MeanKineticTemperature(MKT)inStabilityStudies

Learn how to calculate the Mean Kinetic Temperature (MKT) in stability studies of pharmaceutical drugs.
Mean Kinetic Temperature is a useful tool used in pharmaceutical stability studies. It helps to calculate the degradation of stability sample.

Mean Kinetic Temperature can be defined as a single calculated temperature which degrades the same amount of the drug as degraded by the different
temperatures during the particular time period. MKT is not a simple arithmetic mean but is is calculated from the temperatures of a stability chambers.
Some software are available that stores the temperature from the stability chambers and also calculate the mean kinetic
temperature directly.

Related:Guidelines for Pharmaceutical Stability Study

Degradation of any drug totally depends upon its storage temperature. When tablets are stored in a stability
temperature, its temperature does not remain constant always. It varies up and down from the set
temperature.

Suppose we set a stability chamber at 30C but it shall be 29.4, 29.8 or 30.6 many times in the specified
period of time and we found the degradation of drug by 0.6% in that period. Now mean kinetic temperature
is calculated to determine the single temperature at which the drug would degrade by 0.6% in that period.

Also see:Climatic Zones for Stability Studies

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widelyread pharmaceutical
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