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A 29-year-old male comes to your office with complaints of periodic bloody diarrhea
with mild abdominal pain for 1 month. He had these symptoms before but it resolves on
its own. He also has mild joint pain in his knees and ankles for 6 months. Also, she
noticed painful oral lesions. During the physical examination, you have found erythema
nodosum on her ankles and two aphthous ulcers approximately 1x1 cm in her mouth
which are mildly tender. You ordered colonoscopy which shows patchy rectosigmoid
inflammation with normal rectosigmoid mucosa 'skip areas' and the biopsy revealed
noncaseating granulomas. Which of the following is most likely diagnosis in the patient?
A. Ulcerative colitis
B. Crohns disease
C. Infectious gastroenteritis
D. Sarcoidosis
E. Behet's disease
Explanation:
The correct answer is B. This patient most likely has Crohns disease based on the
symptoms (of periodic bloody diarrhea with mild abdominal pain over several years,
mild joint pain in his knees and ankles for 6 months) physical examination (erythema
nodosum on her ankles and two aphthous ulcers approximately 1x1 cm in her mouth
which are mildly tender) and colonoscopy findings (shows patchy rectosigmoid
inflammation with normal rectosigmoid mucosa 'skip areas' and the biopsy revealed
noncaseating granulomas).
Ulcerative colitis (A), Infectious gastroenteritis (), and Behet's disease (E) are not
associated with biopsy finding - noncaseating granulomas.
Sarcoidosis (D) is not associated with the symptom of bloody diarrhea and rectosigmoid
inflammation.
In an orthotopic heart transplant, the recipient's heart is replaced by the donor heart;
placing the donor heart to the right of the recipients heart within the chest cavity is
known as a heterotopic heart transplant (C).
Ischemic stroke and transient ischemic attacks are seen more commonly with
transplantation than other cardiac surgeries (D).