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INTEGRAL CELL ADHESION MOLECULES (ICAMs)

- 16 or ore known
- Essential role in mutual recognition and aggregation of cells of same type during embryonic dev. And in epithelial cohesion and
attachment to substrate in postnatal life how recognition takes place. Very little is known.

PRINCIPAL CLASS OF ICAMs ARE THE “CADHERINS” FUNCTIONS:

1. Are prerequisite for development of other cohesional mechanisms, w/out these cadherins, formation of junctional
complexes(desmosomes) cannot occur
-they are integral proteins.
2. theyare important in morphogenesis and differentiation.

Ex.

E- cadherin: epithelial cell belt desmosomes

N- Cadherin: nerve, muscle, lens of eyes

P- cadherin: placenta and epidermal cells