* DIC leads to the formation of small blood clots inside the blood

vessels throughout the body

* The small clots consume coagulation proteins and platelets,

 
 
  
 normal coagulation is disrupted and abnormal bleeding occurs from
    the skin, the gastrointestinal tract, the respiratory tract and surgical
wounds. The small clots also disrupt normal blood flow to organs
      * DIC can occur acutely slower, chronic basis, and may participate
      in the development of multiple organ failure, which may lead to

   
   death.
* In acutely ill and shocked with widespread hemorrhage (common
bleeding sites are mouth, nose and venipuncture sites), extensive
bruising, renal failure and gangrene.


    
 


 
   
  
    
    
 
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_ Primary hemostasis
_ Formation of a platelet plug
_ Vasculature and platelets
_ Secondary hemostatis

   $ _ Consolidation of the platelet plug by fibrin
_ cascade and inhibitors
_ Fibrinolysis
_ Cleanup
_ cascade and inhibitors

ᑠa group of physiological processes occurring soon after the

onset of infection, trauma, inflammatory processes, and some
malignant conditions;
ᑠincrease in acute phase proteins in serum, fever, increased
vascular permeability, and metabolic and pathologic changes.
ᑠThese reactions aim to prevent ongoing tissue damage, isolate
and destroy the infective organism and activate the repair
    processes necessary to restore the host/organism¶s normal
function
ᑠleukocytosis, fever, alterations in the metabolism of many
organs as well as changes in the plasma concentrations of
various acute-phase proteins made by hepatocytes in the liver
ᑠmain mediator of the acute phase reaction is IL6
ᑠregulated by IL1

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 $ Formation of a platelet plug - Vascular system and platelets
_ Activation in response to stimuli (Thromboplastin)
_ Damaged vessel releases
_ Epinephrine, collagen, thrombin, ADP, serotonin
_ Adherence to the margins of the lesion - platelets
_ Cell membrane receptors _ GpIIb/IIIa, GpIb
_ Release of granule content (caused by GpIIb/IIIa, GpIb)
_ Alpha granule _ Dense granule
_ Aggregation into a primary platelet plug

   
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á‘symptoms include nosebleeds, skin bruises, and hematomas. oral

cavity bleeding
á‘excessive menstrual bleeding, easy bruising.
á‘Prolonged bleeding after minor trauma to skin or mucous
á‘Severe hemorrhage after major surgery
 *


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á‘þeavy bleeding is common after tooth extraction or other oral
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á‘Îleeding symptoms are often exacerbated by aspirin and oral
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in the veins
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with clots in the heart because it has its effects in the veins and not
the arteries

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