ABSTRACT

THE EFFECT OF SIMVASTATIN ON THE LEVEL OF TISSUE FACTOR

AND PLASMINOGEN ACTIVATOR INHIBITOR-1 IN PATIENTS
WITH TYPE 2 DM

Didik Supriyadi, Suradi Maryono, Sugiarto

Sub division of Hematology and Medical Oncology, Division of Internal Medicine
Faculty of Medicine Sebelas Maret University/Dr. Moewardi Hospital Surakarta

Background
Cardiovascular disease is responsible for about 70% case of death, especially
coronary heart disease due to premature atherosclerosis, which is a major cause of
morbidity and mortality of patients with type 2 DM. Thrombosis is a crucial stage of
development and progression of atherosclerosis and cardiovascular events in relation
to atherosclerosis. Tissue factor (TF) is the most powerful trigger of coagulation,
while plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. The
level of TF and PAI-1 increased in type 2 DM. Simvastatin showed antithrombotic
properties by pressing TF, as well as improving profibrinolysis by pressing PAI-1.
Objectives
This study aims to determine the effect of simvastatin on the level of TF and
PAI-1 in patients with type 2 DM.
Methods
The method used was a double blind randomized controlled trial, involving 24
pateints, 12 patients were given placebo in the control group and 12 pateints were
given simvastatin 20 mg/day. The study lasted for 6 weeks. Statitical analysis with
SPSS 1 for windows, significant if p<0.05.
Results
The results showed that the treatment group obtained a decrease in the level of
TF (pre vs post: 54,69 37,99 pM vs 31,62 1,58 pM; p=0,02) but did not change
the level of PAI-1 (pre vs post: 1,05 1,27 U/ml vs 1,29 1,08 U/ml; p=0,07). In the
control group was not found differences in the level of TF and PAI-1 before and after
treatment (TF pre vs post: 32,23 3,28 pM vs 34,34 7,86 pM, p=0,29; PAI-1 pre vs
post: 1,08 1,19 U/ml vs 2,1 2,67 U/ml, p=0,13).
Conclusions
Simvastatin decreased TF level but had no effect on PAI-1 level in patients
with type 2 DM.

Key words: simvastatin, tissue factor, plasminogen activator inhibitor-1, type 2 DM

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