Blood glucose concentration

constant 8.4

Glucose input rate Q eating 12
variable
not eating 2

x , x 7.2
Renal loss rate R with
0, x 0.78

Insulin independent rate Gindep x with 2.47

Insulin dependent rate Gdep vxy with v 139

Q R Gindep Gdep
dx
Rate of change of glucose
dt

Insulin concentation
14
Insulin production rate P x with
0.51

Insulin destruction rate D y with 76

dy
Rate of change of insulin PD
dt

B. ( 16 points ) GlucoseConstant_EulerForward.m, GlucoseVariable_EulerForward.m,

GlucoseConstant_ModifiedEuler.m, and GlucoseVariable_ModifiedEuler.m are computational
simulations for all 4 combinations of a constant glucose input versus a variable glucose input using
Eulers forward and modified Euler methods.

In all 4 cases, using too small of a time increment makes the simulation take a long time to run. Using
too large of a time increment leads to instability. Find the largest time increment that can be used for
each case that does not lead to increasing amounts of instability.

C. ( 3 points ) Compare the equilibrium values for glucose and insulin for all three cases of glucose input
from the computational models to the values calculated in part (a).
2. Create and analyze a computational model for a physiologic system.

A. ( 2 points ) Describe the physiologic system.

B. ( 2 points ) What equations can be used to form a computational model of the physiologic system?

C. ( 3 points ) Analytically solve for equilibrium values for the system.

D. ( 9 points ) Write a computational model for the physiologic system with constant inputs. Does the
model converge to the equilibrium calculated in part (c)? Submit both your Matlab script and an
example plot of results from your model.

E. ( 9 points ) Modify the model for variable inputs. Submit both your Matlab script and an example plot of
results from your model.