TNF -

containment of infection but can induce SHOCK

Cytokine that
triggers
local
.

soluble

travels around body

many Cells
.

2 receptors : 1 . TNFRI =

( )
2 . TNFRZ
=
found Only On
lymphocytes TIB cells

to
TNF secreted
LPS detected by TLRY in macrophage bloodstream
&
& blood clots

t
NFKB producing TNF a in tissue
.

blood vessel
d collapse
tissue
increase phagocyte & lymphocyte migration to
&
platelet adhesion
failure
W organ

phagocytosis of bacteria ,
cells drain to lymph nude