IntravenousFluidComparisonTableforLargeVolume,IntravenousSodiumChloride0.

9%(NormalSaline)Shortage*18
Glucose Osmolarity
Product pH (g/L) Na+ K+ Ca++ Mg++ Cl Lactate Acetate Gluconate (mOsmol/L)
5.5
Sodiumchloride0.9% 154 154 308
(4.5to7)

4
Dextrose5% 50 252
(3.2to6.5)
4
Dextrose5%andsodiumchloride0.2% 50 34 34 321
(3.2to6.5)
4
Dextrose5%andsodiumchloride0.45% 50 77 77 406
(3.2to6.5)
6.5
LactatedRingerssolution 130 4 2.7 109 28 273
(6to7.5)
5.5
Sodiumchloride0.45% 77 77 154
(4.5to7)

7.4
PlasmaLyteA 140 5 3 98 27 23 294
(6.5to8)
5.5
PlasmaLyte148 140 5 3 98 27 23 294
(4to8)
5
PlasmaLyte56anddextrose5% 50 40 13 3 40 16 363
(4to6.5)
*IonicvaluesarelistedasmEq/L;unitsofmeasureforotheritemsareotherwiseindicated;
ListedvaluesdonotincludeionsfromhydrochloricacidorsodiumhydroxideutilizedaspHbufferingagents

ClinicalPoints
Considerconservationmeasureswhereclinicallyappropriate(ie,useofsmallervolumes,alternativefluids,oralreplacement)
Theitemsabovedonotrepresentanallinclusivelistofavailablecrystalloidorcombinedelectrolyteproducts
Normalphysiologicosmolarityrangesfrom280to310mOsmol/L4,68,10
Acompounded1litersolutionofsodiumbicarbonate150mEq(1mEq/mL)insterilewaterhasanosmolarityofapproximately300mOsmol/L9,10
Acompounded1litersolutionofsodiumbicarbonate150mEq(1mEq/mL)indextrose5%hasanosmolarityofapproximately514mOsmol/L9,10
Solutionsabove(eg,lactatedringers,PlasmaLytesolutions)shouldnotbeusedinpatientswithmetabolicalkalosis59
PreparedbyMUSCDrugInformationServices
January2014


References
1. CombinedElectrolyteSolutions.In:DrugFactsandComparisons.[Internet].Indianapolis(IN):WoltersKluwerHealth;2014.[updated2007
August;cited2014January23].Availablefrom:http://online.factsandcomparisons.com/MonoDisp.aspx?monoid=fandchcp13845&book=DFC.
2. Sodiumchlorideinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;September2013[cited2014January23].Available
from:http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/016677s147,016693s096,018016s061lbl.pdf
3. Dextroseinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;January2014[cited2014January23].Availablefrom:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3bb406a9f5cb403ab1bb5c4facbea3d5
4. Dextroseandsodiumchlorideinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;September2013[cited2014January23].
Availablefrom:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/016678s105,016697s096,016689s105,016696s097,016683s100,016687s102lbl.pdf
5. LactatedRingersinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;November2011[cited2014January23].Availablefrom:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=dad7735c709b40eaab7a15577e24a966
6. PlasmaLyteAinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;September2013[cited2014January23].Availablefrom:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6ec9e61c2c26402f8604f446b2e34058
7. PlasmaLyte148injection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;September2013[cited2014January23].Available
from:http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7eee0bda06d84cc485e97c6e4801f09c
8. PlasmaLyte56anddextroseinjection[PackageInsert].Deerfield,IL:BaxterHealthcareCorporation;September2013[cited2014January23].
Availablefrom:http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=85c08b628de042d28cdcfe42e6b605d7
9. Sodiumbicarbonateinjection[PackageInsert].Schaumburg,IL:APPPharmaceuticals,LLC;August2012[cited2014January24].Availablefrom:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f6043eddd19b43fba44205f3503226fd
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cited2014January24].Availablefrom:https://www.musc.edu/medcenter/osmcalc/index2.htm

PreparedbyMUSCDrugInformationServices
January2014