1. Lesion of lobules and small ducts all except?

A. Papilloma
B. Carcinoma
C. Cyst
D. Fibroadenoma

Answer D

Part Lesions
Lobules and terminal ducts Cyst
Sclerosing adenosis Small duct
papilloma Hyperplasia
Atypical hyperplasia Carcinoma

Large ducts Duct ectasia

Squamous metaplasia of lactiferous
ducts
Large duct papilloma Paget disease

Intralobular stroma Fibroadenoma Phyllodes tumor

Interlobular stroma Fat necrosis Lipoma

Fibromatosis Sarcoma

Robbins 9th, 1044

2. Most common site of breast carcinoma

A. Upper outer
B. Upper inner
C. Lower outer
D. Lower inner

Answer A

Approximately 50% of carcinomas are located in the upper outer quadrant, 10% in each of the remaining
quadrants, and about 20% in the central or subareolar region.

Robbins 9th, 1045

3. Zuska disease true all except ?

A. Squamous metaplasia of lactiferous ducts
B. recurrent subareolar abscess
C. inverted nipple is uncommon
D. Mostly seen in smokers
Answer C

Squamous metaplasia of lactiferous ducts is known by a variety of names, including recurrent subareolar
abscess, periductal mastitis, and Zuska disease.

Women, and sometimes men, present with a painful erythematous subareolar mass that clinically appears to
be a bacterial abscess.

In recurrent cases, a characteristic fistula tract often tunnels under the smooth muscle of the nipple and
opens onto the skin at the edge of the areola.

Many women have an inverted nipple, most likely as a secondary effect of the underlying inflammation.
More than 90% of the afflicted are smokers.

a relative deficiency of vitamin A associated with smoking or toxic substances in tobacco smoke alter the
differentiation of the ductal epithelium.

Robbins 9th, 1046

4. Lymphocytic Mastopathy true all except?

A. Mast cell abnormality
B. Aka Sclerosing Lymphocytic Lobulitis
C. Autoimmune disease
D. Associated with diabetes type 1

Answer A

Lymphocytic Mastopathy

(Sclerosing Lymphocytic Lobulitis)

Hard Palpable masses or mammographic densities.

It can be difficult to obtain tissue with a needle biopsy due to the dense collagenized stroma.

Atrophic ducts and lobules have thickened basement membranes and are surrounded by a prominent
lymphocytic infiltrate.

This condition is most common in women with type 1 (insulindependent) diabetes or autoimmune thyroid
disease and is hypothesized to have an autoimmune basis.

Its only clinical significance is that it must be distinguished from breast cancer.

Robbins 9th, 1047

5. cystic neutrophilic granulomatous mastitis caused by

A. Corynebacteria
B. Tuberculosis
C. Staphylococci
D. Fungi

Answer A
cystic neutrophilic granulomatous mastitis caused by Corynebacteria.

Robbins 9th, 1047

6. most commonly mutated gene in sporadic breast cancers

A. TP53
B. BRCA1
C. BRCA2
D. CHEK2

Answer A

TP53 is the most commonly mutated gene in sporadic breast cancers.

Robbins 9th, 1054

7. Most common type of breast cancer

A. Luminal
B. Basal
C. Her2 riched
D. All same frequency

Answer A

ER positive HER2 negative (50-65% of cancers)

Luminal

HER2 Positive (20% of cancers)

HER2 enriched

ER negative HER2 negative (15% of cancers)

Basal like

Robbins 9th, 1056

8. Nottingham Histologic Score is for

A. Breast carcinoma
B. Pancreatitis
C. Prostate cancer
D. Pheochromocytoma

Answer A

All types of invasive carcinoma are graded using the Nottingham Histologic Score.

Carcinomas are scored for tubule formation, nuclear pleomorphism, and mitotic rate and the points added
to divide carcinomas into grade I (well differentiated), grade II (moderately differentiated), and grade
III (poorly differentiated) types. Grade I carcinomas grow in a tubular pattern with small round nuclei and
have a low proliferative rate.

Grade II carcinomas may also show some tubule formation, but solid clusters or single infiltrating cells are
also present. There is a greater degree of nuclear pleomorphism and mitotic figures are present.

Grade III carcinomas invade as ragged nests or solid sheets of cells with enlarged irregular nuclei. A high
proliferative rate and areas of tumor necrosis are common.

Robbins 9th, 1094

9. most common benign tumor of the female breast

A. Fibroadenoma
B. Fibrocystic disease
C. Sclerosing adenosis
D. Papilloma

Answer A

Fibroadenomas are the most common benign tumor of the female breast. Most occur in women in their 20s
and 30s, and they are frequently multiple and bilateral.

The epithelial component is hormonally responsive and there is typically an increase in size due to
lactational changes during pregnancy.

Robbins 9th, 1069

10. most common stromal malignancy of breast ?

A. Leiomyosarcoma
B. Liposarcoma
C. Angiosarcoma
D. Chondrosarcoma

Answer C

Angiosarcoma is the most common stromal malignancy and can either be sporadic or associated with
radiation exposure or lymphedema.

Robbins 9th, 1070

11. most important prognostic factor for invasive carcinoma of breast in the absence of distant
metastases ?
A. Tumour size
B. Axillary lymph nodes
C. Tumour site
D. Histology

Answer B
Axillary lymph node status is the most important prognostic factor for invasive carcinoma in the absence
of distant metastases.

Robbins 9th, 1066

12. most common type of breast carcinoma to present as an occult primary ?

A. Tubular
B. Colloid
C. Lobular
D. Medullary

Answer C

Lobular carcinoma is the most common type of breast carcinoma to present as an occult primary. The
histologic hallmark is the presence of discohesive infiltrating tumor cells, often including signet-ring cells
containing intracytoplasmic mucin droplets. Tubule formation is absent.

Robbins 9th, 1065

13.