Natdanai Tachakamonsuk

Section 1104

Cocaine
Purpose of using cocaine
[1,2,4]
Cocaine is extracted from coca
leaves. The part that is extracted
is an alkaloid ester. Cocaine is
mostly used by methadone clients.
However, cocaine can be used in
medical as a treatment program. For
example, reducing illicit drug use,
decreasing criminal behavior, and
slowing the spread of the human
immunodeficiency virus (HIV). The
effect of using cocaine will make
user feel good, energetic, and
reduces tiredness. All of this effect will be occurred in the the
ventral tegmental area (VTA) of the brain. This area of the brain
will make you do things for reward and it will make you feel happy
when you do something. However, the long term effect of using
cocaine may lead to increasing the amount of dose. This will cause
a state of increasing irritability, restlessness, and paranoia in
user. Also it will cause the toxic in our blood vascular.

Chemical and physical properties[3]

Chemical properties
- C17H21NO4
- Molecular Weight: 303.358 g/mol
- 5 Hydrogen Bond Acceptor Counted
- 5 Rotatable Bond Counted
- Solubility: 1800 mg/L (at 22 C) in water, 1 g/6.5 mL alcohol; 1
g/0.7 mL chloroform; 1 g/3.5 mL ether; 1 g/12 mL oil turpentine;
1 g/12 mL olive oil; 1 g/30-50 mL liquid petrolatum.

Physical properties
- Melting point: 98 C
- Boiling point: 187 C
- Solid
- Colorless/white crystals or powder
 Natdanai Tachakamonsuk
Section 1104

Bibliography

1. Cocaine use by clients in methadone programs: Significance,

scope, and behavioral interventions . (2002, June 7). Retrieved
May 21, 2017, from http://www.sciencedirect.com/science/article/
pii/074054729190040H

2. Cocaine: Effects, Hazards & Warnings. (n.d.). Retrieved May 17,

2017, from https://www.drugs.com/illicit/cocaine.html

3. Cocaine. (n.d.). Retrieved May 21, 2017, from https://

pubchem.ncbi.nlm.nih.gov/compound/cocaine#section=Chemical-and-
Physical-Properties

4. Vascular disease in cocaine addiction. (2017, March 14).

Retrieved from http://www.sciencedirect.com/science/article/pii/
S0021915017301090