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Introduction:
Chondrosarcoma is one of the commonest malignant, slow-growing,
cartilaginous tumor originating in bone
usually present for many months before being discovered.
Incidence:
The highest incidence is in the fourth and fifth decades and
Men are affected more often than women.
C/F
Patients may complain of a dull ache or a gradually enlarging lump.
Medullary lesions may present as a pathological fracture.
Site:
almost 50 % appear in the metaphysis of the long bones, mostly in the lower
limbs.
The next most common sites are the pelvis and the ribs.
Rarely in the bones of the hands and feet
Staging
If a chondrosarcoma is suspected, full staging procedures should be
employed. CT scans and MRI must be carried out before performing a biopsy.
Pathology
A biopsy is essential to confirm the diagnosis. However, low-grade
chondrosarcoma may show histological features no different from those of an
aggressive benign cartilaginous lesion. High-grade tumours are more cellular,
and there may be obvious abnormal features of the cells, such as plumpness,
hyperchromasia and mitoses.
Treatment
Since most chondrosarcomas are slow-growing and
metastasize late, they present the ideal case for wide
excision and prosthetic replacement, provided it is
certain that the lesion can be completely removed
without exposing the tumour and without causing an
unacceptable loss of function; in that case amputation
may be preferable. In some cases isolated pulmonary
metastases can be resected. The tumour does not
respond to either radiotherapy or chemotherapy.
Prognosis is determined largely by the cellular
grade and the resection margin. There is a tendency
for these tumours to recur late and the patient should
therefore be followed up for 10 years or longer.