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Alergen

Early Phase
Mast Cells
Bronchospas

Release histamine,
leukotrienes,
interleukins, and
prostaglandis

Infiltration of inflamatory
cells

Release cytokines,
interleukins, and other
inflammatory mediators

Airflow limitation

Late Phase
Airway inflammation Increased respons

Edema Impaired mucociliary Ephitelial injury


function

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