PHARMACEUTICAL TECHNOLOGY

1. The ability of a substance dissolves in 5. Which of the following co solvents

a given solvent system is depends on are used to increase the solubility of a
(a) Nature and intensity of the forces drug
present in the solute (a) Ethanol
(b) Nature and intensity of the forces (b) Sorbitol
present in the solvent (c) Glycerin
(c) Interactions between solute and (d) All the above
solvent
(d) All the above 6. Which of the following co solvent is
accepted as a co solvent in parenteral
2. Which of the following substances
products, but its use in oral liquids is
having poor water solubility
limited
(a) Weak electrolytes
(b) Non-polar molecules (a) Glycerol formal
(c) Both (b) Glycerol
(d) None (c) Dimethyl acetamide
3. The solubility of weak electrolytes & (d) None
non-polar substances can be increased
by adding water miscible solvents. 7. Due to which factor, dimethyl aceta-
This process is known as mide is not been used as a co-solvent
(a) Co-solvency in oral liquids
(b) Complexation (a) Due to objectionable odor
(c) Both (b) Due to objectionable taste
(d) None
(c) Both
4. How co-solvents increase the solubility (d) None
of poorly soluble drugs?
(a) By reducing the interfacial 8. Thiomersal is belongs to which
tension between the predominant category preservative
aqueous solution and hydro- (a) Acidic
phobic solute
(b) Neutral
(b) By reducing the interfacial
tension between solute and (c) Mercurial
solvent (d) Quaternary ammonium
(c) Both compounds
(d) None

1
2 MCQs in Pharmaceutical Sciences

9. Which of the following are widely 16. Most widely used flavoring agent in
used and excellent preservatives food industry
(a) Mercurial (a) Menthol
(b) Quaternary ammonium compounds (b) Chloroform
(c) Both (c) Mono sodium glutamate
(d) Acidic (d) None
10. Benzalkonium chloride is categorized 17. Which of the following flavor is not
as responsible for sour taste
(a) Acidic preservative (a) Citrus flavors (b) Liquorice
(b) Neutral preservative (c) Raspberry (d) Mint spice
(c) Mercurial preservative
(d) Quaternary ammonium 18. The filling method of a pharmaceutical
compounds liquid depends on the following factors
(a) Viscosity of the liquid
11. At which concentration, phenol act as
(b) Surface tension of the liquid
preservative
(a) 0.2 0.5 (b) 0.5 0.8 (c) Compatibility with the materials
used in the construction of the
(c) 0.05 0.1 (d) None
filling machine
12. Which of the following sugar has bitter (d) All the above
taste
(a) Glucose (b) Sucrose 19. Which of the following methods are
generally used in liquid filling
(c) Saccharine (d) None
(a) Gravimetric
13. Which of the following is a synthetic (b) Volumetric
sweetener (c) Constant level method
(a) Glucose (b) Sucrose (d) All the above
(c) Sorbitol (d) Aspartame
20. In the formulation of suspensions,
14. To increase the viscosity of liquid, which generally which types of drugs are
of the following agents are used selected?
(a) PVP (a) Hydrophilic (b) Hydrophobic
(b) Methyl Cellulose (c) Both (d) None
(c) Sodium Carboxy Methyl
Cellulose 21. In the formulation, to facilitate the
wetting of insoluble solids, which of
(d) All the above
the following agents used
15. Which of the following agents are used (a) Suspending agents
as flavoring agents (b) Flavoring agents
(a) Menthol (b) Chloroform (c) Wetting agents
(c) Both (d) None (d) None
 Pharmaceutical Technology 3

22. How surfactants will facilitate or aid 26. The temperature at which the inversion
wetting of hydrophobic materials in occurs depends on emulsifier concen-
liquid tration is known as
(a) By decreasing the solid-liquid (a) Phage temperature
interfacial tension (b) Inversion temperature
(b) By increasing the solid-liquid (c) Phase inversion temperature
interfacial tension (d) All
(c) Both
(d) None 27. Which of the following mechanical
equipment can be used for emulsifi-
23. Stokes equation is expressed as cation?
2r 2 (d1 d 2 )g (a) Homogenizers
(a) V = (b) Mechanical stirrers
9
(c) Ultra sonifiers
2r 2 (d1 d 2 )g (d) All
(b) V =
18
28. Which of the following is not used as a
(c) Both
emulsifying agent?
(d) None
(a) Surfactant
24. The stability of suspensions can be (b) Hydrophilic colloids
evaluated by (c) Electrolytes
(a) Sedimentation volume (d) Finely divided solids
(b) Degree of flocculation
29. HLB system was developed by
(c) Re-dispersibility
(d) All (a) Griffin (b) Stocks
(c) Dalla Valle (d) None
25. To identify the emulsion type, which of
the following tests are conducted? 30. Gum Arabic is a
(a) Dilution test (a) Anionic polysaccharide
(b) Dye test (b) Cationic polysaccharide
(c) Conductivity test (c) Neutral polysaccharide
(d) All (d) None

KEY
1. (a) 2. (c) 3. (a) 4. (a) 5. (d)
6. (c) 7. (c) 8. (c) 9. (c) 10. (d)
11. (a) 12. (c) 13. (d) 14. (d) 15. (c)
16. (c) 17. (d) 18. (d) 19. (d) 20. (b)
21. (c) 22. (a) 23. (b) 24. (d) 25. (d)
26. (c) 27. (d) 28. (c) 29. (a) 30. (c)
4 MCQs in Pharmaceutical Sciences

1. Which of the following is not a 8. Promulgen means

semisolid dosage form (a) Anionic emulsifiers composed of
(a) Paste (b) Creams fatty alcohols & their ethoxylates
(c) Ointments (d) Suspensions (b) Non-ionic emulsifiers com-posed
of fatty alcohols & their
2. Generally pastes contain ethoxylates
(a) High percentage of insoluble (c) Cationic emulsifiers composed of
solids fatty alcohols & their ethoxylates
(b) Low percentage of insoluble (d) All the above
solids
9. Promulgen D contains
(c) Both
(a) Cetyl alcohol & Ceteareth-20
(d) None
(b) Stearyl alcohol & Ceteareth-20
3. Most widely used hydrocarbon in (c) Both
semi-solid dosage forms (d) None
(a) Petrolatum (b) Mineral oil 10. Promulgen G contains
(c) Both (d) None (a) Cetyl alcohol & Ceteareth-20
4. Which of the following hydrocarbon (b) Stearyl alcohol & Ceteareth-20
waxes are employed in the manufacture (c) Both
of creams and ointments? (d) None
(a) Paraffin wax (b) Ceresin 11. With promulgen D, which type of
(c) Both (d) None emulsion generally obtained?
(a) Liquid emulsion
5. Which of the following is not a
(b) Thick consistency emulsion
vegetable oil
(c) Both
(a) Peanut oil (b) Almond oil
(d) None
(c) Olive oil (d) Petrolatum
12. With promulgen G, which type of
6. Which of the following fatty acid used in emulsion generally obtained?
water removable creams as emulsifier (a) Liquid emulsion
(a) Stearic acid (b) Palmitic acid (b) Thick consistency emulsion
(c) Both (d) None (c) Both
(d) None
7. Combination of a surfactant with oil-
soluble auxiliary emulsifier is known 13. Which of the following polyols used as
as humectants in creams
(a) Simple emulsifier system (a) Glycerine
(b) Mixed emulsifier system (b) Propylene glycol
(c) Both (c) Sorbitol 70%
(d) None (d) All the above

14. The choice of humectants is based on
(a) Rate of moisture exchange
(b) Viscosity and texture of
preparation
(c) Both
(d) None
15. Which of the following is more
hygroscopic at low concentration?
(a) Sorbitol 70% (b) Glycerine
(c) Both (d) None
16. Due to which factors, petrolatum is
most widely used as a hydrocarbon
basic in ointments
(a) Its consistency
(b) Its neutral characteristics
(c) Its ability to spread easily on the
skin
(d) All
17. Water number means
(a) Maximum amount of water that
can be added to 100 g of a base at
given temperature
(b) Maximum amount of water that
can be added to 10 g of a base at
given temperature
(c) Maximum amount of water that
can be added to 5 g of a base at
given temperature
(d) All
18. Lanolin is which type of base
(a) Hydrocarbon base
(b) Absorption base
(c) Both
(d) None
Pharmaceutical Technology 5
19. In the preparation of vanishing creams,
which types of bases are used
generally?
(a) Absorption bases
(b) Water removable bases
(c) Hydrocarbon bases
(d) None
20. In the preparation of cold creams,
which types of bases are used
generally?
(a) Absorption bases
(b) Water removable bases
(c) Hydrocarbon bases
(d) None
21. Water soluble bases are also known as
(a) Greasy ointment bases
(b) Greaseless ointment bases
(c) Both
(d) None
22. In pastes, the concentration of
insoluble powder substances in
(a) 20%-50%
(b) 50%-100%
(c) 50%-75%
(d) None
23. Jellies are generally
(a) Water-soluble bases
(b) Water-insoluble bases
(c) Both
(d) None
24. As per USP XX, the term object-
ionable means
(a) An organism can cause disease or
the presence may interrupt the
function of the drug or lead to
deterioration of the product
6 MCQs in Pharmaceutical Sciences

(b) Pathogens if they produce 25. The success or failure of a preservative

disease or infection, in the
newborn or debilitated persons
(c) Organisms or their toxins that are
responsible for human disease or
infection
(d) None
in protecting a formulation against
microbial spoilage depends on
(a) Interaction between preservative
with surfactant
(b) Interaction between preservative
with active substances
(c) Sorption by packaging materials
(d) All the above

KEY
1. (d) 2. (a) 3. (c) 4. (c) 5. (d)
6. (a) 7. (b) 8. (b) 9. (a) 10. (b)
11. (b) 12. (a) 13. (d) 14. (c) 15. (a)
16. (d) 17. (a) 18. (c) 19. (b) 20. (a)
21. (b) 22. (a) 23. (a) 24. (a) 25. (d)
 Pharmaceutical Technology 7

1. A suppository is generally intended for 9. Shape of vaginal suppositories is

use in (a) Oviform shape
(a) Rectum (b) Torpedo shape
(b) Vagina (c) Pencil shape
(c) Urethra (d) None
(d) All the above
10. Rectal suppositories mainly used for
2. Vaginal suppositories also called as the treatment of
(a) Pessaries (a) Constipation (b) Hemorrhoids
(b) Simple suppositories (c) Both (d) None
(c) Bougies
11. The number of milligrams of KOH
(d) None
required neutralizing free acids &
3. Oleum theobromae was first recom- saponify the esters contained in 1 g of
mended by fat is known as
(a) A.B. Taylor (b) Griffin (a) Iodine value
(c) Stockss (d) None (b) Saponification value
(c) Water number
4. Weight of rectal suppository for adults (d) Acid value
is
(a) 1 g (b) 2 g 12. The number of grams of iodine that
(c) 5 g (d) None reacts with 100 g of fat is known as
(a) Iodine value
5. Weight of rectal suppository for
(b) Saponification value
children is
(c) Water number
(a) 1 g (b) 2 g
(d) Acid value
(c) 5 g (d) None
13. The number of milligrams of KOH
6. Urethral suppositories also called as
required neutralizing free acids in 1 g
(a) Pessaries (b) Bougies
of fat is known as
(c) Both (d) None
( a) Iodine value
7. Urethral suppositories having which (b) Saponification value
shape (c) Hydroxil value
(a) Oviform shape (d) Acid value
(b) Torpedo shape
(c) Pencil shape 14. The number of milligrams of KOH
required neutralize the acetic acid used
(d) None
to acetylate 1 g of fat is known as
8. Weight of urethral suppository for (a) Iodine value
males & females respectively (b) Saponification value
(a) 4 & 2 (b) 2 & 4 (c) Hydroxil value
(c) 4 & 6 (d) 6 & 4 (d) Acid value
8 MCQs in Pharmaceutical Sciences

15. Which of the following method is used (b) Compression molding

to manufacture suppositories (c) Pour molding
(a) Hand molding (d) All the above
(b) Compression molding
21. Which formula can be used to
(c) Pour molding
calculate the amount of base that is
(d) All the above
replaced by active ingredients?
16. Which of the following is most 100 (G E)
commonly used suppository base (a) f = +1
(G) (X)
(a) Cocoa butter
(b) PEG 1000 100 (E G)
(b) f = +100
(c) PEG + Hexanetriol (G) (X)
(d) None 100 (E G)
(c) f = +1
17. Cocoa butter available in following (G) (X)
forms 100 (E G)
(a) -form (b) -form (d) f = +10
(G) (X)
(c) -form (d) All
22. Rancidity generally results from
18. The solidification point of cocoa butter (a) Auto oxidation
lies between (b) Decomposition of unsaturated
(a) 12 13o (b) 20 30o fats
(c) 5 10o (d) None (c) Both
19. Which of the following method is (d) None
simple & oldest method of preparation 23. Which of the following is not antioxi-
of suppositories? dant
(a) Hand molding (a) BHT (b) BHA
(b) Compression molding (c) Tocopherol (d) Theobroma oil
(c) Pour molding
24. Suppositories are generally evaluated
(d) All the above
by
20. Most commonly used method for (a) Melting range test
producing suppositories on both a (b) Breaking test
small & large scale is (c) Liquefaction
(a) Hand molding (d) All the above
KEY
1. (d) 2. (a) 3. (a) 4. (b) 5. (a)
6. (b) 7. (c) 8. (a) 9. (a) 10. (c)
11. (b) 12. (a) 13. (d) 14. (c) 15. (d)
16. (a) 17. (d) 18. (a) 19. (a) 20. (c)
21. (c) 22. (c) 23. (d) 24. (d)
 Pharmaceutical Technology 9

1. Which of the following materials are 8. To produce molten glass, which of the
used in pharmaceutical packaging? following method is used
(a) Glass (a) Blowing (b) Drawing
(b) Plastic (c) Pressing (d) Casting
(c) Metal
(d) All the above 9. To protect the contents of a bottle from
the effects of sunlight by UV rays,
2. Which of the following packaging which glass is used?
material is protect the drug content (a) Amber glass (b) Red glass
against light
(c) Both (d) None
(a) Plastic containers
(b) Amber colored glass containers 10. To evaluate the chemical resistance of
(c) Both glass, which of the following tests are
(d) None conducted?
3. Major disadvantages of glass as a (a) Powder glass
packing material are (b) Water attack test
(a) Fragility (b) Weight (c) Both
(c) Both (d) None (d) None

4. Composition of glass is 11. Which of the following test is

(a) Sand performed on crushed grains, to
(b) Soda ash evaluate the chemical resistance of
(c) Lime stone & Cullet glass?
(d) All the above (a) Powder glass
(b) Water attack test
5. Soda ash also known as
(c) Both
(a) Pure silica
(d) None
(b) Sodium carbonate
(c) Lime stone 12. Which of the following test is
(d) Calcium carbonate performed on whole container?
6. Which of the following one is a broken (a) Powder glass
glass & acts as fusion agent (b) Water attack test
(a) Cullet (b) Soda ash (c) Both
(c) Lime stone (d) Sand (d) None
7. Which of the following methods are 13. Type I glass is also known as
used in the production of glass (a) Borosilicate glass
(a) Blowing (b) Regular soda-lime glass
(b) Drawing (c) Treated soda-lime glass
(c) Pressing & casting (d) None
(d) All the above
10 MCQs in Pharmaceutical Sciences

14. The advantages of plastic containers (c) Bubble pack

over glass containers are (d) All the above
(a) Easy formation
(b) Resistance to breakage 18. Which of the following packaging is
(c) Freedom of design commonly used for packaging of
tablets & capsules?
(d) All the above
(a) Blister pack (b) Strip pack
15. Plastic containers are generally made (c) Both (d) None
from the following material
(a) Polyethylene 19. Which of the following materials offer
moisture barrier properties?
(b) Polypropylene
(a) Aclar
(c) Polystyrene
(b) Cellophane
(d) All the above
(c) Polyester
16. Which of the following ingredients are (d) All the above
present in rubber stopper?
(a) Vulcanizing agent 20. Which of the following mechanism is
responsible for release of encapsulated
(b) Softner
core materials?
(c) Antioxidant
(a) By disrupting the coating by
(d) All the above
pressure
17. Which of the following packaging (b) By offering permeability
systems are identified by the FDA? facilities
(a) Blister pack (c) By leaching of permanent fluid
(b) Strip pack (d) All the above

KEY

1. (d) 2. (b) 3. (c) 4. (d) 5. (b)

6. (a) 7. (d) 8. (a) 9. (c) 10. (c)
11. (a) 12. (b) 13. (a) 14. (d) 15. (d)
16. (d) 17. (d) 18. (b) 19. (d) 20. (d)
 Pharmaceutical Technology 11

1. Pre - formulation studies mainly focus 6. Which of the following techniques

on used to prepare amorphous forms?
(a) Physical properties of new (a) Rapid precipitation
compound (b) Lyophilization
(b) Chemical properties of new (c) Rapid cooling
compound (d) All the above
(c) Physico-chemical properties of
new compound 7. Amorphous forms generally having
(d) None (a) Low thermodynamic energy &
low solubility
2. Which of the following information is (b) High thermodynamic energy &
helpful in designing the pre- high solubility
formulation evaluation of a new drug? (c) Both
(a) Structure of a compound (d) None
(b) Formula & molecular weight of a
compound 8. Which of the following compound
(c) Therapeutic indication of a new possess high aqueous solubilitys?
compound (a) Hydrates (b) Anhydrates
(d) All the above (c) Both (d) None

3. Which of the following problems 9. Which of the following properties may

commonly encountered in evaluating change with changing of the internal
salt forms are structure of a solid?
(a) Poor crystallinity (a) Melting point
(b) Hygroscopicity (b) Density
(c) Instability (c) Optical properties
(d) All the above (d) All the above

4. Which of the following salts generally 10. Which of the following methods
used in pharmaceutical products? generally used for studying solid
(a) Acetate forms?
(b) Gluconate (a) DSC
(c) Lactate (b) XRD
(d) All the above (c) TGA
(d) All the above
5. Description of the outer appearance of
a crystal is known as 11. Which of the following methods
(a) Crystal habit generally used to measure heat loss or
(b) Internal structure gain within a sample?
(c) Both (a) DSC (b) DTA
(d) None (c) Both (d) None
12 MCQs in Pharmaceutical Sciences

12. Which of the following co-solvent can 14. Dissolution of a drug particle is
be used to increase the solubility of described by
poor soluble drugs? (a) Noyes-Whitney equation
(a) Ethanol (b) Stocks equation
(b) Propylene glycol (c) Drags equation
(c) Glycerin (d) None
(d) All the above
15. The effect of temperature on drug
13. Partition co-efficient generally stability can be described by
measures (a) Noyes-Whitney equation
(a) Drugs lipophilicity (b) Stocks equation
(b) Ability of drug to cross cell (c) Arheneous equation
membrane (d) None
(c) Both
(d) None

KEY

1. (c) 2. (d) 3. (d) 4. (d) 5. (a)

6. (d) 7. (b) 8. (b) 9. (d) 10. (d)
11. (c) 12. (d) 13. (c) 14. (a) 15. (d)
 Pharmaceutical Technology 13

1. Unequal distribution of color on a 5. If the dose of a drug is inadequate, then

tablet, refers to it generally requires the following one,
(a) Picking (b) Mottling to make up its bulk
(c) Capping (d) Sticking (a) Binders
2. Match the following and find out the (b) Disintegrants
correct combination (c) Lubricants
1. Capping (d) Diluents
(P) Separation of a tablet into 2 or
6. The first and most widely used diluent
more layers
in tablet formulation is
2. Lamination
(a) Dextrose (b) Lactose
(Q) Unequal distribution of color
on a tablet (c) MCC (d) Starch
3. Mottling
7. Anhydrous lactose has the advantage
(R) Separation of top/bottom over hydrous lactose
crowns of a tablet from the
(a) Improved flow
main body
4. Sticking (b) Absence of millard reaction
(S) Adherence of tablet material (c) Improved compressibility
to the die wall (d) High microbial load
(a) 2-P, 3-Q, 1-R, 4-S
8. Which of the following is not a
(b) 1-P, 2-Q, 3-R, 4-S
commercially available starch product?
(c) 3-P, 1-Q, 2-R, 4-S
(a) Sta-Rx 1500 (b) Celutab
(d) 4-P, 1-Q, 3-R, 2-S
(c) Emdex (d) Sugar tab
3. Which of the following one is
responsible for sticking? 9. Which of the following is a synthetic
(a) Excessive moisture adhesive?
(b) Low moisture (a) PVP (b) MC
(c) Both (c) HPMC (d) HPC
(d) None
10. Which of the following is a water
4. Which of the following mixer is a first soluble lubricant?
high shear powder blender/mixer (a) Stearic acid
(a) Diosna mixer (b) Mineral oil
(b) Littleford lodige mixer (c) PEG
(c) Plow mixer (d) Magnesium stearate
(d) Gral mixer
14 MCQs in Pharmaceutical Sciences

11. Find out the correct statements 2. Diluent

regarding a sweetener, saccharin (Q) Pyramine
(P) It is 500 times sweeter than 3. Adherent
sucrose, but it is carcinogenic (R) Colloidal silica
(Q) It is 500 times sweeter than 4. Disintegrant
sucrose, but it has bitter taste (S) Calcium sulphate
(R) It is sweeter than sucrose, but it (T) Sodium alginate
is safe (a) 1-R, 2-S, 3-P, 4-T
(S) It is sweeter than sucrose, but it (b) 1-S, 2-R, 3-Q, 4-P
is unstable (c) 1-R, 2-S, 3-T, 4-Q
(a) P, S (b) P, R (d) 1-Q, 2-T, 3-R, 4-P
(c) P, Q (d) R, S
17. Enteric coating is achieved by using
12. Aerosil is used as
(a) HPMC (b) CMC
(a) Glidant (b) Lubricant
(c) CAP (d) Povidine
(c) Antiadherant (d) None
18. The disintegration time for sugar
13. What is the pH of duodenum? coated tablets is
(a) 2-3 (b) 7-8 (a) 30 minutes (b) 45 minutes
(c) 4-6 (d) 10 (c) 60 minutes (d) 75 minutes
14. Tablets, which are placed between 19. Flow rate of granules from the hopper
cheek and teeth, are known as can be improved by adding
(a) Buccal (b) Sublingual (a) Disintegrant (b) Glidant
(c) Lozenges (d) Troches (c) Binder (d) Lubricant
15. Which statement is not correct?
20. Given below are equipment used in the
(a) Buccal routes avoids first pass manufacture of following products P-
metabolism T. Match them and find out correct
( b) Parenteral route avoids first pass answer
metabolism
1. Zenasi
(c) Sublingual route avoids first pass
metabolism (P) Tablet granules
(d) Oral route avoids first pass 2. Hepa filter
metabolism (Q) Tablet coating
16. Match the following ingredients 3. Chilsonator
according to their purpose in the (R) Emulsion
formulation of tablets and find out the 4. Accela cota
correct set
(S) Injectables
1. Glidant
(P) Pre- gelatinized starch (T) Capsule
 Pharmaceutical Technology 15

(a) 1-T, 2-S, 3-P, 4-Q 23. In sugar coating of tablets, sub- coating
(b) 1-P, 2-Q, 3-S, 4-R is done
(c) 1-T, 2-R, 3-Q, 4-P (a) To prevent moisture absorption
(d) 1-S, 2-R, 3-P, 4-Q (b) To round the edge & build tablet
size
21. Match the ingredients according to (c) To smoothen the surface
their purpose in the formulation and (d) To prevent the tablet from
find out correct set breaking due to vibration
1. Film coating
(P) Sodium benzoate 24. Some possible causes are mentioned in
P-T, for the following defects during
2. Syrups the film coating of tablets. Match them
(Q) Ethyl cellulose 1. Chipping
3. Emulsification (P) Poor spreading during
(R) Eudragit spraying
4. Enteric coating 2. Cracking
(Q) Over heating during
(S) Sucrose
spraying
(T) Sodium oleate 3. Orange peel
(a) 1-P, 2-Q, 3-R, 4-S (R) Higher internal stresses in
(b) 1-R, 2-S, 3-T, 4-Q film
(c) 1-T, 2-P, 3-S, 4-Q 4. Blistering
(d) 1-R, 2-S, 3-Q, 4-T (S) Excessive coating process
22. Match the following regions in GIT (T) Precipitation of polymer due
with the pH levels indicated from P-T to high temperature/poor
and find out correct answer solvent
1. Mouth (a) 1-S, 2-R, 3-P, 4-Q
(P) 5-6 (b) 1-T, 2-S, 3-R, 4-P
2. Stomach (c) 1-P, 2-Q, 3-R, 4-S
(Q) 6.8-7.5 (d) 1-R, 2-P, 3-Q, 4-T
3. Deodenum 25. Sub coating is given to the tablets
(R) 6.8-7 (a) To increase the bulkiness
4. Large intestine (b) To avoid deterioration due to
(S) 3-5 microbial attack
(T) 1.5-3 (c) To prevent the solubility in acidic
(a) 1-Q, 2-T, 3-S, 4-R medium
(b) 1-P, 2-R, 3-S, 4-T (d) To avoid stickness
(c) 1-S, 2-T, 3-Q, 4-R
(d) 1-R, 2-S, 3-T, 4-P
16 MCQs in Pharmaceutical Sciences

26. The following ingredients are 30. Tablets are placed into coating
commonly used as coating agents for chamber & hot air is introduced
film coating except through the bottom of the chamber.
(a) CAP Coating solution is applied through an
(b) Carnauba wax atomizing nozzle from the upper end
(c) HEC of the chamber. This technique is
(d) Sodium CMC called
(a) Sealing before sugar coating
27. The ingredients mentioned in P-S are
used in various stages of sugar coating (b) Coating by air suspension
of tablets. Match them and find out (c) Spray-pan coating
correct answer (d) Chamber coating
1. Seal coating
(P) Gelatin 31. A synthetic sweetening agent which is
2. Sub coating approximately 200 times sweeter than
(Q) Carnauba wax sucrose & has no taste is
3. Syrup coating (a) Saccharin (b) Aspartame
(R) PEG 4000 (c) Cyclamate (d) Sorbitol
4. Polyshing
32. Shellac is used the purpose of coating
(S) Cane sugar
tablets as
(a) 1-S, 2-P, 3-R, 4-Q
(a) Polishing agent
(b) 1-Q, 2-S, 3-R, 4-P
(c) 1-P, 2-Q, 3-R, 4-S (b) Film coating agent
(d) 1-R, 2-P, 3-Q, 4-S (c) Enteric coating agent
(d) Sub-coating agent for sugar
28. The courster process can be used to coating
(a) Coat tablets
(b) Determine the disintegration time 33. Dose dumping is a problem in the
(c) Gas sterilize parenteral solution formulation of
(d) Automatic filling of capsules (a) Compressed tab
(b) Suppository
29. Which of the following is the first (c) Soft gelatin capsules
process that must occur before a drug
(d) Controlled release drug products
can become available for absorption
from a tablet dosage form? 34. Select the equation that gives the rate
(a) Dissolution of the drug in GI of drug dissolution from a tablet
fluids
(a) Ficks law
(b) Dissolution of the drug in
(b) Henderson-Hasselbatch equation
epithelium
(c) Ionization of the drug (c) Noyes-Whitney equation
(d) Disintegration of the drug (d) Michelis Menton equation
 Pharmaceutical Technology 17

35. Which of the following substance is 41. A retardant material that forms a
used as muco adhesive hydrophilic matrix in the formulation
(a) Acacia of matrix tablets is
(b) Sodium CMC (a) HPMC
(c) Burnt sugar (b) CAP
(d) Saccharin (c) Polyethylene
(d) Carnauba wax
36. In the preparation of multi layer
tablets, one of the following is used for 42. A water soluble substance used as
hydrophilic matrix coating coating material in micro
(a) Shellac encapsulation process is
(b) CMC (a) Polyethylene (b) Silicone
(c) Stearyl alcohol (c) HEC (d) Paraffin
(d) Bees wax
43. One of the following is used as a pH
37. The diameter of the mesh aperture in dependant controlled release excipient
the I.P. disintegration apparatus is (a) Carnauba wax
given below. Choose the correct size (b) HPMCP
(a) 2 mm (b) 4 mm (c) MC
(c) 1mm (d) 1.50 mm (d) Glyceryl mono stearate

38. Diclofenac tablet with CAP has been 44. In the tablet coating process,
administered to a patient. Where do inadequate spreading of coating
you expect the drug to be released? solution before drying causes
(a) Stomach (b) Oral cavity (a) Orange peel effect
(c) Small intestine (d) Liver (b) Sticking effect
(c) Blistering effect
39. Which of the following flavor is used (d) Picking effect
in a formulation containing sour taste?
(a) Wild cherry (b) Vanilla 45. Crown thickness of a tablet is
(c) Citrus (d) Chocolate measured by
(a) Micrometer
40. Durability of a tablet to combined (b) Pychnometer
effects of shock & abrasion is (c) Hydrometer
evaluated by using (d) All the above
(a) Hardness tester
(b) Disintegration test apparatus 46. Friabilator is operated at
(c) Friabilator (a) 100 RPM (b) 75 RPM
(d) Screw guage (c) 50 RPM (d) 25 RPM
18 MCQs in Pharmaceutical Sciences

47. Enteric coated tablet disintegrate in (c) 2% w/v of methyl cellulose

hours in simulated intestinal fluid dispersion
(a) 1 (b) 2 (d) None
(c) 3 (d) 4
56. Lozenges were originally named as
48. In dissolution test, flask is maintained (a) Capsule
at (b) ODT
(a) 37oC 0.5oC (b) 41oC 1oC (c) Pastillies
(c) 39oC 0.6oC (d) 40oC 1oC (d) Sustained axn tab
49. Capping is prevented by using one of
57. Implantation tab are NMT..mm in
the following punches
length
(a) Flat (b) Circular
(a) 20 (b) 100
(c) Square (d) Rectangular
(c) 40 (d) 8
50. Plating of punch faces are done by
(a) Chromium (b) Zinc 58. Seal coating is done by using
(c) Iron (d) All (a) Shellac (b) Acacia
(c) Gelatin (d) None
51. Sta-Rx-1500 contains % of
moisture 59. Sub coating is done to
(a) 15 (b) 10 (a) Round the edges
(c) 18 (d) 50 (b) Increase the bulk of tablet
(c) Both a & b
52. Acacia trgacanth is used in the
concentration of (d) Make water resistant
(a) 10%-25 % (b) 60%-70 % 60. CAP dissolves at PH
(c) 40%-50 % (d) 90% (a) Above 6 (b) Below 6
53. Starch on heating hydrolyze into (c) 4 (d) 2
(a) Glucose
61. Which of the following one is used as
(b) Fructose & Sorbose opacifier
(c) Fructose & Mannose (a) TiO2
(d) Dextrin & Glucose
(b) Mgo
54. PH of the small intestine is (c) Siliactes
(a) 1-2 (b) 3-4 (d) All of the above
(c) 6 (d) 7-8
62. Green bone is a source of
55. Aqua coat is a (a) Type A Gelatin
(a) 30% w/v of ethyl cellulose (b) Type B Gelatin
dispersion (c) Both
(b) Solution of HPMC (d) None
 Pharmaceutical Technology 19

63. Empty capsule has moisture content in 68. Foam stability is measured by
the range of (a) IR Spectroscopy
(a) 60% (b) 12%-15 % (b) UV Spectroscopy
(c) 50%- 70% (d) 30% (c) Rotational viscometers
(d) All
64. Which treatment is used for solubility
of gelatin 69. Particle size is determined by
(a) Heat (b) Formalin (a) Gas Chromatography
(c) Water (d) Alcohol (b) Cascade impactor
(c) Light scatter decay
65. Which of the following is used to fill (d) Both b & c
powdered dry solid into soft gelatin
capsule 70. Chewable tablet contains the following
(a) Aceo gel (b) Rotobil base
(c) Rotosort (d) Rotoweigh (a) Manitol (b) Glucose
(c) Lactose (d) None
66. Sealing of capsule is achieved by
(a) 100oC (b) 20oC 71. Which of the following is not added in
(c) 37oC-40oC (d) 70oC lozenges?
(a) Sweetener (b) Binder
67. Moisture content is determined by (c) Disintegrant (d) All
(a) Gas Chromatography
(b) K-F Method 72. Enteric coated tablet is disintegrated in
(c) Both (a) Stomach (b) Liver
(d) None (c) Intestine (d) Mouth

KEY

1. (b) 2. (c) 3. (a) 4. (b) 5. (d)

6. (b) 7. (b) 8. (d) 9. (a) 10. (c)
11. (c) 12. (a) 13. (c) 14. (a) 15. (d)
16. (a) 17. (c) 18. (c) 19. (b) 20. (a)
21. (b) 22. (a) 23. (b) 24. (a) 25. (d)
26. (b) 27. (a) 28. (a) 29. (d) 30. (b)
31. (b) 32. (c) 33. (d) 34. (c) 35. (b)
36. (a) 37. (a) 38. (c) 39. (c) 40. (c)
41. (a) 42. (c) 43. (d) 44. (a) 45. (b)
46. (a) 47. (b) 48. (a) 49. (a) 50. (a)
20 MCQs in Pharmaceutical Sciences

51. (b) 52. (a) 53. (d) 54. (d) 55. (b)
56. (c) 57. (c) 58. (a) 59. (c) 60. (a)
61. (a) 62. (b) 63. (c) 64. (b) 65. (a)
66. (c) 67. (b) 68. (c) 69. (d) 70. (a)
71. (c) 72. (c)
 Pharmaceutical Technology 21

1. Department of Transport Test (DOT) (b) Good-hue

is performed for which of the (c) Sullivan
following? (d) Franklin
(a) Aerosols
(b) Glass containers 7. The first pharmaceutical aerosol was
(c) Capsules developed in the year of
(d) None (a) 1945 (b) 1949
(c) 1955 (d) 1960
2. Measurement of particle size in
pharmaceutical aerosol is by 8. Which drug is formulated as first
(P) Cascade impactor pharmaceutical aerosol?
(Q) Light scatter decay (a) Epinephrine
(R) K-F method (b) Codeine
(S) IR (c) Chloropromazine
(a) P, Q (b) Q, R (d) Probenecid
(c) R, S (d) P, S
9. To dispense inhalation aerosols, which
3. Identify the correct non-flammable containers are used?
propellant
(a) Stain less steel containers
(a) Trichloro monofluoro methane
(b) Tin plate containers
(b) Dichloro monofluoro methane
(c) Glass containers
(c) Di methyl ether
(d) Al containers
(d) Di fluoro methane
4. The dip tube in an aerosol container is 10. The valve body /housing in a aerosol
made from one of the following bottle valve assembly, is made from
(a) Poly propylene one of the following
(b) Glass (a) Nylon
(c) Al (b) Poly propylene
(d) Stainless steel (c) Poly ethylene
(d) Stain less steel
5. Which one of the following device is
used to increase the efficiency of drug 11. The equipment listed P-T is used for
delivery via aerosols? the identification of properties of
(a) Tube spacers aerosol mentioned below. Match them.
(b) Metered valves 1. Particle size determination
(c) Actuator (P) Pycnometer
(d) Pressure valve 2. Identification of propellants
(Q) Rotaional viscometer
6. The first aerosol insecticide was
3. Stability of foam
developed by
(R) Tag open cap apparatus
(a) Good-hue & Sullivan
22 MCQs in Pharmaceutical Sciences

4. Flash point 15. The identification of propellants in

(S) IR spectroscopy pharmaceutical aerosols is carried out
(T) Cascade impaction by
(a) 1-P, 2-Q, 3-R, 4-S (P) Gas chromatography
(b) 1-Q, 2-P, 3-S, 4-T (R) Pycnometer
(c) 1-T, 2-S, 3-Q, 4-R (Q) Tag open cup apparatus
(d) 1-R, 2-S, 3-P, 4-Q (S) IR spectrophotometer
(a) P,Q (b) P,S
12. Match the coatings given below with (c) Q, R (d) R, S
their corresponding techniques listed
P-T 16. Aerosol packaging container must
1. Compression coating resist pressure of
(P) Air in the coating pan is (a) 500 psig
replaced with Nitrogen (b) 140-180 psig
2. Dip coating (c) 40 psig
(Q) Application of coating to (d) 20 psig
conductive substrates
3. Electrostatic coating 17. Gasket is made up of
(R) Acid insoluble coating (a) Bure-N
4. Vacuum film coating (b) Neoprene rubber
(S) A tablet within a tablet (c) Both
(T) Replaced coating & drying (d) All
(a) 1-T, 2-R, 3-Q, 4-P 18. Manufacturing of aerosol involves
(b) 1-Q, 2-R, 3-S, 4-T (a) Gas filling
(c) 1-P, 2-R, 3-T, 4-S (b) Pressure filling
(d) 1-R, 2-T, 3-P, 4-Q (c) Compressed gas filling
(d) All the above
13. Among the propellants used in
aerosols, one of the following is used 19. The nature of propellant is determined
for topical pharmaceutical aerosols by
(a) Tri chloro monofluoro methane (a) R-F method
(b) Di chloro difluoro methane (b) Gas Chromatography
(c) Di chloro tetrafluoro ethane (c) UV
(d) Propane (d) None
14. Which one of the following propellant 20. Viscosity enhancer in ophthalmic
is used in the aerosol for oral use preparation is
(a) Propane (a) Poly vinyl alcohol
(b) Oxygen (b) Povidone
(c) Methane (c) Dextran
(d) Trichloro monofluoro methane (d) Macrogol
 Pharmaceutical Technology 23

21. pH of human tear is (d) Bacterial filters

(a) 7.2 (b) 8
(c) 7.6 (d) 4.6 23. Which of the following one is used to
adjust the isotonicity
22. Opthalmic solution is sterilized by (a) Dextrose
(a) Autoclave (b) Boric acid
(b) Hot air oven (c) NaCl
(c) Both (d) All the above

KEY

1. (a) 2. (a) 3. (a) 4. (a) 5. (b)

6. (a) 7. (c) 8. (a) 9. (a) 10. (a)
11. (c) 12. (a) 13. (d) 14. (d) 15. (b)
16. (b) 17. (c) 18. (c) 19. (b) 20. (d)
21. (c) 22. (a) 23. (d)