Escolar Documentos
Profissional Documentos
Cultura Documentos
(REVIEW OF CONCEPTS)
OUTLINE
I. General concepts of Anatomy and Physiology
II. Skeletal System9
III. Muscular System
IV. Integumentary System
V. Nervous System
VI. Circulatory System
VII. Respiratory System
VIII. Digestive System
IX. Endocrine System
X. Urinary System
XI. Reproductive System
GENERAL CONCEPTS
Anatomy- structures, parts
Physiology- functions
Cell Division
1. Mitosis- replicates their own kind (cell division)
2. Meiosis- reproductive cells
Transport Mechanism
1. Diffusion- spreading out of molecules from areas of higher concentration to areas of lower
concentration
-“Downhill” phenomenon
Simple- no carrier needed (passive)
Facilitated- with a carrier
2. Osmosis- movement of solvent from areas of higher to lower concentration
Functions of Bones
1. protect delicate organs
2. encloses the bone marrow (productions of RBCs)
3. levers where body movements are performed
Structure of Bones
A. Macroscopic/Gross
-Compact/Hard
-Spongy
B. Microscopic
-Organic substances (collagen) - resilience of bone
-Inorganic substances (calcium and phosphate) - hardness
Ossification
- formation of bones/ maturation
1. intramembranous (clavicle and skull)
Clavicle (first to undergo ossification but last to ossify; most commonly fractured long
bone)
2. intracartilaginous/endochondral (all long bones except clavicle)
manubriosternal angle of
Louis (T4-T5)
body
xiphoid
T4-T5- carina (trachea)- most sensitive part of tracheabroncho
Child Adult
(33 vertebrae) (26 vertebrae)
Cervical 7 7
Thoracic 12 12
Lumbar 5 5
Sacral 5 1
Coccygeal 4 1
g. ribs (24bones)
true ribs (7pairs)
false ribs (5pairs)
floating ribs (2pairs)
Types of Joints
A. According to FUNCTION
1. synarthrodial- without movement
Examples: suture, gouphoses (socket of the teeth)
2. amphiarthrodial- slightly movable
Example: sacroiliac joint (expanded during pregnancy)
3. diarthrodial- freely movable joint
Examples: hips (acebulofemoral joint), shoulder (glerohumeral joint)
B. According to GENERAL TYPE
1. bone and socket- universal joint; allow movement in many directions
2. condyloid- allows movement in two directions and in a circle
3. hinge- allow movement in one plane
4. pivot- allows rotation but no other movement
5. saddle/sellar- two U-shaped surfaces allow movement in two directions and in a circle
6. plane/gliding- allow bones to make small sliding movements from side to side
Relaxin- make the ligaments and joints lax
THE MUSCULAR SYSTEM
Myology- scientific study of muscles
Muscles- compromise 40-50% of the total body weight
-produce moment
-generates heat
-give shapes
Types of Muscles
1. Skeletal Muscle- striated and voluntary
2. Cardiac Muscle- striated and involuntary
3. Smooth Muscle- nonstriated and involuntary
Types of burns
Electrical burn is the most devastating and catastrophic type of burn. This type of burn
is commonly results into an amputation.
“Tip of the iceberg” phenomenon occurs on electrical burn. It means that the extend of
the damage is not seen
Dermis burn is more painful than the epidermis burn because in the dermis there are
nerves
Grafting
1. autograft- own skin/self
2. homograft/allograft- some species (cadaver’s skin)
3. xenograft/heterograft- different species\
Spinal Cord- provides a vital communication link between the brain an the
body by way of paired spinal nerves that arise from it
Gray matter contains the cell bodies of motor neurons
White matter contains axon that relay messages between the brain and peripheral
nervous system
Neurons- cells in nervous system
When cortex get irritated, it can lead to seizure
During the 3rd month of fetal life, formation of spinal cord=vertebral column
In adult, spinal cord ends at L1-L2
Lumbar tap/puncture is injected at L4-L5 (safest level)
Blood components/elements
Red Blood Cells (Erythrocytes)
-supply oxygen to all body cell
-biconcave, without nucleus
-Normal lifespan: 120days (4months)
-Normal values: 5,000,000/cu mm (male)
4,500,000/cu mm (female)
-packed with the protein hemoglobin
Iron-bone marrow
-liver (ferritin)- stored form
Heme-bilirubin (metabolism of lipids and fats)
Erythropoeisis- RBC formation
During the 1st weeks of life, RBC formation are in the yolk
sac; 3 to 6 weeks in the lymphoid tissue (spleen); 6months
onwards in bone marrow
Vitamin B12 (cyanocobalamin) and Folic Acid are needed for
RBC maturation
White Blood Cells (Leukocytes)
-play a vital role in defending the body against infections by pathogens
-Normal Values: 5,000 to 10,000/cu mm
Groups of WBC
A. Non Granular
WBC- produce by
lymphoid tissue
B. Granular
WBC- produce by
bone marrow
Platelets (Thrombocytes)
-important in blood clotting
-cell fragments that lack a nucleus
-formed in the bone marrow
-prevent blood loss
-Normal Values: 200.000 to 500,000/cu mm
Clotting factors (14 clotting factors)
Clotting factor VIII deficiency can lead to Hemophilia A (classic Hemophilia
Clotting factor IX deficiency can lead to Hemophilia B (Christmas Hemophilia)
Blood Groups
Types Agglutinogens Agglutinins
(Antibodies)
Blood type O -- Anti A and Anti B
(universal donor)
Blood type A A Anti B
Blood type B B Anti A
Blood type AB A,B --
(universal
recipient)
Blood type O
Blood type AB
Airflow
larynx (voicebox)
trachea (windpipe)
-production of voice
-start of lower respiratory
-phonation
tract
1. thyroid cartilage
-16-20 cartilagenous
-Adam’s apple
rings pipe that extend to
2. cricoid cartilage (C6)
larynx to bronchus
(inferior: intubation/
-up to T4 to T5
tracheostomy)
-divided into Right and
3. epiglottis
Left primary bronchus
-prevent food going to trachea
Carina- very sensitive to
to prevent aspiration
coughing reflex
Laryngitis- hoarseness of
voice
secondary (lobar)
segmental bronchus
respiratory bronchiole
alveolar sac
alveoli
-functional unit
Gas Exchange
B. ACCESSORY ORGANS
1. Pancreas- retroperitoneal near greater curvature
-Exocrine (with duct)pancreatic enzyme
-Endocrine (without duct)Islets of Langerhans
Glucagon
Alpha cells
Beta cells
Insulin
Delta cells
Somatostatin
2. Liver- right hypochondriac area
- heaviest organ; 2nd largest organ
Liver Functions
CHO metabolism
a. converts glycogen into glucose
b. converts glucose to glycogen or triglycerides
Lipid metabolism
a. store triglyceride
b. synthesis of cholesterol
CHON metabolism
a. converts toxic ammonia (NH4) to urea
b. symthesis of plasma proteins
Removal of drugs/hormones
Excretion of bilirubin
Synthesize bile salts (lipid absorption)
Phagocytosis
Activation of Vitamin D
Coverings of kidney
1. renal capsule- innermost covering; preserving shape
2. adipose capsule and renal fascia- hold the kidney in place
Renal pelvis- reservoir of most urine
Renal cortex- outer region which is light in color
Renal medulla- deep to the cortex which is a darker reddish brown area
Medullary Pyramid- triangular regions with a striped appearance
Renal Columns- an extensions of cortex-like tissue that separate the medullary
pyramids
Nephron- functional unit of kidney that produce a urine
Nephroptosis- dropping of kidney due to decrease fats
Urine Formation
Each nephron consists of a glomerulus and a renal tubule, comprising a Bowman’s
capsule, proximal and distal convoluted tubules, a loop of Henle, and a collecting duct.
Blood flows at high pressure through the capillaries of the Bowman’s capsule and only
small molecules are forced through the walls into the first part of the nephron. The filtrate
passes down the proximal tubule, which secretes further metabolites and salts and reabsorbs
water, sodium, essential salts, glucose and amino-acids into the blood. The loop of Henle and
distal tubule are concerned with the reabsorption of water and maintenance of the overall acid-
alkaline balance of the body. Unwanted salts, urea and water are left as urine.
Filtration of blood and formation of urine
1. Glomerular Filtration
2. Tubular Reabsorption
3. Tubular Secretion
Filtration- PUSH solute TOWARDS Bowman’s Capsule
1. Glomerular Hydrostatic Pressure (GHP)
- push toward capsule
-facilitate filtration
-55mmHg
2. Capsule Hydrostatic Pressure (CHP)
-push toward the glomerulus
-opposes filtration
-15mmHg
3. Blood Colloid Osmotic Pressure (BCOP)
-pulling pressure
-pulls toward glomerulus
-oppose filtration
-30mmHg
Net Filtration Pressure- must be >1 in order to filtration to occur
GHP - [CHP + BCOP]
Glomerulonephritis is the inflammation in the glomerulus manifested by
hematuria
Pyelonephritis is the inflammation of the kidney
Tubular Reabsorption
1. Proximal Convulted Tubulke
-most reabsorption occurs here
a. 100% GAL (glucose, amino acid, lactic acid)
b. 80-90% bicarbonates
c. 65% K and Na (with obligatory H2O reabsorption)
d. 55% Cl
2. Loop of Henle
-descending Loop of Henle- facultative H2O reabsorption
-thick ascending Loop of Henle- 90% reabsorption of Na, K, and Cl
3. Distal Convolated Tubule and Collecting Ducts
-reabsorption of Na and Cl
-distal ends responsive to Aldosterone and ADH
-facultative H2O reabsorption absorbs Na and absorbs H2O
Tubular Secretion
1. Proximal Convulated Tube
-hydrogen (pH)
2. Distal Convulated Tubule and Collecting Duct
-potassium and ammonia
The urinary bladder can store 600 to 800 mL of urine but there is an urge to urine if it is
300-400mL
THE REPRODUCTIVE SYSTEM
-The primary sex organs or gonads are the testes in male and ovaries in females. The gonads
produce sex cells or gametes and secrete sex hormone.
A. MALE REPRODUCTIVE SYSTEM
-The reproductive role of the male is to manufacture male gametes called sperm and
deliver them to the female reproductive tract
-The primary reproductive organs of the male are the testes or male gonads, which have
both exocrine (sperm producing) function and endocrine (testosterone producing) function
1. Penis
-designed to deliver sperm into the female reproductive tract
-the skin-covered penis consists of a shaft, which ends in an enlarged tip, the glans penis
-the skin covering the penis is loose, and it folds downward to form a cuff of skin, the
prepuce or foreskin.
-2 parts: body (organ of intercourse) and glans (highly sensitivity; increase blood flow)
The foreskin is surgically removed shortly after birth, by a procedure called circumcision
PENIS
Functions:
-reproductive organ (sperm)
-excretory organ (urine)
erectile tissues
sexual stimulation
severe contraction
erection/ejaculation
2. Scrotun
-rugated skin covered muscular pouch suspended from the perineum
Under the normal conditions, the scrotum hangs loosely from its attachments, providing
the testes with a temperature that is below body temperature. When the external
temperature is very cold, the scrotum becomes heavily wrinkled as it pulls the testes
closer to the warmth of the body wall
The scrotum, which provides a temperature about 3 degree Celsius, is necessary for
the production of healthy sperm
3. Testes
Leydigs cell-production of testosterone
Seminifirous tubules- spermatozoa (production of sperm)
4. Epididymis- responsible for conduction of sperm from the testis to the vas deferens
-20 ft long; start of maturation (12-20 days); 64 days—maturation of sperm
Characteristics of Healthy Sperm
-60 to 70 million/ejaculation- 3cc (quantity)
-motility (quality)
-force of ejaculation