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NAME:_______________________ C#:________________
HONOR CODE
Students are required to uphold the student Honor Code. It is the policy of the
Biology Department that academic dishonesty or complicity with the dishonest will
result in a failing grade in the course.
INSTRUCTIONS
FIRST: Clearly write your NAME, C#, FORM # and SEAT # on your scantron and
this exam paper.
PART I
Answer Part I of the exam using the scantron sheet provided. Make only one
choice per question. If you fail to use the scantron sheet to answer the questions in
Part I of this exam your answers will not be graded.
PART II
Answer Part II of the exam in the space provided on the exam question
sheet. Your handwriting must be legible or your exam will not be graded.
1
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
4. Mendel's Second Law states that the gene pairs on homologous chromosomes
assort independently at mitosis.
a) True
b) False
5. The sum rule states that the probability of either of two mutually exclusive
events occurring is the sum of their individual probabilities.
a) True
b) False
10. Crossovers are needed to maintain the intact tetrad until anaphase I of meiosis.
If crossing-over fails, first division non-disjunction occurs.
a. True
b. False
2
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
11. The number of chromosomes in the basic genomic set of an organism is known
as its __________________ set.
a) diploid
b) homologue
c) nucleosome
d) haploid
e) chromatin
14. How many different types of gametes can an individual with the genotype
AaBBccDdEeFf form?
a) 4
b) 12
c) 16
d) 64
e) 256
15. A rare dominant trait, when exhibited in men, is transmitted to half their sons
and to half their daughters. The gene for this trait is carried:
a) on the X chromosome
b) on an autosome
c) on the Y chromosome
d) in the mitochondria
e) None of the above
16. If an individual has 10 gene pairs, how many different gametes can be formed if
five of the gene pairs are homozygous and the remaining 5 gene pairs are
heterozygous?
a) 42
b) 109
c) 32
d) 1024
e) cannot be determined
3
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
17. Assuming Mendel’s Second Law is correct, what is the expected segregation ratio
for traits in a dihybrid cross?
a) 1:1
b) 3:1
c) 1:1:1:1
d) 9:3:3:1
e) None of the above.
18. A trihybrid cross is a cross between two individuals who are heterozygous for
three genes. For example: AaBbCc x AaBbCc. Assuming these three genes are
unlinked and assorting independently, what segregation ratio would be observed?
a) 9:3:3:1
b) 1:1:1:1
c) 16:9:9:3:3:1
d) 27:9:9:9:3:3:3:1
e) 12:9:3:1
19. Mendel’s law of independent assortment has its physical basis in the:
a) separation of alleles into haploid cells.
b) spindle attachment in anaphase I.
c) random arrangement of chromosomes on the metaphase plate in
meiosis I.
d) sister chromatids separating in meiosis II.
e) haploid cells forming.
22. Which of the following describes the relationship between Hfr strains and
F′ strains?
a) An Hfr strain donates DNA to an F- strain, thus converting it into an F+
strain.
b) After DNA is transferred from an Hfr to an F-, the Hfr strain becomes
an F+ strain.
c) When an Hfr strain is used for transduction, it is called an F+ strain.
d) Hfr strains can be converted into F+ strains through the liberation of
the F factor and some flanking bacterial DNA from the bacterial
chromosome.
4
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
28. In maize, two plants that are both heterozygous for the recessive alleles a and b
are crossed. What frequency of double-mutant progeny will appear if a and b are
7.2 map units apart, and both parents carry a and b in replusion (trans)?
a) 0.036
b) 0.063
c) 0.001
d) 0.005
e) 0.072
5
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
29. Out of 800 progeny of a three-point test cross there were 16 double crossovers,
whereas 80 had been expected on the basis of no interference. What is the
interference?
a) 0.10
b) 0.20
c) 0.05
d) 0.50
e) 0.80
30. From an F+ strain with markers c d e b (in that circular order), which of the
following derived Hfrs is impossible?
a) c enters first and then e
b) c enters first and then d
c) d enters first and then c
d) d enters first and then e
e) e enters first and then b
31. A certain diploid plant is 2n = 24 and all the chromosomes are small. If DNA is
extracted from plant tissue in mitotic metaphase and run on a pulsed-field
electrophoresis gel, how many DNA bands should be visible?
a) 6
b) 12
c) 24
d) 48
e) 96
6
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
35. A phenotypically normal woman is a carrier of the recessive allele that causes
albinism. What proportion of her eggs will carry the mutation that results in an
absence of melanin?
a) None
b) All
c) ¾
d) ½
e) ¼
36. The following pedigree shows the inheritance of attached earlobes (black
symbols) and unattached earlobes (open symbols). Both alternate phenotypes
are quite common in human populations.
38. A couple in Indiana are each heterozygous for the autosomal recessive allele for
phenylketonuria (PKU). They have two children. What is the probability that both
children will also be carriers?
a) 3/4
b) 1/16
c) 1/4
d) 9/16
e) 5/8
39. In a cross made with variegated Four O’Clock plants, pollen is provided from
flowers on a white sector, and ovules from a green sector. The progeny are
expected to be
a) All green
b) All white
c) All variegated
d) Some variegated, some green and some white
e) Some variegated and some white
7
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
40. Flower position, stem length, and seed shape were three characters that Mendel
studied. Each is controlled by an independently assorting gene and has dominant
and recessive expression as follows:
If a plant that is heterozygous for all three characters were allowed to self-
fertilize, what proportion of the progeny would be homozygous for terminal and
dwarf and have round seeds?
a) 1/4
b) 1/8
c) 1/32
d) 1/64
e) 3/64
8
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
9
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
42. If you had a fruit fly that was of phenotype A, what test would you make to
determine if the fly's genotype was A/A or A/a? (2 points)
43. The pedigree below was obtained for a rare kidney disease. If persons 1 and 2
marry, what is the probability that their first child will have the kidney disease?
(6 points)
1 2
10
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
44. In E. coli, four Hfr strains donate the following markers, shown in the order
donated:
Strain 1: M Z X W C
Strain 2: L A N C W
Strain 3: A L B R U
Strain 4: Z M U R B
All the Hfr strains are derived from the same F+ strain. What is the order of these
markers on the circular chromosome of the original F+? (4 points)
11
FORM 1
Dr Alex Wilson 2009 Midterm I BIL250
a) What were the genotypes of the two parental mice in the cross? (4 points)
c) If you deduced linkage, state the map unit value or values and show how they
were obtained. (4 points)
12
FORM 1