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European Journal of Cardiovascular Nursing 1 (2002) 195201

Anxiety and well-being in first-time coronary angioplasty patients and


repeaters
Mattie J. Lenzena,*, Claudia J. Gamelb, Atie W. Imminka
a
Department of Cardiology, Thoraxcenter, Erasmus MC, Dr. Molewaterplein 40, 3015GD Rotterdam, The Netherlands
b
Department of Nursing Science, UMC-Utrecht and Faculty of Health Care, Hogeschool van Utrecht, Utrecht, The Netherlands

Received 14 January 2002; received in revised form 1 May 2002; accepted 17 July 2002

Abstract

Introduction: Preparatory information before an invasive procedure has positive effects (e.g. on recovery, well-being and
anxiety). However, preparation of patients for a repeat procedure is hardly investigated. The question is whether these patients
benefit from the same preparatory information. Aims: To determine whether there are differences in terms of anxiety and well-
being between patients undergoing their first percutaneous transluminal coronary angioplasty (PTCA) and those undergoing a
repeat PTCA. Design: Descriptive correlational study with a quantitative and qualitative research component. Method: First-time
PTCA patients (ns46) and re-PTCA patients (ns40) were asked to complete three psychological self-report questionnaires
(HADS, HPPQ and VAS) before the procedure. Five re-PTCA patients were interviewed the day after the procedure. Results: We
were not able to show statistically significant differences between the two groups. On the anxiety scales re-PTCA patients scored
6.5 (HADS) and 4.0 (VAS) vs. 5.0 (Ps0.25) and 2.6 (Ps0.30) for first-time PTCA patients. On well-being (HPPQ) these
differences were 18.0 vs. 19.0 (Ps0.40). Once the interview data were coded, four themes were apparent, namely: recurrent
symptoms, information, experience and future prospects. Conclusion: A trend is seen towards a worse condition in the re-PTCA
group with respect to anxiety and well-being. However, the differences are not statistically significant, they seem to be clinically
relevant. The interviews point out that the return of symptoms and future prospects, rather than the procedure itself, are an
important part in preparing for a repeat intervention. This aspect is currently no part of the provided preparatory information.
Future research will have to determine the most beneficial method of preparing these patients (e.g. tailored preparation, emotional
support, coaching).
2002 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.

Keywords: Anxiety; Well-being; Angioplasty; Repeat intervention

1. Introduction dramatic developments and these have made it possible


to treat increasingly complex single-vessel and multi-
Treating angina pectoris, an ischemic heart disease vessel diseases w1x. Comparative medical studies on
caused by coronary sclerosis, is a major focus in death, morbidity and the need for re-intervention in
cardiology. Coronary sclerosis is a chronic and often CABG and PTCA patients reveal no significant differ-
progressive disease. Over the past decades, tremendous ence in death and morbidity. PTCA patients, however,
progress has been made in the methods of treatment. In have a greater need for re-intervention w2x. When a
addition to medication therapy, invasive techniques have repeat intervention is indicated, the question arises as to
been developed to achieve revascularisation: coronary whether these patients should receive the same type of
bypass surgery (CABG) was introduced in the late preparation as patients undergoing their first inter-
1960s and percutaneous transluminal coronary angio- vention.
plasty (PTCA) in the late 1970s. PTCA has undergone An important part of preparing patients for an invasive
*Corresponding author. Tel.: q31-10-4632891; fax: q31-10-
procedure, such as an operation, a diagnostic examina-
4089484. tion or a PTCA, is the provision of information. The
E-mail address: lenzen@card.azr.nl (M.J. Lenzen). presented information, in whichever form of transmis-

1474-5151/02/$ - see front matter 2002 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.
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196 M.J. Lenzen et al. / European Journal of Cardiovascular Nursing 1 (2002) 195201

sion, should consist of procedural, sensory and behav- 2. Patients and methods
ioural information w35x. After receiving preparatory
information, the patient is less likely to make his own
A cross-sectional, descriptive, correlational study with
(wrong) interpretation about what he is facing. A wrong
a quantitative (first research question) and a qualitative
interpretation paves the way for imaginary fantasies of
(second research question) research component was
fear w6x. Measurable effects have been observed on used because of the nature of the research questions.
recovery, well-being, and a reduction in anxiety if the Ethics committee approval of the study was obtained.
preparatory information consists of procedural, sensory All patients consecutively admitted to the Department
and behavioural information w713x. Although the spe- of Cardiology at the Academic Hospital of Rotterdam
cialist is responsible for providing a large part of this for an elective planned PTCA as a result of an ischemic
information, it is becoming increasingly more common coronary disease between the month of May and August
for the nursing staff to prepare patients for invasive 2000 were invited to participate in the study if they had
procedures and surgery w14x. More than 35 years after sound knowledge of Dutch. From a total of 96 admis-
the first nursing research article by Dumas and Leonard sions for an elective PTCA, 86 met the inclusion criteria.
w15x, preparation remains a highly topical subject, not
Ten patients were not eligible due to language problems
only in the daily practice but also in nursing research. or participation in another study. Written informed con-
As briefly mentioned, a number of PTCA patients sent was obtained from all 86 patients.
require repeat intervention. If these patients benefit from
the same preparatory information is hardly investigated
w4,1618x. Most of the studies concerning preparatory 2.1. Data collection methods
information focus on patients who have had no previous
experience with a specific medical procedure w912x. Three questionnaires were given to the respondents
The studies that do focus on previous intervention w16 before preparatory information was provided, however,
18x do not clarify whether patients undergoing a repeat they were asked to fill in the questionnaires after the
intervention need the same or different preparation as information was provided. The questionnaires had to be
patients undergoing their first intervention. Although returned before the procedure. The questionnaires were
these studies did not provide information with respect the (1) hospital anxiety and depression scale (HADS)
to the way patients should be prepared for a re-interven- w19,20x; (2) the heart patients psychological question-
tion, they addressed a number of quantifiable effects of naire (HPPQ) w21,22x; and (3) a visual analogue scale
preparatory information in general. As these studies (VAS) w2325x. These questionnaires measure outcomes
shown a relationship between preparatory information that are frequently targeted when preparing patients for
and measurable outcomes (e.g. recovery, anxiety and threatening procedures. Also these outcomes are consis-
well-being), the aim of the present study was to inves- tent with the theoretical framework (Leventhal and
tigate whether there are measurable differences between Johnson) of this study.
first-time intervention patients and repeat intervention The HADS measures anxiety and depression in a
patients. We hypothesised that if re-PTCA patients had hospital environment. The 14 items in the questionnaire
a worse score on anxiety and well-being, this may are grouped in two sub-scales: Anxiety (7 questions)
indicate that these patients do not benefit equally from and Depression (7 questions). Patients choose among
the method of preparation used. Secondly, we aimed at four possible answers, which are assigned a value (0
gaining insight into the way in which patients prepare 3). For each sub-scale, a minimum score of 0 and a
themselves for a repeat intervention. With respect to maximum score of 21 points is possible. The higher the
these aims, two research questions were formulated. score, the higher the level of anxiety or depression. A
First, is there a quantifiable difference in pre-operative score 08 indicates at least borderline anxiety or depres-
level of anxiety and well-being between patients under- sion w19x.
going PTCA for the first-time and patients who have The HPPQ measures the mental well-being of heart
already undergone a PTCA? Second, how do patients patients. It contains 52 items which patients rate on a
prepare themselves for a repeat PTCA? Because the three-point Likert scale (13). Forty of the 52 items are
self-regulation theory of Leventhal and Johnson w7x is distributed among four sub-scales: Well-being (12 items,
frequently used when preparing patients for their (first) score range 1236); Feelings of disability (12 items,
intervention, this theory was chosen as the theoretical score range 1236); Despondency (10 items, score
framework of this study. The self-regulation theory range 1030); Social inhibition (6 items, score range
clarifies the processes and effects of preparatory infor- 618). A high score in feelings of disability, despon-
mation that consists of procedural, sensory and behav- dency and social inhibition indicates a worse condition,
ioural information as well as coping instructions. with, respectively, 33, 21 and 14 as cut-off points. The

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M.J. Lenzen et al. / European Journal of Cardiovascular Nursing 1 (2002) 195201 197

opposite applies to the well-being dimension: the lower Table 1


the score the poorer the condition (cut-off point is 14) Basic characteristics of the sample size
w21x. Total 1e-PTCA re-PTCA P-value
The VAS is particularly suitable for measuring the ns86 ns46 ns40
intensity of subjective sensations, such as pain, fatigue,
Age in yearsa 60 60 (53y72) 58 (53y71) 0.61
or anxiety in patients with a heart disease w24x. A VAS Male 71% 65% 77% 0.21
consists of a line, 100-mm in length. At each end of the Waiting period in weeksa 4.7 4.0 (3y6) 5.0 (3y6) 0.56
line are anchors, which represent the extremes of the CABG 21% 13% 30% 0.05
sensation under study. The patient is asked to mark a a
Median scores, measure of variability is given in 25th and 75th
point along this line. In the present study: I dont feel percentile.
anxious at all and I feel extremely anxious were used
as anchors. The interviews were analysed according to the
An interim analysis of the results obtained with the approach described in the grounded theory w27x because
HADS and HPPQ was performed in order to select this method best suited the research question. Based on
which repeat PTCA patients to approach for an interview symbolic interactionism, this theory takes reality to be
(in order to answer the second research question). The that which the respondent perceives and experiences as
results with the first 24 patients revealed a significant being real. The interviews were analysed by transcrip-
difference in well-being (HPPQ) in first-time and repeat tion, open coding, selective coding w25x, and finally a
patients. Five patients, 2 with a low well-being score number of concepts in development w28x were identi-
and 3 with a high well-being score were asked for the fied. In the findings, these concepts in development are
interview which took place the day after the procedure. labelled by themes for practical purposes. Conform with
All agreed to participate. A semi-structured interview ensuring reliability and validity in qualitative research
technique was used w25x. The patients were confronted the following procedures were followed: one interviewer
with the same opening question: how did you feel did all interviews, interviews were recorded and tran-
about having to undergo another angioplasty? The scribed, analysis and interpretations were discussed with
following topics were explored: previous procedure, colleague researchers (peer debriefing).
approach by nurses and physicians, assistance with
preparation, influence of previous procedure, need for 3. Results
information, influence of symptoms and future pros-
pects. The topics assistance with preparation and need A total of 86 patients were enrolled in the study.
for information provided the opportunity to explore Characteristics of these patients are listed in Table 1.
preparation in the terms of the Leventhal and Johnson The sample was predominantly male (71%). The median
framework. age of the total group was 60 years, and waiting period
in weeks for the intervention was 4.7 weeks. A little
less than half of the respondents (47%) were admitted
2.2. Statistical analysis
to undergo a repeat intervention and 18 respondents
(21%) had previously undergone a bypass operation
For the quantitative analysis, SPSS for Windows (ver- (CABG). Statistical analysis of the basic characteristics
sion 9.0) was used. Data obtained on a nominal level of the two groups, 1e-PTCA and re-PTCA, did not
(among others, the basic characteristics of the sample) reveal any significant differences in age, gender and
were analysed with Pearsons x2-test. If the numbers waiting period for the intervention. However, the number
per cell were smaller than 5, Fishers Exact was used. of CABG operations in the respondents undergoing their
The results obtained with the HADS, HPPQ and VAS first PTCA is smaller than in the re-PTCA group (Ps
were all on an interval level. Distribution was assessed 0.05).
with the KolmogorovSmirnov test. Since a normal All respondents (ns86) completed and returned the
distribution was not found, a non-parametric method of questionnaires. Two respondents (one from each group)
analysis was used, namely the MannWhitney test. The did not entirely complete the HPPQ. As their sub-scale
study results are therefore expressed in median values, scores could not be calculated, the HPPQ questionnaires
and distribution is given in the first (P25) and third from these patients were excluded from analyses. Medi-
(P75) quartiles. A P-value of -0.05 (two-sided) was an scores are presented in Table 2.
considered statistically significant. The anxiety score (HADS) shows a trend towards a
As dividing males and females is recommended in worse condition in re-PTCA patients (Ps0.25).
studies involving psychological questionnaires w26x A comparison between the two groups reveals a
these data were analysed separately for each gender. It slightly lower degree of well-being (HPPQ) in the re-
should be noted however, that exploring gender differ- PTCA group (Ps0.40). The measure of feelings of
ences was not planned before data collection. disability (HPPQ) demonstrates that there is a clear

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198 M.J. Lenzen et al. / European Journal of Cardiovascular Nursing 1 (2002) 195201

Table 2
Differences between the 1e-PTCA and re-PTCA groups

Variables 1e-PTCA (ns46) re-PTCA (ns40) P-value


HADS Anxiety 5.0 (4.0y8.0) 6.5 (5.0y10.0) 0.25
Depression 5.0 (3.0y6.0) 4.5 (2.0y8.0) 0.73
HPPQa Well-being 19.0 (15.0y24.5) 18.0 (14.0y23.0) 0.40
Disability 33.0 (28.0y34.0) 32.0 (29.0y35.0) 0.88
Despondency 16.0 (13.0y19.5) 17.0 (14.0y22.0) 0.30
Social inhibition 11.0 (9.0y15.0) 11.0 (8.0y14.0) 0.62
VAS 010 cm 2.6 (0.7y6.4) 4.0 (1.2y6.0) 0.30
Median scores, measure of variability is given in 25th and 75th percentile.
a
HPPQ analysis is based on 84 questionnaires because two respondents (one from each group) did not entirely complete the questionnaire.

discrepancy between the desired and actual ability in a given borderline value in the re-PTCA group than in the
large percentage of the respondents (in both groups). 1e-PTCA group (Ps0.16). In contrast to the previous
The median in both groups is close to maximum score findings, the 1e-PTCA respondents scored slightly worse
of 36 (32.0 in re-PTCA vs. 33.0). A slightly worse on feelings of disability, than the re-PTCA respondents.
median score (Ps0.30) is seen in the 1e-PTCA group Between a third and almost half of the respondents
when measuring despondency with the HPPQ. The last scored above the cut-off point ()33). A significant
sub-scale of the HPPQ is that of social inhibition. difference (P-0.05) is seen between the groups in
Median scores between the groups are the same (11.0). patients that scored above the cut-off point in the sub-
None of the above mentioned differences are statistically scale despondency (HPPQ): 31% in the re-PTCA group
significant. compared to 13% in the 1e-PTCA group. When broken
The median VAS score is clearly higher in the group down per gender, it is clear that it is the male population
of respondents undergoing a re-PTCA (4.0) than in the that causes this significant difference (7% vs. 29%). On
other group (2.6), indicating higher anxiety levels in the most of the sub-scales, females scored less favourably
re-PTCA group. However, this is not a statistically than males.
significant difference (Ps0.30). As the literature does not provide a clinical implica-
The data obtained with the HADS and HPPQ also tion cut-off point in analysing the VAS, no specific
were analysed for clinical implications using the estab- value was used to differentiate between patients who
lished cut-off points for these scales. As shown in Table felt anxious and those who did not. Like in all previous
3 a greater percentage of the re-PTCA patients report at sub-scales, females felt more anxious than males.
least borderline anxiety (43% compared to 26%, Ps In addition to the questionnaires, interviews were held
0.11). The percentage of females with at least borderline with 5 patients who were admitted for a re-PTCA. The
anxiety is greater than the percentage of males in both following themes were identified: recurrent symptoms,
the 1e-PTCA and re-PTCA group. On well-being, a information, experience and future prospects. With
greater percentage of the respondents scored below the respect to recurrent symptoms, the respondents had

Table 3
Differences in outcomes within the group all patients, males and females, in percentages of patients that score worse then the predefined cut-off
point, including gender differences

All patients Male gender Female gender


e e
1 -PTCA re-PTCA P-value 1 -PTCA re-PTCA P-value 1e-PTCA re-PTCA P-value
ns46a ns40a ns30a ns31 ns16 ns9a
Anxietyb (score 08) 26% 43% 0.11 30% 31% 0.30 31% 67% 0.09
Depressionb (score 08) 15% 28% 0.30 10% 26% 0.11 25% 33% 0.67
Well-beingc (score -14) 18% 23% 0.16 17% 23% 0.61 19% 25% 1.0
Disabilityc (score )33) 47% 36% 0.32 48% 32% 0.21 44% 50% 0.77
Despondencyc (score )21) 13% 31% 0.05 7% 29% 0.03 25% 38% 0.65
Social inhibitionc (score )14) 27% 23% 0.71 17% 16% 0.91 44% 50% 1.0
VAS median 2.6 4.0 0.30 2.2 2.6 0.41 3.3 5.9 0.25
a
HPPQ analysis is based on 84 questionnaires because two respondents, one male (1e -PTCA) and one female (re-PTCA), did not entirely
complete the questionnaire.
b
HADS.
c
HPPQ.

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M.J. Lenzen et al. / European Journal of Cardiovascular Nursing 1 (2002) 195201 199

concluded, prior to the diagnosis and recommendation significant difference can be associated with a clinically
of the cardiologist that a repeat intervention was neces- relevant indication, as was seen in this study. A clear
sary. It is noteworthy that the respondents did not link trend is seen in all psychological measures of anxiety
these symptoms to a failure of the previous treatment and well-being indicative of a less favourable state in
but rather to the progression of their disease. The the repeat group compared to the first-time group. In
respondents had different views on the need for infor- the literature, poor scores on psychological question-
mation prior to the repeated procedure. Some continued naires are always associated with slower recovery w4x,
accumulating information. Others, however, felt they did more post-operative complications w8x and the occur-
not need any information, as one explained by saying: rence of cardiac ischemia and ventricular rhythm disor-
I know what it is all about. It was regarded senseless ders w29x as well as a higher mortality rate w26x in
to receive information they already knew. Another aspect patients with heart disease.
was the timing of information. Some patients experi- The fact that re-PTCA patients score less favourably
enced negative effects when information was provided may not only be attributed to their previous experience
too soon whereas other patients experienced negative with this procedure but also to the period following the
effects when information was provided too late. Descrip- procedure. Analysis of interviews with 5 patients in the
tions of both procedural and sensory information were re-PTCA group reveals that they are keenly aware of
seen in the interviews. The element that was considered the fact that the symptoms could return. The previous
most important was procedural information, as one procedure was not able to prevent the recurrence of
patient said: make clear to me beforehand what is going symptoms. This underlines the importance of future
on. The third theme recognized in the interviews was expectations.
labelled experience. The experience with the fifth The less favourable scores may also be related to
procedure played a role in how patients viewed a repeat recurrent feelings of disability, as re-PTCA patients
intervention. For example the first-time you think, experienced again limitations in their daily activities due
should I do it or notnow I dont have to think about to anginal symptoms. In contrast, when comparing the
it. As none of the 5 respondents had complications results of the present study with the outcomes of HPPQ
after their previous procedure, no link was established one year after a PTCA w30x, which are considerably
between complications and their influence on how better on well-being and feelings of disability. Other
patients prepared themselves for the repeat intervention. explanations could be the gravity of symptoms (only
The last theme considered future prospects. The respon- 13% of the respondents in Domburgs study had symp-
dents indicated a positive view of their future. They toms, compared to all in the present study) and the fact
looked forward to a period once again without any that they are not facing an intervention soon, which is
symptoms although they were aware of the fact that the considered a stressful fact w8,13,24x.
symptoms could return: but once its finishedyou As mentioned in Section 1, the self-regulation theory
really are your old self again, and: I cant expect the proposed by Leventhal and Johnson w7x was used as the
doctor to promise that Ill be fine for the next 5 years. theoretical framework of this study. This theory places
great importance on procedural and sensory information
4. Discussion w3,5,9x. In the hospital where this study took place,
existing protocols specify the delivery of this type of
This is the first study that attempts to ascertain information. Subsequently, it was assumed that both
whether patients undergoing a repeat PTCA benefit from procedural and sensory information was given to the
the same preparatory information as first-time PTCA respondents. Sensory information leads to the formation
patients. In order to determine if different preparation is of a mental image of the procedure, which has three
indicated, anxiety and well-being were compared in effects: detachment from emotional memories, recogni-
patients with a first-time and repeat PTCA. A trend is tion and habituation. These effects are believed to reduce
seen towards a worse condition in the re-PTCA group negative feelings, resulting in less anxious patients
with respect to anxiety and well-being. The only statis- w13,30x. The interviews show that some respondents
tically significant difference is seen in patients who possess accurate procedural and sensory information.
scored above the clinical implication cut-off point of the However, it is questionable if this type of information
HPPQ sub-scale despondency, which measures emotion- is equally effective for both groups of patients. Despite
al stress. This study also reveals a clear difference the repetition of procedural and sensory information,
between genders. Females score less favourably than patients in the re-PTCA group are still more anxious
males on all measures. Moerman et al. w18x also found and exhibit a lower sense of well-being than patients
that females scored higher then males on the anxiety undergoing their first PTCA. The respondents who were
scale when facing a repeat (surgical) intervention. interviewed indicate that they know what they are
The absence of significant differences, however, does facing. It could be concluded that these patients, with
not mean that the results are not important w25x. A non- their knowledge (experience), exhibited recognition and

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200 M.J. Lenzen et al. / European Journal of Cardiovascular Nursing 1 (2002) 195201

habituation, two of the above-mentioned three effects. the practicalities associated with conducting the study.
The third effect, detachment from emotional (negative) Another limiting factor is the assumption that all patients
memories, is related to a previous medical procedure were prepared in more or less the same way. The fact
and is the topic of discussion. This detachment is based that a hospital protocol specifies the provision of pre-
on the differences between a previous procedure and the paratory information does not mean that all patients
following procedure w13x. Patients undergoing a repeat received the same information. The last possible limi-
intervention will often receive the same information that tation concerns the instruments. The simple fact that
they received the first-time. The question is: how does patients had little trouble completing the questionnaires
this recall of procedural and sensory information affect and that these questionnaires have been judged to be
the emotional state of patients before the repeat proce- valid and reliable in other studies are not enough to
dure? The possibility that repeat information may awak- guarantee that the questionnaires are equally sensitive
en (negative) emotional memories instead of help the for the purpose and questions of this study. The HPPQ
patient to forget them cannot be ruled out. These with its three possible responses (correcty?yincorrect)
findings support the need for further investigation con- might not have been sensitive enough to demonstrate
cerning how to prepare patients for a repeat intervention. clear differences in this study, as it might be very
For example, should these patients be given the change tempting to check ?. In contrast, the HADS instrument
to ask their own questions? This would facilitate the offers four possible responses, which encourages patients
provision of information based on a dialogue with the to make a choice. The previously described factors need
patient instead of rigid adherence to standard informa- to be addressed in future investigations.
tion. Maybe there is a greater need for emotional
support than for information concerning a procedure 5. Conclusion
with which they are already familiar. Furthermore,
coaching may be appropriate in this context. Coaching However, there are no statistically significant differ-
is a continuous process of supporting, stimulating and ences between the two groups, a trend is seen towards
advising patients to help them meet the goals, that they a worse condition in the re-PTCA group with respect to
have helped to set. These questions can best be explored anxiety and well-being. It cannot be concluded however,
with a qualitative descriptive investigation. that undergoing a repeat intervention (re-PTCA) causes
In addition to sensory information, the theory of more anxiety. The less favourable score of the re-PTCA
Leventhal and Johnson w7x focuses on the activation of patients may be attributed to the return of the symptoms
the coping mechanism and on coping instructions. The and new feelings of disability, instead of the procedure
interviews demonstrate that respondents with recurring itself. Besides the above-mentioned difference between
symptoms already consider the necessity of a repeat the two groups, both groups of patients show a clear
intervention. However, this might have activated their discrepancy between desired and actual ability. The
coping mechanism in an early stage (i.e. thinking that a interviews indicate that these patients know what they
repeat PTCA is needed), these patients did not prove to are facing and underline the importance of a positive
be less anxious. Also the question arises, is self-regula- view of the future. These patients are aware that symp-
tion theory w7x the appropriate approach to use with toms can return, even though the results of the previous
patients undergoing a repeat procedure? The theory does and current treatment can be considered to be successful.
not explain how to deal with patients from the moment In other words, they know that they are not cured.
their symptoms return, how to deal with the fact that Finally, it should be noted that research does not only
the information is known to the patients or how to deal help explain the rationale behind certain actions, such
with the patients after the procedure. The interviews as giving preparatory information in the context of the
made it clear that patients have different needs with theory by Leventhal and Johnson w7x. Research also
respect to seeking out information. This is consistent gives insight into which actions lead to the desired effect
with the reviewed literature, which refers frequently to and which do not. In this study, one of the desired
the coping style of the patient w13,30x. The central issue effects of preparatory information, namely reduction in
is rather than the type of information that is provided anxiety is less pronounced in the re-PTCA group of
the way in which a person copes with a threatening patients. Clearly, additional or different actions are
situation, regardless of previous interventions. needed to reduce anxiety in patients undergoing a repeat
intervention. Further research is required.
4.1. Limitations
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