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Anjana Brijith Johnson, Anu Sebastian, Anusha Sudulaguntla, Arpitha Chinnu Sabu*,
Swetha Meka and Basavaraj K. Nanjwade
The Oxford College of Pharmacy, Hongasandra, Bengaluru-560 068, Karnataka, India and
The Oxford Medical College, Hospital and Research Center, Attibele, Bengaluru-562 107,
Karnataka, India.
the factors affecting adherence, Forgetfulness, ignorance, aloneness, were found to be the
major cause of non-adherence followed by poverty and lack of transportation. Adherence of
the patient can be improved by establishing a good patient-provider relationship and giving
proper patient counselling to patient or their relatives.. Patients should be reminded to take
their medications at the right time, to come for follow up, to regularly measure BP and to
have proper diet.
INTRODUCTION
Adherence to (compliance with) a medication regimen can be defined as the extent to which
the patients take medication as given by the care providers or it refers to the willingness and
ability of an individual to follow health related advice properly, to medication as prescribed,
to attend scheduled clinic appointments, as well as to complete recommended follow-ups.[1]
Medication non-compliance is the failure or discontinuation of proper medication taking
without the concern of prescribed physician.[2] Adherence is also defined by World Health
Organization as the degree to which the persons behavior corresponds with the agreed
recommendations from a health care provider.
1. Social and economic factors: Time commitment, Cost of therapy and income, Social
support
2. Condition- and therapy-related factors: Disease factor; Therapy-related factors
identified include; Treatment complexity; Route of administration; Duration of treatment
period; Medication side effects; Degree of behavioral change required. Taste of
medication; Requirement for drug storage.[5]
1. Level of prescribing: Introduce a cooperative approach with the patient at the level of
prescribing. Whenever possible we include patients in decision making regarding their
medications so that they have a sense of ownership and they are provided partners in the
treatment plan. Simplify medication taking. Use the most simplified regimen as first choice
based on patient characteristics. Modification will have to be made to medication regimens to
reduce the frequency of administration and/or reduced the number of different medications or
replace with combination products.
include the medication regimen into his/her daily regimen (mainly the patient taking complex
drug regimens, those having accidental difficulties in adherence (e.g. elderly).
3) During follow ups: Schedule appropriate follow up. Monitor the patient medication
adherence during the follow ups. Assess adherence during consequent follow ups. Check the
adherence by various methods which may be dependent on patient As well as disease
characteristics. Check the effectiveness of medication adherence aids used, if any. This
should be done by physicians as well as by pharmacists. Identified difficulties and barriers
related to adherence, address the problems. Use fixed combinations (poly-pills) to reduce the
number of tablets.
They concluded that it was a valid and reliable measure of adherence to psychoactive
medications (Table 1).
The patient should be asked to respond to the statements in the questionnaire by circling the
answer which best describes their behavior or attitude towards their medication.[8]
Hypertension
Blood pressure or hypertension can be defined as the pressure exerted by the blood against
the arteries of the heart pumps blood through the body. Blood pressure readings are given as
two numbers, and the top number is called the systolic blood pressure. The bottom number is
called the diastolic blood pressure. For example, 120 over 80 (written as 120/80 mmHg).
Hypertension is the most common cardiovascular disease in the world. It affects a major
percentage of the adult population, hovering morbidity and mortality rates in both developed
and developing countries. The World Health Organization (WHO) accounts one eighth of all
deaths as being triggered by hypertension, which ranks it third as a cause of mortality
globaly.[9]
Hypertension is one of the global major cardiovascular diseases with increasing popularity,
frequency and complications. Patients are unaware about the disease, its treatment, severity
and complications. They have less knowledge on the drug regimen and lifestyle changes that
has to be brought by them. It is thus necessary to provide patient counselling on the three
basic areas such as disease, drugs, and lifestyle.
Identifying the current level of patients in the graph of medication adherence and providing
necessary advice to patients for better adherence can help in achieving optimal outcomes in
the treatment. As well as by providing patient counselling we can improve the patients
knowledge about the disease and drugs. Changes in lifestyle can improve the quality of life of
the patient. Patient healthcare professional relationship can be improved as well.
Many factors can cause blood pressure, including the amount of water and salt having in your
body, the condition of your kidneys, nervous system, or blood vessels, your hormone levels,
unbalanced diet, stress, physical inactivity, and stiffening of blood vessels due to ageing.
Inclusion Criteria
In-patients admitted in the general medical ward during the study period (6 months) who
may or may not be admitted for treatment of hypertension.
Patients with previously diagnosed conditions and are on prescription drugs.
Exclusion Criteria
Patients treated as out-patients
Patients treated without prescribed of drugs.
Pediatrics
Pregnant and Breast-feeding Women
Post-operative patients
Dental patients
Operation Modality
Step 1: Data collection: this includes getting consent of patient, collection of information
from patient case data file and assessing medication adherence by asking MARS
questionnaire. According to the scale Patient's that respond "NO" to questions 1-6 and 9-10
and "YES" to questions 7-8 are compliant (Table 1). Hence the score of each patient was
identified and tabulated based on first visit (Table 2). Also graph can be drawn based on the
score vs. number of patients falling in that score. From the graph we can identify the
percentage of patients who are adherent and non-adherent (Figure 6).
Score Adherence
0-3 Non-adherent
4-6 Partially adherent
7-10 Adherent
The demographic details, clinical characteristics and medication taking characteristics were
also analyzed(Table 3).[10]
Step 3: Reassessment: Second visit was made to the patient and the MARS questionnaire was
again asked (Table 1). The score was calculated based on the answers and the improvement
in adherence was identified (Figure 7).
Step 4: Data analysis: The data collected were analysed by descriptive analysis. The
summarised data only was entered into the worksheet in Microsoft Excel, and the graphs
were obtained.
The people of age group 60-69 showed more adherence compared to other age groups (Figure
1).
Our study showing Two third of the patients were unaware about the complications of
hypertension (Figure 2).
According to the data obtained, literates were found to be more adherent than illiterates
(Figure 3).
According to the occupation, Civil Servants and Unemployed people were found to be 100%
adherent (Table 5).
People who had hypertension from 1-5 years are found to be more adherent than those
patients who had hypertension of longer duration (Figure 4).
People living in county regions are found to show more adherence than those living in village
and urban regions (Figure 5).
Those patients who go for proper follow up showed comparatively more adherence. This
result shows that at least once a year follow up is sufficient for proper monitoring of patient
condition (Table 7).
Those patients who monitored their BP levels regularly showed more adherence than who
were irregular (Table 8).
Those who had a comorbid condition were found to be more adherent (Table 9).
Out of 150 patients only 53 patients showed adherence to medication, during the first visit
(Figure 6).
There is improvement in adherence after the first visit, as the patients who were non-adherent
decreased by 12.63%, partially adherent decreased by 25.3% and whose who were adherent
increased by 25.3% (Figure 7).
From Figure 8 it is evident that the major reason for non-adherence is forgetfulness,
aloneness and ignorance which makes 35.25%. The second leading cause is poverty,
followed by old-age inactivity.
DISCUSSION
We conducted a prospective observational study on medication adherence rating of
hypertensive patients to assess their medication taking characteristics in tertiary care hospital.
Although the medications are given to the patients, it may not be necessary that they comply
with the medication all the time as it is a symptom-less disease and patients probably forget to
take the medication or do not feel the need to take them. Considering all the factors and the
results obtained accordingly, the study can be compared or analysed based on results of other
similar studies.
Reviewing the demographic data, it was found that 45% of the patients were aged 60 69
years (Figure 1). This result is consistent with the study conducted by Papatya Karakurt, and
Magfiret Kas (53.6%). Patients above 70 years were found to be more adherent (90-100%),
whereas in the study conducted by Papatya Karakurt, and Ma gfiret Kas it was only 33.9%.
In our study, only 41% of the patients were females (Table 4). On the contrary Papatya
Karakurt, and Magfiret Kas study reported higher rates of hypertension in females (78%).
Males were more in number and showed comparatively more adherence than females in our
study.
It was found that the great majority of patients about two third of patients do not know about the
complications of hypertension at all (Figure 2). This is almost similar to the result obtained
by Papatya Karakurt, and Magfiret Kas where 99.1% people did not know about the
complications. This problem can be solved by conducting various healthcare programs, and
bringing awareness about prevention, risk factors and complications. Encourage people for
health screening at least once a year.
This study showed that there is significant relation between educational status and adherence
as illiterates were only 83% adherent while literate patients showed 92% adherence (Figure
3). A similar result was obtained in Papatya Karakurt, and Ma gfiret Kas Karakut study.
It was also found that 46% of patients had been suffering from hypertension for 1 - 5 years
(Figure 4). Similar figures for patients suffering from hypertension for 1 - 5 years were
reported by Papatya Karakurt, and Magfiret Kas(43.6%). This frequent result of 1 - 5 years may
be associated with the fact that hypertension is an asymptomatic disease.15 Patients who were
suffering from hypertension 1-10 years showed more adherence to medications. In the study
conducted by Papatya Karakurt, and Magfiret Kas it was found that the patients with a
longer history of hypertension (50.6%) tended more to take their medicine as prescribed.
Patients from urban area showed more adherence compared to those from village and county
(Figure 5). This is in accord with the result obtained by Papatya Karakurt, and Ma gfiret Kas
where people from village showed fewer adherences (34%). This result may also stem from
the difficulties of transportation for patients who live in rural areas or less accessibility.
It was found that 46% of the study participants did not comply with their diet (Table 6), which is
similar to the value obtained by Papatya Karakurt, and Ma gfiret Kas(47.35). This result may
be associated with the likelihood of patients not having had adequate and balanced nutrition
before the disease, which they found keeping a diet difficult, and/or that training by medical
staff was insufficient.
This result showing 37% of patients to have their blood pressures measured regularly
(Table 8), is similar to the rate of 46.3% reported by Papatya Karakurt, and Ma gfiret Kas.
But those who had there BP measured regularly were found to be 91% adherent.
Among the reasons for non-concordance (Figure 8), the grouping of forgetfulness,
aloneness, and negligence (35.2%) took the first place, which is in agreement to that of Papatya
Karakurt, and Ma gfiret Kas (49.3%).
CONCLUSION
From this prospective observational study, we came to the conclusion that the patients who
are 60 years and older are more adherent to their medication. This might be due to fear of
complications, and hope for improvement in patient condition. For elder patients, the family
members care about their health and provide necessary support for them or remind them to
take the medications, which helps in improved adherence to medications. Usually for patients
above 70 years the relatives only give the medication to the patient, as the elderly are
depended on them.
The awareness about the complication of hypertension, diet, follow up, regular measurement
of BP, medication related facts, and adverse effects can be provided to individual patients by
proper patient-provider interaction. When patients are aware of the complications they are
more likely to follow the advice of the prescriber to prevent its occurrence. Patient
counselling can be given to the patient, patient relatives or in written forms such as drug
cards, leaflets or sheets. Reminders about follow up and regular BP measures can help
improve adherence. The more interest the patient shows in the condition, the more chances
they follow a proper diet and medication. From this study we have seen the improvement in
adherence after patient counselling (Figure 7). Patient counselling sheet containing details of
disease, lifestyle modifications, and all necessary information related to drugs to be taken,
were translated to local language and distributed to literate patients. For illiterates, pictograms
of some advices were given for better patient understanding.
Forgetfulness, ignorance and aloneness are one of the major reasons for non-adherence
(Figure 8). The patient can set alarms, reminder notes, or organise which all drugs are to be
taken at which time. The family members can remind the patients.
Health care professionals can also remind the patients through letters, phone calls etc.
Patients who are busy with their occupation can pre-book appointments, make reminders for
clinic visits, and set apart time for monitoring their condition.
ACKNOWLEDGEMENTS
We wish to express our sincere gratitude to Prof. Dr. Padmaa. M. Paarakh Principal of The
Oxford College of Pharmacy, Bangalore for providing us an opportunity to do our project
works.
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