Medication Therapy Management: A Comprehensive Approach

Table 20-2.Common Medical Conditions, Substance Use Disorders, and Medications Associated with Depressive Symptoms2, 5, 6
General Medical Conditions Substance use disorders (including intoxication and withdrawal) Drug therapy
Endocrine diseases

Hypothyroidism

Addison or Cushing disease

Deficiency states

Pernicious anemia

Wernicke encephalopathy

Severe anemia

Infections

AIDS
Antihypertensives

Encephalitis
Clonidine

Human immunodeficiency virus

Diuretics

Mononucleosis
Guanethidine sulfate

Sexually transmitted diseases

Hydralazine hydrochloride

Tuberculosis
Alcoholism Methyldopa

Collagen disorder
Marijuana abuse and dependence Propranolol

Systemic lupus erythematosus

Nicotine dependence Reserpine

Metabolic disorders
Opiate abuse and dependence (eg, heroin) Hormonal therapy

Electrolyte imbalance
Psychostimulant abuse and dependence (eg, cocaine) Oral contraceptives

Hypokalemia
Steroids/adrenocorticotropic hormone

Hyponatremia
Acne therapy

Hepatic encephalopathy
Isotretinoin

Cardiovascular disease
Other

Coronary artery disease

Interferon-1a

Heart failure

Myocardial infarction

Neurologic disorders

Alzheimer disease

Epilepsy

Huntington disease

Multiple sclerosis

Pain
 Parkinson disease

Poststroke

Malignant disease

Source: Teter CJ, Kando JC, and Wells BG. Major Depressive Disorder. In: DiPiro JT, Talbert RL, Yee GC, et al. Pharmacotherapy: A Pathophysiologic Approach, 8th ed. New York, NY: McGraw-Hill; 2014: Chap
77.

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