adrenal medulla neuroectodermal Anterior adrenal cortex mesodermal Superior: "bare area" of the liver. Medial: inferior vena cava The cells of Future medulla travel along the nerves of the Lateral: "bare area" of the right lobe of the liver. 6th to 12th segments into the developing cortical Inferior: peritoneum and 1st part of duodenum primordia. Posterior surface: Within the cortical tissue, the migrating cells proliferate Superior: Diaphragm. and differentiate into chromaffin cells at around the third Inferior : Anteromedial aspect of the right kidney month of gestation. The mesodermal component of the cortex is visible as Left adrenal: early as the fourth week. Anterior surface : Differentiation of cortical zones begins in the eighth Superior: peritoneum (posterior wall of the week. omental bursa) and the stomach. These zones may be distinguished at birth although they Inferior : Body of the pancreas do not appear in the final adult form until the fourth year Posterior surface: of postnatal life Medial: left crus of the diaphragm Lateral: medial aspect of the left kidney Surgical Anatomy The adult adrenal gland weighs 4 to 8 g and measures 4 x Vascular Supply 3 x 1 cm. Arterial Supply : It is larger in women than in men. The adrenal glands and the thyroid gland are the viscera The adrenal glands are composed of two distinct parts, having the greatest blood supply per gram of tissue. with differing functions and embryonic origins. As many as 60 arterial twigs may enter the adrenal The volume of the larger portion, the cortex, is 8 to 20 gland. times that of the medulla. The arterial supply of the adrenal glands arises, in most The adrenal glands lie on the anteromedial surface of the cases, from three sources 1)Superior adrenal arteries kidneys near the superior poles; both the glands and the 2)Middle adrenal artery 3) Inferior Adrenal artery kidneys are retroperitoneal. All these arteries branch freely before entering the The two glands differ in shape. adrenal gland, so 50-60 arteries penetrate the capsule The left is more flattened and has more extensive contact over the entire surface. with the kidney. It is crescentic or semilunar in form, and may extend on Venous Drainage the medial surface of the kidney almost to the hilum The adrenal venous drainage does not accompany the The right gland is more triangular or pyramidal and lies arterial supply, and is much simpler. higher on the kidney. A single vein drains the adrenal gland, emerging at the Each adrenal gland, together with the associated kidney, hilum. is enclosed in the renal fascia (of Gerota) The left vein passes downward over the anterior surface It is surrounded by fat, although the adrenal gland is of the gland. This vein is joined by the left inferior phrenic separated from the kidney by a partition of connective vein before entering the left renal vein. tissue. The right vein is typically very short; it may be 0.5 cm The perirenal fat is more yellow and of a firmer long, or even less. consistency than fat elsewhere in the abdomen. The right adrenal vein passes obliquely to open into the The adrenal glands are firmly attached to the fascia, posterior side of the inferior vena cava. which is in turn firmly attached to the abdominal wall and The right adrenal vein does not usually have any to the diaphragm. tributaries other than from the adrenal gland. The inferior phrenic arteries pass superior to the adrenals The right adrenal vein may drain into the right hepatic to reach the diaphragm. vein, close to the junction of the hepatic vein with the The inferior phrenic arteries give off a series of branches, inferior vena cava. the superior adrenal arteries, like teeth of a comb. A layer of loose connective tissue separates the capsule of the adrenal gland from that of the kidney Lymphatic Drainage Adrenelectomy The lymphatics of the adrenal gland are usually said to Indications for Adrenelectomy : consist of a profuse subcapsular plexus that drains with Unilateral the arteries and a medullary plexus that drains with the 1) Aldosteronoma adrenal veins. 2) Cortisol secreting Adenoma (Cushing syndrome) Drainage is to renal hilar nodes, lateral aortic nodes, and 3) Unilateral pheochromocytoma to nodes of the posterior mediastinum above the 4) Virilizing or feminizing tumours diaphragm by way of the diaphragmatic orifices for the 5) Non functioning unilateral tumors (Size >4-5 cm) splanchnic nerves. 6) Adrenalcortical carcinomas The majority of capsular lymphatic vessels pass directly to 7) Solitary unilateral metastasis. the thoracic duct without the intervention of lymph nodes. Bilateral 1)Bilateral pheochromocytoma. Innervation 2) Cushing syndrome due to B/L nodular adrenal hyperplasia. The adrenal cortex appears to have only vasomotor 3) Cushings disease (pituitary tumour) unsuccessfully treated innervation. by surgery or radiation. Most of the fibers reaching the gland from the splanchnic nerves, the lumbar sympathetic chain, the celiac Anterior Approach for Right Adrenalectomy ganglion, and the celiac plexus enter the medulla. On the right, the anterior approach to the adrenal gland These fibers are preganglionic and end on the medullary begins with the mobilization of the hepatic flexure of the chromaffin cells. colon. Mobilization of the colon will expose the duodenum. The Histology second portion of the duodenum is freed by incision of its Adrenal Cortex : lateral avascular peritoneal reflection. The vascularity of the adrenal cortex is among the It can now be separated from retroperitoneal structures greatest in the entire body. and reflected forward and to the left (Kocher maneuver). The adrenal cortex is composed of three zones: the zona glomerulosa, the zona fasciculata, and the zona reticularis. In all three zones, all cells produce steroids. In the zona glomerulosa (the outermost layer), small cells are arranged in roughly spherical groups. This zone secretes the mineralocorticoid aldosterone. In the zona fasciculata, larger cells are arranged in columns which are oriented radially. Posterior Approach The carbohydrate-active steroid, cortisol, and the adrenal sex steroids are produced here. Vitamin C is abundant in these cells. In the third layer, the zona reticularis, small cells are arranged in strands forming an irregular network. These cells secrete cortisol, androgens, and estrogens. Cholesterol is present as a precursor to the genesis of the steroids. Thoracoabdominal Approach Adrenal Medulla The cells in the adrenal medulla are large and pale. They secrete epinephrine and have a chromaffin reaction. These cells are called chromaffin cells, pheochromocytes. Distributed throughout the medulla, but few in number, are postganglionic sympathetic neurons. Most medullary cells secrete epinephrine, but some secrete norepinephrine instead.