DEXTRIN CROSSLINKED WITH POLY(HEMA): AN EFFICIENT HYDROGEL FOR CIPROFLOXACIN

HYDROCHLORIDE DELIVERY

Dipankar Das1, 2, 3 and Insup Noh2, 3*

1
Indian Institute of Technology (Indian School of Mines), Dhanbad, India.

2
Department of Chemical and Biomolecular Engineering, 3Convergence Institute of Biomedical Engineering and Biomaterials, Seoul
National University of Science and Technology, Seoul, Korea, insup@seoultech.ac.kr

A chemically crosslinked hydrogel (c-Dxt/pHEMA) based on dextrin grafted with poly(2-hydroxyethyl methacrylate)
by embedding N,N′-methylene bisacrylamide (MBA) as cross linker, into a polymeric network in the presence of
potassium persulphate (KPS) initiator has been developed for an oral route administration for ciprofloxacin
hydrochloride delivery. Various grades of hydrogels (c-Dxt/pHEMA) have been synthesized by altering the
reaction parameters and the best one optimized. The developed hydrogel has been characterized using
FTIR, 13C NMR and elemental analysis. , XRD study, SEM analysis, TGA analysis, swelling study and cell
viability study. The equilibrium swelling ratio of the hydrogels has been recorded in different media and found to
be at a maximum at pH 7.4. A cell viability study indicates that the hydrogel is non-cytotoxic in nature. The drug
delivery results demonstrate that Dxt-g-p(HEMA) delivers ornidazole successfully in the colonic region in a
controlled way and is a good candidate for an orally administered drug delivery system. The release mechanism
and kinetics of ornidazole from various hydrogels have been determined using different linear and nonlinear
mathematical models, which confirm that ornidazole release from hydrogel follows first order kinetics and a non-
Fickian diffusion mechanism.

Various characteristics such as FTIR spectra, XRD analyses, UV–VIS–NIR spectra, FESEM and E-SEM
analyses, rheological characteristics, gel kinetics, deswelling characteristics as well as
biodegradation study of the hydrogel have been carried out. FTIR, XRD along with solid state UV–

VIS–NIR analyses explain the good compatibility between the drug and the hydrogel matrix. The

in vitro release study demonstrates that c-Dxt/pHEMA releases ciprofloxacin in a sustained way
(33.75% of drug has been released in 18 h) and is expected to be a promising matrix for

ciprofloxacin carrier. The release kinetics and mechanism suggest that drug release follows first
order kinetics and non-Fickian diffusion mechanism. Finally, the hydrogel shows excellent physical

stability as carrier for ciprofloxacin up to 3 months