Escolar Documentos
Profissional Documentos
Cultura Documentos
COMPARATIVE STUDY
a
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences,
Hacettepe University, Ankara, Turkey
b
Department of Developmental Biology, Harvard School of Medicine and Dentistry,
Harvard University, Boston, USA
c
Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Received 1 July 2012; received in revised form 20 September 2012; accepted 1 October 2012
KEYWORDS Summary The purpose of this study was to compare the short-term effectiveness of home
TMD; physical therapy (HPT) alone with that of manual therapy (MT) in conjunction with home physical
Manual therapy; therapy (MTeHPT) performed for four weeks in patients with temporomandibular disorders
Home physical (TMD). Forty subjects (nine males and 31 females; age, 18e72 years) with TMD were randomly
therapy; divided into two groups: HPT (n Z 20; five males and 15 females; mean age, 34.8 12.4 years)
Pain; and MTeHPT (n Z 20; four males and 16 females; mean age, 37.0 14.6 years). Pain intensity
Maximum mouth was evaluated at rest and with stress using a visual analogue scale (VAS). Pain-free maximum
opening mouth opening (MMO) was also evaluated. Mean change score (MCS) in VAS and the smallest
detectable difference (SDD) in pain-free MMO were measured over time. The results were ana-
lysed by MANOVA to evaluate the effects of treatment over time. At baseline, the groups did not
differ from each other with respect to VAS scores and pain-free MMO (p > 0.05). Within each
group, VAS with stress decreased (p < 0.001) and pain-free MMO increased (p < 0.001) over time.
Between groups, both time*treatment effect and treatment effect were significant for VAS with
stress (p < 0.001); however, only time*treatment effect was significant for pain-free MMO
(p Z 0.009). In the MTeHPT group, MCS for VAS with stress was 91.3% and SDD for pain-free
1360-8592/$ - see front matter 2012 Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.jbmt.2012.10.006
Effectiveness of manual therapy and home physical therapy in patients with temporomandibular disorders 303
MMO was 10 mm. Our results suggest that a four-week period of MTeHPT has a clinically signif-
icant effect on both pain and pain-free maximum mouth opening in patients with TMD.
2012 Elsevier Ltd. All rights reserved.
test (De Wijer et al., 1995; Naeije et al., 2009) were years) who received MT in conjunction with the HPT treat-
additional inclusion criteria for patients with anterior ment being the same as that prescribed to the HPT treat-
disc placement with reduction. ment group. MT included soft tissue mobilization (intra- and
3. Subjects with pain that was not related to acute extra-oral deep friction massage of painful muscles), TMJ
trauma, active inflammation or infection in the masti- mobilization (caudal and ventro-caudal traction, ventral
catory muscles/TMJ for at least three months were and mediolateral translation), TMJ stabilization (gentle
included. Forty subjects who met the inclusion criteria isometric tension exercises against resistance), coordina-
were enrolled as study subjects. tion exercises (guided opening and closing jaw movements),
cervical spine mobilization (traction and translation) and
post-isometric relaxation and stretching techniques for the
Exclusion criteria masticatory and neck muscles (Evjenth and Hamberg, 1980;
Rocabado and Iglarsh, 1991; Kaltenborn, 2003; Von Piekartz,
Subjects were excluded if they exhibited any of the 2005). MT was administered by another physical therapist
following signs or symptoms: disc displacement without who was clinically experienced and trained in TMD and MT
reduction, arthritis or TMJ arthritis according to categories and was not involved in subject recruitment, group assign-
IIb and III of the RDC/TMD (Dworkin and LeResche, 1992); ment, data collection or evaluation of the MT treatment. All
a history of chronic TMJ pain, clinical pathology, or previous subjects received MT three times a week during the four-
surgery related to the masticatory system or cervical spine; week treatment period. Each treatment session lasted
a history of TMD treatment within the previous three 30 min and was adapted individually to the needs of each
months; neurological or psychiatric disorders that could subject.
interfere with the procedure and intake of any medication Subjects in both groups were instructed to continue HPT
that affects the musculoskeletal system. for four weeks even if they were relieved of the pain.
Subjects selected for the study received unique identi-
fication numbers to conceal their names and designated
Outcome variables
groups. Based on a computer-generated randomization list,
each subject was allocated to one of the treatment groups.
All subjects were informed about the treatments; however, The outcome variables were pain intensity at rest, pain
the control treatment was not disclosed. In addition, intensity with stress and pain-free maximum mouth
subjects were instructed not to mention their group and opening.
treatment during clinical evaluation.
Baseline measurements were obtained before group Pain intensity
assignment by a physical therapist experienced in musculo- Pain intensity at rest was measured first, followed by with
skeletal rehabilitation and TMD and was blinded to the stress. Pain at rest was defined as pain intensity without
subjects groups. After four weeks of treatment, the patients stress and was measured in mandibular resting position
final assessments were recorded by the same physical thera- where the jaws were in the neutral position without any
pist. The physical therapist had no access to baseline data at contact between the mandibular and maxillary teeth and
the time of final assessment; furthermore, she was not any stress on the mandibular muscles.
involved in recruitment, group assignment or data analysis. Pain with stress was considered as pain intensity during
chewing. Subjects were asked to chew a stick of chewing
gum using both sides of their jaws for 60 s and immediately
Interventions rate their pain on a visual analog scale (VAS). As the tissues
became stressed, a response was elicited that determined
After baseline assessment, the HPT was explained to all the presence of TMJ pain (Michelotti et al., 2004).
subjects by the same physical therapist who performed the The VAS, which was used to record pain scores in this
baseline assessments. study, has been shown to be a reliable and valid instrument
for measuring pain intensity (Bijur et al., 2001). VAS scores
Group I: home physical therapy (HPT) were recorded at baseline and at the end of four weeks,
Group I comprised 20 subjects (five males and 15 females; i.e. after the last treatment session. Subjects were told to
age range, 20e63 years; mean age, 34.8 12.4 years) who place a vertical mark along the line to indicate their current
received only the HPT treatment, which involved subject pain status, ranging from no pain at all (0) to worst
education concerning the presumed aetiology of the pain, possible pain (100).
ergonomic advice, breathing exercises, relaxation tech-
niques, posture correction exercises and mandibular exer- Pain-free maximum mouth opening
cises such as active and repetitive assisted muscle Pain-free maximum mouth opening (MMO) was measured in
stretching, mouth opening and closing, medial and lateral millimetres at baseline and after the last intervention at
gliding and resistance exercises (Morrone and Makofsky, the end of the four-week period. Subjects were instructed
1991; Hanten et al., 2000; Michelotti et al., 2004). to open their mouth as wide as possible without causing
pain. The inter-incisal distance, i.e. the distance between
Group II: manual therapy in conjunction with home the maxillary and mandibular central incisors was measured
physical therapy (MTeHPT) using a millimetre ruler. Because repeated measurements
Group II also comprised 20 subjects (four males and 16 decrease the standard error of measurements (Kropmans
females; age range, 18e72 years; mean age, 37.0 14.6 et al., 2000), maximum unassisted mouth opening was
Effectiveness of manual therapy and home physical therapy in patients with temporomandibular disorders 305
with HPT in patients with TMD. The decrease in VAS and recommended by several authors for the rehabilitation of
improvement in pain-free MMO were significantly higher in the craniomandibular system because there is a known
the MTeHPT group than in the HPT group, indicating the relationship between posture and TMJ function (Komiyama
clinical effectiveness of MT-HPT treatment. et al., 1999; Wright et al., 2000). As per our study results,
Treatment approaches for TMD vary largely according to both the HPT and MTeHPT groups showed an improvement
different opinions based on its main aetiology. TMD can in VAS and pain-free MMO after four weeks of treatment.
have multiple causative factors, and the precise causes are Multifactorial models have been presented to explain
not clearly understood (Okeson, 1996; De Leeuw, 2008). the effect of MT (Gross et al., 2002; Kalamir et al., 2007; La
The signs and symptoms of TMD may be transient and self- Touche et al., 2009), which is commonly used to decrease
limiting over time, and most resolve without serious long- pain and restore mobility (Carmeli et al., 2001; Cuccia
term effects. Therefore, the early administration of et al., 2010; La Touche et al., 2011; Von Piekartz and
aggressive and irreversible treatments such as complex Ludke, 2011). Passive and active stretching of muscles or
occlusal therapy or surgery should be avoided (Okeson, range-of-motion exercises are performed to increase mouth
2003). A review on the management of TMD by List and opening and restore physiological mandibular movements
Axelsson (2010) found that surgery, occlusal adjustment (Evjenth and Hamberg, 1980; Rocabado and Iglarsh, 1991;
and electro-physical modalities had no effect in alleviating Ajimsha, 2011). A post-isometric relaxation technique was
pain related to TMD. The goals of managing TMD are best found to improve active mouth opening in a study (Blanco
achieved by using multidisciplinary approaches aimed at et al., 2006), while isometric tension exercises against
decreased pain and increased muscular coordination and resistance were performed for strengthening the mandib-
strength (McNeely et al., 2006; De Leeuw, 2008). ular muscles in another (Nicolakis et al., 2001, 2002).
Exercise and patient education have been shown to be Considering that pain is one of the main reasons for
effective in the management of TMD (Michelotti et al., patients seeking care (Dworkin et al., 1990; Okeson, 1996),
2004). Recently, Michelotti et al. (2012) stated that pain relief is a commonly used outcome measurement while
a patient education programme was slightly more effective assessing the effectiveness of interventions for TMD. In our
than an occlusal splint in decreasing muscle pain in patients study population, pain was the main symptom. Although
with TMD. In our study, we focused on subject education, VAS at rest and VAS with stress decreased over time in both
posture and mandibular exercises using HPT, which both groups, we found that the decrease was larger and the
groups received. Postural exercises have been effect of the four-week intervention was more significant in
the MTeHPT group. The decrease in VAS at rest and VAS Future research is necessary for investigating the long-term
with stress was clinically relevant as it exceeded the MCS in effects of MTeHPT and HPT alone in homogeneous TMD
VAS. Farrar et al. (2001) determined a 30% decrease in pain populations; these studies should include assessment of the
to be a clinically relevant difference in patients with subjects compliance levels as well.
chronic pain. In our study, MCS supported the clinical
effectiveness of treatment in both groups. In addition, it Conclusion
may be speculated that MT had positive contributions of
nearly 25% and 55% on VAS at rest and VAS with stress, In the short term, manual therapy in conjunction with home
respectively, in the MTeHPT group. physical therapy is more effective than home physical
With regard to the management of TMD, the restoration therapy alone for the treatment of TMD, particularly with
of physiological mandibular movement is essential. Pain- regard to decreasing pain and increasing pain-free
free MMO has been recommended as an outcome maximum mouth opening.
measurement in clinical trials on TMD (Carmeli et al., 2001;
Blanco et al., 2006; Cuccia et al., 2010) and has been shown
to be a reliable clinical sign (Kropmans et al., 1999). In our References
study, pain-free MMO significantly increased over time in
both groups; however, the effect of treatment over time Ajimsha, M.S., 2011. Effectiveness of direct vs indirect technique
was significantly greater in terms of an increase in pain-free myofascial release in the management of tension-type head-
MMO in the MTeHPT group in comparison with the HPT ache. J. Body Mov Ther. 15 (4), 431e435.
Aure, O.F., Nilsen, J.H., Vasseljen, O., 2003. Manual therapy and
group. According to Kropmans et al. (2000), 9 mm of SDD is
exercise therapy in patients with chronic low back pain:
used to determine the clinical effectiveness of an inter-
a randomized, controlled trial with 1-year follow-up. Spine 28
vention with regard to pain-free MMO in patients with TMD. (6), 525e531.
The increase in pain-free MMO after the treatment period Bijur, P.E., Silver, W., Gallagher, E.J., 2001. Reliability of the visual
was clinically relevant in the MTeHPT group as it exceeded analog scale for measurement of acute pain. Acad. Emerg. Med.
the recommended SDD score (4.4 and 10.0 mm in the HPT 8 (12), 1153e1157.
and MTeHPT groups, respectively), supporting the clinical Blanco, C.R., Fernandez-de-las-Penas, C., Xumet, J.E., et al.,
effectiveness of treatment in the MTeHPT group. 2006. Changes in active mouth opening following a single
Our findings are in agreement with those from other treatment of latent myofascial trigger points in the masseter
studies, indicating the effectiveness of MT with exercise in muscle involving post-isometric relaxation or strain/counter-
strain. J. Bodyw Mov Ther. 10 (3), 197e205.
patients with TMD. Nicolakis et al. (2001) demonstrated an
Carmeli, E., Sheklow, S.L., Bloomenfeld, I., 2001. Comparative
overall decrease in pain and improvement in function after
study of repositioning splint therapy and passive manual range
treatment in patients with anterior disc displacement with of motion techniques for anterior displaced temporomandibular
reduction. The treatment included manual joint distrac- disc with unstable excursive reduction. Physiotherapy 87 (1),
tion, disc/condyle mobilization and posture correction. 26e36.
Carmeli et al. (2001) compared the benefit of repositioning Cuccia, A.M., Caradonna, C., Annunziata, V., Caradonna, D., 2010.
splints and manual mobilization combined with exercise for Osteopathic manual therapy versus conventional conservative
anterior disc displacement and found mobilization with therapy in the treatment of temporomandibular disorders:
exercise more effective than splints alone. a randomized controlled trial. J. Bodyw Mov Ther. 14 (2), 179e184.
There are factors in this study that justify the De Leeuw, R., 2008. American Academy of Orofacial Pain: Guide-
lines for Assessment, Diagnosis, and Management, fourth ed.
improvements observed in the MTeHPT group. MT may
Quintessence Publishing, Chicago, pp. 131e141.
influence pain modulation through neurophysiological
De Wijer, A., Lobbezoo-Scholte, A.M., Steenks, M., Bosman, F.,
effects and may influence mobility through a neuromus- 1995. Reliability of clinical findings in temporomandibular
cular mechanism (Gross et al., 1996). A treatment session disorders. J. Orofac Pain 9 (2), 181e191.
tends to motivate a patient to be more compliant with the Dworkin, S.F., Huggins, K.H., Leresche, L., et al., 1990. Epidemiology
exercises. In our study, subjects in the MTeHPT group of signs and symptoms in temporomandibular disorders: clinical
attended 12 MT sessions by meeting the physical therapist signs in cases and controls. J. Am. Dent Assoc. 120 (3), 273e281.
three times per week. These sessions had positive effects Dworkin, S.F., LeResche, L., 1992. Research diagnostic criteria for
on the subjects. First, the physical therapist could assess temporomandibular disorders: review, criteria, examinations
the signs and symptoms at each phase of the recovery and specifications, critique. J. Craniomandib. Disord. 6 (4),
301e355.
process. Second, proper instruction and interaction by the
Evjenth, O., Hamberg, J., 1980. Muscle Stretching in Manual
physical therapist can exert positive psychological effects
Therapy, second ed. In: The Spinal Column and the Temporo-
on the subjects, thus alleviating their symptoms to mandibular Joint Alfta Rehab, Alfta, pp. 78e93.
a certain extent. Last, as stated by Feine and Lund (1997), Farrar, J.T., Young, J.P., LaMoreaux, L., Werth, J.L., Poole, R.M.,
those groups who received more treatment modalities 2001. Clinical importance of changes in chronic pain intensity
showed better results than those who received fewer. measured on an 11-point numerical pain rating scale. Pain 94
There are limitations to our study. First, the study design (2), 149e158.
did not allow for an evaluation period longer than four Feine, J.S., Lund, J.P., 1997. An assessment of the efficacy of
weeks. Second, we did not assess the subjects compliance physical therapy and physical modalities for the control of
level with the recommended treatments. Third, our TMD chronic musculoskeletal pain. Pain 71 (1), 5e23.
Fleiss, J.L., Levin, B., Paik, M.C., 2003. Statistical Methods for
subjects had myofascial pain with or without limited
Rates and Proportions, third ed. John Wiley & Sons, Inc,
opening and/or anterior disc displacement with reduction.
Hoboken, New Jersey.
308 A.B. Tuncer et al.
Friction, J.R., Schulman, E.L., 1987. The craniomandibular index: Medlicott, M.S., Harris, S.R., 2006. A systematic review of the
validity. J. Prosthet. Dent. 58 (2), 222e228. effectiveness of exercise, manual therapy, electrotherapy,
Gross, A.R., Aker, P.D., Quartly, C., 1996. Manual therapy in the relaxation training, and biofeedback in the management of
treatment of neck pain. Rheum. Dis. Clin. North. Am. 22 (3), temporomandibular disorder. Phys. Ther. 86 (7), 955e973.
579e598. Michelotti, A., Stinks, M.H., Ferrule, M., et al., 2004. The addi-
Gross, A.R., Kay, T., Hondras, M., et al., 2002. Manual therapy tional value of a home physical therapy regimen versus patient
for mechanical neck disorders: a systematic review. Man. Ther. education only for the treatment of myofascial pain of the jaw
7 (3), 131e149. muscles: short-term results of a randomized clinical trial. J.
Hanten, W.P., Olson, S.L., Butts, N.L., Nowicki, A.L., 2000. Effec- Orofac. Pain 18 (2), 114e125.
tiveness of a home program of ischemic pressure followed by Michelotti, A., de Wijer, A., Stinks, M., Ferrule, M., 2005. Home-
sustained stretch for treatment of myofascial trigger points. exercise regimes for the management of non-specific tempo-
Phys. Ther. 80 (10), 997e1003. romandibular disorders. J. Oral Rehabil. 32 (11), 779e785.
Kalamir, A., Pollard, H., Vitiello, A.L., Bonello, R., 2007. Manual Michelotti, A., Iodice, G., Vollaro, S., Steenks, M.H., Farella, M.,
therapy for temporomandibular disorders: a review of the 2012. Evaluation of the short-term effectiveness of education
literature. J. Body Mov. Ther. 11 (1), 84e90. versus an occlusal splint for the treatment of myofascial pain of
Kaltenborn, F.M., 2003. Manual Mobilization of the Joints. In: The the jaw muscles. J. Am. Dent. Assoc. 143 (1), 47e53.
Spine, fourth ed., vol. II. Olaf Norlis Bokhandel, Oslo, pp. 255e325. Morrone, L., Makofsky, H., 1991. TMJ home exercise program. Clin.
Komiyama, O., Cora, M., Aria, M., Asano, T., Kobayashi, K., 1999. Manag. Phys. Ther. 11 (2), 20e26.
Posture correction as part of behavioral therapy in treatment of Naeije, M., Kalaykova, S., Visscher, C.M., Lobbezoo, F., 2009.
myofascial pain with limited opening. J. Oral Rehabil. 26 (5), Evaluation of the research diagnostic criteria for temporo-
428e435. mandibular disorders for the recognition of an anterior disc
Kovacs, F.M., Abraira, V., Royuela, A., et al., 2008. Minimum displacement with reduction. J. Orofac. Pain 23 (4), 303e311.
detectable and minimal clinically important changes for pain in Nicolakis, P., Erdogmus, B., Kopf, A., et al., 2001. Effectiveness of
patients with nonspecific neck pain. BMC Musculoskelet. Disord. exercise therapy in patients with internal derangement of the
9 (4), 43. temporomandibular joint. J. Oral Rehabil. 28 (12), 1158e1164.
Kropmans, T.J., Dijkstra, P.U., Stegenga, B., de Bont, L.G.M., 1999. Nicolakis, P., Erdogmus, B., Kopf, A., et al., 2002. Effectiveness of
Therapeutic outcome assessment in permanent temporoman- exercise therapy in patients with myofascial pain dysfunction
dibular joint disc displacement. J. Oral Rehabil. 26 (5), 357e363. syndrome. J. Oral Rehabil. 29 (4), 362e368.
Kropmans, T.J., Dijkstra, P.U., Stegenga, B., Stewart, R., de Okeson, J.P., 1996. Orofacial Pain. In: Guidelines for Assessment,
Bont, L.G.M., 2000. Smallest detectable difference of maximal Diagnosis and Management. Quintessence Publishing Co, Chi-
mouth opening in patients with painfully restricted temporo- cago, pp. 113e184.
mandibular joint function. Eur. J. Oral Sci. 108 (1), 9e13. Okeson, J.P., 2003. Management of Temporomandibular Disorders
La Touche, R., Fernandez-de-las-Peans, C., Fernandez-Carnero, J., and Occlusion, fifth ed. Mosby, St Louis, pp. 371e393.
et al., 2009. The effects of manual therapy and exercise Rocabado, M., Iglarsh, Z., 1991. Musculoskeletal Approach to
directed at the cervical spine on pain and pressure pain sensi- Maxillofacial Pain. JB Lippincott, Philadelphia.
tivity in patients with myofascial temporomandibular disorders. Von Piekartz, H., 2005. Kiefer, gesichts- und zervikalregion. In:
J. Oral Rehab. 36 (9), 644e652. Kraniomandibulare Region-klinische Muster und Management.
La Touche, R., Paris-Alemany, A., von Piekartz, H., et al., 2011. Thieme Verlag, Stuttgart, pp. 168e225.
The influence of crania-cervical posture on maximal mouth Von Piekartz, H., Ludke, K., 2011. Effect of treatment of tempo-
opening and pressure pain threshold in patients with myofascial romandibular disorders in patients with cervicogenic headache:
temporal pain disorders. Clin. J. Pain 27 (1), 48e55. a single-blind, randomized controlled study. J. Cranio-
List, T., Axelsson, S., 2010. Management of TMD: evidence from mandibular Pract. 29 (1), 1e14.
systematic reviews and meta-analyses. J. Oral Rehabil. 37 (6), Wright, E.F., Demenech, M.A., Fischer, J.R., 2000. Usefulness of
430e451. posture training for patients with temporomandibular disorders.
McNeely, M.L., Armco, O.S., Magee, D.J., 2006. A systematic J. Am. Dent Assoc. 131 (2), 202e210.
review of the effectiveness of physical therapy interventions for Wright, A., Sluka, K.A., 2001. Nonpharmacologial treatments for
temporomandibular disorders. Phys. Ther. 86 (5), 710e725. musculoskeletal pain. Clin. J. Pain 17 (1), 33e46.