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Which one of the following is true about DIC?

A. It is a phenomenon of extensive platelets aggregation
B. It is the result of activated fibrinolysis
C. It belongs to secondary bleeding
D. It always leads to acute and extensive microthrombosis
E. It is an imbalance between blood coagulation and anticoagulation


Schistocyte is irregular fragment of

A. Red blood cell (RBC) B. WBC
C. Platelet D. Endothelial cell
E. Mononuclear phagocyte


The key step for the pathogenesis of DIC is

A. Activation of factor ? B. Tissue factor expression
C. Formation of thrombin D. ADP releasing
E. Activation of fibrinogen


Why does mononuclear phagocyte system dysfunction influence the development of DIC?
A. It may promote the production of procoagulant substances
B. Its clearance function is reduced
C. It may accelerate fibrinolysis
D. It may release lots of tissue factor
E. It may damage vascular endothelial cells

In what kind of DIC can the depletion of coagulation factors exceed their replenishment?
A. Decompensated DIC B. Chronic DIC
C. Overcompensated DIC D. Compensated DIC
E. Subacute DIC


Which one of the following statements is true about ischemia-reperfusion injury?

A. Tissue injury caused by ischemia
B. Tissue injury caused by reperfusion
C. A consequence caused by recovering the blood perfusion of ischemic tissue
D. Phenomenon of the ischemic damage aggravated by recovering the blood perfusion of ischemic
E. None of above


Which one of the following reperfusion condition may aggravate reperfusion injury?
A Slower reperfusion speed B. Lower perfusion pressure
C. High temperature D. Lower pH
E. Lower concentration of sodium and calcium


Free radicals attack the following cellular components except

A. Membrane lipid B. Protein C. DNA
D. Electrolyte E. Mitochondria

The basic characteristics of myocardial stunning after ischemia- reperfusion is

A. Cardiomyocyte necrosis
B. Delayed recovery of metabolism
C. Delayed recovery of structure changes
D. Delayed recovery of contractile function
E. Immediately recovery of cardiac function


Which one of the following proteases can promote the conversion of xanthine dehydrogenase to
xanthine oxidase?
A. Calcium-dependent protease B. Magnesium-dependent protease
C. Copper-dependent protease D. Zinc-dependent protease
E. Sodium-dependent protease


Which one of the following statements is right about G protein?

A. G protein is activated after binding to ligand
B. G protein has GTPase activity
C. The GDP bound form of G protein is the active one
D. GEF is a negative regulator of G protein
E. G protein has a 7-transmembrane structure


Which one of the following signal transduction pathway cannot be activated by GPCR?
A. PKA pathway B. Smad pathway
C. MAPK pathway D. PKB pathway
E. PLC pathway


Which one of the following statements about Ras is not right?

A. Ras can degrade GTP to GDP
B. Ras belongs to G protein family
C. Increased GTPase activity of Ras can lead to the over proliferation of cells and the
development of cancer
D. Receptor tyrosine kinase activates Ras through the interaction with adaptor protein
E. The downstream Ras is a MAKKK


The activation of Smad requires

A. The function of Gs B. camp
C. Phosphorylation D. Ras E. JAK


B isWhich one of the following statements about NF- right?

A. Translocation to nucleus is required for the activity of BNF-
BB. Phosphorylation is required for the activity of NF-
C. Under B is bound to its inhibitor protein IKK, thus is notnormal circumstance NF- active
D. Ubiquitin-mediated degradation of IKK is required for the Bactivation of NF-
E. As a protein kinase, IKK can phosphorylate BNF-


Which one of the following is incorrect about apoptosis?

A. It is a ubiquitous biological phenomenon
B. It is a process of cell initiative death
C. This kind of cell death is controlled by gene
D. This process does not consume energy
E. There is no inflammatory response in apoptotic region


Which one of the following is incorrect about physiologic or pathophysiologic significances of

A. To maintain organism's normal developments
B. To clean up nonfunctional cell
C. To promote organic evolution
D. To maintain homeostasis
E. To participate in the defensive reaction of the organism


Which one of the following is incorrect about apoptotic signal transduction?

A. Different kinds of cells have different signal transduction systems
B. The same signal can induce apoptosis or proliferation in different conditions
C. Different apoptotic inducing factors can induce the same signal transduction systems and then
lead to apoptosis
D. The same apoptotic inducing factors can induce apoptosis in different signal transduction ways
E. There is no cross-way among apoptosis, proliferation and differentiation


The main executors of apoptosis may be

A. Endonuclease and calmodulin
B. Nuclear factor and endonuclease
C. Endonuclease and some caspases
D. Nuclear factor and some caspases
E. Some caspases and transglutaminase

Which one of the following diseases is relevant to apoptosis-insufficiency?

A. Parkinson's disease
C. Chronic thyroiditis
D. Cardiac failure
E. Myocardial infarction