized teeth can develop pulp necrosis some mature teeth with extensive loss of tooth structure,
time after the initial injury, and if necrosis occurs, pulp extirpation and root canal therapy are prudent
endodontic therapy is indicated.22 before post/core and crown restoration.
The prognosis is usually good for teeth with crown Pulp preservation by vital pulp therapy includes pulp
fractures in which the pulps are not exposed.1,22 The capping and pulpotomy. Both procedures permit preser-
unpredictable part is determining the extent of con- vation of pulp tissue for continued root development.
comitant pulp injury. Pulp capping is a time-honored procedure that is
Primary Teeth. Crown fractures are rare in the sometimes quite successful. However, in recent years, a
primary dentition, but when they occur, the pulps are modified pulpotomy technique (Cvek type)29 has
exposed more often than in the permanent dentition. shown itself to be more predictable. This pulpotomy
When the pulps are not exposed, treatment consists of technique may be termed shallow pulpotomy in con-
smoothing rough edges or repairing with composite trast to the older method of removing coronal pulp tis-
resin by the acid-etch technique.22 sue deeply to the cervical, or deeper, level. The deep
pulpotomy techniques were difficult technically and
Crown FracturesComplicated failed to deliver what vital pulp therapy should: preser-
(With Pulp Exposure) vation of pulp tissue in the critical cervical area of the
Description. Crown fractures involving enamel, tooth, where subsequent fractures can occur in thin,
dentin, and pulp are called complicated crown frac- weak walls of pulpless teeth.
tures by Andreasen and Andreasen22 and Class 3 frac- The procedure for shallow pulpotomy (also referred
tures by Ellis and Davey.23 The degree of pulp involve- to as a partial or Cvek-type pulpotomy) can be per-
ment varies from a pinpoint exposure to a total unroof- formed by any well-trained dentist30,31 (Figures 15-8
ing of the coronal pulp. and 15-9). After anesthesia and rubber dam isolation,
The exposure of the pulp in complicated crown frac- remove granulation tissue from the exposure site using
tures makes the treatment more difficult. Bacterial con- a spoon excavator. This permits evaluation of the size
tamination of the pulp precludes healing and repair of exposure. Next, with a water-cooled, round diamond
unless the exposure can be covered to prevent further stone, remove pulp tissue from the pulp proper, to a
contamination. The initial reaction is hemorrhage at the depth of 1 to 2 mm. Visualize the removal, layer by
site of the pulp wound. Next, a superficial inflammatory layer, rather than a quick cut with the stone. Allow
response occurs, followed by either a destructive plenty of coolant water spray to irrigate and prevent
(necrotic) or proliferative (pulp polyp) reaction.28 heat damage to the subjacent pulp tissue.
Incidence. It is fortunate, considering the treat- After preparing the pulp tissue, rinse the wound with
ment complications, that crown fractures exposing the saline and allow the bleeding to stop (a cotton pellet
pulps are far less common than those not involving the moistened with saline can be used to control the bleed-
pulp. The incidence, compared with all types of dental ing), then wash the wound gently with saline, and it is
injuries, ranges from 2 to 13%.22 ready for coverage with a calcium hydroxide material.
Diagnosis. The diagnosis of crown fracture with Apply the calcium hydroxide over the wound and
pulp involvement can be made by clinical observation. also cover all exposed adjacent dentin. A hard-setting
In addition, it is important to determine the condition calcium hydroxide such as Dycal (Dentsply/Caulk,
of the pulp. If the tooth has been luxated in addition to Tulsa, Okla.) is easy to use. Next, an intermediate base
the crown fracture, pulpal recovery is compromised, of hard-setting zinc phosphate cement or glass
and the longer the pulp is exposed before being pro- ionomer cement is placed before restoring with dentin
tected, the poorer the prognosis for pulpal survival.22 adhesive and composite resin.
Treatment. Traditionally, these injuries have often After radiographic evidence of mineralization of
resulted in automatic pulp extirpation, even in young, the exposed pulpal area, it is recommended that the
developing teeth. Such drastic measures are not always initial filling and liner be replaced to prevent
necessary; vital pulp therapy preserves the potential for microleakage. This may occur 6 to 12 months after the
continued root developmentan important consider- initial treatment.29,30
ation in a tooth with a thin, weak root structure owing An alternative to the use of calcium hydroxide is a
to a lack of complete tooth development. new material, mineral trioxide aggregate (MTA)
A B
C D
Figure 15-8 Shallow pulpotomy. A, Crown fracture exposes pulp. B, Remove pulp tissue with a round diamond bur to a depth of about
2 mm; use water spray to cool the diamond. C, After bleeding has stopped, wash the pulp wound with saline and apply a calcium hydrox-
ide liner on top of which a base must be placed. The base can be glass ionomer cement. D, The lost tooth structure is replaced with acid-
etched composite resin.
E F
Figure 15-9 A, Crown fracture exposing pulp. B, Patients age (10 years) and stage of root development (open apex) indicate need for
perserving radicular pulp. C and D, Pulpotomy and calcium hydroxide to cervical level. E, Acid-etched composite restoration. (Restoration
by Dr. James Dunn.) F, Radiograph taken years after accident. Note continued root development (arrow).
(ProRoot MTA, Tulsa Dental/Dentsply, Tulsa, Okla.), the pulp proper. Bleeding is allowed to stop (which
which has found many uses in endodontics.32 It has usually takes 2 to 3 minutes) before MTA is placed
been shown to be very effective in vital pulp thera- directly into the pulp wound. The presence of a
py3336 (Figure 15-10). small amount of blood in the wound area is not a
The technique for managing a traumatic pulp expo- contraindication to placing MTA; in fact, some
sure using MTA is in many ways similar to that used with moisture is required for the proper curing of the
calcium hydroxide, with some minor modifications: material.
4. Since access is not a problem when performing a
1. The tooth must be anesthetized and should be iso- shallow pulpotomy, the placement of MTA is not as
lated with a rubber dam. difficult as it often can be when used for other pur-
2. The tooth, fractured surface, and wound area should poses, such as repair of perforations. The mixture of
be disinfected using a solution such as sodium MTA powder and liquid should be of such a consis-
hypochlorite. tency that it can be carried from the mixing pad to
3. A shallow pulpotomy is done to provide space for the pulp wound using a dental instrument such as a
the MTA. A round diamond stone is used in a high- spoon excavator. A small amount of MTA should be
speed handpiece with water irrigation to remove placed on the wound surface and gently tapped with
exposed pulp tissue to a depth of at least 2 mm into a moist cotton pellet so that it covers the exposed
B C D
pulp. Next, the entire access into the pulp should be With respect to the length of time pulp tissue can be
filled in a similar manner using small amounts of exposed and still permit vital pulp therapy to be per-
MTA. Any excess moisture should be removed from formed, studies by Heide28 and Cvek29 indicate that it
the surface of the MTA using a dry cotton pellet. may be safe to proceed with shallow pulpotomies up to
5. The rubber dam can then be removed, and the 1 week post fracture. After that, it is probably question-
patient can be dismissed. Leaving the MTA exposed able in mature, fully formed teeth, although in young,
to saliva will allow it to cure. A minimum of 6 hours developing teeth with wide-open apices, it is worth
should be allowed for the material to adequately attempting to save pulps even when they have been
cure, but clinical experience indicates that waiting at exposed for more than a week. The goal is to promote
least 24 hours is better. The tooth can then be continued root formation.
restored with a definitive restoration. Follow-up and Prognosis. A number of studies
have evaluated the prognosis of traumatized anterior
Previous research34,35 has shown that the pulp teeth, including those with crown fractures.3943 The
responds favorably to the protection provided by an MTA teeth need periodic evaluation, radiographically and
layer. The reparative dentin is consistently more uniform clinically, to determine pulpal status. Discoloration
and thicker under MTA compared with calcium hydrox- associated with the interphase between tooth structure
ide. As has been convincingly demonstrated,37 the pulp and bonded resin material may indicate microleakage,
can tolerate almost any dental material and produce new and the restoration should be replaced to prevent bac-
dentin as long as it can be protected against microleakage, terial contamination of the exposure site. Acceptable
a function that MTA appears to perform better than any results of evaluation following pulpotomy should be all
material with which it has been compared. of the following42:
The differences in the vital pulp therapy technique
when MTA is used in place of calcium hydroxide are 1. No clinical signs or symptoms
important to consider. First, it is not important that the 2. No evidence of periradicular pathologic changes
pulp wound bleeding be completely stopped prior to 3. No evidence of resorption, either internal or external
placing the MTA; in fact, the presence of a small 4. Evidence of continued root formation in developing
amount of blood provides necessary moisture for cur- teeth
ing of the material and has been shown to work as well
as any other fluid.38 Second, since the MTA needs to Evidence of root canal obliteration by calcified tissue
cure prior to placement of a definitive restoration, it is is often taken as a sign of pulp degeneration. Lumen
necessary to schedule two appointments for this proce- reduction can be seen years after trauma and treat-
dure: the first to perform the shallow pulpotomy and ment,44,45 but such calcification is not necessarily an
place the MTA on the pulp wound and the second to indication of pulp necrosis.45 The decision to intervene
complete the restoration after the material has cured. endodontically in cases of apparent pulp space calcifi-
Future material development may be expected to result cation should be based on evidence of pulp necrosis
in a faster-curing MTA. Third, it is not necessary to re- and not on pulp calcification.
enter the pulpotomy site later to remove the pulp cap- If root canal treatment has been performed, either
ping material, as has been recommended for calcium immediately after the injury or subsequent to pulp cap-
hydroxide pulpotomies.29,30 Mineral trioxide aggregate ping or pulpotomy, follow-up evaluation of healing
does not appear to deteriorate and disintegrate with should be done, particularly if luxation of the tooth
time; thus, space for microleakage does not develop as occurred, to monitor for possible root resorption.1
it does with calcium hydroxide. Primary Teeth. Crown fractures involving the
In mature, fully developed teeth, particularly those pulp are not common in the primary dentition.46
treatment planned for full-crown coverage, conven- When such injuries occur, pulpotomies or pulpec-
tional root canal therapy is the treatment of choice. It tomies may be considered. Pulp capping is generally
should be pointed out that shallow pulpotomies can be not successful in primary teeth, and endodontic treat-
performed in mature teeth, thus preserving pulp tissue ment is difficult owing to the tortuous and fine canal
and accomplishing repair quite conservatively. But it structure. Patient management is a further complicat-
should probably be reserved for instances of crown ing factor in treating fractured primary teeth. The
fractures in which the fractured segment can be result of poor cooperation is often tooth extraction.47
restored with composite resin or when rebonding of Pulpotomy is indicated when the pulp is still healthy
the fractures segment is possible. and pulpectomy when the pulp is not expected to
recover. The procedures are the same as described The vertical fracture of endodontically treated teeth
above for the permanent dentition, except that the root is an additional type of crown-root fracture involving
canal filling material should be a resorbable cement both anterior and posterior teeth (Figure 15-13). Most
such as zinc oxideeugenol. For additional details, see appear to be caused by the endodontic treatment itself
chapter 17. or by subsequent inlay or dowel placement49 (see
Chapters 13 and 19).
Crown-Root Fractures Incidence. Crown-root fractures per se are not
In these fractures, enamel, dentin, and cementum are generally recognized as a separate entity, and little
involved. If the pulp is also involved, the case is consid- information is available about their frequency of
ered more complicated. occurrence. Andreasen and Andreasen reported a 5%
Description. Crown-root fractures in anterior incidence of total dental injuries.48 However, when one
teeth are usually caused by direct trauma.48 This may includes the so-called cracked tooth syndrome and ver-
result in a chisel-type fracture, with the apical extent of tical fractures of endodontically treated teeth (all are
the fracture below the lingual gingiva (Figure 15-11). caused by trauma in one form or another), the total
These fragments may be single or multiple, leaving the incidence may be higher. For additional information,
fragment or fragments loose and attached only by peri- see chapter 13.
odontal ligament fibers (Figure 15-12). The pulp may Diagnosis. Crown-root fractures result in com-
also be involved, depending on the depth of fracture plaints of pain, particularly when the loose fragment or
into the dentin, further complicating a difficult trau- fragments are manipulated. The fragments are general-
matic injury. ly easy to move, and bleeding from the periodontal lig-
In posterior teeth, the causes of crown-root fractures ament or pulp often fills the fracture line. Because of
have been attributed to indirect trauma including the mobile parts, percussion is seldom useful in deter-
large-size restorations, thermal cycling, high-speed mining apical periodontal involvement. However, that
instrumentation, pin placement, and direct trauma, may be done later, after removal of the loose fragments.
such as accidental blows to the face and jaws. The role Unless the pulp is exposed, EPT should be performed
of restorative procedures is not well understood, par- on the injured and adjacent teeth.
ticularly in regard to occlusal restoration size and Radiographs of anterior crown-root fractures are
resultant fractures.49 often difficult to interpret. It is very important to take
As in anterior teeth, two types of crown-root frac- more than one angulation to assess the extent of frac-
tures are recognized in posterior teeth: those with and tures. Angulations of films should include both addi-
those without pulpal involvement. tional horizontal and vertical angulations.
A B
Figure 15-11 A, Crown-root fracture of the chisel type extending below the alveolar crest palatally. B, Such teeth may be orthodontically
extruded for restorative reasons.
A B
Figure 5-12 Crown-root fracture with pulp exposure. A, Note loose mesial crown fragments, which are attached by periodontal ligament
fibers. B, After anesthesia, loose fragments are removed and rubber dam applied. Note exposure of radicular pulp (arrow). C, The remain-
der of coronal pulp tissue is amputated and the surface of pulp allowed to coagulate. Cotton pellet (CP) aids by controlling initial bleeding.
D, After surface coagulation, the area is irrigated and calcium hydroxide placed directly over pulp tissue. It helps to prepare a shelf around
the pulp orifice to support the base and prevent the cement from being pushed into the underlying pulp tissue (arrows point to shelf in
dentin). E, After placement of base, acid-etched composite will be used for final restoration.
A
Figure 15-13 Vertical root fracture of an endodontically treated tooth. A,
Radiograph shows characteristic drooping lesion (arrows) around the root of a pre-
molar with a very large diameter but short post. B, Photograph shows vertical frac-
ture of the root (black arrow). B
Posterior crown-root fractures may be very difficult If the pulp is not initially involved, its continued
to diagnose because they are more inconspicuous. The vitality depends on ones ability to protect it from con-
examination and diagnosis of cracked tooth syndrome tamination. If possible, the condition of the pulp
are discussed in chapters 6 and 7. should be evaluated for a sufficient period of time to
Treatment. There are several treatment options detect necrosis should it occur.
available for crown-root fractures, depending on the Primary Teeth. Fractures involving crowns and
extent of the fracture.1 If the fragment can be reat- roots of primary teeth occur infrequently, and when
tached by bonding, and no pulp exposure has occurred, they do, extraction is indicated.48
that is the most conservative and convenient approach.
If pulp exposure has resulted from the fracture (see Root Fractures
Figure 15-12), either a shallow pulpotomy procedure This type of fracture involves the roots only: cemen-
(if the tooth is still developing) or root canal treatment tum, dentin, and pulp (Figure 15-16).
(fully developed teeth) must be done prior to any Incidence and Description. Intra-alveolar root
rebonding or crown restoration.50 fractures do not occur frequently compared with other
Crown-root fractures extending well below the alve- dental injuries and account for probably less than 3%
olar crest may require surgical repositioning of the tis- of all dental trauma. These fractures are generally
sues to expose the level of fracture. Long-term esthet- transverse to oblique and may be single or multiple,
ic problems may, however, result from such surgical complete or incomplete.53 Incompletely formed roots
procedures.1 rarely fracture, but when they do, the prognosis is usu-
Extrusioneither surgical51 or orthodontic52can ally very good.54
also be done to allow better restoration of the fractured Diagnosis. Root fractures are not always horizon-
tooth. See Figures 15-14 and 15-15 for illustrations of tal; in fact, probably more often than not, the angula-
orthodontic extrusion. tion of fractures is diagonal (Figure 15-17). This fact
Prognosis and Follow-up. The quality of the probably explains why root fractures are often missed
restorative procedure is an important factor in deter- radiographically. With the conventional 90-degree-
mining the long-term success of treating crown-root angulation periradicular x-ray film, if the fracture is
fractures. Both the loss of significant tooth structure diagonal, it is very likely that it will be missed. Only
and often the difficulty in restoring normal crown con- when the x-ray beam can pass directly through the
tour contribute to a guarded prognosis. fracture line does it show on the radiograph. It is there-
A B C
E F
G H
Figure 15-14 Basic technique for root extrusion. A, Root fracture at or below crestal bone. B, Root canal therapy completed. C,
Cementation of a post-hook. D, Occlusal view; horizontal wire is bent to cross midline of the tooth to be extruded. Wire is embedded with
acid-etched composite on adjacent teeth. E, Elastic is attached to activate extrusion. F, When satisfactory extrusion has been completed, the
tooth is stabilized until periodontal and bony repair are complete. G, Periodontal and bony repair completed. H, Permanent restoration. (See
also Figure 15-15.)
fore imperative to take additional film angulations (Figure 15-18). If the coronal fragment is mobile, treat-
when root fracture is suspected.53 ment is indicated. The initial treatment consists of
One additional film angulation (foreshortened or 45 repositioning the coronal segment (if it is displaced)
degrees) will, when combined with the standard 90- and then stabilizing the tooth to allow healing of the
degree positioning, reveal most of the traumatic root periodontal ligament supporting the coronal seg-
fractures.55 ment53 (Figure 15-19).
Treatment. If there is no mobility and the tooth is Repositioning can be as simple as pushing the tooth
symptomless, the fracture is likely to be in the apical into place with finger pressure, or orthodontic interven-
one-third of the root, and no treatment is necessary tion may be required to move the displaced segment
D E
Figure 15-15 A, Crown-root fracture of a right central incisor necessitating orthodontic extrusion owing to palatal extension of fracture.
Note that the loose palatal segment (arrow) is still present. B, Adequate remaining tooth length allows use of the technique. C, One-visit root
canal therapy performed after removal of loose palatal fragement. D and E, Extrusion hook cemented in prepared post space.
F G
H I
Figure 15-15 (Continued) F, Horizontal wire attached to adjacent teeth at desired position by acid-etched composite. G, Activation elastic
placed over hook and wire. H, Two weeks later, the tooth has extruded the desired distance. I, It is now stabilized for 8 weeks by use of liga-
ture wire.
J K
L
Figure 15-15 (Continued) J, Note apical radiolucency (arrows) immediately following extrusion and
K, recalcification after 8 weeks of stabilization. L, Palatal tissue shows good adaptation to crown
(arrows). As a result of extrusion, gingival bevel could be placed on newly exposed tooth structure.
A B
Figure 15-16 A, Root fractures involve cementum, dentin, and
pulp and may occur in any part of the root: apical, middle, or coro- Figure 15-18 Root fracture (arrow) healed spontaneously. The
nal thirds. B, Fractures may also be comminuted (arrows). patient was unaware of the fracture.
B C D
A B
C D
Figure 15-19 Root fracture. A, Immediately after the accident. Note displacement of the coronal segment (arrows). B, The coro-
nal segment has been repositioned and the splint has been attached to stabilize the fractured tooth. C, Radiograph taken just
before removal of the splint. D, Control radiograph taken 1 year after removal of the splint. The tooth is comfortable and responds
to the electric pulp test within normal limits. There is no abnormal mobility or discoloration of the tooth. (Courtesy of Dr.
Donald Peters.)
A B C
D E F
Figures 15-21 A, Healing by interproximal bone. B, Root fracture (arrow) resulting in total separation of fragments. C, Midroot facture sta-
bilized for 3 months. D, Note that after removing the splint, the incisal edges are even, yet a space is apparent between the segments. E, Eight
months later, bone is now apparent between segments. F, The interproximal space has enlarged further 2 years after the accident. The tooth
is firm and functional. Note calcification of the pulp space. (Courtesy of Dr. Milton Siskin.)
A B
C D E
Figure 15-23 Root fracture treated by root canal therapy of both apical and coronal fragments. A, Note the fistulous tract. B, Tract traced
with a gutta-percha point to the root fracture (white arrow). Periodontal lesion associated with fracture is evident (dark arrows). C, Segments
aligned properly so that instrumentation is possible. D, Sealer extruded into the interproximal area (arrows). E, Follow-up at 11 months
shows resolution of the lesion with a small remaining area expected to heal.
support a new crown. A reasonable guide is to con- loss of response to the EPT. Endodontic treatment is
sider a crown-root ratio of 1:1 to have adequate not indicated unless other evidence, such as root
support. See Figures 15-14 and 15-15 for extrusion resorption or periradicular radiolucencies, indicates
technique. pulp necrosis. Usually, if the pulp space becomes oblit-
erated, no radiolucencies are seen apically or associated
Follow-up and Prognosis. It is a commonly held with the fracture lines. Endodontic treatment then
opinion that teeth with root fractures have a poor prog- becomes a decision based on other factors pertinent to
nosis, particularly if the fracture is in the middle or coro- each individual case.57
nal third. Whereas it may be true that the prognosis is Teeth requiring endodontic treatment after root
poor for longitudinal fractures, it appears unfounded for fractures also have a good prognosis with proper treat-
transverse fractures56 (see Figure 15-19). ment unless the fracture is so close to the alveolar ridge
A slight discoloration of the crown is a frequent that it communicates with the gingival crevice.57,58 In
observation in healed root-fractured teeth, usually seen the latter case, removing the coronal fragment and
as a yellowing effect with reduced transparency.63 It is extruding the root orthodontically may be the treat-
associated with pulp obliteration and occasionally a ment of choice.52
A B
C D
Figure 15-24 A, Radiograph shows a central incisor with an apical root fracture and a crown fracture repaired with composite resin 7 years
earlier. The pulp had not survived the original injury, and the patient had an apical abscess. Note the separated apical root segment.
B, Radiograph taken 4 months after initial treatment: root canal cleaning and calcium hydroxide medications. C, The tooth immediately after
root canal filling. Note that the apical lesion responded favorably to the initial endodontic therapy and the apical root fragment is not
involved. D, Twelve months after filling the root canal, the radiograph shows good repair; the apical root fragment can be left in place.
Long-term follow-up with radiographs and clinical gence of the succedaneous tooth. Excessive manipula-
tests is indicated in root fractures cases, as with all tion may damage the permanent tooth bud.53
other types of dental injury. It would appear that few
root-fractured teeth need to be extracted. With proper Luxation Injuries
treatment, even those with coronal-third involvement This category of dental injuries includes impact trauma
can be expected to survive, although some will require that ranges from minor crushing of the periodontal lig-
endodontic and possibly orthodontic intervention. ament and the neurovascular supply to the pulp to
Primary Teeth. Root fractures are infrequent in more major trauma such as forceful and sometimes
primary teeth. When they occur, however, the coronal total displacement of teeth (avulsion).
fragment should be extracted. If the removal of the api- Injury to a tooths supporting structure seldom
cal segment requires much manipulation, it may be left spares the pulp from trauma. Only in cases of minimal
in its socket. It will resorb during the growth and emer- trauma does the pulp have a good chance of recover-
ing. Otherwise, when a tooth is impacted by a blow, the negative response later have developed either pulp
force is very likely to damage the vasculature entering necrosis or calcification. However, without other indi-
the apical canal opening, with the result that the pulpal cations of pulp necrosis, endodontic intervention
blood supply is compromised64,65 (see chapter 4). should not be based solely on a negative response.
Besides pulpal injuries, impact trauma may also Treatment. Initial treatment can be as simple as
affect the tooths periodontal support. Loss of attach- doing nothing while the patient avoids use of the tooth.
ment, if not restored by subsequent repair, will result in In more serious luxations, treatment may range from
pocket formation and reduction in tooth support. The slight occlusal adjustment to repositioning (reduction)
goal in treatment of luxation injuries is to promote and splinting (stabilization) for 2 to 6 weeks. If symp-
recovery of both pulpal and periodontal health; realis- toms and other conditions (crown fracture with pulp
tically, except in young, immature teeth, pulpal recov- exposure) indicate irreversible pulp involvement,
ery is not as likely to occur as periodontal repair.66 endodontic treatment is indicated immediately after
Incidence. Tooth luxation (not including avul- injury. Follow-up evaluation will determine possible
sion) is a frequent injury, comprising the largest group later need for root canal therapy.6973
of injuries in the classification of dental trauma, rang-
ing from 30 to 44%.66 These figures are probably on the Concussion
low side since many instances of mild luxation, such as This is the mildest form of luxation injury, and it is
concussion, go unreported. In severe injuries, luxations characterized by sensitivity to percussion only. No dis-
may go unnoticed in the face of more obvious injuries. placement has taken place, and there is no mobility as
It is important, though, to record findings indicating a result of the injury. Concussion is probably present in
luxations, even mild ones, because of the high rate of most cases of crown, root, and crown-root fractures.66
subsequent pulp necrosis, osteitis or apical periodonti- Treatment for concussion is symptomatic: allow the
tis, and root resorption associated with such injuries. tooth to rest as much as possible to promote recovery
Following extrusion-luxation, Dumsha and Hovland of trauma to periodontal ligament and apical vessels.
reported pulp necrosis in 51 of 52 teeth after a period Monitor pulpal status by EPT and watch clinically for
that ranged from 4 weeks to 18 months.67 tooth color changes and radiographically for evidence
A frequently overlooked cause of luxation injuries, of resorption. The prognosis is good.66
including avulsions, occurs during intubation in the
operating room. Damaged teeth were the most fre- Subluxation
quent anesthesia-related insurance claim during the When a tooth, as a result of trauma, is sensitive to per-
time period 1976 to 1983.68 cussion and has increased mobility, it is classified as
Diagnosis. Luxated teeth that have been loosened or subluxated. Electric pulp test results may be either no
slightly displaced are sensitive to biting and chewing. In response or positive; if they are the former, damage to
concussion, this may be the only symptom, and it is the apical neurovascular bundle is more severe, and
noted by percussing the tooth. In more severe injuries, pulpal recovery becomes questionable, except in devel-
such as subluxation and extrusive luxation, signs and oping teeth.6973
symptoms in addition to percussion sensitivity may be Treatment initially may be none, except to recom-
present: sensitivity to pressure and palpation of the alve- mend minimal use, or it may be necessary to stabilize
olus, mobility, dislocation, and possibly bleeding from the tooth for a short period of time (2 to 3 weeks) to
the periodontal ligament. Radiographs do not always promote periodontal ligament recovery and reduction
reveal the extent of injuries to the supporting structures in mobility1 (Figure 15-25).
but are important nonetheless; it is also important to Subluxated teeth need to be evaluated long enough to
include additional radiographic angulations. Dis- be certain that the pulps have fully recovered. It may take
coloration of the crown may also be noted and, if present 2 or more years before one can make such a final deter-
shortly after the injury, is indicative of severe pulp dam- mination. Pulps that do not recover sensitivity to EPT
age. Lateral and intrusive luxations are usually firmly dis- should be assumed to be necrotic even if they are asymp-
placed and may not be sensitive to percussion.66 tomatic. Definitive treatment for subluxated teeth often
Electric pulp testing should be carried out and includes root canal therapy for fully developed teeth.71
recorded in cases of luxation, in spite of the fact that an
initial no response is common. The results of the EPT Extrusive Luxation
provide the basis for later evaluation. It is generally Displacement of a tooth axially in a coronal direction
found that teeth with an initial normal response but a results in a partial avulsion. The tooth is highly mobile
A B
Figure 15-25 Examples of two types of functional splints. A, Unfilled resin is bonded to small, etched labial areas. Avoid etching inter-
proximally. B, A thin (0.3 mm) orthodontic wire can be bonded to small, etched labial areas with resin.
and is likely to be continually traumatized by contact Such displacement is called lateral luxation, and it is
with opposing teeth, owing to the premature occlusal often very painful, particularly when the displacement
condition, all of it contributing to patient discomfort results in the tooth being moved into a position of pre-
and severe tooth mobility66 (Figure 15-26). mature occlusion. An example of such lateral luxation is
Immediate urgent care consists of repositioning the when a maxillary incisor is pushed palatally. The crown
tooth, usually more easily accomplished than in lateral makes occlusal contact long before centric occlusion.
luxation, and stabilizing it by a functional splint for 4 to The tooth is painful from the injury alone, and the addi-
8 weeks (see Figure 15-25). The relatively long stabi- tional constant trauma of premature contact results in
lization period is to allow realignment of the periodon- severe pain.
tal ligament fibers supporting the tooth. It is important Initial, urgent care for lateral luxation cases includes
during this period that gingivitis be prevented. repositioning the tooth and stabilization if the tooth is
Gingival inflammation will negate any attempt of the mobile after being repositioned. Repositioning a later-
tissue to repair itself. During recovery, progress can be ally luxated tooth may require pressure application at
monitored by periodontal probing. When reattach- the apical end of the root in the direction of the root
ment has occurred, probing depth should be similar to apexs original location or by partially extracting the
pretrauma depth.1,66 tooth with forceps prior to repositioning. The splint-
Definitive treatment for extrusive luxation is likely ing, if needed, should be nonrigid and may need to be
to include root canal therapy,71 except in young, devel- in place for 3 to 4 weeks, depending on how soon the
oping teeth in which the pulps are more prone to supporting tissues recover.1,66
recover.69 It is important to watch for signs of root Definitive treatment for laterally luxated teeth includes
resorption if endodontic therapy, for any reason, is not root canal therapy (Figure 15-27, D), except in develop-
included in the early treatment plan. Root canal thera- ing teeth, which may revascularize.69,70 The tooth dis-
py should be performed if the pulpal condition at any placement has probably severed the blood vessels supply-
time is judged to be either irreversible pulpitis or pulp ing the pulp, resulting in an infarct of the pulp owing to
necrosis. It should be done without delay once the deci- hypoxia. The end result is coagulation necrosis, which,
sion to do so has been made to reduce the chances of even if asymptomatic, requires root canal therapy. If a
inflammatory root resorption.1,67 decision to delay endodontic treatment is made, it is
imperative to monitor the tooth radiographically for pos-
Lateral Luxation sible external, inflammatory root resorption. The prog-
Traumatic injuries may result in displacement of a tooth nosis for lateral luxation is good if proper endodontic
labially, lingually, distally, or mesially (Figure 15-27). therapy is performed when indicated.66
A B
C
Figure 15-26 A, Tooth extrusion is similar to luxation in that the tooth is displaced, but the direction is axial. It may be accompanied by
fracture of the alveolus. B, Note outline of root socket at apex (arrow). C, Bleeding is frequently seen from the gingival sulcus (arrows).
A B
C D
Figure 15-27 A, Tooth luxation with loosening and displacement is often accompanied by fracture or comminution of the alveolar socket.
B, Luxation displacement of left central and lateral incisor and canine (arrows). C, After repositioning. D, The incisor required root canal
therapy about 3 months later. Canine retained its pulp vitality. (Courtesy of Dr. Raleigh Cummings.)
A B
Figure 15-28 A, Graphic illustration of a tooth intruded into the alveolar bone. B, Clinical photograph of intruded incisor. Note bleeding
from injured labial gingiva.
does in fact erupt into the normal position, no other (Figure 15-30). The exception to endodontic treatment
treatment is needed. Radiographic control will proba- is when spontaneous eruption takes place in young,
bly show some bizarre pulpal calcification, but, lacking developing teeth1,66 (see Figure 15-29).
other evidence of pulpal deterioration, root canal ther- Prognosis and Follow-up Evaluation. Comp-
apy is not likely to be indicated. lications following luxation injuries are frequent. Pulp
Fully developed teeth, however, and those in which necrosis occurs in over half of the cases of lateral luxa-
the roots are close to being developed should be reposi- tion, and even in subluxations, pulp death occurs in 12
tioned either surgically or orthodontically or by a com- to 20% of cases.66 Extension of pulp necrosis to the
bination of both.1 If allowed to remain in an intruded periradicular tissues may take some time. Often apical
position, the tooth is very likely to become ankylosed, periodontitis is not detected for several years post trau-
and later attempts at extrusion will probably be unsuc- ma, emphasizing the absolute need for long-term
cessful. The pulp should be prophylactically extirpated follow-up.71
as soon as feasible, followed by completion of the root Other complications are crown discoloration and
canal treatment after healing of the periodontal ligament reduction of the pulp lumen by calcification (Figure
A B
Figure 15-29 A, Intruded immature tooth (arrow). B, Six weeks later. Note re-eruption of the left central incisor, almost catching up with
its contralateral mate.
A B
Figure 15-30 Maxillary central incisors were intruded; the crowns fractured also. A, The intruded teeth were orthodontically extruded and
the pulps were extirpated, followed by placement of calcium hydroxide in the canals. B, Radiographs taken after extrusion was accomplished
and the root canals were filled. The entire procedure took place over a 2-year period. No evidence of ankylosis is present. (Courtesy of Dr.
Arthur LeClaire.)
A B
Figure 15-32 External inflammatory resorption. A, Accidentally
luxated tooth, radiograph taken 8 weeks after the incident. Note
resorption of both dental hard tissues as well as adjacent alveolar
bone. B, Immediately after root canal therapy. C, Control radiograph
taken 12 months later. Note repair of the alveolus and establishment
of a new periodontal ligament space. The root canal procedure
arrested the resorptive process. (Courtsey of Dr. Romulo de Leon.)
A B
Figure 15-33 A, Internal resorption with a history of trauma. B, Immediately following root canal therapy.
A B
Figure 15-36 Fracture prone tooth. A, Owing to pulp necrosis in a developing tooth, apexification was
begun with a good initial result; the apex was developing a hard tissue barrier. But the tooth is weak and
prone to fracture cervically (arrow). B, The tooth did fracture as a result of a minor injury to the teeth.
B C
Because little or no hard tissue barrier is present api- The most common observation of intruded primary
cal to primary teeth, traumatic intrusion of a primary teeth is a yellow crown discoloration, indicating pulpal
tooth affects the odontogenesis and the eruption of the calcification. No treatment is indicated for such teeth
permanent tooth. On the other hand, the damage is unless pulp necrosis and apical periodontitis occur81
usually minor, and the majority of intruded primary (see Figure 15-38).
teeth re-erupt within 6 months. Treatment is only
symptomatic, but follow-up evaluation is important. If Tooth Avulsion
evidence of apical inflammation becomes apparent, An avulsed tooth is completely displaced out of its
endodontic treatment or extraction is indicated to pro- socket; this trauma has also been referred to as an exar-
tect the permanent successor.8284 ticulation.85
A C
B D
Figure 15-38 Luxation injury to primary tooth. A, After injury to the right primary central incisor, the crown showed discoloration, but
the tooth was otherwise asymptomatic. B, The radiograph shows no displacement of the tooth. C, Six months later, the discoloration is no
longer present, and D, the radiograph shows that the pulp has undergone calcific metamorphosis as a response to the trauma. (Courtesy of
Dr. Mitsuhiro Tsukiboshi)
Description and Incidence. Teeth can be avulsed alveolar fractures. Such fractures of the tooth socket may
in many trauma situations. Sports and automobile reduce the prognosis but are not always a contraindica-
accidents are the most frequent causes. The incidence tion. Examine the tooth carefully for debris or contami-
of avulsion is reported to be less than 3% of all dental nation. Record the time of the avulsion. The length of
injuries.85 extra-alveolar time determines both treatment proce-
Tooth avulsion is a true dental emergency since dures and prognosis. If the tooth has been left dry for less
timely attention to replantation could save many than 1 hour or kept in milk for no more than 4 to 6 hours,
teeth.85 Unfortunately, avulsed teeth are usually lost at the protocol for treatment is described as immediate
the accident scene, and both accident victims and those replantation; more than 1 hour of dry time is delayed
attending them may neglect to consider the value of replantation.1,11,85
finding and saving the teeth. This may gradually Treatment: Immediate Replantation. Treatment
change as the public continues to become aware of the success for avulsed teeth can be directly related to the
possibilities that avulsed teeth can be saved. extra-alveolar time before replantation: the sooner an
Examination. The patient should be carefully exam- avulsed tooth is replanted, the better the prognosis.86
ined regardless of whether the tooth has been replanted With that in mind, dentists and their staff should be
before coming to the dental office. Radiographs and clin- prepared to advise parents and others who may call to
ical examination are necessary to help detect possible report a tooth avulsion (Table 15-2).
A B
the alveolar socket for foreign bodies and debris, taking teeth. It is most important that it not be in hyperoc-
care not to scrape the bony walls. The blood clot in the clusion. Such premature contact would delay or pre-
socket can be gently suctioned and the socket irrigated vent recovery.85
with saline. Check the avulsed tooth for debris on the Next, evaluate the need for stabilization. Splinting
root; if such debris cannot be rinsed off with saline or may not be necessary if the tooth fits firmly in its sock-
water, gently pick it off with cotton pliers. While et. If there is mobility, however, it should be stabilized
inspecting the tooth, it can be held by the crown with a with a functional splint (see Figure 15-25). Use either a
pair of extraction forceps. This permits examination of thin orthodontic wire (0.3 mm) attached with acid-
the tooth without touching the root surface. etched resin to the labial surfaces of the replanted and
After examining the alveolus and the tooth, begin adjacent teeth or use only an unfilled resin bonded to
replantation. Gently insert the tooth into the socket; small etched labial spots. In mixed dentition and cases
anesthesia will probably not be necessary. The insertion of missing, nonreplaceable adjacent teeth, other types
should be slow and gentle so that pressure is mini- of splints may be necessary.1,85,86
mized. When the tooth is nearly in place, have the The splint should be left in place only long enough
patient complete the process by biting on a piece of for the initial reattachment of periodontal ligament
gauze. Even small children will be able to follow the fibers; in most cases, that can be expected to take place
instruction to bite gently, and it allows them a measure in 1 to 2 weeks, after which the splint should be
of participation in the treatment. removed 1,85,86 (Figure 15-42).
The following steps in the replantation treatment Further support of the replantation procedure con-
also apply to situations in which the tooth may have sists of initial antibiotic coverage, tetanus prevention,
been replanted before the patients arrival. Check it for and root canal therapy. The latter is ideally performed
alignment with respect to adjacent and opposing 10 to 14 days after replantation.
A B
Figure 15-42 A, Replanted tooth splinted for 7 days. A normal periodontal ligament (PDL) is evident in this 4-month specimen. B,
Replanted tooth splinted for 30 days. Replacement and inflammatory resorption covered the apical half of the tooth. b = bone; c = cemen-
tum; d = dentin. Reproduced with permission from Nasjleti CE, Castelli, WA, Caffesse RG. Oral. Surg 1982; 53:557.
Antibiotics should be administered from the time of (about 2 weeks), and in situations in which resorption
replantation; prescribe a dosage regimen similar to that has begun, use the calcium hydroxide until resorption
recommended for a mild to moderate dental infection. has ceased. The completion of the root canal treatment
Coverage for 5 to 7 days should suffice.85,91 must include a proper root canal filling and a protective
If the patient has not had a tetanus vaccination, coronal restoration.
referral to a hospital or physician is indicated. If the Treatment: Delayed Replantation. The treatment for
patient has had a vaccination, but more than 5 years teeth with more than 1 hour of extra-alveolar time includes
have passed since the vaccination or any subsequent efforts to slow the inevitable replacement resorption:
booster injections, a booster injection following the
replantation is necessary. 1. Examine the avulsed tooth for debris. In contrast to
The optimal time for root canal therapy in a replant- avulsed teeth with less than 1 hour extra-alveolar
ed avulsed tooth is about 10 to 14 days after replanta- time, those with more than 1 hour are not expected
tion.85,89,92 The only exception to the rule of root canal to retain the vitality of periodontal ligament cells
therapy for avulsed teeth is when the tooth is still devel- and fibers. Therefore, it is best to remove pieces of
oping and has a wide open apical foramen9395 (Figure soft tissue attached to the root surface. This needs to
15-43). Such teeth have the potential for pulp revascu- be accomplished without overtly scraping the root
larization. If the replanted tooth falls into this category, surface.1,11,85
monitor its progress carefully with frequent, periodic 2. Perform root canal therapy with the tooth in vitro.
radiographs. If the pulp does not revascularize, it will This can often be best accomplished by holding the
become necrotic and lead to the same postreplantation tooth by the crown and proceeding with the
sequelae that can be expected from any replanted tooth endodontic treatment through an apical approach.
that has not been treated endodontically: inflammato- Cut off 2 to 3 mm of the root apex to expose the root
ry resorption (Figure 15-44). canal, extirpate the content of the canal and pulp
Calcium hydroxide has been recommended as an chamber, and then fill with gutta-percha and sealer.
intracanal medication during root canal therapy.85,96,97 An advantage in doing root canal therapy this way,
Based on current evidence,89,92,9799 it appears reason- along with convenience, is that the crown of the
able to use calcium hydroxide for canal disinfection tooth can be left intact.
A B
Figure 15-43 An avulsed left central incisor in a 6-year-old boy was replanted immediately. A, When re-evaluated after 8 weeks, there was
still response to electric pulp testing. B, One year after trauma, the tooth was in the normal position and had no discoloration but did not
respond to electric pulp testing. The root has continued to develop and the pulp appears to be calcifying. Also note hourglass
erosion/resorption cervically (arrows). (Courtesy of Dr. Robert Bravin.)
B C
3. Soak the tooth in a 2.4% fluoride solution acidulat- Because replanted teeth with more than 1 hour of
ed at pH 5.5 for 20 minutes or more. The fluoride extra-alveolar time are expected to resorb and ankylose,
will slow the resorptive process.1,85 it is probably reasonable to expect only a limited length
4. Prepare the tooth socket by gently curetting the of service from such teeth.101 However, if the resorption
blood clot out of the alveolar socket and then irri- is relatively slow, several years of service may result, and
gate with saline.1,85 this is probably reason enough for performing this rela-
5. Rinse the tooth thoroughly in saline and then insert tively simple procedure. It must be noted, however, that
it into the socket and splint for 6 weeks.1,85 in young patients, such ankylosis can result in a lack of
6. An additional procedure that is showing promise alveolar ridge development, so when infraocclusion
in reducing resportion is to fill the tooth socket becomes apparent in a growing child, it may be advisable
with Emdogain (Biora, Inc, Chicago, Illinois) prior to remove the crown in a process termed decoronation
to replantation.100 to allow proper ridge development.102
Avulsed Teeth with Open Apices. The only excep- visible on radiographs and is usually repaired by new
tion to the rule that replanted teeth must be treated cementum. It may be transitory or progressive. The
endodontically is the situation in which a very imma- former leads to repair, the latter to further resorption
ture, developing tooth with a wide open apex has been (see below). Surface resorption is usually detectable
avulsed and replanted (see Figure 15-43). Such teeth only histologically and probably represents part of
have the potential for revascularization and therefore the process that takes place both during recovery and
should be monitored after replantation to look for as a prelude to more severe resorption.107
signs of revascularization (ie, continued root forma- Inflammatory resorption: radiographically seen as a
tion and absence of resorption and ankylosis).95,103,104 bowl-shaped resorptive area of the root and associat-
It has been recommended to soak the avulsed tooth in ed with adjacent bony radiolucencies. It involves both
a solution of doxycycline (1 mg/20 mL saline) prior to tooth structure and adjacent bone. Radiographically,
replantation.11,104 there is apparent tooth loss along with adjacent bony
Primary Teeth. Most authors advise against destruction. This type of resorption is typical in the
replantation of primary teeth unless ideal conditions apical area involving any tooth with a necrotic pulp;
exist to prevent trauma to the permanent succedaneous replanted teeth that have not had root canal treatment
tooth.105 often show these resorptive lesions laterally as well as
Prognosis and Follow-up Evaluation. Resorption apically. Root canal therapy can be expected to arrest
is the most frequent sequela to luxation injuries; three inflammatory resorption that involves replanted
different types of resorption have been identified: sur- teeth; the resorption can be prevented by judicious
face, inflammatory, and replacement (ankylotic) timing of the root canal therapy. Optimally, that is
resorption106108: about 10 to 14 days post replantation1,11,85,86,106 (see
Figure 15-44).
Surface resorption: small superficial cavities in Replacement resorption: resorption of the root sur-
cementum and outermost dentin. This type is not face and its substitution by bone, resulting in anky-
A B
Figure 15-45 A, Reattachment of a replanted tooth treated enzymatically with hydrochloric acid, hyaluronidase, and glutaraldehyde.
B, Control tooth, untreated and replanted, with extensive inflammatory and replacement resorption. Reproduced with permission from
Nevins AJ, La Porta RF, Borden BG, Lorenzo P. Oral Surg 1980; 50:277.
A B
Figure 15-47 A, Alveolar fracture (arrows) and displacement of right canine treated by repositioning the tooth. B, A few weeks later symp-
toms indicative of apical periodontitis developed, and root canal therapy was performed. (Courtesy of Dr. Eugene Kozel.)
Figure 15-48 Panoramic film of an 8-year-old patient after a bicycle accident. In addition to maxillary anterior crown fractures, the left
temporomandibular condyle also fractured.
4. Andreasen JO. 35 years of dental traumatology. Lecture to the 26. Worthington RB, et al. Incisal edge reattachment: the effect of
International Association of Dental Traumatology, preparation utilization and design. Quintessence Int
Melbourne, Australia, March 15, 1999. 1999;30:637.
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53. Andreasen FM, Andreasen JO. Root fractures. In: Andreasen 74. Jacobsen I. Clinical follow-up study of permanent incisors
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Traumatol 1989;5:11. 76. Andreasen JO. Controversies and challenges in the managem-
55. Bender IB, Freedland JB. Clinical considerations in diagnosis nent of luxated teeth. Lecture at the American Association
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Assoc 1983;107:595. 77. Bystrm A, Claesson R, Sundqvist G. The antibacterial effect of
56. Cvek M, Andreasen JO, Borum MK. Healing of 208 intraalve- camphorated paramonochlorphenol, camphorated phenol
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Traumatol 2001;7:53. canals. Endod Dent Traumatol 1985;1:170.
57. Jacobsen I, Zachrisson BU. Repair characteristics of root frac- 78. Shabahang S, Torabinejad M. Treatment of teeth with open
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58. Zachrisson BU, Jacobsen I. Long-term prognosis of 66 perma- 79. Katebzadeh J, et al. Strengthening immature teeth during and
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1975;83:345. 80. Borum MK, Andreasen JO. Sequelae of trauma to primary
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63. Andreasen FM, Andreasen JO. Resorption and mineralization mary incisors on root development of their permanent
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69. Andreasen FM, et al. Relationship between pulp dimensions Endod Dent Traumatol 1986;2:67.
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Traumatol 1995;11:124. JO, Andreasen FM, editors. Textbook and color atlas of
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101. Andersson L, Blomlf L, Lindskog S, et al. Tooth ankylosis. mandibular fractures. Endod Dent Traumatol 1990;6:177.
Clinical, radiographic, and histological assessments. Int J 114. Markowitz NR. Evaluations and treatment of mandibular and
Oral Surg 1984;13:423. midface fractures. Can Dent Assoc J 1996;24:53.
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Scand J Dent Res 1984;92:391. 116. Bakland LK, Christiansen EL, Strutz JM. Frequency of dental
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ic systemic prophylaxis. Endod Dent Traumatol 117. Boyne PJ. Osseous repair and mandibular growth after sub-
1990;6:157. scondylar fractures. J Oral Surg 1967;25:300.
Chapter 16
TOOTH DISCOLORATION
AND BLEACHING
Ilan Rotstein
Tooth discoloration usually occurs owing to patient- or discoloration is time dependent; intracoronal bleaching
dentist-related causes1,2 (Table 16-1). is usually quite effective in this type of discoloration.35
PATIENT-RELATED CAUSES Dentin Hypercalcification
Pulp Necrosis Excessive formation of irregular dentin in the pulp
Bacterial, mechanical, or chemical irritation to the pulp chamber and along canal walls may occur following
may result in tissue necrosis and release of disintegra- certain traumatic injuries. In such cases, a temporary
tion by-products that may penetrate tubules and dis- disruption of blood supply occurs, followed by
color the surrounding dentin. The degree of discol- destruction of odontoblasts. These are replaced by
oration is directly related to how long the pulp has been undifferentiated mesenchymal cells that rapidly form
necrotic. The longer the discoloration compounds are irregular dentin on the walls of the pulp lumen. As a
present in the pulp chamber, the greater the discol- result, the translucency of the crowns of such teeth
oration. Such discoloration can usually be bleached gradually decreases, giving rise to a yellowish or yellow-
intracoronally (Figures 16-1 and 16-2). brown discoloration.
Extracoronal bleaching may be attempted first.
Intrapulpal Hemorrhage However, sometimes root canal therapy is required fol-
Intrapulpal hemorrhage and lysis of erythrocytes are a lowed by intracoronal bleaching.
common result of traumatic injury to a tooth. Blood
Age
disintegration products, presumably iron sulfides, flow
into the tubules and discolor the surrounding dentin. If In elderly patients, color changes in the crown occur
the pulp becomes necrotic, the discoloration persists physiologically, a result of excessive dentin apposition,
and usually becomes more severe with time. If the pulp thinning of the enamel, and optical changes. Food and
recovers, the discoloration may be reversed, with the beverages also have a cumulative discoloration effect.
tooth regaining its original shade. The severity of such These become more pronounced in the elderly, owing
to the inevitable cracking, crazing, and incisal wear of
the enamel and underlying dentin. In addition, amal-
Table 16-1 Causes of Tooth Discoloration gam and other coronal restorations that degrade over
time cause further discoloration. When indicated,
Patient-Related Causes Dentist-Related causes
bleaching can be successfully done for many types of
Pulp necrosis Endodontically related discolorations in elderly patients.
Intrapulpal hemorrhage Pulp tissue remnants
Dentin hypercalcification Intracanal medicaments TOOTH FORMATION DEFECTS
Age Obturating materials Developmental Defects
Tooth formation defects Restoration related Discoloration may result from developmental defects
Developmental defects Amalgams during enamel and dentin formation, either hypocal-
Drug-related defects Pins and posts cific or hypoplastic. Enamel hypocalcification is a dis-
Composites tinct brownish or whitish area, commonly found on
A B
Figure 16-1 A, Post-traumatic discoloration of a maxillary left central incisor. B, A mixture of perborate and distilled water, placed in the
chamber 2 times over 3 weeks, achieved the lightening of the tooth to its natural color. Reproduced with permission from Docteur Anne
Claisse-Crinquette. Leclaireissement des dyschromies: une longue histoire. Paris, France, Endo Contact 1999;2:16.
the facial aspect of affected crowns. The enamel is well Several other systemic conditions may cause tooth
formed with an intact surface. discoloration. Erythroblastosis fetalis, for example, may
Enamel hypoplasia differs from hypocalcification in occur in the fetus or newborn because of Rh incom-
that the enamel is defective and porous. This condition patibility factors, with resulting massive systemic lysis
may be hereditary, as in amelogenesis imperfecta, or a of erythrocytes. Large amounts of hemosiderin pig-
result of environmental factors such as infections, ment are released, which subsequently penetrate and
tumors, or trauma. Presumably, during enamel forma- discolor the forming dentin. This condition may also
tion, the matrix is altered and does not mineralize present a variety of systemic complications.6 However,
properly. The defective enamel is porous and readily such discoloration is now uncommon and is not
discolored by materials in the oral cavity. In such cases, amenable to bleaching. High fever during tooth forma-
bleaching effect may not be permanent depending on tion may also result in chronologic hypoplasia, a tem-
the severity and extent of hypoplasia and the nature of porary disruption in enamel formation that gives rise
the discoloration. to banding-type surface discoloration. Porphyria, a
A B
Figure 16-2 Traumatic pulp necrosis and dentin discoloration of a maxillary central incisor. A, Before treatment. B, Esthetic results fol-
lowing one treatment of walking bleach with sodium perborate mixed with Superoxol. Reproduced with permission from Nutting EB, Poe
GS. Dent Clin North Am 1967;655.
metabolic disease, may also cause red or brownish dis- bleaching of the anterior teeth is observed, particularly
coloration of deciduous and permanent teeth. in individuals whose teeth are excessively exposed to
Thalassemia and sickle cell anemia may cause intrinsic sunlight owing to maxillary lip insufficiency.
blue, brown, or green discolorations. Amelogenesis Two approaches have been used to treat tetracycline
imperfecta may result in yellow or brown discol- discoloration: (1) bleaching the external enamel sur-
orations. Dentinogenesis imperfecta can cause brown- face911 (Figure 16-4) and (2) intracoronal bleaching fol-
ish violet, yellowish, or gray discoloration. These con- lowing intentional root canal therapy1214 (Figure 16-5).
ditions are usually not amenable to bleaching and Endemic Fluorosis. Ingestion of excessive
should be corrected by restorative means. amounts of fluoride during tooth formation may pro-
duce a defect in mineralized structures, particularly in
Drug-Related Defects the enamel matrix, causing hypoplasia. The severity
Administration or ingestion of certain drugs during and degree of subsequent staining generally depend on
tooth formation may cause severe discoloration both in the degree of hypoplasia and are directly related to the
enamel and dentin.7,8 amount of fluoride ingested during odontogenesis.15
Tetracycline. This antibiotic was used extensively The teeth are not discolored on eruption, but their sur-
during the 1950s and 1960s for prophylactic protection face is porous and will gradually absorb colored chem-
and for the treatment of chronic obstructive pul- icals present in the oral cavity.
monary disease, Mycoplasma, and rickettsial infections. Discoloration is usually bilateral, affecting multiple
It was sometimes prescribed for long periods of time, teeth in both arches. It presents as various degrees of
years in some cases, and therefore was a common cause intermittent white spotting, chalky or opaque areas, yel-
of tooth discoloration in children. Although, today, low or brown discoloration, and, in severe cases, surface
tetracycline is not usually administrated chronically, pitting of the enamel. Since the discoloration is in the
dentists still face the residue of damage to the appear- porous enamel, such teeth can be bleached externally.
ance of the teeth of the prior two generations.
Tooth shades can be yellow, yellow-brown, brown,
dark gray, or blue, depending on the type of tetracy-
cline, dosage, duration of intake, and patients age at
the time of administration. Discoloration is usually
bilateral, affecting multiple teeth in both arches.
Deposition of the tetracycline may be continuous or
laid down in stripes depending on whether the inges-
tion was continuous or interrupted (Figure 16-3).
The mechanism of tetracycline discoloration is not
fully understood. Tetracycline bound to calcium is
thought to be incorporated into the hydroxyapatite
crystal of both enamel and dentin. However, most of
the tetracycline is found in dentin.
Tetracycline discoloration has been classified into
three groups according to severity.9 First-degree discol-
oration is light yellow, light brown, or light gray and
occurs uniformly throughout the crown, without
banding. Second-degree discoloration is more intense
and also without banding. Third-degree discoloration
is very intense, and the clinical crown exhibits horizon-
tal color banding. This type of discoloration usually
predominates in the cervical regions.
Repeated exposure of tetracycline-discolored tooth
to ultraviolet radiation can lead to formation of a red-
dish-purple oxidation by-product that permanently
discolors the teeth. In children, the anterior teeth often Figure 16-3 Fluorescent photomicrograph of tetracycline-discol-
discolor first, whereas the less exposed posterior teeth ored tooth. Tetracycline deposition is seen as stripes caused by start
are discolored more slowly. In adults, natural photo- and stop ingestion. (Courtesy of Dr. David L. Myers.)
A B
Figure 16-4 Extracoronal bleaching of tetracycline-discolored maxillary incisors. A, Before bleaching. B, After three sessions of bleaching
with Hi Lite Dual Activated Bleach as compared to unbleached discolored area of mandibular incisors. (Courtesy of Drs. Fred and Scott
Hanosh.)
A B
Figure 16-5 Intentional pulp devitalization and root canal obtura-
tion followed by intracoronal bleaching of tetracycline-discolored
teeth. A, All anterior teeth badly discolored from tetracycline inges-
tion when the patient was 2 to 3 years old. B, Trial treatment tooth
(central incisor) successfully bleached. C, All six maxillary anterior
teeth subsequently bleached. Contrast with discolored mandibular
incisors is apparent. Reproduced with permission from Abou-Rass
M. Alpha Omegan. 1982;75:57.
vent retention of sealer at a later stage. Intracoronal Sometimes the dark appearance of the crown is
bleaching in these cases is usually successful. caused by the amalgam restoration that can be seen
Intracanal Medicaments. Several intracanal through the tooth structure. In such cases, replacing
medicaments are liable to cause internal staining of the the amalgam with an esthetic restoration usually cor-
dentin. Phenolics or iodoform-based medicaments rects the problem.
sealed in the root canal and chamber are in direct con- Pins and Posts. Metal pins and prefabricated posts
tact with dentin, sometimes for long periods, allowing are sometimes used to reinforce a composite restora-
penetration and oxidization. These compounds have a tion in the anterior dentition. Discoloration from inap-
tendency to discolor the dentin gradually. propriately placed pins and posts is caused by the metal
Obturating Materials. This is a frequent and seen through the composite or tooth structure. In such
severe cause of single tooth discoloration. Incomplete cases, coverage of the pins with a white cement or
removal of obturating materials and sealer remnants in removal of the metal and replacement of the compos-
the pulp chamber, mainly those containing metallic ite restoration is indicated.
components,16 often results in dark discoloration. This Composites. Microleakage around composite
is easily prevented by removing all materials to a level restorations causes staining. Open margins may allow
just below the gingival margin (Figure 16-6). chemicals to enter between the restoration and the
Intracoronal bleaching is the treatment of choice; tooth structure and discolor the underlying dentin. In
prognosis, however, in such cases depends on the type addition, composites may become discolored with
of sealer and duration of discoloration. time, affecting the shade of the crown. These condi-
tions are generally corrected by replacing the old com-
Restoration Related posite restoration with a new, well-sealed one.
Amalgams. Silver alloys have severe effects on
dentin owing to dark-colored metallic components BLEACHING MATERIALS
that can turn the dentin dark gray. When used to Many different bleaching agents are available today; the
restore lingual access preparations or a developmental ones most commonly used are hydrogen peroxide,
groove in anterior teeth, as well as in premolar teeth, sodium perborate, and carbamide peroxide. Hydrogen
amalgam may discolor the crown. Such discolorations peroxide and carbamide peroxide are mainly indicated
are difficult to bleach and tend to rediscolor with time. for extracoronal bleaching, whereas sodium perborate
is used for intracoronal bleaching.
Hydrogen Peroxide. Various concentrations of
this agent are available, but 30 to 35% stabilized aque-
ous solutions (Superoxol, Perhydrol Merck & Co.; West
Point, Pa.) are the most common. Silicone dioxide gel
forms containing 35% hydrogen peroxide are also
available, some of them activated by a composite cur-
ing light (Figure 16-7).
Hydrogen peroxide is caustic and burns tissues on
contact, releasing toxic free radicals, perhydroxyl
anions, or both. High-concentration solutions of
hydrogen peroxide must be handled with care as they
are thermodynamically unstable and may explode
unless refrigerated and kept in a dark container.
Sodium Perborate. This oxidizing agent is available
in a powdered form or as various commercial prepara-
tions. When fresh, it contains about 95% perborate, cor-
responding to 9.9% of the available oxygen. Sodium
perborate is stable when dry. In the presence of acid,
warm air, or water, however, it decomposes to form sodi-
Figure 16-6 Gutta-percha and dentin removal prior to bleaching.
Heavyily dotted area represents gutta-percha filling, which is
um metaborate, hydrogen peroxide, and nascent oxygen.
removed to a level just below the gingival level (open arrow). Three types of sodium perborate preparations are
Lightly dotted area represents removal of dentin to eliminate heavy available: monohydrate, trihydrate, and tetrahydrate.
stain concentration and pulp horn material (black arrow). They differ in oxygen content, which determines their
Table 16-3 Clinical Reports of External Root Resorption Associated with Hydrogen Peroxide Bleaching
Previous Trauma Heat Applied Barrier Used
No. of Age of
Authors Cases Patients Yes No Yes No Yes No
A B
Figure 16-9 Postbleaching external root resorption. A, Nine-year recall radiograph of a central incisor devitalized by trauma and treated
endodontically shortly thereafter. B, Radiograph taken 2 years following bleaching. Superoxol and heat were used first and followed by walk-
ing bleach with Superoxol and sodium perborate. (Courtesy of Drs. David Steiner and Gerald Harrington.)
the presence of bacteria.38,49 Previous traumatic injury Suggestions for Safer Bleaching of
and age may act as predisposing factors.34 Endodontically Treated Teeth
Chemical Burns. Thirty percent hydrogen perox- Isolate the tooth effectively. Intracoronal bleaching
ide is caustic and causes chemical burns and sloughing should always be carried out with rubber dam isola-
of the gingiva. When using such solutions, the soft tis- tion. Interproximal wedges and ligatures may also be
sues should always be protected with Vaseline or used for better protection.
Orabase. Protect the oral mucosa. Protective creams, such as
Damage to Restorations. Bleaching with hydrogen Orabase or Vaseline, must be applied to the surround-
peroxide may affect bonding of composite resins to ing oral mucosa to prevent chemical burns by caustic
dental hard tissues.50 Scanning electron microscopy oxidizers. Animal studies suggest that catalase applied
suggests a possible interaction between composite resin to oral tissues prior to hydrogen peroxide treatment
and residual peroxide, causing inhibition of polymer- totally prevents the associated tissue damage.54
ization and an increase in resin porosity.51 This pres- Verify adequate endodontic obturation. The quality
ents a clinical problem when immediate esthetic of root canal obturation should always be assessed
restoration of the bleached tooth is required. It is there- clinically and radiographically prior to bleaching.
fore recommended that residual hydrogen peroxide be Adequate obturation ensures a better overall prog-
totally eliminated prior to composite placement. nosis of the treated tooth. It also provides an addi-
It has been shown that immersion of peroxide- tional barrier against damage by oxidizers to the
treated dental tissues in water at 37C for 7 days pre- periodontal ligament and periapical tissues.
vents the reduction in bond strength.52 In another Use protective barriers. This is essential to prevent
study, the efficacy of catalase in removing residual leakage of bleaching agents that may infiltrate
hydrogen peroxide from the pulp chamber of human between the gutta-percha and root canal walls,
teeth, as compared to prolonged rinsing in water, was reaching the periodontal ligament via dentinal
assessed.53 Three minutes of catalase treatment effec- tubules, lateral canals, or the root apex. In none of
tively removed all of the residual hydrogen peroxide the clinical reports of post-bleaching root resorption
from the pulp chamber. was a protective barrier used.
Various materials can be used for this purpose. enamel, especially when combined with strong oxi-
Barrier thickness and its relationship to the cemen- dizers.30,31 Although no direct correlation has been
toenamel junction are most important.28,55 The found between heat applications alone and external
ideal barrier should protect the dentinal tubules and cervical root resorption, it should be limited during
conform to the external epithelial attachment bleaching procedures.
(Figure 16-10). Recall periodically. Bleached teeth should be fre-
Avoid acid etching. It has been suggested that acid quently examined both clinically and radiographi-
etching of dentin in the chamber to remove the cally. Root resorption may occasionally be detected
smear layer and open the tubules would allow better as early as 6 months after bleaching. Early detection
penetration of the oxidizer. This procedure has not improves the prognosis since corrective therapy may
proven beneficial.56 The use of caustic chemicals in still be applied.
the pulp chamber is undesirable as periodontal liga-
ment irritation may result. Post-Bleaching Tooth Restoration
Avoid strong oxidizers. Procedures and techniques Proper tooth restoration is essential for long-term
applying strong oxidizers should be avoided if they sucessful bleaching results. Coronal microleakage of
are not essential for bleaching. Solutions of 30 to lingual access restorations is a problem,57 and a leaky
35% hydrogen peroxide, either alone or in combina- restoration may lead to rediscoloration.
tion with other agents, should not be used routinely There is no ideal method for filling the chamber
for intracoronal bleaching. after tooth bleaching. The pulp chamber and access
Sodium perborate is mild and quite safe, and no cavity should be carefully restored with a light-cured
additional protection of the soft tissues is usually acid-etched composite resin, light in shade. The com-
required. Generally, however, oxidizing agents posite material should be placed at a depth that seals
should not be exposed to more of the pulp space and the cavity and provides some incisal support. Light cur-
dentin than absolutely necessary to obtain a satisfac- ing from the labial surface, rather than the lingual sur-
tory clinical result. face, is recommended since this results in shrinkage of
Avoid heat. Excessive heat may damage the cemen- the composite resin toward the axial walls, reducing the
tum and periodontal ligament as well as dentin and rate of microleakage.58
Placing white cement beneath the composite access
restoration is recommended. Filling the chamber com-
pletely with composite may cause loss of translucency
and difficulty in distinguishing between composite and
tooth structure during rebleaching.59
As previously stated, residual peroxides from bleach-
ing agents, mainly hydrogen peroxide and carbamide
peroxide, may affect the bonding strength of compos-
ites.25,50 Therefore, waiting for a few days after bleach-
ing prior to restoring the tooth with composite resin
has been recommended. Catalase treatment at the final
visit may enhance the removal of residual peroxides
from the access cavity; however, this requires further
clinical investigation.53
Packing calcium hydroxide paste in the pulp cham-
ber for a few weeks prior to placement of the final
restoration, to counteract acidity caused by bleaching
agents and to prevent root resorption, has also been
suggested; this procedure, however, is unnecessary with
walking bleach.18
Thermo/Photo Bleaching peroxide liquid on the labial surface of the teeth using
This technique basically involves application of 30 to a small cotton pellet or a piece of gauze. A bleaching
35% hydrogen peroxide and heat or a combination of gel containing hydrogen peroxide may be used
heat and light or ultraviolet rays to the enamel surface instead of the aqueous solution (see Figure 16-4).
(Table 16-4). Heat is applied either by electric heating 10. Apply heat with a heating device or a light source.
devices or heat lamps. The technique involves the fol- The temperature should be at a level the patient can
lowing steps: comfortably tolerate, usually between 125F and
140F (52C to 60C). Rewet the enamel surface
1. Familiarize the patient with the probable causes of with hydrogen peroxide as necessary. If the teeth
discoloration, procedure to be followed, expected become too sensitive, discontinue the bleaching
outcome, and possibility of future rediscoloration. procedure immediately. Do not exceed 30 minutes
2. Make radiographs to detect the presence of caries, of treatment even if the result is not satisfactory.
defective restorations, and proximity to pulp horns. 11. Remove the heat source and allow the teeth to cool
Well-sealed small restorations and minimal down for at least 5 minutes. Then wash with warm
amounts of exposed incisal dentin are not usually a water for 1 minute and remove the rubber dam. Do
contraindication for bleaching. not rinse with cold water since the sudden change
3. Evaluate tooth color with a shade guide and take in temperature may damage the pulp or can be
clinical photographs before and throughout the painful to the patient.
procedure. 12. Dry the teeth and gently polish them with a com-
4. Apply a protective cream to the surrounding gingi- posite resin polishing cup. Treat all of the etched
val tissues and isolate the teeth with a rubber dam and bleached surfaces with a neutral sodium fluo-
and waxed dental floss ligatures. If a heat lamp is ride gel for 3 to 5 minutes.
used, avoid placing rubber dam metal clamps as 13. Inform the patient that cold sensitivity is common,
they are subjected to heating and may be painful to especially during the first 24 hours after treatment.
the patient. Also, instruct the patient to use a fluoride rinse
5. Do not inject a local anesthetic. daily for 2 weeks.
6. Position protective sunglasses over the patients and 14. Re-evaluate the patient approximately 2 weeks later
the operators eyes. on the effectiveness of bleaching. Take clinical pho-
7. Clean the enamel surface with pumice and water. Avoid tographs with the same shade guide used in the pre-
prophylaxis pastes containing glycerine or fluoride. operative photographs for comparison purposes. If
8. As an optional procedure, acid etch the darkest or necessary, repeat the bleaching procedure.
most severely stained areas with buffered phosphoric
acid for 10 seconds and rinse with water for 60 sec- Complications and Adverse Effects. Postoperative
onds. A gel form of acid provides optimum control. Pain. A number of short- and long-term symptoms
Enamel etching for extracoronal bleaching is contro- may occur following extracoronal bleaching of vital
versial and should not be carried out routinely. teeth. A common immediate postoperative problem is
9. Place a small amount of 30 to 35% hydrogen perox- pulpalgia characterized by intermittent shooting pain.
ide solution into a dappen dish. Apply the hydrogen It may occur during or after the bleaching session and
usually persists for between 24 and 48 hours. The
intensity of the pulpalgia is related to duration and the
temperature of the bleaching procedure. Shorter
Table 16-4 Indications and Contraindications for bleaching periods are therefore recommended. If long-
Thermo/Photo Extracoronal Bleaching term sensitivity to cold develops, topical fluoride treat-
Indications Contraindications ments and desensitizing toothpastes should be used to
alleviate these symptoms.
Light enamel discolorations Severe dark discolorations
Pulpal Damage. Extracoronal bleaching with
Mild tetracycline Severe enamel loss
hydrogen peroxide and heat has been associated with
discolorations Proximity of pulp horns
some pulpal damage. Although investigators have not
Endemic fluorosis Hypersensitive teeth
found significant irreversible effects on the pulp,10,60,61
discolorations Presence of caries
these procedures must be approached and carried out
Age-related discolorations Large/poor coronal
with caution62 and not in the presence of caries, areas
restorations
of exposed dentin, or in close proximity to pulp horns.
enamel etching, and leaky restorations. If complica- is the products marketed to the public over the count-
tions occur, stop treatment and re-evaluate the feasi- er, often without professional control. Their use should
bility of continuation at a later date. Note that fre- be discouraged.
quently the incisal edges are bleached more readily Complications and Adverse Effects. Systemic
than the remainder of the crown (Table 16-6). Effects. Controlled mouthguard bleaching proce-
dures are considered relatively safe.19 However, some
The long-term esthetic results of this method are concern has been raised over bleaching gels inadver-
unknown. However, it appears that rediscoloration is tently swallowed by the patient. Accidental ingestion of
not more frequent than with the other techniques. To large amounts of these gels may be toxic and cause irri-
date, no conclusive experimental or clinical studies on tation to the gastric and respiratory mucosa.67
the safety of long-term use of these bleaching agents Bleaching gels containing carbopol, which retards the
are available. Therefore, caution should be exercised in rate of oxygen release from peroxide, are usually more
their prescription and application.66 Of major concern toxic. Therefore, it is advisable to pay specific attention
to any adverse systemic effects and to discontinue treat-
ment immediately if they occur.
Dental Hard Tissue Damage. In vitro studies indi-
Table 16-6 Indications and Contraindications for cate morphologic and chemical changes in enamel,
Mouthguard Vital Bleaching dentin, and cementum associated with some agents
Indications Contraindications used for mouthguard bleaching.2023 Long-term in
vivo studies are still required to determine the clinical
Superficial enamel Severe enamel loss
significance of these changes.
discolorations Hypersensitive teeth
Tooth Sensitivity. Transient tooth sensitivity to
Mild yellow discolorations Presence of caries
cold may occur during or after mouthguard bleaching.
Brown fluorosis Defective coronal
In most cases, it is mild and ceases on termination of
discolorations restorations
treatment. Treatment for sensitivity consists of removal
Age-related discolorations Allergy to bleaching gels
of the mouthguard for 2 to 3 days, reduction of wear-
Bruxism
ing time, and re-adjustment of the guard.
24. Crim GA. Post-operative bleaching: effect on microleakage. 49. Heling I, Parson A, Rotstein I. Effect of bleaching agents on
Am J Dent 1992;5:109. dentin permeability to Streptococcus faecalis. JOE
25. Titley KC, Torneck CD, Ruse ND. The effect of carbamide-per- 1995;21:540.
oxide gel on the shear bond strength of a microfil resin to 50. Titley KC, Torneck CD, Ruse ND, Krmec D. Adhesion of a
bovine enamel. J Dent Res 1992;71:20. resin composite to bleached and unbleached human enam-
26. Spasser HF. A simple bleaching technique using sodium el. JOE 1993;19:112.
perborate. N Y State Dent J 1961;27:332. 51. Titley KC, et al. Scanning electron microscopy observations on
27. Nutting EB, Poe GS. A new combination for bleaching teeth. J the penetration and structure of resin tags in bleached and
South Calif Dent Assoc 1963;31:289. unbleached bovine enamel. JOE 1991;17:71.
28. Steiner DR, West JD. A method to determine the location and 52. Torneck CD, Titley KC, Smith DC, Adibfar A. Effect of water
shape of an intracoronal bleach barrier. JOE 1994;20:304. leaching on the adhesion of composite resin to bleached
29. Holmstrup G, Palm AM, Lambjerg-Hansen H. Bleaching of and unbleached bovine enamel. JOE 1991;17:156.
discoloured root-filled teeth. Endod Dent Traumatol 53. Rotstein I. Role of catalase in the elimination of residual
1988;4:197. hydrogen peroxide following tooth bleaching. JOE
30. Madison S, Walton RE. Cervical root resorption following 1993;19:567.
bleaching of endodontically treated teeth. JOE 1990; 54. Rotstein I, Wesselink PR, Bab I. Catalase protection against
16:570. hydrogen peroxide-induced injury in rat oral mucosa. Oral
31. Rotstein I, et al. Histological characterization of bleaching- Surg 1993;75:744.
induced external root resorption in dogs. JOE 1991;17:436. 55. Rotstein I, Zyskind D, Lewinstein I, Bamberger N. Effect of dif-
32. Lin LC, Pitts DL, Burgess LW. An investigation into the feasi- ferent protective base materials on hydrogen peroxide leak-
bility of photobleaching tetracycline-stained teeth. JOE age during intracoronal bleaching in vitro. JOE
1988;14:293. 1992;18:114.
33. Anitua E, Zabalegui B, Gil J, Gascon F. Internal bleaching of 56. Casey LJ, Schindler WG, Murata SM, Burgess JO. The use of
severe tetracycline discolorations: four-year clinical evalua- dentinal etching with endodontic bleaching procedures.
tion. Quintessence Int 1990;21:783. JOE 1989;15:535.
34. Harrington GW, Natkin E. External resorption associated with 57. Wilcox LR, Diaz-Arnold A. Coronal microleakage of perma-
bleaching of pulpless teeth. JOE 1979;5:344. nent lingual access restorations in endodontically treated
35. Lado EA, Stanley HR, Weisman MI. Cervical resorption in anterior teeth. JOE 1989;15:584.
bleached teeth. Oral Surg 1983;55:78. 58. Lemon R. Bleaching and restoring endodontcally treated teeth.
36. Montgomery S. External cervical resorption after bleaching a Curr Opin Dent 1991;1:754.
pulpless tooth. Oral Surg 1984;57:203. 59. Freccia WF, Peters DD, Lorton L. An evaluation of various per-
37. Shearer GJ. External resorption associated with bleaching of a manent restorative materials effect on the shade of
non-vital tooth. Aust Endod Newslett 1984;10:16. bleached teeth. JOE 1982;8:265.
38. Cvek M, Lindvall AM. External root resorption following 60. Cohen SC. Human pulpal response to bleaching procedures
bleaching of pulpless teeth with oxygen peroxide. Endod on vital teeth. JOE 1979;5:134.
Dent Traumatol 1985;1:56. 61. Robertson WD, Melfi RC. Pulpal response to vital bleaching
39. Latcham NL. Postbleaching cervical resorption. JOE procedures. JOE 1980;6:645.
1986;12:262. 62. Nathanson D. Vital tooth bleaching: sensitivity and pulpal
40. Goon WWY, Cohen S, Borer RF. External cervical root resorp- considerations. J Am Dent Assoc 1998;128 Suppl:41S.
tion following bleaching. JOE 1986;12:414. 63. Rotstein I, Lehr T, Gedalia I. Effect of bleaching agents on inor-
41. Friedman S, et al. Incidence of external root resorption and ganic components of human dentin and cementum. JOE
esthetic results in 58 bleached pulpless teeth. Endod Dent 1992;18:290.
Traumatol 1988;4:23. 64. Lewinstein I, Hirschfeld Z, Stabholz A, Rotstein I. Effect of
42. Gimlin DR, Schindler WG. The management of postbleaching hydrogen peroxide and sodium perborate on the micro-
cervical resorption. JOE 1990;16:292. hardness of human enamel and dentin. JOE 1994;20:61.
43. Al-Nazhan S. External root resorption after bleaching: a case 65. Garber DA. Dentist-monitored bleaching: a discussion of
report. Oral Surg 1991;72:607. combination and laser bleaching. J Am Dent Assoc
44. Heithersay GS, Dahlstrom SW, Marin PD. Incidence of inva- 1997;128 Suppl:26S.
sive cervical resorption in bleached root-filled teeth. Aust 66. Li Y. Toxicological considerations of tooth bleaching using
Dent J 1994;39:82. peroxide-containing agents. J Am Dent Assoc 1997;128
45. Heller D, Skriber J, Lin LM. Effect of intracoronal bleaching on Suppl:31S.
external cervical root resorption. JOE 1992;18:145. 67. Redmond AF, Cherry DV, Bowers DE Jr. Acute illness and
46. Rotstein I, Torek Y, Misgav R. Effect of cementum defects on recovery in adult female rats following ingestion of a tooth
radicular penetration of 30% H2O2 during intracoronal whitener containing 6% hydrogen peroxide. Am J Dent
bleaching. JOE 1991;17:230. 1997;10:268.
47. Koulaouzidou E, et al. Role of cementoenamel junction on the 68. Rotstein I, Mor C, Arwaz JR. Changes in surface levels of mer-
radicular penetration of 30% hydrogen peroxide during cury, silver, tin and copper of dental amalgam treated with
intracoronal bleaching in vitro. Endod Dent Traumatol carbamide peroxide and hydrogen peroxide. Oral Surg
1996;12:146. 1997;83:506.
48. Rotstein I, Torek Y, Lewinstein I. Effect of bleaching time and 69. Haywood VB, Heymann HO. Response of normal and tetracy-
temperature on the radicular penetration of hydrogen per- cline-stained teeth with pulp-size variation to nightguard
oxide. Endod Dent Traumatol 1991;7:196. vital bleaching. J Esthet Dent 1994;6:109.
Chapter 17
PEDIATRIC ENDODONTICS
Clifton O. Dummett Jr and Hugh M. Kopel
Treatment of pulpally inflamed primary and perma- It is for this reason that maximum attempts must be
nent teeth in children presents a unique challenge to made to preserve primary teeth in a healthy state until
the dental clinician. Pulp diagnosis in the child is normal exfoliation occurs. A major contention in con-
imprecise as clinical symptoms do not correlate well temporary research involving vital pulp treatment is
with histologic pulpal status. Age and behavior can the definition of healthy pulp status ascribed to many
compromise the reliability of pain as an indicator of of the treatment outcomes. This issue will be addressed
the extent of pulp inflammation. Furthermore, treat- in more detail later in this chapter.
ment goals are developmentally oriented and may be Vital pulp therapy is based on the premise that pulp
relatively short term by comparison to the long-term tissue has the capacity to heal. In addition to the bio-
restorative permanence of adult endodontics. logic basis for the healing capacity of the pulp, differ-
Because of this latter fact, a major focus in pediatric ences between primary and permanent teeth exist from
pulp therapy is vital pulp treatment, that capitalizes a morphologic and histologic standpoint. These differ-
on the healing potential of the noninflamed remain- ences must be addressed by the clinician to successful-
ing portions of the pulp. With instances of irre- ly treat pulpally inflamed teeth in children.
versibly inflamed and necrotic radicular pulps, con-
ventional concepts of nonvital pulp treatment are PULP MORPHOLOGY
indicated. However, they must be modified to accom-
modate physiologic root resorption in primary teeth Anatomic Differences Between Primary and
and continued root development in young perma- Permanent Teeth
nent teeth. Anatomic differences between the pulp chambers and
Lewis and Law succinctly stated the ultimate objec- root canals of primary teeth and those of young perma-
tive of pediatric pulp therapy: The successful treat- nent teeth have been described2 (Figure 17-1): (1) Pulp
ment of the pulpally involved tooth is to retain that chamber anatomy in primary teeth approximates the
tooth in a healthy condition so it may fulfill its role as a surface shape of the crown more closely than in perma-
useful component of the primary and young perma- nent teeth. (2) The pulps of primary teeth are propor-
nent dentition.1 Premature loss of primary teeth from tionately larger and the pulp horns extend closer to the
dental caries and infection may result in the following outer surfaces of the cusps than in permanent teeth. (3)
sequelae: The pulp-protecting dentin thickness between the pulp
chamber and the dentinoenamel junction is less than in
Loss of arch length permanent teeth. These three factors increase the poten-
Insufficient space for erupting permanent teeth tial for pulp exposure from mechanical preparation,
Ectopic eruption and impaction of premolars dental caries, and trauma. (4) An increased number of
Mesial tipping of molar teeth adjacent to primary accessory canals and foramina, as well as porosity in pul-
molar loss pal floors of primary teeth, has been noted in compari-
Extrusion of opposing permanent teeth son with permanent teeth.3 This is thought to account
Shift of the midline with a possibility of crossbite for the consistent pulp necrosis response of furcation
occlusion radiolucency in primary teeth versus periapical radiolu-
Development of certain abnormal tongue positions cency in permanent teeth.46
ing teeth for vital pulp therapy.3 Eidelman et al.21 and dentin, after deep excavation, with no exposure of the
Prophet and Miller22 have emphasized that no single pulp. In 1961, Damele described the purpose of indi-
diagnostic means can be relied on for determining a rect pulp capping as the use of reconstructed dentin
diagnosis of pulp conditions. Rayner and Southam have to prevent pulp exposure.25 The treatment objective is
stated that the inflammation response to the effects of to avoid pulp exposure and the necessity of more inva-
dentin caries in the deciduous pulp is more rapid than in sive measures of pulp therapy by stimulating the pulp
the permanent pulp.23 Yet Taylor concluded that in spite to generate reparative dentin beneath the carious
of being inflamed and infected by the carious process, lesion. This results in the arrest of caries progression
primary molars are still capable of marked defense reac- and preservation of the vitality of the nonexposed
tions similar to those observed in permanent teeth.24 pulp.26 This technique can be used as a one-sitting pro-
The goal in managing the deep carious lesion is cedure or the more classic two-sitting procedure. The
preservation of pulp vitality before arbitrarily institut- latter involves re-entry after a 6 to 8-week interval to
ing endodontic therapy. A suggested outline for deter- remove any remaining carious dentin and place the
mining the pulpal status of cariously involved teeth in final restoration3,27 (Figure 17-4).
children involves the following: DiMaggio found, in a histologic evaluation of teeth
selected for indirect treatment, that 75% would have
1. Visual and tactile examination of carious dentin and been pulp exposures if all of the caries had initially
associated periodontium been removed. Using clinical criteria, this same study
2. Radiographic examination of showed a failure rate of only 1% for indirect pulp caps
a. periradicular and furcation areas compared with 25% failure for direct caps.28 A histo-
b. pulp canals logic examination, however, raised these failure rates to
c. periodontal space 12% and 33%, respectively. Trowbridge and Berger
d. developing succedaneous teeth stated that complete removal of softened dentin, with
3. History of spontaneous unprovoked pain ensuing pulp exposure, may contribute nothing of
4. Pain from percussion diagnostic value in estimating the extent of existing
5. Pain from mastication pulp disease.29 In fact, other studies have shown that
6. Degree of mobility the true picture of pulp disease cannot be assessed on
7. Palpation of surrounding soft tissues the basis of such diagnostic criteria as history of pain,
8. Size, appearance, and amount of hemorrhage associ- response to temperature change, percussion, and elec-
ated with pulp exposures tric pulp testing.30,31
Historical Review all softened dentin was removed. These results were
The concept of indirect pulp capping was first further supported by Shovelton, who found that
described by Pierre Fauchard as reported by John although the deepest demineralized layers of dentin
Tomes in the mid-18th century, who recommended were generally free from infection, the possibility of a
that all caries should not be removed in deep, sensitive few dentinal tubules containing organisms did exist,
cavities for fear of exposing the nerve and making the especially in primary teeth.41 This finding was sup-
cure worse than the disease.32 John Tomes, in his mid- ported by Seltzer and Bender.42 Thus, complete clini-
19th century textbook, stated, It is better that a layer cal removal of carious dentin does not necessarily
of discolored dentin should be allowed to remain for ensure that all infected tubules have been eradicated.
the protection of the pulp rather than run the risk of Conversely, the presence of softened dentin does not
sacrificing the tooth.32 Although neither of these den- necessarily indicate infection.
tal pioneers referred to any specific medication for the A number of investigators have provided evidence
softened dentin, they recognized the healing capacity that the pulp can readily cope with minute contami-
of the pulp. nation. Reeves and Stanley43 and Shovelton44 showed
In 1891, W. D. Miller discussed various antisep- that when the carious lesion proximity to the pulp was
tics that should be used for sterilizing dentin.34 In greater than 0.8 mm (including reparative dentin
contrast to these early reports advocating conservative when present), no significant disturbance occurred
management of deep lesions, G. V. Black felt that in the within the pulp of permanent teeth. Rayner and
interest of scientific dental practice, no decayed or soft- Southam, in studying carious primary teeth, found the
ened material should be left in a cavity preparation, mean depth of pulp inflammatory changes from bac-
whether or not the pulp was exposed.35 terial dentin penetration to be 0.6 mm in proximity to
the pulp, with some changes occurring within a
Rationale 1.8 mm pulp proximity.23 Massler considered that
Indirect pulp capping is based on the knowledge that pulp reactions under deep carious lesions result from
decalcification of the dentin precedes bacterial invasion bacterial toxins rather than the bacteria themselves.45
within the dentin.3638 This technique is predicated on Massler and Pawlak used the terms affected and
removing the outer layers of the carious dentin, that infected to describe pulp reaction to deep carious
contain the majority of the microorganisms, reducing attack.46 This histologic study showed that the affect-
the continued demineralization of the deeper dentin ed pulp, beneath a deep carious lesion with a thin
layers from bacterial toxins, and sealing the lesion to layer of dentin between the pulp and the bacterial
allow the pulp to generate reparative dentin. Fusayama front, was often inflamed and painful but contained
and colleagues demonstrated that in acute caries, no demonstrable bacteria. However, when significant
dentin discoloration occurred far in advance of the numbers of bacteria were found within the infected
microorganisms, and as much as 2 mm of softened or pulp, a microscopic exposure in the carious dentin was
discolored dentin was not infected.38 In a later study, seen. Canby and Bernier concluded that the deeper
Fusayama found that carious dentin actually consists of layers of carious dentin tend to impede the bacterial
two distinct layers having different ultramicroscopic invasion of the pulp because of the acid nature of the
and chemical structures.39 The outer carious layer is affected dentin.47
irreversibly denatured, infected, and incapable of being The results of these studies indicate the presence of
remineralized and should be removed. The inner cari- three dentinal layers in a carious lesion: (1) a necrotic,
ous layer is reversibly denatured, not infected, and soft, brown dentin outer layer, teeming with bacteria
capable of being remineralized and should be pre- and not painful to remove; (2) a firmer, discolored
served. The two layers can be differentiated clinically by dentin layer with fewer bacteria but painful to remove,
a solution of basic fuchsin.39 suggesting the presence of viable odontoblastic exten-
Whitehead and colleagues compared deep excava- sions from the pulp; and (3) a hard, discolored dentin
tions in primary and permanent teeth.40 After all soft- deep layer with a minimal amount of bacterial invasion
ened dentin had been removed from the cavity floor, that is painful to instrumentation.
they found that 51.5% of the permanent teeth were
free from all signs of organisms, and a further 34% Response to Treatment
had only 1 to 20 infected dentinal tubules in any one Sayegh found three distinct types of new dentin in
section.40 Primary teeth, however, showed a much response to indirect pulp capping: (1) cellular fibrillar
higher percentage of bacteria in the cavity floor after dentin at 2 months post-treatment, (2) presence of
globular dentin during the first 3 months, and (3) 2. Clinical examination
tubular dentin in a more uniformly mineralized pat- a. Excessive tooth mobility
tern.17 In this study of 30 primary and permanent b. Parulis in the gingiva approximating the roots of
teeth, Sayegh concluded that new dentin forms fastest the tooth
in teeth with the thinnest dentin remaining after cavity c. Tooth discoloration
preparation. He also found that the longer treatment d. Nonresponsiveness to pulp testing techniques
times enhanced dentin formation.17 3. Radiographic examination
Diagnosis of the type of caries influences the treat- a. Large carious lesion with apparent pulp exposure
ment planning for indirect pulp capping. In the active b. Interrupted or broken lamina dura
lesion, most of the caries-related organisms are found in c. Widened periodontal ligament space
the outer layers of decay, whereas the deeper decalcified d. Radiolucency at the root apices or furcation areas
layers are fairly free of bacteria. In the arrested lesion, the
surface layers are not always contaminated, especially If the indications are appropriate for indirect pulp
where the surface is hard and leathery. The deepest lay- capping, such treatment may be performed as a two-
ers are quite sclerotic and free of microorganisms.48 appointment or a one-appointment procedure.
Deep carious dentin is even more resistant to decompo-
sition by acids and proteolysis than is normal dentin. Two-Appointment Technique (First Sitting).
This was especially true in arrested caries.49,50 1. Administer local anesthesia and isolate with a
Procedures for Indirect Pulp Capping rubber dam.
2. Establish cavity outline with a high-speed hand-
Case selection based on clinical and radiographic assess- piece.
ment to substantiate the health of the pulp is critical for 3. Remove the majority of soft, necrotic, infected
success. Only those teeth free from irreversible signs dentin with a large round bur in a slow-speed hand-
and symptoms should be considered for indirect pulp piece without exposing the pulp.
capping. The following measures should be employed 4. Remove peripheral carious dentin with sharp spoon
for those teeth appropriate for this technique. excavators. Irrigate the cavity and dry with cotton
Indications. The decision to undertake the indi- pellets.
rect pulp capping procedure should be based on the 5. Cover the remaining affected dentin with a hard-set-
following findings: ting calcium hydroxide dressing.
6. Fill or base the remainder of the cavity with a rein-
1. History forced ZOE cement (IRM Dentsply-Caulk; Milford.)
a. Mild discomfort from chemical and thermal or a glass-ionomer cement to achieve a good seal.
stimuli 7. Do not disturb this sealed cavity for 6 to 8 weeks. It
b. Absence of spontaneous pain may be necessary to use amalgam, composite resin,
2. Clinical examination or a stainless steel crown as a final restoration to
a. Large carious lesion maintain this seal.
b. Absence of lymphadenopathy
c. Normal appearance of adjacent gingiva Two-Appointment Technique (Second Sitting, 6 to
d. Normal color of tooth 8 Weeks Later). If the tooth has been asymptomatic,
3. Radiographic examination the surrounding soft tissues are free from swelling, and
a. Large carious lesion in close proximity to the pulp the temporary filling is intact, the second step can be
b. Normal lamina dura performed:
c. Normal periodontal ligament space
d. No interradicular or periapical radiolucency 1. Bitewing radiographs of the treated tooth should be
assessed for the presence of reparative dentin.
Contraindications. Findings that contraindicate 2. Again use local anesthesia and rubber dam isolation.
this procedure are listed below: 3. Carefully remove all temporary filling material,
especially the calcium hydroxide dressing over the
1. History deep portions of the cavity floor.
a. Sharp, penetrating pain that persists after 4. The remaining affected carious dentin should
withdrawing stimulus appear dehydrated and flaky and should be easily
b. Prolonged spontaneous pain, particularly at night removed. The area around the potential exposure
should appear whitish and may be soft; this is pre- remove the residual minimal carious dentin after cap-
dentin. Do not disturb! ping with calcium hydroxide may not be necessary if the
5. The cavity preparation should be irrigated and gen- final restoration maintains a seal and the tooth is asymp-
tly dried. tomatic.
6. Cover the entire floor with a hard-setting calcium After cavity preparation, if all carious dentin was
hydroxide dressing. removed except the portion that would expose the pulp,
7. A base should be placed with a reinforced ZOE or re-entry might be unnecessary.7 Conversely, if the clini-
glass ionomer cement, and the tooth should receive cian had to leave considerably more carious dentin
a final restoration. owing to patient symptoms, re-entry would be advised
to confirm reparative dentin and pulp exposure status. If
One-Appointment Technique. The value of a pulp exposure occurs during re-entry, a more invasive
re-entry and re-excavation has been questioned by vital pulp therapy technique such as direct pulp capping
some clinicians when viewed in light of numerous or pulpotomy would be indicated. Tooth selection for
studies reporting success rates of indirect pulp capping one-appointment indirect pulp capping must be based
with calcium hydroxide ranging from 73 to 98% (Table on clinical judgment and experience with many cases in
17-1). On this basis, the need to uncover the residual addition to the previously mentioned criteria.
dentin to remove dehydrated dentin and view the scle- Evaluation of Therapy. A histologic evaluation of
rotic changes has been questioned. The second entry pulp reactions to indirect pulp capping has been report-
subjects the pulp to potential risk of exposure owing to ed in a varying number of samples. Law and Lewis
overzealous re-excavation.7 reported irritational dentin formation, an active odonto-
Leung et al.51 and Fairbourn and colleagues52 have blastic layer, an intact zone of Weil, and a slightly hyper-
been able to show a significant decrease of bacteria in active pulp with the presence of some inflammatory
deep carious lesions after being covered with calcium cells.53 Held-Wydler demonstrated irritational dentin in
hydroxide (Dycal, Dentsply-Caulk; Milford.) or a modi- 40 of 41 young molars in which the carious dentin was
fied ZOE (IRM) for periods ranging from 1 to 15 covered with ZOE cement.54 The pulp tissue was either
months. These investigators suggested that re-entry to completely normal or mildly inflamed over a period of
Table 17-1 Studies on Indirect Pulp Capping in Primary and Young Permanent Teeth
Study Agent Cases Observation Period % of Success
34 to 630 days. In the histologic sections, four layers becomes remineralized. In contrast to ZOE, residual
could be demonstrated (Figure 17-5): (1) carious decal- dentin will increase in mineral content when in contact
cified dentin, (2) rhythmic layers of irregular reparative with calcium hydroxide.63,64
dentin, (3) regular tubular dentin, and (4) normal pulp Sawusch evaluated calcium hydroxide liners for
with a slight increase in fibrous elements. indirect pulp capping in primary and young perma-
Clinical studies have shown no significant differ- nent teeth. After periods ranging from 13 to 21 months,
ences in the ultimate success of this technique regard- he concluded that Dycal was a highly effective agent.65
less of whether calcium hydroxide or ZOE cement is Nirschl and Avery reported greater than 90% success
used over residual carious dentin.5557 However, rates for both Dycal and LIFE (SybronEndo/Kerr
Torstenson et al. demonstrated slight to moderate Corp.; Orange, Calif.) calcium hydroxide preparations
inflammation when ZOE was used in deep unlined when used as bases in both primary and permanent
cavities that were less than 0.5 mm to the pulp itself.58 teeth for indirect pulp-capping therapy.66
Nordstrom and colleagues reported that carious Coll et al., in an evaluation of several modes of pulp
dentin, wiped with a 10% solution of stannous fluoride therapy in primary incisors, stated that the success rates
for 5 minutes and covered with ZOE, can be remineral- of indirect pulp cappings in primary incisors did not
ized.59 It was further stated that no particular differ- differ from comparable molar rates.67 They showed a
ence was found in failure rates of teeth treated with cal- 92.3% success rate for treated incisors after a mean fol-
cium hydroxide and those treated with stannous fluo- low-up time of 42 months.
ride. As so many others have also concluded, the results The medicament choice for indirect pulp capping can
for primary and young permanent teeth do not differ be based on the clinical history of the carious tooth in
significantly (see Table 17-1). question. Some investigators recommend ZOE because
King and associates,60 as well as Aponte et al.61 and of its sealing and obtundant properties, which reduce
Parikh et al.,62 determined that the residual layer of pulp symptoms. Others recommend calcium hydroxide
carious dentin, left in the indirect pulp-capping tech- because of its ability to stimulate a more rapid formation
nique, can be sterilized with either ZOE cement or cal- of reparative dentin. Stanley believes that it makes no
cium hydroxide. However, it cannot be presumed that difference which is used because neither is in direct con-
all of the remaining infected or affected dentin tact with pulp tissue, and increased dentin thickness was
observed to occur beneath deep lesions treated with both
agents.57 However, in case of an undetected microscopic
pulp exposure during caries excavation, calcium hydrox-
ide will better stimulate a dentinal bridge.57,68 Primosch
et al. noted that the majority of US pediatric dentistry
undergraduate programs used calcium hydroxide as the
principal indirect pulp capping medicament in their
teaching protocols.69
Lado and Stanley demonstrated that light-cured cal-
cium hydroxide compounds were equally effective in
inhibiting growth of organisms commonly found at
the base of cavity preparations.70
A minimum indirect pulp post-treatment time peri-
od of 6 to 8 weeks should be allowed to produce ade-
quate remineralization of the cavity floor.7,17,71 This
desirable outcome is essentially dependent on the
maintenance of a patent seal against microleakage by
the temporary and final restorations. In this regard, the
Figure 17-5 Photomicrograph of four layers of healing under newer resin-reinforced glass ionomer cements and
indirect pulp capping of a permanent molar of a 1412-year-old dentin bonding agents should be considered.
child. Zinc oxideeugenol cement capping after excavation of the
necrotic dentin layer only. No pain 480 days later when extracted. 1 DIRECT PULP CAPPING
= carious decalcified dentin; 2 = rhythmic layers of irregular irrita-
tional dentin; 3 = regular tubular dentin; 4 = normal pulp with Direct pulp capping involves the placement of a bio-
slight increase in fibrous elements. Reproduced with permission compatible agent on healthy pulp tissue that has been
from Held-Wydler E.54 inadvertently exposed from caries excavation or trau-
Case Selection
Success with direct pulp capping is dependent on the
coronal and radicular pulp being healthy and free from
bacterial invasion.73,74 The clinician must rely on the
physical appearance of the exposed pulp tissue, radi-
ographic assessment, and diagnostic tests to determine
pulpal status.
Indications. Tooth selection for direct pulp cap-
ping involves the same vital pulp therapy considerations
mentioned previously, to rule out signs of irreversible
pulp inflammation and degeneration. The classic indi-
cation for direct pulp capping has been for pinpoint
mechanical exposures that are surrounded with sound
Figure 17-6 Direct pulp-capping technique. A, Capping material
covers pulp exposure and the floor of the cavity. B, Protective base
dentin.3,7,2124 The exposed pulp tissue should be bright
of zinc oxideeugenol cement. C, Amalgam restoration. red in color and have a slight hemorrhage that is easily
controlled with dry cotton pellets applied with minimal
pressure. Frigoletto noted that small exposures and a
good blood supply have the best healing potential.75
matic injury72 (Figure 17-6). The treatment objective is Although imprecise, the term pinpoint conveys the
to seal the pulp against bacterial leakage, encourage the concept of smallness to the exposed tissue, which
pulp to wall off the exposure site by initiating a dentin should have the lowest possibility of bacterial access. An
bridge, and maintain the vitality of the underlying pulp empirical guideline has been to limit the technique to
tissue regions (Figure 17-7). exposure diameters of less than 1 mm. Stanley has
A B
C D
Figure 17-7 Effect of calcium hydroxide and time on the healing of the capped pulp. A, Twenty-four hours after application of calcium
hydroxide. B, After 2 or 3 weeks. C, After 4 or 5 weeks. D, After 8 weeks. Reproduced with permission from Vermeersch AG.107
determined, however, that the size of the exposure is less studies that pulp healing can take place irrespective of
significant than the quality of the capping technique in the presence of overt inflammation.77,78 Cotton
avoiding contamination and mechanical trauma to the observed that when there is minimal pulp inflamma-
exposure site and careful application of the medicament tion, a bridge may form against the capping material,
to hemostatically controlled pulp tissue.74 Equally but when inflammation is more severe, the bridge is apt
important is the quality of the temporary or permanent to form at a distance from the exposure.79
restoration to exclude microleakage. Dentin bridge formation has been considered to be
Contraindications. Contraindications to direct the sine qua non for success in response to direct pulp-
pulp-capping therapy include a history of (1) sponta- capping procedures.73,8082 Weiss and Bjorvatn have
neous and nocturnal toothaches, (2) excessive tooth demonstrated, however, that a healthy pulp can exist
mobility, (3) thickening of the periodontal ligament, beneath a direct pulp cap even in the absence of a
(4) radiographic evidence of furcal or periradicular dentinal bridge.83 Kakehashi et al., in a germ-free ani-
degeneration, (5) uncontrollable hemorrhage at the mal study, found pulp exposure healing with bridging
time of exposure, and (6) purulent or serous exudate even when left uncovered84 (Figure 17-8). Seltzer and
from the exposure. Bender42 and Langeland et al.85 have shown that a
dentin bridge is not as complete as it appears, which
Clinical Success can ultimately lead to untoward pulp reactions. Cox
The salient features of a clinically successful direct pulp- and Subay found that 89% of bridges formed in
capping treatment (with or without bridging) are (1) response to calcium hydroxide direct pulp caps demon-
maintenance of pulp vitality, (2) absence of sensitivity or strated tunnel defects, which allowed access of
pain, (3) minimal pulp inflammatory responses, and (4) microleakage products beneath the restoration into the
absence of radiographic signs of dystrophic changes. pulp. They found recurrent pulp inflammation
Permanent Teeth. Several investigators have pro- beneath 41% of all bridges formed in the sample.86
vided evidence that direct pulp capping cannot be suc- It is generally considered that pulps inadvertently
cessful in the presence of pulpal inflammation and exposed and asymptomatic in the preoperative period
identify this condition as a contraindication to direct are more apt to survive when capped. The prognosis is
pulp capping.2 Tronstad and Mjr capped inflamed far less favorable if an attempt is made to cap an
pulps in monkey teeth with calcium hydroxide or ZOE inflamed pulp infected from caries or trauma.87 Also,
and found no beneficial healing of the exposed pulp the wide-open apices and high vascularity of young
when calcium hydroxide was used.76 More recently, permanent teeth enhance the successful outcome of
however, other investigators have shown in animal direct capping techniques.
A B
Figure 17-8 Role of bacteria in dentin repair following pulp exposure. A, Germ-free specimen, obtained 14 days after surgery, with food
and debris in occlusal exposure. Nuclear detail of the surviving pulp tissue (arrow) can be observed beneath the bridge consisting of dentin
fragments united by a new matrix. B, Intentional exposure of a first molar in a control rat (with bacteria) 28 days postoperatively. Complete
pulp necrosis with apical abscess. A reproduced with permission from Kakehashi S et al.84 B reproduced with permission from Clark JW and
Stanley HR. Clinical dentistry. Hagerstown (MD): Harper & Row; 1976.
Primary Teeth. Kennedy and Kapala attributed and Cvek were able to show a 93.5% success rate of par-
the high cellular content of pulp tissue to be responsi- tial pulpotomy in permanent posterior teeth with deep
ble for direct pulp-capping failures in primary teeth.88 carious lesions with exposed pulps.100 Fuks et al. found
Undifferentiated mesenchymal cells may give rise to similar partial pulpotomy success rates above 90% in
odontoclastic cells in response to either the caries permanent incisors with fracture-exposed pulps.101
process or the pulp-capping material, resulting in Bacterial Contamination. Watts and Paterson102
internal resorption. and Cox103 have both emphasized the fact that bacter-
Because of the pulp cellular content, increased ial microleakage under various restorations causes pul-
inflammatory response, and increased incidence of pal damage in deep lesions, not the toxic properties of
internal resorption, some pediatric dentists feel that the the cavity liners and/or restorative materials. The suc-
direct capping procedure is contraindicated in primary cess of pulp-capping procedures is dependent on pre-
teeth.27,89,90 Starkey and others feel that a high degree vention of microleakage by an adequate seal. Cox et al.
of success with direct pulp capping in primary teeth have shown that pulp healing is more dependent on the
can be achieved in carefully selected cases using specif- capacity of the capping material to prevent bacterial
ic criteria and treatment methods.9194 microleakage rather than the specific properties of the
material itself.104
Treatment Considerations Medications and Materials. Many medicaments
Dbridement. Kalins and Frisbee have shown that and materials have been suggested to cover pulp expo-
necrotic and infected dentin chips are invariably sures and initiate tissue healing and/or hard structure
pushed into the exposed pulp during the last stages of repair. Calcium hydroxide, in one form or another, has
caries removal.95 This debris can impede healing in the been singled out by a myriad of authors as the medica-
area by causing further pulpal inflammation and ment of choice for pulp exposures.80,82,105,106
encapsulation of the dentin chips. Therefore, it is pru- Antibiotics, calcitonin, collagen, corticosteroids, cyano-
dent to remove peripheral masses of carious dentin acrylate, formocresol, and resorbable tricalcium phos-
before beginning the excavation where an exposure phate ceramic have also been investigated, with varying
may occur. When an exposure occurs, the area should degrees of success. These latter compounds, with the
be appropriately irrigated with nonirritating solutions exception of formocresol, have not had sufficient clinical
such as normal saline to keep the pulp moist.81 impact to be adopted as the material of choice in direct
Hemorrhage and Clotting. Hemorrhage at the pulp capping, especially in the pediatric age groups.
exposure site can be controlled with cotton pellet pres- Calcium Hydroxide. Calcium hydroxide produces
sure. A blood clot must not be allowed to form after the coagulation necrosis at the contact surface of the pulp.
cessation of hemorrhage from the exposure site as it The underlying tissue then differentiates into odonto-
will impede pulpal healing.96 The capping material blasts, which elaborate a matrix in about 4 weeks.107
must directly contact pulp tissue to exert a reparative This results in the formation of a reparative dentin
dentin bridge response. Hemolysis of erythrocytes bridge, caused by the irritating quality of the highly
results in an excess of hemosiderin and inflammatory alkaline calcium hydroxide, which has a pH of 11 to
cellular infiltrate, which prolongs pulpal healing.74 12.108 Stanley has identified that the dentin bridging
Exposure Enlargement. There have been recom- effects of calcium hydroxide occur only when the agent
mendations that the exposure site be enlarged by a is in direct contact with healthy pulp tissue.74 Tamburic
modification of the direct capping technique known as et al. summarized the mineralizing effects of calcium
pulp curettage or partial pulpotomy prior to the place- hydroxide, which include cellular adenosine triphos-
ment of the capping material.3,93,96,97 Enlarging this phate activation resulting from calcium and hydroxyl
opening into the pulp itself serves three purposes: (1) it ion enhancement of alkalinity in the mineralization
removes inflamed and/or infected tissue in the exposed process.109
area; (2) it facilitates removal of carious and noncari- Yoshiba et al. provided immunofluorescence evi-
ous debris, particularly dentin chips; and (3) it ensures dence of the possible contribution of calcium hydrox-
intimate contact of the capping medicament with ide to odontoblastic differentiation. They found
healthy pulp tissue below the exposure site. increased amounts of fibronectin, an extracellular gly-
Cvek98 and Zilberman et al.99 have described highly coprotein implicated in cell differentiation, among
favorable results with this partial pulpotomy technique migrating fibroblasts and newly formed odontoblasts
for pulp-exposed, traumatized, anterior teeth and cari- in areas of initial bridge calcification in response to cal-
ous molars. After a 24-month waiting period, Mejare cium hydroxide. They noted that although calcium
hydroxide was not unique in initiating reparative the paste forms.82,118,119 Antibacterial properties and
dentinogenesis, it demonstrated the most rapid tubular physical strength to support amalgam condensation
dentin formation in comparison to calcium phosphate have been shown for the hard-set calcium hydroxide
ceramics and tricalcium phosphate.110 cements.51,103,120
Calcium hydroxide has significant antibacterial After a clinical investigation of two formulas of a
action, which has been identified as an additional ben- hard, self-setting calcium hydroxide compound
efit in capping procedures.111,112 Estrela et al. summa- (Dycal), Sawusch found calcium hydroxide liners to be
rized the antibacterial properties of calcium hydroxide, effective agents for direct and indirect pulp capping in
which include hydrolyzing bacterial cell wall lipo- both primary and young permanent teeth.65 He also
polysaccharides, neutralizing bacterial endotoxins, and found that failures in this study tended to be associat-
reducing anaerobic organisms through carbon dioxide ed with failed restorations and microleakage. Fuks et
absorption.113 al. observed an 81.5% success in young permanent
There is some controversy as to the source of calci- fractured teeth with pinpoint exposures when calcium
um ions necessary for dentinal bridge repair at the hydroxide was the capping material of choice.121
exposure site. Sciaky and Pisanti114 and Attalla and With the advent of visible light-curing restorative
Noujaim115 demonstrated that calcium ions from the resins, it was inevitable that, in the interest of efficien-
capping material were not involved in the bridge for- cy and improving the hardness of a cavity lining mate-
mation. Stark and his colleagues, however, believe that rial, light-cured calcium hydroxide pulp-capping prod-
calcium ions from the capping medicament do enter ucts were introduced. Stanley and Pameijer122 and
into bridge formation.116 Holland et al. provided addi- Seale and Stanley,123 in histologic studies, found that a
tional evidence to support this concept.117 calcium hydroxide product (Prisma VLC Dycal, L. D.
Seltzer and Bender identified the osteogenic potential Caulk Co.), cured by visible light, maintained all of the
of calcium hydroxide.42 It is capable of inducing calcif- characteristics of healing and bridge formation equiva-
ic metamorphosis, resulting in obliteration of the pulp lent to the original self-curing Dycal. Lado, in an in
chamber and root canals. This fact has raised concern vitro study comparing the bacterial inhibition of these
among clinicians.42 Lim and Kirk, in an extensive review new light-cured products to the self-setting calcium
of direct pulp capping literature, found little support for hydroxide cements, also found no differences.112
pulp obliteration and internal resorption being a major Howerton and Cox reported the same results as Stanley
complication of pulp capping.81 Although internal and Pameijer122 and Seale and Stanley123 using
resorption has been documented following calcium light-cured calcium hydroxide in monkeys.124
hydroxide pulpotomies in primary teeth, it does not
appear to be a problem in permanent teeth. Alternative Agents to Calcium Hydroxide
Jeppersen, in a long-term study using a creamy mix Suggested for Direct Pulp Capping in Primary
of calcium hydroxide placed on exposed pulps of pri- and Permanent Teeth
mary teeth, reported a 97.6% clinical success and 88.4% Zinc OxideEugenol Cement. Glass and Zander
histologic success.93 Although calcium hydroxide pastes found that ZOE, in direct contact with the pulp tissue,
have been shown to be effective in promoting dentin produced chronic inflammation, a lack of calcific bar-
bridges, their higher pH, water solubility, and lack of rier, and an end result of necrosis.80
physical barrier strength led manufacturers to introduce Hembree and Andrews, in a literature review of ZOE
modified calcium hydroxide cements that set quickly used as a direct pulp-capping material, could find no
and hard for lining cavities and pulp capping. positive recommendations.125 Watts also found mild to
Various studies have shown successful results of up moderate inflammation and no calcific bridges in the
to 80% with calcium hydroxide pulp capping of specimens under his study,126 and this was confirmed
involved primary teeth with or without coronal by Holland et al.127 Weiss and Bjorvatn, on the other
inflammation.65,94,96,118 These investigations support hand, noted negligible necrosis of the pulp in direct
the use of hard-set calcium hydroxide cements in place contact with ZOE but stated that any calcific bridging
of calcium hydroxide pastes without causing patholog- of an exposure site was probably a layer of dentinal
ic sequelae, such as internal resorption, associated with chips.83 They also found no apparent difference in the
pulp-capping failure. For example, the so-called pulp reactions of primary and permanent teeth.
necrobiotic and inflammatory zones are minimal, In spite of the reported lack of success with ZOE
and dentin bridges seem to form directly under these cement, Sveen reported 87% success with the capping
commercial compounds instead of at a distance from of primary teeth with ZOE in ideal situations of pulp
exposure.128 He offered no histologic evidence, but reduced antigenicity in pulp-exposed teeth of young
Tronstad and Mjr, comparing ZOE with calcium dogs.141 Although the material was found to be rela-
hydroxide, found ZOE more beneficial for inflamed, tively less irritating than calcium hydroxide, and with
exposed pulps and felt that the production of a calcific minimal dentin bridging in 8 weeks, it was concluded
bridge is not necessary if the pulp is free of inflamma- that collagen was not as effective in promoting a dentin
tion following treatment.76 bridge as was calcium hydroxide. Fuks et al. did find
Corticosteroids and Antibiotics. Corticosteroids dentin bridges after 2 months in 73% of pulpotomized
and/or antibiotics were suggested for direct pulp cap- teeth that had been capped with an enriched collagen
ping in the pretreatment phase and also to be mixed in solution.142 They felt that a different mechanism exists
with calcium hydroxide with the thought of reducing for the production of a truer dentin when a collagen
or preventing pulp inflammation. These agents includ- solution is used rather than with calcium hydroxide
ed neomycin and hydrocortisone,129 Cleocin,130 corti- because no coagulation necrosis was seen.
sone,131 Ledermix (calcium hydroxide plus pred- Formocresol. Because of the clinical success of
nisolone),132 penicillin,133 and Keflin (cephalothin formocresol when used in primary pulp therapy such
sodium).134 Although many of these combinations as pulpotomies and pulpectomies, several investigators
reduced pain for the most part, they were found only to have been intrigued by the possibility of its use as a
preserve chronic inflammation and/or reduce repara- medicament in direct pulp-capping therapy. Arnold
tive dentin. Also, Watts and Paterson cautioned that applied full-strength formocresol for 2 minutes over
anti-inflammatory compounds should not be used in enlarged pulp exposures in primary teeth and found a
patients at risk from bacteremia.135 Gardner et al. 97% clinical success after 6 months.97 Ibrahim et al.
found, however, that vancomycin, in combination with reported the absence of inflammation along with
calcium hydroxide, was somewhat more effective than dentin bridging in 15 experimental teeth when expo-
calcium hydroxide used alone and stimulated a more sures were medicated with formocresol for 5 minutes
regular reparative dentin bridge.136 and capped with a mixture of formocresol and ZOE
Polycarboxylate Cements. These cements have cement.143 More recently, Garcia-Godoy obtained a
also been suggested as a direct capping material. The 96% clinical and radiographic success rate in human
material was shown to lack an antibacterial effect and exposed primary molars when capped with a paste of
did not stimulate calcific bridging in the pulps of mon- one-fifth diluted formocresol mixed with a ZOE paste
key primary and permanent teeth.134 Negm et al. and covered with a reinforced ZOE cement.144
placed calcium hydroxide and zinc oxide into a 42% Hybridizing Bonding Agents. Recent evidence has
aqueous polyacrylic acid and used this combination for shown that elimination of bacterial microleakage is the
direct pulp exposure in patients from 10 to 45 years of most significant factor affecting restorative material bio-
age. This mixture showed faster dentin bridging over compatibility.145,146 A major shortcoming of calcium
the exposures in 88 to 91% of the patients when com- hydroxide preparations is their lack of adhesion to hard
pared to Dycal as the control.137 tissues and resultant inability to provide an adequate seal
Inert Materials. Inert materials such as isobutyl against microleakage.9,147 Furthermore, calcium hydrox-
cyanoacrylate138 and tricalcium phosphate ceramic139 ide materials have been found to dissolve under restora-
have also been investigated as direct pulp-capping tions where microleakage has occurred, resulting in bacte-
materials. Although pulpal responses in the form of rial access to the pulp.148 Currently, hybridizing dentinal
reduced inflammation and unpredictable dentin bridg- bonding agents (such as AmalgamBond or C & B
ing were found, to date, none of these materials have MetaBond, Parkell Products, Farmingdale, N.Y.) represent
been promoted to the dental profession as a viable the state of the art in mechanical adhesion to dentin with
technique. At Istanbul University, dentists capped 44 resultant microleakage control beneath restora-
pulps, half with tricalcium phosphate hydroxyapatite tions.9,149,150 Miyakoshi and et al. have shown the effec-
and half with Dycal (calcium hydroxide). At 60 days, tiveness of 4-META-MMA-TBB adhesives in obtaining an
none of the hydroxyapatite-capped pulps exhibited effective biologic seal.151 Cox et al. demonstrated that
hard tissue bridging but instead had mild inflamma- pulps sealed with 4-META showed reparative dentin
tion. Nearly all of the Dycal-capped pulps, however, deposition without subjacent pulp pathosis.152,153
were dentin bridged, with little or no inflammation.140 A number of investigators have proposed that sealing
Collagen Fibers. Because collagen fibers are vital pulp exposures with hybridizing dentin bonding
known to influence mineralization, Dick and agents may provide a superior outcome to calcium
Carmichael placed modified wet collagen sponges with hydroxide direct pulp-capping techniques.9,154 Because
of their superior adhesion to peripheral hard tissues, an studied teeth. This occurred in spite of the final com-
effective seal against microleakage can be expected. These posite resin restorations being resealed at 6-month
proposals have been made in spite of concerns with the intervals from the time of initial placement.161
effects of acid etchant and resin materials on pulp tissue. Gwinnett and Tay, using light microscopic and elec-
Snuggs et al. demonstrated that pulpal healing tron microscopic techniques, identified early and inter-
occurred, with bridge formation, in exposed primate mediate pulp responses to total-etch followed by a resin
teeth capped with acidic materials such as silicate bonding agent and composite resin restoration in
cement and zinc phosphate cement. This was contin- human teeth. Some specimens demonstrated signs of
gent on the fact of the biologic surface seal of the over- initial repair with dentin bridge formation along the
lying restoration remaining intact.147 Kashiwada and exposed site and reparative dentin adjacent to the
Takagi demonstrated 60 of 64 teeth to be vital and free exposed site. Other specimens demonstrated persist-
of any clinical and radiographic signs of pulp degener- ence of chronic inflammation with a foreign body
ation 12 months after pulp capping with a resin bond- response in the form of resin globules imbedded with-
ing agent and composite resin. The pulp tissue was not in the exposed pulp tissue that were surrounded by
exposed to acid conditioner during the technique. pulpal macrophages. This was also accompanied by a
Selected third molars receiving this treatment were his- mononuclear inflammatory infiltrate and an absence
tologically studied and demonstrated dentin bridge of calcific bridge formation.162
formation below the area of exposure.155 Although using dentin bonding agents as a replace-
Heitman and Unterbrink studied a glutaraldehyde- ment for calcium hydroxide in the direct pulp-capping
containing dentin bonding agent, in direct pulp-cap- technique has been advocated,163 more long-term evi-
ping exposed pulps, in eight permanent teeth. All dence and histologic evaluation are needed. Until such
exposed pulps were protected with calcium hydroxide evidence is available, the clinician would be prudent to
during application of the acid conditioner. After rins- employ a combination of calcium hydroxide as a
ing away the calcium hydroxide dressing and condi- medicament for the exposed pulp followed by a
tioner, the bonding agent was applied directly to the hybridizing resin bonding agent for a successful micro-
exposed pulp tissue and surrounding dentin. All teeth biologic seal.164,165 This concept is further substantiated
were vital after a 6-month postoperative period.156 by Katoh et al., who reported improved direct pulp-cap-
These results have been further substantiated by Cox ping results with dentin bonding agents when they were
and White and Bazzuchi et al.153,157 Kanca reported a used in conjunction with calcium hydroxide.166,167
4-year clinical and radiographic success with dentin Cell-Inductive Agents. A number of cell-inductive
bonding agent application following etching material agents have been proposed as potential direct pulp-cap-
applied directly to a fracture-induced exposed pulp ping alternatives to calcium hydroxide. These contempo-
and dentin in rebonding a tooth fragment.158 rary substances mimic the reciprocal inductive activities
Conversely, other investigators provide conflicting seen in embryologic development and tissue healing that
evidence that does not support using dentin bonding are receiving so much attention at this time.
agents in pulp-capping techniques. Stanley has stated Mineral trioxide aggregate (MTA) (Dentsply,
that acid conditioning agents can harm the pulp when Tulsa; Tulsa, Okla.) cement was developed at Loma
placed in direct contact with exposed tissues.159 In a Linda by Torabinejad for the purposes of root-end
primate tooth sample with pulp exposures treated with filling and furcation perforation repair.168 The mate-
total-etch followed by application of a dentin bonding rial consists of tricalcium silicate, tricalcium alumi-
agent, Pameijer and Stanley found that 45% became nate, tricalcium oxide, and silicate oxide. It is a
nonvital and 25% exhibited bridge formation after 75 hydrophilic material that has a 3-hour setting time in
days. In the no etch calcium hydroxide pulp-capping the presence of moisture. Major MTA advantages
sample, 7% became nonvital and 82% exhibited bridge include excellent sealing ability, good compressive
formation after the same time period.160 After 1 year, strength (70 MPa) comparable to IRM, and good bio-
Araujo et al. experienced a clinical and radiographic compatibility. Pitt Ford et al. documented superior
success rate of 81% in primary tooth exposures etched bridge formation and preservation of pulp vitality
and capped with resin adhesives. Histologic assessment with MTA when compared with calcium hydroxide in
of extracted sample teeth in advent of their exfoliation a direct pulp-capping technique.169 They also report-
demonstrated inflammatory infiltrate, microabscess ed normal cytokine activity in bone and cementum
formation, and no dentin bridging. Furthermore, bac- regeneration in response to MTA, which is indicative
terial penetration occurred in 50% of the histologically of its cell-inductive potential.169
Calcium phosphate cement has been developed for extraction and replacement with a space maintainer.172
repairing cranial defects following brain neurosurgery. Pulpotomy candidates should demonstrate clinical and
The components of this material include tetracalcium radiographic signs of radicular pulp vitality, absence of
phosphate and dicalcium phosphate, which react in an pathologic change, restorability, and at least two-thirds
aqueous environment to form hydroxyapatite, the min- remaining root length. Pulpotomized teeth should
eral component of hard tissues. Chaung et al. histolog- receive stainless steel crowns as final restorations to
ically compared calcium phosphate cement with calci- avoid potential coronal fracture at the cervical region.
um hydroxide as a direct pulp-capping agent. Although Pulpotomy is also recommended for young permanent
both materials produced similar results with respect to teeth with incompletely formed apices and cariously
pulp biocompatibility and hard tissue barrier forma- exposed pulps that give evidence of extensive coronal
tion, calcium phosphate cement was suggested as a tissue inflammation.
viable alternative because of (1) its more neutral pH Contraindications. According to Mejare, con-
resulting in less localized tissue destruction, (2) its traindications for pulpotomy in primary teeth exist
superior compressive strength, and (3) its transforma- when (1) root resorption exceeds more than one-third
tion into hydroxyapatite over time.170 of the root length; (2) the tooth crown is nonrestorable;
Yoshimine et al. demonstrated the potential benefits of (3) highly viscous, sluggish, or absent hemorrhage is
direct pulp capping with tetracalcium phosphatebased observed at the radicular canal orifices; as well as (4)
cement. As with calcium phosphate cement, this materi- marked tenderness to percussion; (5) mobility with
al has the ability to be gradually converted into hydroxy- locally aggravated gingivitis associated with partial or
apatite over time. In contrast to calcium hydroxide, tetra- total radicular pulp necrosis exists; and (6) radiolucen-
calcium phosphate cement induced bridge formation cy exists in the furcal or periradicular areas.173
with no superficial tissue necrosis and significant absence
of pulp inflammation.171
Summary: Direct Pulp Capping. Adherence to
established criteria for case selection is important to
achieve success. Although somewhat controversial
based on the previously reviewed studies, direct pulp
capping has been found to be less successful in pri-
mary teeth than indirect pulp therapy or coronal
pulpotomy. However, direct pulp capping tends to be
more successful in young permanent teeth.
PULPOTOMY
Pulpotomy is the most widely used technique in vital
pulp therapy for primary and young permanent teeth
with carious pulp exposures. A pulpotomy is defined as
the surgical removal of the entire coronal pulp pre-
sumed to be partially or totally inflamed and quite pos-
sibly infected, leaving intact the vital radicular pulp
within the canals.2 A germicidal medicament is then
placed over the remaining vital radicular pulp stumps
at their point of communication with the floor of the
coronal pulp chamber. This procedure is done to pro-
mote healing and retention of the vital radicular pulp.
Dentin bridging may occur as a treatment outcome of
this procedure depending on the type of medicament
used (Figure 17-9). Additional variables thought to
influence treatment outcome include the medication
type, concentration, and time of tissue contact.
Indications. According to Dannenberg, pulpo-
tomies are indicated for cariously exposed primary Figure 17-9 Dentin bridge following calcium hydroxide pulpoto-
teeth when their retention is more advantageous than my with LIFE. (Courtesy of SybronEndo/Kerr Orange, Ca.)
Persistent toothaches and coronal pus should also be The formocresol pulpotomy technique currently
considered contraindications. used is a modification of the original method reported
Treatment Approaches for Primary Teeth. Ranly, in by Sweet in 1930.180 By 1955, Sweet claimed 97% clini-
reviewing the rationale and various medicaments that cal success in 16,651 cases.181 It should be noted, how-
have guided the historical development of the pulpoto- ever, that in this report, about one half of the primary
my procedure, provided three categories of treatment teeth exfoliated early.
approaches. Devitalization was the first approach to be Histology. In spite of regional popularity, the mul-
used with the intention of mummifying the radicular tiple-visit pulpotomy did not receive wide acceptance
pulp tissue.174 The term mummified has been ascribed because it was regarded as a nonvital or devitalization
to chemically treated pulp tissue that is inert, sterilized, method. In addition, histologic studies to support its
metabolically suppressed, and incapable of autolysis.174 use were also lacking. It became overshadowed by the
This approach involved the original two-sitting so-called vital pulpotomy for primary teeth using
formocresol pulpotomy, which resulted in complete calcium hydroxide, which at that time was supported
devitalization of the radicular pulp. Also included were by clinical and histologic evidence. Interest in
the 5-minute formocresol and 1:5 diluted formocresol formocresol was renewed, however, with a reported
techniques, which both result in partial devitalization increase in clinical failures and radiographic evidence
with persistent chronic inflammation.174,175 of internal resorption with calcium hydroxide, even in
The preservation approach involved medicaments the presence of dentinal bridging.188 At the same time,
and techniques that provide minimal insult to the ori- improved clinical and histologic success rates were
fice tissue and maintain the vitality and normal histo- reported with formocresol.182
logic appearance of the entire radicular pulp. In spite of histologic studies that showed formalin,
Pharmacotherapeutic agents included in this category creosol, and paraformaldehyde to be connective tissue
are corticosteroids, glutaraldehyde, and ferric sulfate. irritants, it was recognized early that formocresol is an
Nonpharmacotherapeutic techniques in this category efficient bactericide. It was also found to have the
include electrosurgical and laser pulpotomies.174 ability to prevent tissue autolysis by the complex
The regeneration approach includes pulpotomy chemical binding of formaldehyde with protein.
agents that have cell-inductive capacity to either However, this binding reaction may be reversible as
replace lost cells or induce existent cells to differentiate the protein molecule does not change in its basic
into hard tissueforming elements. Historically, calci- overall structure.175
um hydroxide was the first medicament to be used in a Massler and Mansukhani conducted a detailed his-
regenerative capacity because of its ability to stimu- tologic investigation of the effect of formocresol on the
late hard tissue barrier formation. The calcium hydrox- pulps of 43 human primary and permanent teeth in
ide pulpotomy is predicated on the healing of pulp tis- multiple treatment intervals.183 Fixation of the tissue
sue beneath the overlying dentin bridge. Recently, its directly under the medicament was apparent. After a 7-
regenerative capacity has been questioned owing to the to 14-day application, the pulps developed three dis-
fact that calcium hydroxide tissue response is more tinctive zones: (1) a broad eosinophilic zone of fixa-
reactive than inductive. Examples of true cell-inductive tion, (2) a broad pale-staining zone with poor cellular
agents include transforming growth factor- (TGF-) definition, and (3) a zone of inflammation diffusing
in the form of bone morphogenetic proteins,176,177 apically into normal pulp tissue. After 60 days, in a lim-
freeze-dried bone,178 and MTA.168,169 These materials ited number of samples, the remaining tissue was
are more representative of the regeneration category believed to be completely fixed, appearing as a strand of
and provide the direction for future research in vital eosinophilic fibrous tissue.183
pulp therapy.174 Emmerson et al. also described the action of
formocresol on human pulp tissue.184 They reported
Formocresol Pulpotomy
Formocresol was introduced in 1904 by Buckley, who
contended that equal parts of formalin and tricresol *The formocresol used in this technique may be obtained under the
would react chemically with the intermediate and end trade name Buckleys Formocresol (Roth, Chicago, IL). Composition:
35% cresol, 19% formalin in a vehicle of glycerine and water at a pH
products of pulp inflammation to form a new, colorless,
of approximately 5.1. To dilute formocresol to one-fifth strength,
and non-infective compound of a harmless nature.179 thoroughly mix three parts of glycerine with one part of distilled
Buckleys formula, formocresol, consists of tricresol, water. Add these four parts to one part of concentrated commercial
19% aqueous formaldehyde, glycerine, and water.* formocresol compound.
that the effect on the pulp varied with the length of cal one-third tissue, which was normal and free of
time formocresol was in contact with the tissue. A inflammatory reaction. Initially, Spamer observed an
5-minute application resulted in surface fixation of acute inflammatory reaction, succeeded by a chronic
normal tissue, whereas an application sealed in for 3 inflammatory response, proliferation of odonto-
days produced calcific degeneration. They concluded blasts, and an increase in collagen fibers. By 6
that formocresol pulpotomy in primary pulp therapy months, deposition of mature dentin and vital tissue
may be classified as either vital or nonvital, depending was seen throughout.188
on the duration of the formocresol application. Formocresol Pulpotomy Outcomes: Primary Teeth.
Formocresol versus Calcium Hydroxide. Doyle et Rolling and Thylstrup reported a clinical 3-year fol-
al. compared the formocresol pulpotomy technique low-up study of pulpotomized primary molars using
with the calcium hydroxide technique in primary formocresol.189 Their results showed a progressively
canines and found the formocresol technique to be decreasing survival rate of 91% at 3 months, 83% at 12
95% clinically successful at the end of 1 year.182 months, 78% at 24 months, and 70% at 36 months
Although fixation of pulp tissue and some loss of cellu- after treatment. These investigators concluded that
lar definition were seen histologically, healthy, vital tis- although their rate of success was less than previous
sue existed in the apical third. The calcium hydroxide studies had shown, the formocresol method must be
technique was considered to be 61% clinically success- considered an acceptable clinical procedure compared
ful, and dentin bridge formation was seen in 50% of with other methods. Possibly, bacterial microleakage
the cases examined. over the longer time span accounted for their decreas-
Spedding et al. also studied these two medicaments ing success rate.
in monkeys and produced essentially the same results Rolling and coworkers, in later studies, investigated
as Doyle and colleagues.185 Law and Lewis evaluated the morphologic and enzyme histochemical reactions
the clinical effectiveness of the formocresol technique of pulpotomies done with formocresol in human pri-
over a 4-year period and reported a 93 to 98% success mary molars for periods ranging from 3 to 24 months
rate. Their failure rate was greatest between the first and 3 to 5 years.190,191 In these studies, a wide range of
and second years.186 pulpal reactions occurred, from normal pulps to total
Formocresol versus Zinc OxideEugenol. Berger chronic inflammation. In most instances, however, the
compared the pulpotomy effects of using a pulp tissue in the apical region was vital with minimal
one-appointment formocresol medication with those inflammation, which was in agreement with many
of ZOE paste alone on the amputated pulps of carious- other studies. It was concluded from both studies that
ly exposed human primary molars.187 Periods of eval- the formocresol method should be regarded as only a
uation ranged from 3 to 38 weeks postoperatively. means to keep primary teeth with pulp exposures func-
Clinically and radiographically, 97% of the formocre- tioning for a relatively short period of time.
sol-treated teeth were judged successful, whereas only Magnusson investigated therapeutic (ie, formocre-
58% of the teeth treated with ZOE were considered sol) pulpotomies and stated that his histologic exami-
successful. Histologically, 82% of the formocresol nations revealed early capricious diffusion of the
group was judged successful, compared to total failure medicament through the pulp tissue, producing chron-
with ZOE.187 ic inflammation and no healing in the apical areas along
An intriguing part of this study was the finding of a with a small percentage of internal resorption.192 From
total absence of cellular detail in the apical third at 3 a biologic standpoint, Magnusson felt that formocresol
weeks, but by 7 weeks, connective tissue of a granular was biologically inferior to calcium hydroxide in the
type had ingrown through the apical foramen. In spec- pulpotomy technique as the latter manifested true signs
imens obtained after longer postoperative periods, of healing but in a low percentage in primary teeth.192
granulation tissue progressively replaced the necrotic Ranley and Lazzari concluded, however, that variations
pulp tissue up to the coronal area. Small areas of in the interpretation of histologic studies with
resorption of the dentinal walls were also being formocresol, on either vital or nonvital tissue, are attrib-
replaced by osteodentin.187 utable to the length of exposure of the radicular tissue
Spamer also conducted a histologic study of to the drug, but there is no true healing.193
caries-free human primary canines following a In general, the results of many histologic studies on
one-appointment formocresol pulpotomy in which the formocresol pulpotomy have shown that several
the final pulp covering was ZOE.188 Again, the three distinct zones are usually present in the pulp following
typical zones were distinguishable, including the api- the application of the medicament:
1. Superficial debris along with dentinal chips at the dence of a root canal obliteration process. In a later
amputation site study with rhesus monkeys, using full-strength
2. Eosinophil-stained and compressed tissue formocresol compared with a 20% dilution, these
3. A palely stained zone with loss of cellular definition investigators found the same premature root resorp-
4. An area of fibrotic and inflammatory activity tion but a milder pulpal inflammatory response with
5. An area of normal-appearing pulp tissue considered the diluted concentration.204 Garcia-Godoy, however,
to be vital did not find any differences histologically between full-
strength and a one-fifth dilution of formocresol when
Formocresol Addition to Sub-base. Beaver et al. applied in several ways over the amputated pulps.195
investigated the differences in pulp reactions between a Outcomes. Citing an 80% success rate of primary
5-minute application of formocresol using sub-bases of molars pulpotomized with formocresol, Wright and
either ZOE cement alone or with the addition of Widmer also found early root resorption of the pulpo-
formocresol.194 There was no appreciable difference in tomized molars in comparison to the untreated
a histologic reaction of the remaining radicular pulp antimeres.205 The permanent successors, however, were
tissue under either of these two types of sub-bases. not found to erupt significantly earlier, as has been pre-
An alternative procedure reported clinically and his- viously reported.
tologically successful is to incorporate diluted The hard tissue deposition or calcification of the
formocresol into the ZOE dressing and then place it on root canal walls following a formocresol pulpotomy
the pulpal stumps instead of a moistened formocresol has also been observed radiographically in several
cotton pellet.17,195,196 Ranly and Pope have shown in other studies.203,206,207 These findings imply that the
vitro and in vivo that formocresol can leach out from a use of formocresol does not result in a complete loss of
ZOE sub-base when the two substances are com- pulp vitality.
bined.197 They have suggested that the initial applica- More recently, the findings of a retrospective radi-
tion of a formocresol-saturated cotton pellet on the ographic study of the formocresol pulpotomy tech-
pulp might be an unnecessary step. nique with a post-treatment time ranging from 24 to
Formocresol Dilution. Venham suggested that 87 months were reported by Hicks et al.196 In this
formocresol might be reduced to one-quarter strength study, a ZOE paste into which full-strength formocre-
in the pulpotomy application.198 The combined investi- sol was incorporated was placed in the pulp chamber
gations of Straffon and Han199,200 and Loos et al.201 on after coronal amputation followed by restoration with
the histologic and biochemical effects of formocresol a stainless steel crown. Based on radiographic evalua-
introduced new thinking in this type of pulp therapy. tion criteria, which included abscess formation, radi-
Straffon and Han concluded from a study of connective olucencies, pathologic root resorption, calcific meta-
tissue in hamster pulps exposed to formocresol that the morphosis, and advanced or delayed exfoliation, the
medicament does not interfere with a prolonged recov- procedure was considered to be successful in 93.8% of
ery of connective tissue and may even suppress the ini- the cases. Coll et al. compared the techniques of
tial inflammatory reaction. In a later report, they con- formocresol pulpotomy versus pulpectomy in primary
cluded that formocresol at 1:5 strength might be equally incisors. They concluded that the pulpotomy was the
effective and possibly a less damaging pulpotomy agent. preferred technique for these teeth.67
Loos and colleagues concurred with the previous work
in a further study of diluted formocresol.201 Morawa and Formocresol Pulpotomy Technique in Primary Teeth
colleagues, in a 5-year clinical study of 70 cases, found Correct diagnosis is essential to ensure the clinician
that the formocresol pulpotomy, using a 1:5 concentra- that inflammation is limited to the coronal pulp.208
tion, was as effective as a full concentration and also has Biopsy studies of pulp tissue removed from the open-
the advantage of reduced postoperative complications in ing of root canals under pulpotomies have demonstrat-
the periradicular region. In only five teeth was there lim- ed the unreliability of clinical assessments in primary
ited radicular internal resorption.202 teeth.192 Radiographic examinations are therefore nec-
Fuks and Bimstein used this one-fifth dilution of essary to confirm the need for pulpotomy therapy in
formocresol in a clinical and radiographic study of pri- primary teeth. It is judicious to take bitewing and peri-
mary teeth over a period of 4 to 36 months.203 The clin- radicular radiographs so that the depth of caries may
ical success rate was reported at 94.3%, and 39% of 41 be observed and the condition of the periradicular tis-
cases showed a slightly higher rate of premature root sues determined. Mejare found only a 55% success rate
resorption. Twenty-nine percent had radiographic evi- in primary molars with either coronal or total chronic
A B
Figure 17-10 One-appointment formocresol pulpotomy. A, Root of the pulp chamber and coronal pulp removed. Cotton pellet with
formocresol in place for 5 minutes. B, Successful formocresol pulpotomy 1 year following treatment. (A courtesy of Dr. Constance B. Greeley;
B courtesy of Dr. Mark Wagner.)
A B
C D
Figure 17-12 Step-by-step technique in one-appointment formocresol pulpotomy. A, Exposure of pulp by roof removal. B, Coronal pulp
amputation with a round bur. Hemostasis with dry cotton or epinephrine. C, Application of formocresol for 1 minute. Excess medicament
is expressed from cotton before placement. D, Following formocresol removal, zinc oxideeugenol base and stainless steel crown are placed.
tive children to minimize chair time, especially for the 3. At the second visit, the temporary filling and cotton
initial operative visit.211 pellet are removed and the chamber is irrigated with
Contraindications. This technique should not be hydrogen peroxide.
done for teeth that are (1) nonrestorable, (2) soon to be 4. A ZOE cement base is placed.
exfoliated, or (3) necrotic. 5. The tooth is restored with a stainless steel crown. As
previously stated, Verco and Allen found no differ-
Procedure. ence in the success rate between one-stage and
1. The steps are the same as for the one-appointment two-stage procedures.212
procedure through step 6.
2. A cotton pellet moistened with diluted formocresol Avram and Pulver surveyed Canadian, American,
is sealed into the chamber for 5 to 7 days with a and selected dental schools throughout the world as
durable temporary cement. well as a limited number of pediatric dental specialists
formocresol pulpotomy.218 Ninety-one percent fied a fallacy in extrapolating its success in primary
required no further treatment. In the remaining 9%, teeth to its use in permanent teeth.224 A consistent
the initial use of formocresol did not prevent endodon- finding in pulpotomized primary teeth has been the
tic therapy at a later date. The age of the patients at the ingrowth of connective tissue through the apex in a
start of treatment had no significant effect. coronal direction through the pulpal areas of chroni-
Spedding, in discussing the use of formocresol for cally inflamed and fibrosed tissue. He identified that
permanent molars, stated that a plug of fixed tissues favorable clinical responses could mask the reality of
forms in the root canals that can easily be removed histologic pulpal degeneration. Late symptoms from
with endodontic instruments.219 This is in contrast to pulp degeneration in pulpotomized primary teeth are
teeth treated with calcium hydroxide. He concluded, eliminated owing to their exfoliation. Young perma-
however, that although few failures with formocresol nent teeth, however, may have a greater potential for
had been reported in permanent teeth, this treatment developing periradicular infection with this technique
rationale is empirical, and more definite information owing to the longer time exposure to the inflammatory
about failures is needed. degenerative process. Conversely, he hypothesized that
Rothman observed 165 pulpotomized human perma- the formocresol treatment might be effective because
nent teeth for 2 years with a two-treatment formocresol the open apical foramen of immature permanent teeth
medication.220 He reported an average success rate of would be conducive to an ingrowth of connective tissue
71% as judged clinically and radiographically. Intracanal at the apex in the form of proliferating fibroblasts.224
calcification was seen in only three teeth. Because linear osteodentin calcification may develop
Fuks et al., in studying radiographs of formocresol as a response to formocresol pulpotomies over time,
pulpotomies in young permanent teeth of monkeys at there has been considerable concern expressed by
the end of 1 year, observed a favorable response with both endodontists of the difficulty in renegotiating treated
full-strength and diluted medication for continuing root young permanent canals after the apices have closed.
development and closed apices.204 Histologically, mild
internal resorption was seen at a later date. The investiga- Calcium Hydroxide
tors stated that neither concentration produced ideal Calcium hydroxide was most favored as a pulpotomy
results, but a milder degree of inflammation was seen in agent in the 1940s and mid-1950s because it was
the diluted group. thought to be more biologically acceptable owing to
Schwartz, surveying a group of Canadian practition- the fact that it promoted reparative dentin bridge for-
ers and faculty on the use of formocresol for pulpo- mation and pulp vitality was maintained. This ration-
tomies in young permanent teeth, found that the ale was introduced by Teuscher and Zander in 1938,
respondents felt that the procedure was a compromise who described it as a vital technique.225 Their histo-
and that the teeth should be treated with conventional logic studies showed that the pulp tissue adjacent to the
endodontics at a later date.221 calcium hydroxide was first necrotized by the high pH
Muniz et al. histologically studied 26 young perma- (11 to 12) of the calcium hydroxide. This necrosis was
nent teeth treated with the formocresol technique 5 to accompanied by acute inflammatory changes in the
20 months postoperatively.222 This investigation was underlying tissue. After 4 weeks, a new odontoblastic
based on an earlier study by Muniz in which he found layer and, eventually, a bridge of dentin developed
an overall success rate of 92% in both vital and nonvital (Figure 17-13). Later investigations showed three iden-
permanent teeth. He found inflammation and necrosis tifiable histologic zones under the calcium hydroxide in
in the cervical third but fibrosis and osteodentin pre- 4 to 9 days: (1) coagulation necrosis, (2) deep-staining
dominantly in the apical third, a response that seems to basophilic areas with varied osteodentin, and (3) rela-
indicate stages of biologic scar healing that probably tively normal pulp tissue, slightly hyperemic, underly-
require around 10 to 20 months to be seen. ing an odontoblastic layer.
Akbar investigated the differences in formocresol As with direct pulp capping, the presence of a denti-
pulpotomy in permanent teeth with acute and chronic nal bridge is not the sole criterion of success. The
pulpitis over a 5-year period.223 On the basis of clinical bridge may be incomplete and may appear histologi-
criteria only, he found the treatment to be more suc- cally as doughnut, dome, or funnel shaped or filled
cessful in the acute pulpitis group (81%) than in the with tissue inclusions.226,227 It is also possible for the
chronic pulpitis group (70%). remaining pulp to be walled off by fibrous tissue with
In reviewing the literature on apical histologic no dentin bridge evident radiographically. Initial
response to formocresol pulpotomies, Nishino identi- reports by Berk and Brown indicated a success rate
A B
Figure 17-13 Calcium hydroxide pulpotomy, young perma-
nent molar. A, Pulp of a first permanent molar exposed by
caries (white arrow). B, Calcified dentin bridges (arrows) over
vital pulp in canals. Note open apices. C, Pulp recession
(arrows) and continued root development indicative of contin-
uing pulp vitality. Reproduced with permission from
McDonald RE. Dentistry for the child and adolescent. 2nd ed.
St. Louis: CV Mosby; 1974.
with calcium hydroxide for primary and young perma- Histologic study revealed extra pulpal blood clots, over
nent teeth in the range of 30 to 90%.228,229 the amputated sites, which Schrder felt interfered with
pulpal healing and dentin bridge formation.
Calcium Hydroxide Pulpotomy Outcomes in In spite of these earlier discouraging reports, Phaneuf
Primary Teeth et al. demonstrated significant primary tooth pulpoto-
Via, in a 2-year study of calcium hydroxide pulpo- my success with calcium hydroxide in commercial
tomies in primary teeth, had only a 31% success,230 and preparations such as Pulpdent (Pulpdent Corporation
Law reported only a 49% success in a 1-year study.231
In all investigations, failure was the result of chronic
pulpal inflammation and internal resorption.
Magnusson192 and Schrder and Granath232 found
similar high failure rates with calcium hydroxide in
pulpotomized primary molars.
Internal resorption may result from overstimulation
of the primary pulp by the highly alkaline calcium
hydroxide. This alkaline-induced overstimulation
could cause metaplasia within the pulp tissue, leading
to the formation of odontoclasts (Figure 17-14). In
addition, undetected microleakage could allow large
numbers of bacteria to overwhelm the pulp and nullify
the beneficial effects of calcium hydroxide.
Schrder also evaluated the progress of 33 pulpo-
tomized primary molars with calcium hydroxide as a
wound dressing.233 After 2 years, the success rate was Figure 17-14 Massive internal resorption (arrows) of primary
59%, with failures manifested as internal resorption. mandibular molars after calcium hydroxide pulpotomy.
of America; Watertown, Mass.) and Dycal.106 The dif- 2. Excavate all caries and establish a cavity outline.
ference in pulp response to these commercial prepara- 3. Irrigate the cavity with water and lightly dry with
tions might be attributed to their lower pH values. cotton pellets.
Calcium hydroxide incorporated in a methylcellulose 4. Remove the roof of the pulp chamber with a
base, such as Pulpdent, showed earlier and more consis- high-speed fissure bur.
tent bridging than did other types of calcium hydroxide 5. Amputate the coronal pulp with a large low-speed
preparations. Berk and Krakow234 and Schrder233 have round bur or a high-speed diamond stone with a
extensively studied calcium hydroxide pulpotomies and light touch.237
believe that the state of the pulp, surgical trauma, or 6. Control hemorrhage with a cotton pellet applied with
amputation treatment may be more important than the pressure or a damp pellet of hydrogen peroxide.
calcium hydroxide per se in inducing success. At pres- 7. Place a calcium hydroxide mixture over the radicu-
ent, the calcium hydroxide pulpotomy technique can- lar pulp stumps at the canal orifices and dry with a
not be generally recommended for primary teeth cotton pellet.
owing to its low success rate.89,184,235 8. Place quick-setting ZOE cement or resin-reinforced
glass ionomer cement over the calcium hydroxide to
Permanent Tooth Pulpotomy: Indications seal and fill the chamber.
and Contraindications 9. If the crown is severely weakened by decay, a stain-
Because of improved clinical outcomes, calcium less steel crown rather than an amalgam restoration
hydroxide is the recommended pulpotomy agent for should be used to prevent cusp fractures (Figure 17-
carious and traumatic exposures in young permanent 16).
teeth, particularly with incomplete apical closure
(Figure 17-15). Following the closure of the apex, it is ALTERNATIVES TO FORMOCRESOL IN
generally recommended that conventional root canal PRIMARY TEETH
obturation be accomplished to avoid the potential Although diluted formocresol is currently the recom-
long-term outcome of root canal calcification.236 mended agent for pulpotomy treatment for carious
pulp exposures in vital primary teeth, some concern
Procedure. has been expressed regarding its use as a pulp medica-
1. Anesthetize the tooth to be treated and isolate under tion because of its biocompatibility deficiencies. The
a rubber dam. formaldehyde component of the medicament and its
A B
Figure 17-15 Calcium hydroxide pulpotomies in young permanent teeth. A, Crown fracture exposure of a central incisor. The apex was
open at the time of pulpotomy. Note root growth, apical closure, and the dentin bridges (arrows). B, Partial root canal calcification (arrows)
following pulpotomy in a young first permanent molar.
Glutaraldehyde
It was suggested by s-Gravenmade that formaldehyde
did not represent the ideal pulp fixative in clinical
Figure 17-16 Calcium hydroxide pulpotomy in a young perma- endodontic therapy. Inflamed tissue that produces
nent molar. The cavity is prepared, caries and the chamber roof are toxic by-products should be fixed rather than treated
removed, and the pulp is amputated to the canal orifices. Following with strong disinfectants.248 He felt that satisfactory
hemostasis, commercial calcium hydroxide is placed and protected fixation with formocresol requires an excessive amount
with zinc oxideeugenol and amalgam filling or a stainless crown. of medication, as well as a longer period of interaction.
A, Vital pulp. B, Calcium hydroxide. C, Zinc oxideeugenol
quick-set cement. D, Amalgam.
These requirements may lead to undesirable effects at
the periapex.
Also, the reactions of formaldehyde with proteins
close derivatives have been implicated for exerting should be considered less than stable and may be
potentially harmful systemic and local effects. reversible. He felt that a glutaraldehyde solution might
Formocresol may not be confined solely to the radic- replace formocresol in endodontic therapy because of
ular tissue. Various investigations by Pashley et al.238 and its fixative properties and bactericidal effectiveness and
Myers et al.239 showed systemic uptake and tissue injury result in less destruction of tissue.
of labeled formaldehyde that was later found in dentin, Hill et al. compared glutaraldehyde to formocresol
periodontal tissue, bone, plasma, kidneys, and lungs. in vitro with respect to its antimicrobial and cytotoxic
Ranly and Horn, in studying the ingredients and actions effects. Minimal antimicrobial concentrations were
of formocresol, stated that although high levels of 3.125% for glutaraldehyde and 0.75% for formocresol.
formaldehyde or cresol can be mutagenic or carcino- More importantly, at these concentrations, glutaralde-
genic and produce histologic failures pulpally, it is not hyde was found to be less cytotoxic when used as a
realistic that enough multiple pulpotomies would be pulpotomy agent. Formocresol at its lower concentra-
performed to bring about a toxic systemic level.240,241 tion, however, was considerably more antimicrobial
Messer et al. reported a significant number of enam- than glutaraldehyde.249
el defects in the succedaneous teeth under formocresol Wernes and s-Gravenmade, in an in vivo study of
pulpotomies.242 Rollings and Paulsen243 and Mulder et permanent and primary dentitions, in which some
al.,244 however, found no difference in the prevalence of teeth were vital and others nonvital, found no evidence
enamel defects in permanent teeth in relation to of periradicular inflammation after the application of
formocresol pulpotomies. glutaraldehyde.250 Dankert and colleagues found only
Because of the potential concerns in the use of minimal diffusion through the apices.251
formaldehyde in dentistry, it has been suggested that The following attributes have been ascribed to glu-
research in alternative formulations be conducted for taraldehyde as a more desirable medicament for pulpal
use in pediatric pulpal therapy.245 In spite of these con- therapy when compared to formocresol: (1) it is a
cerns, formocresol remains as the benchmark medica- bifunctional reagent, which allows it to form strong
ment to which alternative agents are compared. intra- and intermolecular protein bonds, leading to
Ranly et al. also investigated the systemic distribu- Severe inflammation was noted in 35% of the ferric
tion of 4% infused glutaraldehyde pulpotomies in rats sulfate group versus 29% of the diluted formocresol
and found only an approximate 25% of the applied group. Abscess and necrosis were noted in 3% of the
dose. These investigators concluded that the use of glu- ferric sulfate group versus 13% of the diluted
taraldehyde as a pulpotomy agent in humans would be formocresol group. They concluded that histologic
free of any significant toxicity.265 results were similar for both groups and did not com-
pare favorably with previously reported clinical find-
Astringents ings of ferric sulfate potential superiority.271
Schrder and Granath documented the fact that pulpal
hemorrhage control is critical for pulpotomy suc- Cell-Inductive Agents
cess.232 Kouri et al. compared formocresol pulpotomies Mineral trioxide aggregate and calcium phosphate
in primary teeth using epinephrine versus sterile water cement have already been described with respect to
and cotton pellets for hemorrhage control. After 6- their potential cell-inductive properties in the context
week to 3-month post-treatment periods, histologic of direct pulp-capping techniques. Their use in pulpo-
and electron microscopic evidence of healing was sim- tomy techniques remains to be substantiated from con-
ilar for both groups. Bleeding times for the epineph- trol studies. Mineral trioxide aggregate was identified
rine-treated pulps were 50 seconds versus 251 seconds as a potentially effective pulpotomy agent in a review of
for the sterile watertreated pulps. Less extravasated this material with case examples by Abedi and Ingle.272
blood occurred with the epinephrine-treated pulps and Higashi and Okamoto reviewed the use of calcium
was limited to the amputation site. No clinical or radi- phosphate ceramics and hydroxyapatite as potential
ographic failures occurred for either group.266 pulpotomy agents. They studied the particle size effects
Helig et al. compared aluminum chloride versus of hydroxyapatite and -tricalcium phosphate as vari-
sterile water in achieving hemostasis prior to medica- ables in pulpotomy success as determined by hard tis-
ment placement in calcium hydroxide pulpotomies for sue formation. Osteodentin and tubular dentin forma-
primary teeth in humans. They found a 25% radi- tion occurred around large particles (300 mu) in con-
ographic failure rate in the sterile water group versus trast to small particles (40 mu), which demonstrated
no radiographic failures with the aluminum chloride pulp tissue inflammation.273 Yoshiba et al. provided
group after 9 months.267 evidence of -tricalcium phosphate in combination
Ferric sulfate has received the most recent attention with calcium hydroxide being successful in bridge for-
as a formocresol alternative in pulpotomy choices. This mation with less local destruction of pulp tissue than
material, when in contact with tissue, forms a ferric with calcium hydroxide alone.274
ion-protein complex that mechanically occludes capil- Bone morphogenetic proteins have been proposed as
laries at the pulpal amputation site. The subjacent pulp potential capping agents in direct pulp-capping and
tissue is then allowed to heal. Landau and Johnson pulpotomy techniques. Bone morphogenetic proteins 2
found a more favorable pulpal response to a 15.5% fer- to 8 belong to TGF-, that are signaling proteins that reg-
ric sulfate solution than calcium hydroxide in primate ulate cell differentiation. Bone morphogenetic proteins 2
pulpotomies after 60 days.268 Fei et al. found a com- and 4 have been implicated in odontoblastic differentia-
bined clinical and radiographic success rate of 96.3% tion. Nakashima demonstrated dentin bridging in dog
for ferric sulfate pulpotomies versus a 77.8% success tooth coronal pulp amputation when the remaining tis-
rate for diluted formocresol pulpotomies in humans sue was capped with BMP-2 and BMP-4, along with
after 12 months.269 recombinant human dentin matrix. After a 2-month
Fuks et al. found a 92.7% success rate with ferric time interval, tubular dentin and osteodentin were found
sulfate versus 83.8% with diluted formocresol in pri- histologically in response to both BMP types.177
mary tooth pulpotomies after a mean post-treatment Fadhavi and Anderson compared freeze-dried bone,
time of 20.5 months. They noted that these differences calcium hydroxide, and ZOE in primate deciduous
were not statistically significant and therefore conclud- tooth pulpotomies with respect to histologic inflam-
ed the success rates to be similar for both groups.270 mation and clinical/radiopathic pathology. After 6-
Fuks et al. conducted a histologic study of ferric sulfate week and 6-month time periods, vital pulps with mod-
versus diluted formocresoltreated pulps in primate erate inflammation were found in 83.3% of the freeze-
teeth at 4- and 8-week observation periods. Mild dried bone group. This was in contrast to the calcium
inflammation was evident in 58% of the ferric sulfate hydroxide group, which demonstrated moderate to
group versus 48% of the diluted formocresol group. severe inflammation in 50% of the cases and signs of
partial necrosis in 100%. Dentin bridge formation Morton histologically studied the effects of electrosur-
occurred in 100% of the freeze-dried bone group ver- gical pulpotomies on the remaining radicular tissue in
sus 50% in the calcium hydroxide group. All of the 11 primary canines at 6-day, 2-week, 8-week, and 13-
ZOE-treated teeth were necrotic at 6 months. They week post-treatment intervals. Varying degrees of
concluded that freeze-dried bone was superior to calci- inflammation, edema, and necrosis were seen at all
um hydroxide within the parameters of their study and time periods, with the most favorable tissue appearance
might have potential as a pulpotomy agent if substan- occurring at the longer intervals. Those teeth judged to
tiated by studies in humans.178 be successful demonstrated reparative dentin forma-
tion along the lateral aspect of the radicular canal walls
Nonpharmacotherapeutic Pulpotomy Techniques: but not across the amputation site. They concluded
Controlled Energy that their results did not support the concept of elec-
Controlled energy in the form of electrosurgical and trosurgery being less harmful to pulp tissue than con-
laser heat application to the pulp stumps at the canal ventional pharmacotherapeutic techniques.278
orifice site has been proposed as an alternative to the A form of electrosurgery, known as electrofulgura-
more traditional pharmacotherapeutic techniques, tion, has been suggested for pulpotomies in primary
particularly those using formocresol. Ruemping et al. teeth.279 It involves establishing an electrical arc to the
identified electrosurgical pulpotomy advantages that targeted tissue without direct contact of the probe,
can be applied to the controlled energy category at which ideally confines heat to the superficial tissue level.
large and include (1) quick and efficient, (2) self-limit- Mack and Dean investigated the electrofulguration
ing, (3) good hemostasis, (4) good visibility of the field, pulpotomy technique in 164 primary molars.279 After a
(5) no systemic effects, and (6) sterilization at the site 26-month post-treatment period, they found a 99.4%
of application.275 clinical and radiographic success rate. They felt that this
Electrosurgery. Ruemping et al. histologically compared favorably with a 93.9% formocresol pulpoto-
compared electrosurgery with formocresol in pulpoto- my success rate in a retrospective study by Hicks et al.
my techniques for primate primary and young perma- with a similar protocol.196,279 Conversely, Fishman et al.
nent teeth. They mechanically amputated coronal compared calcium hydroxide with ZOE when used as a
pulps and then either applied formocresol to the pulp base over electrofulgurated pulp tissue. Although the
stump or performed momentary electrosurgery, fol- overall clinical success rate for the entire sample was 77
lowed by ZOE cement placement.275 After an 8-week to 81%, the radiographic success was 57.3% for the elec-
post-treatment period, the histologic appearance for trofulguration plus calcium hydroxide group and 54.6%
both groups was similar, with no evidence of pulp for the electrofulguration plus ZOE group.280
necrosis or abscess formation. In the electrosurgery Lasers. Application of laser irradiation in vital
group, secondary dentin was deposited along the later- pulp therapy has been proposed as another alternative
al canal walls, and the apical two-thirds of the pulp to pharmacotherapeutic techniques. Its advantages and
revealed a slightly fibrotic to normal appearance.275 disadvantages are the same as for electrosurgery.
Shaw et al. compared, after 6 months, the histologic Adrian reported that irradiation of the buccal tooth
effects of electrosurgery with formocresol on the radic- surface with the neodymium: yttrium-aluminum-gar-
ular pulp. They found similar success rates of 80% for net (Nd:YAG) laser produced less pulp damage than
the formocresol and 84% for the electrosurgical groups the ruby laser with less histologic evidence of coagula-
according to their histologic criteria. They concluded tion and focal necrosis.281 Shoji et al. histologically
that neither technique was superior.276 studied the carbon-dioxide laser in the pulpotomy pro-
Conversely, Shulman et al. histologically compared cedure. They noted that the least amount of pulp tissue
electrosurgery, formocresol, and electrosurgery plus injury occurred with defocused irradiation with lower
formocresol in primate pulpotomies.277 They used power settings and shorter application. More tissue
14C-labeled formocresol and performed coronal ampu- destruction occurred in the defocused mode with high-
tation with electrosurgery subsequent to pulp chamber er irradiation power settings.282 Kato et al. studied the
roof removal. They found more periradicular and fur- effects of the Nd:YAG laser on pulpotomized rat molars
cal pathologic change after 65 days in the electro- at low (5 watts) and high (15 watts) power settings. At
surgery group. They also noted that combining the two 2 weeks, histologic evidence showed osteodentin cover-
techniques of electrosurgery and formocresol pro- ing the amputated pulps with the low power setting
duced no better results. Both electrosurgical groups and fibrous dentin formation at the orifice wall of the
were inferior to the formocresol group.277 Sheller and root canal with the high power setting. Normal root
development was observed in all specimens.283 Marsh and Largent indicated that the goal of the
McGuire et al. compared the Nd:YAG laser with pulpectomy procedure in primary teeth should be to
formocresol in permanent tooth pulpotomies in dogs eliminate the bacteria and the contaminated pulp tis-
at 6- and 12-week post-treatment periods. No signifi- sue from the canal.292 In primary teeth, more empha-
cant differences in radiographic pathology were found sis is placed on chemical means in conjunction with
between the two groups. Histologically, the frequency limited mechanical dbridement to disinfect and
of pulpal inflammation was higher for the laser group remove necrotic pulp remnants from the somewhat
(29%) at 12 weeks than for the formocresol group inaccessible canals rather than conventional shaping
(0%). No differences were found with respect to peri- of the canals. Complete pulpectomy procedures have
radicular inflammation and root resorption.284 been recommended for primary teeth even with evi-
Studies on controlled-energy pulpotomy techniques dence of severe chronic inflammation or necrosis in the
are equivocal as to their effectiveness in reducing post- radicular pulp.293295
treatment inflammation when compared to conven- Resorbable cements such as ZOE and iodoform-
tional pharmacotherapeutic techniques. Although clin- containing pastes have been recommended as canal
ical reports of success exist, more controlled clinical obturants. Nonresorbable materials such as gutta-per-
and histologic investigations are needed to address the cha and silver points are contraindicated as they will
variables of power settings, application times, continu- not enhance the primary root physiologic resorptive
ous versus pulsed modes of application, and degree of process (Figure 17-18). Rifkin identified criteria for an
heat dissipation in the radicular pulp and surrounding ideal pulpectomy obturant that include it being (1)
hard tissues. resorbable, (2) antiseptic, (3) noninflammatory and
nonirritating to the underlying permanent tooth germ,
NONVITAL PULP THERAPY IN PRIMARY (4) radiopaque, (5) easily inserted, and (6) easily
TEETH: PULPECTOMY removed.296 No currently available obturant meets all
The treatment objectives in nonvital pulp therapy for of these criteria.
primary teeth are to (1) maintain the tooth free of Owing to primary tooth exfoliation, the standard for
infection, (2) biomechanically cleanse and obturate the long-term pulpectomy success is shorter than for adult
root canals, (3) promote physiologic root resorption, endodontics. Primary tooth pulpectomies are success-
and (4) hold the space for the erupting permanent ful if the root is (1) firmly attached, (2) remains in
tooth. The treatment of choice to achieve these objec- function without pain or infection until the permanent
tives is pulpectomy, which involves the removal of successor is ready to erupt, (3) undergoes physiologic
necrotic pulp tissue followed by filling the root canals resorption, and (4) is free from fistulous tracts.
with a resorbable cement. Indications for this proce- Radiographically, success is judged by the absence of
dure include teeth with poor chance of vital pulp treat- furcation or periradicular lesions and the re-establish-
ment success, strategic importance with respect to ment of a normal periodontal ligament.
space maintenance, absence of severe root resorption,
absence of surrounding bone loss from infection, and Historical Perspective
expectation of restorability. Sweet described a four- or five-step technique using
Most negative attitudes toward primary teeth com- formocresol for the treatment of pulpless teeth with
plete pulpectomy have been based on the difficulty in and without fistulae.180 A study of pediatric endodon-
cleaning and shaping the bizarre and tortuous canal tic procedures was reported by Rabinowitz in which
anatomy of these teeth.285,286 This was especially true nonvital primary molars were treated with a 2- to 3-day
for primary molars with their resorbing and open application of formocresol, followed by precipitation
apices.287,288 Removal of abscessed primary teeth has of silver nitrate and a sealer of ZOE cement into the
been suggested because of their potential to create canals.297,298 Although he reported a high success rate,
developmental defects in the underlying permanent his complicated procedure involved a range of 4 to 17
successors.289291 In spite of these objections, successful visits, with an average of 5.5 visits for teeth without
root canal obturation of irreversibly inflamed and non- periradicular involvement and 7.7 visits for those with
vital primary teeth can be successfully accomplished. periradicular involvement.
Modifications of adult endodontic techniques, howev- Hobson described pulpectomy techniques for
er, must be implemented because of the aforemen- necrotic primary teeth in which the canals were not
tioned anatomic differences between primary and per- dbrided. Beechwood creosote was used as a disinfec-
manent teeth. tant, usually for 2 weeks, followed by filling the pulp
A B
Figure 17-18 Root canal filling of a pulpless, maxillary primary lateral incisor. A, Carious exposure and pulp deatha candidate for
endodontic therapy. B, Six months following successful root canal filling with resorbable zinc oxideeugenol cement. Care must be taken not
to perforate the apex or overfill and injure the developing permanent tooth bud. Reproduced with permission from Law DB, Lewis TM, Davis
JM. An atlas of pedodontics. Philadelphia: WB Saunders; 1969.
chamber with a ZOE cement. Treatment proved equal- Lentulo paste filler.300 After water irrigation and air
ly successful for teeth with necrotic pulps or vital drying, canals were obturated with a thin mix (viscosi-
infected pulps.299 ty similar to toothpaste) of a fine-grained, nonrein-
In treating primary molars, Lewis and Law used forced ZOE cement (ZOE 2200, Dentsply-Caulk;
conventional endodontics in canal preparation where Milford, Dela.) using a Lentulo spiral paste filler.300
they instrumented, irrigated with sodium hypochlo- Gould reported a clinical study of primary teeth in
rite, and dried the canals, which were then medicated 27 children, age 312 years to 812 years, using a
for 3 to 7 days with either eugenol, camphorated one-appointment technique.301 In 35 frankly infect-
parachlorophenol, or formocresol.1 On the second ed primary molars, a cotton pellet of camphorated
visit, the canals were mechanically prepared with files parachlorophenol was placed in the chamber for 5
and filled with one of various resorbable mixtures, such minutes after the canals had been dbrided with files
as ZOE cement or ZOE mixed with iodoform crystals over two-thirds of their length. Zinc oxideeugenol
(see Figure 17-18). cement was then pressed into the prepared canals. After
Judd and Kenny advocated a different complete 26 months of clinical and radiographic observation,
pulpectomy method for deciduous teeth.300 For vital 83% were judged to be therapeutically successful on the
pulp extirpation, two Hedstroem files, usually size 20, basis of no lesions being detected.
were slid along opposite sides of the canal to entangle In asymptomatic necrotic primary teeth, Frigoletto
pulp tissue. Ideal placement of the files just short of the suggested that canals be dbrided with a barbed
apex, with two or three rotations, will ensnare the pulp. broach, irrigated with sodium hypochlorite, and dried.
When withdrawn, the vital pulp will be removed in toto. Canals were then filled with root canal paste using a
If the pulp has degenerated, then the canal should be specially designed pressure syringe.75 In instances of
filed with a single No. 20 to allow access for a red No. 1 symptomatic teeth, Cresatin was mixed with the paste.
Starkey has described a one-appointment and two-sitting pulpectomy procedures. Coll et al. reported
multiappointment method of treating cariously an 80 to 86% success rate with the one-sitting tech-
involved primary pulp tissue.91 The one-appointment nique.307 Primosch et al. noted that 60% of US under-
method is used in cases with vital pulp tissue, in which graduate dental programs teach the one-sitting technique
inflammation extends beyond the coronal pulp and no versus 26% teaching the two-sitting technique.69
radiographic evidence of periradicular involvement is Extension of formocresol use to the pulpectomy
present. In these cases, Starkey recommended a partial technique was a logical sequence. Vander Wall et al. have
pulpectomy to remove the coronal aspects of the radic- shown formocresol to be more effective than either
ular pulp, controlling hemorrhaging and filling the camphorated parachlorophenol or Cresatin as a root
canals and crown with a creamy mix of ZOE cement. canal medicament for inhibiting bacterial growth.308
Starkeys multiappointment method was advocated Several studies have evaluated the clinical and radi-
for cases with necrotic pulps and periradicular ographic findings of the pulpectomy procedure for
involvement.91 At the first appointment, coronal pulp nonvital primary molars and primary anteriors using
debris is removed, but the canals are not instrumented. formocresol. Coll et al. evaluated a one-appointment
A medicament such as formocresol or camphorated formocresol pulpectomy technique for nonvital pri-
monochlorophenol is placed in the pulp chamber and mary molars. After a mean observation period of 70
sealed with IRM for 1 week. If the tooth and surround- months, 86.1% were judged successful.307 They also
ing gingival tissues are asymptomatic and clinically found that successful pulpectomized primary molars
negative at the second visit, the canals are mechanical- were not over-retained and the successor premolars had
ly cleansed and dbrided and then filled with ZOE a very low incidence of hypoplastic defects.307
cement (Figure 17-19). Modifications of these proce- Barr et al., in a radiographic retrospective evaluation
dures have been described by Cullen,302 Dugal and of primary molar pulpectomies performed in a private
Curgon,303 Goerig and Camp,304 Kopel,305 Mathewson practice with a mean observation period of 40.2
and Primosch,89 and Spedding.306 months, found an overall success rate of 85.5%.309
It should be noted that some controversy exists with Noteworthy findings included 88% complete ZOE
respect to the relative effectiveness of the one-sitting and paste resorption and a 25.8% reduction of preoperative
radiolucencies. These clinicians suggested that posteri- obturation. As previously mentioned, there has been
or primary molar pulpectomies have a relatively high concern about the use of formocresol in any form in
success rate in private practice. pediatric endodontic therapy. Alternative pulpectomy
Coll et al. and Flaitz et al. also evaluated the results of agents have been proposed to improve on the biocom-
pulpectomy treatment in primary anterior teeth.310,311 patibility limitations of ZOE and formocresol.
Using clinical and radiographic evaluations, Coll and Hendry et al. compared calcium hydroxide with
colleagues completed 27 pulpectomies in primary inci- ZOE as a pulpectomy obturant in primary teeth of
sors and found that their 78% success rate did not differ dogs. At 4 weeks post-treatment, canals treated with
statistically from comparable primary molar rates after a calcium hydroxide exhibited less inflammation, less
mean of 45 months.310 Seventy-three percent were con- pathologic root resorption, and more hard tissue appo-
sidered to have exfoliated normally. These investigators sition than ZOE and control-treated teeth.314
concluded, however, that documented success rates for Barker and Lockett identified the potential benefits
indirect pulp capping and pulpotomies in primary ante- of Kri paste, an iodoform compound, also containing
rior teeth were higher than for pulpectomies. parachlorophenol, camphor, and menthol. The advan-
Flaitz et al.s contrasting study compared 57 pulpo- tages of this material include bactericidal properties
tomies versus 87 pulpectomies in primary anterior and excellent resorbability. Histologically, they found
teeth followed for a mean of 37 months.311 Based on that this material easily resorbed even when extruded
the final radiographs in the study, treatment was suc- beyond the apex of the treated teeth. An ingress of con-
cessful in 68.5% of the pulpotomized group of anteri- nective tissue was seen in the apical portions of the
or teeth versus 84% of the pulpectomized group. They treated canals.315 Bactericidal iodoform pastes have
concluded overall that pulpectomy was a better treat- been reintroduced as a root canal filling.245,316,317
ment option for primary incisors even though they Garcia-Godoy obtained a 95.6% success clinically and
may have shown more radiographic pathosis at the radiographically with Kri paste during a 24-month
time of the diagnosis. period for 43 teeth.318 It was noted that this paste
Yacobi and Kenny have twice monitored their success would resorb within 2 weeks if found in the periradic-
rates in vital pulpectomy and immediate ZOE (ZOE ular or furcation areas.319 Rifkin reported an 89% clin-
2200, L. D. Caulk Co.; Milford, Dela.) filling. At 6 months, ical and radiographic success rate after 1 year with Kri
their success rate was comparable to the formocresol paste pulpectomies in primary teeth.296 Holan and
results of 89% for anterior teeth and 92% for posterior Fuks clinically and radiographically compared Kri
teeth.312 At 2 years, reporting on 81 patients and 253 paste with ZOE in human primary molars after 48
teeth, Payne et al., using ZOE, reported a mean success months postoperatively. They found overall success
rate of 83% for anterior teeth and 90% for posterior rates of 84% with the Kri paste group versus 65% with
teeth. They conjectured that the discrepancy in rates the ZOE group. Kri paste was almost twice as success-
between anterior and posterior teeth was related to the ful in primary first molars as ZOE. However, no signif-
final restorationsmicroleakage from composite resin icant differences between these two agents occurred in
in the anterior regions and stainless crowns in the poste- primary second molars. Overfills with Kri paste result-
rior.313 They believed this to be a most acceptable alter- ed in 79% success versus 41% success with ZOE. They
native method for saving primary teeth while avoiding concluded that iodoform-containing paste had a
the compromising effects of the aldehydes. potential advantage over ZOE in the pulpectomy pro-
cedure for primary teeth.319
Alternative Pulpectomy Canal Obturants
Treatment Considerations
Zinc oxideeugenol cement has been the most fre-
quently used obturant in the pulpectomy technique. The preceding review demonstrates the varied tech-
Primosch et al. noted that 90% of US pediatric den- niques and successes for mastering pulp therapy for
tistry undergraduate programs teach ZOE as the nonvital and irreversibly inflamed primary teeth.
pulpectomy obturant of choice.69 Although considered Before outlining treatment methods, special considera-
to be resorbable, Coll et al., in a 6-year follow-up of 41 tions, indications, and contraindications must be
pulpectomized primary molars, found that ZOE parti- addressed by the clinician.
cle retention in the gingival sulcus occurred in 8 of 17
patients followed to the time of premolar eruption.307 General Considerations.
Their technique included a 5-minute formocresol- 1. The patient should be healthy and cooperative. If
blotted paper point treatment of the canals prior to any systemic disorders are present that would com-
cement. Full described complete success in 20 children has also been noted. Erausquin and Devoto have shown
with chronically abscessed primary molars and draining that formaldehyde-containing cements frequently
fistulae in a two-appointment formocresol technique.329 caused partial ankylosis at different levels of the peri-
All of the draining fistulae were reported to be resolved. odontal ligament.334 Coll and Sadrian, in a retrospective
As an extension of this technique, Meyer and Sayegh used study of pulpectomy outcomes, noted two parameters
a combination treatment of formocresol in the pulp that were the highest predictors of success.
chamber and curettage of the bifurcation to achieve an Pretreatment pathologic root resorption, when evi-
87% clinical success at 5 years postoperatively.330 dent, resulted in a 44.4% prevalence of enamel defects
In a survey of members of the American Academy of in underlying permanent teeth after their eruption. In
Pediatric Dentistry, success rates of 72% were reported the absence of pretreatment pathologic root resorption,
in nonvital primary molars that had been treated by the pulpectomy success rate was 91.7%. The quality of
cleaning only the coronal chamber and placing canal fill relative to the apex was another outcome
formocresol versus instrumenting the canals. Both determinant, with 86.5% success rates occurring for
treatments were concluded by filling the respectively canals filled short of the apex, 88.9% success for canals
cleansed areas with a resorbable medicated cement and filled to the apex, and 57.7% success for canals filled
placing a stainless steel crown.331 beyond the apex.335
Myers et al., in a recent histologic study of failed
pulpotomies in primary molars, stated that the devel- SUMMARY
opment of a furcation lesion has the potential for cys- The rationale for pediatric pulp therapy has developed
tic transformation and the tooth should be extract- out of extensive clinical studies and improved histolog-
ed.332 This conclusion also implies that pulpectomy ic techniques. Ongoing research will result in modifica-
treatment for nonvital primary molars with furcation tions that will enhance treatment outcomes.
lesions is contraindicated. A successful pediatric endodontic outcome should
be based on (1) re-establishment of healthy periodon-
Pulpectomy Outcomes tal tissues; (2) freedom from pathologic root resorp-
Negative sequelae from endodontically treated primary tion; (3) maintenance of the primary tooth in an infec-
teeth in the form of accelerated resorption and exfolia- tion-free state to hold space for the eruption of its per-
tion have been a major concern of many clinicians. manent successor; (4) in the case of young permanent
Starkey felt that delayed eruption of the permanent suc- teeth, maintenance of the maximum amount of nonin-
cessors sometimes followed pulpotomy and pulpecto- flamed portions of pulp tissue to enhance apexogenesis
my treatment of primary molars, with some possible and root dentin formation. With adherence to sound
deflection in the eruption path.333 This sequela was not principles in case selection and techniques, pediatric
seen in the studies by Barr et al.309 and Coll et al..310 pulp therapy is a major health benefit to the child. The
Ankylosis of the primary tooth with a root canal filling treatment modalities and medicaments that have been
discussed are summarized in Table 17-2, highlighting 23. Rayner JA, Southam II. Pulp changes in deciduous teeth asso-
the most substantiated and qualifying those that need ciated with deep carious dentin. J Dent 1970;7:39.
24. Taylor B, et al. Response of the pulp and dentine to dental
further confirmation by additional research. The clini-
caries in primary molars. J Int Assoc Dent Child 1971;2:3.
cian must realize that these recommendations are not 25. Damele J. Clinical evaluation of indirect pulp capping: a
absolute and will continue to be modified. progress report. J Dent Res 1961;40:756.
26. Belanger G K. Pulp therapy for young permanent teeth. In:
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Chapter 18
PHARMACOLOGY FOR
ENDODONTICS
Paul D. Eleazer
Infections concur with many endodontic conditions. In the usual scenario, pulpal invasion begins with a
Accordingly, it behooves the practitioner to be well pre- mixed infection of aerobes and anaerobes. As the infec-
pared to use drugs that help fight infection. tion continues, oxygen is depleted, and obligate anaer-
Unfortunately, pain has also become associated with obic bacteria and facultative bacteria predominate.2
endodontics, at least in the publics mind. Fortunately, for For many years, endodontists suspected bacteria as the
both pre- and postoperative pain, relief through drugs is pathogens in necrotic pulps but were not able to prove
readily available. In addition to pain, anxiety about the point because of inadequate culture methods. After
endodontic treatment is also rampant. Again, modern the development of anaerobic culture techniques, how-
antianxiety drugs have been developed, displacing the ever, investigators were able to show nearly 100% infec-
sedatives, hypnotics, and soporifics often misused to con- tion of necrotic pulps (Table 18-1).3
trol anxiety in the past. In the present-day pharmacy, One of the primary goals of endodontic treatment is
drugs are available that work directly against anxiety to eliminate a hospitable place for microorganisms to
without many of the side effects, making dental treat- grow. Dbridement of the canal soft tissues and debris
ment easier for the patient and the practitioner alike, should be as thorough as possible. The space should be
enabling more patients to receive optimal dental care. totally obturated to isolate any remaining tissue from
The up-to-date dentist, and the endodontist in par- the body and to close off that path for oral bacteria to
ticular, must be prepared to handle any pharmacologic reach beyond the apex. Sterile technique should be
exigency. One must know not only actions and reac- used throughout the procedures to avoid introducing
tions to drugs but also indications and contraindica- any new microbes into the patient. Attention to proper
tions, as well as side effects, toxicity, half-life, and any technique also protects the entire staff from receiving
interaction the newly prescribed drug may have with pathogens from the patient.
other drugs the patient may be taking. Periapically, bacteria do not usually hold the
This chapter is meant to be a specific overview of advantage, and infection is less likely. Without a
drugs vital to endodontics. For in-depth details about doubt, situations occur where chronic infections per-
any of these drugs, the reader is referred to a pharma- sist in the periapex following root canal therapy.
cology text, the Physicians Desk Reference (PDR), or the Tronstad believes that most periapical granulomas are
U.S. Pharmacopeia (USP). infected.4 Gatti et al. showed bacterial presence in
chronic asymptomatic, enlarging, periapical radiolu-
INFECTION CONTROL cent lesions discovered at postendodontic recall.5
The overwhelming importance of microorganisms to
endodontics was highlighted in 1965 by the classic
experiment of Kakehashi et al.1 They found that expos- Table 18-1 Bacterial Pathways to the Pulp
ing the pulps of germ-free rats to the oral environment
Caries
caused no pulpal destruction beyond the operative
Periodontal disease
wound. In control animals, however, with normal oral
Fractures
flora, the same pulpal exposure resulted in pulpal
Dentinal tubules not covered by cementum
necrosis and periradicular abscess, just as it does in the
Anachoresis
endodontic patient.
They used the highly accurate deoxyribonucleic acid Table 18-3 Common Examples of Oral Penicillins
(DNA) probe technique. Ratner et al. have shown and Cephalosporins
anaerobes within bone lesions from old extraction
Penicillins
sites to be related to trigeminal neuralgia.6 Others dis- Penicillin V 500 mg qid
covered similar-appearing lesions around failing root Ampicillin 500 mg qid
canals at surgery.7 Amoxicillin 500 mg tid/qid
ANTIBIOTICS Augmentin 500 mg tid/qid
Cephalosporins
Antibacterial agents, commonly called antibiotics, are
First generation
very useful because they kill bacteria without damage
Cephalexin (Keflex) 500 mg qid
to the host. These drugs attack cell structure and meta-
Cefadroxil (Duricef) 500 mg qid
bolic paths unique to bacteria and not shared with
Second generation
human cells. Systemic antibiotics are used frequently in
Cefuroxime (Ceftin) 250 or 500 mg bid
the practice of medicine and dentistry. Some say they Cefaclor (Ceclor) 500 mg tid
are overused. Although this is probably true, it is also Third generation
difficult to tell when an infection might spread to cause Cefixime (Suprax) 400 mg daily
life-threatening problems, such as cavernous sinus
thrombosis, Ludwigs angina, danger-space swelling Dosages may vary with the specific situation.
reaching into the mediastinum, brain abscess, or endo-
carditis, all of which have developed as sequelae of root Fast-killing antibacterial agents are often called
canal therapy. It is probably wise to use systemic bactericidal, meaning that they are observed to kill
antibiotics when there is a reasonable possibility of quickly in the laboratory. Penicillins, cephalosporins,
microorganisms beyond the root canal. The immuno- and metronidazole are the bactericidal antibiotics
logically compromised patient should also be consid- commonly used against endodontic pathogens. The
ered an indication for antibiotic therapy, regardless of first two kill by integrating into and weakening a
the condition of the canal. newly made cell wall, whereas the latter impedes DNA
This discussion of antibiotics will not include par- manufacture. Both require actively growing organ-
enteral-use drugs or drugs used rarely in dental isms to be effective, so antibiotics that fight bacteria
patients, which need monitoring by a physician by slowing their protein synthesis (bacteriostatic
because of potential side effects. The dental practition- antibiotics) are generally not given along with these
er should be acutely aware of signs of infection not bactericidal drugs.
responding to oral antibiotic therapy and be speedy in
referring such patients to an infection specialist. Allergies
make it stable in the presence of -lactamase. The combi- them a subgroup of the penicillin family. Their
nation is called Augmentin. improvement has seen three major improvements in
Bacterial resistance may also be developed by muta- their ability to kill stubborn infections, so the drugs are
tion of the DNA molecule or can be acquired from classed as first, second, and third generation. First-gen-
other bacteria by DNA transfer, even from one species eration cephalosporins have the most value in dentistry
of bacteria to another. In addition to enzymatic since they kill most oral pathogens and should be con-
destruction of antibiotic molecules, as with -lacta- sidered for use in most infections. Second- and third-
mase, bacteria sometimes become resistant by not generation cephalosporins are used for refractory infec-
allowing an antibiotic to pass through the cell wall or tions, probably after laboratory results of a culture. Oral
cell membrane. Another resistance situation occurs cephalosporins lag behind parenteral ones in the devel-
when the bacteria can pump the antibiotic molecule opment process. One must give consideration to hospi-
overboard faster than it can enter. talization and intravenous antibiotic therapy if the seri-
Bacteria generally pass on their resistance genes to ously ill patient does not respond to oral drug therapy.
their offspring. Fortunately, if not used, this DNA will
sometimes not be passed on to future generations. Metronidazole
Although recent laboratory research is developing new Metronidazole (Flagyl) is also considered a bactericidal
antibiotics awaiting approval, these new drugs will drug because of its fast killing time. It attacks the bacte-
probably fall prey to new forms of bacterial resistance. rias DNA and works against obligate anaerobes but not
It behooves the professions to limit antibiotic therapy against facultative bacteria or aerobes. Metronidazole is
to those situations in which the patient will likely ben- often used in combination with another antibiotic, usu-
efit from treatment and not expose the wonder drugs ally amoxicillin, to combat the stomach ulcercausing
to bacterias resistance-making mechanisms. Helicobacter pylori. This combination of two fast-killing
Replantation of avulsed teeth, on the other hand, drugs also helps in severe dental infections. Periodontists
calls for systemic antibiotic therapy in conjunction find metronidazole helpful in destroying deep-pocket
with endodontic treatment for best results. Success, as anaerobes, bacteria that obviously infect the root canal in
measured by the degree of inflammatory root resorp- many instances. Metronidazole shares properties with
tion, was judged to be superior by Hammarstrom and disulfiram (Antabuse), a drug used to help alcoholics
coworkers when permanent incisors of monkeys were avoid alcohol by inducing violent vomiting. So patients
replanted under controlled conditions.8 taking metronidazole should be cautioned about not
using alcohol for the time they are taking the drug plus 1
Penicillins day following to allow the drug to be eliminated from
Penicillins have a short half-life, limited to about 1 hour. their system.
It is important to tell patients the need to be prompt in The half-life of metronidazole is in the 8- to 10-hour
taking their pills. Because they are excreted unchanged range. Side effects include an unpleasant, metallic taste
by the kidneys, they are very useful in treating urinary and brown discoloration of the urine, effects that are
tract infections, where they accumulate in powerful dose related.
killing levels. In patients with compromised kidney
function, reducing the dosage is appropriate. The dentist Fluoroquinolones
should discuss with the patients physician, if the indi- Fluoroquinolones interfere with DNA replication, clas-
vidual patient is undergoing kidney dialysis, and tailor sifying them as bactericidal. However, they are not
the penicillin or cephalosporin dosage according to the effective against microbes commonly seen in endodon-
dialysis schedule. tic infections. Their use in dentistry should probably be
Penicillins are unique in their lack of toxicity. That limited to cases in which culture and sensitivity results
is, if the patient is not allergic, there is no maximum prove their indication.
dose of penicillin and no side effects from overdosage.
Amoxicillin is generally considered the penicillin of Macrolides
first choice because of its somewhat better absorption Erythromycins kill bacteria by slowing the manufac-
from the gut. ture of bacterial protein but do not alter the rate of
human protein synthesis. Because of their large mole-
Cephalosporins cule, erythromycins are also called macrolides (Table
Cephalosporins have been developed over the last three 18-4). These drugs kill about the same bacteria as peni-
decades. Because of the -lactam ring, many consider cillins, albeit by different means, so they are the drug of
choice for patients allergic to penicillins. They are ifestations such as cardiac arrhythmias. It should be
notorious for causing stomach cramps because they noted that clarithromycin (Biaxin) is metabolized by
increase gut motility, and many patients who are sus- both the liver and the kidney, perhaps causing less bot-
ceptible to this phenomenon report that they are aller- tleneck in the liver. Caution is warranted, however, in
gic. True allergy exists, so the doctor must use judg- patients with either kidney or liver compromise because
ment based on a thorough history before deciding to the half-life of the drug is prolonged.
use this type of drug. The macrolides kill many gram- The half-life of most erythromycins is in the range of
positive bacteria but have a limited spectrum for gram- 1 to 2 hours, whereas the newer ones remain active
negative bacteria. At one time, dentists were particular- longer. Clarithromycins half-life is 6 hours, and
ly fond of using erythromycins because of the lack of azithromycin has a remarkable 40-hour half-life.
risk of life-threatening anaphylactic allergic reaction, There are a few case reports of severe muscle weakness
but recently discovered serious interactions with other in patients taking lovastatin (Mevacor) for cholesterol
drugs have lessened their popularity. The wider-spec- reduction who have been given a macrolide. Although
trum new macrolides, azithromycin and clar- this relationship is not clearly defined, it would be wise to
ithromycin, are more useful for dental infections if the select another antibiotic when the patient is taking this
practitioner is cautious of potential drug interactions. type of cholesterol-lowering drug (Table 18-5).9
The newer macrolides also develop higher tissue con-
centrations. Clindamycin
These recently discovered problems with other Clindamycin (Cleocin) is often indicated in endodon-
drugs are because they share the same metabolic path- tic infections. It is rapidly and completely absorbed and
way. The first discovered problem drugs were the large- has a good spectrum of killing oral pathogens, includ-
molecule antihistamines terfenadine (Seldane) and ing many anaerobes. It was, however, the first antibiot-
astemizole (Hismanal). Seldane is no longer available ic to be associated with causing pseudomembranous
in the United States because of fatal reactions with colitis, a life-threatening condition in which large
other drugs metabolized similarly. Mid-size molecule patches of gut slough epithelium because of toxins
antihistamines, fexofenadine (Allegra), loratidine from overgrowth of the nonsusceptible organism
(Claritin), and cetirizine (Zyrtec), do not seem to be a Clostridium difficile. This serious condition requires
problem. hospital management with intravenous fluids and
Cisapride (Propulsid), given to increase gut motil- antibiotics specific for the causative Clostridium.
ity and treat esophageal reflux, has been associated with Patients being treated with clindamycin who experi-
fatal heart arrhythmias when these patients have con- ence diarrhea or another gut problem should immedi-
currently taken macrolide antibiotics. The elimination ately be referred to their physician for evaluation.
half-life of cisapride is 8 to 10 hours. This serious con- Other broad-spectrum antibiotics have been associated
traindication should encourage all practitioners to with this phenomenon as well.
update the patients medical history frequently. The average half-life of clindamycin is about 3
Another serious potential problem lies with the bron- hours. Although clindamycin does not cross the blood-
chodilator theophylline, used for asthmatic patients, brain barrier, it does penetrate into abscesses and other
often at doses near the toxic level, in whom there is real areas of poor circulation rather well.
potential for severe complications with the macrolides.
Both of these drugs share the same metabolic pathway. Tetracyclines
Too many molecules of the drug overwhelm the pathway There is one standout among the tetracycline family of
and high systemic levels result, giving rise to toxic man- antibiotics: doxycycline (Vibramycin). It has a long
Table 18-4 Macrolide Antibiotics Table 18-5 Other Oral Antibiotics Commonly Used
in Dentistry
Erythromycin base 250500 mg qid
Erythromycin stearate 250500 mg qid Metronidazole (Flagyl) 250500 mg qid
Erythromycin estolate (Ilosone) 250500 mg qid Clindamycin (Cleocin) 150300 mg qid
Clarithromycin (Biaxin) 250500 mg bid Doxycycline (Vibramycin) 100 mg bid
Azithromycin (Zithromax) 500 mg bid 1 d, then
one daily
half-life and is least affected by heavy metal ions such as hormones in birth control pills. This side effect
calcium, so the patient does not have to avoid dairy remains unproved.
products and antacids. Tetracyclines kill the broadest Change in gut flora is definitely associated with
spectrum of microbes of all antibiotics. They have increased levels of digitalis preparations, commonly
recently found a place in periodontal infection fighting used in heart conditions. Dangerously high levels can
and should be included in the endodontists armamen- occur, and such patients need a consultation with their
tarium since periodontal pathogens frequently invade physician. Diminution of gut bacteria by antibiotics
the root canal and periapical tissues. also changes output of vitamin K, needed in blood clot-
Recall that all tetracyclines cause staining of developing ting, so patients on anticoagulant therapy should also
teeth as they bind to calcium during formation of teeth be cautioned to consult with their physician.
and bones. This means that their use should be avoided in Endodontists are in a unique position among den-
children and pregnant women if at all possible. tists because of the preponderance of anaerobes in the
A rare side effect is phototoxicity, where exposure to conditions treated. A good specimen for culturing can
the sun causes severe sunburn or rash. Patients should often be obtained by needle aspiration from an abscess
be cautioned to avoid sun exposure while taking tetra- that has not yet drained. The specimen should be
cyclines unless they are sure that they are not suscepti- placed in an oxygen-free container available from a
ble to this side effect. Half-lives of most tetracyclines local hospital laboratory. A culture can be a big advan-
are about 10 hours, whereas doxycyclines half-life is 16 tage when a patient does not respond to the first antibi-
hours, allowing twice-daily dosing. otic. The practitioner can telephone the laboratory and
quickly learn which drug to use next.
Sulfa Drugs Hospitalization for administration of antibiotics
Sulfa drugs, often combined with trimethoprim to intravenously should be considered when the patient is
reduce resistance problems, are frequently used for uri- not responding to oral antibiotics. Many new-genera-
nary tract infections. Sulfa drugs predate penicillin by a tion antibiotics are available only parenterally, and the
decade but were quickly replaced by the more dramat- continuous dosage of intravenous administration gives
ic bacteria killer. Sulfa drugs cannot kill rapidly because higher blood levels without the complication of oral-
they merely compete with a precursor in the bioforma- dosing variables such as half-life and patient compli-
tion of folic acid, which many bacteria cannot obtain ance. The results of culture and sensitivity tests can
from other sources and must manufacture for them- greatly aid in selection of the appropriate drug when
selves. Their kill speed is dependent on the amount of hospitalization is warranted.
natural precursors in the environment. In other words, Use of corticosteroids to reduce inflammation
sulfa drugs are the slowest of the slow, the poorest of remains popular among some practitioners. Reducing
bacteriostatic antibiotics. Their main plus is that they inflammation relieves symptoms but also reduces the
accumulate in the bladder. They are not generally use- efficiency of white blood cells, which are crucial to infec-
ful in dentistry. tion fighting. Sometimes prophylactic antibiotics are
prescribed as a precaution when corticosteroids are used.
Caveats
In prescribing antibiotics, it seems warranted to con- Antibiotic Prophylaxis
tinue therapy for 2 or 3 days after symptoms have Dentists should all be aware of the need, before dental
resolved. In theory, if viable bacteria are present when treatment, to premedicate with antibiotics patients
antibiotic levels drop below the killing threshold, who have certain heart ailments. Systemic diseases
mutations can occur more readily. Patients are often compromising the immune system also call for consid-
not conscientious about continuing medications once eration of prophylactic antibiotics in situations for
their symptoms resolve. A reminder telephone call to which they might not otherwise be indicated. The goal
check on their condition and reinforce the need to fin- of antibiotic prophylaxis is to prevent clinical infection
ish their prescription is well advised. by helping destroy small numbers of bacteria present
Females of childbearing age should be told that per- before or introduced during treatment. Oral bacteria
haps antibiotics will interfere with the effectiveness of released during dental treatment clearly can cause
oral contraceptives. If they need antibiotics, other heart and artificial joint infections. Oral streptococci,
means of birth control should be used through the next in particular, have been indicted as causative organisms
cycle. Some researchers believe that antibiotic-induced for seeding heart and implanted joints, causing mor-
reduction in the gut flora causes malabsorption of the bidity or even death.
Oral streptococci are weak pathogens known as viri- ond category. These act at the site of injury to reduce
dans strep. They are -hemolytic, meaning that they pain-invoking prostaglandins that are made within the
cannot totally metabolize blood on a culture plate. They damaged cell. Although not classed as a pain reliever,
can, however, store energy molecules intra- and extracel- corticosteroids relieve pain by this mechanism as well
lularly. These external stores are long-chain polysaccha- but have many side effects. Finally, acetaminophen
rides, also known as the sticky substance of dental (Tylenol) is the third type. Acetaminophen acts pri-
plaque. These long chains become seriously pathogenic marily on the brain to relieve pain.
when viridans colonies form on heart valves, trapping Modern endodontic therapy does not elicit much
blood cells and fibrin and thereby reducing heart effi- pain. However, many patients associate it with pain,
ciency by hindering closure of the valves. Furthermore, partly because pain was a hallmark of early endodontic
portions of the sticky vegetations, as they are called, treatment and partly because the media often portray
break off and lodge in small vessels at distant sites, caus- endodontics in this light. Just as a placebo will alleviate
ing ischemia with possibly disastrous consequences. symptoms if the brain is convinced it will work, the
For many years, the American Heart Association has patient who anticipates pain usually needs higher doses
made recommendations for antibiotic therapy to kill or stronger types of drug for relief. For patients antici-
bacteria released into the bloodstream when certain pating pain, a prescription drug is often the only thing
dental procedures are performed. These recommenda- that will be effective (Table 18-7). Surgical pain, post-
tions have been updated as new knowledge became operative pain, and where the patient has significant
available. The most recent was in 1997.10 Following preoperative pain usually warrant narcotics.
these suggestions, the American Academy of Narcotics can cause addiction, with characteristics
Orthopaedic Surgeons and the American Dental unique from other types of addiction. Both physical
Association collaborated to make further recommen- and psychological addiction occur. Patients may pres-
dations for patients with artificial joints.11 ent a story of drug allergies, leaving the practitioner
There was an addendum to these recommendations no choice but to prescribe narcotics. Be aware of this
in late 1997 about patients taking the diet pills com- type of patient and make certain that there is a real
monly known as fen-phen because of a propensity of medical need for narcotics; otherwise, you may be feed-
these drugs to cause heart valve defects.12 The drugs ing someones addiction or helping a drug pusher
fenfluramine (Pondamin) or dexfenfluramine obtain his stock.
(Redux), with or without phentermine (Adipex or Narcotics are central nervous system (CNS) depres-
Fastin), have been associated with an alarming devel- sants and work synergistically with all other CNS
opment of permanent, serious heart valve defects, pri- depressants. The most commonly available CNS
marily in women. Patients who have taken these diet depressant, alcohol, is contraindicated with narcotics.
pills, even for a short time, should be premedicated Narcotics reduce reaction times, and narcotized
unless an echocardiogram has proven that their heart is patients must not drive or operate machinery. Usually,
properly functioning. Over-the-counter diet pills have narcotics are combined with acetaminophen or aspirin
not been associated with any heart problem. or an NSAID to make them more effective without
It is important to note that all of these recommen- excessive narcotic side effects.
dations are guidelines, not mandates, and that modifi- Propoxyphene was originally introduced as a non-
cations may be needed for some situations. narcotic; however, it is now known as a rather weak
Consultation with the patients physician is always in narcotic. It works for many patients, perhaps in part
order if any doubt exists. because its characteristic, dizziness, makes the patient
Bender et al. pointed out the value of destroying feel that it must be helping with the pain. Darvon is
intraoral bacteria with an antiseptic prior to invasive available plain or with aspirin; with acetaminophen, it
procedures.13 Heimdahl and coworkers also demon- is called Darvocet-N.
strated bacteremia from endodontic procedures con- Codeine has been a standard drug in dentistry for
fined to the canal (Table 18-6).14 many years because it is usually powerful enough to
control dental pain. It is irritating to the stomach in
PAIN CONTROL high doses, however, so addicts are seldom appeased.
There are three categories of pain control medications. Unfortunately, many patients with legitimate pain are
Narcotics are the most powerful. They have three types troubled with this gastrointestinal upset.
of receptors in the brain. Aspirin and the nonsteroidal Hydrocodone (Vicodin), a development of the
anti-inflammatory drugs (NSAIDS) make up the sec- 1980s, is less irritating to the gut and has become very
Table 18-6 Summary of Guidelines for Antibiotic Prophylaxis for Heart and Artificial Joint Patients
Medical History
Heart patients
Any artificial valve Isolated atrial-septal defect
Previous endocarditis Coronary artery bypass graft
Pulmonary shunt Surgical repair of septal defect
Most congenital defects Functional murmur
Rheumatic heart disease Rheumatic fever without valve damage
Hypertrophic cardiomegaly Pacemaker
MVP with regurgitation MVP without regurgitation
Fen-phen diet pill history Fen-phen with a normal echocardiogram
Artificial joint patients
Immunocompromised/immunosuppressed
Inflammatory arthropathies
Rheumatoid arthritis
Systemic lupus erythematosus
Disease, drug, or radiation immunosuppression
Other patients
Insulin-dependent diabetes mellitus
Artificial joint within past 2 y
History of failed artificial joint
Malnutrition
Hemophilia
Dental Treatment
All dosages are given 1 hour preoperatively, with no following doses, unless otherwise indicated.
Macrolides are NOT recommended for prophylaxis of artificial joints
MVP = mitral valve prolapse; fen-phen = fenfluramine-phentermine.
Table 18-7 Pain Control Medications Taken Orally receptor, decreases respiration, and increases intracra-
nial pressure. It also causes dizziness, nausea, and con-
Narcotics
stipation and potentiates other CNS depressants.
Propoxyphene: Darvon (plain or with aspirin),
Unlike other opiates, tramadol is not fully reversed by
Darvocet-N (with acetaminophen)
naloxone (Narcan). Further, it inhibits reuptake of
Codeine: Phenaphen, Empirin (with aspirin), Tylenol
serotonin and norepinephrine, a monoamine; hence,
with Codeine
concomitant administration with monoamine oxidase
Hydrocodone: Vicodin, Lorcet, Lortab, Vicoprofen
inhibitor drugs is not recommended. Tramadol is well
(with ibuprofen)
absorbed orally, and the usual adult dose is 50 to 100 mg
Oxycodone: Percodan (with aspirin), Percocet, or
four times a day.
Tylox (with acetaminophen)
Meperidine: Demerol
Aspirin has been a standard drug for dental pain for
Morphine: Oramorph, others
many years and is still useful. It, however, prolongs
bleeding, and for this reason is a poor presurgical drug.
Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDS) The anticoagulant effect comes from interference with
Aspirin platelet formation. Aspirin irreversibly binds the
Ibuprofen: Motrin, Advil, Nuprin enzyme cyclooxygenase, key to the pathway from injury-
Etodolac: Lodine induced arachidonic acid, that is released from the mem-
Fenoprofen: Nalfon branes of all cells, leading to production of inflamma-
Naproxen: Aleve, Naprosyn, Anaprox tion and pain-causing prostaglandins. Platelets in circu-
Cyclooxygenase 2 inhibitor NSAIDS lation do not have enough protein synthesis reserves to
Celecoxib: Celebrex replace the bound cyclooxygenase and are thus unable to
Rofecoxib: Vioxx participate in clotting for the remainder of their cell
lifearound 11 days. Many patients are on routine, low-
Acetaminophen dosage aspirin therapy for prophylaxis against stroke or
Tylenol heart attack. Prior to endodontic surgery, consultation
with their physician may be in order.
For patients with stomach problems, consider the
use of coated aspirin, such as Ecotrin. The coating will
popular in dentistry. It is less powerful than its cousin not dissolve until reaching the alkaline conditions of
oxycodone, which is notoriously famous among drug the small intestine. This means that drug action will be
addicts for its euphoria. Percodan is oxycodone with delayed for the usual 2-hour stomach transit time.
aspirin, whereas Percocet and Tylox are oxycodone Alternatively, aspirin buffered with chemicals such as
with acetaminophen. Occasionally, patients will experi- magnesium, calcium, or aluminum compounds to
ence sufficient pain from endodontic procedures to decrease stomach complaints (Bufferin, Ascripton)
require high-level narcotics, such as oxycodone or can be considered for sensitive patients.
meperidine (Demerol). A stronger drug effect carries Nonsteroidal anti-inflammatory drugs (Motrin/
more frequent side effects, including constipation, Advil) do not cause interruption of platelet synthesis
euphoria, sedation, impaired coordination, and pupil- for nearly as long because their binding to cyclooxyge-
lary constriction. Morphine is available orally as nase is reversible. Bleeding profiles return to normal
Oramorph and by other trade names. Like most other shortly after NSAIDS are metabolized. Nonsteroidal
drugs given orally, because of rapid liver metabolism anti-inflammatory drugs were found to be superior to
following oral dosing, a larger dose is required than is 60 mg of codeine for pain relief in many pain studies.
typical of the parenteral dose. Morphine pills are avail- They have also been injected locally into the jaws, with
able in 10, 15, 30, 60, and 100 mg amounts. The higher good result in diminishing postoperative pain associat-
levels are reserved for terminal cancer patients. For ed with pulpectomy. 15
severe dental pain, such as when the bony cortical Both NSAIDS and aspirin cause stomach upset and
plates confine infection pressure, necessitating very can be ulcerogenic. The deleterious stomach (and kid-
strong drug therapy, morphine remains a viable choice ney) effects of aspirin and NSAIDS are caused by
for the astute practitioner. action on one of the cyclooxygenase enzymes,
Tramadol (Ultram) is a new, potent, synthetic pain cyclooxygenase 1 (COX-1), which seems to predomi-
reliever that has similarities and differences with the nate in the stomach and kidney. Arachidonic acid is
classic opiates. Similarly, it binds with the mu opioid released by damaged cell membranes. Two forms of the
enzyme cyclooxygenase transform the arachidonic acid recent study, nearly 30% of laypersons surveyed said
into prostaglandins, which have diverse actions. The that they were nervous about going to the dentist.
action we are interested in moderating is the one that Over half of this group said that they would go to the
produces inflammation and pain, which is catalyzed by dentist more often if given a sedative drug.19 It is a
the cyclooxygenase 2 (COX-2) pathway. common observation in practice that patients arrive
Celecoxib (Celebrex) and rofecoxib (Vioxx) have fearful. To worsen matters, epinephrine, commonly
the unique capability of limiting prostaglandin synthe- administered to retain local anesthetic in the area of
sis from the pathways controlled by COX 2. This spares injection, increases anxiety. Caffeine can also release
the side effects of prostaglandin inhibition of the COX- endogenous catecholamines and aggravate the fear
1 pathway that can harm the gut and/or kidneys.16 The reaction. Perhaps it would be wise to recommend
other NSAIDS have action on both pathways. avoiding caffeine and to reduce epinephrine if feasible
These new COX-2 inhibitor NSAIDS were introduced for anxious patients. Smoking also prolongs caffeines
with great promise of exclusive targeting of the pain- half-life of 5 to 7 hours.
inducing prostaglandin production. Unfortunately, clin- For many years, anxious patients were treated by
ical use has shown them to have serious gut and kidney verbally belittling their fear or by inappropriate drug
side effects in some patients. The incidence of these side therapy. Narcotics and/or barbiturates and other seda-
effects is lower than with classic NSAIDS. As with all new tives were used without much success. They were not
drugs, the practitioner should carefully weigh the poten- working on the fear itself. Benzodiazepines are now
tial benefits with the higher costs always related to devel- available that act directly on the brain centers that con-
opment of new drugs, as well as the potential for yet trol fear. This class of drug not only relieves anxiety but
undiscovered side effects. is also an anticonvulsant, an amnestic, a sedative, and a
Acetaminophen (Tylenol) gives patients relief via its muscle relaxant.
action directly on an unknown site in the brain. It was The first of the benzodiazepines discovered was
discovered many years ago, and its cousin phenacetin diazepam (Valium). Its usefulness is limited by its
was popularized in the now unavailable APC formu- long half-life, approaching 60 hours. One reason for
lation of aspirin, phenacetin, and caffeine. Although it the long life span of the drug is that two of its metabo-
is effective against pain and fever, inflammation lites are pharmacologically active. By administering
remains unchanged by acetaminophen. Some practi- one of these metabolites or a similar drug with a short-
tioners alternate acetaminophen and aspirin every 2 er half-life, the duration of drug effect is lessened.
hours to enhance pain relief. Excedrin, Goodys Lorazepam (Ativan) is an example of using a
Headache Powder, and other preparations contain diazepam metabolite as the administered drug, with its
aspirin and acetaminophen. half-life in the 14-hour range. Triazolam (Halcion), a
Acetaminophen is metabolized by the liver and slightly different molecule, has a half-life of approxi-
should be used cautiously in patients with liver disease mately 3 hours and is popular for dental procedures.
or chronic alcohol use. Considerable controversy exists Any drug administered orally has considerable vari-
about use of acetaminophen in alcohol abusers with ation because of the first-pass effect, as drug-laden
compromised liver function. Most recent evidence sug- blood from the stomach and small intestine goes first
gests that a metabolite is the problem and that abrupt to the liver, where significant metabolism immediately
cessation of alcohol intake can lead to higher levels of reduces the drug level before it reaches its target.
the toxic metabolite than if some alcohol intake was Berthold and coworkers showed that slowly dissolving
continued.17 Obviously, it is best to avoid acetamino- a 0.25 mg tablet of triazolam intraorally gives higher
phen when liver capability is in question. blood plasma levels than swallowing the same amount
On the positive side, acetaminophen does not cause of drug, probably by allowing absorption through the
stomach irritation. Also interesting is the fact that oral mucosa that does not progress directly to the
research data show that acetaminophen is better for liver.20 Ehrich et al. also found oral 0.25 mg triazolam
elevation of the threshold for sharp pain, such as with superior to 5.0 mg diazepam for decreasing anxiety,
dental treatment, than other types of pain relievers.18 superior amnesia, and better patient perception of
drug effectiveness. 21
ANXIETY REDUCTION Oral drug administration should occur in the office
As mentioned earlier, many patients view endodontic to allow monitoring and should occur about 1 hour
therapy as a painful process and avoid treatment, to prior to treatment. As with all CNS depressants, one
the detriment of their dental and general health. In a must consider lowering the dose when the patient is
concurrently taking another CNS depressant. Patients 8. Hammarstrom L, Blomlof L, Anderson L, Lindskog S.
must not be allowed to drive or operate machinery. Replantation of teeth and antibiotic treatment. Endod
Dent Traumatol 1996;2:51.
Anxious patients will gladly make arrangements for a
9. Corpier CL, et al. Rhabdomyolysis and renal injury with lovas-
driver to escort them home. tatin use. JAMA 1988;260:239.
An additional positive effect of the benzodiazepine 10. Dajani AS, et al. Prevention of bacterial endocarditis. JAMA
drugs is their amnesia. Patients frequently think that 1997;277:1794.
the treatment took significantly less time than it actu- 11. Advisory statement: antibiotic prophylaxis for dental patients
ally did and also have gaps in their recall of events dur- with total joint replacements. J Am Dent Assoc
1997;129:1004.
ing the procedure, probably from a direct drug effect 12. US Department of Health and Human Services Interim Public
on their brain. Obviously, it is necessary to have a sec- Health Recommendation. MMWR Morb Mortal Wkly Rep
ond person in the treatment room at all times. 1997;46:10616.
Although there are wide safety margins with dose, safe- 13. Bender IB, Naidorf IJ, Garvey GJ. Bacterial endocarditis: a con-
ty is further enhanced by the recent development of a sideration for the physician and dentist. J Am Dent Assoc
1984;109:415.
specific drug antagonist, flumazenil (Romazicon),
14. Heimdahl A, Hall G, Hedberg M, et al. Detection and quanti-
which is injected parenterally to offset adverse effects. tation by lysis-filtration of bacteremia after different oral
surgical procedures. J Clin Microbiol 1990;28:2205.
REFERENCES 15. Penniston SG, Hargreaves KM. Evaluation of periapical injec-
1. Kakehashi G, Stanley HR, Fitzgerald R. The effects of surgical tion of ketorolac for management of endodontic pain. J
exposures of dental pulps in germ-free and conventional Endod 1996;22:55.
laboratory rats. Oral Surg 1965;20:340. 16. Pennisi E. Building a better aspirin. Science 1998;280:1191.
2. Nair PNR. Apical periodontitis: a dynamic encounter between 17. Slattery JT, Nelson SD, Thummel KE. The complex interaction
root canal infection and host response. Periodontology between ethanol and acetaminophen. Clin Pharmacol Ther
1997;13:121. 1996;60:241.
3. Kantz WE, Henry CA. Isolation and classification of anaerobic 18. Carnes PL, Cook B, Eleazer PD, Scheetz JP. Change in pain
bacteria from intact pulp chambers of non-vital teeth in threshold to sharp pain by meperidine, naproxen, and acet-
man. Arch Oral Biol 1974;19:91. aminophen as determined by electric pulp testing. Anesth
4. Tronstad L.Extraradicular endodontic infections. Endodont Prog 1998;45:139.
Dent Traumatol 1987;3:86. 19. Dionne RA, et al. Assessing the need for anesthesia and seda-
5. Gatti J, Skobe Z, Dubeck JM, et al. Bacterial DNA in periapical tion in the general population. J Am Dent Assoc
lesions using two surgical techniques [abstract]. J Dent Res 1998;129:167.
1997;76:58. 20. Berthold CE, Corey SE, Dionne RA. Triazolam drug levels fol-
6. Ratner EJ, et al. Jawbone cavities and trigeminal and atypical lowing sublingually and orally administered premedication
facial neuralgias. Oral Surg 1979;48:3. [abstract]. J Dent Res 1997;76:114.
7. McMahon RE, Adams W, Spolnick KJ. Diagnostic anesthesia 21. Ehrich DG, Lundgren JP, Dionne RA, et al. Comparison of tri-
for referred trigeminal pain: part 1. Compend Contin Educ azolam, diazepam, and placebo as outpatient oral premed-
Dent 1992;13:980. ication for endodontic patients. J Endod 1997;23:181.
Chapter 19
RESTORATION OF
ENDODONTICALLY TREATED TEETH
Charles J. Goodacre and Joseph Y. K. Kan
Various methods of restoring pulpless teeth have been adapted to the inside of an all-ceramic crown and also
reported for more than 200 years. In 1747, Pierre into the root canal space. Moisture would swell the
Fauchard described the process by which roots of max- wood and retain the pivot in place.2 Surprisingly,
illary anterior teeth were used for the restoration of Prothero reported removing two central incisor crowns
single teeth and the replacement of multiple teeth with wooden pivots that had been successfully used for
(Figure 19-1).1 Posts were fabricated of gold or silver 18 years.2 Subsequently, pivot crowns were fabricated
and held in the root canal space with a heat-softened using wood/metal combinations, and then more
adhesive called mastic.1,2 The longevity of restora- durable all-metal pivots were used. Metal pivot reten-
tions made using this technique was attested to by tion was achieved by various means such as threads,
Fauchard: Teeth and artificial dentures, fastened with
posts and gold wire, hold better than all others. They
sometimes last fifteen to twenty years and even more
without displacement. Common thread and silk, used
ordinarily to attach all kinds of teeth or artificial pieces,
do not last long.1
In Fauchards day, replacement crowns were made
from bone, ivory, animal teeth, and sound natural
tooth crowns. Gradually, the use of these natural sub-
stances declined, to be slowly replaced by porcelain. A
pivot (what is today termed a post) was used to retain
the artificial porcelain crown into a root canal, and the
crown-post combination was termed a pivot crown.
Porcelain pivot crowns were described in the early
1800s by a well-known dentist of Paris, Dubois de
Chemant.2 Pivoting (posting) of artificial crowns to
natural roots became the most common method of
replacing artificial teeth and was reported as the best
that can be employed by Chapin Harris in The Dental
Art in 1839.3
Early pivot crowns in the United States used sea-
soned wood (white hickory) pivots.4 The pivot was Figure 19-1 Early attempts to restore single or multiple units. A,
Pivot tooth consisting of crown, post, and assembled unit. B, Six-
unit anterior bridge pivoted in lateral incisors with canines can-
tilevered. Crowns were fashioned from diversity of materials.
*The authors are indebted to Drs. Kenneth C. Trabert, Joseph P. Human, hippopotamus, sea horse, and ox teeth were used, as well as
Cooney, Angelo A. Caputo, and Jon P. Standlee of the University of ivory and oxen leg bones. Posts were usually made from precious
California School of Dentistry, Los Angeles, who contributed so metals and fastened to crown and root using a heated sticky mas-
generously the many fine illustrations, photographs, and laborato- tic prepared by gum, lac, turpentine, and white coral powder.
ry findings found in this chapter. (Reproduced with permission from Fauchard P.1)
pins, surface roughening, and split designs that provid- SHOULD CROWNS BE PLACED ON
ed mechanical spring retention.2 ENDODONTICALLY TREATED TEETH?
Unfortunately, adequate cements were not available A retrospective study of 1,273 teeth endodontically
to these early practitionerscements that would have treated 1 to 25 years previously compared the clinical
enhanced post retention and decreased abrasion of the success of anterior and posterior teeth.6 Endo-
root caused by movement of metal posts within the dontically treated teeth with restorations that encom-
canal. One of the best representations of a pivoted passed the tooth (onlays, partial- or complete-coverage
tooth appears in Dental Physiology and Surgery, written metal crowns, and metal ceramic crowns) were com-
by Sir John Tomes in 1849 (Figure 19-2).5 Tomess post pared with endodontically treated teeth with no coro-
length and diameter conform closely to todays princi- nal coverage restorations. It was determined that coro-
ples in fabricating posts. nal coverage crowns did not significantly improve the
Endodontic therapy by these dental pioneers success of endodontically treated anterior teeth. This
embraced only minimal efforts to clean, shape, and finding supports the use of a conservative restoration
obturate the canal. Frequent use of the wood posts in such as an etched resin in the access opening of other-
empty canals led to repeated episodes of swelling and wise intact or minimally restored anterior teeth.
pain. Wood posts, however, did allow the escape of the Crowns are indicated only on endodontically treated
so-called morbid humors. A groove in the post or anterior teeth when they are structurally weakened by
root canal provided a pathway for continual suppura- the presence of large and/or multiple coronal restora-
tion from the periradicular tissues.1 tions or they require significant form/color changes
Although many of the restorative techniques used that cannot be effected by bleaching, resin bonding, or
today had their inception in the 1800s and early 1900s, porcelain laminate veneers. Scurria et al. collected data
proper endodontic treatment was neglected until years from 30 insurance carriers in 45 states regarding the
later. Today, both the endodontic and prosthodontic procedures 654 general dentists performed on
aspects of treatment have advanced significantly, new endodontically treated teeth.7 The data indicated that
materials and techniques have been developed, and a 67% of endodontically treated anterior teeth were
substantial body of scientific knowledge is available on restored without a crown, supporting the concept that
which to base clinical treatment decisions. many anterior teeth are being satisfactorily restored
The purpose of this chapter is to answer questions without the use of a crown.
frequently asked when dental treatment involves pulp- When endodontically treated posterior teeth (with
less teeth and to describe the techniques commonly and without coronal coverage restorations) were com-
employed when restoring endodontically treated teeth. pared, a significant increase in the clinical success was
Whenever possible, the answers and discussion will be noted when cuspal coverage crowns were placed on
supported by scientific evidence. maxillary and mandibular molars and premolars.6
Therefore, restorations that encompass the cusps
should be used on posterior teeth that have interdigita-
tion with opposing teeth and thereby receive occlusal
forces that push the cusps apart. The previously dis-
cussed insurance data indicated that 37 to 40% of pos-
terior pulpless teeth were restored by practitioners
without a crown, a method of treatment not supported
by the long-term clinical prognosis of posterior
endodontically treated teeth that do not have cusp-
encompassing crowns.7 There are, however, certain
posterior teeth (not as high as 40%) that do not have
substantive occlusal interdigitation or have an occlusal
form that precludes interdigitation of a nature that
attempts to separate the cusps (such as mandibular
first premolars with small, poorly developed lingual
cusps). When these teeth are intact or minimally
Figure 19-2 Principles used today in selecting post length and restored, they would be reasonable candidates for
diameter were understood and taught by early practitioners during restoration of only the access opening without use of a
mid-1800s. Reproduced with permission from Tomes J.5 coronal coverage crown.
Multiple clinical studies of fixed partial dentures, required to fracture dentin may be less when teeth are
many with long spans and cantilevers, have determined endodontically treated because of potentially weaker
that endodontically treated abutments failed more collagen intermolecular cross-links.19
often than abutment teeth with vital pulps owing to
tooth fracture,812 supporting the greater fragility of Conclusions
endodontically treated teeth and the need to design Restorations that encompass the cusps of endodonti-
restorations that reduce the potential for both crown cally treated posterior teeth have been found to
and root fractures when extensive fixed prosthodontic increase the clinical longevity of these teeth. Therefore,
treatment is required. crowns should be placed on endodontically treated
Gutmann reviewed the literature and presented an posterior teeth that have occlusal interdigitation with
overview of several articles that identify what happens opposing teeth of the nature that places expansive
when teeth are endodontically treated.13 These articles forces on the cusps. Since crowns do not enhance the
provide background information important to an clinical success of anterior endodontically treated
understanding of why coronal coverage crowns help teeth, their use on relatively sound teeth should be lim-
prevent fractures of posterior teeth. Endodontically ited to situations in which esthetic and functional
treated dog teeth were found to have 9% less moisture requirements cannot be adequately achieved by other,
than vital teeth.14 Also, with aging, greater amounts of more conservative restorations (Figure 19-3).
peritubular dentin are formed, which decreases the
amount of organic materials that may contain mois- WITH PULPLESS TEETH, DO POSTS IMPROVE
ture. It has been shown that endodontic procedures LONG-TERM CLINICAL PROGNOSIS OR
reduce tooth stiffness by 5%, attributed primarily to ENHANCE STRENGTH?
the access opening.15 Laboratory Data
Tidmarsh described the structure of an intact tooth Virtually all laboratory studies have shown that place-
that permits deformation when loaded occlusally and ment of a post and core either fails to increase the frac-
elastic recovery after removal of the load.16 The direct ture resistance of extracted endodontically treated
relationship between tooth structure removed during teeth or decreases the fracture resistance of the tooth
tooth preparation and tooth deformation under load of when a force is applied via a mechanical testing
mastication has been described.17 Dentin from machine.2025 Lovdahl and Nicholls found that
endodontically treated teeth has been shown to exhibit endodontically treated maxillary central incisors were
significantly lower shear strength and toughness than stronger when the natural crown was intact, except for
vital dentin.18 Rivera et al. stated that the effort the access opening, than when they were restored with
cast posts and cores or pin-retained amalgams.20 Lu
found that posts placed in intact endodontically treat-
ed central incisors did not lead to an increase in the
force required to fracture the tooth or in the position
and angulation of the fracture line.21 McDonald et al.
found no difference in the impact fracture resistance
of mandibular incisors with or without posts.22
Eshelman and Sayegh25a reported similar results when
posts were placed in extracted dog lateral incisors.
Guzy and Nicholls determined that there was no sig-
nificant reinforcement achieved by cementing a post
into an endodontically treated tooth that was intact
except for the access opening.23 Leary et al. measured
the root deflection of endodontically treated teeth
before and after posts of various lengths were cement-
Figure 19-3 Incisal view of an intact central incisor that required ed into prepared root canals.24 They found no signifi-
endodontic treatment owing to trauma. Placement of a bonded cant differences in strength between the teeth with or
resin restoration in the access opening is the only treatment
required since crowns do not enhance the longevity of anterior
without a post. Trope et al. determined that preparing
endodontically treated teeth. A crown would only be used when a post space weakened endodontically treated teeth
esthetic and functional needs cannot be achieved through more compared with ones in which only an access opening
conservative treatments. was made but no post space.25
Table 19-1 Clinical Failure Rate of Posts and Cores WHAT ARE THE MOST COMMON TYPES OF
POST AND CORE FAILURES?
Lead Author Study Length % Clinical Failure
Seven studies indicate that post loosening is the most
Turner, 1982*33 5y 12 (6 of 52)
common cause of post and core failure (Figure 19-
Sorenson, 198435 125 y 9 (36 of 420) 4).33,34,36,37,39,43,44 Turner reported on 100 failures of
Bergman, 1989*36 5y 9 (9 of 96) post-retained crowns and indicated that post loosening
Weine, 1991*38 10 y or more 7 (9 of 138) was the most common type of failure.43 Of the 100
failures, 59 were caused by post loosening. The next
Hatzikyriakos, 1992*34 3y 11 (17 of 154)
most common occurrences were 42 apical abscesses
Mentink, 1993*39 110 y 8 (39 of 516) followed by 19 carious lesions. There were 10 root frac-
(4.8 mean) tures and 6 post fractures. In another article by Turner,
Wallerstedt, 1984*40 40 y 14 (8 of 56) he reported the findings of a 5-year retrospective study
(7.8 mean) of 52 post-retained crowns.33 Six posts had come loose,
Torbjrner, 199537 169 mo 9 (72 of 788) which was the most common failure. Lewis and Smith
presented data regarding 67 post and core failures after
Mean values 6 yr 9 (196 of 2,220) 4 years.44 Forty-seven of the failures (70%) resulted
*Studies used to calculate mean study length. from posts loosening, 8 from root fractures, 7 from
Calculation made by averaging numeric data from all studies. caries, and 4 from bent or fractured posts. Bergman et
al. found 8 failures in 96 posts after 5 years.36 Six posts
had come loose, and 2 roots fractured. Hatzikyriakos et
posts and cores) from posts and cores placed by den- al. reported on 154 posts and cores after 3 years.34 Five
tal students.40 posts had come loose, 5 crowns had come loose, 4 roots
Kaplan-Meier survival statistics (percent survival fractured, and caries caused 3 failures. Mentink et al.
over certain time periods) were presented or could be identified 30 post loosenings and 9 tooth fractures
calculated from the data in seven studies (Table when evaluating 516 posts and cores over a 1- to 10-
19-2).41 The survival rates ranged from a high of 99% year time period (4.8 years mean study length).39
after 10 years or more of follow-up to a 78% survival Torbjrner et al. reported on the frequency of 3 techni-
rate after a mean time of 5.2 years. The percent failure cal failures (loss of retention, root fracture, and post
per year has also been calculated and ranged from fracture).37 They did not report biologic failures. Loss
1.56%/year36 to 4.3%/year.42 of retention was the most frequent post failure,
accounting for 45 of the 72 post and core failures
Conclusions
(62.5%). Root fracture was the second most common
Posts and cores had an average absolute rate of failure failure cause, followed by post fracture (Figure 19-5).
of 9% (7 to 14% range) when the data from eight stud-
ies were combined (average study length of 6 years).
Table 19-3 Clinical Loss of Retention Associated with Posts and Cores
% of Posts Placed % of Failures
Lead Author Study Length That Loosened Post Form Owing To Loosening
Table 19-4 Clinical Tooth Fractures Associated with Posts and Cores
% of Teeth Restored
with Posts That % of Failures Owing
Lead Author Study Length Fractured Post Form(s) Studied To Fracture
rations are more retentive than cemented, smooth- with cast tapered posts. Hatzikyriakos et al. studied
sided parallel posts. tapered threaded posts, parallel cemented posts, and
tapered cemented posts.34 The only posts that loosened
Clinical Data from the root were parallel cemented posts.
There is clinical support for these laboratory studies.
Torbjrner et al. reported significantly greater loss of Conclusions
retention with tapered posts (7%) compared with par- Tapered posts are the least retentive and threaded
allel posts (4%).37 Sorenson and Martinoff determined posts the most retentive in laboratory studies. Most of
that 4% of tapered posts failed by loss of retention, the clinical data support the laboratory findings.
whereas 1% of parallel posts failed in that manner.35
Turner indicated that tapered posts loosened clinically IS THERE A RELATIONSHIP BETWEEN
more frequently than parallel-sided posts.43 Lewis and POST FORM AND THE POTENTIAL FOR
Smith also found a higher loss of retention with ROOT FRACTURE?
smooth-walled tapered posts than parallel posts.44
Bergman et al.36 and Mentink et al.39 evaluated only Laboratory Data
tapered posts, and both studies reported that 6% of Using photoelastic stress analysis, Henry determined
tapered posts failed via loss of retention, values higher that threaded posts produced undesirable levels of
than those recorded by Torbjrner et al.37 and stress.47 Another study used strain gauges attached to
Sorenson and Martinoff35 for parallel posts. the root and compared four parallel-sided threaded
Contrasting results were reported by Weine et al.38 posts with one parallel-sided nonthreaded post.48 Two
They found no clinical failures from loss of retention of the threaded posts produced the highest strains,
whereas two other threaded posts caused strains com- prefabricated parallel posts and cast posts and cores.21
parable to the nonthreaded post. Standlee et al., using Assif et al. tested the resistance of extracted teeth to
photoelastic methods, indicated that tapered, threaded fracture when the teeth were restored with either paral-
posts were the worst stress producers.49 When three lel or tapered posts and complete crowns.62 No signifi-
types of threaded posts were compared in extracted cant differences were noted, and post design did not
teeth, Deutsch et al. found that tapered, threaded posts influence fracture resistance.
increased root fracture by 20 times that of the parallel In analyzing the stress distribution of posts, it was
threaded posts.50 noted that tapered posts generate the least cementation
Laboratory testing of split-threaded posts has pro- stress and should be considered for teeth that have thin
vided varying results, but more research groups have root walls, are nearly perforated, or have perforation
concluded that they do not reduce the stress associated repairs.54
with threaded posts. Thorsteinsson et al. determined
that split-threaded posts did not reduce stress concen- Clinical Data
tration during loading.51 In another study, split, thread- There are several clinical studies that provide data
ed posts were found to produce installation stresses related to the incidence of root fracture associated with
comparable to other threaded posts.52 Greater stress different post forms. Some of these studies provide a
concentrations than some other threaded posts were comparison of multiple post forms, whereas other
reported under simulated functional loading.5355 Rolf studies evaluated only one type of post. Combining all
et al. found that a split, threaded post produced compa- of the root fracture data for each post form from both
rable stress to one type of threaded post and less stress types of studies reveals some interesting trends (Table
than a third threaded post design.56 Ross et al. deter- 19-5). Five studies present data regarding root fractures
mined that a split-threaded post produced less root and threaded posts,30,35,40,45,46 four regarding fracture
strain than two other threaded posts and comparable associated with parallel-sided cemented posts,30,35,37,46
strain to a third threaded post and a nonthreaded post.48 and seven related to tapered, cemented posts.30,3539,46
Another research group concluded that the split, thread- If the total number of threaded posts evaluated in the
ed design reduced the stresses caused during cementa- five studies is divided into the total number of fractures
tion compared with a rigid, threaded post design.57 found with threaded posts, a percent value can be
Multiple photoelastic stress studies concluded that determined that represents the average incidence of
posts designed for cementation produced less stress tooth fracture associated with threaded posts in the five
than threaded posts.47,49,56 studies. The same data can be calculated for parallel
When parallel-sided cemented posts have been com- cemented and tapered cemented posts, permitting a
pared with tapered cemented posts, photoelastic stress comparison of the root fracture incidences associated
testing results have generally favored parallel-sided with these three post forms.
posts. Using this methodology, Henry found that par- Combining the five studies that reported data rela-
allel-sided posts distribute stress more evenly to the tive to threaded posts produced a mean fracture rate of
root.47 Finite-element analysis studies produced simi- 7% (11 fractures from 169 posts). The four clinical
lar results.58,59 Two additional photoelastic studies con- studies that contain fracture data from parallel-sided
cluded that parallel posts concentrate stress apically cemented posts produced a mean fracture incidence of
and tapered posts concentrate stress at the post-core 1% (9 fractures from 687 posts). From the seven stud-
junction.51,54 Also, using photoelastic testing, Assif et ies reporting root fracture with tapered posts, there is a
al. found that tapered posts showed equal stress distri- mean fracture rate of 3% (50 root fractures from 1,553
bution between the cementoenamel junction and the posts). These combined study data support the previ-
apex compared with parallel posts, which concentrated ously cited photoelastic laboratory stress tests, indicat-
the stress apically.60 ing that the greatest incidence of root fractures
When fracture patterns in extracted teeth were used occurred with threaded posts and that the lowest per-
to compare parallel and tapered posts, the evidence centage of root fracture was associated with parallel
favoring parallel posts is less favorable. Sorenson and cemented posts. In a meta-analysis of selected clinical
Engelman determined that tapered posts caused more studies, Creugers et al. calculated a 91% tooth survival
extensive fractures than parallel-sided posts, but the rate for cemented cast posts and cores and an 81% sur-
load required to create fracture was significantly high- vival rate for threaded posts with resin cores.41
er with tapered posts.61 Lu, also using extracted teeth, Although the combined data from all of the studies
found no difference in the fracture location between for each type of post revealed certain trends, analysis of
Threaded Posts (Lead Author) Parallel-Sided Posts (Lead Author) Tapered Posts (Lead Author)
individual studies (where multiple post forms were allel posts into the dental market).35,37 The mean time
compared in the same study) produced less conclusive since placement for each post form was not identified in
results. One study of threaded and cemented posts these studies. Also, both of these studies were based on
determined that teeth with threaded posts were lost reviews of patient records (rather than clinical exami-
more frequently than teeth with cast posts.29 In three nations) and depended on the accuracy of dental charts
other clinical comparisons of threaded and cemented in determining if and when posts failed, as well as the
posts, no tooth fracture differences were noted between cause of the failure. Another factor that affected the
threaded and cemented posts.30,34,46 In addition to the results of many of the referenced clinical studies was the
comparisons of threaded and cemented posts, four length of the posts. For instance, in Sorenson and
clinical studies provide data comparing the tooth frac- Martinoff s study, 44% of the tapered cemented posts
ture incidences associated with parallel-sided and had a length that was half (or less than half) the
tapered posts. In comparing parallel and tapered posts incisocervical/occlusocervical dimension of the crown
by reviewing dental charting records, a higher failure whereas only 4% of the parallel cemented posts were
rate was reported with tapered posts than parallel posts that short.35 Since short posts have been associated with
in two studies,35,37 and the failures were judged to be higher root stresses in laboratory studies, the difference
more severe with tapered posts. Two other clinical in post length may have affected their findings in which
studies determined that there were no differences tooth fractures occurred with 18 of 245 tapered posts
between tapered and parallel-sided posts.34,46 compared with no fractures with 170 parallel posts.
Hatzikyriakos et al. found no significant differences
between 47 parallel cemented posts and 44 tapered Conclusions
cemented posts after 3 years of service.34 Ross evaluat- When evaluating the relationship between post form
ed 86 teeth with posts and cores that had been restored and root fracture, laboratory tests generally indicate
at least 5 years previously.46 No fracture differences that all types of threaded posts produce the greatest
were found between 38 tapered cemented posts and 39 potential for root fracture. When comparing tapered
parallel cemented posts. and parallel cemented posts using photoelastic stress
Unfortunately, the total number of clinical studies analysis, the results generally favor the parallel cement-
that compared multiple post forms in the same study is ed posts. However, the evidence is mixed when the
limited. Also, several factors may have affected the find- comparison between tapered and parallel posts is based
ings of available studies. Two of the articles that con- on fracture patterns in extracted teeth created by apply-
tained a comparison of multiple post forms covered ing a force via a mechanical testing machine.
sufficiently long time periods (10 to 25 years) that the When evaluating the combined data from multiple
tapered cemented posts may have been in place for clinical studies, threaded posts generally produced the
much longer time periods than the parallel-sided highest root fracture incidence (7%) compared with
cemented posts (owing to the later introduction of par- tapered cemented posts (3%) and parallel cemented
posts (1%). Analysis of individual clinical studies as of the post with the maximum length available if 3 mm
opposed to the combined data produces less conclusive of gutta-percha were retained.33 Posts that came loose
results. Additional comparative clinical studies would used only 59% of the ideal length, and only 37% of the
be beneficial, including designs that have not yet been posts were longer than the proposed minimum length.
evaluated in comparative studies. Nine millimeters were proposed as the ideal length.
Sorensen and Martinoff determined that clinical
WHAT IS THE PROPER LENGTH FOR A POST? success was markedly improved when the post was
A wide range of recommendations have been made equal to or greater than the crown length.35 Johnson
regarding post length, which includes the following: (1) and Sakumura determined that posts that were three-
the post length should equal the incisocervical or quarters or more of the root length were up to 30%
occlusocervical dimension of the crown6370; (2) the more retentive than posts half of the root length or
post should be longer than the crown71; (3) the post equal to the crown length.86 Leary et al. indicated that
should be one and one-third the crown length72; (4) posts with a length at least three-quarters of the root
the post should be half the root length73,74; (5) the post offered the greatest rigidity and least root bending.87
should be two-thirds the root length7579; (6) the post These data indicate that post length would appro-
should be four-fifths the root length80; (7) the post priately be three-quarters that of root length. However,
should be terminated halfway between the crestal bone some interesting results occur when post length guide-
and root apex8183; and (8) the post should be as long lines of two-thirds to three-quarters the root length are
as possible without disturbing the apical seal.47 A applied to teeth with average, long, and short root
review of scientific data provides the basis for differen- lengths. It was determined that a post approaching this
tiating between these varied guidelines. recommended length range is not possible without
Although short posts have never been advocated, they compromising the apical seal by retaining less than
have frequently been observed during radiographic 5 mm of gutta-percha.88 When post length was half
examinations (Figure 19-6). Grieve and McAndrew that of the root, the apical seal was rarely compromised
found that only 34% of 327 posts were as long as the on average-length roots. However, when posts were
incisocervical length of the crown.84 In a clinical study of two-thirds the root length, many of the average- and
200 endodontically treated teeth, Ross determined that short-length roots would have less than the optimal
only 14% of posts were two-thirds or more of the root gutta-percha seal. Shillingburg et al. also indicated that
length and 49% of the posts were one-third or less of the making the post length equal the clinical crown length
root length.46 A radiographic study of 217 posts deter- can cause the post to encroach on the 4.0 mm safety
mined that only 5% of the posts were two-thirds to three- zone required for an apical seal.89
quarters the root length.85 In a retrospective clinical study Abou-Rass et al. proposed a post length guideline for
of 52 posts, Turner radiographically compared the length maxillary and mandibular molars based on the inci-
dence of lateral root perforations occurring when post
preparations were made in 150 extracted teeth.90 They
determined that molar posts should not be extended
more than 7 mm apical to the root canal orifice.
When teeth have diminished bone support, stresses
increase dramatically and are concentrated in the
dentin near the post apex.91 A recent finite-element
model study established a relationship between post
length and alveolar bone level.92 To minimize stress in
the dentin and in the post, the post should extend more
than 4 mm apical to the bone.
Conclusions
Reasonable clinical guidelines for length include the fol-
lowing: (1) Make the post approximately three-quarters
the length of the root when treating long-rooted teeth;
(2) when average root length is encountered, then post
Figure 19-6 Radiograph showing a very short post in the distal root length is dictated by retaining 5 mm of apical gutta-per-
of the first molar that has loosened and caused prosthesis failure. cha and extending the post to the gutta-percha (Figure
Conclusions lary first molar, about 1.0 mm; and for the remaining
Laboratory studies relating retention to post diameter teeth, about 0.8 to 0.9 mm.
have produced mixed results, whereas a more definitive Shillingburg et al. measured 700 root dimensions to
relationship has been established between root fracture determine the post diameters that would minimize the
and large-diameter posts (Figure 19-9). risk of perforation.89 Also based on not exceeding one-
third the mesiodistal root width, they recommended
WHAT IS THE RELATIONSHIP BETWEEN the following post diameters (see Table 19-6):
POST DIAMETER AND THE POTENTIAL mandibular incisors, 0.7 mm; maxillary central incisors
FOR ROOT PERFORATIONS? or other large roots, 1.7 mm, which was the maximal
In a literature review of guidelines associated with post recommended dimension; post tip diameter, at least 1.5
diameter, Lloyd and Palik indicated that there are three mm less than root diameter at that point; and post
distinct philosophies of post space preparation.107 One diameter at the middle of the root length, 2.0 mm less
group advocated the narrowest diameter for fabrication than the root diameter.
of a certain post length (the conservationists). Another Post spaces were prepared in 150 extracted maxillary
group proposed a space with a diameter that does not and mandibular molars using different instrument
exceed one-third the root diameter (the proportionists). diameters, and the resulting incidences of perforations
The third group advised leaving at least 1 mm of sound were recorded.90 The authors determined that the mesial
dentin surrounding the entire post (the preservationists). roots of mandibular molars and the buccal roots of
Based on the proportional concept of one-third the maxillary molars should not be used for posts owing to
root diameter, three articles measured the root diame- the higher risk of perforation on the furcation side of the
ters of extracted teeth and proposed post diameters root. For the principal roots (mandibular distal and
that would not exceed that proportion.89,90,108 Tilk et maxillary palatal), they determined that posts should not
al. examined 1,500 roots.108 They measured the nar- be extended more than 7 mm into the root canal (apical
rowest mesiodistal dimension at the apical, middle, and to the pulp chamber) owing to the risk of perforation.
cervical one-thirds of the teeth except the palatal root Regarding instrument size, they concluded that post
of the maxillary first molar, which was measured faci- preparations can be safely completed using a No. 2 Peeso
olingually. Based on a 95% confidence level that post instrument, but perforations are more likely when the
width would not exceed one-third the apical width of larger No. 3 and 4 Peeso (Dentsply/Maillefer North
the root, they proposed the following post widths America; Tulsa, Okla.; Moyco/Union Broach; York, Pa.)
(Table 19-6): small teeth such as mandibular incisors, instruments were used.
about 0.6 to 0.7 mm; large-diameter roots such as max- Raiden et al. evaluated several instrument diameters
illary central incisors and the palatal root of the maxil- (0.7, 0.9, 1.1, 1.3, 1.5, and 1.7 mm) to determine which
A B
Figure 19-9 Excessive post diameters. A, A large-diameter post placed in the palatal root of the maxillary molar. B, A large-diameter thread-
ed post caused fracture of the maxillary second premolar. The radiographic appearance of the bone is typical of a fractured roota teardrop-
shaped lesion with a diffuse border.
one(s) would preserve at least 1 mm of root wall thick- found no difference between immediate preparation of a
ness following post preparation in maxillary first pre- post space and preparation 1 week later when 4 mm of
molars.109 They determined that instrument diameter gutta-percha were retained.110 Zmener found no differ-
must be small (0.7 mm or less) for maxillary first pre- ence in dye penetration between gutta-percha removal
molars with single canals because the mesial and distal after 5 minutes and 48 hours.111 Two sealers were tested,
developmental root depressions restrict the amount of and 4 mm of gutta-percha were retained apically. When
available tooth structure in the centrally located single lateral condensation of gutta-percha was used, Madison
root canal. However, when there are dual canals, the and Zakariasen found no difference in the dye penetra-
instrument can be as large as 1.1 mm because the tion between immediate removal and 48-hour
canals are located buccally and lingually into thicker removal.94 Using the chlorpercha filling technique,
areas of the roots.
Conclusions
Instruments used to prepare posts should be related in
size to root dimensions to avoid excessive post diameters
that lead to root perforation (Figure 19-10). Safe instru-
ment diameters to use are 0.6 to 0.7 mm for small teeth
such as mandibular incisors and 1 to 1.2 mm for large-
diameter roots such as the maxillary central incisor.
Molar posts longer than 7 mm have an increased chance
of perforations and therefore should be avoided even
when using instruments of an appropriate diameter.
CAN GUTTA-PERCHA BE REMOVED
IMMEDIATELY AFTER ENDODONTIC
TREATMENT AND A POST SPACE PREPARED?
Several studies indicate that there is no difference in the Figure 19-10 The excessive post diameter in the maxillary second
leakage of the root canal filling material when the post premolar created a perforation in the mesial root concavity. Note
space is prepared immediately after completing the distinct border and round form of the radiolucent lesion, char-
endodontic therapy.94,110112 Bourgeois and Lemon acteristics indicative of a root perforation.
Schnell found no difference between immediate removal CAN A PORTION OF A SILVER POINT BE
of gutta-percha and no removal of gutta-percha.112 By REMOVED AND STILL MAINTAIN THE
contrast, Dickey et al. found significantly greater leakage APICAL SEAL?
with immediate gutta-percha removal.113 In one study, all of the specimens leaked when 1 mm of
Kwan and Harrington tested the effect of immediate a 5-mm-long silver point was removed using a round
gutta-percha removal using both warm and rotary bur.111 Neagley found that removal of the filling materi-
instruments.114 There was no significant difference al coronal to the silver point with a Peeso reamer caused
between the controls and immediate removal using no leakage.95 However, when all of the filling material
warm pluggers and files. Compared to the controls, there and 1 mm of the silver point were removed, complete
was significantly less leakage with immediate removal of dye penetration occurred in eight of nine specimens.
gutta-percha when using Gates-Glidden (Dentsply/
Maillefer North America; Tulsa, Okla.; Moyco/Union Conclusions
Broach; York, Pa.) drills. The removal of a portion of a silver point during post
Karapanou et al. compared immediate and delayed preparation causes apical leakage.
removal of two sealers (a zinc oxideeugenol sealer and
a resin sealer).115 No difference between immediate DOES THE USE OF A CERVICAL FERRULE
and delayed removal was noted with the resin sealer, (CIRCUMFERENTIAL BAND OF METAL) THAT
but delayed removal of the zinc oxideeugenol sealer ENGAGES TOOTH STRUCTURE HELP PREVENT
produced significantly greater leakage. TOOTH FRACTURE?
Portell et al. found that delayed gutta-percha Survey data indicate the percentage of respondents
removal (after 2 weeks) caused significantly more leak- who felt that a ferrule increased a tooths resistance to
age than immediate removal when only 3 mm of gutta- fracture.32 Fifty-six percent of general dentists, 67% of
percha were retained apically.96 Fan et al. found more prosthodontists, and 73% of board-certified prostho-
leakage from delayed removal of gutta-percha.116 dontists felt that core ferrules increased a tooths frac-
ture resistance. To investigate this concept, several
Conclusions
research studies have been performed. Some of the
Adequately condensed gutta-percha can be safely studies indicate that ferrules are beneficial, whereas
removed immediately after endodontic treatment. others found no increase in fracture resistance.
The results appear indecisive until three differ-
WHAT INSTRUMENTS REMOVE GUTTA-PERCHA
ences between study designs are analyzed. First, some
WITHOUT DISTURBING THE APICAL SEAL?
of the studies tested ferrules that were part of a cast
Multiple studies have determined that there is no differ- metal core (core ferrules),120124 whereas other stud-
ence in leakage between removing gutta-percha with hot ies evaluated the effectiveness of ferrules created by
instruments and removing it with rotary instru- the overlying crown engaging tooth structure.125128
ments.93,97,117 Suchina and Ludington117 and Mattison et One study evaluated both core and crown ferrules.129
al.97 found no difference between hot instrument Second, there were differences in the form of the fer-
removal and removal with Gates-Glidden burs. Camp rule and therefore the manner by which the metal
and Todd found no difference between Peeso reamers, engaged tooth structure (beveled sloping surface ver-
Gates-Glidden burs, and hot instruments.93 Hiltner et al. sus extension over relatively parallel prepared tooth
compared warm plugger removal with two types of structure). Third, there were variations in the
rotary instruments (GPX burs; Brassler, Savannah, amount of tooth structure encompassed by the fer-
Georgia, and Peeso reamers).118 There were no signifi- rules. Table 19-7 provides a comparison of the stud-
cant differences in dye leakage between any of the groups. ies and the effectiveness of the various core and
Contrasting results were found by Haddix et al.119 They crown ferrules.
measured significantly less leakage when the gutta-percha The data generally indicate that ferrules formed as
was removed with a heated plugger than when either a part of the core are less effective than ferrules created
GPX instrument or Gates-Glidden drills were used. when the overlying crown engages tooth structure. In
four of the six core ferrule studies, they were found to
Conclusions be ineffective.121,122,124,129 Also, in one of the two stud-
Both rotary instruments and hot hand instruments can ies in which the core ferrule was effective, the ferrule
safely be used to remove adequately condensed gutta- form was a 2 mm parallel extension of the core over
percha when 5 mm are retained apically. tooth structure120 as opposed to a bevel. In the other
Barkhordar, 1989 2 mm parallel extension of core Yes Extracted teeth/angular lingual force applied
over the tooth to p and c (no overlying crown)
Sorensen, 1990 1 mm wide 60-degree bevel at No Extracted teeth/angular lingual force applied
the tooth-core junction to p and c (with overlying crown)
Tjan, 1985 60-degree bevel at the No Extracted teeth/angular lingual force applied
tooth-core junction to p and c (no overlying crown)
Loney, 1990 1.5 mm parallel extension of No Photoelastic teeth/angular lingual force
core over the tooth applied to p and c (no overlying crown)
Hemmings, 1991 45-degree bevel Yes Extracted teeth/torsional force applied to
p and c (no overlying crown)
Saupe, 1996 2 mm parallel extension of core No Extracted teeth/angular lingual force applied
over thin dentin wall to p and c (no overlying crown)
(0.50.75 mm thick)
Sorensen, 1990 130-degree sloping finish line No Extracted teeth/p and c with crown
12 mm of tooth grasped by crown Yes Extracted teeth/p and c with crown
Libman, 1995 0.51 mm of prepared tooth No Extracted teeth/p and c with crown/cyclic
grasped by crown loading
1.52 mm of prepared tooth Yes Extracted teeth/p and c with crown/cyclic
grasped by crown loading
Milot, 1992 1 mm wide 60-degree bevel Yes Plastic analogies of teeth/p and c with
grasped by crown crowns
Isidor, 1999 1.25 mm of prepared tooth Yes Bovine teeth/cyclic angular load/p and c
grasped by crown with crown
2.5 mm of prepared tooth Yes, but more Bovine teeth/cyclic angular load/p & c
grasped by crown effective than with crown
1.25 mm
Hoag, 1982 12 mm of prepared tooth Yes Extracted teeth/p and c with crown
grasped by crown
study in which core ferrules were found to be effec- tapered end when they were covered by a crown that
tive,123 a torsional force was used as opposed to an grasped 2 mm of tooth structure.62
angular lingual force. The data also support the concept that ferrules that
In the crown ferrule studies, most of the ferrules grasp larger amounts of tooth structure are more effec-
effectively increased a tooths resistance to fracture. tive than those that engage only a small amount of
Only when the crown ferrule was of minimal dimen- tooth structure. In both the core and crown ferrule
sion125 or a sloping form129 was it found to be ineffec- studies, the tooths resistance to fracture was increased
tive. In support of these studies, Rosen and Partida- when a substantive amount of tooth structure was
Rivera found that a 2 mm cast gold collar (not part of engaged (2 mm in the core ferrule studies and 1 to 2
the post and core) was very effective in preventing root mm in the crown ferrule studies). Libman and Nicholls
fracture when a tapered screw post was intentionally found the 0.5 to 1.0 mm crown ferrule to be ineffec-
threaded into roots so as to induce fracture.130 Assif et tive,125 whereas a 1.5 to 2.0 mm crown ferrule was
al. found no difference in the tooth fracture patterns of effective. Isidor et al. determined that increasing crown
parallel posts, tapered posts, and parallel posts with a ferrule length significantly increased the number of
Conclusions
Differences of opinion exist regarding the effectiveness Figure 19-11 Types of ferrules. A, Tooth prepared for a post and
of ferrules in preventing tooth fracture. Ferrules have core. B, A post and core has been cemented into the tooth. The
been tested when they are part of the core and also when arrows note how the core has created a ferrule around the tooth
(core ferrule). C, A metal ceramic crown has been cemented over
the ferrule is created by the overlying crown-engaging
the core. The arrows show how the crown encompasses the tooth
tooth structure. Most of the data indicate that a ferrule cervically, establishing a crown ferrule.
created by the crown-encompassing tooth structure is
more effective than a ferrule that is part of the post and
core (Figure 19-11). Ferrule effectiveness is enhanced by
grasping larger amounts of tooth structure. The the primary roots (palatal root of maxillary molars and
amount of tooth structure engaged by the overlying distal roots of mandibular molars) and should not be
crown appears to be more important than the length of extended more than 7 mm apical to the origin of the
the post in increasing a tooths resistance to fracture. root canal in the base of the pulp chamber. Extension
Ferrules are more effective when the crown encompass- beyond this length can lead to root perforation or only
es relatively parallel prepared tooth structure than very thin areas of remaining tooth structure.
when it engages beveled/sloping tooth surfaces. Post Diameter
POST AND CORE PLACEMENT TECHNIQUES A frequently used and clinically appropriate guideline
Pretreatment Data Review for post diameter is to not exceed one-third the root
diameter. It has been determined that when a root
When it has been determined that a post and core is canal is prepared for a post and the diameter is
required to properly retain a definitive single crown or increased beyond one-third of the root diameter, the
fixed partial denture, the following characteristics should tooth becomes exponentially weaker. Each millimeter
be determined prior to beginning the clinical procedures of increase (beyond one-third the root diameter) caus-
associated with fabrication of a post and core: es a sixfold increase in the potential for root fracture.50
Based on measuring the root dimensions of 1,500 teeth
1. Post length (125 of each tooth) and using the guideline that the
2. Post diameter post should be one-third the root diameter, optimal
3. Anatomic/structural limitations post diameter measurements have been determined to
4. Type of post and core that will be used (prefabricat- be about 0.6 mm for mandibular incisors and 1.0 mm
ed post and restorative material core or anatomical- for maxillary central incisors, maxillary and mandibu-
ly customized cast post and core) lar canines, and the palatal root of the maxillary first
5. Root selection in multirooted teeth molar.108 The recommended post diameter for the
6. Type of definitive restoration being placed and its other teeth was 0.8 mm.108 Another study of 700 teeth
effect on core form and tooth reduction depths. recommended that post diameter should range from
0.7 mm for mandibular incisors to a maximum of 1.7
Post Length mm for maxillary central incisors.89
Since 5 mm of gutta-percha should be retained apical-
ly to ensure a good seal (as measured radiographically), Anatomic/Structural Limitations
posts should be extended to that length in all teeth The practitioner who completed the endodontic treat-
except molars. With molars, posts should be placed in ment is ideally suited to identify characteristics of the
pulp chamber, the anatomy of the root canal(s), and Root Curvature
completed endodontic filling that should be reviewed When root curvature is present, post length must be lim-
before placing a post and core. These characteristics ited to preserve remaining dentin, thereby helping to
include the presence and extent of dentinal craze lines, prevent root fracture or perforation. Root curvature
identification of teeth for which further root prepara- occurs most frequently in the apical 5 mm of the root.
tion (beyond that needed to complete endodontic Therefore, if 5 mm of gutta-percha are retained apically,
instrumentation) will result in less than 1 mm of curved portions of the root are usually avoided. As dis-
remaining dentin or a post diameter greater than one- cussed previously under post length, molar posts should
third the root diameter area, information regarding not exceed 7 mm in the primary roots because of the
areas in which the remaining tooth structure is thin, and potential for perforation owing to root curvature and
the point at which significant root curvature begins. the presence of developmental root depressions. Molar
roots are frequently curved, and the post should termi-
Craze Lines
nate at the point where substantive curvature begins.
Craze lines in dentin are areas of weakness where fur-
ther crack propagation may result in root fracture and Type of Post and Core
tooth loss. The patient should be informed of their Posts or dowels can be generally classified as
presence with appropriate chart documentation of cement/bonded posts or threaded posts. Cemented
crack location. It is prudent to avoid post placement, if posts depend on their close proximity to prepared
possible, in favor of a restorative material core. If a post dentin walls and the cementing medium. Examples are
is required, it should passively fit the canal, and the custom-cast posts and cores (Figure 19-12) and a vari-
definitive restoration should entirely encompass the ety of prefabricated designs (Figure 19-13). The pre-
cracked area, whenever possible, by forming a ferrule. fabricated designs include parallel-sided metal posts,
such as the Para-Post (Coltene/Whaledent, Mahwah,
Dentin Thickness After Endodontic Treatment New Jersey) (Figure 19-14) or different types of thread-
Following normal and appropriate endodontic instru- ed posts. Threaded posts depend primarily on engaging
mentation, teeth can possess less than 1 mm of dentin, the tootheither through threads formed in the
indicating that there should be no further root prepa- dentin as the post is screwed into the root or through
ration for the post. When these teeth are encountered, threads previously tapped into the dentin (eg, the
it is best to fabricate a post that fits into the existing Kurer post; Marie Reiko, Inc, Reno, Nevada). Examples
morphologic form and diameter rather than addition- of threaded posts include the Kurer post (Figure 19-
ally preparing the root to accept a prefabricated type of 15), the Dentatus (Dentatus USA, New York, New
post. This characteristic is one of the primary indica- York) post, and the Flexi-Post (Essential Dental, South
tions for use of a custom cast post and core. One study Hackensack, New Jersey) (Figure 19-16).
determined that canines (maxillary and mandibular), Recently, posts made of carbon fiber (C-Post, Aesthetic
maxillary central and lateral incisors, and the palatal Post, and Light Post, Bisco, Inc, Schaumburg, Illinois),
root of maxillary first molars possessed more than 1 ceramic materials (Cerapost, Brasseler, Savannah,
mm of dentin after endodontic cleaning and shap- Georgia; Cosmopost, Ivoclar-Vivadent, Amherst, New
ing.131 All other teeth had roots with less than 1 mm of York), and fiber-reinforced polymers (Ribbond, Ribbond,
remaining dentin following endodontic treatment. Inc, Seattle, Washington; Fibrekor Post System,
With the goal of preserving 1 mm of remaining dentin Jeneric/Pentron, Wallingsford, Connecticut) have been
lateral to posts, it has been determined that single- introduced. Carbon fiber posts are made of unidirection-
canal maxillary first premolars should have posts that al carbon fibers embedded in an epoxy matrix.133138
are 0.7 mm in diameter or less.109 Mandibular premo- Esthetic versions of this post have a quartz exterior that
lars with oval- or ribbon-shaped canals should not be makes the post tooth colored. Ceramic posts are made
subjected to any preparation of the root canal for a from zirconium dioxide.139142 Fiber-reinforced posts are
post since this will result in less than 1 mm of made of a woven polyethylene fiber ribbon that is coated
dentin.132 Preparation of the mesial root canals in with a dentin bonding agent and packed into the canal,
mandibular molars and the buccal root canals in max- where it is then light polymerized in position.143
illary molars can result in perforation or only thin Research indicates that carbon fiber posts possess
areas of remaining dentin. Based on measurements of adequate rigidity,134 are not prone to produce tooth
residual dentin thickness, it is recommended that fracture,135,136,138 and have been shown to be clinically
posts not be placed in these roots if possible. successful.137 It is reported that carbon fiber posts can
B C
A B
Figure 19-15 Kurer posts. A, Standard anchor. B, Crown saver. Figure 19-16 Flexi-post. Note the split in the apical portion of
the post that permits some flexion to occur during placement.
be removed from the tooth. Ceramic posts have very than a No. 2 Peeso instrument, which is 1.0 mm in
high flexual strengths and are very hard.139,141 When diameter). When 7 mm long posts were placed in the
polyethylene fiber-reinforced posts were compared mesial root of mandibular molars, 20 of the 75 tested
with metal posts in the laboratory, the fiber-reinforced teeth had only a thin layer of remaining dentin or were
posts reduced the incidence of vertical root fracture.143 perforated.90
The authors prefer to use posts designed for cemen-
tation whenever possible. However, when post retention Type of Definitive Restoration
is a critical success factor and available root length is It is important to know the type of single crown or
limited, threaded designs are appropriate and necessary. retainer (all-metal, all-ceramic, metal ceramic) that will
For teeth with large and/or round roots with sub- be used as the definitive restoration for each endodon-
stantial remaining root thickness after endodontic tically treated tooth that requires a post and core. This
treatment is completed, either a prefabricated post or knowledge permits the tooth to be reduced in accor-
custom cast post can be used. If root preparation dance with the reduction depths and form recom-
required to accommodate a prefabricated (round) post mended for each type of crown/retainer.
form will reduce dentin thickness to less than a mil-
TECHNICAL PROCEDURES
limeter, then a custom-cast post becomes the safest
type of post. Coronal Tooth Preparation
Post and core fabrication can often best be done after
Root Selection for Multirooted Teeth
the coronal tooth preparation has been completed
When posts and cores are needed in molars, posts are (Figure 19-17). The amount of tooth structure that
best placed in roots that have the greatest dentin thick- needs to be removed is related to the type of crown to
ness and the smallest developmental root depressions. be used, and that, in turn, determines the extent of core
The most appropriate roots (the primary roots) in fabrication. For instance, if some of the remaining
maxillary molars are the palatal roots, and in mandibu- tooth structure is very thin after the coronal prepara-
lar molars, they are the distal roots. The buccal roots of tions, it is better to remove that part of dentin and
maxillary molars and the mesial root of mandibular replace it as part of the core.
molars should be avoided if at all possible. If these
roots must be used in addition to the primary roots, Pulp Chamber Preparation
then the post length should be short (3 to 4 mm) and a The pulp chamber should be cleaned of any filling mate-
small-diameter instrument should be used (no larger rial prior to post space preparation (Figure 19-18). If a
A B
Figure 19-18 Pulp chamber preparation. A, Incisal view showing presence of provisional material sealing the coronal access. B, Rotary
instrument being used to remove provisional material.
Figure 19-19 Two different diameters of Gates-Glidden drills. Figure 19-20 Set of six Peeso reamers.
approximation to the root canal walls, then a cus- 8. When metal posts are used, they can be bent coro-
tom-cast post may be preferable. nally, if necessary, to align them within the core
5. Care must be taken not to remove more dentin at material (Figure 19-25). Post bending is done out-
the apical extent of the post space than is necessary. side the mouth with orthodontic pliers.
6. Radiographic confirmation is important to ensure 9. The post is cemented into the root canal using
proper seating and length of the post. resin bonding procedures (Figure 19-24, E).
7. The incisal/occlusal end of the post is shortened 10. If there is little or no remaining coronal tooth
(Figure 19-24, D) so that it does not interfere with structure to provide resistance to core rotation, an
the opposing occlusion, but it must provide sup- auxiliary threaded pin (TMS pins, minimum or
port and retention for the restorative core materi- regular; Coltene/Whaledent; Mahwah, N.J.) should
al (2 to 3 mm). be placed into the remaining tooth structure
(Figure 19-24, F).
A C
Figure 19-21 Root canal preparation. A, Rotary instrument being
used to prepare post space in a root canal. Note the rubber ring
around the instrument to identify the appropriate apical extension
of the post preparation. B, Post space preparation completed. C,
Periodontal probe being used to measure post space depth.
A B C
D E F G
Figure 19-22 Placement of parallel-walled Para-Post and composite resin core in an anterior tooth. A, Endodontic treatment completed
and initial crown preparation formed on remaining coronal tooth structure. B, Gutta-percha removed. C, Post space being formed using a
Peeso instrument. D, Post space being refined using a Para-Post drill. E, Trial placement of the post to verify adequate approximation to post
space without binding. F, The post has been shortened so that it does not interfere with occlusal closure and there will be space for fabrica-
tion of the crown. The post was cemented after shortening. G, The tooth has been etched and a bonded composite resin core formed and
then shaped using rotary instruments.
A B
C D
F
Figure 19-24 Placement of a carbon fiber post and composite
resin core. A, Post preparation completed to the desired form and
depth. Note the antirotation notch prepared into the dentin. B,
Carbon fiber post. C, Post placed into the canal to verify adequate
adaptation and passivity. D, Post being shortened using a diamond
instrument so that there is adequate occlusal clearance. E, The post
has been bonded into the root canal. F, Diagram showing place-
ment of a threaded pin because there was a lack of coronal tooth
structure to augment core retention. G, The composite resin core
has been bonded to the dentin. The tooth preparation can now be
completed by decreasing the total occlusal convergence, refining the
G finish line, and smoothing the surfaces.
A B
Figure 19-25 Coronal portion of posts are bent prior to cementa-
tion to place them more strategically within core. A, For contain-
ment inside preparation contour. B, For a more central location in Figure 19-26 Definitive tooth preparations. Composite resin core
core material. and remaining coronal tooth structure of a maxillary central inci-
sor have been prepared for a definitive all-ceramic crown.
11. Restorative material is then condensed around 2. Since most custom-cast posts and cores will possess a
the post or bonded to the post and remaining slightly tapered form, a flat area should be prepared
tooth structure. A slight excess of material is in the remaining coronal tooth structure if there is
placed, and this is removed during crown prepa- not one already present in existing morphology. This
ration (Figure 19-24, G). flat area (formed perpendicular to the long axis of
12. The definitive tooth preparation is then complet- the post) will serve as a positive stop during cemen-
ed (Figure 19-26), and an impression is made for tation of the post and during subsequent application
the crown. of occlusal forces, thereby helping to minimize any
tendency for the post to wedge against the tooth.
Prefabricated Threaded Post/ 3. The custom-cast post and core can either be made
Restorative Material Core indirectly on a cast obtained from an impression or
1. The root canal filling material is removed as fabricated from a pattern made directly on the
described. tooth. The indirect process is often the technique of
2. The canal is sequentially enlarged using the manu- choice for teeth with difficult or limited access.
facturers provided rotary instruments until the
desired diameter is achieved. Direct Procedure
3. The Kurer post system uses a root facer to prepare a 1. Select a plastic post that fits within the confines of
flat area on the coronal surface of the root against the post preparation without binding (Figure 19-
which the incorporated metal core can seat (Figure 30, A). Leave the post sufficiently long that it can be
19-27). Other threaded posts (such as the Flexi-post) easily grasped.
use a restorative material for the core (Figure 19-28) 2. Lightly lubricate the canal (using a water-soluble
and therefore do not need such an instrument. lubricant such as die lubricant helps ensure that all
4. Either the root is threaded using a hand tap (Kurer) lubricant can be subsequently removed, thereby
or the post is threaded into the canal (Flexi-post). not interfering with cement retention).
5. The core is formed by either reshaping the attached 3. Place notches on the side of a plastic post pattern if
metal core (Kurer) or building a restorative materi- the post is smooth and seat it to the depth of the
al core to the desired dimensions and then prepar- prepared canal.
ing it for the definitive crown. 4. Use the bead-brush technique to apply resin to the
prepared canal and the body of the plastic post.
Custom-Cast Post and Core
Seat the post into the full depth of the canal.
This procedure for making a custom-cast post and core 5. Do not allow the resin to completely harden within
is illustrated in Figure 19-29: the canal. Remove and reseat the post and attached
1. The root canal filling material is removed as resin several times while the resin is still in its rub-
described. It is not necessary or desirable to make bery stage so that the pattern does not inadvertent-
the post space round. ly become locked into the canal (Figure 19-30, B).
A B C D
E F G H I
Figure 19-27 Placement of a prefabricated, threaded Kurer post. A, Completed endodontic therapy. B, Gutta-percha removed. C, Initial
preparation of the root canal. D, Final diameter established, which also determines the size of the tap and the post that will be used. E,
Preparing countersink using a Root Facer instrument (Kurer, Kerr Corporation, Orange. California). F, Hand tap being used to create threads
in the root. G, Trail placement of a post to determine how much of the post must be shortened. H, Shortened post in place. I, The prefabri-
cated metal core has been prepared to a form that represents the shape of a prepared tooth and will provide appropriate space for fabrica-
tion of a crown.
Figure 19-28 Flexi-post has been 6. Remove the polymerized pattern and inspect the
placed into the root and a compos- resin for integrity and lack of voids. Reseat the post
ite resin material built around the
and test for adaptation and passivity.
post.
7. Add additional coronal resin to form the desired
dimensions of the core (Figure 19-30, C). Remove
and reseat the pattern as previously described to pre-
vent it from becoming locked into the coronal tooth
structure (Figure 19-30, D). A slight excess of core
resin is added (Figure 19-30, E) so that the hardened
core can be prepared with a high-speed diamond and
water spray to the desired form (Figure 19-30, F).
8. The core is then removed, invested, and cast.
9. The post and core are trial placed, adjusted, and
then cemented. The definitive tooth preparation
can then be completed.
10. A pattern can also be developed using wax rather
than resin.
Indirect Procedure
1. Nonaqueous elastomeric impression materials
make accurate impressions of the prepared root
canal, but some method of supporting the impres-
sion material prevents distortion/displacement of
the set material during removal from the mouth
and pouring of the cast.
Figure 19-29 Custom-cast post and core. A, Traumatically fractured central incisor after endodontic treatment and post space preparation.
B, Cast post and core seated in the tooth.
A B
C D
E F
Figure 19-30 Fabrication of a direct pattern for a custom-cast post and core. A, Plastic post selected that fits passively into the prepared
post space. B, Resin has been placed into the prepared root canal and the plastic post seated to the depth of the canal. Note that the plastic
post is being removed before the resin completely hardens to ensure that the resin post does not become locked into the prepared post space.
C, Additional unfilled resin is being applied using a bead-brush technique to build a core. D, The core buildup is being removed before it
completely hardens to again prevent the resin from becoming locked into position. E, Excess core material has been applied. F, Initial prepa-
ration of the resin core has been completed. The pattern can now be removed and cast and the final tooth preparation completed after the
post and core are cemented.
2. Several methods of support are available. A metal 14. After the post pattern has been fabricated, the wax
wire that returns to its original shape when slight- core is added (Figure 19-33, D) and shaped, and then
ly distorted is desirable. Safety pins (Figure 19-31, A) the pattern is cast in metal (see Figure 19-33, E).
and orthodontic wire have been used for this pur- 15. The cast post and core are then cemented in the
pose. Metal wire such as a paper clip can be bent tooth and the definitive tooth preparation com-
on impression removal and be permanently dis- pleted (Figure 19-33, F).
torted. Plastic posts are also used to support the
impression material (Figure 19-32, C). They can PREPARATION FOR OVERDENTURES
be flexed in slightly curved canals or if they con- An overdenture is a complete denture supported by
tact coronal tooth structure. Subsequent removal retained teeth and the residual alveolar ridge.144
of the post after the impression material sets Because the retained teeth are shortened, contoured,
allows straightening of the plastic post to occur, and altered to be covered, they need to be endodonti-
resulting in distortion. Only use plastic posts when cally treated (Figure 19-34).
they are totally passive and do not bind on any In 1969, Lord and Teel coined the term overden-
tooth structure. ture and described the combined endodontic-peri-
3. When a safety pin or orthodontic wire is selected as odontic-prosthodontic technique applied thereto.145
the means of supporting the impression material, As early as 1916, however, Prothero had referred to the
the coronal portion of the wire should be bent over use of root support, stating, Oftentimes two or three
to form a handle and to help retain it in the widely separated roots or teeth can be utilized for sup-
impression material (Figure 19-31, B). porting a denture.2 It should also be noted that much
4. Notch the wire and coat it with adhesive (see earlier, in 1789, George Washingtons first lower den-
Figure 19-31, B). ture, constructed of ivory by John Greenwood, was in
5. Fill the prepared canal with impression material part supported by a left mandibular premolar.146
using a slowly rotating lentulo spiral instrument Retaining roots in the alveolar process is based on the
(Dentsply Maillefer North America, Tulsa, Ok) proven observation that as long as the root remains, the
(Figure 19-31, C) accompanied by an up and down bone surrounding it remains (Figure 19-35). This over-
motion (Figure 19-31, D). comes the age-old prosthetic problem of ridge resorp-
6. Alternately, an anesthetic needle can be placed to tion. Ideally, then, retaining four teeth, two molars and
the depth of the post space (to serve as an air two caninesone each at the four divergent points of
escape channel) and impression material syringed an archshould provide good balance and long life to
down the canal (Figure 19-32, A and B). a full overdenture (Figure 19-36). Unfortunately,
7. Seat the wire or plastic post through the impres- patients requiring prostheses seldom present just these
sion material to the full depth of the canal (Figure ideal conditions, and the dentist must make do with the
19-31, E), syringe additional impression material best that can be devised from the dentition remaining.
around the supporting device as well as the pre- One situation to be warned against, however, is the
pared tooth (Figure 19-31, F), and seat the impres- diagonal cross-arch arrangement a molar abutment
sion tray (Figure 19-31, G). on one side, for example, and a canine on the opposite
8. Remove the impression (Figure 19-31, H), evaluate side. The rocking and torquing action set up by this
it, and pour a cast. arrangement leads to problems and loss of one or both
9. Make an interocclusal record and obtain an oppos- abutments. The molar abutment alone is preferable to
ing cast and appropriately sized plastic post to be the diagonal cross-arch situation.
used in forming a wax pattern (Figure 19-33, A). If the selected abutment teeth are reduced to a short
10. Lightly lubricate the canal of the working cast with rounded or bullet shapeliterally tucking the abut-
die lubricant (Figure 19-33, B). ments inside the denture basethe crown-root ratio of
11. Place notches on the side of a plastic post that seats the tooth is vastly improved, especially when periodon-
to the full depth of the canal preparation. tally involved teeth have lost some alveolar support. As
12. Apply a very thin layer of sticky wax to the plastic shortened teeth, however, they can serve quite well as
post and then add soft inlay wax in small incre- abutments for full overdentures.
ments, fully seating the plastic post after each
increment of wax is added (see Figure 19-33, B). Indications and Advantages
13. Ensure that the pattern is well adapted but passive The indications for overdentures include the psychic
(Figure 19-33, C). support some patients receive from not being totally
A B
D E
Figure 19-31 Post and core impression using safety pin wire and a spiral instrument
for placing impression material. A, A safety pin that will be sectioned. B, The safety pin
has been sectioned and bent so that the point extends to the depth of the post prepa-
ration and the bent portion projects above the tooth. The bent portion serves as a han-
dle and also as a means of helping retain the wire in the impression material. Note that
notches have been ground into the wire to facilitate retention of the impression mate-
rial. The wire will now be coated with impression material adhesive. C, A lentulo spi-
ral instrument that will be used to spin impression material to the apical portion of
the post preparation. The corkscrew form of the instrument, when slowly rotating
C toward the root apex in a slow-speed handpiece, spirals the impression material to the
depth of the prepared post space. D, A small portion of mixed impression material is
picked up with the spiral instrument and placed into the prepared post space. The spi-
ral instrument is being slowed rotated by the handpiece and moved up and down in
the canal to place the impression into all aspects of the prepared post space. E, A sec-
tion of the safety pin has been fully seated into the prepared post space.
G H
A B
Figure 19-32 Post and core impression using an anesthetic needle,
impression syringe, and poly (vinyl siloxane) impression material.
A, An anesthetic needle seated to the base of a prepared post space
and an impression syringe tip in position. B, Impression material
being syringed down the prepared canal. C, A plastic post that fits
passively into the canal is fully seated through impression material.
A B
C D
E F
Figure 19-33 Indirect post fabrication on a working cast. A, Working cast with plastic post around which a wax pattern will be formed. The
apical portion of the post has good approximation to the cast but is passive. B, The cast has been lubricated, a thin layer of wax applied to
the plastic post, and the post fully seated into the cast while the wax is soft. C, A plastic post removed from the cast so that the wax adapta-
tion can be evaluated. D, Wax added to the adapted post to form a core. The core will now be carved to the final form and then invested and
cast. E, Casting seated on the working cast. The cast can be hand articulated with the opposing cast to establish the required occlusal clear-
ance. F, Cast post and core cemented and preparation completed.
Figure 19-34 Overdenture abutment, well obturated and restored Figure 19-36 Mirror view of four retained abutments providing
with amalgam. Note excellent bony support. (Courtesy of Dr. David ideal support for an overdenture. Reproduced with permission
H. Wands.) from Brewer AA and Morrow RM.149
Figure 19-35 Dramatic demonstration of alveloar bone remaining around retained canines but badly resorbed under full upper and oste-
rior lower partial dentures. Reproduced with permission from Lord JL and Teel S.144
edentulous. Even more important is the preservation of densed amalgam filling is placed to cap the canal obtu-
the alveolar ridge and the shielding of the ridge from ration. At this time as well, the abutments should be
stress provided by firm abutment teeth. One should properly shaped to rise 2 to 3 mm above the tissue and
also be aware that vertical dimension is better pre- to be rounded or bullet shaped with a slope back from
served if ridge height is maintained. A bonus to all of the labial surface to accommodate the denture tooth to
these advantages is the support, stability, and retention be set above it. They should then be highly polished
derived from firm abutments. (Figure 19-37). The abutments must not be too short
or the tissue will grow over them as a lawn grows over
Contraindications a sidewalk,144 nor should they be too long, compro-
Overdentures are contraindicated when remaining alve- mising the denture contour and placing greater stress
olar support is so lacking that no tooth can be retained on the supporting teeth (Figure 19-38).
for very long. Overdentures are also contraindicated if The denture is relieved over the abutment until it fits
the remaining natural teeth are adequate to restore the securely on the tissue without touching the abutment
mouth with fixed or removable partial dentures. teeth. It is then related to the abutment teeth with a
small amount of self-curing acrylic. This proper rela-
Abutment Tooth Selection tionship of denture to tissue and tooth is important for
A healthy abutment tooth for an overdenture must denture stability and to keep the stresses on the teeth
have minimal mobility, a manageable sulcus depth, and within physiologic limits.
an adequate band of attached gingiva.145 If these pre- This entire operation is neither complex nor time
requisites are lacking, the pocket depth can be reduced consuming. Removing the crown from the tooth great-
and the attached gingiva developed by proper peri- ly simplifies and speeds the endodontic therapy. Some
odontal procedures. candidates for overdenture abutment teeth may not
need root canal therapy. The pulpless teeth may already
Abutment Tooth Location have been successfully treated. Other teeth may be so
The ideal teeth to retain are those located where abraded that the pulp has receded to a level where the
occlusal forces wreak greatest destruction on the ridges. tooth only needs shortening, proper contouring, and
Opposite a natural dentition, the canine teeth are ideal polishing (Figure 19-39).
to retain. In edentulous patients, the anterior portion If the abutment teeth are involved periodontally or
of the arches is particularly susceptible to resorption, so are not surrounded by a good collar of attached gin-
canines and premolars are again the first choice to be giva, periodontal therapy will be needed to correct
saved, with incisors the second choice. It is especially these aberrations.
important to save mandibular teeth because of difficul-
ties encountered in retaining lower dentures. Even sav-
ing a single tooth, a molar in particular, may contribute
greatly to long-term denture success.
Technique
After the selection of the proper abutment teeth, the
key to successful overdenture construction is simplicity
of technique. If an immediate denture is to be placed,
the endodontic therapy, extractions, and periodontal
treatment may all be done at the denture placement
appointment. The teeth to receive root canal fillings are
anesthetized, and a rubber dam is placed. The crowns
of these teeth are then amputated 3 to 4 mm above the
gingival level. The length of the remaining tooth is
established radiographically, and the pulps are
removed. The canals are then properly cleaned, shaped,
and obturated with gutta-percha by means of the filling
technique appropriate to the canal anatomy. The coro- Figure 19-37 Mandibular canines that have served as overdenture
nal 3 to 5 mm of the gutta-percha filling are then abutments for years. Reproduced with permission from Fenton A,
removed, the preparation is undercut, and a well-con- Brewer A. Dent Clin North Am 1973;17:723.
Figure 19-39 A, Vital teeth with severe abrasion and receded pulpsideal overdenture abutments. B, Incisor overdenture abutment not
requiring therapy owing to pulp recession. The calcified pulp area should be carefully explored for the pulp horn. (Courtesy of Dr. David H.
Wands.)
A B
Figure 19-40 A, Rather typical neglect by many denture patients. Caries and periodontal disease forecast probable lack of future patient
cooperation. B, Mirrow view of lingual gingiva of two possible overdenture abutments. Because it is virtually impossible to develop attached
gingiva in the lingual area, use of these teeth as abutments is contraindicated. (Courtesy of Dr. David H. Wands.)
A B
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24. Leary JM, Aquilino SA, Svare CW. An evaluation of post length
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INDEX
Page numbers followed by f indicate figures; page numbers followed by t indicate tables.
penetrating through dentinal tubules, Bleaching materials, 849850 of tensor villi palatini muscle, 338
96f Bleaching techniques, 854858 Butyric acid, 65
role in dentin repair, 870f Bleeding, 209
from root canals apical radiolucen- postsurgical, 714715 C
cies, 68t Block anesthesia, 679 Calciotraumatic line, 152f
Bacterial microleakage, 121 Blood pressure, 210 Calcitonin gene-related peptide (CGRP),
Bacterial pathways Blunderbuss canal 47, 176, 289
to pulp, 903t obturation of, 14f Calcium channel blockers, 335
Bacterial resistance, 905 Blunted apices, 239f Calcium hydroxide, 78, 79, 130131, 145,
Bacterial toxins, 103 Bonding adhesives, 266 148, 264, 499, 576, 670f, 804,
Bactericidal, 904 Bone 836
definition of, 80 residual infection in, 329 calcification forming around, 653f
Bacteriostatic Bone cysts, 186f, 195197 cementification, 653
definition of, 80 Bone graft in direct pulp capping for children,
Bacteroides, 68, 269 procedure for, 735 871872
taxonomic changes for, 68t Bone morphogenetic proteins pulpoto- vs. formocresol, 877
Bacteroides melaninogenicus, 501 my, 887 for incipient acute pulpalgia, 267
Balanced force concept, 535539, Bone regeneration, 719726 introduction of, 2
537f538f Bone resorption Calcium hydroxide apical filling,
Balata, 575 stimulation of, 177178 641642
Barbed broach, 486, 487f Bone wax, 697698 Calcium hydroxide apical obturation
introduction of, 2 Borrelia vincentii, 279 efficacy of, 643
Barodontalgia, 253, 270271 Bradykinins, 177, 289, 293f Calcium hydroxide cement, 134
Barrier techniques Branched primary afferent hypothesis, Calcium hydroxide pulpotomy, 882884
of disinfection, 8485 316f in primary teeth
Baseplate gutta percha, 213 Breakdown theory, 183 outcomes of, 883884
Basophils, 178 Breast cancer, 255f in young permanent molar, 883f, 885f
Battered child syndrome, 796 metastatic, 197, 197f in young permanent teeth, 884, 884f
BDI/BDI-II, 298299 Broken instrument Calcium hydroxide sealers, 586
Beck Depression Inventory (BDI/BDI- past apex Calcium phosphate cement, 653654
II), 298299 treatment of, 784f in direct pulp capping for children,
Benign cough headache, 326 Bruxism, 272, 313, 946f 874
Benzodiazepines, 911 adolescent female, 114 overfill of, 654f655f
Benzoyl peroxide, 129130 Buccal gingival sulcus Calcium phosphate cement obturation,
Beta-adrenergic receptors, 679 furcation draining through, 112f 653654
Beyond a reasonable doubt, 21 Buccal roots Calcium phosphate obturation, 585
Biaxin, 906 total amputation of, 11f Calcium phosphate pulpotomy, 887
Bicuspidization, 722723, 726 Bufferin, 910 Calcium sulfate, 700
Bifurcations, 412f Built-in apex locator, 491 Callahan-Johnston technique, 614
Bilateral oblique root amputation, 725f Bulls-eye phenomena, 229f, 230f Camera
Biocompatibility, 145 Bupivacaine, 678, 716 for endoscopy, 378
Biofeedback, 335336 for SAP, 276 Camera coupler/lens
Biohazardous waste Burning mouth syndrome, 347348 for endoscopy, 378
definition of, 80 Burning tongue, 347348 Camphorated chloroxylenol (ED84), 79
Biomedical waste Burs Camphorated monoclorophenol (CMCP)
definition of, 80 extra-coarse dome-ended cylinder introduction of, 2
Bis-dequalinium acetate, 501 diamond vs. round tungsten Cancer screen, 210
Bisection, 722723, 726 carbide burs, 407f Canine
Black, G.V., 865 in handpiece trauma, 165f
Black eye for endoscopy, 381f Capillary loop
following periradicular surgery, 716f for hard tissue removal, 683f through odontoblasts, 49f
Black-pigmented bacteria, 68 plain fissure, 683 Capsaicin, 334
Blacks principles, 408 for root-end resection, 702 Capsulitis, 312
total endodontic cavity preparation, round Carbamazepine, 330, 332
471f for dentin removal, 406 Carbamide peroxide, 850
Blacks spoon excavator round-end carbide fissure, 405 Carbocaine, 678
vs. long-blade endodontic spoon round tungsten carbide Carbon dioxide dry ice stick, 212213,
excavator, 413f vs. extra-coarse dome-ended cylin- 213f
Bleaching der diamond burs, 407f Carbon dioxide lasers, 551, 683
complications of, 852853 tapered forcing of, 408f Carbon fiber post
Bleaching gel, 850f Bursitis placement of, 935f
Carbonic gas laser, 122 Cell-inductive agents crown root fracture of, 813f815f
Carboxylate cement, 705 in direct pulp capping for children, incisal view of, 915f
Carcinoma, 198 874 trauma to, 800f
Caries Cell-mediated immune reactions, uncomplicated fracture of, 803f
advanced, 946f 178179 Central nervous system syndromes, 321
control of, 148149 Cell-rich zone, 32 Central ossifying fibroma, 193f
coronal, 9697 Cellulitis, 64, 69 Central pulp zone, 32, 34f
decline of, 4 dissolution of, 674f Central sensitization, 291f
enamel fissure, 97f treatment of, 7476 Cephalexin, 79, 735
root, 108111 Cement, 581583 Cephalosporins, 905
teenager, 9f calcium hydroxide, 134 anaphylactic allergic reaction to, 904
toothworm theory of, 12 calcium phosphate, 653654 examples of, 904t
Carious dentin, 29f in direct pulp capping for chil- resistance to, 904905
removal of dren, 874 Cephalothin sodium
in endodontic cavity preparation, overfill of, 654f655f in direct pulp capping for children,
412413 carboxylate, 705 873
tubule colonization, 153f forced into pulp, 119f Cervical canal perforations, 777778, 778f
Carotid artery glass ionomer, 131132, 146147, 705 Cervical ferrules
pain from, 318320 temporary replacements, 630 tooth fracture, 926928
Carotid artery pain, 327 IRM, 126 Cervical joint dysfunction
Carotid pain, 318 N2 pain from, 319320
Carotid sinus, 52 legal status of, 592593 Cervical pain disorders, 294
Carotidynia, 318319 oxyphosphate of zinc Cervical spine
Case selection introduction of, 2 pain from, 319
errors in, 755757 polycarboxylate, 126 Cetirizine, 906
Cast crowns in direct pulp capping for chil- C fibers, 263
static vs. dynamic cementation seating dren, 873 CGRP, 47, 176, 289
of, 147f RC2B, 594f Charge coupled device (CCD), 370
Catecholamines legal status of, 592593 Cheeks
influence of, 336f overextension, 596f lacerated, 798f
Causalgic pains, 335336 root canal Chelating agents, 504505
Cavit, 705 mixing, 604f Chelation, 2
Cavity solubility of, 581f Chemclave, 82
toilet of, 413416 tissue tolerance of, 587596 Chemical burns
Cavity bases, 134, 144145 sealer, 497498 caused by hydrogen peroxide, 853
Cavity liners, 134, 144145 silicate, 124, 124f Chemical hazards, 86
Cavity preparation, 115119 tissue response to, 125f Chemical vapor sterilization, 82
carious dentin removal, 412413 tetracalcium phosphate-based Chief complaint, 206, 211
cavity toilet, 413416 in direct pulp capping for chil- for dental trauma, 796797
convenience form, 409412, dren, 874 Child abuse, 796
414415p2 zinc phosphate, 125, 132, 705 Children
defective restoration removal, ZOE. See Zinc oxide-eugenol cement direct pulp capping in, 868875
412413 Cement bases, 145 indirect pulp capping in, 864868
depth of, 117, 144 Cemented post/restorative material core pulp morphology in, 861863
divisions of, 405 prefabricated, 932933 pulp therapy in, 864
heat during, 144 Cemented primary point, 605 Chlorhexidine, 498, 577, 678, 735
heat of, 115117 Cementification Chlorhexidine gluconate, 146, 500501
outline form, 408409, 410411p1 calcium hydroxide, 653 Chlorine dioxide, 83
principles of, 408416 Cementing Chloroform, 614, 646, 851
pulpal inflammation induced by, 116f force of, 121 Chloroform dip technique, 611612,
to receive composite filling materials, Cementoblastoma, 190, 192f, 243 611f
133 chronologic development of, 245f Chloropercha, 614615, 615f
width of, 144 Cementodentinal junction Chromic gut sutures, 710
CBF-alpha, 27 definition of, 511 Chronic apical abscess, 243f
CCD, 370 Cementum Chronic apical periodontitis, 240f, 278
C3 complement, 177 deposition, 30 Chronic fistula, 252f
Celebrex, 911 development of, 2627 Chronic Illness Problem Inventory
Celecoxib, 911 Central carrier, 635 (CIPI), 298299
Cell bodies Central giant cell granuloma, 194, 194f Chronic pain, 294299
odontoblasts, 36f Central incisors Chronic paroxysmal hemicrania (CPH),
Cell-inductive agent pulpotomy, 887888 with apical root fracture, 821 324325
Irration dentin, 29f Laser-assisted canal preparation, 550554 Local myalgia, 337
Irreversible pulpitis, 97103, 156157 Laser burn, 122 Lock jaw, 337
Irrigant-related mishaps, 789790 Laser Doppler blood flow, 51 Long-blade endodontic spoon excavator
Irrigating needle, 502503 Lasers vs. Blacks spoon excavator, 413f
Irrigating system, 502f hydroxyapatite, 655 Long cone radiography, 359
Irrigation, 498500 pulpotomy, 888889 Loosened posts
comparative studies of, 502503 for root-end resection, 683 mandibular molar crown, 917f
complication of, 498 Lateral canal Loratidine, 906
complications of, 502 warm gutta percha vertical com- Lorazepam, 911
method os use, 502503 paction, 622f Lovastatin, 906
and smear layer removal, 503505 Lateral compaction Lower molar
Irritants, 175 comparative results of, 614f distal canal
Irritation of curved canals, 609 Lentulo spiral fracture, 604f
hard tissue response to, 149153 efficacy of, 612 Luting agents, 132
periradicular reaction to, 176 fractures from, 607609 Luxated teeth, 11, 828f, 832f
Irritation dentin, 124, 149153, 153f multiple-point obturation, 605606 Luxation, 112, 825f
adjacent to zinc phosphate cement, nickel titanium spreaders, 609612 Luxation injuries, 821822
125f of primary gutta percha point Lymphatic capillaries, 41f
formation of, 101f, 264 in curved canal, 609f Lymphocytes, 35, 74
in mandibular premolar, 150 Schilders concept, 612f Lysosomal enzymes, 177
ISO, 473 SEM cross-section, 607f
instrument grouping, 474486 stress from, 607609 M
Isobutyl cyanoacrylate Lateral luxation, 823 Macrolides, 905906, 906t
in direct pulp capping for children, Lateral midroot perforation, 718f Macrophages, 34
873 Lateral perforation, 779f Major muscle attachments
Lateral periodontal cysts, 188189, 189f incisions across, 682
J Lateral radicular cysts, 189 Malignancies, 197198
James, William, 357 Laundering, 85 Malingering, 307
Japanese Ledermix Malpractice, 791
and one appointment therapy, 16 in direct pulp capping for children, Mandibular anesthesia, 385
Jaw claudication, 326 873 Mandibular anterior teeth, 368f, 369f
Jaw fractures, 840 Ledge formation, 776777, 777f burs for, 406
Left central incisors cavity preparation errors of,
K replanted, 836f 418469p11
Keflex, 735 Length-of-tooth measurement, 514f endodontic preparation of,
Keflin initial, 515f 418469p8
in direct pulp capping for children, Lentulo spiral fracture radiography
873 lower molar horizontal angulation, 365366
Kells, C. Edmund, 357 distal canal, 604f rectangular flap for, 684
Kinins, 176 Leubke-Ochsenbein flap, 684685 Mandibular block, 385
Kloropercha, 614615 Leukotrienes, 177178, 289 Mandibular canine abutment
Knowledge Levarterenol, 678 canals of, 696f
of diagnostician, 203 Levonordefrin, 678 Mandibular canines
K-style instruments, 477f Levophed, 678 fast break, 228f
manufacture of, 475 Lidocaine, 392f, 678 multiple/extra canals in, 417
rotary, 493 LightSpeed endodontic instruments, pulp anatomy and coronal prepara-
K-style modification, 475 548549, 548f tion of, 418469p10
Limited mucoperiosteal flaps, 684685, serving as overdenture abutments,
L 686 944f
Labial cortical plate Linear calcifications, 4445 Mandibular central incisors
surgical trephination of, 677f Lioresal, 330331 pulp anatomy and coronal prepara-
Laboratory coats, 85 Lips tion of, 418469p9
Laboratory waste lacerated, 798f Mandibular first molars
definition of, 80 numb, 18 distal canals, 508
Lacerated cheeks, 798f Liquefaction necrosis, 160f postspace perforation of, 724f
Lacerated lips, 798f Liquid crystal testing, 216 pulp anatomy and coronal prepara-
Lactobacillus casei, 102 Liver dysfunction, 678 tion of, 418469p25
Lamina dura, 223f Local anesthesia, 673674, 716 Mandibular first premolars
Large canal atraumatic, 384t vs. mandibular second premolar,
total pulpectomy, 556557 introduction of, 2 750751
Laser-activated bleaching, 856 techniques of, 385 pulp anatomy and coronal prepara-
tion of, 418469p17 flat fingertip palpation of, 344f palatal canals of, 509510
Mandibular first primary molars referred pain from, 340f radiograph
formocresol pulpotomy Mast cells, 35, 177, 178 horizontal angle, 363364
failure of, 879f Master point, 605, 605f Maxillary premolars, 12f, 368f
Mandibular fractures, 839840 Masticatory elevator muscle spasm, 295 cavity preparation errors of,
Mandibular incisors Maxillary anesthesia, 385 418469p15
fracture of, 608 Maxillary anterior teeth endodontic preparation of,
pulp death of, 114f cavity preparation errors in, 418469p12
root canals, 508 418469p3, 418469p7 radiography
sclerosed canals, 208f radiography horizontal angulation, 365
Mandibular lateral incisors horizontal angulation, 366 Maxillary second molars
multiple/extra canals in, 417 warm gutta percha vertical com- four canals, 618f
pulp anatomy and coronal prepara- paction, 621622 pulp anatomy and coronal prepara-
tion of, 418469p9 Maxillary arch tion of, 418469p22
Mandibular molar crown anatomic landmarks in, 222f Maxillary second premolars
loosened posts, 917f Maxillary canines excessive post diameter, 925f
Mandibular molars, 29f dentin discoloration of, 846f necrotic pulp in, 31
cavity preparation errors in, with destroyed crown, 393f pulp anatomy and coronal prepara-
418469p27 pulp anatomy and coronal prepara- tion of, 418469p14
C-shaped canal in, 558f tion of, 418469p6 Maxillary sinus
with deep carious lesion, 151f pulp necrosis of, 846f apical perforation into, 644f
distal post, 923f rectangular flap for, 684 McGill Pain Questionnaire, 297298,
endodontic preparation of, Maxillary central incisors 298t
418469p24 apical abscess, 801f Mechanical attachments, 945947
with furcal bone loss, 10f curvature of, 776 Mechanical perforation repair, 780f
hemisecting and restoring, 721f dentin discoloration of, 846f Medical history, 209
hemisection of, 725, 728f fracture of, 608 for dental trauma, 797
multiple/extra canals in, 416417 intrusion, 827f Medical history form, 205t
orifices of, 507 pulp anatomy and coronal prepara- Medically compromised patients
radiograph, 364f tion of, 418469p4 prophylactic antibiotics for, 7677
horizontal angle, 362 traumatic pulp necrosis of, 846f referral of, 19
Mandibular posterior teeth Maxillary first molars Medical solid waste, 81
triangular flap for, 684 following root-end resection, 739 Medicaments
Mandibular premolars mesiobuccal root of, 507 applied to dentin
anatomical differences in, 750751 pulp anatomy and coronal prepara- chemical injury through, 144145
cavity preparation errors in, tion of, 418469p21 Medications
418469p19 Maxillary first premolars in direct pulp capping for children,
endodontic preparation of, orifices of, 507 871
418469p12 pulp anatomy and coronal prepara- history of, 209
ethnic differences, 751 tion of, 418469p13 Medullary bone
with irritation dentin, 150 Maxillary fractures, 839840, 840f radiography of, 358
multiple/extra canals in, 417 Maxillary incisors Membrane placement
pulp anatomy and coronal prepara- anomalies of, 106f procedure for, 735
tion of, 418469p16 with coronal fractures, 14f Mental foramen, 221f
radiograph, 366f pulp exposure in, 115f posterior mandibular surgery, 689
horizontal angle, 362363 triangular flap for, 684 Mentally compromised patients
working length film, 510f Maxillary lateral incisors referral of, 19
Mandibular second molars beveled surface of, 738f Meperidine, 910
cross section of, 507f failures in, 751 for AAA, 277
distal canals, 508 pulp anatomy and coronal prepara- for SAP, 277
multiple/extra canals in, 417 tion of, 418469p5 Mepivacaine, 678
pulp anatomy and coronal prepara- root resorption, 756 Mesial root
tion of, 418469p26 root tip biopsy from, 751f amputation of, 727f
Mandibular second premolars Maxillary molars, 367f canals in, 508f
vs. mandibular first premolar, amputation technique for, 723725 warm gutta percha vertical com-
750751 cavity preparation errors, 418469p23 paction, 622f
pulp anatomy and coronal prepara- crown destruction in, 413f Mesiobuccal canals, 227f, 781
tion of, 418469p18 endodontic preparation of, bifurcation, 228f
Marcaine, 678, 716 418469p20 orifices of, 507
Marginal fit, 146 multiple/extra canals in, 416417 Mesiobuccal root
Masseter muscle, 343f orifices of, 507 of maxillary first molar, 507
Mesiolingual canal internal resorption of, 163f muscle palpation for, 344f
separated rotary instrument in, 783f invasive resorption, 209f Myositis, 337
Metabolic disorders mesial root of, 224f Myospasm, 336337, 337
headaches associated with, 327 noncarious adult, 154f
Metastatic breast cancer, 197, 197f occlusal amalgam of, 208f N
Methacrylic acid, 129 pulp death in, 232f N2
Methylcellulose-based liners, 134 pulp necrosis in, 157f overfill, 595f
Metronidazole, 74, 759, 904, 905 pulp polyp in, 159f Nabatean warrior
Mevacor, 906 Monitors root canal filling of, 1f
Microabscess radiography Naloxone, 910
in pulp horn, 160f buyers guide, 374 Naproxen
Microbes, 757759 Monopotassium-monohydrogen oxalate, for SAP, 276
Microbial irritants, 175176 265f Narcan, 910
Microbial microleakage, 124, 133, 134, Morphine, 910 Narcotics, 908, 911
145 Motrin, 910911 Nasal mucosa,
prevention of, 129, 130f, 144 Mouthguard bleaching, 856858 inflammation of, 310f
Microbial sample adverse effects of, 857858 Nasopalatine canal
collection of, 77 indications and contraindications for, cyst of, 243f
Microfibrillar collagen hemostat, 701 857t Nasopalatine duct cysts, 194195, 195f
Microleakage Mouth rinse National Health Interview Survey, 259
final coronal restoration, 651652 presurgical, 677678 National standard of care, 17
Micro-mirrors, 704f MPI, 299 N2 cement
Microsurgery, 736739 Mucoperiosteal flaps, 683 legal status of, 592593
Midazolam, 384 Mucosal damage Nd:YAG laser, 122, 551, 552f, 683
Middle superior alveolar nerve block, after thermo-photo bleaching, 856 pulpotomy, 888889
385, 388, 389t following mouthguard bleaching, 857 Neck
Midroot perforations, 718, 778781 Multidimensional Pain Inventory (MPI), physical examination of, 303
repair, 780f 299 Necrosis, 159160
Migraine, 322324 Multiple foramina Necrotic pulp
with aura, 322 incidence of, 30 in maxillary second premolar, 31
history of, 301 Multiple-point obturation Needles
with tension-type headache, 345346 with lateral compaction, 605606, selection of, 711
triggers of, 302 606f Needlesticks, 79, 86
without aura, 322323 Multiple sclerosis Negligence, 644f
Milk demyelinating lesions associated with, Neo-Cobefrin, 678
as transport medium, 833 329 Neodymium-yttrium-aluminum-garnet
Miller, W.D., 865 Multirooted teeth (Nd:YAG) laser, 122, 551,
Mineral trioxide aggregate, 655, 705707, root selection for, 931 552f, 683
706f, 773, 774f, 831f Mumps, 308 pulpotomy, 888889
carriers for, 708f Munchausen syndrome, 307 Neomycin
in direct pulp capping for children, Muscle spindle in direct pulp capping for children, 873
874 cross-section of, 341f for SAP, 276
pulpotomy, 887 Muscle tension, 303 Nerve block
Minnesota Multiphasic Personality Muscular pains, 336346, 336t Akinosi-Vazirani closed-mouth
Inventory (MMPI/MMPI- Myalgia mandibular, 385
II), 299 local, 337 anesthesia, 679
Missed canals, 770772, 771f Mycobacterium tuberculosis, 80, 8384 anterior superior alveolar, 385, 388,
Missing teeth Mycoplasma, 847 389t
statistics, 4 Myelin degeneration, 329 Gow-Gates mandibular, 385387
Mixed culture, 69 Myocardial infarction, 285, 316318, incisive, 387388
MMPI/MMPI-II, 299 317f inferior alveolar, 385
Mobile cart Myofascial pain, 337345 injection, 673
for endoscopy, 377f case history of, 342343 middle superior alveolar, 385
Moderate acute pulpalgia, 266267 etiology of, 338 posterior superior alveolar, 385
Modulation, 291 examination of, 343 Nerve paresthesia, 787788
Molars pathophysiology of, 338342 Nerves, 4142
carious dentin in, 156f symptoms of, 338 Nervus intermedius neuralgia, 329, 331
carious exposure in, 158f treatment of, 343345 Net income
with deep caries, 159f triggers of, 302 of dentists, 4
extraction of, 335 Myofascial trigger points, 292, 302 Neuraliga-inducing cavitational
furcation area of, 30 examination of, 304 osteonecrosis (NICO), 329
diagnosis of, 299307, 306t Particle size, 580 Periodontal pockets, 110, 756
family history of, 302303 Paste fillers bacteria moving from, 113f
history of, 301303, 301t rotary, 604f Periodontal repair, 719726
intracranial causes of, 321t Paste-type fillings Periodontal therapy, 392393
neural structures relevant to, 289f risks of, 786f Periodontitis, 178, 218f
neurologic examination, 305 Pathogenicity Periosteal elevators
neurophysiology of, 288297 definition of, 6465 for flap reflection, 688f
physical examination of, 303305, Patience Peripheral pulp zone, 3132
303t of diagnostician, 204 Periradicular cemental dysplasia,
physiologic mechanisms modifying, Patient communication 189190, 190f192f
294296 for surgery, 677 Periradicular curettage, 122123, 692
postsurgical, 715716 Patient history, 204209, 260 causing pulp death, 123f
produced by air blast, 261f for dental trauma, 796 Periradicular cysts, 181
psychological assessment of, 298299 Patient records, 2021 Periradicular granuloma, 180181, 614f,
psychological factors modifying, Patients 751
296297 evaluation for transmissible disease, Periradicular infections, 6974
quality of, 200 81 endodontic flora in, 70f
social history of, 303 Pediatric. See Children Periradicular inflammation, 572
Pain assessment tools, 297299 Pedunculated tumors, 321 Periradicular inflammatory soft tissue
Pain behaviors, 296297, 306307 Penicillin, 905 curettes for removing, 692f
Painful anesthesia, 334 in direct pulp capping for children, Periradicular lesions, 11, 175198, 244f,
Painful disorders 873 723f
taxonomy of, 287288 oral clinical classification of, 179
Pain management, 381382, 908911 anaphylactic allergic reaction to, failure, 762f
mandibular techniques, 385386 904 frequency of, 645f
maxillary techniques, 388 examples of, 904t healed, 752f
supplemental injection techniques, resistance to, 904905 mediators of, 176177
388389 Penicillin VK, 75, 76 radiographic examination of, 238244
Pain pathways Peptostreptococcus, 68, 759 repair of, 186187
acute, 288291 Perception, 291 Periradicular osteofibrosis, 243
Pain reaction threshold, 383 Percussion, 213 Periradicular pain, 275278
Pain-sensitive structures Perforations, 777 Periradicular plaque, 72f
traction on, 321 repair, 717719 Periradicular puff, 573, 573f
Pain threshold, 296 Periadicular pathogenesis, 74 Periradicular radiographs, 305307
Pain tolerance, 296 Periapex Periradicular region
Palatal root diagrammatic view of, 511f histology of, 5355
apical curve to, 526f radiolucency relationship to, 221f Periradicular repair, 641f
Palatal surgery Periapical actinomycosis Periradicular surgery, 675727
flap design for, 685686 treatment of, 7879 trapezoidal flap for, 684
Palatogingival groove Periapical bone Permanently cemented crowns
surgical exposure of, 728f resorption of, 74 preventing damage to, 772
Palpation, 213, 214f Periapical periodontitis, 762t Permanent teeth
Pamphlets, 5 nonsurgical endodontic retreatment direct pulp capping
Panoramic radiographs, 305307 outcome, 763t clinical success of, 870
Paper points Pericoronitis, 279 eruption of first, 26
absorbent, 517f Peridex. See Chlorhexidine gluconate vs. primary teeth, 861862, 862f
confirming strip perforation, 779f Perimeter filling action, 530f young. See Young permanent teeth
Paraformaldehyde Periodontal abscess, 110 Persistent discomfort, 251254, 253f
nerve damage from, 593596 Periodontal curettage, 122 Pharynx
toxicity of, 593 Periodontal disease pain in, 329
Parallel-sided cemented posts influencing prognosis, 217 Phenol, 138, 144
fracture rate, 920 Periodontal evaluation, 217 Phenolics
Paranasal pain, 284, 309311 Periodontal lesions, 10 causing tooth discoloration, 849
Parental consent, 20 pain, 278279 Phenothiazine, 347
Paresthesia, 18 Periodontal ligament Phentermine, 908
Parotitis, 308 injection, 385, 389t Phenylephrine, 698
Paroxysmal neuralgia, 327332 needle insertion for, 390f PHN, 332333, 333334
Partial pulpectomy, 555f, 557, 574f injury to, 799 Phoenix abscess, 182
Partial pulpotomy, 804, 805f proprioceptors of, 53 Physical status classification
in direct pulp capping for children, Periodontal ligament space of ASA, 206t
871 needle penetrating, 390f Pin insertion, 119
into coronal pulp, 120f Postoperative sensitivity, 145 pain to, 731f
Pink tooth, 236f, 272 Posts Presurgical mouth rinse, 677678
Pins apical periodontitis, 916 Pretrigeminal neuralgia, 328, 330
causing tooth discoloration, 849 causing tooth discoloration, 849 Prevotella, 759
Piroxicam clinical failure rate of, 916917, 917t Prevotella intermedia, 68, 74
for SAP, 276 clinical loss of retention associated extracellular vesicles, 65f
Pivot crown, 913 with, 918t Prevotella nigrescens, 68
Pivot tooth, 913f, 914 clinical tooth fractures associated Price, Weston A., 357
Plain fissure burs, 683 with, 919t Prilocaine, 678
Plasma cells, 35 coronal portion of, 936f Primary afferent nociceptor fibers
Plastic disposable syringe and needle, custom-cast, 930f of trigeminal nerve, 294f
502f design of, 918919 Primary afferent nociceptors, 288
Plasticized gutta percha diameter, 923, 928 sensitization of, 289
extruded from syringe overfills, 634f root perforation, 924925 Primary gutta percha point
Plastics, 126127, 583584 tooth fracture, 923924 lateral compaction of
salivary leakage around, 128 excessive diameter, 924f in curved canal, 609f
Plastic sealers, 586587 form Primary hyperalgesia, 289
Plexus of Raschkow, 41 root fracture potential, 919922 Primary osteoarthritis, 314315
Poliovirus, 8384 Kaplain-Meier survival data, 917t Primary point, 605, 605f
Polyacrylic acid, 146 leakage, 643645 Primary roots, 862
Polyamines, 65 length, 922923, 928 Primary teeth
Polyarthritides, 312313 length and diameter selection, 914f calcium hydroxide pulpotomy in
Polycarboxylate cement, 126 placement techniques, 928931 outcomes of, 883884
in direct pulp capping for children, pulpless teeth, 915916 complicated crown fractures of,
873 purpose of, 916 808809
Polyglactin sutures, 710711 removal of, 647649 deep carious lesions in, 863864
Polyglycolic acid sutures, 710 space preparation widths, 925t direct pulp capping
Polymorphonuclear leukocytes, 34 type of, 929931 clinical success of, 871
Polymorphonuclear neutrophil leuko- Post space perforation, 789 discolored, 833f
cytes, 289 Postsurgical care, 713717 eruption of first, 26
Polyvinylpyrrolidone-iodine, 86 Post-traumatic neuralgia, 334 formocresol pulpotomy in
Pondamin, 908 Post-treatment evaluation radiography, one-appointment, 879, 879f880f
POOR PAST, 256 246 outcomes of, 877878
Popcorn kernel, 759f Posture, 304, 319 technique for, 878879
Porcelain-fused-to-metal restorations, effect on pulpal pain, 5153 two-appointment, 879880
405 Potassium clavulanate injuries of, 829831, 833f
Porphyromonas, 759 with amoxicillin, 904905 nonvital pulp therapy in, 889890
Porphyromonas gingivalis, 69, 74 Potassium nitrate, 266 vs. permanent teeth, 861862, 862f
Postbleaching external root resorption, Potassium oxalate, 264 pulp inflammation in, 863864
853f Predentin, 144 pulpotomy of
Postbleaching tooth restoration, 854 Prefabricated cemented post/restorative treatment approaches for, 876
Post designs material core, 932933 replantation of, 838
prefabricated, 930f Prefabricated orthodontic band, 395f Procaine, 678
Posterior mandibular surgery Prefabricated post designs, 930f Procedural barriers
mental foramen, 689 Prefabricated threaded post/restorative for disinfection, 8586
Posterior superior alveolar nerve block, material core, 936 Prochlorperazine, 337
385, 388t Premolars Prodromal auras, 324
Posterior teeth bayonet curvature, 229f Profound anesthesia
coronal crowns of, 915 failure, 757f pulpectomy, 556
triangular flap for, 684 mesial curvature, 229f Prognosis, 761
Post failures, 917918 multiple/extra canals in, 417 factors influencing, 217218
Post form three-rooted, 225f Prophylactic antibiotics
tooth fracture, 921t undetected fracture in, 105f for dental procedures, 76t
Postherpetic neuralgia (PHN), 332334 Preoperative pain, 274 for medically compromised patients,
Post impression, 940f941f Preoperative pulp necrosis 7677
Postoperative care treatment outcome, 748f Propionibacterium, 759
instructions for, 714t Preoperative therapy, 275 Propoxycaine, 678
Postoperative failure, 758f Preponderance of evidence, 21 Propoxyphene, 908
Postoperative pain, 274275 Present dental illness, 206209 Proprioceptors, 53
after thermo-photo bleaching, 855 Preservation, 876 Propulsid, 906
with one appointment therapy, 15 Pressure, 715 Prostaglandins, 74, 177, 289
Root canal filling, 121 Root canal therapy vs. stainless steel K-type files, 540f
annually, 3 and radiographs, 361 U-blade design, 541
extension of, 573574 Root caries, 108111 Rotary paste fillers, 604f
failure of, 578f and resorption, 719 Rotary U-type instruments, 493
instrumentation, 573f Root curvature Round burs
oldest known, 1f and post length, 929 for dentin removal, 406
Root canal irrigants, 498499 Root-end closure Round-end carbide fissure burs, 405
Root canal medication, 764, 764f induction of, 830f Round tungsten carbide burs
Root canal obstructions Root-end filling, 705708 vs. extra-coarse dome-ended cylinder
ultrasonic/sonic removal of, 649 material carriers, 707f diamond burs, 407f
Root canal orifice materials for, 705708 Rubber dam, 8586
access to of maxillary canine, 738f application of
in convenience form, 409 placement and finishing of, 707708 technique of, 398
exploration for, 505508 Root-end resection, 692697 clamps, 396398
Root canal pastes angle of, 695697 failure to use, 791
tissue tolerance of, 587596 bur preparation for, 702 and fractured teeth, 402f
Root canal preparation, 932, 933f extent of, 694695 frames for, 396
automated devices for indications for, 693 introduction of, 2
efficacy and safety of, 496497 instrumentation for, 693694, material for, 395
Root canals 701702 punch for, 395396
anatomy of, 2829 preparation for, 697705 Rubber dam application, 394402
impacting treatment failure, ultrasonic, 702705 double-bowed clamp, 400402
750751 using laser energy, 695f equipment for, 395398
apical diameters, 30 Root extrusion using single-bowed clamp
with apical radiolucencies basic technique for, 812f dentist role in, 398400, 399f
bacteria from, 68t Root-form osseointegrated implants, variations of, 401
bleeding control of, 557558 733736 Rubber dam frame, 396f
chelation and enlargement of, Root fractures, 607f, 723f, 811821, Rubber dam retainer
532533 816f820f floss around, 792f
cleansed, 555f diagnosis of, 811812 Ruby laser radiation, 122
complete obliteration of, 599f incidence of, 811
debridement of, 7778, 557558 and post form, 919922 S
drying of prognosis of, 820821 Saliva ejector
in radicular space obturation, 603 sequelae to, 818 for rubber dam, 398
effect on irrigant, 502 treatment of, 812820 Salivary gland disorders, 284, 308
fungus in, 73f vertical, 788, 788f Salivary leakage
intracanal medication, 7879 on endodontically treated tooth, around plastics, 128
obliterated, 18 811f Salivation, 329
in outline form, 409 with overzealous canal prepara- Salmonella typhosa
overextending, 18 tion, 776f and sodium hypochlorite, 499500
preparation and obturation Root perforation, 250f Salvizol, 500, 500f
ideal termination of, 572f causes of, 753 Same Lingual, Opposite Buccal, 362, 363f
primary vs. permanent teeth, 862 with incomplete debridement, 755f Sarcoma, 198
in radicular cavity preparation post diameter, 924925 Sargenti endodontic technique, 21
cleaning and debridement of, 470 Root-resorptive defect Sargenti Method, 592593
preparation of, 470471 corrective surgical repair of, 720f Scalpel blade, 686f
radiography of, 358f Root selection Scalpels, 86
shaping of for multirooted teeth, 931 Scanning electron microscopy, 683
objectives of, 496 Root tip Schilders concept
space between walls, 557f fracture of, 671f lateral compaction, 612f
underfilled, 18 Rotary contra-angle handpiece instru- Scoop technique, 86
unsuspected anatomical aberration ments, 491 Sealants
in, 528f Rotary drill-type instruments, 493 adhesion of, 586
Root canal sealers Rotary H-type instruments, 493 obstacles, 584585
osseous implants of, 589 Rotary instruments, 144, 492498 Sealer cement, 497498
subcutaneous implants of, 588589 breakage of, 782783 Sealers, 579581
tissue tolerance of, 587596 causing temperature rise in pulp, 117 apatite, 655
in vivo tissue tolerance evaluations, Rotary K-type instruments, 493 calcium hydroxide, 586
589593 Rotary nickel titanium, 540550 cytotoxic evaluation of, 587
warm gutta percha vertical com- canal preparation, 342 epoxy resin, 579
paction, 618 principles of, 550 experimental, 584
experimental calcium phosphate, 587 Silver points, 497498, 577578, 579f Spongostan, 701
glass-ionomer, 652 removal of, 647649, 648f, 649f, 926 Spontaneous electrical activity, 338339
mixing and placement of Silver point technique, 637638 Spoon excavator
in radicular space obturation, Silver root canal point, 23, 13f long-blade endodontic
603604 SimpliFill obturation technique, 638639 vs. Blacks spoon excavator, 413f
plastic, 586587 Single interrupted suture, 711712 Spray and stretch, 343344, 345
removal of, 645646 Single root amputation, 726727 Spreaders, 605
retreatment following, 646647 Single sling suture, 686f, 713, 714f hand vs. finger, 608
resin-type, 586587 Single-visit endodontics, 1516 size and taper
root canal Sinusitis, 243f, 284, 310, 644f in multiple-point obturation,
osseous implants of, 589 Sinus pain, 284, 309311 606607
subcutaneous implants of, Sinus tract size determination of, 600601
588589 diagnostic perplexities of, 250251 standardized, 599f
tissue tolerance of, 587596 Sjogrens syndrome, 308 Spreaders/pluggers, 600, 608f
in vivo tissue tolerance evalua- SLOB rule (Same Lingual, Opposite Spreading muscle spasm, 295
tions, 589593 Buccal), 362, 363f Sproless cervical pulp horns, 118f
warm gutta percha vertical com- Slow-speed handpiece occurrence of, 118t
paction, 618 engine-driven instruments, 492f Squamous cell carcinoma
Secondary mechanical hyperalgesia, 291 Small canal gingiva, 198
Secondary osteoarthritis, 314315 total pulpectomy, 557 Stabilization splint, 313
Second molars Smear layer, 146 Stainless steel files, 528f
periradicular lesion, 644f removal of, 503505 bending of, 480
Second-order pain transmission neurons, in root-end filling, 707708 metallic memory of, 482483
288 Smooth broach, 486 Stainless steel K-type files
Sectional gutta percha obturation, 624f Sodium fluoride, 138, 264 vs. rotary nickel titanium, 540f
Seldane, 906 Sodium hypochlorite, 78, 83, 497, Stannous fluoride, 264
Semilunar flap, 684 498500, 503 Staphylococcus, 759
Senses in combination with other medica- Staphylococcus aureus, 764f
of diagnostician, 204 ments, 499500 and sodium hypochlorite, 499500
Sensitization, 294295 inadvertent injection of to maxillary Statute of limitations, 21
Sensors, 373f premolar, 790f Stelazine, 337
Sensory nerve, 42f shelf life of, 499500 Stellate ganglion
Sensory threshold, 296 Sodium perborate, 849850, 850f repeated blocks of, 335
Separated instruments, 782785 Soft tissue Step-back preparation, 470471,
instruments for retrieving from root injuries of, 801 525527, 527f
canal, 783f management of, 680690 configurations, 531f
Separated rotary instrument repositioning and compression, 709 and curved canals, 525527
in mesiolingual canal, 783f repositioning and suturing of, efficacy, 530
Serotonin, 177, 178, 291 708713 hand instrumentation, 528530
Serrated post, 930f suturing of, 709710 modified, 530
Serratia marcescens, 104 trauma Step-down preparation, 470471, 508f,
Sexual excitement, 326 examination of, 797 533535, 536f537f, 539
S file, 484 Solid core carrier, 633636 curved instrument, 533
Shallow pulpotomy, 804, 805f Solid core materials efficacy, 535
Sharp instruments, 86 for radicular space obturation, 575 hand instrumentation, 533
Sharps, 80 Somatic delusions, 306 K-file series, 533
Sheaths Somatization, 307 modified, 533534
for endoscopy, 378, 379f Sonic canal preparation and debride- Sterilization
Shingles, 143, 143f, 332333, 333f ment, 539540 definition of, 80
Shock, 260 efficacy and safety of, 540 Sterilized towel kit
Shoes, 85 Sonic handpieces, 493496 for endoscopy, 380, 380f
Short cone radiography, 359 Sotokawas classification Sternocleidomastoid muscle
Shrinkage stresses, 147148 of instrument damage, 481f pain reference from, 341f
Sialolith, 207f, 308 Specimens, 80 Stop attachments, 512153, 513f
Sickle cell anemia, 143 Spinal accessory nerve (cranial nerve XI), Storage phosphor systems, 370
Silicate cement, 124, 124f 305 Straight instrument
tissue response to, 125f Spinal trigeminal tract turning of, 509f
Silk sutures, 709 trigeminal nociceptive fibers of, 295f Streptococci
Silver alloy amalgam, 127128 Spiral obturation, 643 alpha-hemolytic
Silver amalgam restorations, 119120 Splints, 835 antibiotics for, 76
Silver nitrate, 138, 144, 264 Split tooth, 273274 Streptococcus anginosus, 78
PRODUCT INDEX
Page numbers followed by f indicate figures; page numbers followed by t indicate tables.
AH-26, 579, 583, 584, 586, 591, 592f, 631, Cleaning aids, 726f Enac ultrasonic device, 647
786 Clearfil, 584, 585f Enac ultrasonic spreader tips, 629f
AH-26 Silver-Free, 580 Clearfil New Bond, 640 Enac ultrasonic unit, 629
AH Plus, 583, 588, 631, 635 Co-Pilot, 521 Endex, 382f, 519, 520f
All Bond, 587 Col-Press, 715f Endo Access diamond stone, 406
Amalgambond, 266, 584, 651 Colitts solution, 369 Endo Analyzer, 519
Amalgambond Plus, 135136 CollaCote, 773, 778 Endo Analyzer 8005, 522
Anti-Ledging Tip file, 483 Collagen, 701 ENDO-BLOC, 382f
Apatite sealers, 656 Collastat OBP, 773 Endo-Gripper, 491
Apex Finder, 519 Combination Apex Locator and Endodontic Endo-M-BLoc, 512f
Apex Finder A.F.A., 521522, 521f Handpiece, 523 Endoanalyzer, 214
Apex locator, 491 Condensers, 708f Endodontic spoon excavator, 413f
Apexit, 580, 586 Contra-angle handpieces, 408f EndoExtractor, 647
Apical GP Plug Carrier, 638 Control Safe files, 483 Endomethasone, 580, 582, 588, 591, 593
Aseptico Electric Motor Handpiece, 491 Copalite, 134 Endoscope, 366f, 367f, 376
Ash-style forceps, 397398 Cosmopost, 929 Endotec II, 624, 625f
Aurafill, 146 Cotton pellets, 699 Endy 7000, 524
Cotton pliers, 677f Engine Plugger, 627
Barbed broach, 487f CRCS, 582, 616 ETM Electric torque control motor, 491
Bard Parker blade, 677f Currettes, 692f Exact-A-Pex, 519
Barrier, 134, 135, 584 Cutting blades, 473f
Bis-GMA, 137, 584 F speed, 360
Blue Micro Tip, 738f D-Liner, 135 Fault-Tolerant hard drives, 374
Bone curettes, 677f DE explorer, 677f Fermit, 650
Brasseler, 926, 929 DenOptix Storage Phosphor system, 371f Ferric sulfate, 700701
Brasseler GPX, 645f Densensitron, 265 Ferrules, 928f
Brasseler TLC, 626 Densfil, 575, 633, 637 FG burs, 693f
Burlew disks, 216, 273 Dental Advisor, 521 FG carbide burs, 677f
Burs, 677f, 693f, 702f Dentatus, 929 Fiberoptic headlamp system, 736f
Butler Proxabrush, 726f Dentin chip apical filling, 639 Fibrekor Post System, 929
DentinAdhesit, 584 File-Eze, 504, 532
C & B Metabond, 587, 652 Dentometer, 214 Fistulator, 585f
C-Post, 929 Dentsply, 583, 618 Flap retractors, 677f, 690f
Cadre Articule, 361, 396, 397f Dexon II, 710f Fletchers cement, 580
Calasept, 643 DG explorer, 506f Flex-R-file, 483, 492f, 537538
Calcioboitic Root Canal Sealer, 582, 616 Diaket, 580, 586, 588, 592f, 786 Flexi-Post, 929, 931f
Calxyl, 134 Digipex, 519 Flexobend, 482
Canal Finder System, 497, 646, 649 Digipex II, 214, 519 Flexofile, 480
Caries Detector, 148 Digitest, 214, 215f Flexogates, 485f
Carriers, 708f Duo Percha, 580 Fluori-Methane, 212, 263
Cavidry, 138 Durelon, 580 Formatron IV, 519
CaviEndo endodontic unit, 649 Dycal, 580, 586, 868 Formocresol, 268
Cavilax, 138 Dynatrak, 483 4-META, 128, 135136, 146, 266, 706
CaviLine, 135 Fuji glass ionomer, 580
Cavio-Endo, 647 E film, 360
Cavit, 126, 392, 580, 649, 650, 651, 705, Easy Flow, 629f, 631 Gates-Glidden burs, 631f, 926
773, 778 EDTA, 504 Gates-Glidden drills, 492f, 530, 537f, 541,
Cavitron Endodontic System, 494f EDTAC, 504 646, 782, 933f
Cavitron scaler, 628, 649 Electric torque control motor, 491 Gauze pads, 715f
Cerapost, 929 Electro Applicator, 265 Gelfoam, 701, 773
Chloropercha, 616f Electronic Apex Locators, 524 Gentle Pulse, 214
Root-end filling material carrier, 677f SPAD, 582, 593 Tooth Slooth, 216, 273, 273f
Root ZX, 522, 522f, 524 SPLIT-KIT, 382f Touch n Heat, 618, 618f, 625
Roth 801, 581, 586, 631 Spongostan, 701 Traitment SPAD, 588
Roth Sealer, 580 Stainless steel files, 480 Tri Auto ZX, 491, 523, 523f
Round-end carbide fissure bur, 406 Star VisiFrame, 361 Triflow syringe, 738f
Rubber dam retainer, 792f Starlite VisiFrame, 396 Trilite, 214
Stop attachment, 513f Triolon, 588
Safety Hedstrom file, 483, 484, 533 Stropko Irrigator, 738f TrioSonic, 496f
Savannah reamers, 926 Stropko irrigator, 618 Triple-Flex, 477, 533
Scaler, 677f Stropko syringe, 378 Trophy software, 373f
Scalpel blades, 686f Super EBA, 737f, 773 Tubli-Seal, 580, 582, 584, 585, 586, 588
Scissors, 677f, 717f Super Poli-Grip Denture Adhesive, 396 Tublicid, 146, 504
Scotchbond, 266, 584, 656 Surgical operating microscope, 737f
SealApex, 582, 583, 585, 586, 588, 591, Surgical telescopes, 736f U-file, 484
631, 635 Surgicel, 701 Ultra-Flex files, 484
SealApex EWT, 582 Suture materials, 709710, 710f Ultrasonic tips, 703f
SealApex Regular, 582 Suture removal kit, 717f Unifile, 483
Sealers, 786 Sutures, 677f Universal, 135
Sensodyne, 264 Sybron Endo, 582, 583 Urename, 146
SFOY ZX, 524
ShaperSonic, 496f Taper Rotary Instruments, 540541
Vicryl sutures, 710f
Shaping files, 544, 545f Telfa pads, 699f
Vitality Scanner, 214, 215f
SHP burs, 693f TempCanal, 643
Vitapex, 583, 586, 643
Silk sutures, 710f TERM, 392, 649, 650, 651
Vitrebond, 705
SimpliFill, 638, 638f, 639 TEXAS Case, 382f
VIXA intraoral sensor, 370f
SimpliFill syringe, 638 Thermadent, 264
Single sling suture, 686f ThermaFil, 575, 633, 634, 636, 637f
Sirotest, 214 ThermaFil plastic carrier, 635f Wachs cement, 582
Smear clean, 133 Thermal Lateral Condensation, 626 Wachs Sealer, 586, 615
SNAP, 129 ThermaPrep Plus oven, 635f
Snap-A-Ray holders, 373 ThermaSeal, 583, 635 Youngs frame, 396
Soft-Core, 633, 634, 635 ThermaSeal Plus, 583
Sonic Air Endo System, 495f Three Dee GP, 633, 634, 635 Zipperer Engine Plugger, 626
Sono-Explorer, 519 Time Line, 135 ZOE, 591, 593, 615
AUTHOR INDEX
Atasu M, 846, 858 Bammann LL, 78, 92, 872, 898 Bazzuchi M, 874, 899
Atkinson JS, 15, 16, 22 Banegas G, 524, 568 Beach CW, 524, 568
Attalla MN, 872, 898 Banes IE, 632, 665 Beagley KW, 178, 199
Aubin JE, 36, 57 Banett F, 759, 767 Beatty RG, 416, 559, 612, 615, 628, 647,
Augsburger RA, 107, 168, 212, 213, 257 Bang G, 698, 742 664, 665, 667, 696, 741
August DS, 107, 168, 759, 766 Baraban DJ, 922, 948 Beaver HA, 878, 899
Aurelio JA, 517, 566, 698, 742 Barailly R, 703, 742 Beck AT, 299, 350
Austin BP, 518, 520, 522, 567, 698, 701, Barata JS, 874, 899 Becker GL, 789, 793
741, 742 Baratieri A, 134, 171 Becking AG, 790, 794
Austin JC, 66, 88, 145, 146, 173 Barbakow FH, 517, 566, 746, 765 Beecher HK, 287, 349
Averbach RE, 595, 661 Barbanel RL, 37, 57 Beemster G, 400, 404
Averett JN, 791, 794 Barber J, 296, 350 BeGole EA, 518, 521, 567, 622, 664
Avery DR, 861, 862, 864, 868, 869, 896, Barber TS, 296, 350 Behr K, 513, 565
897 Barboni MG, 522, 523, 567 Behr M, 929, 931, 949, 950
Avery JK, 31, 36, 38, 41, 43, 51, 56, 57, 58, Barbosa CAM, 78, 92 Behrend GD, 634, 665
60, 873, 898 Barker BC, 889, 892, 901, 902 Behrman RE, 797, 841
Avillion G, 198, 201 Barkhordar RA, 74, 90, 178, 199, 200, 516, Bei M, 26, 27, 55
Aviv I, 920, 948 566, 580, 586, 587, 643, 650, Bekiroglu F, 690, 741
Avram DC, 881, 900 658, 659, 667, 707, 743, 926, Belanger GK, 864, 896
Axelrod P, 757, 764, 766, 768 949 Belenky M, 335, 355
Aylard S, 894, 902 Barkins W, 612, 663 Beling KL, 704, 742
Barnard D, 79, 92 Bell WE, 308, 314, 315, 320, 332, 334, 336,
B Barnes GW, 41, 53, 58 337, 351
Bab I, 853, 859 Barnes IE, 149, 173, 690, 740, 873, 898 Bell WH, 123, 169
Babal P, 74, 90, 178, 200 Barnett F, 50, 60, 69, 74, 90, 494, 497, Bellizzi R, 206, 213, 224, 225, 256, 257,
Baccetti T, 522, 523, 568 562, 563, 757, 759, 764, 766, 258, 417, 559, 675, 736, 739,
Bachman B, 27, 55 767, 768 745
Bachman CA, 537, 569 Baroja M, 178, 199 Beltes P, 584, 588, 597, 658, 660, 662
Bachman CE, 85, 93 Baron R, 289, 290, 333, 334, 336, 349, Ben Bassat Y, 829, 842
Bachmann L, 553, 570 354, 551, 570 Benatti O, 602, 603, 662
Bader JD, 801, 841 Barr ES, 891, 902 Bence R, 675, 740
Bae KS, 69, 89, 90 Barr JH, 360, 403 Bende I, 150, 173
Baek SH, 719, 744 Barrett AP, 334, 354 Bender IB, 35, 56, 64, 76, 78, 88, 91, 96,
Bagga BS, 83, 93 Barrett RJ, 833, 836, 842 102, 110, 115, 138, 149, 163,
Baggett FJ, 524, 568 Barron SL, 692, 741 164, 167, 168, 173, 174, 214,
BagnellC, 374, 403 Barrus BD, 888, 901 223, 257, 258, 358, 374, 403,
Bahcall JK, 377, 379, 404, 552, 570 Barss JT, 379, 404 729, 745, 785, 793, 812, 842,
Bahn A, 868, 897 Barthel CR, 650, 668 862, 865, 870, 872, 896, 908,
Bahra A, 324, 352 Bartlett SO, 922, 948 912
Bahram J, 266, 286 Bartoshuk LM, 348, 356 Benenr MD, 612, 663
Bailey B, 21, 23 Basbaum AI, 289, 349 Benn DK, 375, 403
Bailit H, 4, 21 Basbaum AJ, 291, 296, 350 Bennett CR, 679, 740
Baisden MK, 416, 559 Basten CHJ, 727, 744 Benoit PW, 345, 356
Baker MC, 494, 562 Batchelder BJ, 317, 352 Benoliel R, 324, 352
Baker PT, 74, 75, 91 Bates B, 305, 351 Benson BW, 516, 566
Baker W, 359, 403 Bates CF, 706, 743 Bentkover SK, 690, 741
Bakland LK, 141, 172, 176, 177, 178, 182, Bates RE, 347, 356 Benz C, 371, 403
199, 200, 579, 657, 786, 793, Batista MM, 499, 563 Benzer G, 863, 896
796, 804, 808, 840, 841, 843 Battrum DE, 690, 741 Berastegui F, 628, 665
Bal CS, 516, 566 Bauer B, 325, 353 Berastegui J, 474, 488, 560, 561
Balawi S, 346, 347, 356 Baumann L, 358, 403 Berbert A, 510, 517, 564, 922, 948
Balawi SA, 347, 356 Baume LJ, 32, 34, 56, 145, 149, 173, 639, Berdmore T, 727, 744
Balbachan I, 607, 663 666, 870, 897 Berg B, 525, 568, 623, 664
Balbuena L, 329, 330, 353 Baumgardner KR, 606, 629, 662, 665 Berg JO, 396, 404
Balekjian AY, 499, 563 Baumgartner JC, 15, 22, 64, 67, 69, 74, 76, Berg MS, 505, 564
Balestrieri F, 679, 740 77, 78, 88, 89, 90, 91, 485, Bergenholtz G, 34, 48, 50, 56, 59, 60, 66,
Balikov S, 795, 840 497, 499, 500, 501, 503, 505, 69, 74, 88, 90, 97, 155, 157,
Ball KA, 376, 404 540, 548, 549, 561, 563, 564, 167, 174, 176, 186, 198, 200,
Ballener JJ, 310, 351 569, 704, 742 646, 667, 670, 727, 739, 744,
Balling R, 26, 55 Baumhammers A, 701, 742 761, 767, 870, 873, 897, 898,
Bamberger N, 854, 859 Bavitz JB, 285, 286 915, 947
Berger JE, 864, 876, 877, 896, 899 Blair GS, 716, 744 Bramante CM, 510, 517, 564
Bergman B, 916, 917, 947 Bland JH, 319, 352 Bramwell JD, 396, 404, 524, 568, 584, 658
Berk H, 153, 174, 883, 884, 900 Blaney TD, 79, 92, 650, 667 Brandebura J, 105, 106, 168
Berkoff GM, 339, 340, 355 Blankenship J, 177, 199 Brandell DW, 640, 666
Berlin J, 77, 91 Blanshard JMV, 575, 657 Brandt KD, 314, 351
Berman LH, 516, 566 Blaukopf ER, 922, 948 Branemark PI, 732, 745
Bernick S, 37, 40, 41, 43, 46, 53, 57, 58, Blayney JR, 574, 657 Brannon RB, 189, 201
862, 863, 886, 896, 901 Blinkhorn FA, 799, 841 Brannstrom M, 25, 36, 37, 48, 49, 51, 55,
Bernier JL, 122, 169, 865, 896 Block RM, 579, 586, 593, 646, 657, 659, 56, 57, 59, 61, 96, 102, 115,
Bernier WE, 79, 92, 580, 658, 923, 926, 661, 667 118, 132, 133, 145, 149, 167,
949 Blomlof L, 55, 61, 727, 744, 837, 838, 169, 171, 173, 260, 261, 262,
Bernstein E, 886, 901 839, 843, 904, 912 264, 285, 388, 404, 802, 841
Bernstein M, 512, 565 Bloom GD, 65, 69, 88 Branstetter J, 586, 659
Berry EA, 504, 564 Blosser RL, 137, 172 Brantley WA, 479, 486, 492, 560, 561, 562
Berry HM, 357, 403 Blum JY, 542, 569, 608, 617, 663, 664 Brau AE, 488, 561
Berry KA, 606, 662 Blumenshine R, 146, 173 Brau-Aguade E, 628, 665
Berset GP, 761, 767 Boas RA, 334, 354 Braun RJ, 115, 168
Berson RB, 884, 900 Bobotis HG, 79, 92, 392, 404, 650, 667 Bray GM, 335, 355
Berthold CE, 911, 912 Bodal CF, 791, 794 Brayton SM, 492, 561, 572, 656
Bertolini DR, 178, 199 Bodecker CF, 138, 172 Bremer M, 519, 567
Bertolotti RL, 133, 147, 171, 173 Boering G, 315, 351 Brewer AA, 945, 950
Bertrand G, 703, 742 Bogduc N, 320, 352 Brian JD, 790, 794
Berutti E, 781, 792 Bogen G, 74, 90, 759, 766 Bricker SL, 516, 565
Besner E, 698, 742 Bogetto F, 348, 356 Briedigketi H, 650, 668
Bessem C, 28, 56 Boggs WS, 699, 742 Briggs PFA, 494, 562
Bettes P, 394, 404 Bohannan HM, 7, 22, 121, 169, 555, 570 Brilliant JD, 492, 502, 561, 564, 779, 792
Bevelander G, 44, 58 Bolanos OR, 496, 563, 597, 662 Brin I, 829, 842
Bevelander S, 863, 896 Bolden TE, 206, 256 Bringas P, 28, 56
Beveridge EE, 50, 60, 260, 262, 263, 266, Boles R, 284, 286 Bringman TS, 178, 199
285, 368, 403 Bolger WL, 484, 561 Briscoe WT, 138, 172
Beydoun A, 334, 354 Boling LR, 38, 57, 67, 89, 110, 168 Briseno BM, 485, 486, 561, 587, 588, 660
Beyer-Olsen EM, 580, 658 Bonaccorso A, 550, 569 Brodin E, 50, 60
Bhakdinarenk A, 516, 565 Bond MS, 624, 631, 664, 665 Brodin P, 595, 661, 786, 793
Bhaskar SN, 11, 22, 25, 28, 38, 46, 53, 55, Bonica JJ, 317, 352 Broggi G, 331, 354
57, 104, 168, 181, 187, 200, Boniface M, 759, 767 Brondum K, 926, 928, 929, 949
201, 512, 565, 873, 898 Bonin P, 122, 169 Brook AH, 889, 902
Bhat KS, 789, 790, 793 Bonzales F, 36, 57 Brook AM, 587, 659
Bhatia HD, 876, 899 Boraas JC, 484, 561 Brook I, 68, 69, 89, 90
Bibel D, 65, 88 Borden BG, 499, 563 Brooke RI, 284, 286
Bier SJ, 719, 744 Borer RF, 852, 859 Brooks JK, 140, 172
Biesterfeld RC, 49, 59, 103, 104, 150, 168, Borglum-Jensen S, 678, 740 Brooks LE, 143, 172
173, 209, 217, 256, 257 Borin M, 587, 659 Brosch JW, 873, 898
Biggs JT, 587, 660, 779, 792 Borum MK, 818, 820, 829, 842 Brose MO, 915, 947
Bilkay U, 597, 662 Boskman L, 847, 858 Brothman P, 612, 663
Billiau A, 178, 199 Bossmann K, 79, 92, 580, 658 Broton JG, 292, 296, 350
Bimstein CD, 884, 900 Bou Dagher F, 581, 658 Brough KM, 266, 286
Bimstein E, 878, 900 Boucher Y, 254, 258 Brough SO, 573, 586, 656, 659
Bingham JAE, 335, 354 Bouillaguets S, 50, 60 Broweleit D, 616, 664
Birt D, 284, 286, 309, 351 Bouquot JE, 194, 198, 201, 329, 353 Brown AC, 50, 60, 262, 266, 285
Bissad NF, 262, 285 Bourgeois RS, 644, 666, 925, 949 Brown CE, 78, 91, 516, 565, 566, 655,
Bitenski A, 920, 948 Bowen RL, 129, 137, 170, 172 668, 670, 704, 739, 742
Bittar G, 324, 352 Bowers DE, 857, 859 Brown JA, 516, 565
Bitter NC, 850, 856, 858 Bowsher D, 333, 354 Brown JI, 505, 564
Bjertness E, 761, 767 Boyd A, 597, 662 Brown WE, 585, 659, 883, 900
Bjonrdal AM, 416, 559 Boyd J, 796, 819, 841 Browne RM, 102, 124, 131, 145, 167, 170,
Bjorenson JE, 698, 741 Boyd L, 49, 59 171, 173, 580, 589, 658, 660
Bjorndahl A, 48, 51, 59, 514, 565, 697, Boyes-Varley JG, 700, 742 Brozman M, 74, 90, 178, 200
741 Boyne PH, 187, 200, 690, 741, 840, 843 Bruehl S, 335, 354, 355
Bjorvaten K, 870, 872, 897 Bradford EW, 866, 896 Brunski JB, 733, 745
Black GV, 138, 172, 405, 471, 558, 865, 896 Bradshaw GB, 612, 632, 633, 663 Bruyn GW, 331, 354
Black RG, 43, 58 Brady JM, 505, 564, 578, 657 Bryant ST, 483, 540, 541, 560, 569
Brynolf I, 221, 257, 375, 404, 756, 759, Calt S, 598, 662 Chacker F, 727, 744
766, 767 Calzonetti KJ, 704, 742 Chai Y, 26, 27, 28, 55
Buchanan LS, 480, 501, 509, 525, 526, Cambruzzi JV, 690, 697, 741 Chalfin H, 719, 744
527, 528, 530, 560, 564, 568, Cameron CE, 212, 256 Chambers TJ, 178, 199
623, 664, 736, 745, 785, 793 Cameron JA, 494, 501, 562, 564 Chan K, 417, 559
Buchel C, 324, 352 Camp JH, 871, 889, 891, 894, 897, 902 Chan NC, 516, 565
Bucher JF, 530, 568 Camp LR, 923, 948 Chance K, 107, 168
Buckley JP, 876, 899 Campbell AW, 333, 354 Chandler G, 915, 947
Buckley M, 761, 767 Campbell D, 524, 568 Chandler NP, 78, 92, 580, 658, 692, 741,
Buczko W, 47, 58 Campbell JK, 331, 354 764, 768
Budd CS, 627, 633, 663 Campbell RL, 275, 286 Chandra S, 588, 660
Buehler WJ, 486, 561 Camps JJ, 576, 657 Chang JW, 331, 354
Buerschen GH, 491, 561 Canalda-Sahli C, 474, 488, 560, 561, 586, Changsheng L, 654, 668
Buhler H, 727, 744 628, 659, 665 Chapman CE, 511, 565
Bujanda-Wagner S, 759, 767 Canavan D, 334, 354 Chapman KA, 573, 656
Bullard A, 82, 93 Canby CP, 102, 167, 865, 896 Chapman LF, 289, 349
Bullard RH, 147, 173 Canfield RB, 43, 58 Charles JE, 539, 569
Bullock W, 194, 201 Cankaya H, 759, 766 Charles TJ, 539, 569
Buranadham S, 922, 948 Cannon CR, 319, 352 Chaudhary M, 516, 566
Burch BS, 499, 563 Cappabianca P, 331, 354 Chaumette MT, 122, 169
Burch JG, 511, 565 Cappuccino CC, 31, 56 Chaunch HH, 129, 170
Burch JH, 30, 56 Caputo AA, 129, 146, 170, 920, 923, 926, Chaung HM, 875, 899
Burchiel KJ, 331, 332, 354 948, 949 Chen JT, 339, 355
Burfke SH, 579, 657 Cardella P, 36, 57 Chen SM, 339, 355
Burger C, 359, 403 Carlee AW, 68, 69, 89 Chen YN, 26, 55, 338, 355, 719, 744
Burgess JO, 4, 21, 136, 172, 854, 859 Carlo GT, 265, 286 Chenail BL, 494, 562, 645, 667, 698, 742,
Burgess LW, 852, 859 Carlson CR, 338, 343, 355 782, 793
Burghardt SF, 554, 570 Carlsson AP, 707, 743 Cheng TMW, 330, 353
Burke RS, 30, 56 Carlsson GE, 314, 351 Chernick LB, 480, 560
Burnell SC, 922, 948 Carlsson J, 65, 88 Chernow B, 679, 740
Burnett GW, 102, 167 Carmeron JA, 494, 562 Cherrick H, 194, 201
Burns JM, 5, 22 Carmichael DJ, 873, 898 Cherry DV, 857, 859
Burns RC, 3, 5, 21, 496, 562 Carnes DL, 540, 548, 569, 639, 666, 706, Chestner SB, 579, 657
Burns TB, 709, 743 743 Cheung GS, 675, 740
Burrell W, 892, 902 Carnes PL, 911, 912 Chiappinelli J, 74, 75, 91
Burton DJ, 105, 106, 168 Carnevale G, 727, 744 Chien S, 50, 60
Buttler TK, 500, 563 Carr GB, 690, 736, 741, 745 Chimenti R, 759, 767
Byers MR, 41, 42, 43, 47, 51, 58, 59, 176, Carranza FA, 110, 168 Chisholm K, 347, 356
198 Carter JM, 915, 947 Chisolm EC, 587, 659
Bynum JW, 181, 200 Casamassimo PS, 329, 353 Chisty JM, 922, 948
Bystrom A, 67, 68, 77, 78, 89, 91, 92, 499, Casanova F, 616, 617, 664 Chivian N, 232, 258, 807, 841
500, 563, 757, 759, 766, 829, Cascino TL, 330, 353 Chohayeb AA, 137, 172, 587, 601, 612,
842 Casey LJ, 854, 859 654, 659, 662, 663, 668
Casper JS, 891, 902 Chong BS, 705, 742
C Cassel RD, 331, 354 Chong R, 52, 61, 593, 661
Cabrera P, 926, 949 Castelli WA, 625, 665, 680, 740 Chosack A, 871, 897
Cabrini RL, 588, 660 Castello VU, 516, 566 Chow LC, 585, 586, 587, 643, 653, 659
Caen JP, 701, 742 Castelucci A, 518, 522, 567 Chow TW, 502, 564
Cahn SA, 593, 661 Cavallari J, 920, 923, 928, 948 Christ T, 196, 201
Caicedo R, 582, 658 Cavataio RE, 518, 567 Christian CL, 314, 351
Cailleteau JG, 214, 257, 472, 559 Cavelleri G, 519, 521, 567 Christian J, 329, 353
Cain C, 519, 525, 567 Cecchini SCM, 553, 570 Christiansen EL, 840, 843
Cain CW, 625, 665 Cecic PA, 206, 256, 503, 564 Christiansen RK, 548, 549, 569
Calamia J, 266, 286 Cederberg RA, 516, 566 Christiansen RL, 50, 60
Calderwood RG, 690, 741 Celleti R, 722, 744 Christie WH, 522, 567, 779, 792
Caldwell JJ, 512, 565 Cengiz T, 78, 91, 505, 564 Chu CS, 916, 947
Cale A, 195, 201 Cerneux M, 598, 662 Chung JM, 335, 355
Calhoun G, 485, 561 Cerqueira MD, 577, 657 Chung K, 335, 355
Calhoun RL, 15, 16, 22 Cervero F, 290, 350 Chung KH, 335, 355, 916, 947
Callahan JR, 612, 613, 664 Cervone F, 759, 766 Chung SS, 331, 354
Calleteau JG, 512, 565 Ceuppens J, 178, 199 Chunn CB, 518, 567
Cioni B, 331, 354 Cotti E, 177, 199 Dachi SF, 188, 201, 212, 257
Cirnis GJ, 485, 561 Cotton WR, 78, 91, 133, 149, 171, 173, Dagher FB, 619, 664
Cirspin BJ, 129, 170 870, 872, 897 Dahl BL, 131, 171
Ciucchi B, 50, 60 Cottone JA, 114, 168 Dahl E, 38, 40, 41, 43, 57, 58
Civechi B, 597, 598, 662 Courts FJ, 871, 872, 886, 897, 898, 901 Dahlen G, 50, 60, 67, 68, 74, 78, 89, 175,
Civjan S, 486, 561 Cousins MJ, 347, 356 198, 764, 768
Claesson R, 78, 92, 829, 842 Cow E, 651, 668 Dahlgren U, 69, 90
Clagett J, 177, 178, 199 Cowley G, 684, 740 Dahlstrom SW, 852, 859
Clarich JD, 316, 351 Cox CF, 133, 136, 171, 172, 808, 841, 862, Dajani AS, 76, 91, 908, 912
Clark CA, 362, 403 870, 871, 873, 874, 896, 897, Dalat DM, 584, 658
Clark GE, 517, 566 898, 899 Dale I, 324, 352
Clark GT, 304, 320, 351 Cox VS, 516, 565 Dalessio DJ, 310, 323, 324, 326, 351, 352,
Clarke NG, 66, 88 Craig KR, 707, 743 353
Clausen H, 366, 403 Craig PH, 710, 744 Damele J, 864, 869, 896
Cleary PT, 601, 662 Craig RG, 48, 59, 920, 923, 948 Damm D, 194, 198, 201
Cleaton-Jones PE, 66, 88, 700, 742 Crane DL, 582, 658 Dandekar R, 320, 352
Clement DJ, 540, 548, 569, 605, 662 Crawford JJ, 79, 81, 83, 84, 85, 92, 93, Danforth R, 709, 743
Cleveland E, 500, 563 500, 563 Dang DA, 607, 663
Clouse HR, 516, 566 Creech JL, 275, 286 Daniels T, 155, 174
Cobb EN, 137, 172 Creugers NHJ, 916, 917, 947 Dankert J, 885, 901
Coccia CT, 838, 839, 843 Crim GA, 850, 859 Dannenberg JL, 875, 899
Codben RH, 700, 742 Crona-Larson G, 799, 822, 841, 842 Darzenta N, 358, 403
Coffey CT, 48, 51, 59 Crook JH, 692, 741 Das S, 577, 657
Cohen BD, 406, 559, 576, 657 Crowley MC, 11, 22, 698, 742, 868, 897 Daublander M, 679, 740
Cohen BI, 920, 948 Crum LA, 494, 562 Davarpanah M, 722, 744
Cohen G, 32, 56, 115, 169 Crump MC, 11, 22, 256, 258, 753, 766, Davenport RE, 679, 740
Cohen JB, 554, 570 784, 793 Davey KW, 802, 804, 841
Cohen S, 17, 18, 19, 22, 52, 61, 221, 257, Cuenin PR, 77, 91, 497, 563 Davids LL, 69, 89, 90
496, 562, 595, 661, 673, 739, Cuicchi B, 530, 568 Davies AL, 214, 257
847, 852, 855, 858, 859 Cullen CL, 891, 902 Davies J, 79, 92
Cohen SC, 855, 859 Cummings RR, 690, 693, 741 Davis JM, 887, 901
Cohen SR, 211, 256 Cunningham CJ, 179, 200 Davis JR, 690, 741
Cohen T, 573, 586, 656, 659 Cunningham KW, 254, 258 Davis KD, 291, 296, 350
Cohenca C, 18, 23, 787, 793 Cunningham WT, 78, 91, 376, 404, 494, Davis KW, 710, 744
Cohler CM, 593, 661 499, 562, 563 Davis M, 886, 901
Coll JA, 868, 878, 889, 892, 895, 897, 902 Curgon ME, 891, 902 Davis SR, 572, 656
Collard EW, 920, 948 Curley A, 21, 23 Davis WL, 680, 716, 740, 744
Collett WK, 670, 739 Curson I, 586, 659 Davy DT, 920, 923, 948
Collins F, 27, 55 Curtis RV, 491, 561 Dayoub MB, 86, 93
Collinson DM, 494, 562 Cury JA, 597, 662 Dazey SE, 75, 91
Colls JA, 891, 902 Custer LE, 517, 566 De Cleen MJH, 761, 767
Combe EC, 923, 926, 949 Cutcher JL, 710, 744 De Gee A, 584, 658
Combie ED, 576, 657 Cutler CW, 634, 665 De Graaff J, 68, 69, 89, 90, 759, 767
Compton CP, 795, 841 Cutright DE, 38, 53, 57, 680, 740 De La Rosa VM, 179, 200
Conklin WW, 105, 106, 168 Cvek J, 652, 653, 668 De Renzis FA, 707, 743
Conroy CW, 50, 60 Cvek M, 66, 78, 79, 88, 91, 92, 151, 165, De Souza FJ, 143, 172
Cook B, 911, 912 173, 174, 804, 808, 818, 820, De Souza V, 759, 766
Cooke HG, 114, 168, 505, 564 824, 827, 836, 841, 842, 843, De Uzeda M, 78, 92, 499, 563
Cooley RL, 108, 168, 212, 213, 214, 257, 852, 853, 859, 871, 897 De Vincente JC, 722, 744
264, 285, 727, 744 Cwyk F, 236, 238, 258 DeAlmeida OP, 143, 172
Coolidge ED, 29, 56, 652, 653, 668 Cymerman DH, 74, 90, 178, 200 Dean JA, 888, 901
Cooper IR, 131, 171 Cymerman JJ, 74, 90, 178, 200 Dean JP, 929, 949
Coppola S, 616, 664 Cyr G, 143, 144, 172 Debelian GF, 64, 76, 88
Corbett MD, 151, 157, 173, 863, 896 Czarnecki RT, 66, 88 Debelian GJ, 762, 768
Corcoran JF, 374, 403, 525, 568, 696, 741, Czernicki Z, 330, 353 DeBigontina P, 342, 355
922, 948 Czerniejewski W, 359, 403 DeBont LGM, 315, 351
Corey SE, 911, 912 Czerw RJ, 517, 522, 566, 567 DeCastro RA, 675, 739
Cormier CJ, 474, 560 Czonstkowsky M, 573, 612, 656, 664 Deck JH, 333, 354
Corpier CL, 906, 912 Dederich DN, 551, 569
Costa CAS, 874, 899 D DeDeus QD, 52, 61
Costa L, 925, 929, 949 da Silva CH, 577, 657, 929, 949, 950 Dedik J, 212, 213, 257
Deeb E, 727, 744 DiMaggio JJ, 864, 896 549, 560, 561, 562, 565, 569
Deemer JP, 589, 660 Dinin PA, 15, 16, 22 Dummett CO, 892, 902
Del Rio CE, 179, 200, 491, 497, 501, 505, Dionne RA, 911, 912 Dumsha TC, 573, 585, 656, 659, 776, 792,
540, 548, 549, 561, 563, 564, Dippel HW, 49, 59 822, 827, 842
569, 578, 657, 669, 706, 739, Dirksen TR, 52, 61 Duncan JM, 790, 794
743, 793 Dixon CM, 581, 658 Dunkelberger FB, 244, 258
Delano EO, 16, 22 Dobbs JL, 524, 568 Dunlap GA, 518, 521, 567
Delassio DJ, 325, 353 Doblecki W, 587, 659 Dunn JT, 176, 199
DelBalso AM, 50, 60 Dodds RN, 670, 739 Dunsky J, 716, 744
Delcanho RE, 324, 352 Dodick DW, 324, 352 Durack D, 77, 91
Delhom JJ, 400, 404 Doering JV, 264, 266, 285 Durgun B, 709, 744
Deli R, 134, 171 Dom RM, 316, 351 Dwyer TG, 65, 88, 926, 949
Delivanis PD, 67, 89, 557, 570, 573, 586, Dominguez FV, 589, 660 Dziak R, 178, 199
656, 659, 923, 926, 949 Donado JE, 400, 404
Dellinger TM, 847, 858 Donley DL, 632, 665 E
Demirci T, 68, 78, 89 Donnelly JC, 360, 403, 517, 522, 566, 567 Eames WB, 134, 171
Dempster WT, 416, 559 Donta-Bakoyianni C, 189, 201 Easlick K, 63, 88
Denny-Brown D, 333, 354 Dooley BS, 922, 948 Ebert JR, 710, 744
Denry I, 850, 856, 858 Doran JE, 505, 564 Ebihara A, 694, 741
Dent D, 198, 201 Dorfman A, 102, 167, 865, 896 Eby WC, 176, 198
DeNys M, 645, 666 Dorman H, 138, 172 Eckerbom MI, 69, 90, 516, 565, 761, 767,
Depew DD, 134, 171 Dorn SO, 705, 706, 707, 742, 743 916, 921, 947
DeRenzis F, 577, 657 Dorney B, 795, 840 Economides N, 584, 588, 597, 658, 660,
DeSimon LB, 486, 561 Dorscher-Kim J, 39, 57 662
Desousa YG, 74, 90 Doughterty W, 69, 89 Edmeads V, 319, 320, 352
DeSouza V, 652, 653, 668 Douglas WH, 915, 947 Edmonds DH, 637, 666
DeStafano F, 64, 88 Douglass CW, 96, 167 Edwall B, 50, 51, 60
Detakats G, 335, 355 Dove SB, 516, 540, 548, 549, 566, 569, Edwall L, 36, 41, 43, 50, 51, 56, 58, 60
Detsch S, 376, 404 605, 662 Eftimiadi C, 65, 88
Detusch AS, 920, 948 Dove SG, 548, 569 Egermark I, 314, 351
Deutsch AS, 920, 923, 928, 948 Dow PR, 571, 656 Eggink CO, 748, 751, 766
Deveaux E, 79, 92, 649, 650, 667 Dowden WE, 66, 78, 88, 92, 110, 129, Ehrenreich DV, 868, 897
Devin MJ, 86, 93 133, 148, 168, 170, 173 Ehrich DG, 790, 794, 911, 912
DeVitre R, 49, 59 Dowson J, 223, 257 Ehrlich AD, 496, 563
Devor M, 295, 331, 335, 350, 354, 355 Doyle RJ, 67, 89 Ehrman EH, 212, 213, 257, 595, 661
Devoto FC, 895, 902 Doyle WA, 876, 877, 899 Eick JD, 147, 173
Dewey KW, 40, 57 Dragani L, 342, 355 Eidelman E, 864, 868, 869, 871, 896, 897
Dewhirst RB, 922, 948 Dragoo MR, 778, 792 Eisenmann DR, 35, 56
Dezan E, 577, 657 Drahein R, 872, 898 Eitman T, 874, 899
Dheerendra P, 331, 354 Drake D, 651, 668 Ekbom A, 39, 57
DHoore W, 670, 675, 739, 740 Dreizen S, 74, 90 Ekbom K, 325, 353
Dhuru VB, 520, 522, 567 Driscoll WS, 847, 852, 858 El-Attar A, 840, 843
di Fego G, 727, 744 Droter JA, 894, 902 El Deeb ME, 484, 497, 561, 563, 573, 584,
Di Fiore PM, 359, 377, 403, 404, 652, Drucker D, 67, 68, 69, 89 587, 612, 633, 639, 647, 655,
668, 791, 794 Druigan MC, 330, 354 656, 659, 663, 666, 667, 773,
Di Padova FE, 178, 199 Druttman ACS, 501, 502, 564 792
Di S, 123, 169 Dryden JA, 15, 22, 729, 744 El-Kafrawy AH, 124, 129, 170
Diamond S, 323, 324, 326, 334, 352, 353, DSilva NJ, 196, 201 el-Swiah JM, 693, 741
354 DSouza R, 74, 77, 91, 178, 199 El-Tagouri H, 505, 564
Diangelis AJ, 803, 841 Dubeck JM, 903, 912 Eleazer KR, 15, 22, 416, 559
Diaz-Arnold A, 651, 668, 854, 859 Dubner R, 290, 350 Eleazer PD, 15, 22, 416, 559, 781, 793,
Dick HM, 873, 898 Dubrow H, 639, 666 911, 912
Dick W, 679, 740 Dubuisson D, 329, 353 Eley BM, 141, 172
Dickenson AH, 290, 350 Duddles RS, 416, 559 Elfenbein L, 751, 766
Dickey DJ, 644, 666, 926, 949 Duell RC, 216, 257 Elford P, 178, 199
Dickey DM, 129, 170 Duffy VB, 348, 356 Eliades G, 597, 662
Diekwisch T, 26, 27, 55 Dugal MS, 891, 902 Eliasson S, 238, 258, 916, 917, 947
Dietz G, 19, 23 Duguid R, 78, 92, 580, 658 Eling B, 394, 404
Dihn Q, 492, 561 Duke ES, 146, 173 Eliott JA, 675, 739
Dilley GL, 920, 923, 948 Dummer PMH, 214, 257, 483, 485, 496, Ellingsen MA, 516, 566
Dilly G, 886, 901 511, 514, 540, 541, 546, 548, Elliott LM, 491, 561
Ellis GE, 802, 840, 841, 843 Falchetta M, 518, 522, 567 Fischer R, 500, 563
Ellison RL, 696, 741 Falkler WA, 67, 69, 74, 89, 90 Fish EW, 47, 59, 63, 88, 163, 174, 186, 200,
Ely EW, 690, 741 Falkler WAJ, 69, 90 232, 258, 692, 741, 922, 948
Emery G, 38, 57, 299, 350 Falomo OO, 690, 741 Fishbain DA, 304, 337, 351
Emling RC, 177, 179, 199 Fan B, 926, 949 Fishel D, 511, 565
Emmerson CC, 876, 899 Fan VSC, 67, 89, 557, 570 Fishelberg G, 225, 258, 416, 559
Enberg K, 65, 69, 88 Fanibunda KB, 595, 596, 661 Fisher AK, 49, 50, 59
Engel D, 177, 178, 199 Faraco IM, 808, 841 Fisher FJ, 872, 898
Engelman MJ, 920, 926, 927, 948, 949 Farah JW, 920, 923, 948 Fishman SA, 888, 901
England MC, 143, 172, 270, 286, 593, Farber JL, 165, 174 Fiskio HM, 882, 900
661, 773, 779, 792 Farber JP, 512, 565 Fitzgerald GM, 359, 403
Englander HR, 163, 174 Farbet PA, 707, 743 Fitzgerald M, 130, 132, 170, 171
Engstrom B, 78, 91, 785, 793 Farik B, 803, 841 Fitzgerald RJ, 65, 77, 88, 175, 757, 766,
Engstrom G, 78, 91 Farman A, 359, 403 870, 897, 903, 912
Ennis LM, 357, 403 Farnoush A, 35, 56 Fitzpatrick EL, 708, 743
Enstrom B, 499, 563, 761, 767 Farrants G, 374, 403 Flath RK, 274, 275, 286
Epker BN, 595, 661 Fauchard P, 147, 173, 727, 744, 913, 914, Flatz CM, 892, 902
Epstein JB, 81, 92, 348, 356, 395, 404 947 Fleischman SB, 516, 566
Epstein R, 198, 201 Faus VA, 628, 665 Fogel BA, 643, 666
Erausquin J, 589, 591, 641, 660, 666, 895, Fava L, 15, 22 Fogel H, 49, 59
902 Fava LRG, 583, 658, 775, 792 Folio J, 129, 170
Ercalik S, 846, 858 Fay T, 318, 352 Folleras T, 146, 173
Erdelsky I, 212, 213, 257 Fearnhead RW, 43, 58 Fong CD, 28, 55
Erdilek N, 583, 658 Featherstone JDB, 551, 569 Fonzi L, 178, 199
Eriksen HM, 133, 171, 670, 739, 761, 762, Febo GD, 727, 744 Forabosco A, 348, 356
767 Fedoy G, 781, 792 Ford KT, 325, 353
Eriksson AR, 632, 665, 690, 691, 741 Fehr F, 504, 564 Ford RG, 325, 353
Eriksson L, 709, 743 Fei AL, 887, 901 Fordyce WE, 307, 351
Erisen R, 595, 661 Feigal J, 588, 660 Foreman DW, 30, 56
Erodos EG, 176, 199 Feiglin B, 40, 52, 58, 61, 587, 660, 916, Foreman PC, 43, 58, 149, 173, 524, 568,
Erpenstein H, 727, 744 947 595, 661
Esberard M, 478, 560 Feinmann C, 346, 347, 356 Fors UGH, 85, 93, 396, 404, 628, 665
Escavy JT, 576, 657 Feit J, 149, 173 Forsberg JA, 179, 200, 359, 403, 516, 520,
Eschen S, 746, 765 Feldman HJ, 647, 667 565, 567
Eshelman EG, 915, 947 Felippe MCS, 520, 567 Forsell-Ahlberg K, 36, 56
Eskoz N, 518, 567 Fellingeret E, 40, 41, 57 Forte SG, 708, 743
Estrela C, 78, 92, 872, 898 Felt-kamp-Vroom T, 78, 91 Foster JK, 358, 403
Ether S, 15, 16, 22 Felt RA, 482, 492, 560, 562 Foster KH, 78, 92
Ether SS, 588, 660 Felton DA, 121, 169, 914, 947 Fottohi K, 916, 947
Etikan I, 589, 660 Ferguson DD, 679, 740 Fouad AF, 74, 75, 91, 178, 179, 187, 199,
Eto JN, 553, 570 Ferrari M, 584, 587, 659 201, 517, 518, 520, 524, 525,
Evans AW, 788, 793 Ferrillo PJ, 790, 794 529, 566, 567, 568
Evans JA, 335, 354 Ferro G, 348, 356 Fowler CB, 69, 74, 90, 759, 766
Evans RT, 74, 75, 91, 572, 586, 656, 659 Ferroli P, 331, 354 Fowlwaczny M, 551, 570
Evanson L, 225, 258 Fertik G, 64, 88 Fox AG, 862, 896
EvansRJ, 333, 354 Festal F, 703, 742 Fox JL, 15, 16, 22, 784, 793
Everett F, 107, 168 Feyen JHM, 178, 199 Fraga RC, 499, 563
Evers S, 325, 353 Fiedler DE, 181, 200 Francica F, 330, 353
Eversole LR, 238, 258 Fields HL, 287, 289, 290, 291, 292, 296, Frank AL, 108, 141, 168, 172, 232, 235,
Ewart A, 625, 665 335, 336, 349, 350 258, 669, 675, 690, 693, 732,
Ewoldsen NO, 705, 742 Figdor D, 68, 78, 79, 89, 92, 764, 768 739, 741, 745, 756, 757, 759,
Filho IB, 478, 560 766, 779, 781, 792
F Filho JJ, 143, 172 Frank RM, 32, 36, 40, 41, 43, 51, 56, 57,
Fabiana CP, 872, 898 Filippi A, 837, 843 58
Fabra-Campos H, 637, 666 Fine H, 510, 564 Frankl SH, 863, 871, 884, 885, 896, 898,
Fabricius L, 67, 74, 89, 175, 198 Finkelman RD, 176, 198 901
Fadhavi S, 876, 888, 899 Finley K, 520, 567 Frankl Z, 593, 661
Fager FK, 52, 61 Finn MD, 698, 701, 742 Franzblau Z, 178, 199
Fahid A, 416, 559, 623, 664 Finn SB, 861, 862, 870, 875, 896 Franzina A, 331, 354
Fairbourn DR, 497, 563, 867, 897 Fiore-Donno G, 145, 173 Fraser JG, 532, 568
Falace DA, 338, 343, 355 Fischer EJ, 625, 633, 663, 706, 743 Frazier EH, 68, 69, 89, 90
Freccia WF, 845, 854, 858, 859 Garber DA, 856, 859 Gibbs C, 68, 69, 89
Frederikse NL, 516, 566 Garberoglio R, 36, 48, 57, 59 Gibbs M, 575, 657
Fredriksson M, 929, 949 Garces-Ortiz M, 584, 658 Gibilisco F, 197, 201
Freedland JB, 812, 842 Garcia AA, 516, 566 Gibilisco J, 251, 258
Freidman S, 518, 567 Garcia AM, 722, 744 Gier RE, 67, 88
Friction JR, 304, 311, 314, 336, 342, 346, Garcia-Godoy F, 132, 171, 873, 874, 878, Gigoux C, 479, 560, 577, 657
351, 355, 356 879, 886, 892, 898, 899, 900, Gil J, 852, 859
Friedlander AH, 326, 353 901, 902 Gilbert BO, 646, 649, 667
Friedman CE, 576, 655, 657, 668, 781, Garcia J, 572, 656 Gilles JA, 650, 667
793 Gardner DE, 873, 898 Gillis R, 416, 559
Friedman I, 762, 768 Garfunkel A, 149, 173 Gilmore H, 151, 173
Friedman S, 122, 123, 169, 394, 404, 524, Garlipp O, 577, 657 Gilmore HW, 124, 170
568, 584, 646, 650, 652, 658, Garnick J, 160, 174 Gimberardino MA, 342, 355
667, 668, 670, 694, 704, 739, Garrington C, 198, 201 Gimlin DR, 852, 859
741, 742, 757, 758, 761, 763, Garry JF, 593, 661 Girard K, 788, 793
766, 845, 850, 851, 852, 858, Gartner AH, 231, 258, 705, 707, 742, 743 Giray CB, 709, 744
859 Gartner LP, 35, 56 Giroud JP, 176, 199
Friend LA, 589, 660 Garvey GJ, 908, 912 Girsch WJ, 360, 403
Frigoletto RT, 869, 870, 871, 890, 897 Gascon F, 852, 859 Glantz PO, 915, 947
Frisbee HE, 871, 897 Gasse O, 132, 171 Glass RL, 870, 871, 872, 897
Frisbie HE, 163, 174 Gassner R, 801, 841 Glatt L, 511, 565
Frohlich E, 46, 58 Gatchel RJ, 5, 22 Glauser RO, 893, 902
Fromm GH, 329, 330, 331, 353, 354 Gatot A, 78, 91, 633, 665, 788, 789, 793 Glenner RA, 357, 403
Frost FA, 345, 356 Gatti J, 903, 912 Glick DH, 108, 168, 232, 235, 252, 258,
Frostell G, 78, 91 Gaudet EL, 236, 258 268, 279, 280, 281, 286, 669,
Frykholm A, 811, 819, 842 Gazelius B, 50, 51, 60, 216, 257 673, 675, 739, 756, 759, 766,
Fuchs M, 518, 567 Gedalia I, 856, 859 779, 781, 792
Fujihashi K, 178, 199 Gee JY, 655, 668 Glick M, 63, 88, 143, 172
Fuks AB, 829, 842, 869, 871, 872, 878, Geene JN, 318, 352 Glick PL, 35, 56
886, 892, 897, 898, 900, 901, Gegauff AG, 147, 173 Glickman GN, 488, 522, 561, 567
902 Gehring PE, 48, 59 Glomb TA, 868, 881, 897
Fukushima H, 68, 69, 75, 89, 91, 762, 768 Geigle H, 522, 523, 567 Glosson CR, 540, 548, 549, 569
Fulkerson MS, 517, 566 Geist JR, 238, 258 Gluskin AH, 522, 523, 567, 926, 949
Full CA, 895, 902 Gelb DA, 735, 736, 745 Goadsby PJ, 324, 352
Fulling HJ, 212, 214, 256, 257 Gelfand M, 223, 257 Goaz P, 194, 201
Fulton JF, 283, 284, 286, 316, 351 Genc A, 846, 858 Gobel H, 325, 353
Funakoshi M, 261, 285 Genco RJ, 74, 75, 91 Gobetti JP, 329, 353
Furer C, 929, 931, 949, 950 Genet J, 15, 22 Goerig AC, 224, 225, 258, 362, 403, 497,
Furseth R, 138, 155, 172, 174 Genet JM, 274, 286, 576, 657 516, 518, 563, 565, 567, 891,
Fusayama T, 48, 59, 133, 148, 171, 173, George JW, 512, 565, 640, 666 902
865, 896 Georgopoulou M, 78, 92 Goharkhay K, 551, 570, 694, 741
Fuss Z, 212, 213, 214, 257, 524, 568, 573, Gerald WG, 319, 352 Going RE, 129, 170
612, 627, 656, 663, 778, 792 Gerbe RW, 310, 351 Gold SI, 232, 258, 533, 568
Gerhardt T, 519, 567 Goldberg F, 504, 564, 577, 586, 591, 597,
G Gerosa R, 519, 521, 567, 587, 659 657, 659, 660, 662, 882, 900
Gabel WP, 541, 569 Gerstein H, 115, 168, 225, 258, 479, 486, Goldberg MH, 69, 90, 184, 200
Gaelius B, 50, 60 517, 560, 561, 566, 690, 695, Goldblatt LI, 197, 201
Gaengler P, 757, 766 698, 701, 722, 740, 741, 742, Goldman A, 850, 856, 858
Gage TW, 678, 740 744, 809, 842, 925, 949 Goldman H, 196, 201
Gagliani M, 697, 741 Gervirtz RN, 339, 340, 355 Goldman LB, 49, 50, 59, 505, 564, 597,
Galberry JH, 15, 22 Gery I, 178, 199 662
Galen EN, 4, 21 Gerzina TM, 137, 172 Goldman M, 49, 50, 59, 223, 257, 358,
Galer BS, 335, 354, 355 Gettleman BH, 597, 598, 647, 662, 667, 403, 497, 505, 563, 564, 572,
Galich JW, 517, 566 783, 793 573, 597, 615, 651, 656, 662,
Gall R, 553, 570 Gezelius B, 592, 661 664, 668
Galloway SE, 49, 59 Gharbia SE, 68, 78, 89 Goldrich N, 922, 948
Gambarini G, 655, 668 Ghebrehiwet B, 176, 199 Goldstein N, 251, 258
Gambill JM, 491, 561 Gher ME, 69, 90 Golub LM, 707, 743
Gangerosa LP, 138, 172, 265, 286, 313, Gher MJ, 68, 69, 89 Gomes B, 67, 68, 69, 89
314, 351 Giacovazzo M, 325, 353 Goncalves R, 78, 92
Garant PR, 35, 51, 56, 61 Giansanti J, 189, 201 Good DL, 884, 888, 900, 901
Goodacre C, 117, 169 Grigsby WR, 69, 90 Haddad G, 516, 520, 566
Goodell GG, 655, 668 Grimaldi J, 915, 947 Hadding U, 554, 570
Goodis HE, 552, 554, 570 Grimberg F, 524, 568 Haddix JE, 926, 949
Goodman A, 494, 562, 575, 576, 622, 657, Grimes EW, 15, 22 HaffnerC, 551, 570
664 Grimm S, 69, 90 Haga CS, 530, 568
Goodman CH, 264, 265, 266, 285 Grippo JO, 115, 168 Hagglund B, 670, 739
Goodrich JL, 836, 843 Grisdale J, 709, 744 Hagglund G, 179, 200
Goolkasian P, 339, 355 Gron P, 360, 403 Hahn CL, 69, 90, 267, 269, 286, 708, 743
Goon SK, 333, 354 Grondahl HG, 313, 314, 351 Haidet J, 494, 562
Goon WWY, 143, 172, 333, 354, 522, 523, Grondahl K, 374, 403 Haikel Y, 480, 481, 560
567, 727, 744, 779, 792, 852, Grosdenovic-Selecki S, 35, 56 Hakanson S, 334, 335, 354
859 Grosrey J, 554, 570 Hakansson J, 761, 767
Gorbeti JP, 85, 93 Grossman LI, 2, 11, 21, 22, 63, 67, 88, 89, Haley D, 304, 311, 351
Gordon E, 517, 566 104, 110, 124, 168, 170, 262, Hall DC, 44, 58
Gorlin R, 196, 201 266, 285, 575, 578, 579, 580, Hall G, 64, 88, 908, 912
Gorman DA, 331, 354 582, 588, 593, 595, 657, 658, Hall MC, 605, 662
Goto G, 119, 169 660, 661, 669, 675, 698, 701, Haller RH, 540, 548, 549, 569
Gotoh T, 106, 107, 168 727, 739, 742, 744, 786, 793 Hallett GE, 889, 901
Gottlieb B, 692, 741 Grove CJ, 573, 652, 656, 668 Halpern IL, 209, 210, 256
Gough RW, 573, 656 Grower MF, 505, 564 Halse A, 187, 201, 765, 768
Gouila CD, 394, 404 Grung B, 187, 201 Halter JB, 679, 740
Gould JM, 890, 902 Grushka M, 348, 356 Halterman CW, 894, 902
Goulschin J, 394, 404 Guerini V, 669, 739 Hamel H, 35, 56
Gouw-Soares SC, 554, 570 Guevara JJ, 122, 169 Hameroff SR, 345, 356
Gow-Gates GAE, 385, 404 Guglielmoth MB, 642, 666 Hamersky PA, 50, 59, 122, 169, 208, 256
Gracely RH, 290, 350 Guido G, 550, 569 Hamilton AI, 922, 948
Grady JR, 366, 403 Guiterrez G, 511, 565 Hammarstrom L, 28, 55, 56, 61, 836, 838,
Graff-Radford SB, 324, 328, 330, 331, 334, Gulbaivala K, 74, 91, 520, 567 839, 842, 843, 904, 912
341, 342, 345, 346, 352, 353, Guldener P, 512, 565 Hammer H, 727, 744
354, 355, 356 Gumaraes SAC, 587, 660 Hamp SE, 727, 744
Grajower R, 788, 793 Gunraz MN, 69, 90 Han SS, 34, 56, 878, 900
Granath LE, 883, 900 Guralnick W, 211, 256, 314, 351 Hand RE, 77, 91, 499, 563, 622, 664
Grane B, 690, 741 Gurfinkel J, 577, 586, 657, 659 Hans SS, 52, 61
Grant AA, 923, 926, 949 Gurmann JL, 597, 662 Hansen BF, 761, 767
Grant BE, 135, 171 Gurnery BF, 575, 657 Hansen HJ, 331, 332, 354
Gratt BM, 221, 223, 257, 334, 347, 354, Gutierrez JH, 479, 560, 572, 577, 656, 657 Hansen HP, 35, 56
356, 369, 403, 516, 566 Gutknecht N, 551, 553, 570, 694, 741 Hansen J, 189, 201
Gravenmade EJ, 885, 901 Gutmann JL, 31, 56, 530, 531, 568, 573, Hanson EC, 923, 926, 949
Graziussi G, 331, 354 583, 629, 632, 634, 636, 637, Hansson P, 39, 57
Greely CB, 862, 868, 869, 896 656, 658, 665, 666, 669, 675, Hansuck EE, 680, 740
Green D, 28, 30, 56, 176, 198, 224, 225, 680, 690, 693, 695, 698, 701, Haponik EF, 690, 741
258, 416, 511, 559, 565, 577, 704, 739, 740, 741, 742, 757, Happonen RP, 67, 68, 69, 78, 89, 759, 766
657, 697, 741 759, 762, 766, 767, 776, 792, Harashima T, 553, 570
Green EN, 473, 559 915, 947 Harbert H, 652, 668
Green TL, 186, 200, 756, 766 Gutnecht N, 554, 570 Harden RN, 335, 354, 355
Greenberg I, 501, 564 Guttenberg SA, 326, 353 Hardie EM, 628, 632, 665
Greenberg M, 893, 902 Guttman JL, 586, 659 Hardison JD, 83, 93
Greene CS, 314, 351 Guttuso J, 143, 144, 172, 589, 660 Hare GC, 110, 168
Greengard P, 674, 739 Guyton AC, 715, 744 Hargreaves KM, 910, 912
Greenhill JD, 51, 61, 264, 265, 285 Guzy GE, 915, 947 Hargrove B, 210, 256
Greenwood LF, 292, 350 Gwinnett J, 266, 286, 874, 899 Harman B, 17, 18, 19, 22, 23
Gregory WB, 143, 151, 172, 173 Harn WM, 719, 744
Grenoble DE, 143, 144, 172 H Harnden DG, 579, 657
Grenthe B, 735, 745 Haapasalo M, 68, 69, 78, 89, 92, 759, 766, Harper RH, 922, 948
Gretz SS, 339, 355 767 Harrington GW, 317, 352, 516, 566, 573,
Grey R, 416, 559 Haapasalo MPP, 764, 768 612, 656, 664, 852, 853, 859,
Grieve AR, 922, 948 Haas SB, 615, 664 919, 926, 948, 949
Griffee MB, 68, 69, 89 Haasch GC, 701, 742 Harris CA, 913, 914, 947
Griffin CJ, 38, 57 Haaselgren G, 18, 23 Harris GZ, 926, 949
Griffin JA, 748, 765 Habler HJ, 335, 355 Harris M, 284, 286, 346, 347, 356
Griffiths BM, 501, 516, 564, 565 Hachinski VC, 323, 352 Harris R, 38, 57
Harris WE, 251, 258, 773, 792 Hedberg M, 64, 88, 908, 912 Hicks J, 878, 900
Harris WH, 700, 742 Hedin M, 181, 200 Hicks ML, 77, 91, 396, 404, 652, 668
Harrison J, 186, 200, 669, 675, 739 Hedman WJ, 69, 90 Hicks VE, 490, 561
Harrison JW, 15, 22, 64, 76, 77, 88, 91, Hedrick RT, 516, 566 Higa RK, 706, 743
499, 501, 563, 564, 650, 667, Heeley JD, 862, 896 Higashi T, 887, 901
680, 684, 688, 693, 695, 705, Hefti A, 588, 660 Hildebrand K, 122, 123, 169
707, 709, 710, 740, 741, 743, Heggers J, 64, 76, 88 Hildelbert P, 79, 92
744 Heicht RC, 789, 794 Hill CM, 211, 256
Harrison SD, 347, 356 Heide S, 103, 168, 804, 808, 841, 870, 897 Hill LM, 319, 326, 352
Harry F, 492, 562 Heidemann D, 519, 567 Hill SD, 885, 901
Harstook JT, 868, 889, 897, 901 Heil J, 583, 658 Hill TJL, 181, 200
Hartwell G, 224, 225, 258, 417, 559 Heimdahl A, 64, 68, 69, 88, 89, 908, 912 Hiltner RS, 644, 666, 926, 949
Hartwell GR, 206, 256, 416, 559, 607, Heinze A, 325, 353 Himel VT, 474, 488, 490, 519, 525, 560,
663, 693, 702, 708, 741, 742, Heithersa GS, 141, 172, 232, 234, 235, 561, 567, 625, 632, 636, 652,
743, 773, 779, 792 236, 237, 238, 258, 852, 859 665, 666, 668, 773, 788, 792,
Hartzell T, 69, 90 Heitmann T, 929, 931, 949, 950 793
Harvey TF, 609, 663 Held S, 376, 404 Hine M, 188, 201
Harvey WL, 187, 200 Held-Wydler E, 867, 897 Hine MK, 163, 174, 181, 183, 200
Hasegawa K, 518, 566 Helfer AR, 788, 793, 915, 947 Hirohata K, 762, 768
Hasegawa M, 640, 666 Helig J, 887, 901 Hirsch RS, 66, 88
Hashem AF, 916, 947 Heling B, 581, 658, 785, 793 Hirschfeld Z, 856, 859, 922, 948
Hashiguchi I, 706, 743 Heling I, 78, 92, 251, 258, 580, 581, 658, Hirschmann PN, 790, 794
Hashimoto M, 889, 901 764, 768, 853, 859 Hirvonen TJ, 41, 58
Hashimoto S, 50, 60 Hellden L, 670, 739, 761, 767 Hjorting-Hansen E, 151, 173, 188, 189,
Hashioka K, 68, 69, 89 Heller D, 852, 859 201, 818, 838, 839, 842, 843
Haskell EW, 873, 898 Hellwig E, 861, 896 Hoag EP, 926, 949
Hassan A, 553, 570 Hemborough JH, 518, 567 Hobson P, 890, 902
Hasselgren G, 74, 79, 90, 92, 178, 199, Hembree J, 586, 659 Hodosh M, 266, 268, 286
232, 258, 499, 512, 557, 563, Hembree JH, 872, 898 Hoen MM, 541, 569, 605, 662
565, 570 Hemmings KW, 926, 949 Hoheisel U, 292, 350
Hassell KJ, 923, 926, 949 Hendricks-Klyvert M, 43, 58 Hokama SN, 920, 948
Hassellgren G, 877, 899 Hendry JA, 652, 653, 668, 892, 902 Holan G, 887, 892, 901, 902
Hassenbusch S, 335, 354 Hennig T, 554, 570 Holcomb J, 151, 173, 920, 948
Hastings G, 319, 326, 352 Henrici A, 69, 90 Holcomb JB, 675, 739
Hastreiter RJ, 79, 82, 92 Henry CA, 759, 766, 903, 912 Holcomb JP, 920, 948
Hata G, 612, 664 Henry EE, 117, 169 Holcomb JQ, 608, 663
Hatges NA, 198, 201 Henry PJ, 919, 920, 948 Holland GR, 35, 36, 43, 51, 56, 57, 58, 61,
Hathaway SR, 299, 350 Hepworth MJ, 670, 739 573, 641, 656, 666
Hattler AB, 122, 169 Hera SS, 690, 741 Holland R, 577, 640, 641, 652, 653, 657,
Hatton JF, 607, 663 Hering P, 551, 570 666, 668, 759, 761, 766, 767,
Hattori H, 705, 742 Herman KP, 650, 668 785, 793, 808, 841, 872, 898
Hatzikyriakos AH, 916, 917, 921, 947 Herman WW, 391, 404 Hollender L, 78, 91
Hauser MJ, 708, 743 Hernandez J, 925, 929, 949 Hollender LG, 516, 566
Hawrish CE, 522, 567 Hernandez JRP, 886, 901 Hollingshead MB, 196, 201
Hayakawa T, 873, 899 Herrmann B, 65, 88 Hollist HO, 400, 404
Hayami S, 655, 668 Herrmann JW, 789, 794 Holm SE, 67, 74, 89
Hayashi A, 66, 88 Herschowitz SB, 629, 665 Holmstrup G, 851, 859
Hayashi C, 178, 199 Hess W, 416, 559 Holroyd SV, 674, 739
Hayashi K, 705, 742 Hession RW, 746, 765 Holt SC, 65, 88
Hayden WJ, 914, 947 Heuer GA, 265, 286 Holtzman D, 359, 403
Haydenblit R, 26, 55 Heuer MA, 478, 480, 492, 502, 560, 562, Holz J, 50, 60, 870, 897
Hayduk S, 791, 794 564, 576, 582, 657, 658 Hong CU, 706, 743, 808, 841
Hayes D, 329, 330, 353 Heyeraas KJ, 50, 51, 60 Hong CZ, 338, 339, 340, 341, 342, 355, 356
Hays GL, 501, 563 Heymann HO, 850, 857, 858, 859 Hong DH, 338, 355
Hayward JR, 9, 22 Heys DR, 873, 898 Hong YC, 589, 654, 660
Haywood VB, 850, 857, 858, 859, 860 Heys RJ, 130, 132, 170, 171 Hooley JR, 680, 740
Head H, 295, 333, 350, 354 Hiatt JL, 35, 56 Hoope W, 491, 561
Healey HJ, 225, 258, 511, 516, 565, 819, Hiatt WH, 10, 22, 217, 257 Hooper WC, 790, 794
842, 847, 858 Hibbard ED, 889, 901 Hoover J, 589, 660
Healy HG, 873, 898 Hibst R, 553, 570 Hopkins JH, 573, 612, 656, 663
Hecht A, 679, 740 Hickel R, 551, 570 Hoppe W, 474, 488, 560, 561
Jones SL, 74, 90, 291, 296, 350, 759, 766 Karlsson S, 915, 916, 917, 947 663, 665
Jontell M, 34, 56, 69, 90 Karlsson UL, 43, 58 Kesel RG, 29, 56, 652, 653, 668
Joos RW, 871, 898 Kartal N, 416, 559 Kessler JC, 922, 948
Jordan E, 27, 55 Kashitani M, 701, 742 Kessler JR, 601, 662, 779, 792
Jordan RD, 397, 404 Kashiwada T, 874, 899 Ketelaer MC, 347, 356
Jordan RE, 847, 858, 868, 897 Kasirer J, 551, 570 Kettering J, 178, 199, 554, 570, 759, 766
Jordan RL, 119, 131, 133, 160, 169, 170, Kaste LM, 795, 801, 841 Kettering JD, 74, 90, 176, 178, 179, 182,
171, 174 Kastelein P, 69, 90 198, 200, 579, 587, 657, 659,
Joseph SW, 499, 563 Katchburian E, 35, 56 706, 743
Jossell S, 891, 902 Katebzadeh N, 16, 22, 829, 842 Ketterl W, 48, 59, 639, 666
Jou UT, 521, 567 Kato J, 889, 901 Key MC, 945, 950
Jou YT, 522, 567, 705, 742 Kato K, 106, 168 Keyes G, 122, 123, 169
Joy ED, 296, 350 Katoh Y, 874, 899 Khayat A, 651, 668, 758, 766
Joyce AP, 609, 663 Katz A, 513, 518, 524, 565, 567, 568 Khayat B, 47, 59
Judd P, 890, 902 Katz JO, 238, 258 Khayat BG, 176, 198
Judd PL, 892, 902 Katz V, 64, 88 Kidd EAM, 873, 898
Juel-Jenson BE, 334, 354 Katzberg RW, 315, 351 Kidder RS, 214, 257
Junakoshi E, 711, 744 Kaufman AY, 500, 501, 503, 513, 518, Kielbassa AM, 861, 896
Jung T, 177, 199 524, 563, 564, 565, 567, 568, Kielich RB, 69, 90
Jungmann CL, 530, 568 595, 661, 790, 794 Kielt LW, 497, 563
Junn D, 808, 841 Kaufman C, 134, 171 Kier DM, 268, 286
Jurcak JJ, 622, 625, 664, 665 Kaufman IJ, 96, 167 Kiger RD, 66, 74, 88, 90, 178, 200
Jurosky KA, 684, 688, 740 Kaugars G, 195, 201 Kiimura EJN, 553, 570
Justman BC, 772, 792 Kaugars GE, 670, 739 Kilhara T, 40, 57
Kavanaugh D, 540, 548, 569 Killough SA, 916, 918, 947
K Kawahara H, 132, 171 Kim B, 50, 60
Kaban LB, 211, 256 Kawakami T, 583, 589, 658, 660 Kim S, 38, 39, 40, 43, 50, 52, 57, 58, 60,
Kaffe I, 221, 223, 257, 369, 403, 511, 565 Kawamura RM, 651, 668 61, 521, 522, 567, 697, 699,
Kafrawy AH, 601, 655, 662, 668, 704, 742, Kawara M, 345, 356 719, 736, 741, 744, 745
759, 767 Kawashima N, 178, 199, 518, 566 Kimberly CL, 47, 59, 176, 198
Kahn H, 64, 88 Kayser AF, 916, 917, 947 Kimbrought WF, 636, 666
Kahnberg K, 759, 766 Kazemi RB, 478, 488, 560, 561, 580, 658 Kimura T, 874, 899
Kahnberg KE, 811, 839, 840, 842, 843 Keane KM, 573, 612, 615, 656, 664 Kimura Y, 552, 553, 570
Kai TH, 791, 794 Keate KC, 474, 560 Kinder SA, 65, 88
Kaiser F, 553, 570 Keeser W, 346, 356 Kindlova M, 41, 50, 58, 60
Kajfman AY, 502, 564 Kehl T, 47, 49, 59 King J, 868, 897
Kakehashi G, 903, 912 Kehoe JC, 577, 657 King PA, 915, 920, 926, 929, 947, 949
Kakehashi S, 65, 77, 88, 175, 198, 757, Keila S, 524, 568, 790, 794 Kingsbur B, 729, 744
766, 870, 897 Keith DA, 37, 57 Kirchoff DA, 722, 744
Kakehashi Y, 929, 931, 949, 950 Keller U, 553, 570 Kirk EEJ, 586, 659, 870, 897
Kakimoto N, 195, 201 Kellert M, 719, 744 Kischinovsky D, 785, 793
Kalins V, 871, 897 Kellgren JH, 295, 350 Kishi V, 38, 57
Kalnins V, 163, 174 Kemp WB, 143, 172 Kishi Y, 34, 56
Kalyan-Raman UP, 338, 355 Kemples D, 146, 173 Kitamura T, 214, 257
Kamath MP, 500, 563 Kennedy DB, 871, 876, 897 Klanan B, 727, 744
Kames LD, 299, 339, 350 Kennedy WA, 573, 598, 656, 662 Klayman S, 492, 561
Kaminski EJ, 582, 658 Kenney JS, 178, 199 Kleier DJ, 360, 403
Kanca J, 133, 171, 655, 668, 873, 874, 899 Kenny DJ, 833, 836, 842, 890, 892, 902 Klein H, 871, 886, 897, 901
Kanjihan R, 291, 296, 350 Kent BE, 131, 171 Kleinberg I, 262, 285
Kantz WE, 903, 912 Kepler EE, 49, 50, 59, 60 Kleinberg K, 264, 265, 285
Kao Y, 376, 404 Kerebel B, 35, 38, 56 Kleinegger CL, 338, 355
Kapa S, 374, 403 Kerebel LM, 35, 38, 56 Klevant FJH, 748, 751, 766
Kapala JT, 871, 876, 897 Kerekes K, 151, 173, 474, 560, 612, 663, Klieman DJ, 329, 353
Kaplan AP, 176, 199 746, 759, 765, 766, 808, 841, Klier DJ, 595, 661
Kaplowitz GJ, 612, 646, 664, 667 870, 897 Kline RW, 331, 354
Kapsimalis P, 392, 404, 572, 586, 589, Kerezoudis N, 189, 201 Kling M, 836, 843
656, 659, 660 Kerhove BC, 868, 897 Klotzer WT, 131, 171
Karapanou V, 926, 949 Kern M, 929, 949, 950 Kniaz A, 518, 567
Kariyawasam SP, 706, 743 Kerr DA, 9, 22 Knibbs PJ, 524, 568
Karjalainen S, 50, 60 Kerr FWL, 292, 296, 350 Knowles KI, 548, 549, 569
Karlsen K, 149, 173 Kersten HW, 573, 626, 627, 629, 633, 656, Ko CC, 916, 947
Koba K, 552, 570 629, 646, 647, 654, 665, 667, Langeland K, 37, 40, 41, 44, 45, 53, 54,
Kobayashi C, 405, 517, 518, 520, 521, 668, 764, 768 57, 58, 66, 69, 78, 88, 90, 92,
522, 523, 524, 558, 566, 567, Kreutziger KL, 314, 351 96, 97, 101, 103, 104, 107,
568 Krey G, 59, 63, 73, 88, 757, 766 110, 117, 118, 123, 124, 129,
Kobayashi T, 66, 88 Krmec D, 853, 859 133, 134, 143, 144, 145, 148,
Koch G, 878, 900 Kroeger DC, 50, 60 150, 153, 157, 163, 167, 168,
Koch KA, 632, 665 Kroening R, 304, 311, 335, 351, 355 169, 170, 171, 172, 173, 174,
Koenig K, 729, 745 Krol AJ, 329, 353 329, 353, 499, 511, 512, 517,
Koerber A, 359, 403 Kronfeld R, 69, 90, 189, 201 563, 565, 566, 586, 587, 588,
Kogushi M, 34, 56 Kronman JH, 49, 50, 59, 505, 564 593, 646, 659, 660, 661, 667,
Koh ET, 706, 743, 773, 779, 792 Kuan TS, 339, 355 670, 739, 764, 768, 869, 870,
Kohler CA, 684, 740 Kuhn A, 850, 858 897
Kojima Y, 292, 296, 350 Kuhre AN, 601, 662 Langeland L, 117, 134, 169, 171, 761, 767
Koka S, 705, 742 Kulid JC, 78, 92, 416, 559, 689, 740, 926, Langeland LK, 103, 129, 143, 144, 148,
Kolinick J, 519, 567 949 168, 170, 172, 173
Kollman W, 270, 286 Kullendorf B, 374, 403 Langer B, 727, 744
Kolokuris I, 575, 584, 588, 597, 657, 658, Kumada H, 707, 743 Langloss J, 376, 404
660, 662 Kumar V, 165, 174 Lantz B, 773, 792
Koltzenburg M, 335, 355 Kunc Z, 292, 350 Larach-Robinson D, 259, 285, 312, 314,
Komiyama O, 345, 356 Kunkel RS, 326, 353 347, 348, 351
Komori S, 520, 521, 567 Kuo ML, 74, 90, 178, 199 Larato DC, 922, 948
Komori T, 694, 741 Kurer HG, 923, 926, 949 Larder TC, 612, 663
Komorowski R, 704, 742 Kuruvilla JR, 500, 563 Lares C, 612, 663
Konaga E, 701, 742 Kuttler Y, 30, 56, 224, 225, 258, 416, 417, Lares-Ortiz C, 633, 663
Kondell PA, 701, 742 472, 511, 516, 559, 565, 573, Largent MD, 889, 902
Kondo A, 331, 354 656, 697, 741 Larsen A, 178, 199
Kondo S, 157, 159, 174 Kuwabara RK, 866, 896 Larsen TD, 651, 668
Kono Y, 178, 199 Kvinnsland I, 47, 50, 51, 59, 774, 792 Larson W, 186, 200
Kontakiotis E, 78, 79, 92 Kvist T, 68, 78, 89, 645, 667, 764, 768, Larsson AP, 69, 90
Kontiainen S, 68, 78, 89 923, 926, 949 Larz SW, 478, 560
Kopel HM, 143, 144, 172, 874, 878, 886, Kvittem B, 795, 841 Laskin DM, 314, 351
891, 899, 901, 902 Kwan EH, 926, 949 Latcham NL, 852, 853, 859
Kopp S, 313, 314, 351 Kytridou V, 636, 666 Lau TC, 106, 168
Kopp WM, 503, 564 Lauer HC, 117, 169
Koppang G, 759, 767 L Lauper R, 517, 566
Koppang H, 759, 767 LaBanc JP, 595, 661 Laurberg S, 316, 351
Kortsaris AH, 584, 658 LacCombe JS, 612, 663 Lauritzen M, 323, 352
Korzen GH, 176, 198 Lacy AM, 130, 131, 170 Lavin MT, 705, 742
Koss S, 925, 929, 949 Ladd RL, 52, 61 Law DB, 877, 883, 899, 900
Kota K, 78, 91 Ladley RW, 646, 667 Law DC, 861, 876, 890, 896
Kotilainen R, 670, 739 Lado EA, 852, 853, 859, 868, 872, 897, Laws AL, 532, 568, 652, 653, 668
Kotowicz WE, 926, 949 898 Laxansky JP, 179, 200
Koulaouzidou E, 584, 658, 852, 859 LaFleche RG, 36, 51, 57 Layton CA, 704, 742
Kouri EM, 887, 901 Laha JM, 331, 354 Layzer RB, 337, 355
Koutayas SO, 929, 949, 950 Laha RK, 330, 353 Lazansky JP, 11, 22, 358, 403
Kovacevic M, 517, 566 Laird JM, 290, 350 Lazorthes Y, 331, 354
Kraintz L, 41, 50, 53, 58, 60 Lake FT, 52, 53, 61, 847, 852, 858 Lazzari EP, 499, 563
Krakow AA, 176, 198, 650, 667, 884, 894, Laliga RM, 516, 566 Lazzaro M, 178, 199
900, 902 LaLonde ER, 358, 403 Leary JM, 915, 922, 947, 948
Kramer GM, 107, 168, 701, 742 Lambjerg-Hansen H, 593, 661, 851, 859, Leblond CP, 34, 35, 56
Kramer IRH, 30, 40, 56, 115, 168 877, 899 LeClaire AJ, 5, 22
Krant KS, 317, 352 Lambrianidis T, 223, 257, 394, 404, 631, Leddy BJ, 516, 566
Krasner P, 275, 286, 833, 842 665 Ledesma-Montes C, 584, 658
Krasny RM, 203, 256 Lamers AC, 650, 667 Lee FS, 622, 664
Kratchman S, 729, 745 Lampert F, 553, 554, 570 Lee H, 133, 171
Krause DC, 696, 741 Lamster IB, 74, 90, 178, 199 Lee HY, 791, 794
Krauser JT, 264, 285 Lan WH, 500, 552, 563, 570 Lee KH, 331, 354
Krejci RF, 122, 169, 920, 922, 923, 948 Lance JW, 304, 323, 350, 352 Lee LW, 500, 563
Krell KV, 212, 213, 257, 397, 404, 416, Landau M, 887, 901 Lee MC, 916, 947
494, 495, 501, 517, 518, 520, Landay MA, 114, 168 Lee SJ, 651, 668, 758, 766, 773, 792
529, 559, 562, 564, 566, 567, Landers RR, 15, 16, 22 Lee YC, 650, 667
Leeb JI, 533, 569 Lieseinger AW, 275, 286 Lopes MA, 143, 172
Lefkowitz W, 117, 138, 169, 172 Liesinger LW, 275, 286 Lord JL, 6, 22, 939, 944, 950
Legan HL, 123, 163, 169, 174 Liewehr FR, 625, 626, 665 Lorton L, 580, 615, 658, 664, 854, 859,
Legan JJ, 655, 668, 704, 742 Lifshitz J, 619, 664 923, 926, 949
Legrand Y, 701, 742 Lilja J, 43, 58 Lost C, 522, 523, 567, 759, 762, 766, 768,
Lehr T, 856, 859 Liljenberg B, 74, 90 850, 858
Leiberman A, 78, 91 Lilley JD, 67, 68, 69, 89, 576, 657 Lous I, 323, 346, 352
Leidal TI, 133, 171 Lilly GE, 338, 355, 589, 660, 710, 744 Loushine R, 359, 403, 675, 736, 739, 745
Leinfelder KF, 138, 147, 172, 173, 584, Lim GC, 178, 199 Loushine RJ, 606, 609, 662, 663
587, 659 Lim KC, 530, 568, 586, 650, 659, 667, Lovdahl PE, 675, 740, 915, 947
Lekholm U, 74, 90, 670, 739, 761, 767 870, 897 Lovely TJ, 331, 354
Lekka M, 886, 901 Lim SS, 779, 792 Lovshin LL, 319, 326, 352
Lemon R, 854, 859 Limkangwalmongkol S, 583, 658 Lowman JV, 30, 56
Lemon RR, 644, 666, 699, 742, 925, 926, Lin CP, 552, 570 Lownie JR, 700, 742
949 Lin L, 329, 353, 517, 566 Lu YC, 915, 920, 947
Lengheden A, 836, 843 Lin LC, 852, 859 Luccy CT, 612, 663
Lentine FN, 480, 560 Lin LM, 107, 157, 168, 174, 471, 559, 757, Luciano J, 518, 567
Lento CA, 396, 404 759, 766, 767, 852, 859 Ludington JR, 214, 257, 926, 949
Leonard LA, 138, 172 Lin PC, 573, 656 Ludlow MO, 650, 668
Leonard M, 389, 404 Lin PS, 49, 50, 59 Luebke G, 673, 739
Leonard RH, 858, 860 Lind PO, 96, 167 Luebke NH, 492, 562
Leonardo MR, 588, 591, 641, 660, 666 Linde LA, 918, 919, 921, 948 Luebke NJ, 493, 562
Leonardo RD, 478, 560 Lindhe J, 66, 74, 88, 90, 97, 167, 727, 744 Luebke RG, 683, 740
Lertchirakarn V, 608, 663 Lindner V, 325, 353 Lugassy AA, 573, 620, 656, 664
Lervik T, 103, 168 Lindorf HH, 680, 690, 740 Luiten D, 77, 91, 540, 548, 549, 569
Leseberg DA, 485, 561 Lindskog S, 55, 61, 231, 234, 258, 388, Lukic A, 74, 90
Lester KS, 597, 662 404, 837, 843, 905, 912 Luks S, 479, 560
Leubke RG, 926, 949 Lindvall AM, 852, 853, 859 Lumley PJ, 495, 497, 540, 548, 562, 563,
Leuck M, 416, 559 Linenberg WB, 181, 200, 358, 403 569, 704, 742
Leung B, 376, 378, 404 Linke HAB, 601, 662 Lumsden AGS, 26, 27, 55
Leung RL, 867, 897 Linney AD, 516, 565 Lund MR, 922, 948
Lev R, 494, 497, 562, 563 Linoff K, 21, 23 Lundberg M, 151, 165, 173, 174, 785,
Levine JD, 335, 355 Liolios E, 597, 662 793, 804, 808, 841
Levine LH, 688, 740 Lipman AG, 336, 355 Lundergan WP, 779, 792
Levine M, 2, 21, 473, 559 Lipp M, 679, 740 Lundgren JP, 911, 912
Levy AB, 188, 201, 511, 565 Lipton JA, 259, 285 Lundquist P, 916, 917, 947
Levy BAA, 759, 766 Lipton JH, 312, 351 Lundy T, 131, 171, 870, 897
Levy BM, 40, 53, 58, 122, 169, 181, 183, Listgarten MA, 122, 169 Lunsford LD, 331, 354
200 Liu HC, 552, 570 Lupe-Zuniga JL, 178, 199
Levy G, 551, 570 Liu MT, 39, 57 Luscher B, 122, 169
Levy JA, 143, 172 Livingston HM, 847, 858 Lussi A, 554, 570
Lewin B, 761, 767 Livingston MJ, 48, 49, 50, 59 Lussier A, 176, 199
Lewinstein I, 788, 793, 852, 854, 856, 859 Lloyd JM, 886, 901 Lustman J, 829, 842
Lewis BB, 579, 657 Lloyd PM, 924, 949 Luthy H, 929, 949, 950
Lewis JM, 514, 565 Lloyd RE, 791, 794 Lutz F, 517, 566
Lewis MAO, 69, 90 Loadholt C, 474, 560 Lynch EJ, 232, 258
Lewis RD, 579, 657, 917, 919, 947 Lochary MW, 847, 858
Lewis TM, 861, 867, 876, 877, 890, 896, Lockett BC, 892, 902 M
897, 899 Lockhard PB, 822, 842 Maas R, 26, 27, 55
Lewit K, 338, 341, 345, 355, 356 Lockhart PB, 123, 169, 847, 858 MacDonald JB, 110, 168
Leyhausen G, 583, 658 Loe H, 678, 740 Macfarlane JD, 143, 172
Lhermitte J, 333, 354 Loel DA, 597, 662 Macfarlane TW, 69, 74, 90, 759, 762, 766,
Li T, 652, 668 Loeser JD, 330, 353 768
Li Y, 856, 857, 859 Loest C, 584, 658 MacGregor AB, 40, 57, 101, 167, 865, 896
Lian JB, 37, 57 Loetscher CA, 388, 404 Machian GR, 483, 560
Liaw LHL, 554, 570 Logue B, 510, 564 Machtou P, 542, 569, 581, 608, 617, 658,
Liaw LI, 551, 569 Loh HS, 516, 565 663, 664, 670, 739
Liberman RP, 306, 351 Lomcali G, 759, 766 Mack RB, 888, 894, 901, 902
Libfeld H, 416, 559 Lommel TJ, 809, 842, 925, 949 Mackenzie D, 74, 90, 759, 762, 766, 768
Libman WJ, 926, 927, 949 Loney RW, 926, 949 Mackie IC, 524, 568, 799, 841
Liem RSB, 315, 351 Loos PJ, 878, 900 Mackler BF, 74, 90
Macko D, 133, 171 Marsh SJ, 889, 902 Maul GG, 40, 58
MacNeil RL, 26, 27, 28, 55 Marshak BL, 920, 948 Maurice CG, 138, 172
Macphee R, 684, 740 Marshall FJ, 49, 59, 77, 91, 275, 286, 502, May A, 324, 352
Maddalozzo D, 370, 403 533, 564, 569, 573, 656, 697, Mayeda DL, 520, 567
Madden PW, 791, 794 741, 785, 793 Mayer A, 639, 666
Madden RM, 499, 563 Marshall GW, 480, 552, 560, 570, 707, Mayfield SH, 331, 354
Maddox L, 575, 657 743 Mayne JR, 577, 657
Madeina MC, 417, 559 Marshall JA, 77, 91 Mazur B, 66, 88, 110, 168
Mader CL, 77, 78, 91, 505, 564 Marshall JG, 275, 286, 540, 548, 549, 569, McAndrew R, 922, 948
Madison S, 397, 404, 651, 668, 764, 768, 694, 704, 741, 742 McCallum RE, 69, 90
852, 859, 923, 925, 949 Marshall SJ, 552, 570 McClanahan SB, 652, 668
Maeda H, 706, 743 Martelletti P, 325, 353 McClendon JL, 790, 794
Maeda K, 178, 199, 875, 899 Martin GR, 26, 55 McClugage SG, 122, 169
Maekawa Y, 65, 78, 88 Martin H, 78, 91, 494, 525, 562, 568, 576, McComb D, 131, 171, 505, 564, 580, 597,
Maerki HS, 650, 667 625, 633, 657, 663, 665 658, 662
Maggio J, 573, 586, 656, 659 Martin N, 922, 948 McConnell G, 181, 200
Magnusson BO, 877, 878, 899 Martin TR, 576, 657 McDavid WD, 516, 566
Magnusson T, 314, 351, 516, 565, 761, Martinelli C, 181, 200 McDonald AV, 915, 920, 947
767, 916, 921, 947 Martinez-Insua L, 929, 949, 950 McDonald F, 706, 743
Magura ME, 651, 668 Martinoff JT, 914, 916, 917, 921, 947 McDonald MN, 612, 664
Mahan PE, 313, 314, 351 Martinsson T, 916, 921, 947 McDonald NJ, 518, 519, 520, 522, 567,
Maillet WA, 694, 741 Marxe RE, 254, 258 650, 667, 675, 692, 739, 741
Maina G, 348, 356 Masada MP, 178, 199 McDonald RE, 706, 743, 861, 862, 863,
Makkawy HM, 705, 742 Maseki T, 587, 660 864, 869, 873, 876, 877, 896,
Makkes PC, 232, 258 Mason RG, 701, 742 898, 899
Malamed SF, 384, 385, 388, 391, 404, 678, Mass E, 524, 568, 892, 902 McDonald RF, 877, 899
740 Masserann J, 647, 667 McDougall IG, 652, 668
Maler Y, 261, 285 Massey EW, 329, 353 McDowell GC, 926, 949
Malmcrona E, 761, 767 Massey J, 329, 353 McGinn JH, 511, 565
Malmgren B, 811, 819, 837, 842, 843 Massilamoni CRM, 176, 198 McGowan DA, 69, 90
Malmgren O, 811, 819, 842 Massler M, 66, 88, 101, 108, 110, 151, McGrannahan WW, 790, 794
Malooley J, 612, 663, 759, 767 163, 167, 168, 173, 174, 573, McGuire S, 889, 901
Maltz DO, 915, 947 656, 862, 863, 865, 866, 868, McHugh JW, 143, 144, 172
Mandel E, 471, 516, 559, 565 876, 896, 897, 899 McInerney ST, 650, 667
Manhart JJ, 641, 666 Massone EJ, 505, 564 McKay RJ, 797, 841
Manhoff DT, 198, 201 Mathewson RJ, 871, 884, 891, 897 McKee MN, 360, 403
Maniatopoulos C, 36, 57 Mathias RG, 81, 92 McKendry DJ, 482, 501, 517, 529, 539,
Mann SR, 633, 663 Mathiesen A, 178, 199 560, 564, 566, 569, 706, 743
Manncke B, 759, 762, 766, 768 Mathis BJ, 329, 353 Mckenna R, 727, 744
Mannocci F, 584, 587, 659 Matiz RAR, 759, 767 McKinley B, 616, 664
Manson-Hing LR, 516, 565 Matoba K, 520, 522, 567 McKinley JC, 299, 350
Mansukhani H, 876, 899 Matre R, 74, 90 McKinney R, 179, 200
Mantilla EG, 759, 767 Matsen FA, 47, 59 McLachaln EM, 335, 355
Marbach JJ, 346, 347, 356 Matson MS, 317, 352 McLario KJ, 709, 743
Marceau F, 176, 199 Matsumiya S, 157, 174, 889, 902 McLean JW, 132, 171
March CJ, 178, 199 Matsumoto A, 178, 199 McLundie AC, 789, 794
Marciano J, 576, 657 Matsumoto K, 375, 404, 552, 553, 570, McMahon RE, 904, 912
Margarone JE, 700, 742 584, 587, 588, 659, 660, 694, McMillan PJ, 179, 200
Margelos J, 597, 662 741 McMinn RG, 43, 58
Marin PD, 852, 859 Matsumoto T, 748, 765 McMurtey LG, 633, 663
Marion D, 35, 56 Matsumoto Y, 694, 741 McNicholas S, 177, 199
Marker VA, 709, 710, 744 Matsumura S, 195, 201 McNulty WH, 339, 340, 355
Markowitz NR, 839, 840, 843 Matsura T, 136, 172 McQuay HJ, 347, 356
Marks JM, 244, 258 Matteson SR, 360, 403 McQueen D, 690, 741
Markula-Liegau A, 522, 567 Matthews B, 214, 257 McQuillen JH, 555, 556, 570
Marlin J, 576, 629, 632, 657, 665 Matthews JL, 887, 901 McSpadden J, 532, 568, 626, 665
Maroon JC, 329, 353 Matthews KL, 26, 55 McSpadden JT, 546, 569
Marosky JE, 650, 667 Mattison GC, 586, 645, 659, 667 McWalter GM, 633, 663, 873, 898
Marques MD, 761, 762, 767 Mattison GD, 923, 926, 949 Meadows D, 704, 742
Marraro RV, 86, 93 Matton G, 709, 743 Mechanowicz AE, 674, 739
Marsh RA, 516, 565 Mattsson T, 701, 742 Mecifi KB, 41, 43, 58
Medawar PB, 259, 285 Miles DA, 516, 566 Monson DL, 138, 172
Medawar PD, 204, 256 Milgrom P, 5, 17, 22 Montgomery S, 78, 86, 91, 93, 480, 485,
Meedhan JG, 716, 744 Milledge T, 804, 841 497, 516, 560, 561, 563, 566,
Meeuwissen R, 746, 765, 916, 947 Miller CH, 68, 69, 78, 83, 85, 89, 91, 93, 595, 612, 650, 661, 663, 668,
Meglio M, 331, 354 706, 743 852, 853, 859
Mehl A, 551, 570 Miller GD, 147, 173 Monzi C, 141, 172
Meimans IT, 650, 667 Miller GS, 35, 56, 155, 174 Moodnik R, 499, 563
Meinig G, 64, 88 Miller WA, 151, 173 Moodnik RM, 597, 662, 702, 742
Meister F, 115, 168, 809, 842 Miller WD, 65, 88, 865, 896 Moore P, 716, 744
Mejare I, 836, 843, 871, 875, 879, 897, Milne RJ, 292, 350 Moore RE, 490, 561
899, 900 Milot P, 926, 949 Moorer WR, 576, 657
Mejia JL, 400, 404, 791, 794 Milthon R, 670, 739, 761, 767 Moos KF, 840, 843
Melcer J, 122, 169 Min MM, 704, 742 Mor C, 845, 851, 857, 858, 859
Melfi RC, 855, 859 Minabe M, 707, 743 Moragan L, 540, 548, 549, 569
Melnick S, 788, 793 Minani C, 134, 171 Morand M, 160, 174
Melrose RJ, 143, 144, 172 Minton G, 791, 794 Morand MA, 762, 768
Melton DC, 388, 404, 650, 667 Mintz G, 759, 767 Morawa AP, 878, 900
Melzack R, 297, 298, 350 Miserendino LJ, 122, 169, 482, 560 Moreira B, 761, 762, 767
Mendel RW, 586, 659 Misgav R, 852, 859 Moreno A, 628, 665
Mendell LM, 290, 349 Misotten A, 709, 743 Morfis A, 511, 565
Mendenhall R, 104, 120, 168 Misrendino LJ, 484, 497, 552, 561, 563, Morfis AS, 608, 663, 916, 918, 947
Mendis BRRM, 37, 57 570, 694, 741 Morgan GA, 106, 168
Menegazzi G, 519, 521, 567 Mitchell DF, 67, 88, 124, 129, 170, 358, Morgan LA, 77, 91, 694, 704, 741, 742
Menke RA, 518, 567 403, 474, 560, 873, 876, 877, Morgan LF, 535, 569
Mense S, 292, 293, 342, 350 898, 899 Morgano SM, 916, 918, 929, 947, 950
Mentink AGB, 916, 917, 947 Mitchell E, 83, 93 Morgulis JR, 217, 257
Merrill RB, 106, 168, 211, 256 Mitchell R, 83, 93 Mork T, 359, 403
Merrill RG, 314, 351 Mitchell RG, 328, 353 Mork TO, 655, 668
Merrill RL, 328, 353 Mitchell SW, 335, 354 Morrison SW, 474, 560, 601, 662
Merson SA, 146, 173 Mittal M, 588, 660, 773, 792 Morrow RM, 945, 950
Meryon SD, 132, 171, 587, 659, 660 Miyakoshi S, 136, 172, 873, 899 Morse DR, 154, 174, 179, 189, 200, 201,
Messer HH, 18, 23, 52, 61, 78, 91, 573, Miyamoto O, 876, 880, 899, 900 275, 286, 588, 592, 615, 660,
608, 636, 656, 663, 665, 759, Miyasaki C, 86, 93 661, 664, 675, 740, 746, 765
767, 789, 794, 915, 947 Miyauchi M, 177, 199 Morshead C, 333, 354
Messer LB, 885, 900 Mize SB, 474, 480, 560 Mortiz A, 551, 570, 694, 741
Messing JJ, 578, 579, 657 Mizel SB, 178, 199 Morton TH, 888, 901
Meteora M, 149, 173 Mizrahi SJ, 483, 560 Moser JB, 478, 492, 502, 560, 562, 564,
Metzger Z, 612, 615, 664 Mizutani T, 472, 559 582, 658
Metzler RS, 78, 91 Mjor IA, 36, 38, 40, 41, 43, 50, 57, 58, 60, Moshonov J, 551, 570, 836, 843
Meyer FW, 895, 902 97, 101, 103, 124, 134, 138, Moskow A, 275, 286
Meyer MW, 40, 50, 52, 58, 60 149, 155, 167, 168, 170, 171, Moskowitz MA, 323, 352
Meyer W, 29, 56 172, 173, 174, 572, 573, 580, Mosley B, 178, 199
Meyerson BA, 334, 335, 354 588, 656, 657, 660, 868, 870, Moss R, 690, 741
Meyron SD, 102, 167 873, 897 Moss-Salentijn L, 43, 58
Mezawa S, 520, 521, 567 Moccaia FF, 733, 745 Moss SJ, 861, 896
Micallef J, 608, 663 Mock D, 346, 356 Mott AE, 348, 356
Micallef JP, 542, 569 Mogens JL, 130, 170 Mouyen F, 371, 403
Michaelis M, 335, 355 Mohammad AR, 587, 659 Mudder GR, 885, 901
Michailesco PM, 576, 657 MohdSulong MZA, 501, 564 Mujica F, 577, 657
Michanowicz AE, 512, 565, 573, 612, 633, Moiseiwitsch JR, 675, 740 Mulder J, 916, 947
656, 663, 664 Molander A, 68, 78, 89, 764, 768 Mulhern JM, 15, 22
Michanowicz JR, 512, 565 Molinari R, 697, 741 Mullaney TP, 216, 257, 472, 512, 525,
Michel RC, 198, 201 Moller AJR, 67, 74, 89, 175, 198, 757, 766 559, 565, 568
Michelich RJ, 214, 257 Molller E, 178, 199 Mumford JM, 149, 173
Michelich VJ, 49, 59, 102, 167, 707, 743 Molloy D, 584, 655, 658 Munaco FS, 587, 659
Mickel AK, 78, 92, 580, 658 Molven O, 3, 21, 187, 201, 492, 561, 759, Mundell RD, 674, 739
Midrou T, 176, 199 765, 766, 768 Mundy GR, 178, 199
Miehlke K, 338, 355 Molyvdas I, 631, 665 Munford P, 306, 351
Miki Y, 177, 199 Mombelli A, 733, 745 Mungel C, 540, 569
Mikkonen M, 746, 751, 765 Mondelli J, 651, 668, 922, 948 Muniz MA, 882, 900
Milam SB, 674, 739 Monsef M, 773, 792 Munksgaard EC, 707, 743
Munsell WP, 791, 794 416, 559, 595, 661 Norman JE, 317, 352
Muntz JA, 102, 138, 167, 172, 865, 896 Nedderman TA, 693, 702, 741, 742 Norris JP, 78, 91, 494, 562
Munzenmayer C, 385, 404 Nedwin GE, 178, 199 Nosonowitz D, 729, 745
Murakami S, 195, 201 Neev J, 551, 554, 569, 570 Noujaim AA, 872, 898
Murata SM, 69, 74, 90, 759, 766, 854, 859 Negm MM, 593, 661, 873, 898 Noyes FB, 40, 52, 57, 61
Murata SS, 577, 657 Neiburger EJ, 593, 661 Nuckolls GH, 27, 55
Murgel C, 417, 559 Neidle EA, 679, 740 Nuebler-Moritz M, 551, 554, 570
Muroff FI, 922, 948 Nelson EH, 711, 744 Nulson F, 335, 355
Murphy PM, 518, 522, 567 Nelson IA, 746, 751, 765 Numeroff K, 1, 21
Murphy WK, 670, 739 Nelson R, 50, 60 Nunn MH, 636, 666
Murrey A, 872, 898 Nelson SD, 910, 912 Nurmikko TJ, 321, 333, 352, 354
Murthy KS, 264, 285 Nelson WE, 797, 841 Nussbacher U, 554, 570
Muruzabal M, 589, 591, 660 Nelvig P, 371, 403 Nustein J, 389, 404
Musikant BL, 920, 923, 928, 948 Nemetz H, 135, 171 Nutting EB, 851, 859
Muzzin KB, 264, 285 Nenzen B, 311, 351 Nyary I, 331, 354
Myers DR, 52, 53, 61, 885, 886, 895, 900, Neo J, 494, 562, 646, 667 Nyborg H, 145, 163, 173, 174, 871, 878,
901, 902 Nery MJ, 759, 766 898, 900
Neubuser A, 26, 55 Nye BA, 347, 356
N Neut C, 79, 92, 650, 667 Nygaard Ostby B, 124, 134, 170, 171, 504,
Naaman A, 522, 523, 567 Neville B, 194, 198, 201 530, 564, 568, 572, 573, 574,
Naef R, 929, 949, 950 Nevins AJ, 74, 90, 178, 200, 652, 668, 885, 580, 656, 657, 785, 793
Naess G, 41, 50, 58, 60 901 Nyman S, 727, 744
Nagai O, 783, 793 Newman JG, 479, 560
Nagasawa H, 15, 22 Newsman MG, 110, 168 O
Nahmias Y, 517, 566 Newton CW, 15, 22, 78, 91, 500, 516, 563, Oakley J, 716, 744
Nahri M, 47, 59 566, 593, 601, 661, 662, 670, OBrien MD, 325, 353
Nahri MVO, 51, 61, 262, 285 739, 788, 793 Ochoa J, 332, 354
Naidorf IJ, 67, 89, 176, 179, 198, 908, 912 Nguyen HQ, 524, 568 OConnell DT, 492, 561
Naidorf K, 154, 174 Nguyen L, 704, 742 Odell EL, 65, 88
Nair PNR, 59, 63, 69, 70, 71, 72, 73, 88, Nguyen NT, 516, 566, 729, 745 Odell LJ, 69, 90
90, 181, 187, 200, 201, 757, Nicholas M, 333, 354 ODell N, 847, 852, 858
759, 762, 766, 767, 768, 903, Nicholaus BE, 500, 563 Odesjo B, 670, 739, 761, 767
912 Nicholls JI, 480, 540, 560, 569, 915, 919, Odman PA, 915, 916, 917, 929, 947, 949
Najjar TA, 674, 739 926, 927, 947, 948, 949 Oehlers FA, 104, 168
Nakabayashi N, 133, 135, 171 Nicholson RJ, 516, 566 Offenbacher S, 64, 88
Nakamura H, 587, 660, 872, 898 Nicoll BK, 518, 522, 567, 655, 668 Ogilvie RW, 50, 60
Nakamura M, 518, 566, 888, 901 Nielsen TH, 580, 658 OGrady JF, 78, 92
Nakamura S, 34, 56 Niemann RW, 416, 559 Oguntebi B, 69, 90, 512, 565
Nakamura Y, 518, 566 Niemczyk SP, 496, 563, 697, 741 Oguntebi BR, 275, 286
Nakamuta H, 15, 22, 706, 743 Nigam A, 709, 743 Ohashi M, 518, 566
Nakane A, 68, 69, 89 Nihei M, 518, 566 Ohman AE, 67, 89
Nakashima M, 876, 887, 899 Nii K, 521, 567 Ohzei H, 123, 169
Nakata TT, 773, 779, 792 Nilson R, 74, 90 Oikarinen K, 797, 822, 823, 839, 840,
Nakou M, 78, 92 Nilsson G, 50, 60 841, 842, 843
Nalbandian A, 36, 57 Nirschl R, 868, 897 Okabe A, 48, 59
Nand R, 123, 169 Nishino PK, 882, 900 Okada H, 177, 199
Nanda R, 163, 174 Nissan R, 78, 92, 651, 668, 836, 843 Okamoto H, 887, 901
Narhi MVO, 41, 43, 58 Nissle RR, 711, 744 Okamura K, 50, 60
Nash, 19, 23 Nist R, 389, 404, 679, 740 Okeson JP, 304, 312, 336, 337, 338, 343,
Nasstrom K, 222, 257 Nitta LK, 551, 569 347, 351, 355
Nathanson D, 855, 859 Nitzan EW, 595, 661 Okifuji A, 297, 350
Nation W, 804, 841 Niv D, 518, 567 Okiji T, 69, 90, 518, 566
Natkin E, 11, 22, 114, 168, 243, 258, 317, Nixon C, 923, 926, 949 Okuse K, 48, 59
352, 609, 663, 753, 766, 784, Noble W, 791, 794 OLeary TJ, 711, 744
793, 852, 853, 859 Nobuhara WK, 179, 200, 276, 286 Olesen J, 323, 352
Nauman P, 330, 353 Noguera AP, 650, 667 Olet S, 478, 560
Navarro LF, 516, 566 Nord CE, 67, 68, 69, 78, 89, 91 Olgart L, 50, 51, 60, 102, 167, 802, 841
Navez ML, 348, 356 Nordenram A, 701, 742 Olgart LM, 43, 49, 58, 59
Neagley RL, 923, 949 Nordenval K, 132, 171 Oliet S, 15, 16, 22, 576, 657, 669, 739,
Neal RG, 479, 560 Nordenvall KJ, 388, 404 786, 793
Neaverth EJ, 224, 225, 227, 258, 362, 403, Nordstrom DO, 868, 897 Oliver RC, 217, 257
Olmstead JS, 650, 667 Palmer ME, 107, 168 Peled M, 187, 201
Olsen I, 64, 76, 88, 759, 762, 766, 768 Palmer P, 47, 59 Pellen GB, 587, 659
Olson AK, 516, 518, 565, 567, 633, 663 Palmqvist S, 761, 767, 915, 947 Pellen GV, 30, 56
Olson C, 368, 403 Pameijer CH, 131, 132, 171, 872, 874, Pelleu GB, 920, 948
Olson RAJ, 701, 742 898, 899 Pelznes RB, 134, 171
Olsson B, 79, 92, 588, 660, 761, 767 Pamenius M, 929, 949 Penick EC, 143, 172, 179, 200
OMeara JA, 49, 59 Pankhurst CL, 141, 172, 254, 258 Peniston SG, 910, 912
Onai B, 583, 584, 658 Panopolos P, 50, 60 Penman J, 328, 353
Oner R, 589, 660 Pantera EA, 79, 92, 214, 215, 257 Penney J, 636, 666
Ong EY, 516, 566 Pantschev A, 707, 743 Pennisi E, 910, 912
Onno E, 395, 404 Pao Y, 922, 948 Pepersach WJ, 123, 169
Ono H, 889, 901 Pappin J, 533, 569 Percinoto C, 587, 660
Onofrio BM, 330, 353 Parahy E, 617, 664 Perel ML, 922, 948
Oppenheimer S, 650, 667 Parameswaran A, 548, 569 Perl ER, 335, 355
Orahood JP, 650, 667 Parente SA, 391, 404 Perlich MA, 30, 56
Orban B, 104, 119, 120, 163, 168, 169, Parham P, 48, 59 Pernow B, 289, 349
174, 573, 656 Parikh SR, 868, 897 Peron LC, 593, 661
Oren E, 920, 948 Park NH, 265, 286 Perot WJ, 576, 657
ORiordan MW, 889, 902 Park YG, 331, 354 Perrini N, 178, 199
Orlay H, 595, 661, 786, 793 Parker MW, 920, 948 Person P, 329, 353, 833, 842
Orlay JG, 732, 745 Parkins FM, 847, 855, 858, 895, 902 Persson P, 773, 792
Orlowski J, 133, 171 Parks HF, 36, 57 Persson R, 178, 199, 727, 744
Orowitz I, 791, 794 Parris L, 392, 404 Persson S, 68, 78, 89, 764, 768
rstavik D, 16, 18, 22, 23, 78, 92, 374, Parson A, 853, 859 Pertl C, 705, 742
403, 580, 588, 591, 595, 597, Parson GJ, 500, 563 Pertot WJ, 589, 660
598, 658, 660, 661, 662, 761, Partida-Rivera M, 926, 949 Pestritto ST, 370, 403
767, 786, 787, 793 Pascon EA, 374, 403, 512, 565, 587, 591, Peszkowski MJ, 332, 354
Osbon DB, 701, 742 659, 660 Peters DB, 615, 664
Osetek EM, 587, 659 Pashley D, 78, 92, 133, 135, 171 Peters DD, 79, 92, 212, 213, 257, 416,
Oshima H, 132, 171 Pashley DH, 47, 48, 49, 50, 51, 52, 53, 59, 516, 559, 566, 580, 588, 615,
Osorio M, 588, 660 60, 61, 79, 92, 102, 134, 167, 658, 660, 664, 675, 739, 854,
Ostrander FD, 11, 22 171, 264, 265, 266, 285, 286, 859, 923, 926, 949
Ostrander R, 698, 742 597, 662, 707, 743 Peters H, 26, 55
Ostravik O, 15, 22 Pashley EL, 47, 52, 61, 69, 789, 794, 885, Peters MCRB, 920, 923, 948
Ostro E, 870, 897 900 Peterson JN, 573, 656
Ostrom CA, 117, 169 Patel V, 652, 668 Peterson K, 746, 765
Oswald RJ, 52, 61, 593, 640, 661, 666, Paterson RC, 34, 56, 101, 102, 167, 871, Petersson A, 761, 767
781, 793 898 Petersson K, 761, 767
Ottl P, 117, 169 Path MG, 40, 52, 58 Peutzfeldt A, 929, 931, 949, 950
Ouhayoun JP, 670, 739 Pathomvanich S, 637, 666 Peyton FA, 48, 59, 117, 169
Ounsi HF, 516, 520, 522, 523, 566, 567 Patrinos A, 27, 55 Pfaffenrath V, 294, 320, 346, 350, 352,
Outhwaite WC, 48, 50, 59 Patterson CJW, 789, 794 356
Ouzounian ZS, 929, 949 Patterson RC, 873, 898 Pflug AD, 679, 740
Owadally ID, 705, 742 Patterson SM, 640, 666 Phaneuf RA, 871, 884, 898
Oye RK, 304, 336, 337, 351 Patterson SS, 15, 22, 68, 69, 89, 500, 532, Phillips C, 858, 860
Oynick J, 706, 743, 773, 792 563, 568, 759, 767, 884, 900 Phillips JL, 689, 740
Oynick T, 706, 743, 773, 792 Pattison GL, 110, 168 Phillips RW, 146, 173, 651, 668
Ozata F, 583, 658 Pawlak J, 101, 167, 865, 896 Piatelli A, 74, 90
Payne JA, 929, 949 Picard P, 348, 356
P Payne RC, 36, 57 Piccinino MU, 502, 564
Padilla R, 795, 840 Payne RG, 892, 902 Piccino AC, 922, 948
Pagavino G, 522, 523, 568 Pearson A, 358, 403 Pickard HM, 922, 948
Page PO, 52, 61 Pearson GJ, 129, 170 Picton DCA, 129, 170
Paladino T, 21, 23 Pearson HH, 692, 741 Pieper K, 524, 568
Palamara JEA, 608, 663 Pecora G, 700, 719, 722, 736, 742, 744, Pier M, 49, 59
Palat M, 778, 792 745 Pierce AM, 838, 839, 843
Pale R, 522, 523, 568 Pecora JD, 417, 559 Pileggi R, 522, 567
Palenik CJ, 83, 93 Pedicord D, 494, 562 Pilo R, 920, 929, 948, 949
Palik JF, 924, 949 Peeso FA, 781, 792 Pilot TF, 519, 567
Pallares A, 628, 665 Peikoff MD, 522, 567 Pilrero SJ, 35, 56
Pallasch TJ, 679, 699, 740, 742 Pekruhn RB, 15, 22, 670, 739 Pimenta F, 78, 92
Pimenta FC, 78, 92 Powis DR, 146, 173 Rapoport HM, 323, 352
Pindborg J, 189, 201 Poyton GH, 106, 168 Rapp GW, 576, 657
Pindborg JJ, 188, 201 Pozo MA, 290, 350 Rapp R, 38, 51, 57, 60, 863, 896
Pineda F, 224, 225, 258, 416, 417, 559, Pratten DH, 518, 520, 567 Rappaport HM, 512, 565, 589, 660
697, 741 Pravaz M, 576, 657 Raskin N, 330, 353
Pinero GJ, 503, 564 Prettl W, 551, 570 Rasmussen OC, 313, 314, 351
Pinholt EM, 698, 742 Price DD, 290, 291, 296, 297, 349, 350 Rastegar AF, 706, 743
Pini R, 551, 570 Price SB, 69, 90 Rath M, 346, 356
Pink FE, 926, 949 Price WA, 612, 664 Ratner EJ, 329, 353, 904, 912
Pinsaesdi P, 330, 353 Prichard J, 10, 22 Ratner JR, 329, 353
Pioncho P, 347, 356 Priebe WA, 11, 22, 179, 200, 358, 403 Rauch JW, 270, 286
Pipko DJ, 922, 948 Prietto P, 727, 744 Rauschenberger CR, 518, 521, 567
Pisano DM, 652, 668 Primack PD, 606, 609, 662, 663 Ravanshad S, 645, 666
Pisano JV, 518, 567 Primosch RE, 868, 881, 897 Ravn JJ, 808, 838, 841, 843
Pisanti S, 872, 898 Prinsloo LC, 136, 172 Ravnholt G, 926, 928, 949
Piskin B, 68, 78, 89 Prinz H, 572, 656 Rawlinson A, 214, 257, 584, 658
Pissiotis E, 593, 642, 661, 666 Pritz W, 639, 666 Ray BS, 283, 286
Pisson C, 178, 199 Prothero JH, 913, 914, 947 Ray HA, 583, 658, 758, 766
Pitoni C, 540, 541, 569 Provenza DV, 35, 56 Rayner JA, 864, 869, 896
Pitt Ford TR, 216, 257, 491, 494, 500, Pruett JP, 540, 548, 569 Read MS, 701, 742
516, 556, 561, 562, 563, 566, Pruett MP, 488, 489, 561 Reade PC, 40, 52, 58, 61, 78, 92
570, 583, 593, 655, 658, 661, Pucci FM, 2, 21, 29, 56, 409, 559, 751, Reader A, 30, 56, 389, 404, 679, 740
668, 693, 695, 705, 706, 741, 766 Reader CM, 612, 663, 759, 767
742, 743, 762, 767, 807, 808, Pugh RJ, 497, 563 Rechmann P, 554, 570
841, 874, 899 Pulver F, 881, 900 Redd PE, 43, 58
Pitts DL, 519, 567, 608, 641, 663, 666, Pumarola J, 586, 659 Reddy S, 77, 91
781, 793, 852, 859 Pupo J, 586, 659 Redmond AF, 857, 859
Plackova A, 45, 58 Purton DG, 929, 949 Ree DG, 511, 565
Plant CG, 124, 170 Pyner DA, 786, 793 Reeder OW, 48, 49, 50, 59
Plasschaert AJM, 580, 658, 849, 858 Reeh ES, 18, 23, 78, 91, 409, 559, 789,
Pliskin M, 63, 88 Q 794, 915, 947
Plummer TH, 176, 199 Qvist V, 35, 56 Rees RT, 284, 286, 346, 347, 356
Poalaghias G, 597, 662 Reeves JL, 330, 331, 341, 342, 345, 353,
Poe GS, 851, 859 R 355, 356
Pogrel MA, 216, 257 Raban LB, 314, 351 Reeves R, 97, 151, 167, 173, 865, 896
Pohto M, 50, 60 Radke RA, 926, 949 Regezi JA, 107, 168
Polhagen L, 181, 200 Rafeed RN, 637, 666 Regoli D, 176, 199
Pollack MH, 920, 948 Raghoebar GM, 729, 745 Reid LC, 524, 525, 568
Pollack R, 701, 742 Raibinowitz BZ, 889, 902 Reifferscheid G, 583, 658
Pollmann W, 346, 356 Raiden G, 925, 929, 949 Reig R, 29, 56, 409, 559, 751, 766
Pollock BE, 331, 354 Rakusin H, 530, 531, 568, 709, 710, 744 Reik L, 347, 356
Pomeranz HH, 225, 258, 416, 417, 559 Ram A, 501, 564 Reinhardt RA, 922, 948
Pontoriero R, 727, 744 Ram Z, 581, 658 Reis-Schmidt T, 264, 265, 285
Poort HW, 920, 923, 948 Ramadam AE, 358, 403 Reisis GI, 916, 917, 921, 947
Pope HO, 878, 900 Ramfjord SP, 684, 711, 740, 744, 756, 766 Reit C, 68, 78, 89, 557, 570, 764, 768, 923,
Porcelli RJ, 679, 740 Ramic Z, 74, 90 926, 949
Porkaew P, 643, 666 Ramil-Diwo M, 519, 567 Remeikis N, 187, 201
Portell FR, 693, 702, 741, 742, 923, 926, Ramirez SG, 329, 330, 353 Remeikis NA, 499, 518, 521, 563, 567
949 RamsT, 69, 90 Remington DN, 236, 238, 258
Portman P, 554, 570 Randow K, 915, 947 Reneman RS, 47, 59
Posada A, 400, 404 Ranly DM, 52, 61, 876, 877, 878, 885, Rengelstein D, 861, 896
Posewitz A, 331, 354 886, 887, 899, 900, 901 Replogle K, 679, 740
Pouladakis TK, 377, 404 Ranney RR, 46, 58 Requa-Clark B, 674, 739
Poulsen WB, 548, 569 Ranstrom G, 78, 91 Resouza YG, 178, 200
Pountney SK, 101, 102, 167 Ranta H, 68, 69, 74, 75, 78, 89, 91, 759, Rethman S, 719, 744
Powell BJ, 79, 92 767 Retief D, 133, 171
Powell CS, 873, 874, 898 Ranta K, 68, 69, 89, 759, 764, 767, 768 Reuben HL, 736, 745
Powell GL, 122, 169 Ranta M, 764, 768 Reuben M, 871, 884, 898
Powell SE, 482, 560, 789, 790, 793 Raphael D, 499, 563, 702, 742 Reuter JE, 915, 947
Powell W, 636, 666 Raphael KG, 346, 347, 356 Reuterving CO, 78, 79, 92, 759, 766
Powers JM, 486, 561 Rapisarda E, 550, 569 Reynolds MA, 497, 563
Reynolds OE, 283, 284, 286, 310, 351 Rollings I, 885, 887, 899, 901 Rushton J, 251, 258
Reynolds RL, 864, 896 Rolsetin I, 416, 559 Rushton JG, 328, 330, 353
Reznik JB, 790, 794 Romanus EM, 47, 59 Russel D, 325, 353
Rice RT, 586, 646, 649, 659, 667 Romond C, 650, 667 Russel HL, 318, 352
Rich JJ, 847, 858 Rose AHR, 583, 658 Russel T, 707, 743
Richards AG, 223, 257 Rose L, 916, 947 Russell CM, 147, 173
Richardson J, 132, 171, 913, 947 Rosen D, 187, 201 Rutberg M, 78, 91
Richman MJ, 493, 562, 703, 742 Rosen H, 922, 926, 948, 949 Ruthberg M, 133, 171
Rick G, 198, 201 Rosen S, 77, 91, 502, 564 Rutledge RE, 650, 668
Rickert UG, 581, 658 Rosenberg ES, 67, 88, 788, 793 Rydin E, 923, 926, 949
Ricketson E, 575, 657 Rosenberg L, 595, 661 Rydinge E, 78, 91
Rickoff B, 212, 213, 257 Rosenberg PA, 35, 56, 650, 667, 922, 948
Ricks L, 609, 663 Rosenfeld EF, 499, 563 S
Ridell A, 839, 840, 843 Rosenquist B, 735, 745 s-Gravenmade EJ, 885, 901
Riedel H, 40, 53, 57 Rosenstiel SF, 147, 173 Sabala CL, 480, 482, 535, 539, 560, 569,
Rifkin A, 889, 892, 902 Rosentritt M, 929, 931, 949, 950 785, 789, 790, 793
Rifkin BR, 707, 743 Rosini S, 74, 90 Sabes WR, 878, 899
Riis DN, 929, 950 Roskelley C, 608, 663 Sabiston CB, 69, 90
Riley RR, 246, 258 Ross IF, 918, 919, 921, 948 Sadler ES, 885, 901
Rilo B, 929, 949, 950 Ross RS, 919, 948 Sadrian R, 895, 902
Ringel AM, 15, 22 Rossman LE, 729, 745 Safavi E, 705, 743
Ripa LW, 894, 902 Rossman SR, 11, 22, 358, 403 Safavi K, 63, 88, 640, 666
Rising DW, 591, 660 Rossomando EF, 178, 199 Safavi KE, 78, 92, 178, 199, 580, 587, 658,
Riso K, 69, 74, 90, 759, 767 Roth G, 337, 355 660, 764, 768
Rissmiller DJ, 299, 350 Roth WC, 474, 480, 560 Sagawa H, 75, 91
Ritchey B, 104, 120, 168 Rothier A, 586, 659 Saglie R, 110, 168
Ritchey BT, 163, 174 Rothman MS, 882, 900 Saguer M, 333, 334, 354
Ritchie B, 674, 739 Rotstein I, 18, 23, 251, 258, 516, 566, 787, Sahal S, 605, 662
Ritchie JM, 674, 739 793, 845, 850, 852, 853, 854, Saheehan RF, 31, 56
Rittman BR, 187, 201, 764, 768 856, 857, 858, 859 Sailer HF, 551, 570
Rivera E, 74, 75, 91, 915, 947 Rout PG, 690, 741 Saito K, 323, 352
Rivera EM, 499, 512, 520, 563, 565, 567 RovelstadGH, 138, 172 Saito S, 583, 658
Roahen JO, 396, 404, 584, 658 Rowan M, 540, 569 Saito T, 518, 519, 520, 521, 566, 567, 655,
Roane JB, 15, 22, 480, 482, 538, 539, 560, Rowbotham M, 289, 290, 336, 349 668
569, 632, 665, 785, 793 Rowe AHR, 18, 23, 216, 257, 612, 663, Sakhal S, 612, 613, 616, 664
Robbins SL, 165, 174 786, 787, 793 Sakumura JS, 922, 948
Roberts AC, 709, 743 Rowe NH, 51, 60 Salem JE, 710, 744
Roberts AJ, 329, 353 Rowman MB, 480, 560 Salimbeni R, 551, 570
Roberts AM, 329, 353 Roy A, 395, 404 Salins PC, 338, 355
Roberts DH, 680, 740, 916, 917, 947 Rozen TD, 324, 352 Salonen L, 670, 739, 761, 767
Roberts DL, 701, 742 Rubb NW, 137, 172 Salvesen R, 325, 353
Robertson PB, 122, 169 Ruben MP, 689, 740, 885, 901 Salzgeber RM, 502, 564
Robertson S, 279, 286 Ruben MR, 40, 53, 57 Samuel PR, 709, 743
Robertson WD, 855, 859 Rubin E, 165, 174 Samueloff S, 261, 285
Robinson C, 575, 657 Rubinstein RA, 736, 745 San Marco S, 516, 566
Robinson HB, 67, 89 Ruch TC, 283, 284, 286, 316, 351 Sandberg H, 64, 88, 396, 404
Robinson HBG, 110, 168 Rud J, 69, 90, 695, 707, 741, 743, 789, 793 Sanderink GCG, 516, 565
Robinson M, 332, 354 Rud V, 707, 743 Sandoval VA, 264, 285
Robinson SF, 727, 744 Ruddle CJ, 736, 745, 762, 768 Sandrik JL, 576, 657
Robison SF, 108, 168 Rudy TE, 299, 350 Sangnes F, 808, 829, 841, 842
Rocabado M, 320, 352 Rueggeberg FA, 486, 561 Sanheza I, 479, 560
Rodef F, 888, 901 Ruemping DR, 888, 901 Santamaria J, 722, 744
Rodrigues H, 66, 88, 110, 129, 144, 168, Ruiz-Hubard EE, 535, 569 Santana U, 929, 949, 950
170, 173 Rule DC, 746, 765 Santerre P, 652, 668
Roed-Petersen B, 839, 840, 843 Rulkerson MS, 522, 567 Santi E, 778, 792
Roels H, 709, 743 Rulli MA, 181, 200 Santini A, 104, 168
Rohde TR, 584, 658 Runnells RR, 82, 83, 92 Santos MD, 639, 666
Rohlin M, 374, 403 Runyon C, 326, 353 Sargenti AG, 492, 562, 586, 596, 622, 659
Rohrer MD, 82, 93 Runyun DA, 606, 609, 662, 663 Sarkar N, 929, 949
Roig-Greene JL, 647, 667 Ruprecht T, 416, 559 Sarnat H, 889, 902
Rolf KC, 920, 948 Ruse ND, 850, 853, 859 Satho T, 68, 69, 89
Sato J, 335, 355 Scrabeck JG, 134, 171 Shearer GJ, 852, 853, 859
Saunders EM, 78, 92, 525, 568, 580, 627, Scurria MS, 914, 947 Shearer T, 69, 89
628, 634, 636, 637, 658, 665, Seale NS, 872, 898 Sheats JB, 579, 657
666, 758, 766 Searle BN, 214, 257 Sheets CE, 922, 948
Saunders WP, 397, 404, 525, 568, 634, Searls FJ, 596, 662 Sheller B, 888, 901
636, 637, 645, 665, 666, 667, Searls JC, 117, 169 Shen W, 654, 668
704, 742, 758, 766 Sedgley CM, 759, 767 Sheon RP, 319, 352
Saunte C, 320, 352 Seelig A, 117, 124, 169, 170 Shi JN, 524, 568
Saupe WA, 926, 949 Segal E, 132, 171 Shih M, 77, 91
Sauveur G, 254, 258 Segal H, 78, 92 Shillinburg H, 416, 559
Saw LH, 636, 665 Segerstad LHA, 78, 91 Shillinburg HT, 922, 948
Sawusch RH, 868, 872, 897 Segerstrom N, 69, 90 Shimauchi H, 177, 199
Saxena A, 488, 540, 561, 569 Seghi R, 850, 856, 858 Shindell E, 69, 90
Sayegh FS, 863, 866, 868, 878, 895, 896, Seidbergh BH, 225, 258, 416, 510, 559, Ship JA, 259, 285, 312, 351
902, 915, 947 564 Shirasuka T, 584, 587, 659
Scarfe W, 359, 403 Seidler B, 472, 559 Shively J, 586, 659
Scarlett M, 81, 82, 92 Sekine I, 655, 668 Shoaf HK, 52, 61
Schaeffer LD, 52, 61 Sekine Y, 694, 741 Shoha RR, 223, 257
Schafer E, 79, 92, 474, 488, 491, 560, 561, Sela J, 149, 173, 873, 898 Shoji S, 888, 901
580, 658 Selbst AG, 20, 23 Short JA, 77, 91
Scheetz JP, 911, 912 Selden HS, 198, 201, 284, 286, 532, 568, Shovelton DS, 865, 896
Scheinin A, 50, 60 697, 736, 741, 745 Shovlin F, 517, 566
Scherer W, 778, 792 Selig A, 416, 559 Shugars DA, 914, 947
Scheynius A, 34, 56, 69, 90 Seltzer S, 35, 56, 64, 76, 78, 88, 91, 96, Shugars KA, 586, 659
Schilder H, 66, 88, 160, 174, 178, 199, 102, 110, 114, 115, 138, 149, Shulman B, 376, 378, 404
512, 525, 565, 568, 575, 576, 150, 155, 167, 168, 173, 174, Shulman CA, 926, 949
612, 613, 615, 616, 621, 622, 330, 353, 483, 512, 560, 565, Shulman ER, 888, 901
657, 664, 788, 793, 915, 929, 572, 573, 577, 583, 586, 589, Shum L, 27, 55
947, 949 656, 657, 658, 659, 660, 785, Sicher H, 138, 172, 310, 311, 351
Schindler WG, 852, 854, 859 793, 862, 865, 870, 872, 896 Sidoli GE, 929, 949
Schiott CR, 678, 740 Sen BH, 63, 68, 78, 88, 89, 759, 766 Siebel W, 35, 56
Schllingburg HT, 922, 948 Senia ES, 107, 168, 316, 351, 502, 564 Siegel RL, 133, 171
Schneeberger G, 178, 199 Senia S, 254, 258, 485, 561 Siegert R, 304, 311, 351
Schneiderman ED, 698, 742 Senia SE, 77, 86, 91, 93 Sierashi SM, 417, 559
Schnell FJ, 926, 949 Senzer J, 52, 61, 593, 661 Sieraski S, 374, 403
Schnieder L, 196, 201 Sepic AO, 482, 485, 560, 561 Siew C, 79, 82, 92
Schnurr RF, 284, 286 Seraji MK, 512, 565 Sigel MJ, 36, 57
Schomberg PJ, 331, 354 Serene TP, 474, 488, 540, 560, 561, 569 Sigurdsson A, 643, 666
Schour I, 119, 124, 138, 169, 170, 172 Serper A, 589, 598, 660, 662 Silberstein SD, 324, 352
Schow SR, 698, 701, 742 Sessle BJ, 292, 296, 348, 350, 356 Silva LA, 588, 660
Schroder A, 868, 897 Setchell DJ, 915, 920, 926, 947, 949 Silva LAB, 588, 660
Schroder U, 871, 883, 897, 900 Seto BG, 474, 560 Silverberg M, 176, 199
Schroeder HE, 28, 55 Setterstrom J, 79, 92 Silverlade LB, 243, 258
Schroff FR, 163, 174 Seymour RA, 716, 744 Silverstein WH, 922, 948
Schulman SM, 689, 740 Shabahang S, 522, 523, 567, 829, 842 Simard-Savoie S, 678, 740
Schumacher JW, 643, 666, 759, 767 Shaber EP, 329, 353 Simlin DR, 605, 662
Schuster GS, 49, 59, 102, 167, 707, 743 Shafer W, 181, 183, 188, 200, 201 Simmons JJ, 264, 285
Schuurs AHB, 761, 767 Shah HH, 65, 68, 69, 88, 89 Simon DG, 339, 340, 355
Schwartz EA, 882, 900 Shah HN, 68, 78, 89 Simon HK, 709, 743
Schwartz FS, 546, 569 Shalla CI, 50, 59 Simon J, 108, 168, 669, 675, 739
Schwartz O, 833, 836, 842 Shannon IL, 945, 950 Simon JH, 181, 200, 756, 766
Schwartz RS, 773, 779, 792 Shapiro IM, 593, 661 Simon JHS, 232, 235, 258, 482, 511, 520,
Schwartz S, 17, 18, 19, 22, 142, 172, 221, Shapiro S, 577, 657 560, 565, 567, 759, 766, 767
257, 673, 739 Sharav Y, 324, 352, 863, 896 Simon M, 650, 668
Schwartz SF, 358, 403 Sharpe PT, 26, 55 Simon WJ, 692, 741
Sciaky I, 872, 898 Sharwy M, 138, 172 Simone DA, 291, 296, 350
Scott AC, 633, 636, 663, 665 Shaw BF, 299, 350 Simons D, 341, 355
Scott D, 50, 60 Shaw DW, 888, 9011 Simons DG, 292, 299, 304, 330, 338, 338
Scott GL, 494, 562 Shawley AL, 588, 660 339, 340, 341, 350, 355
Scott J, 149, 173, 297, 350 Shear M, 181, 194, 200, 201 Simons J, 607, 663
Scott NJ, 150, 173 Shearer AC, 516, 565 Simons LS, 299, 304, 330, 338 339, 340,
Sternbach RA, 208, 256 Sutherland JK, 406, 559 Tarnvik A, 65, 88
Sternberg RN, 35, 56 Sutton J, 397, 404 Tarsitano JJ, 210, 256
Steuer P, 36, 51, 57 Sutton T, 608, 663 Tashjian AH, 178, 199
Stevens R, 759, 767 Suzuki K, 517, 566 Tatakis DN, 178, 199
Stewart CM, 347, 356 Suzuki M, 119, 160, 169, 174, 868, 897 Tatoian G, 595, 661
Stewart FP, 49, 59 Suzuki S, 862, 873, 896 Tau CH, 189, 201
Stewart GG, 505, 564, 583, 658 Svare CW, 915, 922, 947, 948 Tay FR, 874, 899
Stewart RE, 107, 168 Svec TA, 15, 22, 501, 564 Taylor AC, 50, 60
Stock C, 492, 562 Sveen OB, 873, 898 Taylor B, 864, 869, 896
Stock CJR, 501, 502, 564, 779, 792 Svirsky JA, 198, 201 Taylor J, 606, 662
Stock K, 553, 570 Swaid S, 325, 353 Taylor PE, 43, 58, 176, 198
Stockdale CR, 692, 741 Swan N, 701, 742 Taylor PP, 887, 901
Stoecke lD, 488, 561 Swanson K, 651, 668 Teel S, 6, 22, 939, 944, 950
Stokes AN, 405, 558 Swart JGN, 143, 172 Teles R, 74, 77, 91, 178, 199
Storms JL, 511, 565 Swartz B, 915, 947 Tell RT, 136, 172
Strachan D, 51, 60 Swartz DB, 748, 765 Ten Cate AR, 26, 36, 37, 55, 57, 181, 183,
Straffon LH, 878, 900 Sweet CA, 876, 889, 899 200
Strindberg LL, 746, 765 Sweet WH, 329, 331, 353, 354 Teo CS, 516, 565
Strindberg LZ, 574, 657 Swerdlow H, 115, 117, 120, 127, 168, 169, Tepel A, 474, 560
Strobach A, 650, 668 266, 286 Tepel J, 488, 561
Strom B, 77, 91 Swindle RB, 539, 569, 923, 926, 949 Teplitsky PE, 406, 494, 495, 501, 559, 562,
Strom H, 178, 199 Swolin-Eide D, 178, 199 564, 645, 649, 650, 667, 782,
Stromberg T, 67, 89, 556, 570, 758, 766 Sykaras SN, 107, 168 793
Stromberg U, 758, 766 Symons N, 149, 173 Tepmongkol P, 522, 523, 567
Struthers P, 194, 201 Szajkis S, 518, 567, 758, 766 Terrence CF, 329, 353
Strutz JM, 840, 843 Tetsch P, 690, 691, 741
Stryga F, 491, 561 T Teuscher GW, 882, 900
Stuart KG, 78, 91 Tagami J, 135, 171 Tew JM, 331, 354
Stump TE, 690, 741 Tagger E, 133, 134, 171, 588, 652, 660, Tfelt-Hansen P, 323, 352
Suarez CL, 124, 170 668, 889, 902 Thacker RW, 923, 926, 949
Subay RK, 870, 873, 897, 898 Tagger M, 133, 134, 171, 588, 589, 612, Tharuni SL, 548, 569
Suchina JA, 926, 949 633, 652, 655, 660, 663, 668, The SD, 499, 563, 789, 793
Suda H, 264, 285, 405, 499, 518, 520, 522, 758, 766 Theofilopoulos AN, 178, 182, 200
523, 558, 524, 563, 566, 567, Tahibana H, 375, 404 Thesleff I, 26, 27, 55
568 Taintor JF, 50, 59, 103, 104, 150, 168, 173, Thoden van, 78, 91
Sudmann E, 698, 742 761, 767 Thoden van Velzen SK, 232, 258
Sugawara A, 586, 587, 643, 653, 659 Takagi M, 874, 899 Thoma KH, 188, 201
Suhr B, 325, 353 Takahashi K, 38, 57, 143, 144, 172 Thomas HF, 26, 28, 36, 55, 57
Sukumaran VG, 548, 569 Takahashi T, 214, 257 Thomas J, 151, 173
Sulfaro MA, 329, 353 Takahazshi S, 123, 169 Thompson SA, 540, 541, 546, 548, 549, 569
Sullivan HR, 163, 174 Takata T, 177, 199 Thomsen BL, 163, 174
Sullivan J, 359, 403 Takato T, 694, 741 Thomsen LC, 791, 794
Sultan Y, 701, 742 Takayama S, 177, 199 Thomson BM, 178, 199
Sumi Y, 705, 742 Takeda FH, 553, 570 Thorsteinsson TS, 920, 948
Sumino R, 292, 296, 350 Takeuchi H, 701, 742 Thrasher EL, 700, 742
Summers L, 181, 200 Takeuchi K, 707, 743 Thrush DC, 251, 258
Summitt J, 136, 172 Takuma S, 157, 159, 174 Thummel KE, 911, 912
Sun Lin P, 505, 564 Talim ST, 264, 285 Thylstrup A, 877, 899
Sunada I, 517, 520, 522, 566, 567 Tamarut T, 517, 566 Tidmarsh BG, 45, 58, 405, 503, 558, 564,
Sunderman EJ, 223, 257 Tamburic SD, 871, 898 586, 597, 659, 662, 696, 741,
Sundh B, 915, 947 Tamse A, 511, 513, 565, 595, 661, 762, 788, 793, 915, 947
Sundquist G, 670, 739, 757, 759, 766, 768, 929, 949 Tidwell E, 516, 566
767, 916, 917, 947 Tan DE, 652, 668 Tilk MA, 925, 949
Sundqvist G, 65, 67, 68, 69, 74, 77, 78, 79, Tani-Ishii N, 74, 91, 178, 199 Titley KC, 850, 853, 859
88, 89, 91, 92, 176, 181, 198, Tanker JM, 512, 565 Tjan AHL, 121, 135, 147, 169, 171, 173,
200, 499, 500, 501, 563, 564, Tanner A, 74, 91 651, 652, 668, 926, 949
757, 764, 766, 768, 829, 842 Tanner M, 214, 257 Tobias RS, 124, 131, 145, 170, 171, 173,
Sundqvist GK, 65, 67, 68, 69, 88, 89, 90 Tanzer JM, 69, 90 580, 658
Sundstrom F, 916, 917, 947 Tanzilli JP, 702, 742 Tobon G, 103, 168
Sunquish G, 160, 174 Tao L, 49, 59, 135, 171 Toda T, 655, 668
Suter B, 783, 793 Tariq M, 346, 347, 356 Todd MJ, 650, 667, 923, 948
Toffaletti JG, 593, 661 Trowbridge HO, 39, 50, 57, 60, 97, 167, Van Mierlo BL, 704, 742
Tolas Ag, 679, 740 177, 199, 214, 257, 262, 263, Van Nieuwenhuysen JP, 670, 675, 739,
Toller PA, 181, 189, 200, 201 285 740
Tomes J, 865, 896, 914, 947 Trowbridge HT, 153, 174 Van Ossten MAC, 733, 745
Tonder KH, 41, 47, 50, 51, 52, 58, 59, 60 Trump GN, 52, 61 Van Steenbergen JM, 759, 767
Tonelli MP, 727, 744 Tsai-Fant T, 1, 21 Van Steenbergen TJM, 69, 90
Tonetti M, 65, 88 Tsaknis PJ, 589, 660 Van Surksum R, 764, 768
Topal R, 32, 56 Tsatsas BG, 36, 51, 57 Van Winkelhoff AJ, 68, 69, 89, 759, 767
Topazian R, 69, 90, 184, 200 Tseng CC, 719, 744 VanCura J, 187, 201
Torabinejad M, 65, 66, 74, 88, 90, 176, Tsingos N, 916, 917, 921, 947 Vande Voorde H, 514, 565
177, 178, 179, 181, 198, 199, Tsuji I, 655, 668 Vander Vyver PJ, 136, 172
200, 201, 502, 516, 520, 554, Tsuneda Y, 873, 899 Vander Wall GL, 891, 902
564, 566, 567, 570, 579, 584, Tsutsui F, 922, 948 Vanelli M, 522, 523, 567
587, 612, 620, 645, 649, 651, Tucker AS, 26, 55 Vanholder R, 709, 743
655, 657, 658, 659, 663, 666, Tucker D, 68, 69, 89 Vannini M, 551, 570
667, 668, 704, 706, 709, 742, Tucker JW, 483, 560 Varady P, 331, 354
743, 759, 766, 767, 773, 779, Tulip J, 551, 569 Varella C, 522, 567
792, 807, 808, 829, 841, 842, Turk DC, 297, 350 Vargo JW, 416, 559
874, 899 Turkenkopf S, 78, 91, 785, 793 Varques JA, 573, 656
Torbjorner A, 916, 917, 947 Turkun M, 78, 91 Vasirani SJ, 387, 404
Torek Y, 852, 859 Turkun SL, 583, 658 Vaughan VC, 797, 841
Torgeson WS, 297, 350 Turner CH, 872, 898, 916, 917, 923, 926, Vaughn RC, 117, 169
Toringoe Y, 342, 356 947, 949 Vecchiet J, 342, 356
Torinoe Y, 342, 355 Turner DW, 587, 659 Vecchiet L, 342, 355, 356
Torneck C, 157, 174, 758, 766 Turner JE, 650, 667 Veis A, 631, 665
Torneck CD, 34, 38, 52, 56, 57, 394, 404, Tuschiya H, 75, 91 Veison S, 78, 91
640, 666, 694, 741, 850, 853, Tusker S, 697, 741 Velling RJ, 894, 902
859 Twehous D, 338, 355 Venham LJ, 878, 900
Torneck CK, 585, 659 Tyndall D, 374, 403 Vera J, 926, 949
Torres JOC, 759, 767 Tyring SK, 333, 354 Verde JC, 331, 354
Torstensson B, 132, 171, 868, 897 Tziafas D, 111, 168, 593, 661 Verdelis C, 597, 662
Toselli P, 178, 199 Vermeersch AC, 871, 898
Toshiaki Y, 136, 172 U Vermilyea S, 602, 603, 662
Touw JJA, 69, 90 Ucer O, 589, 660 Vermulen S, 331, 354
Tovi F, 788, 793 Uchin RA, 530, 568, 719, 744 Vernillo AT, 707, 743
Trabert KC, 218, 257, 920, 923, 948, 949 Udin RD, 887, 888, 901 Vertucci FJ, 30, 56, 224, 225, 258, 416,
Tramer M, 347, 356 Udolph CH, 143, 144, 172 559, 588, 660, 697, 741, 923,
Trask PA, 881, 900 Ueda M, 705, 742 926, 949
Travell J, 279, 286, 338, 341, 355 Ulmansky M, 149, 173, 873, 882, 898, Vertucci RJ, 696, 741
Travell JG, 299, 304, 330, 338, 338 339, 900 Verunac JJ, 253, 254, 258
340, 341, 342, 343, 350, 355, Umemoto T, 707, 743 Vessey RA, 530, 568
356 Unterbrink G, 874, 899 Vestergaard Pedersen B, 163, 174, 800,
Trechsel U, 178, 199 Urist M, 876, 899 822, 827, 841, 842
Trepagnier CM, 499, 563 Ushiyama J, 518, 566 Via WR, 883, 900
Tripi TR, 550, 569 Uzeda M, 78, 92 Vickers ER, 347, 356
Troiano NF, 319, 352 Viemmas L, 584, 658
Tronstad L, 37, 50, 57, 60, 64, 67, 69, 74, V Vigil GV, 75, 91
76, 88, 90, 96, 97, 129, 131, Vah J, 45, 58 Villalobos RL, 482, 560
133, 148, 150, 155, 167, 170, Vajrabhaya L, 522, 523, 567 Villena F, 577, 657
171, 173, 174, 232, 258, 496, Valcke CF, 124, 170 Vire DE, 612, 636, 664, 665, 748, 766
563, 641, 666, 746, 751, 757, Valderhaug J, 181, 186, 200, 889, 902 Visscher MD, 50, 60
759, 762, 764, 765, 766, 767, Valdrighi L, 504, 564 Vissink A, 729, 745
768, 870, 872, 873, 877, 897, Validaty A, 500, 563 Vito A, 78, 91
898, 899, 903, 912, 915, 947 Valle GF, 50, 59, 761, 767 Vlemmas I, 588, 660
Trope M, 15, 16, 22, 50, 60, 63, 67, 88, Valli KS, 637, 666 Voelkel EF, 178, 199
232, 258, 417, 559, 584, 651, Van Cura JE, 622, 664 Volta GD, 323, 352
658, 668, 675, 740, 751, 758, Van Damme J, 178, 199 Von der Lehr WN, 516, 565
766, 788, 793, 836, 843, 915, Van der Burgt TP, 580, 658, 849, 858 Von Fraunhafer SA, 586, 659
947 Van der Stelt PF, 223, 257, 516, 565 Von Fraunhofer JA, 573, 582, 586, 656,
Troutman K, 864, 890, 896 Van Hassel HJ, 43, 47, 51, 58, 59, 143, 658, 659
Trowbridge H, 155, 174, 864, 896 144, 172 Von Konow L, 68, 69, 89
Voss A, 522, 567 Wang W, 654, 668 Welch FH, 147, 173
Vujanic G, 74, 90 Waplington M, 704, 742 Well D, 376, 404
Vuleta GM, 871, 898 Wardrop RW, 285, 286 Weller RN, 78, 92, 632, 636, 665, 666,
Warfringe J, 50, 60, 66, 88 689, 697, 740, 741, 926, 949
W Warnakulasuriya S, 243, 258 Wenckus CS, 916, 918, 947
Wadachi R, 499, 563, 694, 741 Warner GR, 163, 174 Wenger JS, 589, 660
Wade AB, 232, 258 Wartofsky L, 318, 352 Wennberg A, 103, 168, 588, 597, 598,
Waechter R, 639, 666 Warvinge J, 148, 173, 811, 842 660, 662
Wagenberg B, 727, 744 Wason CP, 333, 354 Wenneberg B, 313, 314, 351
Waggener DT, 359, 403 Watanabe LG, 707, 743 Wenner A, 146, 173
Wagner M, 573, 656 Watanabe M, 136, 172 Wepsie JG, 331, 354
Wahl P, 523, 568 Waterman PA, 179, 200 Werner H, 759, 762, 766, 768
Wahl T, 374, 403 Waters WE, 327, 353 Wernes JC, 885, 901
Wais FT, 179, 200, 358, 403 Watkins B, 69, 89 Wesselink P, 79, 92
Waite DE, 690, 741 Watkins BJ, 69, 90 Wesselink PR, 584, 658, 761, 767, 853,
Wakabayashi H, 401, 404 Watson CP, 333, 354 859, 926, 949
Wakely JW, 692, 741 Watson JF, 129, 146, 170 West J, 616, 664
Wakisaka S, 50, 60, 176, 198 Watson TF, 655, 668, 706, 743 West JD, 851, 854, 859
Walander U, 311, 351 Watt VR, 333, 354 West L, 359, 403
Waldenlind E, 324, 352 Watts A, 34, 56, 101, 102, 167, 871, 872, West LA, 605, 662
Waldman BH, 4, 21, 48, 50, 59 873, 898 West NM, 593, 661
Waldron C, 189, 194, 201 Wax AH, 916, 918, 947 Westesson PL, 315, 351
Walia H, 482, 486, 509, 552, 560, 561, Waxenberg S, 524, 568 Westrum LE, 43, 58
570, 773, 792 Wayman BE, 69, 74, 75, 90, 91, 503, 564, Whang SB, 926, 949
Walia HD, 518, 520, 522, 567 597, 662, 759, 766 Wheeler AH, 339, 355
Walker AE, 321, 329, 330, 335, 352, 353, Weatherred JG, 50, 60 Whitacre RJ, 680, 740
355, 516, 565 Weathers AK, 523, 568 Whitaker SB, 194, 201
Walker RI, 69, 90 Weaver K, 154, 174 White JH, 212, 213, 257
Walker RT, 417, 559, 637, 666, 693, 741, Webb EL, 119, 169 White JM, 552, 554, 570
790, 794 Webber DF, 150, 173 White KC, 133, 171, 873, 874, 898, 899
Walker S, 347, 356 Webber J, 530, 568 White PW, 518, 520, 522, 567
Walker TL, 497, 501, 563, 564 Webber RT, 650, 667 White RR, 500, 563, 573, 598, 656, 662
Walker WA, 573, 605, 639, 656, 662, 666, Weber CR, 512, 565 White S, 516, 566
790, 794 Weber DF, 36, 57 White UC, 329, 353
Wall PD, 290, 349 Weber J, 478, 560 Whitehead FI, 865, 896
Wallace JA, 262, 285, 406, 559, 674, 739 Webster AE, 592, 661 Whitford GM, 52, 61
Wallerstedt D, 916, 917, 947 Wedenberg C, 138, 163, 172, 174, 231, Whittaker E, 500, 563
Wallstrom JB, 179, 200 234, 258 Widerman FH, 649, 667
Walman JO, 522, 567 Wefel JS, 654, 668 Widmer RP, 878, 900
Walmsley AD, 495, 496, 562, 704, 742 Weichman JA, 19, 20, 23, 551, 569 Wiedermann P, 40, 41, 57
Walsh CL, 494, 562 Weiger R, 522, 523, 567, 759, 762, 766, Wiemann AH, 585, 659
Walsh JT, 551, 569 768, 850, 858 Wiess MD, 870, 872, 897
Walsh L, 231, 258 Weinberger B, 727, 744 Wigdor HA, 551, 569
Walter RG, 86, 93 Weine DM, 871, 897 Wilcko JM, 588, 615, 660, 664
Walters J, 74, 90, 178, 200 Weine FA, 819, 842 Wilcox LR, 190, 201, 585, 608, 646, 651,
Walton R, 48, 50, 59, 74, 75, 78, 91, 160, Weine FS, 223, 225, 243, 257, 258, 391, 659, 663, 667, 668, 764, 768,
174, 179, 190, 200, 201, 417, 404, 416, 492, 511, 514, 518, 854, 859
525, 559, 568, 651, 668, 670, 525, 535, 540, 541, 559, 562, Wilder-Smith PEEB, 216, 257, 704, 742
739 565, 567, 568, 569, 596, 605, Wildey WL, 485, 561
Walton RE, 40, 41, 53, 54, 55, 57, 58, 69, 612, 613, 616, 662, 664, 675, Willard RM, 878, 900
74, 75, 90, 91, 138, 172, 187, 690, 695, 732, 740, 745, 916, Willerhausen B, 587, 588, 660
201, 214, 257, 358, 360, 364, 918, 947 Williams AR, 495, 562
365, 366, 367, 368, 369, 385, Weiner N, 577, 657, 679, 740 Williams BL, 69, 90
388, 397, 403, 404, 494, 502, Weiner S, 179, 200 Williams EC, 49, 50, 59, 60
512, 540, 562, 564, 565, 569, Weinstock A, 35, 56 Williams JA, 710, 744
607, 663, 845, 852, 858, 859 Weinstock M, 34, 35, 56 Williams JF, 916, 947
Wang CY, 74, 91, 178, 199 Weisenbaugh J, 729, 744 Williams MJR, 43, 44, 45, 46, 58
Wang E, 486, 561 Weisenseel JA, 643, 666 Williams RG, 30, 56
Wang GY, 500, 563 Weisman MI, 213, 257, 716, 744, 852, Williams WT, 847, 858
Wang SL, 759, 767 853, 859 Willis WD, 296, 350
Wang SM, 74, 75, 91 Welander U, 371, 403 Willoughby AFW, 923, 926, 949
Wilson AD, 131, 146, 171, 173 Wynn W, 50, 60 Yu F, 488, 561
Wilson CA, 580, 658 Wysocki G, 188, 201 Yu J, 342, 355
Wilson EG, 674, 739 Wysocki GP, 197, 201 Yu SM, 178, 200
Wilson EL, 922, 948 Yu W, 488, 561
Wilson MP, 83, 93 X Yu XM, 292, 350
Wilson NHF, 516, 565 Xhonga FA, 115, 168 Yunus M, 338, 355
Wilson PR, 632, 665 Xia T, 69, 89, 90 Yusef H, 759, 766
Wilson RF, 500, 563, 705, 742 Xu YY, 524, 568
Windeler AS, 86, 93 Z
Wing K, 371, 403, 670, 739 Y Zabalegui B, 852, 859
Winter GB, 889, 902 Yacobi R, 892, 902 Zach I, 32, 56
Wirthlin MR, 83, 93 Yagiela JA, 384, 385, 404, 678, 680, 740 Zach L, 115, 117, 169
Wisniewski K, 47, 58 Yahya AS, 497, 563 Zacharisson B, 155, 174
Withers J, 107, 168 Yamada RS, 596, 662 Zachinsky L, 124, 170
Witherspoon DE, 698, 701, 742 Yamaga M, 78, 91 Zachrisson BU, 35, 56, 818, 820, 842
Wittrock JW, 118, 169 Yamaguchi M, 494, 562 Zachrisson E, 886, 901
Wlaton RE, 499, 563, 606, 662, 847, 852, Yamami T, 136, 172 Zackariasen KL, 551, 569
858 Yamamoto H, 873, 899 Zakariasen KA, 491, 561
Woda A, 347, 348, 356 Yamamoto K, 68, 69, 75, 89, 91, 762, 768 Zakariasen KL, 497, 551, 563, 569, 572,
Wolard RR, 573, 656 Yaman P, 920, 948 573, 580, 615, 656, 658, 664,
Wolch I, 15, 16, 22 Yamana M, 260, 285 923, 925, 949
Wolcott J, 474, 488, 560, 561, 636, 666 Yamani T, 136, 172 Zaki AE, 36, 57
Wolcott JF, 652, 668 Yamaoka M, 519, 567 Zalkind M, 850, 856, 858
Wolcott RB, 115, 168 Yamasaki M, 68, 69, 89 Zander HA, 124, 129, 170, 870, 871, 872,
Wolff HG, 283, 286, 310, 351 Yamashita Y, 518, 519, 566, 567 882, 897, 900
Wolfson EM, 577, 657 Yamauchi G, 915, 947 Zarb GA, 732, 745
Wollard R, 586, 659 Yamauchi Y, 65, 78, 88 Zardiackas LD, 518, 567
Wollard RR, 622, 664 Yanai-Inbar I, 78, 91 Zeagarelli E, 190, 201
Wong J, 620, 664 Yancich PP, 615, 664 Zeldow BJ, 16, 22, 417, 559, 574, 657,
Wong M, 474, 484, 560, 580, 584, 615, Yang SF, 499, 563 746, 765
658, 659, 664 Yang ZP, 759, 767 Zelikow R, 493, 562
Wong MT, 107, 168 Yanikoglu FC, 416, 559 Zerlotti E, 38, 57
Wong R, 66, 88 Yankowtiz D, 50, 60 Zerr MA, 397, 404
Wong TA, 499, 563 Yared GM, 581, 619, 620, 658, 664 Zervas P, 631, 665
Woo I, 26, 55 Yates J, 586, 659, 887, 901 Zettesqvist L, 138, 140, 172, 231, 258
Wood AWS, 110, 168 Yee FS, 573, 620, 629, 656, 664, 665 Zezell DM, 553, 570
Wood DM, 490, 561 Yee RDJ, 785, 793 Zhang C, 553, 570
Wood N, 194, 201 Yermish M, 64, 76, 88 Zhijie Y, 163, 174
Woodhouse BM, 593, 661 Yesilsoy C, 482, 500, 509, 560, 563, 588, Zhirong G, 107, 168
Woodworth J, 524, 568 589, 660 Zhu Q, 705, 743
Wooley LH, 524, 568 Yew SC, 417, 559 Zias J, 1, 21
Woolley L, 216, 257 Yguel-Henry S, 484, 561 Zidan O, 584, 587, 655, 659
Worth HM, 197, 201 Yip WK, 107, 168 Zilberman U, 871, 892, 897, 902
Worthington HV, 524, 568 Yoko I, 78, 92 Zilberman Y, 829, 842
Worthington RB, 803, 841 Yokoyama K, 694, 741 Zillich RM, 416, 559, 650, 667, 922, 948
Wourms DJ, 646, 667 Yoon YW, 335, 355 Zinman E, 21, 23
Wrbas KT, 861, 896 Yoshiba K, 872, 887, 898, 901 Ziontz M, 102, 110, 115, 138, 149, 167,
Wright BA, 189, 201 Yoshiba N, 872, 887, 898, 901 168, 173
Wright ER, 78, 92, 580, 658 Yoshida M, 68, 69, 89 Zmener O, 524, 568, 586, 588, 589, 659,
Wright FA, 878, 900 Yoshikawa M, 655, 668 660, 925, 926, 949
Wu M, 79, 92, 759, 766 Yoshikawa R, 66, 88 Zoger B, 915, 947
Wu MK, 584, 658, 761, 767, 926, 949 Yoshimine Y, 875, 899 Zotterman Y, 261, 285
Wu NY, 524, 568 Yoshioka T, 405, 523, 558, 568 Zubriggen T, 505, 564
Wu Wang C, 759, 767 Yosioka T, 524, 568 Zucker KJ, 573, 656
Wuchenich G, 704, 742 Yoto I, 872, 898 Zuolo ML, 540, 569
Wuehrmann AH, 11, 22, 179, 200, 221, Young MA, 866, 897 Zyskind D, 854, 859
257, 358, 403 Young RF, 331, 354