PC 311; Medicinal Chemistry-1

The students will be aware about the

chemical structure of the
pharmaceutical compounds and the
structure activity relationship of
these compounds and their
biological applications. Develop the
students understanding and
appreciation of the drug design and molecular modeling and how they save time,
coast and minimizes the side effect of drugs. Develop and enhance student thinking
to the proper and ideal use of the drugs.
Prerequisites: PC 311: Organic Chemistry (PC 101 and PC 202). - Analytical Chemistry
(PC 101 and PC 202). Inorganic Chemistry and Physical Chemistry (PC 101)
Biochemistry (BCH P 201) Pharmaceutics I & II (PH 211 & 312) Principles of
Physiology (PHY 201 P) Basics of Microbiology (MIC 301).

Course objectives:
1. To predict the relation between the physicochemical properties and drug
action.
2. To identify different covalent and/or non-covalent forces involved in drug
receptor interaction and their relation to drug-duration of action.
3. To deal with any given structure, analyze it, and extract essential structures
features and pharmacophores and their relations to drug activity.
4. To rationalize the different phases of drug biotransformation.
5. To identify the different classes of chemotherapeutic agents.
6. To identify the origin, molecular modifications and molecular mode of actions
of different classes of antibiotics including cell-wall synthesis inhibitors and
protein synthesis inhibitors.
7. To explore the mechanism of action and identify the structure and medicinal
application of antiviral, antineoplastic, antiparasitic drugs (including
antifungal, antimalarial and anthelmintic), antiseptic and disinfectant drugs.
8. To be able to deal with computer programs specialized in presentation of
drug molecules in Two-dimensions and Three-dimensions and derive certain
necessary information.
9. To become able to make a decision for the selection of the proper drug(s)
needed in a selected case study.

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Course Outcomes
On completion of this course, the student will be have a good idea about some drug
categories and their application in medicinal field and he also started to have an
experience about the relation between the structure and its activity, he can
differentiate between the potency and toxicity, so the student can be familiar with
drugs administration and avoiding drug interactions.

Learning Resources:
Foye's Principles of Medicinal Chemistry, D. A. Williams and T. L. Lemke, sixth
edition, Lippincott Williams & Wilkins, 2008.
Textbook of Organic Medicinal and Pharmaceutical Chemistry. (Wilson and
Gisvold's), J. N. Delgado, W. A. Remers. Lippincott - Revan Publishers, 1998.
Introduction to Medicinal Chemistry, G. Patrick, second edition, 2002.
Handout Lecture Notes and /or CDs may be supplied to you.
Computer Programs:
Chem. Draw ultra 8.0.
DS Viewer Pro (Accelyr's).
Reading handouts shall be available.

Teaching Methods:
Lectures:
The lecture is still the norm for presenting scientific knowledge. It is instructor's
experience that many people learn best by having the information explained directly
to them, as compared to only reading about it in the text. The taking of accurate
notes helps to reinforce what is said. As Medicinal chemistry is very systematic and
logical; the lectures illustrate these features and you make your own connections to
facilitate long-term learning.

Tutorial Classes:
Tutorial classes will provides you with a simple and complete understanding of drugs
and their different classes, in addition to their reaction mechanisms and also their
physical and chemical properties and their effect on the bioavailability and the
biological action of these drugs starting from their administration until their
metabolism and excretion. In order for the design of this class to work, you all must
be actively involved in the class. First, you should attend. Second, you should have
read and thought about the material. Third, you should be willing to share your
thoughts and ideas to enhance your own and others learning. Please, realize that its

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ok to be wrong. What I mean by this is if you try to answer a question, and your
answer is incorrect, there is a good chance you are not alone! By seeing the wrong
answers and understanding why they are wrong, we ALL learn. Of course, wrong
answers on exams still carry a penalty (that is why they are so valuable in class). If
you have any questions about your class participation, please contact your lecturer.

Practical sessions:
The medicinal chemistry laboratory has as main emphasis the development of
specific skills and techniques important to the area. Because one must learn a skill by
personal experience, most of the work is done individually and not with partners.
However, exchange and discussion of experimental results is part of most labs. The
laboratory reinforces the lecture by showing the students how the information in the
text was obtained.

Using supplemental teaching materials

Such as CDs, self-assessment tests, interactive learning tools and homework.

Problem-solving learning
To overcoming obstacles by generating hypotheses, testing those predictions, and
concluding a satisfactory solution

Cooperative learning
In which small teams, each with students of different capability ability levels, uses a
variety of learning activities to improve their understanding of a subject.

Involve students in simple research projects

To develop skills of scientific research and active participation in the scientific
conferences by papers and posters

Field visits
To pharmaceutical factories and research centers to gain practical skills and to
link the theoretical aspects of reality; writing reports on the consequences of
these visits

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Assessment:
Graded assignments for this course will include a mid-term exam, a comprehensive
final exam, and 13 laboratory reports. All graded assignments will be scored on a
100-point scale. Course grades will likewise be computed on the following scale:

Two Periodical exams (20%) 30 points

Two Laboratory exams (24%) 36 points
Med. Year exam (28%) 42 points
Final exam (28%) 42 points
TOTAL 150 points

The final word grade assigned to you will be based upon the following numerical
equivalence
A+ = 95 100 %
A = 90 94 %
B+ = 85 89 %
B = 80 84 %
C+ = 75 79 %
C = 70 74 %
D+ = 65 69 %
D = 60 64 %
F = 0 59 %
To pass the grading scale you should gain not less than 60%

The written exams include a mixture of MCQs, short answer-questions (SAQs),

extended matching questions (EMQs) and problems-solving exercises. The Answers
are will be presented and discussed immediately with you after the assessment. The
results will be made available to you.