52.

Cefalosporinele
Generatia I Preparate Cale de amd. Spectrul
antimicrobian
Generatia I Cefazolina oral Stafilococ
Cefalexina parenteral Streptococ
Cefaloxina i/m Pneumococ
Clostridium
Klebsiela
Generatia II Cefaclor Klebsiela
Ceforamid oral Salmonela
Ceforixin Shigella
Cefuroxim parenteral i/m Iersinia
Clostridium
Generatia III Cefixim Oral Streptococi
Cefatoxim parenteral i/m A,B,C,G
Ceftriaxon Pneumococi
Generatia IV Cefeprim parenteral Gram+
Cefpirom Gram-
M.aerobi,anaerobi

Indicatii terapeutice pentru cefalosporine

Generatia Indicatii terapeutice Nota
Generatia I Infectii al cailor respiratorii,urogenitale,al Cefalosporine
pielii oaselor si articulatiilor. Sunt toxice
Profilaxia complicatiilor postoperatorii.
Generatia II Pneumonii,sepsis,infectii al bazinului mic si Intoleranta cu
intraabdominal,gonoree,meningite,complicatii alcool
postoperatorii
Generatia Infectii septice grave al organelor pelviene
III,IV infectii anaerobe
gangrene gazoasa
Reactii adverse:Toxicitate redusa dar pot produce reactive de hipersensibilitate la
preparat,soc anafilactic,bronchospasm,urticarie.