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ABSTRACT : SERUM ZINC CONCENTRATION AND TOTAL LYMPHOCYTE COUNT IN LIVER CIRRHOTIC PATIENTS
Nurman Sidiq Internal Medicine Department Faculty of Medicine Gadjah Mada University/Dr. Sardjito Hospital
Yogyakarta Year 2006, pages 39 Background. Patients with liver cirrhosis is susceptible for infection due to
deterioration of the immune system. Nutritional deficiency, especially Zinc deficiency, that is often found in patients
with liver cirrhosis causes deterioration in both specific and nonspecific immune system. In specific immune system,
Zinc deficiency decreases central and peripheral lymphocyte function and proliferation. Objectives. This study was
aimed to determinate serum Zinc concentration and its correlation with total lymphocyte count in liver cirrhotic
patients. Method. This cross-sectional study was conducted in Dr. Sardjito Hospital. Subjects were patients diagnosed
liver cirrhosis and regularly visited to Gastroenterohepatology ambulatory clinic or patients hospitalized in Internal
Medicine ward. Subjects were grouped into three classes of Child-Pugh, and were examined for serum Zinc
concentration and complete blood count count. Results. There were all 92 subjects consisted of 59 (72,0%) men and 23
(28,0%) women. Mean of age was 58,49 12,69, majority was within fifth decade. Subjects grouped into Child-Pugh
class A, B, and C were 35 (42,7%), 37 (45,1%) and 10 (12,28%) patients respectively. Mean of serum Zinc concentration
level was 11,4960 2,1221 mol/L, and Zinc deficiency found in 46 (56,1%) patients. The Serum Zinc level was not
correlated with Child-Pugh criteria. Mean total lymphocyte count was 1,5182 0,8085 103 cells/mmk, and
lymphopenia found in 51 (62,2%) patients. There was no statistically significant correlation of serum Zinc concentration
with total lymphocyte count in liver cirrhotic patients. Total lymphocyte count was correlated significantly to
hemoglobin level, leukocyte count, and thrombocyte count. It suggested that total lymphocyte count was resulted
from hypersplenism. Conclusion. The serum Zinc concentration level and total lymphocyte count decreased in liver
cirrhotic patients, but there was no statistically significant correlation. Keywords: Zinc specific immune system liver
cirrhosis
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7/17/2017 Hubungan antara kadar Zinc Serum dengan angka limfosit total pada penderita sirosis hati
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