PAT H O P H Y S I O L O G Y

PR E C I PITATI N G F CONTRIBUTING PREDISPOSING

ACTORS FACTOR S FACTOR S

- Age : 77 years old NSAIDs use -Stress

-Diet: spicy food,
coffee addict

Elicit their effects on the

cyclooxygenase-1

Impaired mucosal defense

to acid

Disruption of mucous
barrier

Inflammatory effect on Neutrophils: .86%

gastric mucosa

Ulcer burrows deep

Weakening and necrosis of

arterial wall

Development of
pseudoaneurysms

Peripheral Weakened wall raptures

vasoconstriction leading to hemorrhage

Pale nail beds

and conjuctiva UPPER GASTROINTESTINAL
BLEEDING

- Generalized BP: 130/70

Body Weakness RR: 21
- Dizziness CR: 80