Etiology

Pre Disposing Factors

8 years old Unknown
Filipino Precipitating factors
Family History Previous cancer treatment.
(+) Bronchial asthma- Exposure to radiation.
brother Mutations in
Genetic disorders.
(+) Hypertension- maternal DNA
grandmother Having a brother or sister
(+) Nasopharyngeal CA- with ALL
father, deceased
(+) Stroke- paternal
grandfather

Myeloblast
transformation

Blocks Continuous
differentiation accumulation

Immature cells

Increase amount of Abnormal cell

cells growth

“Crowd out” Cancer cells

cellular compete with
Spleen Liver Bone proliferation of normal cells
other cells

Spleenomegaly Hepatomegaly Bone pain

Erythrocytic Megakaryocitic
stem cells stem cells

Decrease Decrease
RBC platelet
Immature cells

Anemia Bleeding

Non-
functioning Fatigue
cells

Decrease
defense against
infection and
injury

Fever