GASTROINTESTINAL AND HEPATOBILIARY SYSTEM

ANTACIDS, ANTIREFLUX AGENTS AND ANTIULCERANTS

ADVERSE DRUG
BRAND NAME GENERIC NAME USE CONTRAINDICATION MANUFACTURER
REACTIONS
Treatment of symptoms of
Na alginate GERD (acid regurgitation,
nausea, constipation, Nausea, constipation,
Gaviscon Na bicarbonate heartburn, and indigestion Reckitt Benckiser
diarrhea, headache diarrhea, headache
Ca carbonate due to reflux of stomach
content
Treatment of duodenal Hypersensitivity
Constipation, dry mouth,
Iselpin Sucralfate ulcer, gastric ulcer and Patients undergoing Pfizer
nausea
chronic gastritis dialysis
Symptomatic relief of
hyperacidity associated
with peptic ulcer,
gastritis, esophagitis, and
dyspepsia
Antiflatulent to alleviate Constipation, black stools,
Aluminum hydroxide the symptoms of pain during urination Appendicitis
Kremil-S Magnesium hydroxide gassiness, including Stomach or abdominal Blockage of intestines UniLab
Simeticone postoperative gas pain, pain Breastfeeding
associated with Vomiting
hyperacidity
Adjunct to H2-blockers or
proton pump inhibitors for
the rapid relied of ulcer
symptoms
Duodenal ulcer
Prevention of relapse of
Contraindicated in patient
duodenal ulcer
with Clostridium difficile
Gastric ulcer and reflux Headache, diarrhea,
infection
esophagitis constipation, abdominal
Losec Omeprazole Inadequate Vitamin B12 AstraZeneca
Poorly responsive gastric pain, nausea, vomiting,
Low amount of Magnesium
ulcer flatulence
in the blood
Severe reflux esophagitis
Liver problems
Prevention of relapse of
gastric ulcer

1
 NSAID-associated duodenal
and gastric ulcers or
gastroduodenal erosions
H. pylori-associated PUD
Dyspepsia
Symptomatic GERD
Acid aspiration prophylaxis
Zollinger-Allison syndrome
Al(OH)3 Symptomatic relief of Severe debilitation,
Maalox Rarely, GI disturbances sanofi-aventis
Mg(OH)2 hyperacidity kidney failure
Hypersensitivity. State of
cachexia (general wasting
Gastritis and duodenitis
Al(OH)3 away of the body),
accompanied by
Maalox Plus Mg(OH)2 GI disturbances (rare) porphyria sanofi-aventis
flatulence, post-op gas
Simeticone Severe forms of kidney
pain
failures
Children
Treatment of gastric
ulcers, gastric mucosal Rarely hypersensitivity Discontinue if markedly
lesions (erosion, bleeding, reactions increase transaminase,
redness and edema) in GI disturbances fever, rash and
Mucosta Rebamipide acute gastritis and Menstrual disorder, hypersensitivity reactions Otsuka
exacerbation of chronic dizziness, edema and develop
gastritis foreign body feeling in the Pregnancy and lactation
Prevention of NSAID- pharynx Elderly
induced hypersentivity
Headache, abdominal Hypersensitivity to
Erosive reflux esophagitis
pain, diarrhea, flatulence, esomeprazole substituted
Nexium Esomeprazole Symptomatic treatment of AstraZeneca
nausea, vomiting, benzimidazoles
GERD
constipation Lactation
Active duodenal ulcer and
GERD with erosive
Constipation, diarrhea,
esophagitis
flatulence, nausea, Chronic liver disease
Symptomatic GERD
vomiting and acid (including in history)
Omepron Omeprazole without esophageal lesions Westmont
regulation Hypersensitivity to
Maintenance of healing of
Abdominal pain, asthenia, Omepron
erosive esophagitis
headache, dizziness, rash
Pathological
hypersecretory conditions

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 H. pylori eradication in
PUD
Mild reflux disease and
Pantoloc Pantoprazole
associated symptoms
Abdominal pain, asthenia,
Active duodenal ulcer,
active benign gastric
Pariet Rabeprazole Na ulcer, anastomatic ulcer,
symptomatic erosive or
ulcerative GERD
Conditions including
aspiration syndromes,
Peptisolv Omeprazole dyspepsia, GERD, peptic
abnormalities, hematuria,
ulcer and Zollinger-Ellison
syndrome
Duodenal ulcer
Gastric and stomal ulcer, jaundice, toxic epidermal
Prevacid Lansoprazole
reflux esophagitis,
Zollinger-Ellison syndrome
state, insomnia, dizziness,
Hypersensitivity
In combination treatment
Headache for H. pylori eradication in
Upper abdominal pain, patients with moderate to
Takeda
diarrhea, constipation, severe hepatic or renal
flatulence impairment
Concomitant use with
atazanavir
Headache, diarrhea,
nausea
flatulence, rash and dry
mouth
Hypersentivity to
Infection
rabeprazole Na and
Insomnia
substituted Eisai
Dizziness
benzimidazoles
Cough, pharyngitis,
Pregnancy and lactation
rhinitis
Vomiting, constipation
Nonspecific pain, back
pain
Flu-like syndrome
Skin reactions,
hematologic
Chronic hepatic disease Unison
proteinuria and UTI
Pancytopenia,
agranulocytosis,
granulocytopenia, severe
hepatic dysfunction with Hypersensitivity
Patients receiving
Takeda
necrolysis atazanavir sulfate
Headache, sleepiness, Lactation
numbness, depressed
tremor
3
 Duodenitis, duodenal
erosions, duodenal ulcers,
gastritis,, gastric erosions,
gastric ulcers,
symptomatic GERD with or
Protonix Omeprazole
without erosive
esophagitis, Zollinger-
Ellison syndrome and in
the eradication of H.
pylori
Active duodenal ulcer,
benign gastric ulcer,
Rabesta Rabeprazole Na Zollinger-Ellison syndrome
and ulcerative or erosive
GERD
Duodenal ulcer, gastric
ulcer, H. pylori-associated
PUD, reflux esophagitis
and Zollinger-Ellison
Risek Omeprazole syndrome GERD,
maintenance of healed
erosive esophagitis,
NSAID-associated ulcer,
acid aspiration
PUD including stress
ulceration, GERD,
persistent dyspepsia,
pathological
Ulcedrug Ranitidine HCl
hypersecretory state and
in patient at risk of acid
aspiration during general
anesth or childbirth
Used in conditions where
inhibition of gastric acid
secretion may be
Wilom Omeprazole beneficial, including
aspiration syndromes,
dyspepsia, GERD, PUD and
Zollinger-Ellison syndrome
Contraindicated in
patients with known
Headache, diarrhea, hypersensitivity to any
constipation, abdominal component of the
Hizon/Carels
pain, nausea, vomiting, formulation or any
dizziness, rash substituted
benzimidazoles
Lactation
Diarrhea, nausea,
Hypersensitivity to
headache, vomiting,
rabeprazole and Stallion Labs
abdominal pain,
substituted benzimidazole
flatulence
Rash, vertigo, headache,
diarrhea, constipation, Hypersensitivity to
abdominal pain, substituted Getz Pharma
nausea/vomiting and benzimidazoles
flatulence
Transient and reversible
changes in liver function
test Hypersensitivity Medhaus
Headache, dizziness, skin
rash
Headache, diarrhea and
skin rashes
Pruritus, dizziness,
fatigue, constipation,
Pregnancy Hizon
nausea and vomiting
Abdominal pain, arthralgia
and myalgia, urticarial
and dry mouth
4
 Headache, weakness
Famotidine injection is (asthenia), fatigue,
Hypersensitivity to
indicated for some paresthesia, tonic-clonic
famotidine, other H2
hospitalized patients with (grand-mal) seizure,
H2 Bloc Famotidine receptor antagonists or Myung In Pharma. Co
pathological irritability (fussing),
any component of the
hypersecretory conditions insomnia, drowsiness and
product.
or intractable ulcers. reversible psychic
disturbances
GIT REGULATORS, ANTIFLATULENTS AND ANTI-INFLAMMATORIES
Increased prolactin levels Gi hemorrhage,
GI disorders mechanical obstruction or
Dyspeptic symptom
Transient intestinal perforation
complex associated with
Motilium Domperidone cramps In patients with Johnson & Johnson
delayed gastric emptying,
Galactorrhea prolactinoma
GERD, esophagitis
Gynecomastia Known intolerance to the
Amenorrhea drug
Post-op vomiting, drug-
induced nausea and
vomiting, vomiting due to
Dystonic reactions GI hemorrhage,
radiation and anti-cancer
Toridon Domperidone Galactorrhea or obstruction, perforation or Torrent
drugs and acute vomiting
gynecomastia immediately after surgery
due to fever, gastritis,
pancreatitis, uremia and
hepatitis
Dyspepsia syndrome
Intolerance
accompanied by delayed
GI bleeding, mechanical
gastric emptying,
Rash and urticaria obstruction or perforation
Vometa Domperidone esophageal reflux and Gracio Med
Hyperprolactinemia Prolactinoma and tumor
esophagitis
hypohyloma
Nausea and vomiting due
Pregnancy and lactation
to various causes
ANTISPASMODICS
Acute GI, biliary and Myasthenia gravis and
genitourinary spasm megacolon
Xerostomia, tachycardia,
including biliary and renal Should not be used in
urinary retention, allergic
Buscopan Hyoscine-N-butylbromide colic patients who have prior Boehringer Ingelheim
and skin reactions, rarely
Parenterally also as an aid sensitivity to hyoscine-N-
dyspnea
in diagnostic and butylbromide or any
therapeutic procedures component of Buscopan

5
 Paroxysmal pain in the
Myasthenia gravis,
diseases of the stomach or Pancytopenia,
megacolon, severe
Hyoscine-N-butylbromide intestine, spastic pain and agranulocytosis,
Buscopan Plus hepatocellular Boehringer Ingelheim
Paracetamol functional disorders in the thrombocytopenia,
insufficiency, rare
biliary and urinary tracts leukopenia
hereditary conditions
and female genital organs
GI spasm and
hypermotility,
pylorospasm in infant,
post-op vomiting, spastic
constipation, biliary CNS effects Impaired metabolic liver
Gastride Hyoscine-N-butylbromide Standard Chem
dyskinesia and spasm of Increase in pulse rate or kidney function
the urinary tract, delayed
relaxation of the lower
uterine segment,
dysmenorrhea
Gastric and duodenal
ulcers, GI spasm and
hypermotility,
Glaucoma, prostatic
pylorospasm in infants, Slight increase in pulse
hypertrophy with urine
post-op vomiting, spastic rate during IV
Xspas Hyoscine butylbromide retention, mechanical Neon
constipation, biliary administration
stenosis in GIT,
dyskinesia and spasm of Urticaria
tachycardia, megacolon
the urinary tract, delayed
relaxation of lower
uterine segment
ANTIDIARRHEALS
Constipation, nausea, Constipation
Symptomatic control of
vomiting, tiredness, Acute ulcerative colitis,
Diatabs Loperamide HCl acute and chronic diarrhea United Lab
drowsiness or dizziness, pseudomembranous
Ileostomy
dry mouth colitis, acute dysentery
Treatment of acute
diarrhea with duration of Acute diarrhea ≤14 days
≤14 days due to duration due to infections,
Erceflora Bacillus clausii infections, drugs or drugs or poisons Hypersensitivity sanofi-aventis
poisons or for chronic or Chronic or persistent
persistent diarrhea with diarrhea >14 days duration
duration of >14 days

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As supplement to
rehydration, treatment of
acute diarrhea presumed
Ercefuryl Nifuroxazide
to be of bacterial origin in
the absence of suspected
invasive phenomena
Symptomatic treatment of
Hidrasec Racecadotril
acute diarrhea in adults
Acute diarrhea, chronic
Imodium Loperamide HCl
diarrhea
Adjunct in the
symptomatic management
of acute and chronic
Lomotil Loperamide HCl diarrhea and management
of colostomies or
ileostomies to reduce vol
of discharge
LAXATIVES, PURGATIVES
Constipation
Prep for radiography
Antepartum & postpartum
care
Dulcolax Bisacodyl
Prep for sigmoidoscopy or
proctoscopy
Colonoscopy, hemorrhoids
and anal fissures
Hypersensitivity to
nitrofuran derivatives
Premature and infants <2
Allergic reactions, skin
yr
rash, urticarial, Quincke’s
Fructose intolerance, sanofi-aventis
edema or anaphylactic
glucose-galactose
shock
malabsorption syndrome
or sucrose-isomalitase
deficiency
Hypersensitivity
Headache Rare hereditary problems Abbott
of galactose intolerance
Hypersensitivity
Hypersensitivity reactions,
Acute ulcerative colitis or
constipation and/or
pseudomembranous colitis
abdominal distention
associated with broad-
Dry mouth, nausea,
spectrum antibiotics, Johnson & Johnson
vomiting, abdominal pain
primary therapy in acute
and discomfort, tiredness,
dysentery and when
drowsiness, dizziness and
inhibition of peristalsis is
urinary retention (rare)
to be avoided
Patients with intestinal
obstruction, abdominal
Constipation, colic,
distention, constipation or
abdominal distress,
intestinal atoria, acute
nausea, vomiting, fatigue, Johnson & Johnson
ulcerative colitis,
somnolence, dizziness, dry
pseudomembranous colitis
mouth, and mild skin rash
associated with broad-
spectrum antibiotics
Ileus, intestinal
obstruction, acute surgical
abdominal conditions
Rarely, abdominal
Severe dehydration Boehringer Ingelheim
discomfort and diarrhea
Appendicitis and acute
inflammatory bowel
diseases
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 All conditions which
require defecation to be
facilitated
Ileus, intestinal
Constipation and Abdominal discomfort, obstruction, acute surgical
conditions which require cramps and pain abdominal conditions
Dulcolax SP Na picosulfate Boehringer Ingelheim
defecation to be Diarrhea Severe dehydration
facilitated Allergic reaction Continuous and prolonged
use
Constipation Hypersensitivity
Hepatic encephalopathy Diarrhea, flatulence, Galactosemia
Duphalac Lactulose Treatment and prevention abdominal pain, nausea, GI obstruction, digestive Abbott
of hepatic coma or vomiting perforation or risk of
precoma digestive perforation
Abdominal discomfort
associated with flatulence
or cramps
Constipation
Prolonged use or large Low galactose diet and
Lilac Lactulose Treatment of hepatic Getz Pharma
doses may result in intestinal obstruction
encephalopathy
diarrhea with excessive
loss of water and
electrolytes
Relief of functional
constipation through
peristaltic stimulation
Standardized senna
Senokot Relief and control of Abdominal pain Acute surgical abdomen Mundipharma
concentrate
constipation in the
elderly, during pregnancy
and puerperium
DIGESTIVES
Treatment of conditions
GI disorders, abdominal
Creon Pancreatin associated with pancreatic Hypersensitivity Abbott
pain, diarrhea
exocrine insufficiency
CHOLAGOGUES, CHOLELITHOLYTICS AND HEPATIC PROTECTORS
Nutritional support in the
Occasionally, stomach Hypersensitivity to soya
management of damaged
Essentiale Forte Phospholipids complaints, soft stool, bean prep sanofi-aventis
liver due to chronic liver
diarrhea Children <12 yr
disease, liver cirrhosis,

8
 fatty liver and intoxication
by hepatotoxic substances
Treatment of acute and
Carnitine orotate
chronic hepatitis, fatty
Pyridoxine HCl
liver, liver cirrhosis, liver Occasionally, stomach
Cyanocobalamin Hypersensitivity to soya
Godex intoxication by drug or complaints, soft stool, Mergers Drugfil
17 amino acids bean preparation
chemical substances, diarrhea
Adenine HCl
mitochondrial
Riboflavin
dysfunctions
Silymarin
Thiamine HCl Indigestion Diarrhea, discontinue use
Aid in the treatment of
Riboflavin Loose motion if adverse symptoms occur
various liver disorders and
Liver Gold-F Nicotinamide Bloating and not improved within 1 Daewoong Pharma
to prevent hepatotoxicity
Ca pantothenate Urge to vomit month of treatment
associated with poisoning
Pyridoxine HCl Stomach pain Pregnancy
Cyanocobalamin
Treatment of liver
Phosphatidyl choline
diseases of any origin
Nicotinamide At higher doses, may
Hepatitis, cirrhosis, toxic
dl-α tocopheryl acetate cause reduced appetite,
metabolic liver diseases,
Livolin Forte Vit B1 nausea, abdominal Hypersensitivity Mega Lifesciences
intoxication, alcoholic
Vit B2 bloating, GI pain and
fatty liver, pre- and post-
Vit B6 diarrhea
op care in
Vit B12
liver/gallbladder surgery
Hypersensitivity to
Carnitine orotate Treatment of acute and
Paresthesia Mitodex Powder
Carnitine HCl chronic hepatitis, fatty
Somnolence Atrophic gastritis
17 amino acids liver, hepatic cirrhosis,
Mitodex Low serum folic acid Hypersensitivity to Mergers Drugfil
Pyridoxine HCl and intoxication by drug
levels adenosine
Cyanocobalamin or chemical substance
Pulmonary edema Leber’s hereditary optic
Adenosine Mitochondrial dysfunctions
atrophy
Biliary disorders, toxic and
Pinene chronic inflammatory
Camphene conditions of the liver,
Cineol pre-op and post-op
Soreness of mouth and
Rowachol Menthone treatment of the None known Rowa/New Marketlink
buccal ulceration
Menthol hepatobiliary system
Borneol Adjunct in the treatment
Olive oil of diabetic condition
Dyspepsia
9
 Hypersensitivity to bile
acids
Cholestatic liver disease,
Acute inflammation of the
cholesterol gallstone Porridge-like stools
Ursofalk Ursodeoxycholic acid gallbladder or biliary tract Falk/A. Menarini
dissolution, biliary reflux Pasty stools or diarrhea
Occlusion of the biliary
gastritis
tract
Pregnancy and lactation
URINARY DISORDER
Pinene
Camphene
Urolithiasis,
Cineol
nephrolithiasis, cystitis, Slight and temporary
Rowatinex Fenchone 1st trimester of pregnancy Rowa/New Marketlink
renal colic, UTI, post-op stomach upset
Borneol
prophylaxis of calculi
Anethol
Olive oil
ANORECTAL PREPARATIONS
Organic and functional
chronic venous diseases of Diarrhea, dyspepsia,
the lower limbs nausea, vomiting
Micronized purified Heavy legs, pain, Uncommonly, colitis
Daflon Hypersensitivity Servier
flavonoid fraction nocturnal cramps Rarely dizziness,
Hemorrhoidal disease, headache, malaise, rash,
acute hemorrhoidal pruritus, urticaria
disease and attacks
External and internal
hemorrhoids associated
Mild local discomfort Hypersensitivity to soya or
Policresulen with inflammatory
Faktu Very rarely, anaphylactic peanut Takeda
Cinchocaine symptoms or superficial
reactions 1st trimester of pregnancy
bleeding, anal fissures and
rhagades
Internal and external
Framycetin sulfate hemorrhoids, prophylaxis Hypersensitivity to
Skin rash or irritation due
Aesculin between attacks to hydrocortisone or
Proctosedyl to sensitivity to sanofi-aventis
Cinchocaine HCl prevent recurrences conchocaine or any of the
ingredients
Hydrocortisone Hemorrrhoidal excipients
complications
ANTIEMETICS

10
 Motion sickness Drowsiness
Nausea and vomiting of Dry mouth, fatigue,
Glaucoma, breathing
pregnancy vomiting
Bonamine Meclizine HCl problem or prostatic Taisho
Labyrinthine and Rarely, blurred vision
enlargement
vestibular disturbances Excitability, esp in
Radiation sickness children
Hypersensitivity to
Management of nausea Extrapyramidal symptoms
clomitenesol including
and vomiting associated Restlessness, drowsiness,
Clomitene Metoclopramide HCl bleeding of the stomach or LBS
with various GI disorders, dizziness, headache and
intestines and chronic
in GERD and gastric stasis bowel upsets
heart failure

11