DEFINE THE FOLLOWUNG:

MIXOPLOIDY

CHAISMATA

1. Regarding this karyotype [47,XX ,+13] which of the following is the correct description of it :
a) Mosaic trisomy 13

Patau syndrome male

Edward syndrome male

Patau syndrome female

Edward syndrome female

2. Which one of the following has a haploid number of chromosomes?

a) primary spermatocyte

a) secondary spermatocyte

b) spermatogonia

c) Oogonia

d) None of the above

3. THE FOLLOWING STATEMENT IS CORRECT REGARDING GTG BANDING:

a) G-bands, by Tarium hydroxide, using Giemsa is the name of gtg

Constitutive heterochromatin resists degradation and is the only material left to bind with the Giemsa stain

the areas of inherited polymorphisms present on chromosomes 1, 9, and 16, resist degradation

The result is pale, almost ghostlike chromosomes

None of the above

4. Heating At pH 11.6:
a) is the method of digestion in Giemsa if the trypsin is not available

b) desaturating techniques in Giemsa 11

c) in combination with trypsin, only satellites of the acrocentric chromosomes will bind Giemsa

d) pericentromeric regions of all chromosomes will be stained

e) a and b is correct

5. Malsegreggation is:
a) Occur when both sister chromatid migrates to the same pole

When sister homologous chromomsomes migrate to the same pole

The product may include monosomy and trisomy

All of the above

The same process of premature sister chromatid separation

6. The following statement is correct regarding [47,XX,+21 /46 XX,]:

a) it is karryotyping of patient with down syndrome

it is karryotyping of patient with down syndrome ,mosaic

normal karryotyping with 46 chromosomes

the phenotypic feature of down syndrome is Lesley expressed in this patient

b and d is correct
 7. DSCR is a region in the chromosome that is:
a) PATAU SYNDROME CRITICAL REGION

THE AREA WHICH LOST IN DOWN SYNDROME

EDWARD SYNDROME CRITICAL REGION

ITS THE REGION OF THE CHROMOSOME WHICH IS RESPONSOBLE FOR MOLAR PREGNANCY

NONE OF THE ABOVE

8. CHIMERISM IS ABNORMAL KARRYOTYPING IN WHICH:

a) two different karryotyping with two different cell population from the same zygote present in the same patient

b) cancer patients considered to be chimerism

c) reverse twining is an example of chimerism

d) a and c is correct

e) all of the above is correct

9. MONOSOMIES IS:
a) THERE IS AN EXTRA COPY OF SINGLE CHROMOSOME

PATAU SYNDROME IS THE EXAMPLE OF MONOSOME

in 12000 live birth THERE IS 1 CASE OF MONOSOMY

[47,XX or XY,+13] IS AN EXAMPLE OF MONOSOMY

NONE OF THE ABOVE

10. IN BALANCED STRUCTURAL ABNORMAILTY:

a) There Is Loss Of Genes.

b) Detcted By Chance In Infirtilty Center

c) Present For The First Time In The Off Sbring

d) There Is Change In The Genotype But Not Phenotype

e) B & D Is Correct

Short notes:
write about all of the following
1. WRITE IN BREIF ABOUT CHOMATIN AND CROMATIN TYPES?

2. PRINICIPLE OF CHROMOSOMES BANDING, TYPES WITEIN DETIALS ABOUT TWO?

3. Why most of genetic disorder is maternal age dependent?

4. WRITE ABOUT FRAGILE SITE AND ITS ROLE IN GENETICS ABNORMALITY?

5. Describe how to reverse the staining pattern of g bands