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1. How does the liver glucose transporter differ from other glucose transporters in other tissues?
a. It concentrates Glc in the liver
b. It has a lower affinity for Glc than the others
c. It is induced by insulin
d. It co-transports Glc with Na+
10. A mutation in which glycogen enzyme will have the most severe effect on blood glucose?
a. Muscle phosphorylase
b. Glucose 6-phosphatase
c. Glycogen synthase
d. Liver phosphorylase
e. Branching enzyme
16. Which of the following is most likely to reduce fatty acid oxidation?
a. Phosphorylation of acyl-CoA synthetase
b. Feedback inhibition by acetyl-CoA
c. High levels of carnitine
d. High levels of malonyl-CoA
17. Methylmalonic academia is the accumulation of methylmalonic acid in the body. This can lead
to encephalopathy and is fatal if not treated. The most common cause is a genetic mutation
in methylmalonyl CoA mutase. What else might give rise to this disorder?
a. B12 deficiency
b. Mutation in acetyl-CoA carboxylase
c. Inhibition of thiolase
d. Biotin deficiency
20. Which best describes the synthesis of omega-3 fatty acids in liver?
a. Omega-3 fatty acids are synthesized from palmitate by elongation and omega-3
desaturase
b. Humans are unable to synthesize omega-3 fatty acids
c. Formation of the omega three double bond is catalyzed by the P450 enzyme, CYP183A
d. Formation of omega-3 fatty acids occurs only in peroxisomes
21. Cyclooxygenase is the critical enzyme in the synthesis of
a. Anandamide
b. PGE2
c. Thromboxane A2
d. LTD4
25. When a cell has adequate cholesterol, what prevents SREBP from transcribing cholesterol
biosynthetic genes?
a. Cholesterol is a negative allosteric modulator of SREBP
b. SREBP is anchored in the ER
c. PKA phosphorylates SREBP
d. An inhibitory protein binds to the enhancer sequence
29. A genetic mutation that impairs LDL receptor function will show
a. Liver toxicity due to lack of cholesterol
b. Extremely high levels of blood cholesterol
c. Low levels of all lipoproteins in blood
d. Inability to convert LDL to HDL
Answers
1. B
2. C
3. B
4. A
5. D
6. B
7. B
8. A
9. C
10. B
11. D
12. C
13. D
14. B
15. B
16. D
17. A
18. D
19. D
20. B
21. B
22. A
23. D
24. CDAB
25. B
26. D
27. A
28. C
29. B