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  • Arthritis PRJ

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    Anil Pusala
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    Arthritis Prj

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    this is link to the project

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    © All Rights Reserved
    Baixe no formato PDF ou leia online no Scribd
    Sinalizar o conteúdo como inadequado
    9 visualizações16 páginas

    Arthritis PRJ

    Enviado por

    Anil Pusala
    this is link to the project

    Direitos autorais:

    © All Rights Reserved
    Baixe no formato PDF ou leia online no Scribd
    Sinalizar o conteúdo como inadequado
    de 16
    SCREENING‘OF ANISEEDS (Pimpinella anisum) FOR ANTIOXIDATIVE AND ANTIARTHRITIC ACTIVITIES Coats Thesis submitted to SRI SATHYA SAI INSTITUTE OF HIGHER LEARNING PORN LUC O MLNS LLCO M OMA OR MASTER OF HOME SCIENCE (Food Science and Nutrition) or rn A SCREENING OF ANISEEDS (Pimpinella anisum) FOR ANTIOXIDATIVE AND ANTIARTHRITIC ACTIVITIES Thesis submitted to SRI SATHYA SAI INSTITUTE OF HIGHER LEARNING in partial fulfillment of the requivements for the degree of MASTER OF HOME SCIENCE (Feed Science and Nutuition) DEPARTMENT OF HOME SCIENCE SRI SATHYA SAI INSTITUTE OF HIGHER LEARNING Anantapur Campus Anantapur — 515 001 (A.P.) MARCH 2011 CERTIFICATE 1 Thereb. certify that this thesis comprises the original work done by ate _A Privadatshini on“Screening of aniseeds (Pimpinella anisum) for gnnoxtunuve anu andarthritic activities” under my supervision as a part of the course W for the Degree of “Master of Home Science in Food Science and Niitrition” at Sri Sathya Sai Institute of Higher Learning, Anantapur Campus, Anantapur. pr Gest ian Place: Anantap Date 1613), ia, the traditional medicine, Ayurveda, ‘evolved more than 5000 years i ywledge transmitted orally ‘until it was written. down — the Vedas — around 1500 BC. It flourished in the ‘7th century, ‘Ayurveda focuses 00 disease prevention and health promotion, with an emphasis om et (riven, 2005) Examples of Ayurvedic use of herbs and spices for health effects include turmeric for jaundice, pasil to protect the heart, mace for stomach —jfections, cinnarnon t© stimulate cireulation, and ginger a5 the universal medicine, jn particular for relieving nausea and indigestion. Many of these herbs and spices ae used in Indian cooking 10 impart flavour, and significant quantities can be consumed in one meal Tt has Deen reported that such herbs and spices can supply reasonable quantities of nutrients 25 well, such as iron. It has been estimated that an qu adult in India oan eat as much as 4 & of turmeric daily, which could provide 80-200 mg/day of the bioactive component curcumin, Some Indians have been reported to eat as much as 50 g of garlic in a week (Sainani et al., 1979). ‘Natural products, including plants, animals and minerals have been the basis for treatment of human diseases. History of medicine dates back practically to the ‘existence of human civilization. The current accepted modern medicine or allopathy hhas gradually developed over the years by scientific and observational efforts of scientists, However, the basis of its development remains rooted in traditional .., and therapies. The history of medicine includes many ludicrous therapies. levertheless, ancient wisdom has been the basis of modern medicine and will remain Fi as one important source of future smedicine and therapeutics: The future of natural products drug di 3 am : 12 discovery will be more holistic, personalized and involve wise ‘use of anci 4 ent and modert therapeutic skills in a complementary manner so that ‘maximum ‘benefits can be accrued to the patients and the community (Patwardhan jnherent value aS well as potential toxicity of es the For cee : ruman eattt, has Bee recognized (Cox, 1994). Plants are Spemicals € , and wraditional sources of medication 1 large parts of worlds herbs, es have been used since ancient times PY physicians and at variety of human diseases, yet many of them need to pass 1980). A wide variety of moder controlled, ctinical experimentation (Pruthi jy and in mixtures have been extensively investigated in ical sciences 1° evaluate their chief as well as supplementary omnpementary and synergistic actions jn health and diseases (Aggarwal ef als gos Szallasi, 2005) ‘Albeit spices ate consumed in relatively small amounts, they are nevertheless consumed by large sections of population globally (Thimay amma etal, 1983) Diet has been recognized as a corner stone in the management of various disorders. Drug, diet and recently spices therapies are the major approaches used for treatment and control of diseases. Spices are the common dietary adjuncts that contribute to the taste and flavor of foods. Besides, spices are also known to exert several beneficial physiological effects including the antidiabetic influence. Dietary spices influence various systems in the body such as gastrointestinal, cardiovascular, reproductive and nervous systems resulting in diverse metabolic and. jhysiologic actions. Thus, spices provide us with ample health benefits and thus, help the body to fight against diseases such as cardiovascular diseases osteoarthritis, mental disease, cancer and diabetes mellitus (Ismail ef al., 2010). Spi : pices and herbs have been used throughout history as natural sources of flavouri : ing and for their preservative properties. They possess antioxidant 2 ity ‘because the i A ey contain chemical compounds (including the flavonoids, the terpenoids, lignans, sul fides, polyphenolics, carotenoids, coumarins: aponins, plant sterols Seeiinins andipihisids) wi 7 pihlaids) with biological activities that may provide therapeutic of spices limits their use (Craig, 1999). 1 significantly more so in tropical, oriental, Hispanie and the worlds ines (Kochhar, 1996)- Mesierranean o™ spices contain & huge range of phytochemicals that have proven health Dietary spices aoti-mutagenic, anti-inflammatory, ficial effects on human health via maintain human health by their antioxidative, benefits: chemopreventive, Gneslls anda wide nein 707 of putative bene’ on gastrointestinal, cardiovascular respiratory, metabolic, reproductive, ampe, 2003; Rao, 2003). By acting through a number of immune modulatory effects action peural and other systems (1 different mechanisms, the phytochemicals found in spices prevent and reverse many of the processes which underline chronic diseases. Most chronic diseases involve ferent processes, and spices frequently defend our bodies against specific several dit diseases by counteracting more than one of these pathological mechanisms. The ost important properties of phytochemical i od lipid modulators, plood-thinning agents, blood sugar regulators, include their role as antioxidants, anti- carcinogens, blo nicinflammatory agents, antimicrobial agents, toxin neutralizers, bioavailability enhancers, synergistic compounds and as triggers for gene activation. These properties make spices effective, preventive and therapeutic agents against some of the most serious chronic diseases, including cancer, heart disease, diabetes and Alzheimer’s disease (Scott, 2006). Dietary hypolipidemic spices, like curcumin, capsaicin, and garlic, were found to be beneficial in protecting the structural integrity and fluidity of erythrocytes under conditions of hypercholesterolemia and hypertriglyceridemia. oy ua this beneficial effect by correcting the altered cholesterol to phosphorus oe _° in hypercholesterolemic situation and by restoring a of pevtrooses in both hypercholesterolemic and Pi. ae (Kempsiah and Srinivasan, 2004). Platelets in role in hemostasis during damage to blood vessels and thrombosis s by formi y forming compact and adhesive aggregates. Compounds that counter «5 - cuminaldehyde, ewgenol> and zingerone in vitro snd oumin were also evidenced to have significant seation (Subramoniyam and Satyanarayana, 1989). that grows up to eighteen inches in height. ‘an annual herb to cre ana the Mediterranean regions it is now being grown all 1), Its flowers ate s feather shaped. The fruit of anise is oblong and grayish mall, yellowish white and Brow in umbels, Hype in color. sts ens pat that has 0 wide variety of medicinal as well as culinary its use dates aS far back as the ancient era. Different periods of time ses. In fact, ting used for different PUTPOSSS For instance, in the sev curing coughs’ and also Romans used it to control centh century saw anise anise was used as a remedy for ‘pad breath. In the sixteenth centur xy, owing to its feathery appearaness it was used often as bait to trap mice. ‘Due its popularity, anise WS listed as a taxable drug in www.ehealthy jand.com/author/admin/). the fourteenth century (hitp!/¥ Tn India, its grown 10 2 small extent a5 culinary herb. Anise possesses & sweet aromatic taste and emits, when crushed a characteristic aggreable odour, and The fruits ie used for flavoring food, confectionery, bakery products and beverages. are considered mild expectorant, stimulating, carminative, diuretic and diaphoretic, and are used in flatulent colic, in the preparation of asthma powders and in eteri i i rinary medicine, Alecholic extract of aniseed possesses fungicidal activity (Parry, 1962) Ani ee Heeeds contain variable amounts of fat, protein (18%) and crude fibre (12.25%), It also contai also contains carbohydrates, minerals and vitamins. Aniseeds are considered as mi ild expectorant, stimulating carminative and diuretic, Stimulatiing chief consti stituent of ani 4 f anise oil is anethole and is used as an ingredient in cough lozenges nati in combination with liquorice (Parry, 1962). 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