CELL BIO QUIZ 2

1. Fructose intolerance is caused by a defect in fructose kinase. 1, In this disease Fructose isnt
activated at all and 2, is Secreted in the urine
A 1 is true,2 not
B Both are not true
C 1 is false, 2 is true

2. What will not happen in the reaction between 3-phospho-glyceraldehyde to 3-

phosphoglycerate?
A.ATP hydrolysis
B. NADH produced
C. FADH produced
D. ATP is produced
E. A phosphate group is added

3. The steps of glycolysis between glyceraldehyde 3-phosphate and 3-

phosphoglycerate include all the following except
A ATP synthesis
B utilization of Pi
C oxidation of NADH to NAD+
D the formation of 1,3-biphosphoglycerate
E Catalysis by phosphoglycerate kinase
4. Which of the following are produced from the glycolytic breakdown of 1 mole of glucose
a. 2 moles of ATP, 2 moles of NADH, and 2 moles of pyruvate
b. 1 mole of ATP, 1 mole of NADH, and 1 mole of pyruvate
c. 1 mole of ATP, 2 moles of NADH, and 1 mole of pyruvate
d. 1 mole of ATP, 2 moles of NADH, 1 mole of pyruvate, and 3 moles of CO2
e. 1 mole of ATP, 2 moles of NADH, 2 moles of pyruvate and 1 mole of Co2

5. How many moles of ATP are produced from the breakdown of glucose to pyruvate by
glycolysis (assuming 1mole glucose, 2moles of pyruvate)
a. 8
b. 6
c. 4
d. 3
e. 2
6. The accumulation of citric acid will tend to
a. activate the glycolysis
b. inhibit glycolysis
c. not affect glycolysis
d. have opposite effects on glycolysis depending on the energy state
e. activate glycolysis and inhibit gluconeogenesis
7. The glycolytic breakdown of glucose will be stimulated when:
a. ATP levels are high
b. ATP levels are low
c. there is excess glucose in the blood
d .there is excess glycogen in the liver
e. there is excess fatty acids in blood

8. When ATP in hepatocytes rises, which of the following enzyme activity/ies fall/s?
1. hexokinase (not in liver)
2. phosphofructokinase-1
3. pyruvate carboxylase (GNG, +ATP)
4. pyruvate dehydrogenase (pyracetylcoA)
5. fructose-1,6-bisphosphatase
a. 1,2 b. 2,3 c. 1,4 d. 2,4 e. 1,3,5
9. The conversion of 1 mole of pyruvate to lactate yields __ moles of ATP
a. 30
b. 4
c. 2
d. 0
e. 8

10. In strenuous exercise the NADH need to be oxidized. What is the most important process
there?
A. pyruvate - lactate
B. pyruvate -- oxaloacetate
C. glyceraldehayde 3 p ---- 1,3 bis p glycerate
D. pep -- pyruvate

11. In glycogenolysis, the enzyme (i) breaks an (ii) bond to release a molecule of (iii).
A (i) glycogen synthase (ii) alpha 1-4 (iii) glucose
B (i) glycogen synthase (ii) alpha 1-4 (iii) UDP-glucose
C (i) glycogen phosphorylase (ii) alpha 1-6 (iii) glucose-6-phosphate
D (i) glycogen phosphorylase (ii) alpha 1-4 (iii) glucose-1-phosphate
E (i) debranching enzyme (ii) alpha 1-6 (iii) glucose-1-phosphate
12. Which of the following cells produce ATP only by glycolysis
a. hepatic cells
b. brain cells
c. kidneys cells
d. red blood cells
e. muscle cells

13. Which of the following statements is true?

1. glycolysis takes place in all human cells
2. the presence of oxygen is necessary for glycolysis
3. pasteur effect is the phenomenon by which oxygen indirectly induces
glycolysis
4. in mitochondrium containing cells the end product of glycolysis is pyruvate
5. red blood cells are capable of producing 4 mole of ATP from 1 mole of
Glucose
14. Which kind of energy does the muscle use?
A Glucose
B Fatty Acids
C Ketone bodies
D All are true
15. Which of the following statements are correct?
a. glycolysis can only occur under anaerobic conditions
b. glycolysis occurs in cells with no mitochondria
c. glycolysis is only undertaken for ATP production
d. all of the above are correct
e. all of the above are not correct
16. Gluconeogenesis
a. occurs exclusively in the cell cytosol
b. usually occurs in muscle
c. is important in maintaining blood glucose concentration during early starvation
d. is activated by fructose 2,6-bisphosphate
e. allows fatty acids to be converted into glucose in net amounts

17. Gluconeogenic enzymes include all of the following except

1. glucose-6-phosphatase is
2. pyruvate kinase
3. pyruvate carboxylase is
4. phosphoenolpyruvate carboxykinase is
5. fructose-1,6-bisphosphatase is
18. What becomes glucose
a. lactate
b. glycerol
c. pyruvate
d. acetyl-CoA
e. oxaloacetate

19. Mitochondrial O2 consumption decreases in the prescence of:

1. dinitrophenol
2. dinitrophenol +KCN
3. Oligomycin + dinitrophenol
4. oligomysin
5. Atractyloside
A2,4,5 B1,3 C3,4 D3,4,5 E1,2,5
20. Following glycogenesisglucose-6-P can be converted to?
-pyruvate
-glucose
-both
-neither

21. Precursor of glycogenesis

-ribose
-lactic acid
-erythrose
-glycerol
22. Glycogen
1 is stored in muscle
2 is stored only in hepatocytes
3 is fuel reserve for muscle cells
4 serve as a glucose reservoir for the maintenance of blood glucose
5 is converted by glucose-6-phosphatase in muscle cells
A 1,3,4 B 1,3 C 2,4,5 D 1,3,4,5 E 3,4,5

23. After two meals being in a well-fed state, which pathway will happen in the liver?
A Glucose-Glucose6P-Glycogen
B Glucose-Glucose1P-Glycogen
C Glycogen-Glucose1P-Citric acid cycle
D Glycogen-Glucose1P-Glucose
24. Glycogen phosphorylase:
1. is allosterically activated by AMP
2. is allosterically inhibited by ATP
3. is allosterically inhibited by AMP
4. is allosterically activated by ATP
5. is allosterically inhibited by glucose-6-phosphate
a. 1,2 b. 3,4 c. 1,2,5 d. 3,4,5 e. 3,5
25. Glycogen phosphorylase
1 catalyzes the conversion of glycogen into glucose-6-P
2 Catalyzes the conversion of glycogen into glucose-1-P
3 hydrolysis the alpha-1,6-glycosidic bonds in glycogen
4 hydrolysis the alpha-1,4-glycosidic bonds in glycogen
5 its genetic defect in muscle results in an elevated level of myoglobin, creatine kinase
and aldolase in the blood
A 1,2,4 B 2,5 C 1,4,5 D 2,3,4 E 1,3,5
26. When insulin in blood rises, which of the following enzyme activities increases
1. glucose-6-phosphate dehydrogenase
2. malic enzyme
3. pyruvate carboxylase
4. phosphoenolpyruvate carboxykinase
5. ATP-citrate lyase
a. 1,2 b. 2,5 c. 2,3,5 d. 1,4,5 e.1,2,5

27. Which of the following processes would be stimulated by excess blood sugar levels
in combination with insulin
1. glycolysis
2. the citric acid cycle
3. glycogenesis
4. glycogenolysis
5. ketone body synthesis
a. 1,3 b. 2,4,5 c. 2,3 d. 1,4 e. 1,2,3,5
28. Phosphoprotein phosphatase
1. is stimulated by cAMP
2. is stimulated by insulin
3. is inhibited by insulin
4. is inhibited by cAMP
5. is responsible for the inactivation of glycogen synthase
29. When glucagon in blood rises, which of the following enzyme acitivity/ies fall/s?
1. pyruvate kinase
2. pyruvate carboxylase
3. phosphoenolpyruvate carboxykinase
4. pyruvate dehydrogenase
5. phosphofructokinase-1
a. 1,2 b. 2,3 c. 3,4 d. 4,5 e. 1,5
30. 1 glucagon molecule how many cAMP molecules will be produced
a. many
b. 1
c. 2
d. 0
31. In which tissues is glucose not the main energy source:
A. Testis
B. Cornea
C. Breast (but do they mean lactating or non lactating, because then it is different)
D. Heart
E. muscle
32. What is the product after 6-phosphogluconate dehydrogenase enzyme works?
A. Phosphate
B. CO2
C. 5 carbon sugar
D. lactone

33. For 3 moles glucose metabolized through the PPP we get:

A. 1 mol CO2, 2 NADPH, 2 Ribose
B.3 mol CO2, 3 NADPH, 3 Ribose
C. 3 mol CO2, 6 NADPH, 3 mol ribose.
D. 3 mol CO2, 6 NADH, 2 mol ribose
34. Which of the following statements about the pentose phosphate pathway is correct
a. it provides precursors for the synthesis of nucleotides
b. it is reductive pathway, it consumes NADH (false)-products
c. it generates 36 mol of ATP per mole of glucose consumed
d. it is present in plants, but not in animals

35. The conversion of 1 mole of glucose to ribulose 5 phosphate yields __ moles of

NADPH
a. 5
b. 4
c. 3
d. 2
e. 1
36. What valid for the statement (a) vegetarian are healthy people (b) low diet of
protein doesnt effect the healthy
-statement 1 and 2 are both valid and 1 is a consequence of 2
-neither of the statement are valid
-statement 1 is valid and 2 is not
-statement 2 is valid and 1 is not
37. Phosphorylase kinase
1. is responsible for phosphorylation of glycogen phophorylase
2. is responsible for phosphorylation and activation of glycogen phosphorylase
3. consists of subunits, its structures is (alpha,beta,gamma,delta4)
4. its delta subunits are called calmodulin
5. hydrolyzes the phosphate groups of phosphorylase
a. 1,2,3,5 b. 2,3,4,5 c. 1,2,4,5 d. 1,2,3,4 e. 1,3,4
38. A patient presents with dizziness, fatigue,and tremors. A fingerstick test indicates a blood
glucose of 36 mmol/L. Of the allosteric activators of glycolysis in the liver, which one of the
following is the most important in allowing the liver to maintain a normal blood
glucose level?
(A) Citrate
(B) ATP
(C) Fructose 2,6-bisphosphate
(D) Glucose 6-phosphate
(E) Acetyl CoA

39. A 24-year-old woman complains of intermittent right upper quadrant pain that extends to the
inferior tip of her scapula. An ultrasound confirms your suspicion of cholelithiasis, and the
patient undergoes cholecystectomy. Analysis indicates gallstones containing bilirubin.
Measurement of metabolic intermediates, such as 2,3- bisphosphoglycerate and glucose 6-
phosphate, are elevated in her serum. A deficiency of which of the following enzymes most
likely led to her pigmented gallstones and release of these metabolites into the blood?
(A) Glucose 6-phosphate dehydrogenase
(B) PFK-1
(C) Pyruvate kinase
(D) Pyruvate dehydrogenase
(E) Pyruvate carboxylase
40. A teenager comes to the emergency room looking quite ill. Emergency medical services
report that this appears to be a suicide attempt using rat poison. The patient is in hypovolemic
shock from profuse vomiting and diarrhea. You note the strong smell of garlic from the patient.
Which one of the following correctly describes an action of this toxin?
(A) It inhibits pyruvate dehydrogenase.
(B) It activates pyruvate dehydrogenase.
(C) It reduces the concentration of pyruvate.
(D) It increases glutathione production.
(E) It enables gluconeogenesis to proceed.