Escolar Documentos
Profissional Documentos
Cultura Documentos
Pen G,V
-lactams Penams
Ampicilin/amoxacilin
Piperacilin/tazobactam
(ticarecillin)
Nafcilin, oxacillin,
dicloxacillin (oral)
Cephalexin
cefuroxime
Cell wall Antibiotics
Cephalosporins ceftriaxone/ceftazidime
cefepime
meropenem
Carbapenems
imipenem
monobactam azteronam
Vancomycin vancomycin
gentamicin
aminoglycosides (STAG
ag)
tobramycin (CF)
streptomycin
amikacin
erythromycin
clarithromycin
Macrolides
azithromycin
Inhibitors of protein
synthesis AteML
(ribosome attach, A, AP,
MAO) (Buty AT 30 and
Macrolides
Inhibitors of protein
synthesis AteML clindamycin
(ribosome attach, A, AP,
MAO) (Buty AT 30 and
CCEL (ML) at 50)
tetracyclin
tetracyclines (TeTiDoCo)
tigecycline
doxycycline
coxycycline
oxazolidinoes linezolid
rifampin rifamipin
ciprofloxacin
levofloxacin
Fluroquinolones
Inhibit nucleid acid moxifloxacin
metabolism ready for
metabolism
metronidazole metronidizole
sulfamethoxazole
sulfonamides
Antimetabolites CUPS
(COtrimethoprim treats
UTI and Pnumocystis, dapsone
with Steven Johnson)
trimethoprim
(dihydrofolate reducase trimethoprim
inhibitor)
Isoniazid Isoniazid
rifampin rifampin
Metronidizole,
Imipenem, I MET the PIPER at the
Anerobic coverage/B Meropenem, TICket office to buy my
fragelis Amoxaciliin/ AMOr some ClauMeroImi
Clauvulanate, Ticarcilin,
and piperacilin
BBB
Anerobes
Aerobes
renal vs hepato
clearance
UTI
Quick note/remember this by! method of intake
IM, IV only, the OG. V is oral version pretty much IM/IV Oral
oral
TB, hepatotoxic, fatty acid inhibition
oral
Ethambutol Macrolides
bacteria it treats Activity spectrum
S Aureus
better at gm + than gm -
Bactericidal (only towards
HENS PEcK growing)
Anerobes, fragilis
Gm + only Bactericidal
Bactericidal
TB
Both
TB
Static
Bactericidal
Mechanism mechanism of resistance
Prevent A--> P movement in ribosomes, phagocytes will carry efflux (mefA/E gene), target site
them to the site, 50S subunit methylation (erm gene)
inhibitor of protein synthesis, 50s C diff, efflux, target site methylation
Inhibits 30S unit at A site to prevent first tRNA binding Gm -, increased efflux, altered 30S target
blocks dihydrofolate
drug toxcitiy, ototoxicity, nephrotoxicity, narrow stuff Very low volume of distribution, unchanged in
Urine, small theraputic window
peripheral neruopathy (prevent with pyridoxine), Well abosorbed with good penetration. 80-180
bone marrow suppression, optic neruitis, half life so there needs to be daily dosing.
hepatotoxicity, GI intolerance, inhibits metabolism Aceylated metabolites apear in urine
through phenytoin
hyperuricemia, non-gouty polyarthralgia,
hepatotocicity, GI intolerance, gout
well abosrbed in GI, widely distributed,
excreted by glomerular filtration
optic neuritis, Gi intolerance, gout, peripheral
neuropathy, confusion and diziness, interstitial
nephritis 8 hour half life
orange coloration of bodily fulids, GI intolerance, well abosrbed, de-acylated by liver, extensive
Hepatotoxicity, flue like, drug interactions (induces enteropathic cycling, only 20% in urine
P450) --> decreased effacacy of other drugs
Notes
Well tolerated
lyme disease, preferred for patients with
imparied renal function
it gets changed
EAEC biofilms
EIEC
MNEC
rod, single flagellum, obligate aerobe cytochrome C pili, LPS, elastase, Exotoxin A (ADP ribosylation of
EF2), type III to Block phagocytosis, pyocyanin,
encapsulated oxidase +, oxidizes sugars alginate, hemolysins, efflux, catalase +
cystitis, peylonephritis
Nafcillin if it is meticilin-sensitive,
Vancomycin for MRSA to combate altered
PBP, daptomycin, linezolid
neonates
Piperacilin, Aminoglycolyses,
FQN,ceftazidime, cefepime, azteronam,
imipenam