Rewire Your Brain. Unlearn Your Pain.

CASE STUDY: Elaina

CENTRAL PAIN OF UPPER LIMB
Post-operative pain of shoulders and arm

PAIN RELIEF WITHIN 1 WEEK – 30% REDUCTION ON VAS

30% Reduction on the visual-analogue scale (VAS)

40% INCREASE IN PAIN-FREE RANGE OF MOTION

Measured using goniometer

100% COMPLIANCE TO PROTOCOL (4 WEEKS)

Personalized plan of care according to disease related group
 Testimonials
• James R. – Chronic Low Back Pain

• “This treatment helped me push beyond the boundaries that I

have had with my pain. I would get to my level of pain and stop
and with the VR exercises I could go beyond my former pain
area. Additionally, I have more energy and able to do more, not
a great deal but more. I have been able to cut my oral pain
meds in half. Overall I found it to be a very beneficial experience
and I am very thankful.” – James R.

VR gets me motivated to move because I sit down most of

the day. This is more motivational than anything else I
tried or have done like going to the gym to exercise.
Everytime I leave these sessions I end up walking around
for awhile with less pain which normally I would just go to
my car but I feel good enough to walk around" – Jennifer
R.
 CLINICAL DEVELOPMENT
30 Person IRB-Approved Clinical Trial at Concentra and Golden Gate Sports
Medicine in San Francisco, CA
Principle Investigators: Adrian Bartoli MD and David Smolins MD

PAIN REDUCTION INCREASED ADHERENCE

Improvements in Visual Analogue Increased Compliance to plan of care

Scale (VAS)

IMPROVED FUNCTION HIGHER QUALITY OF LIFE

Oswestry and DASH Quality of life questionnaires

 Fear of Movement
62 Phase 1: Single Arm Study with 14 people at Golden Gate
Sports Therapy and Concentra Urgent Care
60
58 Measured on Fear and Avoidant Behavior Questionnaire:
(https://www.tac.vic.gov.au/files-to-move/media/upload/fear_avoidance.pdf)
56 (Baseline vs. end of 8 sessions)

54 Individuals with chronic pain experience fear of movement

52 because movement might possibly create more pain. Patients
50 who completed the program reported less fear of moving after
learning and developing strategies to minimize fear and thus
48 are able to move more and return to normal patterns of
Fear of function.

Movement
 Activities of Daily Living
46 Phase 1: Single Arm Study with 14 people at Golden Gate
Sports Therapy and Concentra Urgent Care
44
Measured ADL Questionnaire (Baseline vs. end of 8 sessions)
42
40 Pain limits an individual’s ability to perform daily activities of
living. Chronic pain patients who completed the 4 week
38 protocol reported an average decrease of 14% in ADL disability.
In other words, as fear of movement decreased, ability to
36 perform activities of daily living increased by 14%
Activities of
Daily Living
 Pain Distress
50 Phase 1: Single Arm Study with 14 people at Golden Gate
Sports Therapy and Concentra Urgent Care
40 Measured Baseline and then after 8 sessions

30 While patients who completed the program reported a 12%

reduction in the intensity of their pain, our patients reported
20 an impressive 28% decrease in how much their pain interfered
with their ability to function in their daily lives.
10 Improvements in functioning may include improvements in
general activities engagement, relationships with others, mood,
0 sleep, normal work within the home and work environments,
Pain Distress and generally better quality of life.
Academic Research Partners
Karuna Labs Inc. partners with a number of world renowned experts in
physical medicine and rehabilitation, cognitive neuroscience, pain
psychology, physical therapy, and virtual reality technology

CLINICAL
• Functional Restoration Programs, Private pay pain clinics, Biofeedback
clinics, and Physical Therapy Offices

• Dr. Laura Simons (Stanford) – Pediatric Complex Regional Pain

Syndrome
• Dr. Leigh Charvet (NYU) – Pain Efficacy with Multiple Sclerosis
• Dr. Jane Aspell (Cambridge) – Low Back Pain with Virtual
Embodiment Training
RESEARCH
• Cognitive Neuroscience research pain perception and virtual body
ownership

• Pediatric pain study on individuals with CRPS

• Clinical trial on central pain patients in functional restoration program