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EX VIVO study
(human living skin explants)
without visible light irradiation without visible light irradiation without visible light irradiation
with visible light irradiation with visible light irradiation with visible light irradiation
Results: Nrf2
• Nrf2 content in the cell increases automatically, when the skin is exposed
to visible light Nrf2 protects skin from light-induced oxidative
stress.
• With visible light / with Ectoin®: Nrf2 content is low Ectoin® reduces
oxidative stress response of the cell. Ectoin® reduces the need of Nrf2.
without visible light irradiation without visible light irradiation without visible light irradiation
with visible light irradiation with visible light irradiation with visible light irradiation
9
Results: MC1R
UVA/visible
Results:
All tested concentrations of Ectoin©
showed highly significant photo
protection on cellular level against the
combination of UVA/visible light (68.9%
protection) and the irradiation with
Control: non-irradiated cells; Irc: untreated irradiated cells.
visible light (92.7% protection).
Source: Botta et al, 2008.
05/2017. bitop AG. 11
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05/2017. bitop AG. 12