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Drug Name Dosages Therapeutic Indications Adverse effects Contraindications Nursing considerations
Actions
clindamycin Adults Inhibits protein  Systemic  Diarrhea, Hypersensitivity. Assessment
(klin da mye' sin) synthesis in administration: nausea,  History: Allergy to
Oral susceptible Serious infections vomiting, clindamycin, history
 150–300 mg q 6 hr, bacteria, causing caused by abdominal pain; of asthma or other
clindamycin up to 300–450 mg q cell death. susceptible strains erythema allergies, allergy to
hydrochloride 6 hr in more severe of anaerobes, multiforme, tartrazine (in 75- and
Oral: infections. streptococci, contact 150-mg capsules);
Cleocin, Dalacin staphylococci, dermatitis, hepatic or renal
C (CAN) Parenteral pneumococci; exfoliative and dysfunction;
 600–2,700 mg/day in reserve use for vesiculous lactation; history of
clindamycin two to four equal penicillin-allergic dermatitis, regional enteritis or
palmitate doses; up to 4.8 patients or when urticaria; ulcerative colitis;
hydrochloride g/day IV or IM may penicillin is eosinophilia; history of antibiotic
Oral: be used for life- inappropriate; less local irritation, associated colitis
Cleocin threatening toxic antibiotics thrombophlebiti  Physical: Site of
Pediatric situations. (erythromycin) s. infection or acne;
should be  Potentially skin color, lesions;
clindamycin considered Fatal: Gasping BP; R, adventitious
Vaginal
phosphate syndrome sounds; bowel
Oral, parenteral,  One applicator (100  Parenteral: (neonates); sounds, output, liver
topical mg clindamycin Treatment of pseudomembra evaluation; CBC,
dermatologic phosphate) septicemia caused nous colitis. LFTs, renal function
solution for intravaginally, by staphylococci, tests
acne, vaginal preferably at streptococci; acute
preparation: bedtime for 7 hematogenous
consecutive days; or Interventions
Cleocin osteomyelitis;
Phosphate, insert vaginal adjunct to surgical
suppository, Systemic administration
Cleocin T, treatment of chronic  Culture infection
Cleocin Vaginal preferably at bone and joint
bedtime for 7 before therapy.
Ovules, Clinda- infections due to
consecutive days; or  Administer oral drug
Derm (CAN), susceptible
insert vaginal with a full glass of
Clindagel, organisms; do not
suppository, water or with food to
ClindaMax, use to treat
preferably at prevent esophageal
Clindets, meningitis; does not
bedtime for 3 days irritation.
Dalacin C (CAN) cross the blood–
for Cleocin Vaginal brain barrier.
Ovules.  Do not give IM
injections of more
Pregnancy  Topical
than 600 mg; inject
Category B Topical dermatologic
deep into large
 Apply a thin film to solution: Treatment
muscle to avoid
Drug class affected area bid. of acne vulgaris
serious problems.
 Lincosamide
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antibiotic Pediatric  Vaginal preparation:  Do not use for minor
Treatment of bacterial or viral
Oral bacterial vaginosis infections.
 For clindamycin HCl,
8–20 mg/kg/day in  BLACK BOX
three or four equal WARNING: Be aware
doses. For that serious to fatal
clindamycin colitis can occur;
palmitate HCl, 8–25 reserve use, and
mg/kg/day in three monitor patient
or four equal doses; closely.
for children weighing
< 10 kg, use 37.5  Monitor LFTs and
mg tid as the renal function tests,
minimum dose. and blood counts with
prolonged therapy.
Parenteral
 Neonates: 15–20 Topical dermatologic
mg/kg/day in three administration
or four equal doses.  Keep solution away
 > 1 mo: 15–40 from eyes, mouth and
mg/kg/day in three abraded skin or
or four equal doses mucous membranes;
or 350 mg/m2/day to alcohol base will
450 mg/m2/day. cause stinging. Shake
well before use.
Geriatric Patients or  Keep cool tap water
Patients with Renal available to bathe
Failure eye, mucous
 Reduce dose, and membranes, abraded
monitor patient's skin inadvertently
serum levels contacted by drug
carefully solution.

Vaginal preparation
 Give intravaginally,
preferably at bedtime.

Teaching points

Systemic administration
 Take oral drug with a
full glass of water or
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with food.
 Take full prescribed
course of oral drug.
Do not stop taking
without notifying
health care provider.

 You may experience

these side effects:
Nausea, vomiting (eat
frequent small meals);
superinfections in the
mouth, vagina (use
frequent hygiene
measures; request
treatment if severe).

 Report severe or
watery diarrhea,
abdominal pain,
inflamed mouth or
vagina, skin rash or
lesions.

Topical dermatologic
administration
 Apply thin film of acne
solution to affected
area twice daily, being
careful to avoid eyes,
mucous membranes,
abraded skin; if
solution contacts one
of these areas, flush
with lots of cool water.
 Report abdominal
pain, diarrhea.

Vaginal preparation
 Use vaginal
preparation for 7 or 3
consecutive days,
preferably at bedtime.
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Refrain from sexual
intercourse during
treatment with this
product.
 Report vaginal
irritation, itching;
diarrhea, no
improvement in
complaint being
treated.

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