Food Therapy: Eggplant In Reduced Risk of Acute

Inflammation and Treatment of Chronic Inflammatory

Diseases

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Eggplant may be used as a therapeutic and positive anti inflammatory

functional food without alernating the immune activity in the acute phase of
infection, some scientists opinionated.

Eggplant with deeply purple colcor, is a species of S. melongena, belongs to the

family Solanaceae cultivated in southern and eastern Asia since prehistory, and
native to India.

Inflammation is a natural expression by immune system in induction of while

blood cells for protection our body against infection caused by foreign
invasion.

In the differentiation of water extract of Solanum melongena L. (Solanaceae)

effect in induction of antioxidant, analgesic, hypolipidemic and antiallergic
activity in mice induced by injection of trypsin or trans-cinnamoyl-LIGRLO-
NH(2) (tc-NH(2)) into the hindpaw scientists found that oral administration of
the extract at doses of 5, 10, and 100 mg/kg displayed a strong effect in
inhibition of both paw edema and vascular permeability.

Further analysis also showed that the highest dose injection of 10 mg/kg
expressed a greatest activity in compared to the others in significantly inhibited
PAR2 agonist-induced myeloperoxidase (MPO) activity in stimulated immune
function activated pro inflammatory cytokines and tumor necrosis factor
(TNF)-alpha expression to precipitate inflammation in response to the acute
phase of infection.

After taking into account of other confounders, Dr. Umamageswari MS

suggested that water extract of the S. melongena (SMWE) inhibits PAR2
agonist-induced mouse paw edema, through its anti inflammatory expression.

According to the investigated the inflammatory activities of aqueous extract of

leaves of Solanum melongena Linn in arrageenan induced paw oedema, in
compared to standard medicne aspirin, oral application of Solanum melongena
L. in different doses of 100mg/kg, 200mg/kg, 400mg/kg at 1(st) h, 3(rd) h, and
5(th) after injection revealed a significant effect in reduced inflammation
linearly induced by carrageenan toxicity in dose dependent manner.

Additional differentiation, also suggested that the doses of 200mg/kg and 400
mg/kg of aqueous extract of S. melongena L showed the percentage of
inhibition of 42.62% which is less than the standard drug aspirin which showed
64.5% inhibition.

In free radical perspective, the investigation of 4 our new lignanamides,

melongenamides A-D (1-4), together with six known ones (5-10) isolated from
the roots of Solanum melongena L. also demonstrated a significant activity in
inhibitions of inflammatory effect caused by free radical species nitric oxide
production in lipopolysaccharide-induced RAW 264.7 macrophages through
their antioxidant effect.

Interestingly, the study also found out that not all compound extracted from the
roots expressed the same levels of antioxidant properties in reduced
inflammatory induced by ROS. In compared to other compounds, compound 1
exerted antioxidant effect without inhibited free radical nitric oxide production.

The findings suggested that eggplant may be used as function food in reduced
risk of inflammation in acute infection and as a adjunct therapy in combination
with standard treatment of chronic inflammatory diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published on line, including world wide health, ezine
articles, article base, healthblogs, selfgrowth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced
inflammation by Han SW1, Tae J, Kim JA, Kim DK, Seo GS, Yun KJ, Choi
SC, Kim TH, Nah YH, Lee YM.(PubMed)
(2) Evaluation of anti-inflammatory activity of aqueous extract of leaves of
solanum melongena linn. In experimental animals by Umamageswari MS1,
Maniyar YA2.(PubMed)
(3) Anti-inflammatory lignanamides from the roots of Solanum melongena L
by Sun J1, Gu YF1, Su XQ1, Li MM1, Huo HX1, Zhang J1, Zeng KW2, Zhang
Q3, Zhao YF3, Li J4, Tu PF5.(PubMed)